| Year |
Citation |
Score |
| 2024 |
Ghazi PC, O'Toole KT, Srinivas Boggaram S, Scherzer MT, Silvis MR, Zhang Y, Bogdan M, Smith BD, Lozano G, Flynn DL, Snyder EL, Kinsey CG, McMahon M. Inhibition of ULK1/2 and KRAS controls tumor growth in preclinical models of lung cancer. Biorxiv : the Preprint Server For Biology. PMID 38370808 DOI: 10.1101/2024.02.06.579200 |
0.386 |
|
| 2023 |
Parkman GL, Turapov T, Kircher DA, Burnett WJ, Stehn CM, O'Toole K, Culver KM, Chadwick AT, Elmer RC, Flaherty R, Stanley KA, Foth M, Lum DH, Judson-Torres RL, Friend JE, ... ... McMahon M, et al. Genetic silencing of AKT induces melanoma cell death via mTOR suppression. Molecular Cancer Therapeutics. PMID 37931033 DOI: 10.1158/1535-7163.MCT-23-0474 |
0.382 |
|
| 2023 |
Yu Y, Dai M, Huang L, Chen W, Yu E, Mendoza A, Michael H, Khanna C, Bosenberg M, McMahon M, Merlino G. PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6. Iscience. 26: 106070. PMID 36824269 DOI: 10.1016/j.isci.2023.106070 |
0.33 |
|
| 2022 |
Vaishnavi A, Juan J, Jacob M, Stehn C, Gardner EE, Scherzer MT, Schuman S, van Veen JE, Murphy B, Hackett CS, Dupuy AJ, Chmura SA, van der Weyden L, Newberg JY, Liu A, ... ... McMahon M, et al. Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis. Cancer Research. PMID 36112789 DOI: 10.1158/0008-5472.CAN-21-3214 |
0.344 |
|
| 2021 |
Parkman GL, Foth M, Kircher DA, Holmen SL, McMahon M. The role of PI3'-lipid signalling in melanoma initiation, progression and maintenance. Experimental Dermatology. 31: 43-56. PMID 34717019 DOI: 10.1111/exd.14489 |
0.334 |
|
| 2021 |
Foth M, McMahon M. Autophagy Inhibition in BRAF-Driven Cancers. Cancers. 13. PMID 34298710 DOI: 10.3390/cancers13143498 |
0.396 |
|
| 2020 |
Truong A, Yoo JH, Scherzer M, Sanchez JMS, Dale KJ, Kinsey CG, Richards JR, Shin D, Ghazi P, Onken MD, Blumer KJ, Odelberg SJ, McMahon M. Chloroquine sensitizes GNAQ/11-mutated melanoma to MEK1/2 inhibition. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32933997 DOI: 10.1158/1078-0432.Ccr-20-1675 |
0.449 |
|
| 2020 |
Vaishnavi A, Scherzer MT, Kinsey CG, Parkman GL, Truong A, Ghazi P, Schuman S, Battistone B, Garrido-Laguna I, McMahon M. Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer. Cell Reports. 32: 107994. PMID 32755586 DOI: 10.1016/J.Celrep.2020.107994 |
0.501 |
|
| 2020 |
Foth M, Parkman G, Battistone B, McMahon M. RAC1 mutation is not a predictive biomarker for PI3'-kinase- selective pathway-targeted therapy. Pigment Cell & Melanoma Research. PMID 32406574 DOI: 10.1111/Pcmr.12889 |
0.511 |
|
| 2020 |
Vaishnavi A, Scherzer MT, Kinsey C, Garrido-Laguna I, McMahon M. Abstract 3769: Combined TRKA and MEK1/2 Inhibition Forestalls the Onset of Acquired Resistance in a New Preclinical Model of NTRK1+ Pancreatic Cancer Immunology. 80: 3769-3769. DOI: 10.1158/1538-7445.Am2020-3769 |
0.515 |
|
| 2020 |
Kircher DA, Trombetti KA, Silvis MR, Parkman GL, Fischer GM, Angel SN, Stehn CM, Strain SC, Grossmann AH, Duffy KL, McMahon M, Davies MA, Mendoza MC, VanBrocklin MW, Holmen SL. Abstract 2736: AKT1E17Kactivates focal adhesion kinase and promotes melanoma brain metastasis Tumor Biology. DOI: 10.1158/1538-7445.Am2020-2736 |
0.339 |
|
| 2020 |
Foth M, Kinsey C, Schuman S, Battistone B, Sanchez EC, Kircher D, Welm B, Holmen S, McMahon M. Abstract 1225: Co-inhibition of autophagy and MAPK signaling in RAS-driven cancers Cancer Research. 80: 1225-1225. DOI: 10.1158/1538-7445.Am2020-1225 |
0.437 |
|
| 2020 |
Dale KJ, McMahon M. Abstract 1088: Elucidating the regulation of delayed-early gene targets of sustained MAPK signaling Tumor Biology. DOI: 10.1158/1538-7445.Am2020-1088 |
0.325 |
|
| 2020 |
Truong A, Onken M, Blumer K, McMahon M. 656 GDP/GTP exchange inhibitor, FR900359, synergizes with chloroquine in GNAQ/11-mutant melanoma Journal of Investigative Dermatology. 140. DOI: 10.1016/J.Jid.2020.03.668 |
0.333 |
|
| 2019 |
van Veen JE, Scherzer M, Boshuizen J, Chu M, Liu A, Landman A, Green S, Trejo C, McMahon M. Mutationally-activated PI3'-kinase-α promotes de-differentiation of lung tumors initiated by the BRAF oncoprotein kinase. Elife. 8. PMID 31452510 DOI: 10.7554/Elife.43668 |
0.803 |
|
| 2019 |
Kircher DA, Trombetti KA, Silvis MR, Parkman GL, Fischer GM, Angel SN, Stehn CM, Strain SC, Grossmann AH, Duffy KL, Boucher KM, McMahon M, Davies MA, Mendoza MC, VanBrocklin MW, et al. AKT1E17K activates focal adhesion kinase and promotes melanoma brain metastasis. Molecular Cancer Research : McR. PMID 31138602 DOI: 10.1158/1541-7786.Mcr-18-1372 |
0.479 |
|
| 2019 |
Kinsey CG, Camolotto SA, Boespflug AM, Gullien KP, Foth M, Truong A, Schuman SS, Shea JE, Seipp MT, Yap JT, Burrell LD, Lum DH, Whisenant JR, Gilcrease GW, Cavalieri CC, ... ... McMahon M, et al. Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers. Nature Medicine. PMID 30833748 DOI: 10.1038/S41591-019-0367-9 |
0.479 |
|
| 2019 |
Veen JEv, Scherzer M, Boshuizen J, Chu M, Liu A, Landman A, Green S, Trejo C, McMahon M. Author response: Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase Elife. DOI: 10.7554/Elife.43668.050 |
0.777 |
|
| 2019 |
Kinsey C, Silva D, Silvis M, Schuman S, Affolter K, McMahon M. Abstract C30: Myc amplification is a negative biomarker and a resistance mechanism to trametinib/HCQ treatment, but can be overcome by combined palbociclib/HCQ treatment Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-C30 |
0.433 |
|
| 2019 |
