Melanie Ott - Publications

Affiliations: 
Gladstone Institute of Virology J. David Gladstone Institutes 
Website:
https://gladstone.org/people/melanie-ott

71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Lyons DE, McMahon S, Ott M. A combinatorial view of old and new RNA polymerase II modifications. Transcription. 1-17. PMID 32401151 DOI: 10.1080/21541264.2020.1762468  0.01
2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, ... ... Ott M, et al. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. PMID 32353859 DOI: 10.1038/S41586-020-2286-9  0.01
2019 Khan S, Lew I, Wu F, Fritts L, Fontaine KA, Tomar S, Trapecar M, Shehata HM, Ott M, Miller CJ, Sanjabi S. Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract. Nature Communications. 10: 4344. PMID 31554802 DOI: 10.1038/S41467-019-12371-7  0.01
2019 Schilling B, Meyer JG, Wei L, Ott M, Verdin E. High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets. Methods in Molecular Biology (Clifton, N.J.). 1983: 3-16. PMID 31087289 DOI: 10.1007/978-1-4939-9434-2_1  0.01
2019 Ali I, Ruiz DG, Ni Z, Johnson JR, Zhang H, Li PC, Khalid MM, Conrad RJ, Guo X, Min J, Greenblatt J, Jacobson M, Krogan NJ, Ott M. Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins. Molecular Cell. PMID 31054975 DOI: 10.1016/J.Molcel.2019.04.008  0.01
2018 Tomar S, Ali I, Ott M. A BAF'ling Approach to Curing HIV. Cell Chemical Biology. 25: 1441-1442. PMID 30576660 DOI: 10.1016/J.Chembiol.2018.12.007  0.01
2018 Fontaine KA, Leon KE, Khalid MM, Tomar S, Jimenez-Morales D, Dunlap M, Kaye JA, Shah PS, Finkbeiner S, Krogan NJ, Ott M. The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein. Mbio. 9. PMID 30401782 DOI: 10.1128/Mbio.02126-18  0.01
2018 Ali I, Conrad RJ, Verdin E, Ott M. Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics. Chemical Reviews. PMID 29405707 DOI: 10.1021/Acs.Chemrev.7B00181  0.01
2017 Jeng MY, Hull PA, Fei M, Kwon HS, Tsou CL, Kasler H, Ng CP, Gordon DE, Johnson J, Krogan N, Verdin E, Ott M. Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. The Journal of Experimental Medicine. PMID 29191913 DOI: 10.1084/Jem.20161066  0.01
2017 Boehm D, Ott M. Host Methyltransferases and Demethylases: Potential New Epigenetic Targets for HIV Cure Strategies and Beyond. Aids Research and Human Retroviruses. 33: S8-S22. PMID 29140109 DOI: 10.1089/Aid.2017.0180  0.01
2017 Boehm D, Ott M. Flow Cytometric Analysis of HIV-1 Transcriptional Activity in Response to shRNA Knockdown in A2 and A72 J-Lat Cell Lines. Bio-Protocol. 7. PMID 29082287 DOI: 10.21769/BioProtoc.2314  0.01
2017 Conrad RJ, Fozouni P, Thomas S, Sy H, Zhang Q, Zhou MM, Ott M. The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes. Molecular Cell. PMID 28844864 DOI: 10.1016/J.Molcel.2017.07.025  0.01
2017 Boehm D, Ott M. Flow Cytometric Analysis of Drug-induced HIV-1 Transcriptional Activity in A2 and A72 J-Lat Cell Lines. Bio-Protocol. 7. PMID 28835903 DOI: 10.21769/BioProtoc.2290  0.01
2017 Boehm D, Jeng M, Camus G, Gramatica A, Schwarzer R, Johnson JR, Hull PA, Montano M, Sakane N, Pagans S, Godin R, Deeks SG, Krogan NJ, Greene WC, Ott M. SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency. Cell Host & Microbe. 21: 569-579.e6. PMID 28494238 DOI: 10.1016/J.Chom.2017.04.011  0.01
2016 Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, et al. The mTOR Complex Controls HIV Latency. Cell Host & Microbe. 20: 785-797. PMID 27978436 DOI: 10.1016/J.Chom.2016.11.001  0.01
2016 Ali I, Conrad RJ, Ott M. Retrovirus Integration: Some Assembly Required? Cell Host & Microbe. 20: 702-704. PMID 27978432 DOI: 10.1016/J.Chom.2016.11.003  0.01
2016 Khan S, Woodruff EM, Trapecar M, Fontaine KA, Ezaki A, Borbet TC, Ott M, Sanjabi S. Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication. The Journal of Experimental Medicine. PMID 27852793 DOI: 10.1084/Jem.20161289  0.01
