| Year |
Citation |
Score |
| 2020 |
Kelly L, Seifi M, Ma R, Mitchell SJ, Rudolph U, Viola KL, Klein WL, Lambert JJ, Swinny JD. Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability. Neuropathology and Applied Neurobiology. PMID 33119191 DOI: 10.1111/nan.12674 |
0.301 |
|
| 2020 |
Welikovitch LA, Do Carmo S, Maglóczky Z, Malcolm JC, Lőke J, Klein WL, Freund T, Cuello AC. Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain. Proceedings of the National Academy of Sciences of the United States of America. PMID 32144141 DOI: 10.1073/pnas.1914593117 |
0.349 |
|
| 2018 |
Xie Z, Shapiro LP, Cahill ME, Russell TA, Lacor PN, Klein WL, Penzes P. Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers. The European Journal of Neuroscience. PMID 30565792 DOI: 10.1111/Ejn.14311 |
0.341 |
|
| 2018 |
Cline EN, Das A, Bicca MA, Mohammad SN, Schachner LF, Kamel JM, DiNunno N, Weng A, Paschall JD, Lo Bu R, Khan FM, Rollins MG, Ives AN, Shekhawat G, Nunes-Tavares N, ... ... Klein WL, et al. A Novel Crosslinking Protocol Stabilizes Amyloid β Oligomers Capable of Inducing Alzheimer's-Associated Pathologies. Journal of Neurochemistry. PMID 30565253 DOI: 10.1111/Jnc.14647 |
0.309 |
|
| 2018 |
Cline EN, Bicca MA, Viola KL, Klein WL. The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade. Journal of Alzheimer's Disease : Jad. PMID 29843241 DOI: 10.3233/JAD-179941 |
0.327 |
|
| 2018 |
Batista AF, Forny-Germano L, Clarke JR, Lyra E Silva NM, Brito-Moreira J, Boehnke SE, Winterborn A, Coe BC, Lablans A, Vital JF, Marques SA, Martinez AMB, Gralle M, Holscher C, Klein WL, et al. The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease. The Journal of Pathology. PMID 29435980 DOI: 10.1002/Path.5056 |
0.306 |
|
| 2017 |
Sebollela A, Cline EN, Popova I, Luo K, Sun X, Ahn J, Barcelos MA, Bezerra VN, Lyra E Silva NM, Patel J, Pinheiro NR, Qin LA, Kamel JM, Weng A, DiNunno N, ... ... Klein WL, et al. A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers. Journal of Neurochemistry. PMID 28670737 DOI: 10.1111/Jnc.14118 |
0.333 |
|
| 2017 |
Haure-Mirande JV, Audrain M, Fanutza T, Kim SH, Klein WL, Glabe C, Readhead B, Dudley JT, Blitzer RD, Wang M, Zhang B, Schadt EE, Gandy S, Ehrlich ME. Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology. Acta Neuropathologica. PMID 28612290 DOI: 10.1007/S00401-017-1737-3 |
0.302 |
|
| 2017 |
Yin J, Zhao F, Chojnacki JE, Fulp J, Klein WL, Zhang S, Zhu X. NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer's Disease. Molecular Neurobiology. PMID 28255908 DOI: 10.1007/s12035-017-0467-9 |
0.301 |
|
| 2016 |
Savioz A, Giannakopoulos P, Herrmann FR, Klein WL, Kövari E, Bouras C, Giacobini E. A Study of Aβ Oligomers in the Temporal Cortex and Cerebellum of Patients with Neuropathologically Confirmed Alzheimer's Disease Compared to Aged Controls. Neuro-Degenerative Diseases. 16: 398-406. PMID 27400224 DOI: 10.1159/000446283 |
0.311 |
|
| 2016 |
Knight EM, Kim SH, Kottwitz JC, Hatami A, Albay R, Suzuki A, Lublin A, Alberini CM, Klein WL, Szabo P, Relkin NR, Ehrlich M, Glabe CG, Gandy S, Steele JW. Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes. Neurology® Neuroimmunology & Neuroinflammation. 3: e237. PMID 27218118 DOI: 10.1212/Nxi.0000000000000237 |
0.305 |
|
| 2015 |
Viola KL, Klein WL. Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis. Acta Neuropathologica. 129: 183-206. PMID 25604547 DOI: 10.1007/s00401-015-1386-3 |
0.374 |
|
| 2014 |
Forny-Germano L, Lyra e Silva NM, Batista AF, Brito-Moreira J, Gralle M, Boehnke SE, Coe BC, Lablans A, Marques SA, Martinez AM, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 13629-43. PMID 25297091 DOI: 10.1523/Jneurosci.1353-14.2014 |
0.333 |
|
| 2014 |
Blair JA, Siedlak SL, Wolfram JA, Nunomura A, Castellani RJ, Ferreira ST, Klein WL, Wang Y, Casadesus G, Smith MA, Perry G, Zhu X, Lee HG. Accumulation of intraneuronal amyloid-β is common in normal brain. Current Alzheimer Research. 11: 317-24. PMID 24597504 DOI: 10.2174/1567205011666140302200902 |
0.317 |
|
| 2013 |