Kinsey CG, Camolotto SA, Boespflug AM, Guillen KP, Foth M, Truong A, Schuman SS, Shea JE, Seipp MT, Yap JT, Burrell LD, Lum DH, Whisenant JR, Gilcrease GW, Cavalieri CC, ... ... McMahon M, et al. Abstract 2183: Protective autophagy elicited by RAF®MEK®ERK inhibition suggests a treatment strategy for pancreatic cancer Cancer Research. 79: 2183-2183. DOI: 10.1158/1538-7445.Am2019-2183 |
0.412 |
|
| 2019 |
Truong A, Kinsey C, Foth M, Scherzer M, Sanchez J, McMahon M. 816 Autophagy inhibition sensitizes targeted therapy-resistant melanoma to MEK1/2 inhibitors Journal of Investigative Dermatology. 139. DOI: 10.1016/J.Jid.2019.03.892 |
0.315 |
|
| 2018 |
Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, ... ... McMahon M, et al. Proceedings of the fifth international RASopathies symposium: When development and cancer intersect. American Journal of Medical Genetics. Part A. e40632. PMID 30302932 DOI: 10.1002/Ajmg.A.40632 |
0.437 |
|
| 2018 |
Kinsey C, Guillen K, Camolotto S, Boespflug A, Shea J, Seipp M, Scaife C, McMahon M. Abstract LB-254: Combined inhibition of MEK and autophagy promotes regression of pancreatic cancer Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Lb-254 |
0.469 |
|
| 2017 |
Silva JM, Deuker MM, Baguley BC, McMahon M. PIK3CA-Mutated Melanoma Cells Rely on Cooperative Signaling through mTORC1/2 for Sustained Proliferation. Pigment Cell & Melanoma Research. PMID 28233937 DOI: 10.1111/Pcmr.12586 |
0.497 |
|
| 2017 |
Sakamoto N, Feng Y, Stolfi C, Kurosu Y, Green M, Lin J, Green M, Sentani K, Yasui W, McMahon M, Hardiman KM, Spence JR, Horita N, Greenson JK, Kuick R, et al. BRAF(V600E) cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis. Elife. 6. PMID 28072391 DOI: 10.7554/Elife.20331 |
0.358 |
|
| 2016 |
Grossauer S, Koeck K, Murphy NE, Meyers ID, Daynac M, Truffaux N, Truong AY, Nicolaides TP, McMahon M, Berger MS, Phillips JJ, James CD, Petritsch CK. Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model. Oncotarget. PMID 27713119 DOI: 10.18632/Oncotarget.12419 |
0.493 |
|
| 2016 |
van Veen JE, Pringle DR, McMahon M. P2A-Fluorophore Tagging of BRAF Tightly Links Expression to Fluorescence In Vivo. Plos One. 11: e0157661. PMID 27348307 DOI: 10.1371/Journal.Pone.0157661 |
0.388 |
|
| 2016 |
Deuker MM, McMahon M. Rational targeting of BRAF and PI3-Kinase signaling for melanoma therapy. Molecular & Cellular Oncology. 3: e1033095. PMID 27314067 DOI: 10.1080/23723556.2015.1033095 |
0.469 |
|
| 2016 |
Kircher D, Cho J, Robinson J, Arave R, Green R, Chen G, Davies M, Grossmann A, VanBrocklin M, McMahon M, Holmen S. Abstract 37: AKT1 activation promotes brain metastasis in a mouse model of melanoma Clinical Cancer Research. 22: 37-37. DOI: 10.1158/1557-3265.Pmsclingen15-37 |
0.397 |
|
| 2016 |
Silva JM, Deuker MM, Baguley BC, McMahon M. Abstract 29: MEK and PI3K signaling cooperate through mTORC1/2 to promote PIK3CA mutant melanoma cell proliferation Cancer Research. 76: 29-29. DOI: 10.1158/1538-7445.Am2016-29 |
0.531 |
|
| 2015 |
Green S, Trejo CL, McMahon M. PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis. Cancer Research. 75: 5378-91. PMID 26567140 DOI: 10.1158/0008-5472.Can-15-1249 |
0.797 |
|
| 2015 |
Cho JH, Robinson JP, Arave RA, Burnett WJ, Kircher DA, Chen G, Davies MA, Grossmann AH, VanBrocklin MW, McMahon M, Holmen SL. AKT1 Activation Promotes Development of Melanoma Metastases. Cell Reports. 13: 898-905. PMID 26565903 DOI: 10.1016/J.Celrep.2015.09.057 |
0.465 |
|
| 2015 |
Shai A, Dankort D, Juan J, Green S, McMahon M. TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells In a Two-Switch Model of Lung Tumorigenesis. Cancer Research. PMID 26001956 DOI: 10.1158/0008-5472.Can-14-3701 |
0.454 |
|
| 2015 |
Mann MB, Black MA, Jones DJ, Ward JM, Yew CC, Newberg JY, Dupuy AJ, Rust AG, Bosenberg MW, McMahon M, Print CG, Copeland NG, Jenkins NA. Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma. Nature Genetics. 47: 486-95. PMID 25848750 DOI: 10.1038/Ng.3275 |
0.393 |
|
| 2015 |
Lin L, Sabnis AJ, Chan E, Olivas V, Cade L, Pazarentzos E, Asthana S, Neel D, Yan JJ, Lu X, Pham L, Wang MM, Karachaliou N, Cao MG, Manzano JL, ... ... McMahon M, et al. The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. Nature Genetics. 47: 250-6. PMID 25665005 DOI: 10.1038/Ng.3218 |
0.443 |
|
| 2015 |
Damsky W, Micevic G, Meeth K, Muthusamy V, Curley DP, Santhanakrishnan M, Erdelyi I, Platt JT, Huang L, Theodosakis N, Zaidi MR, Tighe S, Davies MA, Dankort D, McMahon M, et al. mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation. Cancer Cell. 27: 41-56. PMID 25584893 DOI: 10.1016/J.Ccell.2014.11.014 |
0.411 |
|
| 2015 |
Deuker MM, Marsh Durban V, Phillips WA, McMahon M. PI3'-kinase inhibition forestalls the onset of MEK1/2 inhibitor resistance in BRAF-mutated melanoma. Cancer Discovery. 5: 143-53. PMID 25472943 DOI: 10.1158/2159-8290.Cd-14-0856 |
0.444 |
|
| 2015 |
Deuker MM, Durban VM, Phillips W, McMahon M. Abstract B11: PI3-kinase inhibition forestalls the development of drug resistance in BRAFV600E/PTENNull melanoma Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-B11 |
0.512 |
|
| 2015 |
Green S, McMahon M. Abstract A37: PI3-kinase signaling is rate limiting for KRASG12D-driven lung tumorigenesis but is not required for tumor maintenance Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-A37 |
0.55 |
|
| 2015 |
Silva JM, Deuker MM, Joseph WR, Baguley BC, McMahon M. Abstract A09: Cooperation of the MAPK and PI3K>AKT>mTORC1 signaling pathways is required for PIK3CA mutant melanoma maintenance Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-A09 |