2016 Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, ... ... Ott M, et al. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nature Medicine. PMID 27400264 DOI: 10.1038/Nm.4108  0.01
2016 Shirakawa K, Wang L, Man N, Maksimoska J, Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E. Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife. 5. PMID 27244239 DOI: 10.7554/Elife.11156  0.01
2016 Meyers NL, Fontaine KA, Kumar GR, Ott M. Entangled in a membranous web: ER and lipid droplet reorganization during hepatitis C virus infection. Current Opinion in Cell Biology. 41: 117-124. PMID 27240021 DOI: 10.1016/J.Ceb.2016.05.003  0.01
2016 Ali I, Ramage H, Boehm D, Dirk LM, Sakane N, Hanada K, Pagans S, Kaehlcke K, Aul K, Weinberger L, Trievel R, Schnoelzer M, Kamada M, Houtz R, Ott M. The HIV-1 Tat protein is monomethylated at lysine-71 by the lysine methyltransferase KMT7. The Journal of Biological Chemistry. PMID 27235396 DOI: 10.1074/Jbc.M116.735415  0.01
2016 Conrad RJ, Ott M. Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses. Acs Chemical Biology. PMID 26845514 DOI: 10.1021/Acschembio.5B00999  0.01
2015 Vogt DA, Ott M. Membrane Flotation Assay. Bio-Protocol. 5. PMID 27540564  0.01
2015 Rosenkranz E, Metz CH, Maywald M, Hilgers RD, Weßels I, Senff T, Haase H, Jäger M, Ott M, Aspinall R, Plümäkers B, Rink L. Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures. Molecular Nutrition & Food Research. PMID 26614004 DOI: 10.1002/Mnfr.201500524  0.01
2015 Jeng MY, Ali I, Ott M. Manipulation of the host protein acetylation network by human immunodeficiency virus type 1. Critical Reviews in Biochemistry and Molecular Biology. 50: 314-25. PMID 26329395 DOI: 10.3109/10409238.2015.1061973  0.01
2015 Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, ... ... Ott M, et al. SIRT1 deacetylates RORγt and enhances Th17 cell generation. The Journal of Experimental Medicine. 212: 973. PMID 25987725 DOI: 10.1084/jem.2013237805062015c  0.01
2015 Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, ... ... Ott M, et al. SIRT1 deacetylates RORγt and enhances Th17 cell generation. The Journal of Experimental Medicine. 212: 607-17. PMID 25918343 DOI: 10.1084/Jem.20132378  0.01
2015 Simonti CN, Pollard KS, Schröder S, He D, Bruneau BG, Ott M, Capra JA. Evolution of lysine acetylation in the RNA polymerase II C-terminal domain. Bmc Evolutionary Biology. 15: 35. PMID 25887984 DOI: 10.1186/S12862-015-0327-Z  0.01
2015 Ramage HR, Kumar GR, Verschueren E, Johnson JR, Von Dollen J, Johnson T, Newton B, Shah P, Horner J, Krogan NJ, Ott M. A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay. Molecular Cell. 57: 329-40. PMID 25616068 DOI: 10.1016/J.Molcel.2014.12.028  0.01
2015 Verdin E, Ott M. 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond. Nature Reviews. Molecular Cell Biology. 16: 258-64. PMID 25549891 DOI: 10.1038/Nrm3931  0.01
2014 Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M. The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets. The Journal of Biological Chemistry. 289: 35770-80. PMID 25381252 DOI: 10.1074/Jbc.M114.587816  0.01
2013 Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, ... Ott M, et al. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Molecular Cell. 52: 314-24. PMID 24207025 DOI: 10.1016/J.Molcel.2013.10.009  0.01
2013 Camus G, Vogt DA, Kondratowicz AS, Ott M. Lipid droplets and viral infections. Methods in Cell Biology. 116: 167-90. PMID 24099293 DOI: 10.1016/B978-0-12-408051-5.00009-7  0.01
2013 Webster B, Ott M, Greene WC. Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus. Journal of Virology. 87: 13354-69. PMID 24089557 DOI: 10.1128/Jvi.02465-13  0.01
2013 Verdin E, Ott M. Acetylphosphate: a novel link between lysine acetylation and intermediary metabolism in bacteria. Molecular Cell. 51: 132-4. PMID 23870140 DOI: 10.1016/J.Molcel.2013.07.006  0.01
