Alan Sher - Publications

Affiliations: 
LPD NIAID, NIH, Rockville, MD, United States 

174 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Rockwood N, Costa DL, Amaral EP, Du Bruyn E, Kubler A, Gil-Santana L, Fukutani KF, Scanga CA, Flynn JL, Jackson SH, Wilkinson KA, Bishai WR, Sher A, Wilkinson RJ, Andrade BB. Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes. Frontiers in Immunology. 8: 542. PMID 28553288 DOI: 10.3389/Fimmu.2017.00542  0.36
2016 Arbore G, West EE, Spolski R, Robertson AA, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, et al. T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells. Science (New York, N.Y.). 352: aad1210. PMID 27313051 DOI: 10.1126/Science.Aad1210  0.36
2015 Andrade BB, Pavan Kumar N, Amaral EP, Riteau N, Mayer-Barber KD, Tosh KW, Maier N, Conceição EL, Kubler A, Sridhar R, Banurekha VV, Jawahar MS, Barbosa T, Manganiello VC, Moss J, ... ... Sher A, et al. Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 195: 2763-73. PMID 26268658 DOI: 10.4049/Jimmunol.1500942  0.36
2015 Tassi I, Claudio E, Wang H, Tang W, Ha HL, Saret S, Sher A, Jankovic D, Siebenlist U. Adaptive immune-mediated host resistance to Toxoplasma gondii is governed by the NF-κB regulator Bcl-3 in dendritic cells. European Journal of Immunology. 45: 1972-9. PMID 25884683 DOI: 10.1002/Eji.201445045  0.36
2015 Mayer-Barber KD, Sher A. Cytokine and lipid mediator networks in tuberculosis. Immunological Reviews. 264: 264-75. PMID 25703565 DOI: 10.1111/Imr.12249  0.36
2014 Cardone M, Dzutsev AK, Li H, Riteau N, Gerosa F, Shenderov K, Winkler-Pickett R, Provezza L, Riboldi E, Leighty RM, Orr SJ, Steinhagen F, Wewers MD, Sher A, Anderson SK, et al. Interleukin-1 and interferon-γ orchestrate β-glucan-activated human dendritic cell programming via IκB-ζ modulation. Plos One. 9: e114516. PMID 25474109 DOI: 10.1371/Journal.Pone.0114516  0.36
2014 Andrade BB, Singh A, Narendran G, Schechter ME, Nayak K, Subramanian S, Anbalagan S, Jensen SM, Porter BO, Antonelli LR, Wilkinson KA, Wilkinson RJ, Meintjes G, van der Plas H, Follmann D, ... ... Sher A, et al. Mycobacterial antigen driven activation of CD14++CD16- monocytes is a predictor of tuberculosis-associated immune reconstitution inflammatory syndrome. Plos Pathogens. 10: e1004433. PMID 25275318 DOI: 10.1371/Journal.Ppat.1004433  0.36
2014 Mayer-Barber KD, Andrade BB, Oland SD, Amaral EP, Barber DL, Gonzales J, Derrick SC, Shi R, Kumar NP, Wei W, Yuan X, Zhang G, Cai Y, Babu S, Catalfamo M, ... ... Sher A, et al. Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk. Nature. 511: 99-103. PMID 24990750 DOI: 10.1038/Nature13489  0.36
2014 Escobar TM, Kanellopoulou C, Kugler DG, Kilaru G, Nguyen CK, Nagarajan V, Bhairavabhotla RK, Northrup D, Zahr R, Burr P, Liu X, Zhao K, Sher A, Jankovic D, Zhu J, et al. miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression. Immunity. 40: 865-79. PMID 24856900 DOI: 10.1016/J.Immuni.2014.03.014  0.36
2014 Gorfu G, Cirelli KM, Melo MB, Mayer-Barber K, Crown D, Koller BH, Masters S, Sher A, Leppla SH, Moayeri M, Saeij JP, Grigg ME. Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii. Mbio. 5. PMID 24549849 DOI: 10.1128/Mbio.01117-13  0.36
2014 Gazzinelli RT, Mendonça-Neto R, Lilue J, Howard J, Sher A. Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men. Cell Host & Microbe. 15: 132-8. PMID 24528860 DOI: 10.1016/J.Chom.2014.01.004  0.36
2014 Shenderov K, Riteau N, Yip R, Mayer-Barber KD, Oland S, Hieny S, Fitzgerald P, Oberst A, Dillon CP, Green DR, Cerundolo V, Sher A. Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway. Journal of Immunology (Baltimore, Md. : 1950). 192: 2029-33. PMID 24489101 DOI: 10.4049/Jimmunol.1302549  0.36
2014 Andrade BB, Pavan Kumar N, Sridhar R, Banurekha VV, Jawahar MS, Nutman TB, Sher A, Babu S. Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity. Chest. 145: 1244-54. PMID 24458266 DOI: 10.1378/Chest.13-1799  0.36
2014 Barber DL, Andrade BB, McBerry C, Sereti I, Sher A. Role of IL-6 in Mycobacterium avium--associated immune reconstitution inflammatory syndrome. Journal of Immunology (Baltimore, Md. : 1950). 192: 676-82. PMID 24337386 DOI: 10.4049/Jimmunol.1301004  0.36
2014 Redford PS, Mayer-Barber KD, McNab FW, Stavropoulos E, Wack A, Sher A, O'Garra A. Influenza A virus impairs control of Mycobacterium tuberculosis coinfection through a type I interferon receptor-dependent pathway. The Journal of Infectious Diseases. 209: 270-4. PMID 23935205 DOI: 10.1093/Infdis/Jit424  0.36
2013 Kugler DG, Mittelstadt PR, Ashwell JD, Sher A, Jankovic D. CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection. The Journal of Experimental Medicine. 210: 1919-27. PMID 23980098 DOI: 10.1084/Jem.20122300  0.36
2013 Narendran G, Andrade BB, Porter BO, Chandrasekhar C, Venkatesan P, Menon PA, Subramanian S, Anbalagan S, Bhavani KP, Sekar S, Padmapriyadarshini C, Kumar S, Ravichandran N, Raja K, Bhanu K, ... ... Sher A, et al. Paradoxical tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS) in HIV patients with culture confirmed pulmonary tuberculosis in India and the potential role of IL-6 in prediction. Plos One. 8: e63541. PMID 23691062 DOI: 10.1371/Journal.Pone.0063541  0.36
2013 Andrade BB, Pavan Kumar N, Mayer-Barber KD, Barber DL, Sridhar R, Rekha VV, Jawahar MS, Nutman TB, Sher A, Babu S. Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease. Plos One. 8: e62618. PMID 23671613 DOI: 10.1371/Journal.Pone.0062618  0.36
2013 Shenderov K, Barber DL, Mayer-Barber KD, Gurcha SS, Jankovic D, Feng CG, Oland S, Hieny S, Caspar P, Yamasaki S, Lin X, Ting JP, Trinchieri G, Besra GS, Cerundolo V, ... Sher A, et al. Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome. Journal of Immunology (Baltimore, Md. : 1950). 190: 5722-30. PMID 23630357 DOI: 10.4049/Jimmunol.1203343  0.36