0.485 |
|
| 2015 |
Deuker MM, Marsh-Durban V, Phillips WA, Silva JM, McMahon M. Abstract IA29: PI3′ -kinase inhibition forestalls the onset of MEK1/2 inhibitor resistance in BRAFV600E/PTENNull melanoma Cancer Research. 75. DOI: 10.1158/1538-7445.Mel2014-Ia29 |
0.382 |
|
| 2014 |
Holderfield M, Deuker MM, McCormick F, McMahon M. Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond. Nature Reviews. Cancer. 14: 455-67. PMID 24957944 DOI: 10.1038/Nrc3760 |
0.47 |
|
| 2014 |
Cooper ZA, Juneja VR, Sage PT, Frederick DT, Piris A, Mitra D, Lo JA, Hodi FS, Freeman GJ, Bosenberg MW, McMahon M, Flaherty KT, Fisher DE, Sharpe AH, Wargo JA. Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade. Cancer Immunology Research. 2: 643-54. PMID 24903021 DOI: 10.1158/2326-6066.Cir-13-0215 |
0.394 |
|
| 2014 |
Deuker MM, McMahon M. Cancer biology: Enzyme meets a surprise target. Nature. 510: 225-6. PMID 24847879 DOI: 10.1038/Nature13343 |
0.537 |
|
| 2014 |
Charles RP, Silva J, Iezza G, Phillips WA, McMahon M. Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis. Molecular Cancer Research : McR. 12: 979-86. PMID 24770869 DOI: 10.1158/1541-7786.Mcr-14-0158-T |
0.397 |
|
| 2014 |
Luo X, Mitra D, Sullivan RJ, Wittner BS, Kimura AM, Pan S, Hoang MP, Brannigan BW, Lawrence DP, Flaherty KT, Sequist LV, McMahon M, Bosenberg MW, Stott SL, Ting DT, et al. Isolation and molecular characterization of circulating melanoma cells. Cell Reports. 7: 645-53. PMID 24746818 DOI: 10.1016/J.Celrep.2014.03.039 |
0.374 |
|
| 2014 |
McFadden DG, Vernon A, Santiago PM, Martinez-McFaline R, Bhutkar A, Crowley DM, McMahon M, Sadow PM, Jacks T. p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer. Proceedings of the National Academy of Sciences of the United States of America. 111: E1600-9. PMID 24711431 DOI: 10.1073/Pnas.1404357111 |
0.435 |
|
| 2014 |
Juan J, Muraguchi T, Iezza G, Sears RC, McMahon M. Diminished WNT -> β-catenin -> c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors. Genes & Development. 28: 561-75. PMID 24589553 DOI: 10.1101/Gad.233627.113 |
0.384 |
|
| 2014 |
Silva JM, Bulman C, McMahon M. BRAFV600E cooperates with PI3K signaling, independent of AKT, to regulate melanoma cell proliferation. Molecular Cancer Research : McR. 12: 447-63. PMID 24425783 DOI: 10.1158/1541-7786.Mcr-13-0224-T |
0.497 |
|
| 2014 |
Goodwin AF, Tidyman WE, Jheon AH, Sharir A, Zheng X, Charles C, Fagin JA, McMahon M, Diekwisch TG, Ganss B, Rauen KA, Klein OD. Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation. Human Molecular Genetics. 23: 682-92. PMID 24057668 DOI: 10.1093/Hmg/Ddt455 |
0.451 |
|
| 2014 |
Lerner RG, Ihara Y, Lewis K, Griveau A, Reichhold B, Qu D, McMahon M, Rowitch D, James CD, Petritsch C. Abstract 1944: Divergent effects of BRAF activation in neural stem and progenitor-like glioblastoma cells Cancer Research. 74: 1944-1944. DOI: 10.1158/1538-7445.Am2014-1944 |
0.391 |
|
| 2014 |
Kadkhodaei B, Lerner RG, Sidorov M, Gomez-Lopez S, McMahon M, James D, Petritsch C. SC-14 * ASYMMETRY-DEFECTIVE OLIGODENDROCYTE PROGENITORS AS POTENTIAL CELL-OF-ORIGIN OF HYPERACTIVATED RAF-INDUCED MALIGNANT ASTROCYTOMAS Neuro-Oncology. 16: v200-v200. DOI: 10.1093/Neuonc/Nou275.14 |
0.442 |
|
| 2014 |
Petritsch C, Lerner R, Lewis K, Andor N, Ozawa T, Yoshida Y, McMahon M, Nicolaides T, David James C. STEM- AND PROGENITOR-LIKE CELL CONTRIBUTION TO MALIGNANT ASTROCYTOMA HETEROGENEITY Neuro-Oncology. 16: iii21-iii21. DOI: 10.1093/Neuonc/Nou206.76 |
0.413 |
|
| 2014 |
Deuker M, Durban VM, Phillips W, McMahon M. 304 PI3′-Kinase inhibition forestalls the development of drug resistance in BRAFV600E/PTENNull melanoma European Journal of Cancer. 50: 100. DOI: 10.1016/S0959-8049(14)70430-7 |
0.503 |
|
| 2013 |
Marsh Durban V, Deuker MM, Bosenberg MW, Phillips W, McMahon M. Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma. The Journal of Clinical Investigation. 123: 5104-18. PMID 24200692 DOI: 10.1172/Jci69619 |
0.514 |
|
| 2013 |
Kamata T, Dankort D, Kang J, Giblett S, Pritchard CA, McMahon M, Leavitt AD. Hematopoietic expression of oncogenic BRAF promotes aberrant growth of monocyte-lineage cells resistant to PLX4720. Molecular Cancer Research : McR. 11: 1530-41. PMID 24152792 DOI: 10.1158/1541-7786.Mcr-13-0294 |
0.499 |
|
| 2013 |
Yuan P, Ito K, Perez-Lorenzo R, Del Guzzo C, Lee JH, Shen CH, Bosenberg MW, McMahon M, Cantley LC, Zheng B. Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma. Proceedings of the National Academy of Sciences of the United States of America. 110: 18226-31. PMID 24145418 DOI: 10.1073/Pnas.1317577110 |
0.505 |
|
| 2013 |
Trejo CL, Green S, Marsh V, Collisson EA, Iezza G, Phillips WA, McMahon M. Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression. Cancer Research. 73: 6448-61. PMID 24019382 DOI: 10.1158/0008-5472.Can-13-0681 |
0.784 |
|
| 2013 |
Strohecker AM, Guo JY, Karsli-Uzunbas G, Price SM, Chen GJ, Mathew R, McMahon M, White E. Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. Cancer Discovery. 3: 1272-85. PMID 23965987 DOI: 10.1158/2159-8290.Cd-13-0397 |
0.375 |
|
| 2013 |
Das Thakur M, Salangsang F, Landman AS, Sellers WR, Pryer NK, Levesque MP, Dummer R, McMahon M, Stuart DD. Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance. Nature. 494: 251-5. PMID 23302800 DOI: 10.1038/Nature11814 |
0.305 |
|
| 2013 |
