Kim Orth - Publications

University of Texas Southwestern, Dallas, TX, United States 

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Peng W, Casey AK, Fernandez J, Carpinone EM, Servage KA, Chen Z, Li Y, Tomchick DR, Starai VJ, Orth K. A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM. Nature Structural & Molecular Biology. PMID 32424347 DOI: 10.1038/s41594-020-0429-1  0.4
2018 Sreelatha A, Yee SS, Lopez VA, Park BC, Kinch LN, Pilch S, Servage KA, Zhang J, Jiou J, Karasiewicz-Urbańska M, Łobocka M, Grishin NV, Orth K, Kucharczyk R, Pawłowski K, et al. Protein AMPylation by an Evolutionarily Conserved Pseudokinase. Cell. PMID 30270044 DOI: 10.1016/j.cell.2018.08.046  0.4
2015 Salomon D, Klimko JA, Trudgian DC, Kinch LN, Grishin NV, Mirzaei H, Orth K. Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria. Plos Pathogens. 11: e1005128. PMID 26305100 DOI: 10.1371/journal.ppat.1005128  0.72
2015 Sreelatha A, Bennett TL, Carpinone EM, O'Brien KM, Jordan KD, Burdette DL, Orth K, Starai VJ. Vibrio effector protein VopQ inhibits fusion of V-ATPase-containing membranes. Proceedings of the National Academy of Sciences of the United States of America. 112: 100-5. PMID 25453092 DOI: 10.1073/pnas.1413764111  0.72
2014 Ham H, Woolery AR, Tracy C, Stenesen D, Krämer H, Orth K. Unfolded protein response-regulated Drosophila Fic (dFic) protein reversibly AMPylates BiP chaperone during endoplasmic reticulum homeostasis. The Journal of Biological Chemistry. 289: 36059-69. PMID 25395623 DOI: 10.1074/jbc.M114.612515  0.72
2014 Calder T, de Souza Santos M, Attah V, Klimko J, Fernandez J, Salomon D, Krachler AM, Orth K. Structural and regulatory mutations in Vibrio parahaemolyticus type III secretion systems display variable effects on virulence. Fems Microbiology Letters. 361: 107-14. PMID 25288215 DOI: 10.1111/1574-6968.12619  0.72
2014 Calder T, Kinch LN, Fernandez J, Salomon D, Grishin NV, Orth K. Vibrio type III effector VPA1380 is related to the cysteine protease domain of large bacterial toxins. Plos One. 9: e104387. PMID 25099122 DOI: 10.1371/journal.pone.0104387  0.72
2014 Yu X, Woolery AR, Luong P, Hao YH, Grammel M, Westcott N, Park J, Wang J, Bian X, Demirkan G, Hang HC, Orth K, LaBaer J. Copper-catalyzed azide-alkyne cycloaddition (click chemistry)-based detection of global pathogen-host AMPylation on self-assembled human protein microarrays. Molecular & Cellular Proteomics : McP. 13: 3164-76. PMID 25073739 DOI: 10.1074/mcp.M114.041103  0.72
2014 Salomon D, Kinch LN, Trudgian DC, Guo X, Klimko JA, Grishin NV, Mirzaei H, Orth K. Marker for type VI secretion system effectors. Proceedings of the National Academy of Sciences of the United States of America. 111: 9271-6. PMID 24927539 DOI: 10.1073/pnas.1406110111  0.72
2014 Lewallen DM, Sreelatha A, Dharmarajan V, Madoux F, Chase P, Griffin PR, Orth K, Hodder P, Thompson PR. Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation. Acs Chemical Biology. 9: 433-42. PMID 24274060 DOI: 10.1021/cb4006886  0.72
2013 Salomon D, Guo Y, Kinch LN, Grishin NV, Gardner KH, Orth K. Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides. Nature Communications. 4: 2973. PMID 24346350 DOI: 10.1038/ncomms3973  0.72
2013 Hawley CA, Watson CA, Orth K, Krachler AM. A MAM7 peptide-based inhibitor of Staphylococcus aureus adhesion does not interfere with in vitro host cell function. Plos One. 8: e81216. PMID 24265842 DOI: 10.1371/journal.pone.0081216  0.72
2013 Sreelatha A, Orth K, Starai VJ. The pore-forming bacterial effector, VopQ, halts autophagic turnover. Autophagy. 9: 2169-70. PMID 24145145 DOI: 10.4161/auto.26449  0.72
2013 Altura MA, Heath-Heckman EA, Gillette A, Kremer N, Krachler AM, Brennan C, Ruby EG, Orth K, McFall-Ngai MJ. The first engagement of partners in the Euprymna scolopes-Vibrio fischeri symbiosis is a two-step process initiated by a few environmental symbiont cells. Environmental Microbiology. 15: 2937-50. PMID 23819708 DOI: 10.1111/1462-2920.12179  0.72
2013 Krachler AM, Orth K. Targeting the bacteria-host interface: strategies in anti-adhesion therapy. Virulence. 4: 284-94. PMID 23799663 DOI: 10.4161/viru.24606  0.72