2013 Mackey-Lawrence NM, Guo X, Sturdevant DE, Virtaneva K, Hernandez MM, Houpt E, Sher A, Porcella SF, Petri WA. Effect of the leptin receptor Q223R polymorphism on the host transcriptome following infection with Entamoeba histolytica. Infection and Immunity. 81: 1460-70. PMID 23429533 DOI: 10.1128/Iai.00689-13  0.36
2013 Andrade BB, Hullsiek KH, Boulware DR, Rupert A, French MA, Ruxrungtham K, Montes ML, Price H, Barreiro P, Audsley J, Sher A, Lewin SR, Sereti I. Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses. The Journal of Infectious Diseases. 207: 1379-88. PMID 23335804 DOI: 10.1093/Infdis/Jit033  0.36
2013 Koblansky AA, Jankovic D, Oh H, Hieny S, Sungnak W, Mathur R, Hayden MS, Akira S, Sher A, Ghosh S. Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. Immunity. 38: 119-30. PMID 23246311 DOI: 10.1016/J.Immuni.2012.09.016  0.36
2012 Wasmuth JD, Pszenny V, Haile S, Jansen EM, Gast AT, Sher A, Boyle JP, Boulanger MJ, Parkinson J, Grigg ME. Integrated bioinformatic and targeted deletion analyses of the SRS gene superfamily identify SRS29C as a negative regulator of Toxoplasma virulence. Mbio. 3. PMID 23149485 DOI: 10.1128/Mbio.00321-12  0.36
2012 Rothfuchs AG, Roffê E, Gibson A, Cheever AW, Ezekowitz RA, Takahashi K, Steindel M, Sher A, Báfica A. Mannose-binding lectin regulates host resistance and pathology during experimental infection with Trypanosoma cruzi. Plos One. 7: e47835. PMID 23139754 DOI: 10.1371/Journal.Pone.0047835  0.36
2012 Abdalla H, Srinivasan L, Shah S, Mayer-Barber KD, Sher A, Sutterwala FS, Briken V. Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1β and IL-18 secretion but not to pyroptosis. Plos One. 7: e40722. PMID 22911706 DOI: 10.1371/Journal.Pone.0040722  0.36
2012 Pearce EJ, Caspar P, Grzych JM, Lewis FA, Sher A. Pillars article: downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp. Med. 1991. 173: 159-166. Journal of Immunology (Baltimore, Md. : 1950). 189: 1104-11. PMID 22815380  0.36
2012 Goldszmid RS, Caspar P, Rivollier A, White S, Dzutsev A, Hieny S, Kelsall B, Trinchieri G, Sher A. NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection. Immunity. 36: 1047-59. PMID 22749354 DOI: 10.1016/J.Immuni.2012.03.026  0.36
2012 Shi CS, Shenderov K, Huang NN, Kabat J, Abu-Asab M, Fitzgerald KA, Sher A, Kehrl JH. Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction. Nature Immunology. 13: 255-63. PMID 22286270 DOI: 10.1038/Ni.2215  0.36
2012 Barber DL, Andrade BB, Sereti I, Sher A. Immune reconstitution inflammatory syndrome: the trouble with immunity when you had none. Nature Reviews. Microbiology. 10: 150-6. PMID 22230950 DOI: 10.1038/Nrmicro2712  0.36
2012 Mahnke YD, Greenwald JH, DerSimonian R, Roby G, Antonelli LR, Sher A, Roederer M, Sereti I. Selective expansion of polyfunctional pathogen-specific CD4(+) T cells in HIV-1-infected patients with immune reconstitution inflammatory syndrome. Blood. 119: 3105-12. PMID 22219223 DOI: 10.1182/Blood-2011-09-380840  0.36
2011 Banchereau J, Cohn F, Inaba K, Muller B, Mellman I, Nathan C, Nussenzweig M, O'Garra A, Seder B, Schuler G, Sher A. Remembering Ralph Steinman. The Journal of Experimental Medicine. 208: 2343-7. PMID 22216461 DOI: 10.1084/Jem.20112295  0.36
2011 Mayer-Barber KD, Andrade BB, Barber DL, Hieny S, Feng CG, Caspar P, Oland S, Gordon S, Sher A. Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection. Immunity. 35: 1023-34. PMID 22195750 DOI: 10.1016/J.Immuni.2011.12.002  0.36
2011 Mashayekhi M, Sandau MM, Dunay IR, Frickel EM, Khan A, Goldszmid RS, Sher A, Ploegh HL, Murphy TL, Sibley LD, Murphy KM. CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity. 35: 249-59. PMID 21867928 DOI: 10.1016/J.Immuni.2011.08.008  0.36
2011 Novikov A, Cardone M, Thompson R, Shenderov K, Kirschman KD, Mayer-Barber KD, Myers TG, Rabin RL, Trinchieri G, Sher A, Feng CG. Mycobacterium tuberculosis triggers host type I IFN signaling to regulate IL-1β production in human macrophages. Journal of Immunology (Baltimore, Md. : 1950). 187: 2540-7. PMID 21784976 DOI: 10.4049/Jimmunol.1100926  0.36
2011 Egen JG, Rothfuchs AG, Feng CG, Horwitz MA, Sher A, Germain RN. Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas. Immunity. 34: 807-19. PMID 21596592 DOI: 10.1016/J.Immuni.2011.03.022  0.36
2011 Cooper AM, Mayer-Barber KD, Sher A. Role of innate cytokines in mycobacterial infection. Mucosal Immunology. 4: 252-60. PMID 21430655 DOI: 10.1038/Mi.2011.13  0.36
2011 Duggal P, Guo X, Haque R, Peterson KM, Ricklefs S, Mondal D, Alam F, Noor Z, Verkerke HP, Marie C, Leduc CA, Chua SC, Myers MG, Leibel RL, Houpt E, ... ... Sher A, et al. A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. The Journal of Clinical Investigation. 121: 1191-8. PMID 21393862 DOI: 10.1172/Jci45294  0.36
2011 Barber DL, Mayer-Barber KD, Feng CG, Sharpe AH, Sher A. CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition. Journal of Immunology (Baltimore, Md. : 1950). 186: 1598-607. PMID 21172867 DOI: 10.4049/Jimmunol.1003304  0.36
2011 Hunn JP, Feng CG, Sher A, Howard JC. The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 22: 43-54. PMID 21052678 DOI: 10.1007/S00335-010-9293-3  0.36
2011 Marakalala MJ, Guler R, Matika L, Murray G, Jacobs M, Brombacher F, Rothfuchs AG, Sher A, Brown GD. The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice. Microbes and Infection / Institut Pasteur. 13: 198-201. PMID 21034845 DOI: 10.1016/J.Micinf.2010.10.013  0.36
2010 Feng CG, Sher A. Parasites paralyze cellular host defense system to promote virulence. Cell Host & Microbe. 8: 463-4. PMID 21147459 DOI: 10.1016/J.Chom.2010.11.012  0.36
2010 Walseng E, Furuta K, Goldszmid RS, Weih KA, Sher A, Roche PA. Dendritic cell activation prevents MHC class II ubiquitination and promotes MHC class II survival regardless of the activation stimulus. The Journal of Biological Chemistry. 285: 41749-54. PMID 21047782 DOI: 10.1074/Jbc.M110.157586  0.36
