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Christopher L. Cioffi, Ph.D. - Publications

Affiliations: 
2000 Rensselaer Polytechnic Institute, Troy, NY, United States 
Area:
Medications to Treat Addictive Disorders
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17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Gallagher CI, Frangos ZJ, Sheipouri D, Shimmon S, Duman MN, Jayakumar S, Cioffi CL, Rawling T, Vandenberg RJ. Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2. Acs Chemical Neuroscience. PMID 37466545 DOI: 10.1021/acschemneuro.3c00167  0.312
2020 Cioffi CL, Muthuraman P, Raja A, Varadi A, Racz B, Petrukhin K. Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities. Journal of Medicinal Chemistry. PMID 32878437 DOI: 10.1021/Acs.Jmedchem.0C00996  0.34
2020 Mostyn SN, Sarker S, Muthuraman P, Raja A, Shimmon S, Rawling T, Cioffi CL, Vandenberg RJ. A photoswitchable ORG25543 congener enables optical control of glycine transporter 2. Acs Chemical Neuroscience. PMID 32191428 DOI: 10.1021/Acschemneuro.9B00655  0.569
2019 Cioffi CL, Racz B, Váradi A, Freeman E, Conlon MP, Chen P, Zhu L, Kitchen DB, Barnes K, Martin W, Pearson P, Johnson G, Blaner WS, Petrukhin K. Design, Synthesis, and Pre-Clinical Efficacy of Novel Non-Retinoid Antagonists of Retinol Binding Protein 4 in the Mouse Model of Hepatic Steatosis. Journal of Medicinal Chemistry. PMID 31079449 DOI: 10.1021/Acs.Jmedchem.9B00352  0.311
2018 Racz B, Varadi A, Kong J, Allikmets R, Pearson PG, Johnson G, Cioffi CL, Petrukhin K. A non-retinoid antagonist of Retinol-Binding Protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle. The Journal of Biological Chemistry. PMID 29871924 DOI: 10.1074/Jbc.Ra118.002062  0.312
2018 Cioffi CL. Glycine transporter-1 inhibitors: a patent review (2011 - 2016). Expert Opinion On Therapeutic Patents. PMID 29338548 DOI: 10.1080/13543776.2018.1429408  0.31
2017 Cioffi CL. Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain. Journal of Medicinal Chemistry. PMID 28876062 DOI: 10.1021/Acs.Jmedchem.7B00956  0.324
2016 Cioffi CL, Liu S, Wolf MA, Guzzo PR, Sadalapure K, Parthasarathy V, Loong DT, Maeng JH, Carulli E, Fang X, Kalesh KA, Matta L, Choo SH, Panduga S, Buckle RN, et al. Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1. Journal of Medicinal Chemistry. PMID 27559615 DOI: 10.1021/Acs.Jmedchem.6B00914  0.344
2016 Sakthivel P, Sharma N, Klahn P, Gereke M, Brude D, Cioffi CL, Guzzo PR. Inhibitors of Glycine Transporter-1: Potential Therapeutics for the Treatment of CNS Disorders. Current Topics in Medicinal Chemistry. PMID 27048272 DOI: 10.2174/1568026616666160405113340  0.362
2015 Cioffi CL, Racz B, Freeman EE, Conlon MP, Chen P, Stafford DG, Schwarz DM, Zhu L, Kitchen DB, Barnes KD, Dobri N, Michelotti E, Cywin CL, Martin WH, Pearson PG, et al. Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease. Journal of Medicinal Chemistry. PMID 26181715 DOI: 10.1021/Acs.Jmedchem.5B00423  0.358
2014 Cioffi CL, Dobri N, Freeman EE, Conlon MP, Chen P, Stafford DG, Schwarz DM, Golden KC, Zhu L, Kitchen DB, Barnes KD, Racz B, Qin Q, Michelotti E, Cywin CL, et al. Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease. Journal of Medicinal Chemistry. 57: 7731-57. PMID 25210858 DOI: 10.1021/Jm5010013  0.366
2013 Cioffi CL, Wolf MA, Guzzo PR, Sadalapure K, Parthasarathy V, Dethe D, Maeng JH, Carulli E, Loong DT, Fang X, Hu M, Gupta P, Chung M, Bai M, Moore N, et al. Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1. Bioorganic & Medicinal Chemistry Letters. 23: 1257-61. PMID 23380375 DOI: 10.1016/J.Bmcl.2013.01.006  0.332
2011 Manning DD, Cioffi CL, Usyatinsky A, Fitzpatrick K, Masih L, Guo C, Zhang Z, Choo SH, Sikkander MI, Ryan KN, Naginskaya J, Hassler C, Dobritsa S, Wierschke JD, Earley WG, et al. Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome. Bioorganic & Medicinal Chemistry Letters. 21: 58-61. PMID 21146988 DOI: 10.1016/J.Bmcl.2010.11.080  0.333
2010 Yang Z, Fairfax DJ, Maeng JH, Masih L, Usyatinsky A, Hassler C, Isaacson S, Fitzpatrick K, DeOrazio RJ, Chen J, Harding JP, Isherwood M, Dobritsa S, Christensen KL, Wierschke JD, ... ... Cioffi C, et al. Discovery of 2-substituted benzoxazole carboxamides as 5-HT3 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 6538-41. PMID 20889341 DOI: 10.1016/J.Bmcl.2010.09.038  0.307
2010 Cioffi CL, Liu S, Wolf MA. Recent Developments in Glycine Transporter-1 Inhibitors Annual Reports in Medicinal Chemistry. 45: 19-35. DOI: 10.1016/S0065-7743(10)45002-2  0.318
2003 Wentland MP, Ye Y, Cioffi CL, Lou R, Zhou Q, Xu G, Duan W, Dehnhardt CM, Sun X, Cohen DJ, Bidlack JM. Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines Journal of Medicinal Chemistry. 46: 838-849. PMID 12593663 DOI: 10.1021/Jm020429W  0.599
2000 Wentland MP, Xu G, Cioffi CL, Ye Y, Duan W, Cohen DJ, Colasurdo AM, Bidlack JM. 8-Aminocyclazocine analogues: Synthesis and structure-activity relationships Bioorganic and Medicinal Chemistry Letters. 10: 183-187. PMID 10673107 DOI: 10.1016/S0960-894X(99)00670-8  0.6
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