Gwenn A. Garden, MD/PhD - Publications

Affiliations: 
2000-2019 Neurology, Neurobiology and Behavior University of Washington, Seattle, Seattle, WA 
 2019- Neurology University of North Carolina at Chapel Hill School of Medicine 
Area:
Neuroscience Biology

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Aloi MS, Prater KE, Sánchez REA, Beck A, Pathan JL, Davidson S, Wilson A, Keene CD, de la Iglesia H, Jayadev S, Garden GA. Microglia specific deletion of miR-155 in Alzheimer's disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures. Journal of Neuroinflammation. 20: 60. PMID 36879321 DOI: 10.1186/s12974-023-02745-6  0.765
2021 Prater KE, Aloi MS, Pathan JL, Winston CN, Chernoff RA, Davidson SL, Sadgrove M, McDonough A, Zierath DK, Su W, Weinstein JR, Garden GA. A subpopulation of microglia generated in the adult mouse brain originate from prominin-1 expressing progenitors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34380760 DOI: 10.1523/JNEUROSCI.1893-20.2021  0.768
2021 Aloi MS, Prater KE, Sopher B, Davidson S, Jayadev S, Garden GA. The pro-inflammatory microRNA miR-155 influences fibrillar β-Amyloid catabolism by microglia. Glia. PMID 33694209 DOI: 10.1002/glia.23988  0.76
2019 McDonough A, Noor S, Lee RV, Dodge R, Strosnider JS, Shen J, Davidson S, Möller T, Garden GA, Weinstein JR. Ischemic preconditioning induces cortical microglial proliferation and a transcriptomic program of robust cell cycle activation. Glia. PMID 31420975 DOI: 10.1002/Glia.23701  0.372
2019 Braggin JE, Bucks SA, Course MM, Smith CL, Sopher B, Osnis L, Shuey KD, Domoto-Reilly K, Caso C, Kinoshita C, Scherpelz KP, Cross C, Grabowski T, Nik SHM, Newman M, ... Garden GA, et al. Alternative splicing in a presenilin 2 variant associated with Alzheimer disease. Annals of Clinical and Translational Neurology. 6: 762-777. PMID 31020001 DOI: 10.1002/Acn3.755  0.31
2019 Green K, Blue E, Logsdon BA, Rolf B, Rose S, Knupp A, Frankowski H, Braggin JE, Martinez RA, Dorschner M, Young JE, Keene CDD, Garden GA, Jayadev S. P4-479: Methods To Assess Cell-Type-Specific, Biological Networks Of Alzheimer'S Disease Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.08.025  0.322
2018 Wang DB, Kinoshita C, Kinoshita Y, Sopher BL, Uo T, Lee RJ, Kim JK, Murphy SP, Keene CD, Garden GA, Morrison RS. Neuronal Susceptibility to Beta-Amyloid Toxicity and Ischemic Injury Involves Histone Deacetylase-2 Regulation of Endophilin-B1. Brain Pathology (Zurich, Switzerland). PMID 30028551 DOI: 10.1111/Bpa.12647  0.347
2018 Green K, Blue E, Logsdon BA, Rolf B, Rose S, Knupp A, Frankowski H, Latimer CS, Keene D, Young JE, Dorschner M, Garden GA, Jayadev S. P4-230: A Genomic And Cell Function Approach To Identifying Cell-Type-Specific Biological Networks In Alzheimer'S Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.07.051  0.328
2017 Amos PJ, Fung S, Case A, Kifelew J, Osnis L, Smith CL, Green K, Naydenov A, Aloi M, Hubbard JJ, Ramakrishnan A, Garden GA, Jayadev S. Modulation of Hematopoietic Lineage Specification Impacts TREM2 Expression in Microglia-Like Cells Derived From Human Stem Cells. Asn Neuro. 9: 1759091417716610. PMID 28683563 DOI: 10.1177/1759091417716610  0.762
2016 Garden GA, Campbell BM. Glial biomarkers in human central nervous system disease. Glia. PMID 27228454 DOI: 10.1002/Glia.22998  0.375
2015 Aloi MS, Su W, Garden GA. The p53 Transcriptional Network Influences Microglia Behavior and Neuroinflammation. Critical Reviews in Immunology. 35: 401-15. PMID 26853851 DOI: 10.1615/Critrevimmunol.V35.I5.40  0.763
2015 Su W, Aloi MS, Garden GA. MicroRNAs mediating CNS inflammation: Small regulators with powerful potential. Brain, Behavior, and Immunity. PMID 26148445 DOI: 10.1016/J.Bbi.2015.07.003  0.754