2010 Coffman RL, Sher A, Seder RA. Vaccine adjuvants: putting innate immunity to work. Immunity. 33: 492-503. PMID 21029960 DOI: 10.1016/J.Immuni.2010.10.002  0.36
2010 Antonelli LR, Mahnke Y, Hodge JN, Porter BO, Barber DL, DerSimonian R, Greenwald JH, Roby G, Mican J, Sher A, Roederer M, Sereti I. Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome. Blood. 116: 3818-27. PMID 20660788 DOI: 10.1182/Blood-2010-05-285080  0.36
2010 Barber DL, Mayer-Barber KD, Antonelli LR, Wilson MS, White S, Caspar P, Hieny S, Sereti I, Sher A. Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice. Blood. 116: 3485-93. PMID 20656932 DOI: 10.1182/Blood-2010-05-286336  0.36
2010 Antonelli LR, Gigliotti Rothfuchs A, Gonçalves R, Roffê E, Cheever AW, Bafica A, Salazar AM, Feng CG, Sher A. Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population. The Journal of Clinical Investigation. 120: 1674-82. PMID 20389020 DOI: 10.1172/Jci40817  0.36
2010 Wilson MS, Feng CG, Barber DL, Yarovinsky F, Cheever AW, Sher A, Grigg M, Collins M, Fouser L, Wynn TA. Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections. Journal of Immunology (Baltimore, Md. : 1950). 184: 4378-90. PMID 20220096 DOI: 10.4049/Jimmunol.0903416  0.36
2010 Min-Oo G, Ayi K, Bongfen SE, Tam M, Radovanovic I, Gauthier S, Santiago H, Rothfuchs AG, Roffê E, Sher A, Mullick A, Fortin A, Stevenson MM, Kain KC, Gros P. Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium. Experimental Parasitology. 125: 315-24. PMID 20219464 DOI: 10.1016/J.Exppara.2010.02.009  0.36
2010 Mayer-Barber KD, Barber DL, Shenderov K, White SD, Wilson MS, Cheever A, Kugler D, Hieny S, Caspar P, Núñez G, Schlueter D, Flavell RA, Sutterwala FS, Sher A. Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. Journal of Immunology (Baltimore, Md. : 1950). 184: 3326-30. PMID 20200276 DOI: 10.4049/Jimmunol.0904189  0.36
2010 Goldszmid RS, Sher A. Processing and presentation of antigens derived from intracellular protozoan parasites. Current Opinion in Immunology. 22: 118-23. PMID 20153156 DOI: 10.1016/J.Coi.2010.01.017  0.36
2009 Steinfelder S, Andersen JF, Cannons JL, Feng CG, Joshi M, Dwyer D, Caspar P, Schwartzberg PL, Sher A, Jankovic D. The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1). The Journal of Experimental Medicine. 206: 1681-90. PMID 19635859 DOI: 10.1084/Jem.20082462  0.36
2009 la Sala A, He J, Laricchia-Robbio L, Gorini S, Iwasaki A, Braun M, Yap GS, Sher A, Ozato K, Kelsall B. Cholera toxin inhibits IL-12 production and CD8alpha+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function. The Journal of Experimental Medicine. 206: 1227-35. PMID 19487420 DOI: 10.1084/Jem.20080912  0.36
2009 Rothfuchs AG, Egen JG, Feng CG, Antonelli LR, Bafica A, Winter N, Locksley RM, Sher A. In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli. Journal of Immunology (Baltimore, Md. : 1950). 182: 6915-25. PMID 19454688 DOI: 10.4049/Jimmunol.0900074  0.36
2009 Henry SC, Daniell XG, Burroughs AR, Indaram M, Howell DN, Coers J, Starnbach MN, Hunn JP, Howard JC, Feng CG, Sher A, Taylor GA. Balance of Irgm protein activities determines IFN-gamma-induced host defense. Journal of Leukocyte Biology. 85: 877-85. PMID 19176402 DOI: 10.1189/Jlb.1008599  0.36
2009 Goldszmid RS, Coppens I, Lev A, Caspar P, Mellman I, Sher A. Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells. The Journal of Experimental Medicine. 206: 399-410. PMID 19153244 DOI: 10.1084/Jem.20082108  0.36
2009 La Sala A, He J, Laricchia-Robbio L, Gorini S, Iwasaki A, Braun M, Yap GS, Sher A, Ozato K, Kelsall B. Cholera toxin inhibits IL-12 production and CD8α+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function (Journal of Experimental Medicine (2009) 206, 6, (1227-1235)) Journal of Experimental Medicine. 206: 1635. DOI: 10.1084/Jem.2008091262209C  0.36
2008 Watford WT, Hissong BD, Durant LR, Yamane H, Muul LM, Kanno Y, Tato CM, Ramos HL, Berger AE, Mielke L, Pesu M, Solomon B, Frucht DM, Paul WE, Sher A, et al. Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii. The Journal of Experimental Medicine. 205: 2803-12. PMID 19001140 DOI: 10.1084/Jem.20081461  0.36
2008 Sahu N, Venegas AM, Jankovic D, Mitzner W, Gomez-Rodriguez J, Cannons JL, Sommers C, Love P, Sher A, Schwartzberg PL, August A. Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses. Journal of Immunology (Baltimore, Md. : 1950). 181: 6125-31. PMID 18941202 DOI: 10.4049/Jimmunol.181.9.6125  0.36
2008 Feng CG, Zheng L, Jankovic D, Báfica A, Cannons JL, Watford WT, Chaussabel D, Hieny S, Caspar P, Schwartzberg PL, Lenardo MJ, Sher A. The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nature Immunology. 9: 1279-87. PMID 18806793 DOI: 10.1038/Ni.1653  0.36
2007 Goldszmid RS, Bafica A, Jankovic D, Feng CG, Caspar P, Winkler-Pickett R, Trinchieri G, Sher A. TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production. The Journal of Experimental Medicine. 204: 2591-602. PMID 17923502 DOI: 10.1084/Jem.20070634  0.36
2007 Bafica A, Feng CG, Santiago HC, Aliberti J, Cheever A, Thomas KE, Taylor GA, Vogel SN, Sher A. The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia. Journal of Immunology (Baltimore, Md. : 1950). 179: 5514-22. PMID 17911638 DOI: 10.4049/Jimmunol.179.8.5514  0.36
2007 Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A. Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 179: 3463-71. PMID 17785780 DOI: 10.4049/Jimmunol.179.6.3463  0.36
2007 Trinchieri G, Sher A. Cooperation of Toll-like receptor signals in innate immune defence Nature Reviews Immunology. 7: 179-190. PMID 17318230 DOI: 10.1038/Nri2038  0.36
