| Year |
Citation |
Score |
| 2022 |
Rey J, Breiden M, Lux V, Bluemke A, Steindel M, Ripkens K, Möllers B, Bravo Rodriguez K, Boisguerin P, Volkmer R, Mieres-Perez J, Clausen T, Sanchez-Garcia E, Ehrmann M. An allosteric HTRA1-calpain 2 complex with restricted activation profile. Proceedings of the National Academy of Sciences of the United States of America. 119: e2113520119. PMID 35349341 DOI: 10.1073/pnas.2113520119 |
0.677 |
|
| 2020 |
Merdanovic M, Burston SG, Schmitz AL, Köcher S, Knapp S, Clausen T, Kaiser M, Huber R, Ehrmann M. Activation by substoichiometric inhibition. Proceedings of the National Academy of Sciences of the United States of America. PMID 31907318 DOI: 10.1073/Pnas.1918721117 |
0.653 |
|
| 2015 |
Poepsel S, Sprengel A, Sacca B, Kaschani F, Kaiser M, Gatsogiannis C, Raunser S, Clausen T, Ehrmann M. Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nature Chemical Biology. 11: 862-9. PMID 26436840 DOI: 10.1038/nchembio.1931 |
0.651 |
|
| 2014 |
Beaufort N, Scharrer E, Kremmer E, Lux V, Ehrmann M, Huber R, Houlden H, Werring D, Haffner C, Dichgans M. Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling. Proceedings of the National Academy of Sciences of the United States of America. 111: 16496-501. PMID 25369932 DOI: 10.1073/Pnas.1418087111 |
0.365 |
|
| 2013 |
Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodrigues CD, Rudner DZ, Clausen T. CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis. Cell. 155: 647-58. PMID 24243021 DOI: 10.1016/j.cell.2013.09.050 |
0.637 |
|
| 2012 |
Tennstaedt A, Pöpsel S, Truebestein L, Hauske P, Brockmann A, Schmidt N, Irle I, Sacca B, Niemeyer CM, Brandt R, Ksiezak-Reding H, Tirniceriu AL, Egensperger R, Baldi A, Dehmelt L, ... ... Ehrmann M, et al. Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates. The Journal of Biological Chemistry. 287: 20931-41. PMID 22535953 DOI: 10.1074/Jbc.M111.316232 |
0.702 |
|
| 2012 |
Weski J, Ehrmann M. Genetic analysis of 15 protein folding factors and proteases of the Escherichia coli cell envelope. Journal of Bacteriology. 194: 3225-33. PMID 22505681 DOI: 10.1128/JB.00221-12 |
0.345 |
|
| 2012 |
Weski J, Meltzer M, Spaan L, Mönig T, Oeljeklaus J, Hauske P, Vouilleme L, Volkmer R, Boisguerin P, Boyd D, Huber R, Kaiser M, Ehrmann M. Chemical biology approaches reveal conserved features of a C-terminal processing PDZ protease. Chembiochem : a European Journal of Chemical Biology. 13: 402-8. PMID 22267294 DOI: 10.1002/Cbic.201100643 |
0.507 |
|
| 2012 |
Malet H, Canellas F, Sawa J, Yan J, Thalassinos K, Ehrmann M, Clausen T, Saibil HR. Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ. Nature Structural & Molecular Biology. 19: 152-7. PMID 22245966 DOI: 10.1038/nsmb.2210 |
0.688 |
|
| 2011 |
Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, et al. Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. Journal of the American Chemical Society. 133: 16958-69. PMID 21916458 DOI: 10.1021/Ja206279B |
0.323 |
|
| 2011 |
Sawa J, Malet H, Krojer T, Canellas F, Ehrmann M, Clausen T. Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope. The Journal of Biological Chemistry. 286: 30680-30690. PMID 21685389 DOI: 10.1074/jbc.M111.243832 |
0.688 |
|
| 2011 |
Merdanovic M, Clausen T, Kaiser M, Huber R, Ehrmann M. Protein quality control in the bacterial periplasm. Annual Review of Microbiology. 65: 149-68. PMID 21639788 DOI: 10.1146/Annurev-Micro-090110-102925 |
0.702 |