2015 Korvatska O, Leverenz JB, Jayadev S, McMillan P, Kurtz I, Guo X, Rumbaugh M, Matsushita M, Girirajan S, Dorschner MO, Kiianitsa K, Yu CE, Brkanac Z, Garden GA, Raskind WH, et al. R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study. Jama Neurology. PMID 26076170 DOI: 10.1001/Jamaneurol.2015.0979  0.36
2015 Wang DB, Kinoshita Y, Kinoshita C, Uo T, Sopher BL, Cudaback E, Keene CD, Bilousova T, Gylys K, Case A, Jayadev S, Wang HG, Garden GA, Morrison RS. Loss of endophilin-B1 exacerbates Alzheimer's disease pathology. Brain : a Journal of Neurology. 138: 2005-19. PMID 25981964 DOI: 10.1093/Brain/Awv128  0.367
2015 Jebelli J, Su W, Hopkins S, Pocock J, Garden GA. Glia: guardians, gluttons, or guides for the maintenance of neuronal connectivity? Annals of the New York Academy of Sciences. PMID 25752338 DOI: 10.1111/Nyas.12711  0.378
2015 Su W, Kang J, Sopher B, Gillespie J, Aloi MS, Odom GL, Hopkins S, Case A, Wang DB, Chamberlain JS, Garden GA. Recombinant adeno-associated viral (rAAV) vectors mediate efficient gene transduction in cultured neonatal and adult microglia. Journal of Neurochemistry. PMID 25708596 DOI: 10.1111/Jnc.13081  0.761
2015 Fung S, Amos P, Case A, Ramakrishnan A, Neumann H, Garden GA, Jayadev S. Familial Alzheimer's disease PSEN2 mutations regulate inflammatory micrornas in microglia Alzheimers & Dementia. 11: 184. DOI: 10.1016/J.Jalz.2015.07.156  0.344
2014 Hu R, Kagele DA, Huffaker TB, Runtsch MC, Alexander M, Liu J, Bake E, Su W, Williams MA, Rao DS, Möller T, Garden GA, Round JL, O'Connell RM. miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation. Immunity. 41: 605-19. PMID 25367574 DOI: 10.1016/J.Immuni.2014.09.015  0.376
2014 Cortes CJ, Miranda HC, Frankowski H, Batlevi Y, Young JE, Le A, Ivanov N, Sopher BL, Carromeu C, Muotri AR, Garden GA, La Spada AR. Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. Nature Neuroscience. 17: 1180-9. PMID 25108912 DOI: 10.1038/Nn.3787  0.346
2014 Maung R, Hoefer MM, Sanchez AB, Sejbuk NE, Medders KE, Desai MK, Catalan IC, Dowling CC, de Rozieres CM, Garden GA, Russo R, Roberts AJ, Williams R, Kaul M. CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120. Journal of Immunology (Baltimore, Md. : 1950). 193: 1895-910. PMID 25031461 DOI: 10.4049/Jimmunol.1302915  0.401
2014 Wang DB, Uo T, Kinoshita C, Sopher BL, Lee RJ, Murphy SP, Kinoshita Y, Garden GA, Wang HG, Morrison RS. Bax interacting factor-1 promotes survival and mitochondrial elongation in neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 2674-83. PMID 24523556 DOI: 10.1523/Jneurosci.4074-13.2014  0.336
2014 Su W, Hopkins S, Nesser NK, Sopher B, Silvestroni A, Ammanuel S, Jayadev S, Möller T, Weinstein J, Garden GA. The p53 transcription factor modulates microglia behavior through microRNA-dependent regulation of c-Maf. Journal of Immunology (Baltimore, Md. : 1950). 192: 358-66. PMID 24319262 DOI: 10.4049/Jimmunol.1301397  0.41
2013 Garden GA. Epigenetics and the modulation of neuroinflammation. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 10: 782-8. PMID 23963788 DOI: 10.1007/S13311-013-0207-4  0.375
2013 Jayadev S, Case A, Alajajian B, Eastman AJ, Möller T, Garden GA. Presenilin 2 influences miR146 level and activity in microglia. Journal of Neurochemistry. 127: 592-9. PMID 23952003 DOI: 10.1111/Jnc.12400  0.45
2013 Wang DB, Garden GA, Kinoshita C, Wyles C, Babazadeh N, Sopher B, Kinoshita Y, Morrison RS. Declines in Drp1 and parkin expression underlie DNA damage-induced changes in mitochondrial length and neuronal death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 1357-65. PMID 23345212 DOI: 10.1523/Jneurosci.3365-12.2013  0.311
