| Year |
Citation |
Score |
| 2019 |
Shah K, Queener S, Cody V, Pace J, Gangjee A. Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection. Bioorganic & Medicinal Chemistry Letters. PMID 31176699 DOI: 10.1016/J.Bmcl.2019.06.004 |
0.458 |
|
| 2018 |
Shah K, Lin X, Queener SF, Cody V, Pace J, Gangjee A. Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents. Bioorganic & Medicinal Chemistry. PMID 29691153 DOI: 10.1016/J.Bmc.2018.04.032 |
0.42 |
|
| 2016 |
Gangjee A, Mavandadi F, Kisliuk RL, McGuire JJ, Queener SF. 2-Amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as Nonclassical Antifolate Inhibitors of Thymidylate Synthase. Journal of Medicinal Chemistry. 40: 632. PMID 27518693 DOI: 10.1021/Jm960843U |
0.375 |
|
| 2013 |
Zaware N, Sharma H, Yang J, Devambatla RK, Queener SF, Anderson KS, Gangjee A. Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections. Acs Medicinal Chemistry Letters. 4: 1148-1151. PMID 24470841 DOI: 10.1021/Ml400208V |
0.393 |
|
| 2013 |
Queener SF, Cody V, Pace J, Torkelson P, Gangjee A. Trimethoprim resistance of dihydrofolate reductase variants from clinical isolates of Pneumocystis jirovecii. Antimicrobial Agents and Chemotherapy. 57: 4990-8. PMID 23896474 DOI: 10.1128/Aac.01161-13 |
0.323 |
|
| 2013 |
Gangjee A, Namjoshi OA, Raghavan S, Queener SF, Kisliuk RL, Cody V. Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles. Journal of Medicinal Chemistry. 56: 4422-41. PMID 23627352 DOI: 10.1021/Jm400086G |
0.41 |
|
| 2013 |
Cody V, Pace J, Queener SF, Adair OO, Gangjee A. Kinetic and structural analysis for potent antifolate inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and human dihydrofolate reductases and their active-site variants. Antimicrobial Agents and Chemotherapy. 57: 2669-77. PMID 23545530 DOI: 10.1128/Aac.00172-13 |
0.413 |
|
| 2013 |
Konrad C, Queener SF, Wek RC, Sullivan WJ. Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii. Antimicrobial Agents and Chemotherapy. 57: 1815-22. PMID 23380722 DOI: 10.1128/Aac.01899-12 |
0.313 |
|
| 2011 |
Cody V, Pace J, Piraino J, Queener SF. Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase. Journal of Structural Biology. 176: 52-9. PMID 21684339 DOI: 10.1016/J.Jsb.2011.06.001 |
0.307 |
|
| 2010 |
Bag S, Tawari NR, Degani MS, Queener SF. Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens. Bioorganic & Medicinal Chemistry. 18: 3187-97. PMID 20363634 DOI: 10.1016/J.Bmc.2010.03.031 |
0.397 |
|
| 2010 |
Gangjee A, Jain HD, Phan J, Guo X, Queener SF, Kisliuk RL. 2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors. Bioorganic & Medicinal Chemistry. 18: 953-61. PMID 20056546 DOI: 10.1016/J.Bmc.2009.11.029 |
0.457 |
|
| 2010 |
Bag S, Tawari NR, Queener SF, Degani MS. Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms. Journal of Enzyme Inhibition and Medicinal Chemistry. 25: 331-9. PMID 19874136 DOI: 10.3109/14756360903179443 |
0.301 |
|
| 2010 |
Degani MS, Bag S, Bairwa R, Tawari NR, Queener SF. Novel 2‐hydrazino‐pyrimidin‐4(3H)‐one derivatives as potential dihydrofolate reductase inhibitors Journal of Heterocyclic Chemistry. 47: 558-563. DOI: 10.1002/Jhet.216 |
0.395 |
|
| 2009 |
Pedró Rosa LE, Reddy DR, Queener SF, Miller LW. Selective antifolates for chemically labeling proteins in mammalian cells. Chembiochem : a European Journal of Chemical Biology. 10: 1462-4. PMID 19437525 DOI: 10.1002/Cbic.200900152 |