|
| 2011 |
Kley J, Schmidt B, Boyanov B, Stolt-Bergner PC, Kirk R, Ehrmann M, Knopf RR, Naveh L, Adam Z, Clausen T. Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure. Nature Structural & Molecular Biology. 18: 728-31. PMID 21532594 DOI: 10.1038/nsmb.2055 |
0.592 |
|
| 2011 |
Clausen T, Kaiser M, Huber R, Ehrmann M. HTRA proteases: regulated proteolysis in protein quality control. Nature Reviews. Molecular Cell Biology. 12: 152-62. PMID 21326199 DOI: 10.1038/Nrm3065 |
0.715 |
|
| 2011 |
Truebestein L, Tennstaedt A, Mönig T, Krojer T, Canellas F, Kaiser M, Clausen T, Ehrmann M. Substrate-induced remodeling of the active site regulates human HTRA1 activity. Nature Structural & Molecular Biology. 18: 386-8. PMID 21297635 DOI: 10.1038/nsmb.2013 |
0.644 |
|
| 2010 |
Merdanovic M, Mamant N, Meltzer M, Poepsel S, Auckenthaler A, Melgaard R, Hauske P, Nagel-Steger L, Clarke AR, Kaiser M, Huber R, Ehrmann M. Determinants of structural and functional plasticity of a widely conserved protease chaperone complex. Nature Structural & Molecular Biology. 17: 837-43. PMID 20581826 DOI: 10.1038/Nsmb.1839 |
0.575 |
|
| 2010 |
Sawa J, Heuck A, Ehrmann M, Clausen T. Molecular transformers in the cell: lessons learned from the DegP protease-chaperone. Current Opinion in Structural Biology. 20: 253-8. PMID 20188538 DOI: 10.1016/j.sbi.2010.01.014 |
0.673 |
|
| 2010 |
Hasenbein S, Meltzer M, Hauske P, Kaiser M, Huber R, Clausen T, Ehrmann M. Conversion of a regulatory into a degradative protease. Journal of Molecular Biology. 397: 957-66. PMID 20184896 DOI: 10.1016/J.Jmb.2010.02.027 |
0.693 |
|
| 2009 |
Meltzer M, Hasenbein S, Mamant N, Merdanovic M, Poepsel S, Hauske P, Kaiser M, Huber R, Krojer T, Clausen T, Ehrmann M. Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli. Research in Microbiology. 160: 660-6. PMID 19695325 DOI: 10.1016/J.Resmic.2009.07.012 |
0.706 |
|
| 2009 |
Hauske P, Mamant N, Hasenbein S, Nickel S, Ottmann C, Clausen T, Ehrmann M, Kaiser M. Peptidic small molecule activators of the stress sensor DegS. Molecular Biosystems. 5: 980-5. PMID 19668863 DOI: 10.1039/b902089f |
0.653 |
|
| 2009 |
Hauske P, Meltzer M, Ottmann C, Krojer T, Clausen T, Ehrmann M, Kaiser M. Selectivity profiling of DegP substrates and inhibitors. Bioorganic & Medicinal Chemistry. 17: 2920-4. PMID 19233659 DOI: 10.1016/j.bmc.2009.01.073 |
0.635 |
|
| 2008 |
Krojer T, Pangerl K, Kurt J, Sawa J, Stingl C, Mechtler K, Huber R, Ehrmann M, Clausen T. Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins Proceedings of the National Academy of Sciences of the United States of America. 105: 7702-7707. PMID 18505836 DOI: 10.1073/Pnas.0803392105 |
0.744 |
|
| 2008 |
Krojer T, Sawa J, Schäfer E, Saibil HR, Ehrmann M, Clausen T. Structural basis for the regulated protease and chaperone function of DegP. Nature. 453: 885-90. PMID 18496527 DOI: 10.1038/nature07004 |
0.696 |
|
| 2008 |
Meltzer M, Hasenbein S, Hauske P, Kucz N, Merdanovic M, Grau S, Beil A, Jones D, Krojer T, Clausen T, Ehrmann M, Kaiser M. Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control. Angewandte Chemie (International Ed. in English). 47: 1332-4. PMID 18175296 DOI: 10.1002/anie.200703273 |
0.639 |
|
| 2007 |
Hasselblatt H, Kurzbauer R, Wilken C, Krojer T, Sawa J, Kurt J, Kirk R, Hasenbein S, Ehrmann M, Clausen T. Regulation of the σE stress response by DegS: How the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress Genes and Development. 21: 2659-2670. PMID 17938245 DOI: 10.1101/gad.445307 |