2013 Boehm D, Conrad RJ, Ott M. Bromodomain proteins in HIV infection. Viruses. 5: 1571-86. PMID 23793227 DOI: 10.3390/V5061571  0.01
2013 Ott M, Verdin E. Three rules for HIV latency: location, location, and location. Cell Host & Microbe. 13: 625-6. PMID 23768485 DOI: 10.1016/J.Chom.2013.05.016  0.01
2013 Camus G, Ott M. How the antiviral immune response boosts liver fat. Nature Medicine. 19: 671-2. PMID 23744144 DOI: 10.1038/Nm.3226  0.01
2013 Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M. Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. Plos Pathogens. 9: e1003302. PMID 23593007 DOI: 10.1371/Journal.Ppat.1003302  0.01
2013 Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Ott M. Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. The Journal of Biological Chemistry. 288: 9915-23. PMID 23420847 DOI: 10.1074/Jbc.M112.434910  0.01
2013 Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li PC, Planelles V, Bradner JE, Zhou MM, Siliciano RF, Weinberger L, Verdin E, Ott M. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle (Georgetown, Tex.). 12: 452-62. PMID 23255218 DOI: 10.4161/Cc.23309  0.01
2013 Webster B, Wissing S, Herker E, Ott M, Greene WC. Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis. Journal of Virology. 87: 581-96. PMID 23097449 DOI: 10.1128/Jvi.01047-12  0.01
2012 Kwon HS, Lim HW, Wu J, Schnölzer M, Verdin E, Ott M. Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 188: 2712-21. PMID 22312127 DOI: 10.4049/Jimmunol.1100903  0.01
2012 Herker E, Ott M. Emerging role of lipid droplets in host/pathogen interactions. The Journal of Biological Chemistry. 287: 2280-7. PMID 22090026 DOI: 10.1074/Jbc.R111.300202  0.01
2012 Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M. Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. The Journal of Biological Chemistry. 287: 1090-9. PMID 22084242 DOI: 10.1074/Jbc.M111.282855  0.01
2011 Ott M, Geyer M, Zhou Q. The control of HIV transcription: keeping RNA polymerase II on track. Cell Host & Microbe. 10: 426-35. PMID 22100159 DOI: 10.1016/J.Chom.2011.11.002  0.01
2011 Harris C, Herker E, Farese RV, Ott M. Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis. The Journal of Biological Chemistry. 286: 42615-25. PMID 21984835 DOI: 10.1074/Jbc.M111.285148  0.01
2011 Sakane N, Kwon HS, Pagans S, Kaehlcke K, Mizusawa Y, Kamada M, Lassen KG, Chan J, Greene WC, Schnoelzer M, Ott M. Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). Plos Pathogens. 7: e1002184. PMID 21876670 DOI: 10.1371/Journal.Ppat.1002184  0.01
2011 Herker E, Ott M. Unique ties between hepatitis C virus replication and intracellular lipids. Trends in Endocrinology and Metabolism: Tem. 22: 241-8. PMID 21497514 DOI: 10.1016/J.Tem.2011.03.004  0.01
2011 Pagans S, Sakane N, Schnölzer M, Ott M. Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies. Methods (San Diego, Calif.). 53: 91-6. PMID 20615470 DOI: 10.1016/J.Ymeth.2010.07.001  0.01
2010 Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV, Ott M. Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nature Medicine. 16: 1295-8. PMID 20935628 DOI: 10.1038/Nm.2238  0.01
2010 Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 67: 953-66. PMID 20869593 DOI: 10.1016/J.Neuron.2010.08.044  0.01
2010 Ott M, Verdin E. HAT trick: p300, small molecule, inhibitor. Chemistry & Biology. 17: 417-8. PMID 20534339 DOI: 10.1016/J.Chembiol.2010.05.002  0.01
2010 Cho S, Schroeder S, Ott M. CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation. Cell Cycle (Georgetown, Tex.). 9: 1697-705. PMID 20436276 DOI: 10.4161/Cc.9.9.11346  0.01
2010 Pagans S, Kauder SE, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel RC, Verdin E, Schnolzer M, Ott M. The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host & Microbe. 7: 234-44. PMID 20227666 DOI: 10.1016/J.Chom.2010.02.005  0.01