0.42 |
|
| 2009 |
Cody V, Pace J, Makin J, Piraino J, Queener SF, Rosowsky A. Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes. Biochemistry. 48: 1702-11. PMID 19196009 DOI: 10.1021/Bi801960H |
0.362 |
|
| 2009 |
Gangjee A, Pagley OOAM, Queener SF. N9-substituted 2,4-diaminoquinazolines: Synthesis and biological evaluation of lipophilic inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase (Journal of Medicinal Chemistry (2008) 51, (6196) DOI: 10.1021/jm800694g) Journal of Medicinal Chemistry. 52: 4979. DOI: 10.1021/Jm900938H |
0.373 |
|
| 2008 |
Gangjee A, Adair OO, Pagley M, Queener SF. N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase. Journal of Medicinal Chemistry. 51: 6195-200. PMID 18771252 DOI: 10.1021/Jm800694G |
0.363 |
|
| 2008 |
Cody V, Mao Q, Queener SF. Recombinant bovine dihydrofolate reductase produced by mutagenesis and nested PCR of murine dihydrofolate reductase cDNA. Protein Expression and Purification. 62: 104-10. PMID 18672067 DOI: 10.1016/J.Pep.2008.07.001 |
0.376 |
|
| 2008 |
Gangjee A, Jain HD, Queener SF, Kisliuk RL. The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents. Journal of Medicinal Chemistry. 51: 4589-600. PMID 18605720 DOI: 10.1021/Jm800244V |
0.455 |
|
| 2008 |
Mui EJ, Schiehser GA, Milhous WK, Hsu H, Roberts CW, Kirisits M, Muench S, Rice D, Dubey JP, Fowble JW, Rathod PK, Queener SF, Liu SR, Jacobus DP, McLeod R. Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo. Plos Neglected Tropical Diseases. 2: e190. PMID 18320016 DOI: 10.1371/Journal.Pntd.0000190 |
0.316 |
|
| 2007 |
Reynolds RC, Campbell SR, Fairchild RG, Kisliuk RL, Micca PL, Queener SF, Riordan JM, Sedwick WD, Waud WR, Leung AK, Dixon RW, Suling WJ, Borhani DW. Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation. Journal of Medicinal Chemistry. 50: 3283-9. PMID 17569517 DOI: 10.1021/Jm0701977 |
0.379 |
|
| 2007 |
Gangjee A, Zeng Y, Talreja T, McGuire JJ, Kisliuk RL, Queener SF. Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates. Journal of Medicinal Chemistry. 50: 3046-53. PMID 17552508 DOI: 10.1021/Jm070165J |
0.434 |
|
| 2007 |
Smith AT, Livingston MR, Mai A, Filetici P, Queener SF, Sullivan WJ. Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii. Antimicrobial Agents and Chemotherapy. 51: 1109-11. PMID 17178801 DOI: 10.1128/Aac.01256-06 |
0.36 |
|
| 2006 |
Gangjee A, Yang J, Queener SF. Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3-d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents. Bioorganic & Medicinal Chemistry. 14: 8341-51. PMID 17010625 DOI: 10.1016/J.Bmc.2006.09.008 |
0.312 |
|
| 2006 |
Gangjee A, Wang Y, Queener SF, Kisliuk RL. Synthesis of 2,6-diamino-5-[(2-substituted phenylamino)ethyl]pyrimidin- 4(3H)-one as inhibitors of folate metabolizing enzymes Journal of Heterocyclic Chemistry. 43: 1523-1531. DOI: 10.1002/Jhet.5570430615 |
0.397 |
|
| 2005 |
Chan DC, Fu H, Forsch RA, Queener SF, Rosowsky A. Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain. Journal of Medicinal Chemistry. 48: 4420-31. PMID 15974594 DOI: 10.1021/Jm0581718 |
0.421 |
|
| 2005 |
Sullivan WJ, Dixon SE, Li C, Striepen B, Queener SF. IMP dehydrogenase from the protozoan parasite Toxoplasma gondii. Antimicrobial Agents and Chemotherapy. 49: 2172-9. PMID 15917510 DOI: 10.1128/Aac.49.6.2172-2179.2005 |
0.406 |
|
| 2005 |
