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Robert L. Kortum, Ph.D. - Publications

Affiliations: 
2004 University of Nebraska Medical Center, Omaha, NE, United States 
Area:
Molecular Biology, Cell Biology
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Theard PL, Linke AJ, Sealover NE, Daley BR, Yang J, Cox K, Kortum RL. SOS2 modulates the threshold of EGFR signaling to regulate osimertinib efficacy and resistance in lung adenocarcinoma. Molecular Oncology. PMID 38073064 DOI: 10.1002/1878-0261.13564  0.435
2023 Daley BR, Vieira HM, Rao C, Hughes JM, Beckley ZM, Huisman DH, Chatterjee D, Sealover NE, Cox K, Askew JW, Svoboda RA, Fisher KW, Lewis RE, Kortum RL. SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status. Proceedings of the National Academy of Sciences of the United States of America. 120: e2313137120. PMID 37972068 DOI: 10.1073/pnas.2313137120  0.687
2023 Theard PL, Linke AJ, Sealover NE, Daley BR, Yang J, Cox K, Kortum RL. SOS2 regulates the threshold of mutant -dependent oncogenesis. Biorxiv : the Preprint Server For Biology. PMID 37425733 DOI: 10.1101/2023.01.20.524989  0.422
2022 Hebron KE, Wan X, Roth JS, Liewehr DJ, Sealover NE, Frye WJE, Kim A, Stauffer S, Perkins OL, Sun W, Isanogle KA, Robinson CM, James A, Awasthi P, Shankarappa P, ... ... Kortum RL, et al. The combination of trametinib and ganitumab is effective in RAS-mutated PAX-fusion negative rhabdomyosarcoma models. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 36322002 DOI: 10.1158/1078-0432.CCR-22-1646  0.476
2021 Sheffels E, Kortum RL. Breaking Oncogene Addiction: Getting RTK/RAS-Mutated Cancers off the SOS. Journal of Medicinal Chemistry. PMID 33961431 DOI: 10.1021/acs.jmedchem.1c00698  0.381
2021 Sheffels E, Kortum RL. The Role of Wild-Type RAS in Oncogenic RAS Transformation. Genes. 12. PMID 33924994 DOI: 10.3390/genes12050662  0.386
2020 Theard PL, Sheffels E, Sealover NE, Linke AJ, Pratico DJ, Kortum RL. Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer. Elife. 9. PMID 32897190 DOI: 10.7554/eLife.58204  0.308
2019 Terrell EM, Durrant DE, Ritt DA, Sealover NE, Sheffels E, Spencer-Smith R, Esposito D, Zhou Y, Hancock JF, Kortum RL, Morrison DK. Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling. Molecular Cell. PMID 31606273 DOI: 10.1016/j.molcel.2019.09.004  0.444
2019 Sheffels E, Sealover NE, Theard PL, Kortum RL. Anchorage-independent growth conditions reveal a differential SOS2 dependence for transformation and survival in RAS-mutant cancer cells. Small Gtpases. 1-12. PMID 31062644 DOI: 10.1080/21541248.2019.1611168  0.473
2018 Sheffels E, Sealover NE, Wang C, Kim DH, Vazirani IA, Lee E, M Terrell E, Morrison DK, Luo J, Kortum RL. Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation. Science Signaling. 11. PMID 30181243 DOI: 10.1126/scisignal.aar8371  0.578
2017 Neiswender JV, Kortum RL, Bourque C, Kasheta M, Zon L, Morrison DK, Ceol CJ. KIT suppresses BRAFV600E-mutant melanoma by attenuating oncogenic RAS/MAPK signaling. Cancer Research. PMID 28947418 DOI: 10.1158/0008-5472.Can-17-0473  0.526
2017 Guittard G, Gallardo DL, Li W, Melis N, Lui JC, Kortum RL, Shakarishvili NG, Huh S, Baron J, Weigert R, Kramer JA, Samelson LE, Sommers CL. Unexpected Cartilage Phenotype in CD4-Cre-Conditional SOS-Deficient Mice. Frontiers in Immunology. 8: 343. PMID 28386265 DOI: 10.3389/fimmu.2017.00343  0.336
2015 Kortum RL, Morrison DK. Path Forward for RAF Therapies: Inhibition of Monomers and Dimers. Cancer Cell. 28: 279-81. PMID 26373275 DOI: 10.1016/j.ccell.2015.08.006  0.36
2015 Rouquette-Jazdanian AK, Kortum RL, Li W, Merrill RK, Nguyen PH, Samelson LE, Sommers CL. miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways. Plos One. 10: e0131823. PMID 26121028 DOI: 10.1371/Journal.Pone.0131823  0.427
2015 Rodriguez-Peña AB, Gomez-Rodriguez J, Kortum RL, Palmer DC, Yu Z, Guittard GC, Wohlfert EA, Silver PB, Misplon JA, Sommers CL, Feigenbaum L, Epstein SL, Caspi RR, Belkaid Y, Restifo NP, et al. Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules. Gene Therapy. PMID 26018935 DOI: 10.1038/Gt.2015.48  0.409
2015 Guittard G, Kortum RL, Balagopalan L, Çuburu N, Nguyen P, Sommers CL, Samelson LE. Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration. European Journal of Immunology. PMID 25973715 DOI: 10.1002/Eji.201445226  0.503
2014 Kortum RL, Fernandez MR, Costanzo-Garvey DL, Johnson HJ, Fisher KW, Volle DJ, Lewis RE. Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformation. Molecular and Cellular Biology. 34: 3461-72. PMID 25002533 DOI: 10.1128/Mcb.01633-13  0.784
2013 Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, Nguyen PH, Li W, Agarwal I, Akpan IO, Sommers CL, Samelson LE. The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo. Science Signaling. 6: ra99. PMID 24222714 DOI: 10.1126/Scisignal.2004494  0.587