2007 Jankovic D, Kullberg MC, Feng CG, Goldszmid RS, Collazo CM, Wilson M, Wynn TA, Kamanaka M, Flavell RA, Sher A. Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. The Journal of Experimental Medicine. 204: 273-83. PMID 17283209 DOI: 10.1084/Jem.20062175  0.36
2007 Scanga CA, Bafica A, Sher A. Viral gene expression in HIV transgenic mice is activated by Mycobacterium tuberculosis and suppressed after antimycobacterial chemotherapy. The Journal of Infectious Diseases. 195: 246-54. PMID 17191170 DOI: 10.1086/510244  0.36
2006 Feng CG, Kaviratne M, Rothfuchs AG, Cheever A, Hieny S, Young HA, Wynn TA, Sher A. NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 177: 7086-93. PMID 17082625 DOI: 10.4049/Jimmunol.177.10.7086  0.36
2006 Kullberg MC, Jankovic D, Feng CG, Hue S, Gorelick PL, McKenzie BS, Cua DJ, Powrie F, Cheever AW, Maloy KJ, Sher A. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis Journal of Experimental Medicine. 203: 2485-2494. PMID 17030948 DOI: 10.1084/Jem.20061082  0.36
2006 Bertholet S, Goldszmid R, Morrot A, Debrabant A, Afrin F, Collazo-Custodio C, Houde M, Desjardins M, Sher A, Sacks D. Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivo Journal of Immunology. 177: 3525-3533. PMID 16951311 DOI: 10.4049/Jimmunol.177.6.3525  0.36
2006 Bafica A, Santiago HC, Goldszmid R, Ropert C, Gazzinelli RT, Sher A. Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection. Journal of Immunology (Baltimore, Md. : 1950). 177: 3515-9. PMID 16951309 DOI: 10.4049/Jimmunol.177.6.3515  0.36
2006 Cannons JL, Yu LJ, Jankovic D, Crotty S, Horai R, Kirby M, Anderson S, Cheever AW, Sher A, Schwartzberg PL. SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. The Journal of Experimental Medicine. 203: 1551-65. PMID 16754717 DOI: 10.1084/Jem.20052097  0.36
2006 Collazo CM, Sher A, Meierovics AI, Elkins KL. Myeloid differentiation factor-88 (MyD88) is essential for control of primary in vivo Francisella tularensis LVS infection, but not for control of intra-macrophage bacterial replication. Microbes and Infection / Institut Pasteur. 8: 779-90. PMID 16513388 DOI: 10.1016/J.Micinf.2005.09.014  0.36
2006 Yap GS, Shaw MH, Ling Y, Sher A. Genetic analysis of host resistance to intracellular pathogens: lessons from studies of Toxoplasma gondii infection. Microbes and Infection / Institut Pasteur. 8: 1174-8. PMID 16513380 DOI: 10.1016/J.Micinf.2005.10.031  0.36
2006 Yarovinsky F, Sher A. Toll-like receptor recognition of Toxoplasma gondii International Journal For Parasitology. 36: 255-259. PMID 16476433 DOI: 10.1016/J.Ijpara.2005.12.003  0.36
2005 Bafica A, Scanga CA, Feng CG, Leifer C, Cheever A, Sher A. TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis. The Journal of Experimental Medicine. 202: 1715-24. PMID 16365150 DOI: 10.1084/Jem.20051782  0.36
2005 Santiago HC, Feng CG, Bafica A, Roffe E, Arantes RM, Cheever A, Taylor G, Vieira LQ, Vierira LQ, Aliberti J, Gazzinelli RT, Sher A. Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth. Journal of Immunology (Baltimore, Md. : 1950). 175: 8165-72. PMID 16339555 DOI: 10.4049/Jimmunol.175.12.8165  0.36
2005 Golding H, Khurana S, Yarovinsky F, King LR, Abdoulaeva G, Antonsson L, Owman C, Platt EJ, Kabat D, Andersen JF, Sher A. CCR5 N-terminal region plays a critical role in HIV-1 inhibition by Toxoplasma gondii-derived cyclophilin-18. The Journal of Biological Chemistry. 280: 29570-7. PMID 15975927 DOI: 10.1074/Jbc.M500236200  0.36
2005 Bafica A, Scanga CA, Serhan C, Machado F, White S, Sher A, Aliberti J. Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production. The Journal of Clinical Investigation. 115: 1601-6. PMID 15931391 DOI: 10.1172/Jci23949  0.36
2005 Butcher BA, Greene RI, Henry SC, Annecharico KL, Weinberg JB, Denkers EY, Sher A, Taylor GA. p47 GTPases regulate Toxoplasma gondii survival in activated macrophages. Infection and Immunity. 73: 3278-86. PMID 15908352 DOI: 10.1128/Iai.73.6.3278-3286.2005  0.36
2005 Sher A, Kullberg M. Effector and regulatory CD4+ T cell function in a murine model of helicobacter hepaticus-induced colitis Journal of Pediatric Gastroenterology and Nutrition. 40. PMID 15805844 DOI: 10.1097/00005176-200504001-00021  0.36
2005 Feng CG, Jankovic D, Kullberg M, Cheever A, Scanga CA, Hieny S, Caspar P, Yap GS, Sher A. Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 production. Journal of Immunology (Baltimore, Md. : 1950). 174: 4185-92. PMID 15778379 DOI: 10.4049/Jimmunol.174.7.4185  0.36
2005 Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, Serhan CN. Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. The Journal of Experimental Medicine. 201: 713-22. PMID 15753205 DOI: 10.1084/Jem.20042031  0.36
2004 Báfica A, Scanga CA, Schito M, Chaussabel D, Sher A. Influence of coinfecting pathogens on HIV expression: evidence for a role of Toll-like receptors. Journal of Immunology (Baltimore, Md. : 1950). 172: 7229-34. PMID 15187096 DOI: 10.4049/Jimmunol.172.12.7229  0.36
2004 Del Rio L, Butcher BA, Bennouna S, Hieny S, Sher A, Denkers EY. Toxoplasma gondii triggers myeloid differentiation factor 88-dependent IL-12 and chemokine ligand 2 (monocyte chemoattractant protein 1) responses using distinct parasite molecules and host receptors. Journal of Immunology (Baltimore, Md. : 1950). 172: 6954-60. PMID 15153515 DOI: 10.4049/Jimmunol.172.11.6954  0.36
2004 Scanga CA, Bafica A, Feng CG, Cheever AW, Hieny S, Sher A. MyD88-deficient mice display a profound loss in resistance to Mycobacterium tuberculosis associated with partially impaired Th1 cytokine and nitric oxide synthase 2 expression. Infection and Immunity. 72: 2400-4. PMID 15039368 DOI: 10.1128/Iai.72.4.2400-2404.2004  0.36
2004 Báfica A, Scanga CA, Equils O, Sher A. The induction of Toll-like receptor tolerance enhances rather than suppresses HIV-1 gene expression in transgenic mice. Journal of Leukocyte Biology. 75: 460-6. PMID 14657211 DOI: 10.1189/Jlb.0803388  0.36