Cody V, Chisum K, Pope C, Queener SF. Purification and characterization of human-derived Pneumocystis jirovecii dihydrofolate reductase expressed in Sf21 insect cells and in Escherichia coli. Protein Expression and Purification. 40: 417-23. PMID 15766885 DOI: 10.1016/J.Pep.2004.12.028 |
0.409 |
|
| 2005 |
Gangjee A, Jain HD, Queener SF. Design, synthesis and biological evaluation of 2,4-diamino-6-methyl-5- substitutedpyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors Journal of Heterocyclic Chemistry. 42: 589-594. DOI: 10.1002/CHIN.200541160 |
0.315 |
|
| 2004 |
Gangjee A, Lin X, Queener SF. Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors. Journal of Medicinal Chemistry. 47: 3689-92. PMID 15214795 DOI: 10.1021/Jm0306327 |
0.414 |
|
| 2004 |
Rosowsky A, Fu H, Chan DC, Queener SF. Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase. Journal of Medicinal Chemistry. 47: 2475-85. PMID 15115391 DOI: 10.1021/Jm030599O |
0.322 |
|
| 2004 |
Graffner-Nordberg M, Kolmodin K, Aqvist J, Queener SF, Hallberg A. Design, synthesis, and computational affinity prediction of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 22: 43-54. PMID 15113582 DOI: 10.1016/J.Ejps.2004.02.004 |
0.327 |
|
| 2004 |
Cody V, Luft JR, Pangborn W, Gangjee A, Queener SF. Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallographica. Section D, Biological Crystallography. 60: 646-55. PMID 15039552 DOI: 10.1107/S0907444904002094 |
0.319 |
|
| 2004 |
Forsch RA, Queener SF, Rosowsky A. Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium. Bioorganic & Medicinal Chemistry Letters. 14: 1811-5. PMID 15026078 DOI: 10.1016/J.Bmcl.2003.12.103 |
0.369 |
|
| 2004 |
Rosowsky A, Forsch RA, Sibley CH, Inderlied CB, Queener SF. New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity. Journal of Medicinal Chemistry. 47: 1475-86. PMID 14998335 DOI: 10.1021/Jm030438K |
0.421 |
|
| 2004 |
Rosowsky A, Forsch RA, Sibley CH, Inderlied CB, Queener SF. Erratum: New 2,4-diamino-5-(2′,5′-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity (Journal of Medicinal Chemistry (2004) 47 (1479)) Journal of Medicinal Chemistry. 47. DOI: 10.1021/Jm040098I |
0.305 |
|
| 2004 |
Forsch RA, Queener SF, Rosowsky A. Corrigendum to ?Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium?6Bioorg. Med. Chem. Lett. 14 (2004) 18119 Bioorganic & Medicinal Chemistry Letters. 14: 2693. DOI: 10.1016/S0960-894X(04)00361-0 |
0.314 |
|
| 2004 |
Forsch RA, Queener SF, Rosowsky A. Erratum: Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium (Bioorganic and Medicinal Chemistry Letters (2004) 14 (1811) DOI: 10.1016/j.bmcl.2003.12.103) Bioorganic & Medicinal Chemistry Letters. 14. DOI: 10.1016/J.Bmcl.2004.03.026 |
0.316 |
|
| 2003 |
Gangjee A, Adair OO, Queener SF. Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents. Journal of Medicinal Chemistry. 46: 5074-82. PMID 14584957 DOI: 10.1021/Jm030312N |
0.475 |
|
| 2003 |
Donkor IO, Li H, Queener SF. Synthesis and DHFR inhibitory activity of a series of 6-substituted-2,4-diaminothieno[2,3-d]pyrimidines. European Journal of Medicinal Chemistry. 38: 605-11. PMID 12832132 DOI: 10.1016/S0223-5234(03)00101-6 |
0.397 |
|
| 2003 |
Sullivan WJ, Monroy MA, Bohne W, Nallani KC, Chrivia J, Yaciuk P, Smith CK, Queener SF. Molecular cloning and characterization of an SRCAP chromatin remodeling homologue in Toxoplasma gondii. Parasitology Research. 90: 1-8. PMID 12743798 DOI: 10.1007/S00436-002-0814-1 |