Maertens O, Johnson B, Hollstein P, Frederick DT, Cooper ZA, Messiaen L, Bronson RT, McMahon M, Granter S, Flaherty K, Wargo JA, Marais R, Cichowski K. Elucidating distinct roles for NF1 in melanomagenesis. Cancer Discovery. 3: 338-49. PMID 23171796 DOI: 10.1158/2159-8290.Cd-12-0313 |
0.411 |
|
| 2013 |
Mito JK, Min HD, Ma Y, Carter JE, Brigman BE, Dodd L, Dankort D, McMahon M, Kirsch DG. Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma. The Journal of Pathology. 229: 132-40. PMID 22951975 DOI: 10.1002/Path.4099 |
0.307 |
|
| 2013 |
McMahon M, Thakur MD, Marsh V, Silva J, Landman A, Deuker M, Salangsang F, Pryer N, Phillips W, Levesque M, Dummer R, Bosenberg M, Sellers WR, Stuart D. Abstract SY17-03: Targeting BRAF and PI3′-kinase signaling for therapy of melanoma. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Sy17-03 |
0.492 |
|
| 2013 |
Thakur MD, Fisher R, Salangsang F, Landman A, Sellers W, Pryer N, Levesque MP, Dummer R, Gore M, Larkin J, McMahon M, Stuart D. Abstract LB-144: Modeling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-144 |
0.386 |
|
| 2013 |
Maertens O, Johnson B, Hollstein P, Frederick D, Cooper Z, Messiaen L, Bronson R, McMahon M, Granter S, Flaherty K, Wargo J, Marais R, Cichowski K. Abstract 5201: Elucidating distinct roles for NF1 in melanomagenesis. Cancer Research. 73: 5201-5201. DOI: 10.1158/1538-7445.Am2013-5201 |
0.42 |
|
| 2013 |
Lerner RG, Ihara Y, Reichholf B, Qu D, Sugiarto S, Griveau A, James D, McMahon M, Petritsch C. Abstract 2298: Cell-specific effects of BRafV600E expression disrupt gliogenesis and lead to astrocytoma formation. Cancer Research. 73: 2298-2298. DOI: 10.1158/1538-7445.Am2013-2298 |
0.419 |
|
| 2013 |
Mann MB, Black MA, Ward JM, Bosenberg MW, McMahon M, Print CG, Adams DJ, Copeland NG, Jenkins NA. Abstract 1116: Sleeping Beauty mutagenesis identifies genes and pathways that cooperate with BrafV600E in melanoma initiation and progression. Cancer Research. 73: 1116-1116. DOI: 10.1158/1538-7445.Am2013-1116 |
0.4 |
|
| 2012 |
Andreadi C, Cheung LK, Giblett S, Patel B, Jin H, Mercer K, Kamata T, Lee P, Williams A, McMahon M, Marais R, Pritchard C. The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. Genes & Development. 26: 1945-58. PMID 22892241 DOI: 10.1101/Gad.193458.112 |
0.527 |
|
| 2012 |
Wang J, Kobayashi T, Floc'h N, Kinkade CW, Aytes A, Dankort D, Lefebvre C, Mitrofanova A, Cardiff RD, McMahon M, Califano A, Shen MM, Abate-Shen C. B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer. Cancer Research. 72: 4765-76. PMID 22836754 DOI: 10.1158/0008-5472.Can-12-0820 |
0.455 |
|
| 2012 |
Gysin S, Paquette J, McMahon M. Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. Molecular Cancer Research : McR. 10: 1607-19. PMID 22833572 DOI: 10.1158/1541-7786.Mcr-12-0188 |
0.493 |
|
| 2012 |
Tien AC, Tsai HH, Molofsky AV, McMahon M, Foo LC, Kaul A, Dougherty JD, Heintz N, Gutmann DH, Barres BA, Rowitch DH. Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development (Cambridge, England). 139: 2477-87. PMID 22675209 DOI: 10.1242/Jcs.116657 |
0.319 |
|
| 2012 |
Collisson EA, Trejo CL, Silva JM, Gu S, Korkola JE, Heiser LM, Charles RP, Rabinovich BA, Hann B, Dankort D, Spellman PT, Phillips WA, Gray JW, McMahon M. A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma. Cancer Discovery. 2: 685-93. PMID 22628411 DOI: 10.1158/2159-8290.Cd-11-0347 |
0.785 |
|
| 2012 |
Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proceedings of the National Academy of Sciences of the United States of America. 109: 8710-5. PMID 22586120 DOI: 10.1073/Pnas.1117255109 |
0.442 |
|
| 2012 |
Li CY, Cha W, Luder HU, Charles RP, McMahon M, Mitsiadis TA, Klein OD. E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor. Developmental Biology. 366: 357-66. PMID 22537490 DOI: 10.1016/J.Ydbio.2012.03.012 |
0.315 |
|
| 2012 |
Trejo CL, Juan J, Vicent S, Sweet-Cordero A, McMahon M. MEK1/2 inhibition elicits regression of autochthonous lung tumors induced by KRASG12D or BRAFV600E. Cancer Research. 72: 3048-59. PMID 22511580 DOI: 10.1158/0008-5472.Can-11-3649 |
0.79 |
|
| 2012 |
Thakur MD, Salangsang F, Pryer N, Stuart D, McMahon M. Abstract 5592: Modeling the evolution of resistance to RAF inhibitors in clinically relevant melanoma models Cancer Research. 72: 5592-5592. DOI: 10.1158/1538-7445.Am2012-5592 |
0.41 |
|
| 2012 |
Thakur MD, Salangsang F, Pryer N, McMahon M, Stuart D. Abstract A33: Modeling clinical resistance to RAF inhibitors in an in vivo melanoma model provides insights into prevention of resistance Clinical Cancer Research. 18. DOI: 10.1158/1078-0432.Mechres-A33 |
0.383 |
|
| 2011 |
Damsky WE, Curley DP, Santhanakrishnan M, Rosenbaum LE, Platt JT, Gould Rothberg BE, Taketo MM, Dankort D, Rimm DL, McMahon M, Bosenberg M. β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Cancer Cell. 20: 741-54. PMID 22172720 DOI: 10.1016/J.Ccr.2011.10.030 |
0.404 |
|
| 2011 |
Tang N, Marshall WF, McMahon M, Metzger RJ, Martin GR. Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape. Science (New York, N.Y.). 333: 342-5. PMID 21764747 DOI: 10.1126/Science.1204831 |
0.44 |
|
| 2011 |
Charles RP, Iezza G, Amendola E, Dankort D, McMahon M. Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse. Cancer Research. 71: 3863-71. PMID 21512141 DOI: 10.1158/0008-5472.Can-10-4463 |
0.358 |
|
| 2011 |
Rauen KA, Banerjee A, Bishop WR, Lauchle JO, McCormick F, McMahon M, Melese T, Munster PN, Nadaf S, Packer RJ, Sebolt-Leopold J, Viskochil DH. Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. 157: 136-46. PMID 21495172 DOI: 10.1002/Ajmg.C.30294 |
0.418 |
|
| 2011 |