Kam TI, Song S, Gwon Y, Park H, Yan JJ, Im I, Choi JW, Choi TY, Kim J, Song DK, Takai T, Kim YC, Kim KS, Choi SY, Choi S, ... Klein WL, et al. FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease. The Journal of Clinical Investigation. 123: 2791-802. PMID 23921129 DOI: 10.1172/Jci66827 |
0.352 |
|
| 2013 |
Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, ... ... Klein WL, et al. Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. Cell Stem Cell. 12: 487-96. PMID 23434393 DOI: 10.1016/J.Stem.2013.01.009 |
0.304 |
|
| 2013 |
Klein WL. Synaptotoxic amyloid-β oligomers: a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease? Journal of Alzheimer's Disease : Jad. 33: S49-65. PMID 22785404 DOI: 10.3233/JAD-2012-129039 |
0.337 |
|
| 2012 |
Nunes-Tavares N, Santos LE, Stutz B, Brito-Moreira J, Klein WL, Ferreira ST, de Mello FG. Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-β peptide oligomers. The Journal of Biological Chemistry. 287: 19377-85. PMID 22505713 DOI: 10.1074/Jbc.M111.321448 |
0.3 |
|
| 2012 |
Ferretti MT, Bruno MA, Ducatenzeiler A, Klein WL, Cuello AC. Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease. Neurobiology of Aging. 33: 1329-42. PMID 21414686 DOI: 10.1016/J.Neurobiolaging.2011.01.007 |
0.302 |
|
| 2011 |
Ferreira ST, Klein WL. The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease. Neurobiology of Learning and Memory. 96: 529-43. PMID 21914486 DOI: 10.1016/J.Nlm.2011.08.003 |
0.306 |
|
| 2011 |
Ferretti MT, Partridge V, Leon WC, Canneva F, Allard S, Arvanitis DN, Vercauteren F, Houle D, Ducatenzeiler A, Klein WL, Glabe CG, Szyf M, Cuello AC. Transgenic mice as a model of pre-clinical Alzheimer's disease. Current Alzheimer Research. 8: 4-23. PMID 21143159 DOI: 10.2174/156720511794604561 |
0.335 |
|
| 2010 |
Krafft GA, Klein WL. ADDLs and the signaling web that leads to Alzheimer's disease. Neuropharmacology. 59: 230-42. PMID 20650286 DOI: 10.1016/J.Neuropharm.2010.07.012 |
0.334 |
|
| 2010 |
Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, et al. A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4845-56. PMID 20371804 DOI: 10.1523/JNEUROSCI.5825-09.2010 |
0.355 |
|
| 2010 |
Leon WC, Canneva F, Partridge V, Allard S, Ferretti MT, DeWilde A, Vercauteren F, Atifeh R, Ducatenzeiler A, Klein W, Szyf M, Alhonen L, Cuello AC. A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment. Journal of Alzheimer's Disease : Jad. 20: 113-26. PMID 20164597 DOI: 10.3233/Jad-2010-1349 |
0.304 |
|
| 2009 |
Tchantchou F, Lacor PN, Cao Z, Lao L, Hou Y, Cui C, Klein WL, Luo Y. Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons. Journal of Alzheimer's Disease : Jad. 18: 787-98. PMID 19661619 DOI: 10.3233/JAD-2009-1189 |
0.334 |
|
| 2009 |
Pitt J, Roth W, Lacor P, Smith AB, Blankenship M, Velasco P, De Felice F, Breslin P, Klein WL. Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal. Toxicology and Applied Pharmacology. 240: 189-97. PMID 19631677 DOI: 10.1016/J.Taap.2009.07.018 |
0.334 |
|
| 2009 |
Kiyota T, Yamamoto M, Xiong H, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction. Plos One. 4: e6197. PMID 19593388 DOI: 10.1371/Journal.Pone.0006197 |
0.327 |
|
| 2009 |
Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 803-9. PMID 19277012 DOI: 10.1038/Mt.2009.44 |
0.328 |
|
| 2009 |
Lambert MP, Velasco PT, Viola KL, Klein WL. Targeting generation of antibodies specific to conformational epitopes of amyloid beta-derived neurotoxins. Cns & Neurological Disorders Drug Targets. 8: 65-81. PMID 19275637 DOI: 10.2174/187152709787601876 |
0.327 |
|
| 2009 |
Wang XP, Zhang JH, Wang YJ, Feng Y, Zhang X, Sun XX, Li JL, Du XT, Lambert MP, Yang SG, Zhao M, Klein WL, Liu RT. Conformation-dependent single-chain variable fragment antibodies specifically recognize beta-amyloid oligomers. Febs Letters. 583: 579-84. PMID 19162022 DOI: 10.1016/j.febslet.2008.12.064 |
0.312 |
|
| 2008 |
Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, ... ... Klein WL, et al. Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Research. 1216: 92-103. PMID 18486110 DOI: 10.1016/J.Brainres.2008.03.079 |
0.305 |
|
| 2008 |