0.303 |
|
| 2003 |
Rosowsky A, Forsch RA, Queener SF. Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS. Journal of Medicinal Chemistry. 46: 1726-36. PMID 12699390 DOI: 10.1021/Jm020466N |
0.442 |
|
| 2003 |
Rosowsky A, Chen H, Fu H, Queener SF. Synthesis of new 2,4-Diaminopyrido[2,3-d]pyrimidine and 2,4-Diaminopyrrolo[2,3-d]pyrimidine inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase. Bioorganic & Medicinal Chemistry. 11: 59-67. PMID 12467708 DOI: 10.1016/S0968-0896(02)00325-5 |
0.449 |
|
| 2003 |
Gangjee A, Lin X, Queener SF. 7-Methyl trimethoprim analogues as inhibitors of the folate metabolizing enzymes Journal of Heterocyclic Chemistry. 40: 507-512. |
0.339 |
|
| 2002 |
Cody V, Galitsky N, Luft JR, Pangborn W, Queener SF, Gangjee A. Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase. Acta Crystallographica. Section D, Biological Crystallography. 58: 1393-9. PMID 12198294 DOI: 10.1107/S0907444902010442 |
0.308 |
|
| 2002 |
Chan DC, Laughton CA, Queener SF, Stevens MF. Structural studies on bioactive compounds. Part 36: design, synthesis and biological evaluation of pyrimethamine-based antifolates against Pneumocystis carinii. Bioorganic & Medicinal Chemistry. 10: 3001-10. PMID 12110323 DOI: 10.1016/S0968-0896(02)00128-1 |
0.397 |
|
| 2002 |
Cody V, Galitsky N, Luft JR, Pangborn W, Rosowsky A, Queener SF. Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH. Acta Crystallographica. Section D, Biological Crystallography. 58: 946-54. PMID 12037296 DOI: 10.1107/S090744490200505X |
0.346 |
|
| 2002 |
Rosowsky A, Forsch RA, Queener SF. Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim. Journal of Medicinal Chemistry. 45: 233-41. PMID 11754594 DOI: 10.1021/Jm010407U |
0.449 |
|
| 2001 |
Gangjee A, Adair O, Queener SF. Synthesis of 2,4-Diamino-6-(thioarylmethyl)pyrido[2,3-d]pyrimidines as dihydrofolate reductase inhibitors Bioorganic and Medicinal Chemistry. 9: 2929-2935. PMID 11597474 DOI: 10.1016/S0968-0896(01)00223-1 |
0.44 |
|
| 2001 |
Huang TL, Tao B, Quarshie Y, Queener SF, Donkor IO. N,N′-Bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents Bioorganic and Medicinal Chemistry Letters. 11: 2679-2681. PMID 11591500 DOI: 10.1016/S0960-894X(01)00541-8 |
0.356 |
|
| 2001 |
Wang Y, Bruenn JA, Queener SF, Cody V. Isolation of rat dihydrofolate reductase gene and characterization of recombinant enzyme Antimicrobial Agents and Chemotherapy. 45: 2517-2523. PMID 11502523 DOI: 10.1128/Aac.45.9.2517-2523.2001 |
0.408 |
|
| 2001 |
Chan DCM, Laughton CA, Queener SF, Stevens MFG. Structural studies on bioactive compounds. 34.1 Design, synthesis, and biological evaluation of triazenyl-substituted pyrimethamine inhibitors of Pneumocystis carinii dihydrofolate reductase Journal of Medicinal Chemistry. 44: 2555-2564. PMID 11472209 DOI: 10.1021/Jm0108698 |
0.438 |
|
| 2001 |
Graffner-Nordberg M, Kolmodin K, Åqvist J, Queener SF, Hallberg A. Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from pneumocystis carinii Journal of Medicinal Chemistry. 44: 2391-2402. PMID 11448221 DOI: 10.1021/Jm010856U |
0.403 |
|
| 2001 |
Gangjee A, Vidwans A, Elzein E, McGuire JJ, Queener SF, Kisliuk RL. Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines Journal of Medicinal Chemistry. 44: 1993-2003. PMID 11384244 DOI: 10.1021/Jm0100382 |
0.478 |
|
| 2001 |