McMahon M. Parsing out the complexity of RAF inhibitor resistance. Pigment Cell & Melanoma Research. 24: 361-5. PMID 21392366 DOI: 10.1111/J.1755-148X.2010.00824.X |
0.407 |
|
| 2011 |
Thakur MD, Salangsang F, Pryer N, McMahon M, Stuart D. Abstract B131: Modeling the evolution of resistance to RAF inhibitors in clinically relevant melanoma models. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-B131 |
0.406 |
|
| 2010 |
McMahon M. RAF translocations expand cancer targets. Nature Medicine. 16: 749-50. PMID 20613748 DOI: 10.1038/Nm0710-749 |
0.324 |
|
| 2010 |
Amin DN, Sergina N, Ahuja D, McMahon M, Blair JA, Wang D, Hann B, Koch KM, Shokat KM, Moasser MM. Resiliency and vulnerability in the HER2-HER3 tumorigenic driver. Science Translational Medicine. 2: 16ra7. PMID 20371474 DOI: 10.1126/Scitranslmed.3000389 |
0.503 |
|
| 2010 |
Held MA, Curley DP, Dankort D, McMahon M, Muthusamy V, Bosenberg MW. Characterization of melanoma cells capable of propagating tumors from a single cell. Cancer Research. 70: 388-97. PMID 20048081 DOI: 10.1158/0008-5472.Can-09-2153 |
0.376 |
|
| 2010 |
Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, ... ... McMahon M, et al. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. American Journal of Medical Genetics. Part A. 152: 4-24. PMID 20014119 DOI: 10.1002/Ajmg.A.33183 |
0.304 |
|
| 2010 |
Mito JK, Ferrer JM, Brigman BE, Lee C, Dodd RD, Eward WC, Marshall LF, Dankort D, McMahon M, Kim Y, Lee WD, Griffith LG, Bawendi MG, Kirsch DG. Abstract 4316: A novel wide field-of-view imaging device for real-time, intra-operative tumor bed assessment Cancer Research. 70: 4316-4316. DOI: 10.1158/1538-7445.Am10-4316 |
0.346 |
|
| 2010 |
Amin DN, Sergina N, Ahuja D, McMahon M, Wang D, Hann B, Shokat K, Moasser MM. Abstract 1653: Highly effective treatment of HER2-amplified breast cancers through the complete inactivation of the HER2-HER3 tumorigenic driver Cancer Research. 70: 1653-1653. DOI: 10.1158/1538-7445.Am10-1653 |
0.425 |
|
| 2009 |
Krueger F, Madeja Z, Hemberger M, McMahon M, Cook SJ, Gaunt SJ. Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway. Cellular Signalling. 21: 1846-56. PMID 19686845 DOI: 10.1016/J.Cellsig.2009.07.020 |
0.5 |
|
| 2009 |
Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky WE, You MJ, DePinho RA, McMahon M, Bosenberg M. Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nature Genetics. 41: 544-52. PMID 19282848 DOI: 10.1038/Ng.356 |
0.403 |
|
| 2009 |
Klarlund JK, Cherniack AD, McMahon M, Czech MP. P-63: Activation of the Raf/Mitogen-activated protein kinase pathway is not sufficient for disassembly of Grb2/Sos or p21ras desensitization Experimental and Clinical Endocrinology & Diabetes. 104: 128-129. DOI: 10.1055/S-0029-1211606 |
0.411 |
|
| 2008 |
Cartlidge RA, Thomas GR, Cagnol S, Jong KA, Molton SA, Finch AJ, McMahon M. Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival. Pigment Cell & Melanoma Research. 21: 534-44. PMID 18715233 DOI: 10.1111/J.1755-148X.2008.00491.X |
0.491 |
|
| 2008 |
McCubrey JA, Abrams SL, Ligresti G, Misaghian N, Wong EW, Steelman LS, Bäsecke J, Troppmair J, Libra M, Nicoletti F, Molton S, McMahon M, Evangelisti C, Martelli AM. Involvement of p53 and Raf/MEK/ERK pathways in hematopoietic drug resistance. Leukemia. 22: 2080-90. PMID 18685611 DOI: 10.1038/Leu.2008.207 |
0.317 |
|
| 2007 |
Dankort D, Filenova E, Collado M, Serrano M, Jones K, McMahon M. A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes & Development. 21: 379-84. PMID 17299132 DOI: 10.1101/Gad.1516407 |
0.502 |
|
| 2007 |
Liu J, Suresh Kumar KG, Yu D, Molton SA, McMahon M, Herlyn M, Thomas-Tikhonenko A, Fuchs SY. Oncogenic BRAF regulates β-Trcp expression and NF-κB activity in human melanoma cells Oncogene. 26: 1954-1958. PMID 17001349 DOI: 10.1038/Sj.Onc.1209994 |
0.458 |
|
| 2006 |
Banerjee A, Gugasyan R, McMahon M, Gerondakis S. Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 3274-9. PMID 16484370 DOI: 10.1073/Pnas.0511113103 |
0.396 |
|
| 2005 |
Brandts CH, Sargin B, Rode M, Biermann C, Lindtner B, Schwäble J, Buerger H, Müller-Tidow C, Choudhary C, McMahon M, Berdel WE, Serve H. Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation. Cancer Research. 65: 9643-50. PMID 16266983 DOI: 10.1158/0008-5472.Can-05-0422 |
0.482 |
|
| 2005 |
Shelton JG, Steelman LS, Abrams SL, Bertrand FE, Franklin RA, McMahon M, McCubrey JA. The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it? Expert Opinion On Therapeutic Targets. 9: 1009-30. PMID 16185155 DOI: 10.1517/14728222.9.5.1009 |
0.44 |
|
| 2005 |
Gysin S, Lee SH, Dean NM, McMahon M. Pharmacologic inhibition of RAF-->MEK-->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1. Cancer Research. 65: 4870-80. PMID 15930308 DOI: 10.1158/0008-5472.Can-04-2848 |
0.495 |
|
| 2005 |
Gysin S, Rickert P, Kastury K, McMahon M. Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines. Genes, Chromosomes & Cancer. 44: 37-51. PMID 15929091 DOI: 10.1002/Gcc.20216 |
0.388 |
|
| 2005 |
Shelton JG, Steelman LS, Abrams SL, White ER, Akula SM, Franklin RA, Bertrand FE, McMahon M, McCubrey JA. Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines. Cell Cycle (Georgetown, Tex.). 4: 822-30. PMID 15917660 DOI: 10.4161/Cc.4.6.1724 |
0.447 |
|
| 2005 |
Sreeramaneni R, Chaudhry A, McMahon M, Sherr CJ, Inoue K. Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor. Molecular and Cellular Biology. 25: 220-32. PMID 15601844 DOI: 10.1128/Mcb.25.1.220-232.2005 |
0.408 |
|
| 2005 |