2013 Furrer SA, Waldherr SM, Mohanachandran MS, Baughn TD, Nguyen KT, Sopher BL, Damian VA, Garden GA, La Spada AR. Reduction of mutant ataxin-7 expression restores motor function and prevents cerebellar synaptic reorganization in a conditional mouse model of SCA7. Human Molecular Genetics. 22: 890-903. PMID 23197655 DOI: 10.1093/Hmg/Dds495  0.742
2012 Garden GA, La Spada AR. Intercellular (mis)communication in neurodegenerative disease. Neuron. 73: 886-901. PMID 22405200 DOI: 10.1016/J.Neuron.2012.02.017  0.407
2012 Jebelli JD, Hooper C, Garden GA, Pocock JM. Emerging roles of p53 in glial cell function in health and disease. Glia. 60: 515-25. PMID 22105777 DOI: 10.1002/Glia.22268  0.375
2011 Furrer SA, Mohanachandran MS, Waldherr SM, Chang C, Damian VA, Sopher BL, Garden GA, La Spada AR. Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16269-78. PMID 22072678 DOI: 10.1523/Jneurosci.4000-11.2011  0.743
2011 Jayadev S, Nesser NK, Hopkins S, Myers SJ, Case A, Lee RJ, Seaburg LA, Uo T, Murphy SP, Morrison RS, Garden GA. Transcription factor p53 influences microglial activation phenotype. Glia. 59: 1402-13. PMID 21598312 DOI: 10.1002/Glia.21178  0.401
2010 Jayadev S, Case A, Eastman AJ, Nguyen H, Pollak J, Wiley JC, Möller T, Morrison RS, Garden GA. Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release. Plos One. 5: e15743. PMID 21206757 DOI: 10.1371/Journal.Pone.0015743  0.339
2010 Guyenet SJ, Furrer SA, Damian VM, Baughan TD, La Spada AR, Garden GA. A simple composite phenotype scoring system for evaluating mouse models of cerebellar ataxia. Journal of Visualized Experiments : Jove. PMID 20495529 DOI: 10.3791/1787  0.719
2009 Chakrabarti L, Eng J, Ivanov N, Garden GA, La Spada AR. Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death. Molecular Brain. 2: 24. PMID 19640278 DOI: 10.1186/1756-6606-2-24  0.397
2009 Klintworth H, Garden G, Xia Z. Rotenone and paraquat do not directly activate microglia or induce inflammatory cytokine release. Neuroscience Letters. 462: 1-5. PMID 19559752 DOI: 10.1016/J.Neulet.2009.06.065  0.37
2009 Young JE, Garden GA, Martinez RA, Tanaka F, Sandoval CM, Smith AC, Sopher BL, Lin A, Fischbeck KH, Ellerby LM, Morrison RS, Taylor JP, La Spada AR. Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1987-97. PMID 19228953 DOI: 10.1523/Jneurosci.4072-08.2009  0.357
2008 Garden GA, La Spada AR. Molecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegeneration. Cerebellum (London, England). 7: 138-49. PMID 18418675 DOI: 10.1007/S12311-008-0027-Y  0.405
2007 Jayadev S, Yun B, Nguyen H, Yokoo H, Morrison RS, Garden GA. The glial response to CNS HIV infection includes p53 activation and increased expression of p53 target genes. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 2: 359-70. PMID 18040854 DOI: 10.1007/S11481-007-9095-X  0.364
2007 Tun C, Guo W, Nguyen H, Yun B, Libby RT, Morrison RS, Garden GA. Activation of the extrinsic caspase pathway in cultured cortical neurons requires p53-mediated down-regulation of the X-linked inhibitor of apoptosis protein to induce apoptosis. Journal of Neurochemistry. 102: 1206-19. PMID 17488272 DOI: 10.1111/J.1471-4159.2007.04609.X  0.312
2006 Garden GA, Möller T. Microglia biology in health and disease. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 1: 127-37. PMID 18040779 DOI: 10.1007/S11481-006-9015-5  0.392
2006 Kinoshita Y, Uo T, Jayadev S, Garden GA, Conrads TP, Veenstra TD, Morrison RS. Potential applications and limitations of proteomics in the study of neurological disease. Archives of Neurology. 63: 1692-6. PMID 17172608 DOI: 10.1001/Archneur.63.12.1692  0.318