Ye D, Lee CH, Queener SF. Differential splicing of Pneumocystis carinii f. sp. carinii inosine 5'-monophosphate dehydrogenase pre-mRNA. Gene. 263: 151-8. PMID 11223253 DOI: 10.1016/S0378-1119(00)00577-1 |
0.61 |
|
| 2001 |
Rosowsky A, Fu H, Queener SF. Synthesis of new 2,4‐diamino‐7H‐pyrrolo[2,3‐d]pyrimidines via the Taylor ring transformation/ring annulation strategy Journal of Heterocyclic Chemistry. 38: 1197-1202. DOI: 10.1002/Jhet.5570380526 |
0.428 |
|
| 2001 |
Rosowsky A, Fu H, Queener SF. Synthesis of new 2,4-diamino-7H-pyrrolo[2,3-d]pyrimidines via the Taylor ring transformation/ring annulation strategy Journal of Heterocyclic Chemistry. 38: 1197-1202. |
0.303 |
|
| 2000 |
Gangjee A, Yu J, McGuire JJ, Cody V, Galitsky N, Kisliuk RL, Queener SF. Design, synthesis, and x-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent Journal of Medicinal Chemistry. 43: 3837-3851. PMID 11052789 DOI: 10.1021/Jm000200L |
0.38 |
|
| 2000 |
Cody V, Chan D, Galitsky N, Rak D, Luft JR, Pangborn W, Queener SF, Laughton CA, Stevens MF. Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate. Biochemistry. 39: 3556-64. PMID 10736154 DOI: 10.1021/Bi9924563 |
0.341 |
|
| 2000 |
Gangjee A, Dubash NP, Queener SF. The synthesis of new 2,4-diaminofuro[2,3-d]pyrimidines with 5-biphenyl, phenoxyphenyl and tricyclic substitutions as dihydrofolate reductase inhibitors Journal of Heterocyclic Chemistry. 37: 935-942. DOI: 10.1002/Jhet.5570370442 |
0.431 |
|
| 2000 |
Rosowsky A, Fu H, Queener SF. Synthesis of 2,4-diaminopyrido[2,3-d]pyrimidines and 2,4-diamino-quinazolines with bulky dibenz[b,f]azepine and dibenzo[a,d]-cycloheptene substituents at the 6-position as inhibitors of dihydrofolate reductases from Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium Journal of Heterocyclic Chemistry. 37: 921-926. DOI: 10.1002/Jhet.5570370440 |
0.454 |
|
| 1999 |
Rosowsky A, Cody V, Galitsky N, Fu H, Papoulis AT, Queener SF. Structure-based design of selective inhibitors of dihydrofolate reductase: Synthesis and antiparasitic activity of 2,4-diaminopteridine analogues with a bridged diarylamine side chain Journal of Medicinal Chemistry. 42: 4853-4860. PMID 10579848 DOI: 10.1021/Jm990331Q |
0.436 |
|
| 1999 |
Gangjee A, Adair O, Queener SF. Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: Synthesis and biological activities of 2,4- diamino-5-methyl-6-[(monosubstituted anilino)methyl]pyrido[2,3-d]pyrimidines Journal of Medicinal Chemistry. 42: 2447-2455. PMID 10395486 DOI: 10.1021/Jm990079M |
0.408 |
|
| 1999 |
Gangjee A, Mavandadi F, Kisliuk RL, Queener SF. Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5- substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase Journal of Medicinal Chemistry. 42: 2272-2279. PMID 10377234 DOI: 10.1021/Jm980586O |
0.421 |
|
| 1999 |
Rosowsky A, Papoulis AT, Forsch RA, Queener SF. Synthesis and antiparasitic and antitumor activity of 2,4-diamino-6- (arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim Journal of Medicinal Chemistry. 42: 1007-1017. PMID 10090784 DOI: 10.1021/Jm980572I |
0.451 |
|
| 1999 |
Tao B, Huang TL, Zhang Q, Jackson L, Queener SF, Donkor IO. Synthesis and anti-Pneumocystis carinii activity of conformationally restricted analogues of pentamidine European Journal of Medicinal Chemistry. 34: 531-538. DOI: 10.1016/S0223-5234(99)80102-0 |
0.404 |
|
| 1999 |