Libra M, Mazzarino MC, De Re V, Steelman LS, Abrams SL, Bertrand FE, Shelton JG, Molton S, McMahon M, McCubrey JA. Role of BRAF Mutations in Hematopoietic Malignancies and the Induction of Cytokine-Independence-Synergy with PI3K/Akt Pathway. Blood. 106: 4291-4291. DOI: 10.1182/Blood.V106.11.4291.4291 |
0.463 |
|
| 2004 |
Mirza AM, Gysin S, Malek N, Nakayama K, Roberts JM, McMahon M. Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT. Molecular and Cellular Biology. 24: 10868-81. PMID 15572689 DOI: 10.1128/Mcb.24.24.10868-10881.2004 |
0.486 |
|
| 2004 |
McCubrey JA, Shelton JG, Steelman LS, Franklin RA, Sreevalsan T, McMahon M. Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells. Oncogene. 23: 7810-20. PMID 15361836 DOI: 10.1038/Sj.Onc.1208055 |
0.423 |
|
| 2004 |
Silletti S, Yebra M, Perez B, Cirulli V, McMahon M, Montgomery AM. Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. The Journal of Biological Chemistry. 279: 28880-8. PMID 15128735 DOI: 10.1074/Jbc.M404075200 |
0.369 |
|
| 2004 |
Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG. Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. The Journal of Clinical Investigation. 113: 539-50. PMID 14966563 DOI: 10.1172/Jci18829 |
0.324 |
|
| 2004 |
Shelton JG, Steelman LS, McMahon M, McCubrey JA. Effects of EGF-R on Transcription Factor Activation in Hematopoietic Cells: EGF-R Activates Multiple Transcription Factors Which Induce Proliferation in the Absence of Autocrine Cytokines. Blood. 104: 4185-4185. DOI: 10.1182/Blood.V104.11.4185.4185 |
0.442 |
|
| 2004 |
Brandts CH, Sargin B, Rode M, Biermann C, Lindtner B, Schwable J, Buerger H, Muller-Tidow C, Choudhary C, McMahon M, Berdel WE, Serve HL. Constitutive Activation of Akt and mTOR by Flt3 Internal Tandem Duplications Mediates Myeloid Leukemogenesis and Can Be Inhibited by Rapamycin. Blood. 104: 2532-2532. DOI: 10.1182/Blood.V104.11.2532.2532 |
0.506 |
|
| 2004 |
Shelton JG, Steelman LS, McMahon M, McCubrey JA. Effects of EGF-R on Signal Transduction and Anti-Apoptotic Cascades in Hematopoietic Cells: EGF-R Activates Multiple Signal Transduction Cascades Which Result in the Prevention of Apoptosis in the Absence of Autocrine Cytokines. Blood. 104: 1264-1264. DOI: 10.1182/Blood.V104.11.1264.1264 |
0.466 |
|
| 2003 |
Balmanno K, Millar T, McMahon M, Cook SJ. DeltaRaf-1:ER* bypasses the cyclic AMP block of extracellular signal-regulated kinase 1 and 2 activation but not CDK2 activation or cell cycle reentry. Molecular and Cellular Biology. 23: 9303-17. PMID 14645540 DOI: 10.1128/Mcb.23.24.9303-9317.2003 |
0.455 |
|
| 2003 |
Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernández-del Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw AL, Hebrok M. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 425: 851-6. PMID 14520413 DOI: 10.1038/Nature02009 |
0.413 |
|
| 2003 |
Shelton JG, Moye PW, Steelman LS, Blalock WL, Lee JT, Franklin RA, McMahon M, McCubrey JA. Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia. 17: 1765-82. PMID 12970777 DOI: 10.1038/Sj.Leu.2403052 |
0.44 |
|
| 2003 |
Woodrow MA, Woods D, Cherwinski HM, Stokoe D, McMahon M. Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf-->MEK-->ERK pathway. Experimental Cell Research. 287: 325-38. PMID 12837288 DOI: 10.1016/S0014-4827(03)00122-8 |
0.459 |
|
| 2003 |
Blalock WL, Navolanic PM, Steelman LS, Shelton JG, Moye PW, Lee JT, Franklin RA, Mirza A, McMahon M, White MK, McCubrey JA. Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia. Leukemia. 17: 1058-67. PMID 12764369 DOI: 10.1038/Sj.Leu.2402925 |
0.486 |
|
| 2003 |
Anders M, Christian C, McMahon M, McCormick F, Korn WM. Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells. Cancer Research. 63: 2088-95. PMID 12727824 |
0.329 |
|
| 2003 |
Shelton JG, Steelman LS, Lee JT, Knapp SL, Blalock WL, Moye PW, Franklin RA, Pohnert SC, Mirza AM, McMahon M, McCubrey JA. Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells. Oncogene. 22: 2478-92. PMID 12717425 DOI: 10.1038/Sj.Onc.1206321 |
0.506 |
|
| 2002 |
Lagunoff M, Bechtel J, Venetsanakos E, Roy AM, Abbey N, Herndier B, McMahon M, Ganem D. De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells. Journal of Virology. 76: 2440-8. PMID 11836422 DOI: 10.1128/Jvi.76.5.2440-2448.2002 |
0.313 |
|
| 2002 |
Venetsanakos E, Mirza A, Fanton C, Romanov SR, Tlsty T, McMahon M. Induction of tubulogenesis in telomerase-immortalized human microvascular endothelial cells by glioblastoma cells. Experimental Cell Research. 273: 21-33. PMID 11795943 DOI: 10.1006/Excr.2001.5424 |
0.352 |
|
| 2001 |
Liu Q, Fan J, McMahon M, Prince AM, Zhang P. Role of the oncogenic Raf-1 in orchestration of discrete nuclear factor-kappaB-activating pathways. Molecular Cell Biology Research Communications : McBrc. 4: 381-9. PMID 11703098 DOI: 10.1006/Mcbr.2001.0304 |
0.449 |
|
| 2001 |
Tomlinson MG, Woods DB, McMahon M, Wahl MI, Witte ON, Kurosaki T, Bolen JB, Johnston JA. A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells. Bmc Immunology. 2: 4. PMID 11410123 DOI: 10.1186/1471-2172-2-4 |
0.45 |
|
| 2001 |
Blalock WL, Pearce M, Chang F, Lee JT, Pohnert SC, Burrows C, Steelman LS, Franklin RA, McMahon M, McCubrey JA. Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells. Leukemia. 15: 794-807. PMID 11368441 DOI: 10.1038/Sj.Leu.2402109 |
0.434 |
|
| 2001 |
McMahon M, Woods D. Regulation of the p53 pathway by Ras, the plot thickens Biochimica Et Biophysica Acta. 1471. PMID 11342185 DOI: 10.1016/S0304-419X(00)00027-5 |