2006 Custer SK, Garden GA, Gill N, Rueb U, Libby RT, Schultz C, Guyenet SJ, Deller T, Westrum LE, Sopher BL, La Spada AR. Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport. Nature Neuroscience. 9: 1302-11. PMID 16936724 DOI: 10.1038/Nn1750  0.427
2005 Garden GA, Morrison RS. The multiple roles of p53 in the pathogenesis of HIV associated dementia. Biochemical and Biophysical Research Communications. 331: 799-809. PMID 15865935 DOI: 10.1016/J.Bbrc.2005.03.185  0.306
2004 Digicaylioglu M, Garden G, Timberlake S, Fletcher L, Lipton SA. Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I. Proceedings of the National Academy of Sciences of the United States of America. 101: 9855-60. PMID 15210945 DOI: 10.1073/pnas.0403172101  0.399
2004 Garden GA, Guo W, Jayadev S, Tun C, Balcaitis S, Choi J, Montine TJ, Möller T, Morrison RS. HIV associated neurodegeneration requires p53 in neurons and microglia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1141-3. PMID 15155568 DOI: 10.1096/Fj.04-1676Fje  0.338
2004 Hu S, Walker M, Czartoski T, Cheng A, Forghani B, Gilden DH, Garden GA. Acyclovir responsive brain stem disease after the Ramsay Hunt syndrome Journal of the Neurological Sciences. 217: 111-113. PMID 14675618 DOI: 10.1016/J.Jns.2003.08.011  0.523
2003 Morrison RS, Kinoshita Y, Johnson MD, Guo W, Garden GA. p53-dependent cell death signaling in neurons. Neurochemical Research. 28: 15-27. PMID 12587660 DOI: 10.1023/A:1021687810103  0.387
2002 Morrison RS, Kinoshita Y, Johnson MD, Ghatan S, Ho JT, Garden G. Neuronal survival and cell death signaling pathways. Advances in Experimental Medicine and Biology. 513: 41-86. PMID 12575817 DOI: 10.1007/978-1-4615-0123-7_2  0.314
2002 Garden GA. Microglia in human immunodeficiency virus-associated neurodegeneration. Glia. 40: 240-51. PMID 12379911 DOI: 10.1002/Glia.10155  0.327
2002 Garden GA, Libby RT, Fu YH, Kinoshita Y, Huang J, Possin DE, Smith AC, Martinez RA, Fine GC, Grote SK, Ware CB, Einum DD, Morrison RS, Ptacek LJ, Sopher BL, et al. Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4897-905. PMID 12077187 DOI: 10.1523/Jneurosci.22-12-04897.2002  0.436
2002 Garden GA, Budd SL, Tsai E, Hanson L, Kaul M, D'Emilia DM, Friedlander RM, Yuan J, Masliah E, Lipton SA. Caspase cascades in human immunodeficiency virus-associated neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4015-24. PMID 12019321 DOI: 10.1523/Jneurosci.22-10-04015.2002  0.491
2001 Kaul M, Garden GA, Lipton SA. Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature. 410: 988-94. PMID 11309629 DOI: 10.1038/35073667  0.505
1995 Garden GA, Redeker-DeWulf V, Rubel EW. Afferent influences on brainstem auditory nuclei of the chicken: regulation of transcriptional activity following cochlea removal. The Journal of Comparative Neurology. 359: 412-23. PMID 7499538 DOI: 10.1002/Cne.903590305  0.499
1995 Garden GA, Hartlage-Rübsamen M, Rubel EW, Bothwell MA. Protein masking of a ribosomal RNA epitope is an early event in afferent deprivation-induced neuronal death. Molecular and Cellular Neurosciences. 6: 293-310. PMID 7496633 DOI: 10.1006/Mcne.1995.1023  0.516
1994 Garden GA, Canady KS, Lurie DI, Bothwell M, Rubel EW. A biphasic change in ribosomal conformation during transneuronal degeneration is altered by inhibition of mitochondrial, but not cytoplasmic protein synthesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 1994-2008. PMID 8158254 DOI: 10.1523/Jneurosci.14-04-01994.1994  0.502
1991 Garden GA, Bothwell M, Rubel EW. Lack of correspondence between mRNA expression for a putative cell death molecule (SGP-2) and neuronal cell death in the central nervous system. Journal of Neurobiology. 22: 590-604. PMID 1919566 DOI: 10.1002/Neu.480220605  0.554
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