2013 Sreelatha A, Bennett TL, Zheng H, Jiang QX, Orth K, Starai VJ. Vibrio effector protein, VopQ, forms a lysosomal gated channel that disrupts host ion homeostasis and autophagic flux. Proceedings of the National Academy of Sciences of the United States of America. 110: 11559-64. PMID 23798441 DOI: 10.1073/pnas.1307032110  0.72
2012 Ham H, Orth K. The role of type III secretion System 2 in Vibrio parahaemolyticus pathogenicity Journal of Microbiology. 50: 719-725. PMID 23124738 DOI: 10.1007/s12275-012-2550-2  0.72
2012 Zhang L, Krachler AM, Broberg CA, Li Y, Mirzaei H, Gilpin CJ, Orth K. Type III effector VopC mediates invasion for Vibrio species. Cell Reports. 1: 453-60. PMID 22787576 DOI: 10.1016/j.celrep.2012.04.004  0.72
2012 Krachler AM, Mende K, Murray C, Orth K. In vitro characterization of multivalent adhesion molecule 7-based inhibition of multidrug-resistant bacteria isolated from wounded military personnel. Virulence. 3: 389-99. PMID 22722243 DOI: 10.4161/viru.20816  0.72
2012 Krachler AM, Ham H, Orth K. Turnabout is fair play: use of the bacterial Multivalent Adhesion Molecule 7 as an antimicrobial agent. Virulence. 3: 68-71. PMID 22086133 DOI: 10.4161/viru.3.1.18172  0.72
2011 Krachler AM, Woolery AR, Orth K. Manipulation of kinase signaling by bacterial pathogens. The Journal of Cell Biology. 195: 1083-92. PMID 22123833 DOI: 10.1083/jcb.201107132  0.72
2011 Ham H, Orth K. De-AMPylation unmasked: Modulation of host membrane trafficking Science Signaling. 4. PMID 21990428 DOI: 10.1126/scisignal.2002458  0.72
2011 Krachler AM, Orth K. Functional characterization of the interaction between bacterial adhesin multivalent adhesion molecule 7 (MAM7) protein and its host cell ligands. The Journal of Biological Chemistry. 286: 38939-47. PMID 21937438 DOI: 10.1074/jbc.M111.291377  0.72
2011 Ham H, Sreelatha A, Orth K. Manipulation of host membranes by bacterial effectors Nature Reviews Microbiology. 9: 635-646. PMID 21765451 DOI: 10.1038/nrmicro2602  0.72
2011 Krachler AM, Ham H, Orth K. Outer membrane adhesion factor multivalent adhesion molecule 7 initiates host cell binding during infection by gram-negative pathogens. Proceedings of the National Academy of Sciences of the United States of America. 108: 11614-9. PMID 21709226 DOI: 10.1073/pnas.1102360108  0.72
2011 Li Y, Al-Eryani R, Yarbrough ML, Orth K, Ball HL. Characterization of AMPylation on threonine, serine, and tyrosine using mass spectrometry. Journal of the American Society For Mass Spectrometry. 22: 752-61. PMID 21472612 DOI: 10.1007/s13361-011-0084-1  0.72
2011 Hao YH, Chuang T, Ball HL, Luong P, Li Y, Flores-Saaib RD, Orth K. Characterization of a rabbit polyclonal antibody against threonine-AMPylation. Journal of Biotechnology. 151: 251-4. PMID 21185336 DOI: 10.1016/j.jbiotec.2010.12.013  0.72
2010 Luong P, Kinch LN, Brautigam CA, Grishin NV, Tomchick DR, Orth K. Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain. The Journal of Biological Chemistry. 285: 20155-63. PMID 20410310 DOI: 10.1074/jbc.M110.114884  0.72
2009 Burdette DL, Seemann J, Orth K. Vibrio VopQ induces PI3-kinase-independent autophagy and antagonizes phagocytosis. Molecular Microbiology. 73: 639-49. PMID 19627496 DOI: 10.1111/j.1365-2958.2009.06798.x  0.4
2009 Kinch LN, Yarbrough ML, Orth K, Grishin NV. Fido, a novel AMPylation domain common to fic, doc, and AvrB. Plos One. 4: e5818. PMID 19503829 DOI: 10.1371/journal.pone.0005818  0.72
2009 Yarbrough ML, Orth K. AMPylation is a new post-translational modiFICation. Nature Chemical Biology. 5: 378-9. PMID 19448605 DOI: 10.1038/nchembio0609-378  0.36
2009 Yarbrough ML, Li Y, Kinch LN, Grishin NV, Ball HL, Orth K. AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. Science (New York, N.Y.). 323: 269-72. PMID 19039103 DOI: 10.1126/science.1166382  0.72
2009 Burdette DL, Yarbrough ML, Orth K. Not without cause: Vibrio parahaemolyticus induces acute autophagy and cell death. Autophagy. 5: 100-2. PMID 19011375  0.4
2008 Burdette DL, Yarbrough ML, Orvedahl A, Gilpin CJ, Orth K. Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis. Proceedings of the National Academy of Sciences of the United States of America. 105: 12497-502. PMID 18713860 DOI: 10.1073/pnas.0802773105  0.4