2003 Feng CG, Scanga CA, Collazo-Custodio CM, Cheever AW, Hieny S, Caspar P, Sher A. Mice lacking myeloid differentiation factor 88 display profound defects in host resistance and immune responses to Mycobacterium avium infection not exhibited by Toll-like receptor 2 (TLR2)- and TLR4-deficient animals. Journal of Immunology (Baltimore, Md. : 1950). 171: 4758-64. PMID 14568952 DOI: 10.4049/Jimmunol.171.9.4758  0.36
2003 Báfica A, Scanga CA, Schito ML, Hieny S, Sher A. Cutting edge: in vivo induction of integrated HIV-1 expression by mycobacteria is critically dependent on Toll-like receptor 2. Journal of Immunology (Baltimore, Md. : 1950). 171: 1123-7. PMID 12874196 DOI: 10.4049/Jimmunol.171.3.1123  0.36
2003 Equils O, Schito ML, Karahashi H, Madak Z, Yarali A, Michelsen KS, Sher A, Arditi M. Toll-like receptor 2 (TLR2) and TLR9 signaling results in HIV-long terminal repeat trans-activation and HIV replication in HIV-1 transgenic mouse spleen cells: implications of simultaneous activation of TLRs on HIV replication. Journal of Immunology (Baltimore, Md. : 1950). 170: 5159-64. PMID 12734363 DOI: 10.4049/Jimmunol.170.10.5159  0.36
2003 Aliberti J, Valenzuela JG, Carruthers VB, Hieny S, Andersen J, Charest H, Reis e Sousa C, Fairlamb A, Ribeiro JM, Sher A. Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells. Nature Immunology. 4: 485-90. PMID 12665855 DOI: 10.1038/Ni915  0.36
2003 Chaussabel D, Semnani RT, McDowell MA, Sacks D, Sher A, Nutman TB. Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites. Blood. 102: 672-81. PMID 12663451 DOI: 10.1182/Blood-2002-10-3232  0.36
2002 Ozaki K, Spolski R, Feng CG, Qi CF, Cheng J, Sher A, Morse HC, Liu C, Schwartzberg PL, Leonard WJ. A critical role for IL-21 in regulating immunoglobulin production. Science (New York, N.Y.). 298: 1630-4. PMID 12446913 DOI: 10.1126/Science.1077002  0.36
2002 Collazo CM, Yap GS, Hieny S, Caspar P, Feng CG, Taylor GA, Sher A. The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments. Infection and Immunity. 70: 6933-9. PMID 12438372 DOI: 10.1128/Iai.70.12.6933-6939.2002  0.36
2002 Sacks D, Sher A. Evasion of innate immunity by parasitic protozoa Nature Immunology. 3: 1041-1047. PMID 12407413 DOI: 10.1038/Ni1102-1041  0.36
2002 Chaussabel D, Sher A. Mining microarray expression data by literature profiling Genome Biology. 3. PMID 12372143 DOI: 10.1186/Gb-2002-3-10-Research0055  0.36
2002 Yap GS, Sher A. The use of germ line-mutated mice in understanding host-pathogen interactions. Cellular Microbiology. 4: 627-34. PMID 12366400 DOI: 10.1046/J.1462-5822.2002.00224.X  0.36
2002 Aliberti J, Sher A. Role of G-protein-coupled signaling in the induction and regulation of dendritic cell function by Toxoplasma gondii Microbes and Infection. 4: 991-997. PMID 12106793 DOI: 10.1016/S1286-4579(02)01618-0  0.36
2002 Scanga CA, Aliberti J, Jankovic D, Tilloy F, Bennouna S, Denkers EY, Medzhitov R, Sher A. Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 168: 5997-6001. PMID 12055206 DOI: 10.4049/Jimmunol.168.12.5997  0.36
2002 Aliberti J, Sher A. Positive and negative regulation of pathogen induced dendritic cell function by G-protein coupled receptors Molecular Immunology. 38: 891-893. PMID 12009566 DOI: 10.1016/S0161-5890(02)00015-9  0.36
2001 Marshall MA, Jankovic D, Ellen Maher V, Sher A, Berzofsky JA. Mice infected with Schistosoma mansoni develop a novel non-T-lymphocyte suppressor population which inhibits virus-specific CTL induction via a soluble factor Microbes and Infection. 3: 1051-1061. PMID 11709285 DOI: 10.1016/S1286-4579(01)01499-X  0.36
2001 Schaeffer EM, Yap GS, Lewis CM, Czar MJ, McVicar DW, Cheever AW, Sher A, Schwartzberg PL. Mutation of Tec family kinases alters T helper cell differentiation. Nature Immunology. 2: 1183-8. PMID 11702066 DOI: 10.1038/Ni734  0.36
2001 Collazo CM, Yap GS, Sempowski GD, Lusby KC, Tessarollo L, Vande Woude GF, Sher A, Taylor GA. Inactivation of LRG-47 and IRG-47 reveals a family of interferon γ-inducible genes with essential, pathogen-specific roles in resistance to infection Journal of Experimental Medicine. 194: 181-187. PMID 11457893 DOI: 10.1084/Jem.194.2.181  0.36
2001 Czar MJ, Kersh EN, Mijares LA, Lanier G, Lewis J, Yap G, Chen A, Sher A, Duckett CS, Ahmed R, Schwartzberg PL. Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP Proceedings of the National Academy of Sciences of the United States of America. 98: 7449-7454. PMID 11404475 DOI: 10.1073/Pnas.131193098  0.36
2001 Kullberg MC, Rothfuchs AG, Jankovic D, Caspar P, Wynn TA, Gorelick PL, Cheever AW, Sher A. Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: Cytokine requirements for the induction and maintenance of intestinal inflammation Infection and Immunity. 69: 4232-4241. PMID 11401959 DOI: 10.1128/Iai.69.7.4232-4241.2001  0.36
2001 Yap GS, Ortmann R, Shevach E, Sher A. A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatment Journal of Immunology. 166: 5720-5725. PMID 11313414 DOI: 10.4049/Jimmunol.166.9.5720  0.36
2001 Chougnet C, Freitag C, Schito M, Thomas EK, Sher A, Shearer GM. In vivo CD40-CD154 (CD40 ligand) interaction induces integrated HIV expression by APC in an HIV-1-transgenic mouse model. Journal of Immunology (Baltimore, Md. : 1950). 166: 3210-7. PMID 11207274 DOI: 10.4049/Jimmunol.166.5.3210  0.36
2000 Charest H, Sedegah M, Yap GS, Gazzinelli RT, Caspar P, Hoffman SL, Sher A. Recombinant attenuated Toxoplasma gondii expressing the Plasmodium yoelii circumsporozoite protein provides highly effective priming for CD8+ T cell-dependent protective immunity against malaria Journal of Immunology. 165: 2084-2092. PMID 10925293 DOI: 10.4049/Jimmunol.165.4.2084  0.36
2000 Aliberti J, Reis E Sousa C, Schito M, Hieny S, Wells T, Huffnagle GB, Sher A. CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells Nature Immunology. 1: 83-87. PMID 10881180 DOI: 10.1038/76957  0.36
