Tasuku Honjo

Affiliations: 
1979-1984 Genetics Osaka University Medical School 
 1984-2005 Medical Chemistry Kyoto University, Kyōto-shi, Kyōto-fu, Japan 
Area:
Molecular Immunology
Website:
https://kuias.kyoto-u.ac.jp/e/profile/honjo/
Google:
"Tasuku Honjo"
Bio:

The Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation"
http://www2.mfour.med.kyoto-u.ac.jp/en/E_CV.html

Cross-listing: Neurotree

Parents

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Osamu Hayaishi grad student 1967-1971 Kyoto University (Neurotree)
Yasutomi Nishizuka grad student 1967-1971 Kyoto University (Chemistry Tree)
Donald D. Brown post-doc 1971-1973 The Carnegie Institute (DevTree)
Philip Leder post-doc 1973-1974 NIH (Neurotree)

Children

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Koichi Ikuta grad student 1983-1987 Kyoto University (Stem Cell Tree)
Shigeru Kondo research scientist Kyoto University (Neurotree)
Yasuyoshi Nishida research scientist (Neurotree)
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Publications

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Akrami M, Menzies R, Chamoto K, et al. (2020) Circulation of gut-preactivated naïve CD8 T cells enhances antitumor immunity in B cell-defective mice. Proceedings of the National Academy of Sciences of the United States of America
Husain A, Xu J, Fujii H, et al. (2020) SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination. The Embo Journal. e102931
Islam H, Kobayashi M, Honjo T. (2019) Apurinic/apyrimidinic endonuclease 1 (APE1) is dispensable for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation in the immunoglobulin gene. International Immunology
Al Ismail A, Husain A, Kobayashi M, et al. (2017) Depletion of recombination specific co-factors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination. International Immunology
McDonald G, Medina CO, Pilichowska M, et al. (2017) Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes. Frontiers in Immunology. 8: 1094
Zhang B, Chikuma S, Hori S, et al. (2016) Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model. Proceedings of the National Academy of Sciences of the United States of America
Mondal S, Begum NA, Hu W, et al. (2016) Functional requirements of AID's higher order structures and their interaction with RNA-binding proteins. Proceedings of the National Academy of Sciences of the United States of America
Husain A, Begum NA, Taniguchi T, et al. (2016) Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability. Nature Communications. 7: 10549
Hu W, Begum NA, Mondal S, et al. (2015) Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase. Proceedings of the National Academy of Sciences of the United States of America. 112: 5791-6
Xu J, Husain A, Hu W, et al. (2014) APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. 111: 17242-7
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