| Year |
Citation |
Score |
| 2023 |
Sun C, Zhou K, DePaola P, Shin W, Hillyer T, Sawaya M, Zhu R, Peng C, Zhou ZH, Jiang L. Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation reveals a distinct protofilament interface. The Journal of Biological Chemistry. 104566. PMID 36871760 DOI: 10.1016/j.jbc.2023.104566 |
0.671 |
|
| 2021 |
Zhang S, Liu YQ, Jia C, Lim YJ, Feng G, Xu E, Long H, Kimura Y, Tao Y, Zhao C, Wang C, Liu Z, Hu JJ, Ma MR, Liu Z, ... Jiang L, et al. Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34172566 DOI: 10.1073/pnas.2011196118 |
0.541 |
|
| 2021 |
Zhang S, Liu YQ, Jia C, Lim YJ, Feng G, Xu E, Long H, Kimura Y, Tao Y, Zhao C, Wang C, Liu Z, Hu JJ, Ma MR, Liu Z, ... Jiang L, et al. Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34172566 DOI: 10.1073/pnas.2011196118 |
0.541 |
|
| 2021 |
Shin WS, Di J, Cao Q, Li B, Seidler PM, Murray KA, Bitan G, Jiang L. Correction to: Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation. Alzheimer's Research & Therapy. 13: 83. PMID 33879220 DOI: 10.1186/s13195-021-00824-5 |
0.678 |
|
| 2020 |
Ma X, Zhu Y, Lu J, Xie J, Li C, Shin WS, Qiang J, Liu J, Dou S, Xiao Y, Wang C, Jia C, Long H, Yang J, Fang Y, ... Jiang L, et al. Nicotinamide mononucleotide adenylyltransferase uses its NAD substrate-binding site to chaperone phosphorylated Tau. Elife. 9. PMID 32250733 DOI: 10.7554/Elife.51859 |
0.708 |
|
| 2020 |
Boyer DR, Li B, Sun C, Fan W, Zhou K, Hughes MP, Sawaya MR, Jiang L, Eisenberg DS. The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure. Proceedings of the National Academy of Sciences of the United States of America. PMID 32015135 DOI: 10.1073/Pnas.1917914117 |
0.324 |
|
| 2020 |
Sangwan S, Sahay S, Murray KA, Morgan S, Guenther EL, Jiang L, Williams CK, Vinters HV, Goedert M, Eisenberg DS. Inhibition of synucleinopathic seeding by rationally designed inhibitors. Elife. 9. PMID 31895037 DOI: 10.7554/Elife.46775 |
0.339 |
|
| 2019 |
Shin WS, Di J, Murray KA, Sun C, Li B, Bitan G, Jiang L. Different Amyloid-β Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation. Frontiers in Molecular Neuroscience. 12: 268. PMID 31787880 DOI: 10.3389/Fnmol.2019.00268 |
0.695 |
|
| 2019 |
Boyer DR, Li B, Sun C, Fan W, Sawaya MR, Jiang L, Eisenberg DS. Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nature Structural & Molecular Biology. PMID 31695184 DOI: 10.1038/S41594-019-0322-Y |
0.336 |
|
| 2019 |
Shin WS, Di J, Cao Q, Li B, Seidler PM, Murray KA, Bitan G, Jiang L. Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation. Alzheimer's Research & Therapy. 11: 86. PMID 31627745 DOI: 10.1186/S13195-019-0541-9 |
0.696 |
|
| 2019 |
Hayden EY, Putman J, Nunez S, Shin WS, Oberoi M, Charreton M, Dutta S, Li Z, Komuro Y, Joy MT, Bitan G, MacKenzie-Graham A, Jiang L, Hinman JD. Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation. Acta Neuropathologica Communications. 7: 135. PMID 31429800 DOI: 10.1186/S40478-019-0783-6 |
0.661 |
|
| 2019 |
Gui X, Luo F, Li Y, Zhou H, Qin Z, Liu Z, Gu J, Xie M, Zhao K, Dai B, Shin WS, He J, He L, Jiang L, Zhao M, et al. Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly. Nature Communications. 10: 2006. PMID 31043593 DOI: 10.1038/S41467-019-09902-7 |
0.694 |
|
| 2019 |
Lu J, Cao Q, Wang C, Zheng J, Luo F, Xie J, Li Y, Ma X, He L, Eisenberg D, Nowick J, Jiang L, Li D. Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation. Frontiers in Molecular Neuroscience. 12: 54. PMID 30886570 DOI: 10.3389/Fnmol.2019.00054 |
0.376 |
|
| 2019 |