2000 Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, Sher A, Littman DR. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Molecular and Cellular Biology. 20: 4106-14. PMID 10805752 DOI: 10.1128/Mcb.20.11.4106-4114.2000  0.36
2000 Taylor GA, Collazo CM, Yap GS, Nguyen K, Gregorio TA, Taylor LS, Eagleson B, Secrest L, Southon EA, Reid SW, Tessarollo L, Bray M, McVicar DW, Komschlies KL, Young HA, ... ... Sher A, et al. Pathogen-specific loss of host resistance in mice lacking the IFN-γ- inducible gene IGTP Proceedings of the National Academy of Sciences of the United States of America. 97: 751-755. PMID 10639151 DOI: 10.1073/Pnas.97.2.751  0.36
1999 Yap GS, Sher A. Cell-mediated immunity to Toxoplasma gondii: Initiation, regulation and effector function Immunobiology. 201: 240-247. PMID 10631573 DOI: 10.1016/S0171-2985(99)80064-3  0.36
1999 Mountford AP, Coulson PS, Cheever AW, Sher A, Wilson RA, Wynn TA. Interleukin-12 can directly induce T-helper 1 responses in interferon- γ (IFN-γ) receptor-deficient mice, but requires IFN-γ signalling to downregulate T-helper 2 responses Immunology. 97: 588-594. PMID 10457211 DOI: 10.1046/J.1365-2567.1999.00832.X  0.36
1999 Spriggs MK, Sher A. New lessons for immunology at the host-pathogen interface Current Opinion in Immunology. 11: 363-364. PMID 10448149 DOI: 10.1016/S0952-7915(99)80061-2  0.36
1999 Liesenfeld O, Kang H, Park D, Nguyen TA, Parkhe CV, Watanabe H, Abo T, Sher A, Remington JS, Suzuki Y. TNF-alpha, nitric oxide and IFN-gamma are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii. Parasite Immunology. 21: 365-76. PMID 10417671 DOI: 10.1046/J.1365-3024.1999.00237.X  0.36
1999 Schaeffer EM, Debnath J, Yap G, McVicar D, Liao XC, Littman DR, Sher A, Varmus HE, Lenardo MJ, Schwartzberg PL. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science (New York, N.Y.). 284: 638-41. PMID 10213685 DOI: 10.1126/Science.284.5414.638  0.36
1999 Yap GS, Sher A. Effector cells of both nonhemopoietic and hemopoietic origin are required for interferon (IFN)-γ- and tumor necrosis factor (TNF)-α- dependent host resistance to the intracellular pathogen, Toxoplasma gondii Journal of Experimental Medicine. 189: 1083-1091. PMID 10190899 DOI: 10.1084/Jem.189.7.1083  0.36
1998 Cheever AW, Jankovic D, Yap GS, Kullberg MC, Sher A, Wynn TA. Role of Cytokines in the Formation and Down regulation of Hepatic Circumoval Granulomas and Hepatic Fibrosis in Schistosoma mansoni-Infected Mice Memorias Do Instituto Oswaldo Cruz. 93: 25-32. PMID 9921320 DOI: 10.1590/S0074-02761998000700004  0.36
1998 Yap GS, Scharton-Kersten T, Ferguson DJP, Howe D, Suzuki Y, Sher A. Partially protective vaccination permits the development of latency in a normally virulent strain of Toxoplasma gondii Infection and Immunity. 66: 4382-4388. PMID 9712791 DOI: 10.1128/Iai.66.9.4382-4388.1998  0.36
1998 Oswald IP, Caspar P, Wynn TA, Scharton-Kersten T, Williams ME, Hieny S, Sher A, James SL. Failure of P strain mice to respond to vaccination against schistosomiasis correlates with impaired production of IL-12 and up-regulation of Th2 cytokines that inhibit macrophage activation. European Journal of Immunology. 28: 1762-72. PMID 9645357 DOI: 10.1002/(Sici)1521-4141(199806)28:06<1762::Aid-Immu1762>3.0.Co;2-J  0.36
1998 Jankovic D, Cheever AW, Kullberg MC, Wynn TA, Yap G, Caspar P, Lewis FA, Clynes R, Ravetch JV, Sher A. CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling Journal of Experimental Medicine. 187: 619-629. PMID 9463412 DOI: 10.1084/Jem.187.4.619  0.36
1997 Scharton-Kersten T, Contursi C, Masumi A, Sher A, Ozato K. Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction Journal of Experimental Medicine. 186: 1523-1534. PMID 9348310 DOI: 10.1084/Jem.186.9.1523  0.36
1997 Gazzinelli RT, Camargo MM, Almeida IC, Morita YS, Giraldo M, Acosta-Serrano A, Hieny S, Englund PT, Ferguson MA, Travassos LR, Sher A. Identification and characterization of protozoan products that trigger the synthesis of IL-12 by inflammatory macrophages. Chemical Immunology. 68: 136-52. PMID 9329220 DOI: 10.1159/000058689  0.36
1997 Denkers EY, Sher A. Role of natural killer and NK1+ T-cells in regulating cell-mediated immunity during Toxoplasma gondii infection Biochemical Society Transactions. 25: 699-703. PMID 9191186 DOI: 10.1042/Bst0250699  0.36
1997 Franzoso G, Carlson L, Scharton-Kersten T, Shores EW, Epstein S, Grinberg A, Tran T, Shacter E, Leonardi A, Anver M, Love P, Sher A, Siebenlist U. Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions Immunity. 6: 479-490. PMID 9133427 DOI: 10.1016/S1074-7613(00)80291-5  0.36
1996 Scharton-Kersten T, Caspar P, Sher A, Denkers EY. Toxoplasma gondii: Evidence for interleukin-12-dependent and -independent pathways of interferon-γ production induced by an attenuated parasite strain Experimental Parasitology. 84: 102-114. PMID 8932760 DOI: 10.1006/Expr.1996.0096  0.36
1996 Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes Nature. 383: 787-793. PMID 8893001 DOI: 10.1038/383787A0  0.36
1996 Gazzinelli RT, Amichay D, Sharton-Kersten T, Grunwald E, Farber JM, Sher A. Role of macrophage-derived cytokines in the induction and regulation of cell-mediated immunity to Toxoplasma gondii. Current Topics in Microbiology and Immunology. 219: 127-39. PMID 8791695 DOI: 10.1007/978-3-642-51014-4_12  0.36
1996 Denkers EY, Scharton-Kersten T, Barbieri S, Caspar P, Sher A. A role for CD4+NK1.1+ T lymphocytes as major histocompatibility complex class II independent helper cells in the generation of CD8+ effector function against intracellular infection Journal of Experimental Medicine. 184: 131-139. PMID 8691126 DOI: 10.1084/Jem.184.1.131  0.36