Rosowsky A, Papoulis AT, Queener SF. One-step synthesis of novel 2,4-diaminopyrimidine antifolates from bridged alicyclic ketones and cyanoguanidine Journal of Heterocyclic Chemistry. 36: 723-728. DOI: 10.1002/Jhet.5570360324 |
0.417 |
|
| 1998 |
Gangjee A, Zhu Y, Queener SF. 6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents Journal of Medicinal Chemistry. 41: 4533-4541. PMID 9804692 DOI: 10.1021/Jm980206Z |
0.456 |
|
| 1998 |
Gangjee A, Vidwans AP, Vasudevan A, Queener SF, Kisliuk RL, Cody V, Li R, Galitsky N, Luft JR, Pangborn W. Structure-based design and synthesis of lipophilic 2,4-diamino-6- substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents Journal of Medicinal Chemistry. 41: 3426-3434. PMID 9719595 DOI: 10.1021/Jm980081Y |
0.457 |
|
| 1998 |
Gangjee A, Elzein E, Queener SF, McGuire JJ. Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases Journal of Medicinal Chemistry. 41: 1409-1416. PMID 9554874 DOI: 10.1021/Jm9705420 |
0.454 |
|
| 1998 |
Gangjee A, Guo X, Queener SF, Cody V, Galitsky N, Luft JR, Pangborn W. Selective Pneumocystis carinii dihydrofolate reductase inhibitors: Design, synthesis, and biological evaluation of new 2,4-diamino-5- substituted-furo[2,3-d]pyrimidines Journal of Medicinal Chemistry. 41: 1263-1271. PMID 9548816 DOI: 10.1021/Jm970537W |
0.427 |
|
| 1998 |
Rosowsky A, Papoulis AT, Queener SF. 2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine analogues of trimethoprim as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase Journal of Medicinal Chemistry. 41: 913-918. PMID 9526565 DOI: 10.1021/Jm970614N |
0.415 |
|
| 1997 |
Cody V, Galitsky N, Luft JR, Pangborn W, Gangjee A, Devraj R, Queener SF, Blakley RL. Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate. Acta Crystallographica. Section D, Biological Crystallography. 53: 638-49. PMID 15299851 DOI: 10.1107/S090744499700509X |
0.351 |
|
| 1997 |
Rosowsky A, Papoulis AT, Queener SF. 2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase Journal of Medicinal Chemistry. 40: 3694-3699. PMID 9357537 DOI: 10.1021/Jm970399A |
0.466 |
|
| 1997 |
Robson C, Meek MA, Grunwaldt JD, Lambert PA, Queener SF, Schmidt D, Griffin RJ. Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents. Journal of Medicinal Chemistry. 40: 3040-8. PMID 9301666 DOI: 10.1021/Jm970055K |
0.463 |
|
| 1997 |
Gangjee A, Vasudevan A, Queener SF. Conformationally restricted analogues of trimethoprim: 2,6-diamino-8- substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii Journal of Medicinal Chemistry. 40: 3032-3039. PMID 9301665 DOI: 10.1021/Jm970271T |
0.458 |
|
| 1997 |
Gangjee A, Shi J, Queener SF. Synthesis and biological activities of conformationally restricted, tricyclic nonclassical antifolates as inhibitors of dihydrofolate reductases Journal of Medicinal Chemistry. 40: 1930-1936. PMID 9191971 DOI: 10.1021/Jm960693N |
0.442 |
|
| 1997 |
Stevens MF, Phillip KS, Rathbone DL, O'Shea DM, Queener SF, Schwalbe CH, Lambert PA. Structural studies on bioactive compounds. 28. Selective activity of triazenyl-substituted pyrimethamine derivatives against Pneumocystis carinii dihydrofolate reductase. Journal of Medicinal Chemistry. 40: 1886-93. PMID 9191966 DOI: 10.1021/Jm970050N |
0.413 |
|
| 1997 |
Gangjee A, Vasudevan A, Queener SF. Synthesis and biological evaluation of nonclassical 2,4-diamino-5- methylpyrido[2,3-d]pyrimidines with novel side chain substituents as potential inhibitors of dihydrofolate reductases Journal of Medicinal Chemistry. 40: 479-485. PMID 9046338 DOI: 10.1021/Jm960734F |