Jiang L, Cao Q, Shin WS, Eisenberg DS. O4-01-01: Inhibiting Amyloid-Beta Cytotoxicity Through Its Interaction With The Cell Surface Receptor Lilrb2 By Structure-Based Design Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4740 |
0.305 |
|
| 2019 |
Shin WS, Bitan G, Jiang L. F2-06-03: AMYLOID β-PROTEIN OLIGOMERS PROMOTE THE UPTAKE OF TAU FIBRIL SEEDS POTENTIATING INTRACELLULAR TAU AGGREGATION Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4438 |
0.314 |
|
| 2018 |
Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L. Author Correction: Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nature Chemistry. PMID 30420778 DOI: 10.1038/S41557-018-0182-9 |
0.685 |
|
| 2018 |
Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L. Inhibiting amyloid-ß cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nature Chemistry. PMID 30297750 DOI: 10.1038/S41557-018-0147-Z |
0.707 |
|
| 2018 |
Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer DR, Ye S, Eisenberg DS, Zhou ZH, Jiang L. Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel. Nature Communications. 9: 3609. PMID 30190461 DOI: 10.1038/s41467-018-05971-2 |
0.68 |
|
| 2018 |
Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer DR, Ye S, Eisenberg DS, Zhou ZH, Jiang L. Cryo-EM of full-length alpha-synuclein reveals fibril polymorphs with a common structural kernel. Nature Communications. 9: 3609-3609. DOI: 10.2210/Pdb6Cu7/Pdb |
0.336 |
|
| 2017 |
Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. Common fibrillar spines of amyloid-β and human Islet Amyloid Polypeptide revealed by Micro Electron Diffraction and inhibitors developed using structure-based design. The Journal of Biological Chemistry. PMID 29282295 DOI: 10.1074/Jbc.M117.806109 |
0.359 |
|
| 2017 |
Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, et al. Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity. Elife. 6. PMID 28045370 DOI: 10.7554/Elife.19273 |
0.308 |
|
| 2016 |
Gu L, Tran J, Jiang L, Guo Z. A new structural model of Alzheimer's Aβ42 fibrils based on electron paramagnetic resonance data and Rosetta modeling. Journal of Structural Biology. PMID 26827680 DOI: 10.1016/J.Jsb.2016.01.013 |
0.363 |
|
| 2016 |
Yang G, Zhang X, Kochovski Z, Zhang Y, Dai B, Sakai F, Jiang L, Lu Y, Ballauff M, Li X, Liu C, Chen G, Jiang M. Precise and reversible protein microtubule-like structure with helicity driven by dual supramolecular interactions. Journal of the American Chemical Society. PMID 26799414 DOI: 10.1021/Jacs.5B11733 |
0.374 |
|
| 2015 |
Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS. Uncovering the Mechanism of Aggregation of Human Transthyretin. The Journal of Biological Chemistry. PMID 26459562 DOI: 10.1074/Jbc.M115.659912 |
0.338 |
|
| 2015 |
Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, et al. Structure of the toxic core of α-synuclein from invisible crystals. Nature. PMID 26352473 DOI: 10.1038/Nature15368 |
0.342 |
|
| 2015 |
Lai YT, Jiang L, Chen W, Yeates TO. On the predictability of the orientation of protein domains joined by a spanning alpha-helical linker. Protein Engineering, Design & Selection : Peds. PMID 26243886 DOI: 10.1093/Protein/Gzv035 |
0.36 |
|
| 2015 |
Hayden EY, Yamin G, Beroukhim S, Chen B, Kibalchenko M, Jiang L, Ho L, Wang J, Pasinetti GM, Teplow DB. Inhibiting amyloid β-protein assembly: Size-activity relationships among grape seed-derived polyphenols. Journal of Neurochemistry. PMID 26228682 DOI: 10.1111/Jnc.13270 |
0.316 |
|
| 2014 |