2008 Hao YH, Wang Y, Burdette D, Mukherjee S, Keitany G, Goldsmith E, Orth K. Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways. Plos One. 3: e1375. PMID 18167536 DOI: 10.1371/journal.pone.0001375  0.4
2008 Trosky JE, Liverman AD, Orth K. Yersinia outer proteins: Yops. Cellular Microbiology. 10: 557-65. PMID 18081726 DOI: 10.1111/j.1462-5822.2007.01109.x  0.36
2007 Liverman ADB, Cheng HC, Trosky JE, Leung DW, Yarbrough ML, Burdette DL, Rosen MK, Orth K. Arp2/3-independent assembly of actin by Vibrio type III effector VopL Proceedings of the National Academy of Sciences of the United States of America. 104: 17117-17122. PMID 17942696 DOI: 10.1073/pnas.0703196104  0.72
2007 Trosky JE, Li Y, Mukherjee S, Keitany G, Ball H, Orth K. VopA inhibits ATP binding by acetylating the catalytic loop of MAPK kinases. The Journal of Biological Chemistry. 282: 34299-305. PMID 17881352 DOI: 10.1074/jbc.M706970200  0.36
2006 Mukherjee S, Keitany G, Li Y, Wang Y, Ball HL, Goldsmith EJ, Orth K. Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science (New York, N.Y.). 312: 1211-4. PMID 16728640 DOI: 10.1126/science.1126867  0.72
2004 Trosky JE, Mukherjee S, Burdette DL, Roberts M, McCarter L, Siegel RM, Orth K. Inhibition of MAPK signaling pathways by VopA from Vibrio parahaemolyticus. The Journal of Biological Chemistry. 279: 51953-7. PMID 15459200 DOI: 10.1074/jbc.M407001200  0.72
2003 Hotson A, Chosed R, Shu H, Orth K, Mudgett MB. Xanthomonas type III effector XopD targets SUMO-conjugated proteins in planta. Molecular Microbiology. 50: 377-89. PMID 14617166 DOI: 10.1046/j.1365-2958.2003.03730.x  0.72
2002 Collier-Hyams LS, Zeng H, Sun J, Tomlinson AD, Bao ZQ, Chen H, Madara JL, Orth K, Neish AS. Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway. Journal of Immunology (Baltimore, Md. : 1950). 169: 2846-50. PMID 12218096 DOI: 10.4049/jimmunol.169.6.2846  0.72
2002 Orth K, Dixon JE, Bliska JB. 20 Effector proteins of bacterial type III protein secretion systems: Elucidating their biochemical effects on eukaryotic signaling cascades Methods in Microbiology. 31: 361-376.  0.72
2000 Juris SJ, Rudolph AE, Huddler D, Orth K, Dixon JE. A distinctive role for the Yersinia protein kinase: actin binding, kinase activation, and cytoskeleton disruption. Proceedings of the National Academy of Sciences of the United States of America. 97: 9431-6. PMID 10920208 DOI: 10.1073/PNAS.170281997  0.44
1994 Orth K, Hung J, Gazdar A, Bowcock A, Mathis JM, Sambrook J. Genetic instability in human ovarian cancer cell lines. Proceedings of the National Academy of Sciences of the United States of America. 91: 9495-9. PMID 7937795 DOI: 10.1073/pnas.91.20.9495  0.72
1994 Orth K, Hung J, Gazdar A, Mathis M, Bowcock A, Sambrook J. Ovarian tumors display persistent microsatellite instability caused by mutation in the mismatch repair gene hMSH-2 Cold Spring Harbor Symposia On Quantitative Biology. 59: 349-356. PMID 7587087 DOI: 10.1101/SQB.1994.059.01.039  0.72
1992 Orth K, Madison EL, Gething MJ, Sambrook JF, Herz J. Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 89: 7422-6. PMID 1502153 DOI: 10.1073/pnas.89.16.7422  0.72
1991 Letsou A, Alexander S, Orth K, Wasserman SA. Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity. Proceedings of the National Academy of Sciences of the United States of America. 88: 810-4. PMID 1899484 DOI: 10.1073/PNAS.88.3.810  0.72
1989 Hus PL, Chamberlain NR, Orth K, Moomaw CR, Zhang LQ, Slaughter CA, Radolf JD, Sell S, Norgard MV. Sequence analysis of the 47-kilodalton major integral membrane immunogen of Treponema pallidum Infection and Immunity. 57: 196-203. PMID 2642466  0.72
1989 Hansen EJ, Pelzel SE, Orth K, Moomaw CR, Radolf JD, Slaughter CA. Structural and antigenic conservation of the P2 porin protein among strains of Haemophilus influenzae type b Infection and Immunity. 57: 3270-3275. PMID 2478470  0.72
1986 Peterson CL, Orth K, Calame KL. Binding in vitro of multiple cellular proteins to immunoglobulin heavy-chain enhancer DNA. Molecular and Cellular Biology. 6: 4168-78. PMID 3025641  0.72
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