2013 Baltanás FC, Pérez-Andrés M, Ginel-Picardo A, Diaz D, Jimeno D, Liceras-Boillos P, Kortum RL, Samelson LE, Orfao A, Santos E. Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival. Molecular and Cellular Biology. 33: 4562-78. PMID 24043312 DOI: 10.1128/Mcb.01026-13  0.472
2013 Sommers CL, Rouquette-Jazdanian AK, Robles AI, Kortum RL, Merrill RK, Li W, Nath N, Wohlfert E, Sixt KM, Belkaid Y, Samelson LE. miRNA signature of mouse helper T cell hyper-proliferation. Plos One. 8: e66709. PMID 23825558 DOI: 10.1371/Journal.Pone.0066709  0.316
2013 Kortum RL, Rouquette-Jazdanian AK, Samelson LE. Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells. Trends in Immunology. 34: 259-68. PMID 23506953 DOI: 10.1016/J.It.2013.02.004  0.641
2013 Balagopalan L, Barr VA, Kortum RL, Park AK, Samelson LE. Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling. Journal of Immunology (Baltimore, Md. : 1950). 190: 3849-53. PMID 23487428 DOI: 10.4049/Jimmunol.1202760  0.417
2013 Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL. A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice. Journal of Immunology (Baltimore, Md. : 1950). 190: 147-58. PMID 23209318 DOI: 10.4049/Jimmunol.1201458  0.583
2012 Rouquette-Jazdanian AK, Sommers CL, Kortum RL, Morrison DK, Samelson LE. LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation. Molecular Cell. 48: 298-312. PMID 22981863 DOI: 10.1016/J.Molcel.2012.08.011  0.551
2012 Kortum RL, Sommers CL, Pinski JM, Alexander CP, Merrill RK, Li W, Love PE, Samelson LE. Deconstructing Ras signaling in the thymus. Molecular and Cellular Biology. 32: 2748-59. PMID 22586275 DOI: 10.1128/Mcb.00317-12  0.497
2011 Kortum RL, Sommers CL, Alexander CP, Pinski JM, Li W, Grinberg A, Lee J, Love PE, Samelson LE. Targeted Sos1 deletion reveals its critical role in early T-cell development. Proceedings of the National Academy of Sciences of the United States of America. 108: 12407-12. PMID 21746917 DOI: 10.1073/Pnas.1104295108  0.56
2011 Fisher KW, Das B, Kortum RL, Chaika OV, Lewis RE. Kinase suppressor of ras 1 (KSR1) regulates PGC1α and estrogen-related receptor α to promote oncogenic Ras-dependent anchorage-independent growth. Molecular and Cellular Biology. 31: 2453-61. PMID 21518958 DOI: 10.1128/Mcb.05255-11  0.775
2009 Costanzo-Garvey DL, Pfluger PT, Dougherty MK, Stock JL, Boehm M, Chaika O, Fernandez MR, Fisher K, Kortum RL, Hong EG, Jun JY, Ko HJ, Schreiner A, Volle DJ, Treece T, et al. KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. Cell Metabolism. 10: 366-78. PMID 19883615 DOI: 10.1016/J.Cmet.2009.09.010  0.734
2009 Miyaji M, Kortum RL, Surana R, Li W, Woolard KD, Simpson RM, Samelson LE, Sommers CL. Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 14502-7. PMID 19667175 DOI: 10.1073/Pnas.0903894106  0.5
2009 Kortum RL, Samelson LE. Priming the pump: adhesion enhances T cell antigen receptor-induced signaling. Immunity. 30: 3-5. PMID 19144310 DOI: 10.1016/J.Immuni.2008.12.007  0.427
2006 Kortum RL, Johnson HJ, Costanzo DL, Volle DJ, Razidlo GL, Fusello AM, Shaw AS, Lewis RE. The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence. Molecular and Cellular Biology. 26: 2202-14. PMID 16507997 DOI: 10.1128/Mcb.26.6.2202-2214.2006  0.784
2005 Kortum RL, Costanzo DL, Haferbier J, Schreiner SJ, Razidlo GL, Wu MH, Volle DJ, Mori T, Sakaue H, Chaika NV, Chaika OV, Lewis RE. The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis. Molecular and Cellular Biology. 25: 7592-604. PMID 16107706 DOI: 10.1128/Mcb.25.17.7592-7604.2005  0.79
2005 Kim M, Yan Y, Kortum RL, Stoeger SM, Sgagias MK, Lee K, Lewis RE, Cowan KH. Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity. Cancer Research. 65: 3986-92. PMID 15899786 DOI: 10.1158/0008-5472.Can-03-2334  0.738
2004 Razidlo GL, Kortum RL, Haferbier JL, Lewis RE. Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation. The Journal of Biological Chemistry. 279: 47808-14. PMID 15371409 DOI: 10.1074/Jbc.M406395200  0.781
2004 Kortum RL, Lewis RE. The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells. Molecular and Cellular Biology. 24: 4407-16. PMID 15121859 DOI: 10.1128/Mcb.24.10.4407-4416.2004  0.705
2004 Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA. Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. Nature. 427: 256-60. PMID 14724641 DOI: 10.1038/Nature02237  0.783
2002 Nguyen A, Burack WR, Stock JL, Kortum R, Chaika OV, Afkarian M, Muller WJ, Murphy KM, Morrison DK, Lewis RE, McNeish J, Shaw AS. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Molecular and Cellular Biology. 22: 3035-45. PMID 11940661 DOI: 10.1128/Mcb.22.9.3035-3045.2002  0.766
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