0.435 |
|
| 2001 |
Schulze A, Lehmann K, Jefferies HBJ, McMahon M, Downward J. Analysis of the transcriptional program induced by Raf in epithelial cells Genes & Development. 15: 981-994. PMID 11316792 DOI: 10.1101/Gad.191101 |
0.458 |
|
| 2001 |
McMahon M. Steroid receptor fusion proteins for conditional activation of Raf-MEK-ERK signaling pathway Methods in Enzymology. 332: 401-417. PMID 11305114 DOI: 10.1016/S0076-6879(01)32218-8 |
0.389 |
|
| 2001 |
Woods D, Cherwinski H, Venetsanakos E, Bhat A, Gysin S, Humbert M, Bray PF, Saylor VL, McMahon M. Induction of β3-Integrin Gene Expression by Sustained Activation of the Ras-Regulated Raf–MEK–Extracellular Signal-Regulated Kinase Signaling Pathway Molecular and Cellular Biology. 21: 3192-3205. PMID 11287623 DOI: 10.1128/Mcb.21.9.3192-3205.2001 |
0.455 |
|
| 2001 |
Fanton CP, McMahon M, Pieper RO. Dual growth arrest pathways in astrocytes and astrocytic tumors in response to Raf-1 activation. Journal of Biological Chemistry. 276: 18871-18877. PMID 11278920 DOI: 10.1074/Jbc.M011514200 |
0.429 |
|
| 2000 |
Hansen SH, Zegers MM, Woodrow M, Rodriguez-Viciana P, Chardin P, Mostov KE, McMahon M. Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway. Molecular and Cellular Biology. 20: 9364-75. PMID 11094087 DOI: 10.1128/Mcb.20.24.9364-9375.2000 |
0.413 |
|
| 2000 |
Ries S, Biederer C, Woods D, Shifman O, Shirasawa S, Sasazuki T, McMahon M, Oren M, McCormick F. Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell. 103: 321-30. PMID 11057904 DOI: 10.1016/S0092-8674(00)00123-9 |
0.436 |
|
| 2000 |
Lehmann K, Janda E, Pierreux CE, Rytömaa M, Schulze A, McMahon M, Hill CS, Beug H, Downward J. Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes & Development. 14: 2610-2622. PMID 11040215 DOI: 10.1101/Gad.181700 |
0.487 |
|
| 2000 |
Blalock WL, Moye PW, Chang F, Pearce M, Steelman LS, McMahon M, McCubrey JA. Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells. Leukemia. 14: 1080-96. PMID 10865974 DOI: 10.1038/Sj.Leu.2401793 |
0.399 |
|
| 2000 |
Moye PW, Blalock WL, Hoyle PE, Chang F, Franklin RA, Weinstein-Oppenheimer C, Pearce M, Steelman L, McMahon M, McCubrey JA. Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells. Leukemia. 14: 1060-79. PMID 10865973 DOI: 10.1038/Sj.Leu.2401792 |
0.376 |
|
| 2000 |
Hoyle PE, Moye PW, Steelman LS, Blalock WL, Franklin RA, Pearce M, Cherwinski H, Bosch E, McMahon M, McCubrey JA. Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism. Leukemia. 14: 642-56. PMID 10764150 DOI: 10.1038/Sj.Leu.2401720 |
0.476 |
|
| 2000 |
Blalock WL, Pearce M, Steelman LS, Franklin RA, McCarthy SA, Cherwinski H, McMahon M, McCubrey JA. A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells. Oncogene. 19: 526-36. PMID 10698522 DOI: 10.1038/Sj.Onc.1203337 |
0.441 |
|
| 2000 |
Pohnert S, Moye P, Blalock W, Steelman L, Burrows C, McMahon M, Mirza A, McCubrey J. Synergistic effects of akt on abrogation of cytokine-dependency induced by raf and mek Experimental Hematology. 28: 38. DOI: 10.1016/S0301-472X(00)00208-3 |
0.488 |
|
| 1999 |
Ravi RK, Thiagalingam A, Weber E, McMahon M, Nelkin BD, Mabry M. Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells. American Journal of Respiratory Cell and Molecular Biology. 20: 543-549. PMID 10100985 DOI: 10.1165/Ajrcmb.20.4.3406 |
0.503 |
|
| 1999 |
Ravi RK, McMahon M, Yangang Z, Williams JR, Dillehay LE, Nelkin BD, Mabry M. Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells Journal of Cellular Biochemistry. 72: 458-469. PMID 10022606 DOI: 10.1002/(Sici)1097-4644(19990315)72:4<458::Aid-Jcb2>3.0.Co;2-C |
0.431 |
|
| 1999 |
Aziz N, Cherwinski H, McMahon M. Complementation of Defective Colony-Stimulating Factor 1 Receptor Signaling and Mitogenesis by Raf and v-Src Molecular and Cellular Biology. 19: 1101-1115. PMID 9891045 DOI: 10.1128/Mcb.19.2.1101 |
0.472 |
|
| 1999 |
Cook SJ, Aziz N, McMahon M. The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation. Molecular and Cellular Biology. 19: 330-41. PMID 9858557 DOI: 10.1128/Mcb.19.1.330 |
0.39 |
|
| 1998 |
McCubrey JA, Steelman LS, Hoyle PE, Blalock WL, Weinstein-Oppenheimer C, Franklin RA, Cherwinski H, Bosch E, McMahon M. Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells. Leukemia. 12: 1903-29. PMID 9844921 DOI: 10.1038/Sj.Leu.2401215 |
0.5 |
|
| 1998 |
Auer KL, Park JS, Seth P, Coffey RJ, Darlington G, Abo A, McMahon M, Depinho RA, Fisher PB, Dent P. Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice. The Biochemical Journal. 336: 551-60. PMID 9841865 DOI: 10.1042/Bj3360551 |
0.381 |
|
| 1998 |
Zhu J, Woods D, McMahon M, Bishop JM. Senescence of human fibroblasts induced by oncogenic Raf. Genes & Development. 12: 2997-3007. PMID 9765202 DOI: 10.1101/Gad.12.19.2997 |
0.487 |
|
| 1998 |
Fowles LF, Martin ML, Nelsen L, Stacey KJ, Redd D, Clark YM, Nagamine Y, McMahon M, Hume DA, Ostrowski MC. Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating factor 1/c-fms signaling Molecular and Cellular Biology. 18: 5148-5156. PMID 9710599 DOI: 10.1128/Mcb.18.9.5148 |
0.406 |
|
| 1998 |
Onishi M, Nosaka T, Misawa K, Mui ALF, Gorman D, McMahon M, Miyajima A, Kitamura T. Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation Molecular and Cellular Biology. 18: 3871-3879. PMID 9632771 DOI: 10.1128/Mcb.18.7.3871 |
0.387 |
|
| 1998 |
Tombes RM, Auer KL, Mikkelsen R, Valerie K, Wymann MP, Marshall CJ, McMahon M, Dent P. The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic Biochemical Journal. 330: 1451-1460. PMID 9494119 DOI: 10.1042/Bj3301451 |