1996 Chougnet C, Wynn TA, Clerici M, Landay AL, Kessler HA, Rusnak J, Melcher GP, Sher A, Shearer GM. Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus Journal of Infectious Diseases. 174: 46-53. PMID 8656012 DOI: 10.1093/Infdis/174.1.46  0.36
1995 Wynn TA, Sher A. IL 12 as an adjuvant for vaccines designed to prevent infection and immunopathology by schistosomes Research in Immunology. 146: 582-590. PMID 8839165 DOI: 10.1016/0923-2494(96)83035-5  0.36
1995 Scharton-Kersten T, Denkers EY, Gazzinelli R, Sher A. Role of IL 12 in induction of cell-mediated immunity to Toxoplasma gondii Research in Immunology. 146: 539-545. PMID 8839159 DOI: 10.1016/0923-2494(96)83029-X  0.36
1995 Eltoum IA, Wynn TA, Poindexter RW, Finkelman FD, Lewis FA, Sher A, Cheever AW. Suppressive effect of interleukin-4 neutralization differs for granulomas around Schistosoma mansoni eggs injected into mice compared with those around eggs laid in infected mice Infection and Immunity. 63: 2532-2536. PMID 7790066 DOI: 10.1128/Iai.63.7.2532-2536.1995  0.36
1995 Fernandez-Botran R, Wynn TA, Hieny S, Caspar P, Chilton PM, Sher A. Linked in vivo expression of soluble interleukin-4 receptor and interleukin-4 in murine schistosomiasis European Journal of Immunology. 25: 649-656. PMID 7705393 DOI: 10.1002/Eji.1830250304  0.36
1995 Wynn TA, Cheever AW, Jankovic D, Poindexter RW, Caspar P, Lewis FA, Sher A. An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection Nature. 376: 594-596. PMID 7637808 DOI: 10.1038/376594A0  0.36
1994 Carrera L, Chiaramonte M, Kuhn R, Muller W, Sacks D, Sher A, Gazzinelli RT. Leishmania major and Toxoplasma gondii have opposite effects on cytokine synthesis by macrophages. MemóRias Do Instituto Oswaldo Cruz. 89: 649-50. PMID 8524067 DOI: 10.1590/S0074-02761994000400024  0.36
1994 Clerici M, Wynn TA, Berzofsky JA, Blatt SP, Hendrix CW, Sher A, Coffman RL, Shearer GM. Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus Journal of Clinical Investigation. 93: 768-775. PMID 8113410 DOI: 10.1172/Jci117031  0.36
1994 Denkers EY, Caspar P, Sher A. Toxoplasma gondii possesses a superantigen activity that selectively expands murine T cell receptor Vβ5-bearing CD8+ lymphocytes Journal of Experimental Medicine. 180: 985-994. PMID 8064244 DOI: 10.1084/Jem.180.3.985  0.36
1994 Williams ME, Montenegro S, Domingues AL, Wynn TA, Teixeira K, Mahanty S, Coutinho A, Sher A. Leukocytes of patients with Schistosoma mansoni respond with a Th2 pattern of cytokine production to mitogen or egg antigens but with a Th0 pattern to worm antigens. The Journal of Infectious Diseases. 170: 946-54. PMID 7930740 DOI: 10.1093/Infdis/170.4.946  0.36
1994 Wynn TA, Eltoum I, Oswald IP, Cheever AW, Sher A. Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology Journal of Experimental Medicine. 179: 1551-1561. PMID 7909326 DOI: 10.1084/Jem.179.5.1551  0.36
1994 Actor JK, Marshall MA, Eltoum IA, Buller RML, Berzofsky JA, Sher A. Increased susceptibility of mice infected with Schistosoma mansoni to recombinant vaccinia virus: Association of viral persistence with egg granuloma formation European Journal of Immunology. 24: 3050-3056. PMID 7805733 DOI: 10.1002/Eji.1830241220  0.36
1994 Oswald IP, Wynn TA, Sher A, James SL. NO as an affector molecule of parasite killing: modulation of its synthesis by cytokines Comparative Biochemistry and Physiology. Part C: Pharmacology. 108: 11-18. PMID 7520338 DOI: 10.1016/1367-8280(94)90083-3  0.36
1994 Oswald IP, Eltoum I, Wynn TA, Schwartz B, Caspar P, Paulin D, Sher A, James SL. Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide Proceedings of the National Academy of Sciences of the United States of America. 91: 999-1003. PMID 7508126 DOI: 10.1073/Pnas.91.3.999  0.36
1993 Oswald IP, Wynn TA, Williams ME, Eltoum I, Cheever AW, James SL, Sher A. Regulatory and immunopathological roles of IL4 in experimental schistosomiasis. Research in Immunology. 144: 643-8. PMID 8303083 DOI: 10.1016/S0923-2494(05)80020-3  0.36
1993 Denkers EY, Gazzinelli RT, Martin D, Sher A. Emergence of NK1.1+ cells as effectors of IFN-γ dependent immunity to Toxoplasma gondii in MHC class I-deficient mice Journal of Experimental Medicine. 178: 1465-1472. PMID 8228800 DOI: 10.1084/Jem.178.5.1465  0.36
1993 Gazzinelli RT, Hieny S, Wynn TA, Wolf S, Sher A. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell- deficient hosts Proceedings of the National Academy of Sciences of the United States of America. 90: 6115-6119. PMID 8100999 DOI: 10.1073/Pnas.90.13.6115  0.36
1993 Cheever AW, Xu Y, Sher A, Finkelman FD, Cox TM, Macedonia JG. Schistosoma japonicum-infected mice show reduced hepatic fibrosis and eosinophilia and selective inhibition of interleukin-5 secretion by CD4+ cells after treatment with anti-interleukin-2 antibodies. Infection and Immunity. 61: 1288-92. PMID 8095922 DOI: 10.1128/Iai.61.4.1288-1292.1993  0.36
1993 Denkers EY, Sher A, Gazzinelli RT. CD8+ T-cell interactions with Toxoplasma gondii: implications for processing of antigen for class-I-restricted recognition Research in Immunology. 144: 51-57. PMID 8095730 DOI: 10.1016/S0923-2494(05)80099-9  0.36
1993 Actor JK, Shirai M, Kullberg MC, Buller RML, Sher A, Berzofsky JA. Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance Proceedings of the National Academy of Sciences of the United States of America. 90: 948-952. PMID 8094248 DOI: 10.1073/Pnas.90.3.948  0.36
1992 Sher A. Parasitizing the cytokine system Nature. 356: 565-566. PMID 1560840 DOI: 10.1038/356565A0  0.36
1992 Oswald IP, Wynn TA, Sher A, James SL. Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor α required as a costimulatory factor for interferon γ-induced activation Proceedings of the National Academy of Sciences of the United States of America. 89: 8676-8680. PMID 1528880 DOI: 10.1073/Pnas.89.18.8676  0.36