Viola KL, Velasco PT, Klein WL. Why Alzheimer's is a disease of memory: the attack on synapses by A beta oligomers (ADDLs). The Journal of Nutrition, Health & Aging. 12: 51S-7S. PMID 18165846 DOI: 10.1007/BF02982587 |
0.318 |
|
| 2008 |
De Felice FG, Wu D, Lambert MP, Fernandez SJ, Velasco PT, Lacor PN, Bigio EH, Jerecic J, Acton PJ, Shughrue PJ, Chen-Dodson E, Kinney GG, Klein WL. Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers. Neurobiology of Aging. 29: 1334-47. PMID 17403556 DOI: 10.1016/J.Neurobiolaging.2007.02.029 |
0.341 |
|
| 2007 |
De Felice FG, Wasilewska-Sampaio AP, Barbosa AC, Gomes FC, Klein WL, Ferreira ST. Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer's disease. Current Alzheimer Research. 4: 263-71. PMID 17627483 DOI: 10.2174/156720507781077287 |
0.334 |
|
| 2007 |
Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL, Klein WL. Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 796-807. PMID 17251419 DOI: 10.1523/JNEUROSCI.3501-06.2007 |
0.331 |
|
| 2007 |
Lambert MP, Velasco PT, Chang L, Viola KL, Fernandez S, Lacor PN, Khuon D, Gong Y, Bigio EH, Shaw P, De Felice FG, Krafft GA, Klein WL. Monoclonal antibodies that target pathological assemblies of Abeta. Journal of Neurochemistry. 100: 23-35. PMID 17116235 DOI: 10.1111/J.1471-4159.2006.04157.X |
0.312 |
|
| 2006 |
Wu Y, Wu Z, Butko P, Christen Y, Lambert MP, Klein WL, Link CD, Luo Y. Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 13102-13. PMID 17167099 DOI: 10.1523/Jneurosci.3448-06.2006 |
0.313 |
|
| 2006 |
Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, Klein WL, LaFerla FM. Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. The Journal of Biological Chemistry. 281: 1599-604. PMID 16282321 DOI: 10.1074/Jbc.M507892200 |
0.321 |
|
| 2004 |
Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10191-200. PMID 15537891 DOI: 10.1523/Jneurosci.3432-04.2004 |
0.372 |
|
| 2004 |
De Felice FG, Vieira MN, Saraiva LM, Figueroa-Villar JD, Garcia-Abreu J, Liu R, Chang L, Klein WL, Ferreira ST. Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1366-72. PMID 15333579 DOI: 10.1096/Fj.04-1764Com |
0.325 |
|
| 2004 |
Klein WL, Stine WB, Teplow DB. Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease. Neurobiology of Aging. 25: 569-80. PMID 15172732 DOI: 10.1016/J.Neurobiolaging.2004.02.010 |
0.316 |
|
| 2003 |
Chang L, Bakhos L, Wang Z, Venton DL, Klein WL. Femtomole immunodetection of synthetic and endogenous amyloid-beta oligomers and its application to Alzheimer's disease drug candidate screening. Journal of Molecular Neuroscience : Mn. 20: 305-13. PMID 14501013 DOI: 10.1385/Jmn:20:3:305 |
0.342 |
|
| 2003 |
Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, Krafft GA, Klein WL. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proceedings of the National Academy of Sciences of the United States of America. 100: 10417-22. PMID 12925731 DOI: 10.1073/Pnas.1834302100 |
0.342 |
|
| 2003 |
Kim HJ, Chae SC, Lee DK, Chromy B, Lee SC, Park YC, Klein WL, Krafft GA, Hong ST. Selective neuronal degeneration induced by soluble oligomeric amyloid beta protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 118-20. PMID 12424218 DOI: 10.1096/Fj.01-0987Fje |
0.353 |
|
| 2002 |
Klein WL. Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets. Neurochemistry International. 41: 345-52. PMID 12176077 DOI: 10.1016/S0197-0186(02)00050-5 |
0.352 |
|
| 2001 |
Lambert MP, Viola KL, Chromy BA, Chang L, Morgan TE, Yu J, Venton DL, Krafft GA, Finch CE, Klein WL. Vaccination with soluble Abeta oligomers generates toxicity-neutralizing antibodies. Journal of Neurochemistry. 79: 595-605. PMID 11701763 DOI: 10.1046/J.1471-4159.2001.00592.X |
0.31 |
|
| 2001 |
Klein WL, Krafft GA, Finch CE. Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum? Trends in Neurosciences. 24: 219-24. PMID 11250006 DOI: 10.1016/S0166-2236(00)01749-5 |
0.339 |
|
| 1998 |
Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, Klein WL. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proceedings of the National Academy of Sciences of the United States of America. 95: 6448-53. PMID 9600986 DOI: 10.1073/Pnas.95.11.6448 |
0.316 |
|
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