0.39 |
|
| 1998 |
Ravi RK, Weber E, McMahon M, Williams JR, Baylin S, Mal A, Harter ML, Dillehay LE, Claudio PP, Giordano A, Nelkin BD, Mabry M. Activated Raf-1 causes growth arrest in human small cell lung cancer cells. The Journal of Clinical Investigation. 101: 153-9. PMID 9421477 DOI: 10.1172/Jci831 |
0.537 |
|
| 1997 |
Li D, Lin HH, McMahon M, Ma H, Ann DK. Oncogenic Raf-1 Induces the Expression of Non-histone Chromosomal Architectural Protein HMGI-C via a p44/p42 Mitogen-activated Protein Kinase-dependent Pathway in Salivary Epithelial Cells Journal of Biological Chemistry. 272: 25062-25070. PMID 9312114 DOI: 10.1074/Jbc.272.40.25062 |
0.465 |
|
| 1997 |
McCarthy SA, Aziz N, McMahon M. Identification of immediate-early gene targets of the Raf-1 serine/threonine protein kinase using an estradiol-dependent fusion protein, delta Raf-1:ER. Methods in Molecular Biology (Clifton, N.J.). 85: 137-51. PMID 9276321 DOI: 10.1385/0-89603-489-5:137 |
0.337 |
|
| 1997 |
Woods D, Parry D, Cherwinski H, Bosch E, Lees E, Mcmahon M. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Molecular and Cellular Biology. 17: 5598-5611. PMID 9271435 DOI: 10.1128/Mcb.17.9.5598 |
0.469 |
|
| 1997 |
Cook SJ, Beltman J, Cadwallader KA, McMahon M, McCormick F. Regulation of mitogen-activated protein kinase phosphatase-1 expression by extracellular signal-related kinase-dependent and Ca2+-dependent signal pathways in Rat-1 cells. The Journal of Biological Chemistry. 272: 13309-19. PMID 9148952 DOI: 10.1074/Jbc.272.20.13309 |
0.474 |
|
| 1997 |
Lloyd AC, Obermüller F, Staddon S, Barth CF, McMahon M, Land H. Cooperating oncogenes converge to regulate cyclin/cdk complexes. Genes & Development. 11: 663-77. PMID 9119230 DOI: 10.1101/Gad.11.5.663 |
0.425 |
|
| 1997 |
McCarthy SA, Chen D, Yang BS, Garcia Ramirez JJ, Cherwinski H, Chen XR, Klagsbrun M, Hauser CA, Ostrowski MC, McMahon M. Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1. Molecular and Cellular Biology. 17: 2401-12. PMID 9111309 DOI: 10.1128/Mcb.17.5.2401 |
0.428 |
|
| 1997 |
Pritchard CA, Bolin L, Slattery R, Murray R, McMahon M. Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene. Current Biology : Cb. 6: 614-7. PMID 8805280 DOI: 10.1016/S0960-9822(02)00548-1 |
0.437 |
|
| 1996 |
Klarlund JK, Cherniack AD, McMahon M, Czech MP. Role of the Raf/mitogen-activated protein kinase pathway in p21(ras) desensitization Journal of Biological Chemistry. 271: 16674-16677. PMID 8663295 DOI: 10.1074/Jbc.271.28.16674 |
0.422 |
|
| 1996 |
Lenormand P, McMahon M, Pouysségur J. Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway. Journal of Biological Chemistry. 271: 15762-15768. PMID 8663120 DOI: 10.1074/Jbc.271.26.15762 |
0.458 |
|
| 1996 |
Kuo WL, Abe M, Rhee J, Eves EM, McCarthy SA, Yan M, Templeton DJ, McMahon M, Rosner MR. Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells. Molecular and Cellular Biology. 16: 1458-70. PMID 8657119 DOI: 10.1128/Mcb.16.4.1458 |
0.419 |
|
| 1996 |
Cook S, Beltman J, McMahon M, McCormick F. DIFFERENTIAL REQUIREMENT FOR THE MEK/ERK CASCADE IN REGULATING FOS AND JUN EXPRESSION BY LPA AND EGF IN RAT-1 CELLS Biochemical Society Transactions. 24: 580S-580S. DOI: 10.1042/Bst024580S |
0.379 |
|
| 1995 |
Hambleton J, McMahon M, DeFranco AL. Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events Journal of Experimental Medicine. 182: 147-154. PMID 7790814 DOI: 10.1084/Jem.182.1.147 |
0.363 |
|
| 1995 |
McCarthy SA, Samuels ML, Pritchard CA, Abraham JA, McMahon M. Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes. Genes & Development. 9: 1953-64. PMID 7649477 DOI: 10.1101/Gad.9.16.1953 |
0.443 |
|
| 1995 |
Pritchard CA, Samuels ML, Bosch E, McMahon M. Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells. Molecular and Cellular Biology. 15: 6430-6442. PMID 7565795 DOI: 10.1128/Mcb.15.11.6430 |
0.442 |
|
| 1994 |
Minden A, Lin A, McMahon M, Lange-Carter C, Dérijard B, Davis RJ, Johnson GL, Karin M. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK Science. 266: 1719-1723. PMID 7992057 DOI: 10.1126/Science.7992057 |
0.453 |
|
| 1994 |
Samuels ML, McMahon M. Inhibition of platelet-derived growth factor- and epidermal growth factor-mediated mitogenesis and signaling in 3T3 cells expressing delta Raf-1:ER, an estradiol-regulated form of Raf-1. Molecular and Cellular Biology. 14: 7855-7866. PMID 7969125 DOI: 10.1128/Mcb.14.12.7855 |
0.459 |
|
| 1994 |
Bishop JM, Capobianco AJ, Doyle HJ, Finney RE, McMahon M, Robbins SM, Samuels ML, Vetter M. Proto-oncogenes and plasticity in cell signaling. Cold Spring Harbor Symposia On Quantitative Biology. 59: 165-71. PMID 7587066 DOI: 10.1101/Sqb.1994.059.01.020 |
0.358 |
|
| 1993 |
Samuels ML, Weber MJ, Bishop JM, Mcmahon M. Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase Molecular and Cellular Biology. 13: 6241-6252. PMID 8413224 DOI: 10.1128/mcb.13.10.6241-6252.1993 |
0.438 |
|
| 1991 |
McMahon M, Schatzman RC, Bishop JM. The amino-terminal 14 amino acids of v-src can functionally replace the extracellular and transmembrane domains of v-erbB. Molecular and Cellular Biology. 11: 4760-70. PMID 1678856 DOI: 10.1128/mcb.11.9.4760-4770.1991 |
0.304 |
|
| 1986 |
McMahon M, Stark GR, Kerr IM. Interferon-induced gene expression in wild-type and interferon-resistant human lymphoblastoid (Daudi) cells. Journal of Virology. 57: 362-366. DOI: 10.1128/Jvi.57.1.362-366.1986 |
0.327 |
|
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