0.633 |
|
| 2007 |
Eser M, Henrichs T, Boyd D, Ehrmann M. Target-directed proteolysis in vivo. Methods in Enzymology. 421: 68-83. PMID 17352916 DOI: 10.1016/S0076-6879(06)21008-5 |
0.364 |
|
| 2006 |
Grau S, Richards PJ, Kerr B, Hughes C, Caterson B, Williams AS, Junker U, Jones SA, Clausen T, Ehrmann M. The role of human HtrA1 in arthritic disease. The Journal of Biological Chemistry. 281: 6124-9. PMID 16377621 DOI: 10.1074/jbc.M500361200 |
0.591 |
|
| 2005 |
Grau S, Baldi A, Bussani R, Tian X, Stefanescu R, Przybylski M, Richards P, Jones SA, Shridhar V, Clausen T, Ehrmann M. Implications of the serine protease HtrA1 in amyloid precursor protein processing Proceedings of the National Academy of Sciences of the United States of America. 102: 6021-6026. PMID 15855271 DOI: 10.1073/pnas.0501823102 |
0.638 |
|
| 2005 |
Henrichs T, Mikhaleva N, Conz C, Deuerling E, Boyd D, Zelazny A, Bibi E, Ban N, Ehrmann M. Target-directed proteolysis at the ribosome. Proceedings of the National Academy of Sciences of the United States of America. 102: 4246-51. PMID 15784745 DOI: 10.1073/Pnas.0408520102 |
0.342 |
|
| 2004 |
Harnasch M, Grau S, Behrends C, Dove SL, Hochschild A, Iskandar MK, Xia W, Ehrmann M. Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins. Molecular Membrane Biology. 21: 373-83. PMID 15764367 DOI: 10.1080/09687860400008429 |
0.331 |
|
| 2004 |
Ehrmann M, Clausen T. Proteolysis as a regulatory mechanism. Annual Review of Genetics. 38: 709-24. PMID 15568990 DOI: 10.1146/annurev.genet.38.072902.093416 |
0.635 |
|
| 2004 |
Wilken C, Kitzing K, Kurzbauer R, Ehrmann M, Clausen T. Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease. Cell. 117: 483-94. PMID 15137941 DOI: 10.1016/s0092-8674(04)00454-4 |
0.683 |
|
| 2003 |
Eser M, Ehrmann M. SecA-dependent quality control of intracellular protein localization. Proceedings of the National Academy of Sciences of the United States of America. 100: 13231-4. PMID 14597695 DOI: 10.1073/pnas.2234410100 |
0.405 |
|
| 2002 |
Clausen T, Southan C, Ehrmann M. The HtrA family of proteases: implications for protein composition and cell fate. Molecular Cell. 10: 443-55. PMID 12408815 DOI: 10.1016/S1097-2765(02)00658-5 |
0.678 |
|
| 2002 |
Krojer T, Garrido-Franco M, Huber R, Ehrmann M, Clausen T. Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine Nature. 416: 455-459. PMID 11919638 DOI: 10.1038/416455A |
0.695 |
|
| 2002 |
Krojer T, Garrido-Franco M, Huber R, Ehrmann M, Clausen T. Erratum: corrigendum: Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine Nature. 417: 102-102. DOI: 10.1038/417102c |
0.59 |
|
| 2001 |
Faber KN, Kram AM, Ehrmann M, Veenhuis M. A novel method to determine the topology of peroxisomal membrane proteins in vivo using the tobacco etch virus protease. The Journal of Biological Chemistry. 276: 36501-7. PMID 11443138 DOI: 10.1074/JBC.M105828200 |
0.333 |
|
| 2000 |
Uhland K, Mondigler M, Spiess C, Prinz W, Ehrmann M. Determinants of translocation and folding of TreF, a trehalase of Escherichia coli. The Journal of Biological Chemistry. 275: 23439-45. PMID 10816581 DOI: 10.1074/Jbc.M002793200 |
0.345 |
|
| 1999 |
Spiess C, Beil A, Ehrmann M. A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein. Cell. 97: 339-47. PMID 10319814 DOI: 10.1016/S0092-8674(00)80743-6 |
0.369 |
|
| 1998 |