Gu L, Liu C, Stroud JC, Ngo S, Jiang L, Guo Z. Antiparallel triple-strand architecture for prefibrillar Aβ42 oligomers. The Journal of Biological Chemistry. 289: 27300-13. PMID 25118290 DOI: 10.1074/Jbc.M114.569004 |
0.357 |
|
| 2013 |
Jiang L, Eisenberg D. Structure-Based Approaches to Amyloid Inhibitors Biophysical Journal. 104: 36a. DOI: 10.1016/J.Bpj.2012.11.236 |
0.337 |
|
| 2012 |
Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proceedings of the National Academy of Sciences of the United States of America. 109: 20913-8. PMID 23213214 DOI: 10.1073/Pnas.1218792109 |
0.348 |
|
| 2012 |
Althoff EA, Wang L, Jiang L, Giger L, Lassila JK, Wang Z, Smith M, Hari S, Kast P, Herschlag D, Hilvert D, Baker D. Robust design and optimization of retroaldol enzymes. Protein Science : a Publication of the Protein Society. 21: 717-26. PMID 22407837 DOI: 10.1002/Pro.2059 |
0.798 |
|
| 2012 |
Wang L, Althoff EA, Bolduc J, Jiang L, Moody J, Lassila JK, Giger L, Hilvert D, Stoddard B, Baker D. Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. Journal of Molecular Biology. 415: 615-25. PMID 22075445 DOI: 10.1016/J.Jmb.2011.10.043 |
0.787 |
|
| 2011 |
Landau M, Sawaya MR, Faull KF, Laganowsky A, Jiang L, Sievers SA, Liu J, Barrio JR, Eisenberg D. Towards a pharmacophore for amyloid. Plos Biology. 9: e1001080. PMID 21695112 DOI: 10.1371/Journal.Pbio.1001080 |
0.331 |
|
| 2011 |
Sievers SA, Karanicolas J, Chang HW, Zhao A, Jiang L, Zirafi O, Stevens JT, Münch J, Baker D, Eisenberg D. Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature. 475: 96-100. PMID 21677644 DOI: 10.1038/Nature10154 |
0.697 |
|
| 2008 |
Röthlisberger D, Khersonsky O, Wollacott AM, Jiang L, DeChancie J, Betker J, Gallaher JL, Althoff EA, Zanghellini A, Dym O, Albeck S, Houk KN, Tawfik DS, Baker D. Kemp elimination catalysts by computational enzyme design. Nature. 453: 190-5. PMID 18354394 DOI: 10.1038/Nature06879 |
0.718 |
|
| 2008 |
Jiang L, Althoff EA, Clemente FR, Doyle L, Röthlisberger D, Zanghellini A, Gallaher JL, Betker JL, Tanaka F, Barbas CF, Hilvert D, Houk KN, Stoddard BL, Baker D. De novo computational design of retro-aldol enzymes. Science (New York, N.Y.). 319: 1387-91. PMID 18323453 DOI: 10.1126/Science.1152692 |
0.762 |
|
| 2006 |
Zanghellini A, Jiang L, Wollacott AM, Cheng G, Meiler J, Althoff EA, Röthlisberger D, Baker D. New algorithms and an in silico benchmark for computational enzyme design. Protein Science : a Publication of the Protein Society. 15: 2785-94. PMID 17132862 DOI: 10.1110/Ps.062353106 |
0.71 |
|
| 2005 |
Jiang L, Kuhlman B, Kortemme T, Baker D. A "solvated rotamer" approach to modeling water-mediated hydrogen bonds at protein-protein interfaces. Proteins. 58: 893-904. PMID 15651050 DOI: 10.1002/Prot.20347 |
0.703 |
|
| 2003 |
Liu Z, Jiang L, Gao Y, Liang S, Chen H, Han Y, Lai L. Beyond the rotamer library: genetic algorithm combined with the disturbing mutation process for upbuilding protein side-chains. Proteins. 50: 49-62. PMID 12471599 DOI: 10.1002/Prot.10253 |
0.545 |
|
| 2002 |
Jiang L, Lai L. CH...O hydrogen bonds at protein-protein interfaces. The Journal of Biological Chemistry. 277: 37732-40. PMID 12119293 DOI: 10.1074/Jbc.M204514200 |
0.495 |
|
| 2002 |
Jiang L, Gao Y, Mao F, Liu Z, Lai L. Potential of mean force for protein-protein interaction studies. Proteins. 46: 190-6. PMID 11807947 DOI: 10.1002/Prot.10031 |
0.519 |
|
| 2000 |
Liang S, Xiao L, Mao F, Jiang L, Han Y, Lai L. Grafting of protein-protein binding sites Chinese Science Bulletin. 45: 1707-1712. DOI: 10.1007/Bf02898992 |
0.535 |
|
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