1992 Sher A, Gazzinelli RT, Oswald IP, Clerici M, Kullberg M, Pearce EJ, Berzofsky JA, Mosmann TR, James SL, Morse HC, Shearer GM. Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection Immunological Reviews. 183-204. PMID 1354651 DOI: 10.1111/J.1600-065X.1992.Tb01414.X  0.36
1992 Cheever AW, Xu Y, Macedonia JG, Cox T, Hieny S, Sher A. The role of cytokines in the pathogenesis of hepatic granulomatous disease in Schistosoma mansoni infected mice. Memã³Rias Do Instituto Oswaldo Cruz. 87: 81-5. PMID 1343930 DOI: 10.1590/S0074-02761992000800011  0.36
1992 Gazzinelli RT, Hartley JW, Fredrickson TN, Chattopadhyay SK, Sher A, Morse HC. Opportunistic infections and retrovirus-induced immunodeficiency: studies of acute and chronic infections with Toxoplasma gondii in mice infected with LP-BM5 murine leukemia viruses. Infection and Immunity. 60: 4394-401. PMID 1328058 DOI: 10.1128/Iai.60.10.4394-4401.1992  0.36
1991 Cheever AW, Xu YH, Sher A, Macedonia JG. Analysis of egg granuloma formation in Schistosoma japonicum-infected mice treated with antibodies to interleukin-5 and gamma interferon. Infection and Immunity. 59: 4071-4. PMID 1834572 DOI: 10.1128/Iai.59.11.4071-4074.1991  0.36
1991 Finkelman FD, Pearce EJ, Urban JF, Sher A. Regulation and biological function of helminth-induced cytokine responses Immunology Today. 12. PMID 1829892 DOI: 10.1016/S0167-5699(05)80018-0  0.36
1991 Pearce EJ, Sher A. Functional dichotomy in the CD4+T cell response to Schistosoma mansoni Experimental Parasitology. 73: 110-116. PMID 1711476 DOI: 10.1016/0014-4894(91)90014-N  0.36
1991 Mosmann TR, Schumacher JH, Street NF, Budd R, O'Garra A, Fong TA, Bond MW, Moore KW, Sher A, Fiorentino DF. Diversity of cytokine synthesis and function of mouse CD4+ T cells. Immunological Reviews. 123: 209-29. PMID 1684780 DOI: 10.1111/J.1600-065X.1991.Tb00612.X  0.36
1991 Xu YH, Macedonia J, Sher A, Pearce E, Cheever AW. Dynamic analysis of splenic Th1 and Th2 lymphocyte functions in mice infected with Schistosoma japonicum. Infection and Immunity. 59: 2934-40. PMID 1679041 DOI: 10.1128/Iai.59.9.2934-2940.1991  0.36
1990 Pearce EJ, Sher A. Immunity to helminths Current Opinion in Immunology. 2: 375-379. PMID 2534502 DOI: 10.1016/0952-7915(89)90144-1  0.36
1990 James SL, Sher A. Cell-mediated immune response to schistosomiasis Current Topics in Microbiology and Immunology. 155: 21-31. PMID 2407432 DOI: 10.1007/978-3-642-74983-4_2  0.36
1990 Brindley PJ, Sher A. Immunological involvement in the efficacy of praziquantel Experimental Parasitology. 71: 245-248. PMID 2115457 DOI: 10.1016/0014-4894(90)90028-B  0.36
1988 Sher A, James S. Genetic control of vaccine-induced immunity against a parasitic helminth, Schistosoma mansoni Bioessays. 9: 163-166. PMID 3149197 DOI: 10.1002/Bies.950090506  0.36
1988 Kipnis TL, Joiner KA, da Silva WD, Rimoldi MT, Hammer CH, Sher A. Identification of membrane components of Trypanosoma cruzi modulators of complement system Memorias Do Instituto Oswaldo Cruz. 83: 571-575. PMID 2473383 DOI: 10.1590/S0074-02761988000500069  0.36
1987 Brindley PJ, Sher A. Anti-schistosomal drugs: observations on the mechanism of drug resistance to hycanthone, and on the involvement of host antibodies in the mode of action of praziquantel Memorias Do Instituto Oswaldo Cruz. 82: 157-161. PMID 3151089 DOI: 10.1590/S0074-02761987000800027  0.36
1985 Correa-Oliveira R, Sher A. Defective immunoglobulin M responses to vaccination or infection with Schistosoma mansoni in xid mice Infection and Immunity. 50: 409-414. PMID 3932208 DOI: 10.1128/Iai.50.2.409-414.1985  0.36
1984 Sher A, Sacks DL, Simpson AJ, Singer A. Dichotomy in the tissue origin of schistosome acquired class I and class II major histocompatibility complex antigens. The Journal of Experimental Medicine. 159: 952-7. PMID 6366108 DOI: 10.1084/Jem.159.3.952  0.36
1983 Cheever AW, Hieny S, Duvall RH, Sher A. Lack of resistance to Schistosoma japonicum in mice immunized with irradiated S. mansoni cercariae. Transactions of the Royal Society of Tropical Medicine and Hygiene. 77: 812-4. PMID 6665834 DOI: 10.1016/0035-9203(83)90295-X  0.36
1983 James SL, Sher A. Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. III. Identification of a mouse strain, P/N, that fails to respond to vaccination Parasite Immunology. 5: 567-575. PMID 6657295 DOI: 10.1111/J.1365-3024.1983.Tb00773.X  0.36
1982 Sher A, Benno D. Decreasing immunogenicity of developing schistosome larvae Parasite Immunology. 4: 101-107. PMID 7070833 DOI: 10.1111/J.1365-3024.1982.Tb00423.X  0.36
1982 Sacks DL, Esser KM, Sher A. Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies. The Journal of Experimental Medicine. 155: 1108-19. PMID 6977615 DOI: 10.1084/Jem.155.4.1108  0.36
1982 Sher A, Snary D. Specific inhibition of the morphogenesis of Trypanosoma cruzi by a monoclonal antibody Nature. 300: 639-640. PMID 6755270 DOI: 10.1038/300639A0  0.36
1982 Lazdins JK, Stein MJ, David JR, Sher A. Schistosoma mansoni: rapid isolation and purification of schistosomula of different developmental stages by centrifugation on discontinuous density gradients of Percoll. Experimental Parasitology. 53: 39-44. PMID 6276213 DOI: 10.1016/0014-4894(82)90090-X  0.36
1981 Miller KL, Smithers SR, Sher A. The response of mice immune to Schistosoma mansoni to a challenge infection which bypasses the skin: Evidence for two mechanisms of immunity Parasite Immunology. 3: 25-31. PMID 7012761 DOI: 10.1111/J.1365-3024.1981.Tb00382.X  0.36
1977 Sher A. Immunity against Schistosoma mansoni in the mouse American Journal of Tropical Medicine and Hygiene. 26: 20-28. PMID 596522 DOI: 10.4269/Ajtmh.1977.26.20  0.36
1976 Sher A. Complement-dependent adherence of mast cells to schistosomula Nature. 263: 334-336. PMID 958490 DOI: 10.1038/263334A0  0.36
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