Ehrmann M, Ehrle R, Hofmann E, Boos W, Schlösser A. The ABC maltose transporter. Molecular Microbiology. 29: 685-94. PMID 9723909 DOI: 10.1046/J.1365-2958.1998.00915.X |
0.478 |
|
| 1998 |
Akiyama Y, Ehrmann M, Kihara A, Ito K. Polypeptide binding of Escherichia coli FtsH (HflB). Molecular Microbiology. 28: 803-12. PMID 9643547 DOI: 10.1046/j.1365-2958.1998.00843.x |
0.314 |
|
| 1998 |
Prinz WA, Boyd DH, Ehrmann M, Beckwith J. The protein translocation apparatus contributes to determining the topology of an integral membrane protein in Escherichia coli. The Journal of Biological Chemistry. 273: 8419-24. PMID 9525953 DOI: 10.1074/jbc.273.14.8419 |
0.332 |
|
| 1998 |
Ehrmann M, Bolek P, Mondigler M, Boyd D, Lange R. TnTIN and TnTAP: mini-transposons for site-specific proteolysis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 94: 13111-5. PMID 9371808 DOI: 10.1073/PNAS.94.24.13111 |
0.378 |
|
| 1996 |
Prinz WA, Spiess C, Ehrmann M, Schierle C, Beckwith J. Targeting of signal sequenceless proteins for export in Escherichia coli with altered protein translocase. The Embo Journal. 15: 5209-17. PMID 8895566 |
0.312 |
|
| 1996 |
Horlacher R, Uhland K, Klein W, Ehrmann M, Boos W. Characterization of a cytoplasmic trehalase of Escherichia coli. Journal of Bacteriology. 178: 6250-7. PMID 8892826 DOI: 10.1128/Jb.178.21.6250-6257.1996 |
0.499 |
|
| 1995 |
Uhland K, Zander T, Ehrmann M. Synthetic competition between cytoplasmic folding and translocation of a soluble membrane protein domain. Research in Microbiology. 146: 121-8. PMID 7652206 DOI: 10.1016/0923-2508(96)80890-4 |
0.315 |
|
| 1994 |
Hoffmann R, Jung S, Ehrmann M, Hofer HW. The Saccharomyces cerevisiae gene PPH3 encodes a protein phosphatase with properties different from PPX, PP1 and PP2A. Yeast (Chichester, England). 10: 567-78. PMID 7941742 DOI: 10.1002/YEA.320100502 |
0.335 |
|
| 1990 |
Ehrmann M, Boyd D, Beckwith J. Genetic analysis of membrane protein topology by a sandwich gene fusion approach. Proceedings of the National Academy of Sciences of the United States of America. 87: 7574-7578. PMID 2170984 DOI: 10.1073/Pnas.87.19.7574 |
0.597 |
|
| 1989 |
Reidl J, Römisch K, Ehrmann M, Boos W. MalI, a novel protein involved in regulation of the maltose system of Escherichia coli, is highly homologous to the repressor proteins GalR, CytR, and LacI Journal of Bacteriology. 171: 4888-4899. PMID 2670898 DOI: 10.1128/Jb.171.9.4888-4899.1989 |
0.591 |
|
| 1988 |
Gött P, Ehrmann M, Boos W. Convenient transfer of lacZ-gene fusions to phage M13 by in vivo recombination and their use for nucleotide sequencing Gene. 71: 187-191. PMID 2850975 DOI: 10.1016/0378-1119(88)90090-X |
0.44 |
|
| 1987 |
Ehrmann M, Boos W. Identification of endogenous inducers of the mal regulon in Escherichia coli Journal of Bacteriology. 169: 3539-3545. PMID 3038842 DOI: 10.1128/Jb.169.8.3539-3545.1987 |
0.468 |
|
| 1987 |
Ehrmann M, Boos W, Ormseth E, Schweizer H, Larson TJ. Divergent transcription of the sn-glycerol-3-phosphate active transport (glpT) and anaerobic sn-glycerol-3-phosphate dehydrogenase (glpA glpC glpB) genes of Escherichia coli K-12 Journal of Bacteriology. 169: 526-532. PMID 3027032 DOI: 10.1128/Jb.169.2.526-532.1987 |
0.459 |
|
| 1986 |
Bukau B, Ehrmann M, Boos W. Osmoregulation of the maltose regulon in Escherichia coli. Journal of Bacteriology. 166: 884-91. PMID 2423504 DOI: 10.1128/Jb.166.3.884-891.1986 |
0.634 |
|
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