2009 Cho S, Schroeder S, Kaehlcke K, Kwon HS, Pedal A, Herker E, Schnoelzer M, Ott M. Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells. The Embo Journal. 28: 1407-17. PMID 19387490 DOI: 10.1038/Emboj.2009.99  0.01
2008 Kwon HS, Ott M. The ups and downs of SIRT1. Trends in Biochemical Sciences. 33: 517-25. PMID 18805010 DOI: 10.1016/J.Tibs.2008.08.001  0.01
2008 Kwon HS, Brent MM, Getachew R, Jayakumar P, Chen LF, Schnolzer M, McBurney MW, Marmorstein R, Greene WC, Ott M. Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host & Microbe. 3: 158-67. PMID 18329615 DOI: 10.1016/J.Chom.2008.02.002  0.01
2006 Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M, Verdin E. The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. The Journal of Biological Chemistry. 281: 19960-8. PMID 16687403 DOI: 10.1074/Jbc.M603336200  0.01
2005 Pagans S, Pedal A, North BJ, Kaehlcke K, Marshall BL, Dorr A, Hetzer-Egger C, Henklein P, Frye R, McBurney MW, Hruby H, Jung M, Verdin E, Ott M. SIRT1 regulates HIV transcription via Tat deacetylation. Plos Biology. 3: e41. PMID 15719057 DOI: 10.1371/Journal.Pbio.0030041  0.01
2004 Ott M, Dorr A, Hetzer-Egger C, Kaehlcke K, Schnolzer M, Henklein P, Cole P, Zhou MM, Verdin E. Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation. Novartis Foundation Symposium. 259: 182-93; discussion 1. PMID 15171254 DOI: 10.1002/0470862637.Ch13  0.01
2003 Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V, Henklein P, Schnoelzer M, Loret E, Cole PA, Verdin E, Ott M. Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Molecular Cell. 12: 167-76. PMID 12887902 DOI: 10.1016/S1097-2765(03)00245-4  0.01
2002 Schwer B, North BJ, Frye RA, Ott M, Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. The Journal of Cell Biology. 158: 647-57. PMID 12186850 DOI: 10.1083/Jcb.200205057  0.01
2002 Dorr A, Kiermer V, Pedal A, Rackwitz HR, Henklein P, Schubert U, Zhou MM, Verdin E, Ott M. Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. The Embo Journal. 21: 2715-23. PMID 12032084 DOI: 10.1093/Emboj/21.11.2715  0.01
2002 Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, Ott M, Verdin E, Zhou MM. Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Molecular Cell. 9: 575-86. PMID 11931765 DOI: 10.1016/S1097-2765(02)00483-5  0.01
1998 Ott M, Lovett JL, Mueller L, Verdin E. Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-kappaB factors. Journal of Immunology (Baltimore, Md. : 1950). 160: 2872-80. PMID 9510190  0.01
1998 Emiliani S, Fischle W, Ott M, Van Lint C, Amella CA, Verdin E. Mutations in the tat gene are responsible for human immunodeficiency virus type 1 postintegration latency in the U1 cell line. Journal of Virology. 72: 1666-70. PMID 9445075 DOI: 10.1128/Jvi.72.2.1666-1670.1998  0.01
1997 Ott M, Emiliani S, Van Lint C, Herbein G, Lovett J, Chirmule N, McCloskey T, Pahwa S, Verdin E. Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway. Science (New York, N.Y.). 275: 1481-5. PMID 9045614 DOI: 10.1126/Science.275.5305.1481  0.01
1997 McCloskey TW, Ott M, Tribble E, Khan SA, Teichberg S, Paul MO, Pahwa S, Verdin E, Chirmule N. Dual Role of HIV Tat in Regulation of Apoptosis in T Cells Journal of Immunology. 158: 1014-1019. PMID 8993024  0.01
1996 Emiliani S, Van Lint C, Fischle W, Paras P, Ott M, Brady J, Verdin E. A point mutation in the HIV-1 Tat responsive element is associated with postintegration latency. Proceedings of the National Academy of Sciences of the United States of America. 93: 6377-81. PMID 8692823 DOI: 10.1073/Pnas.93.13.6377  0.01
1996 Van Lint C, Emiliani S, Ott M, Verdin E. Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. The Embo Journal. 15: 1112-20. PMID 8605881  0.01
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