0.415 |
|
| 1997 |
Gangjee A, Devraj R, Queener SF. Synthesis and dihydrofolate reductase inhibitory activities of 2,4- diamino-5-deaza and 2,4-diamino-5,10-dideaza lipophilic antifolates Journal of Medicinal Chemistry. 40: 470-478. PMID 9046337 DOI: 10.1021/Jm9606913 |
0.329 |
|
| 1997 |
O'Gara MJ, Lee CH, Weinberg GA, Nott JM, Queener SF. IMP dehydrogenase from Pneumocystis carinii as a potential drug target. Antimicrobial Agents and Chemotherapy. 41: 40-8. PMID 8980752 DOI: 10.1128/Aac.41.1.40 |
0.669 |
|
| 1997 |
Rosowsky A, Forsch RA, Queener SF, Bertino JR. Synthesis of 2,4-diaminopteridines with bulky lipophilic groups at the 6-position as inhibitors of Pneumocystis carinii, Toxoplasma gondii, and mammalian dihydrofolate reductase Pteridines. 8: 173-187. DOI: 10.1515/Pteridines.1997.8.3.173 |
0.465 |
|
| 1996 |
Gangjee A, Mavandadi F, Kisliuk RL, McGuire JJ, Queener SF. 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase Journal of Medicinal Chemistry. 39: 4563-4568. PMID 8917644 DOI: 10.1021/Jm960097T |
0.444 |
|
| 1996 |
Chio LC, Bolyard LA, Nasr M, Queener SF. Identification of a class of sulfonamides highly active against dihydropteroate synthase from Toxoplasma gondii, Pneumocystis carinii, and Mycobacterium avium Antimicrobial Agents and Chemotherapy. 40: 727-733. PMID 8851601 DOI: 10.1128/Aac.40.3.727 |
0.426 |
|
| 1996 |
Bartlett MS, Current WL, Goheen MP, Boylan CJ, Lee CH, Shaw MM, Queener SF, Smith JW. Semisynthetic echinocandins affect cell wall deposition of Pneumocystis carinii in vitro and in vivo. Antimicrobial Agents and Chemotherapy. 40: 1811-6. PMID 8843286 DOI: 10.1128/Aac.40.8.1811 |
0.386 |
|
| 1996 |
Hong YL, Hossler P, Bartlett M, Queener S, Smith J, Meshnick S. Evaluation of sulfa drugs against recombinant Pneumocystis carinii dihydropteroate synthetase and in vivo. The Journal of Eukaryotic Microbiology. 43: 40S. PMID 8822843 DOI: 10.1111/J.1550-7408.1996.Tb04976.X |
0.381 |
|
| 1996 |
Jackson HC, Biggadike K, McKilligin E, Kinsman OS, Queener SF, Lane A, Smith JE. 6,7-disubstituted 2,4-diaminopteridines: Novel inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase Antimicrobial Agents and Chemotherapy. 40: 1371-1375. PMID 8726003 DOI: 10.1128/Aac.40.6.1371 |
0.466 |
|
| 1996 |
Gangjee A, Vasudevan A, Queener SF, Kisliuk RL. 2,4-Diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases Journal of Medicinal Chemistry. 39: 1438-1446. PMID 8691474 DOI: 10.1021/Jm960310L |
0.468 |
|
| 1996 |
Piper JR, Johnson CA, Krauth CA, Carter RL, Hosmer CA, Queener SF, Borotz SE, Pfefferkorn ER. Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations. Journal of Medicinal Chemistry. 39: 1271-80. PMID 8632434 DOI: 10.1021/Jm950760Y |
0.445 |
|
| 1996 |
Gangjee A, Zhu Y, Queener SF, Francom P, Broom AD. Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii Journal of Medicinal Chemistry. 39: 1836-1845. PMID 8627607 DOI: 10.1021/Jm950918E |
0.395 |
|
| 1996 |
Galitsky N, Cody V, Luft JR, Pangborn W, Gangjee A, Queener SF. Comparison ofPneumocystis cariniidihydrofolate reductase inhibitor-cofactor ternary complexes Acta Crystallographica Section a Foundations of Crystallography. 52: C234-C234. DOI: 10.1107/S0108767396090058 |
0.308 |
|
| 1996 |
Delia TJ, Nagarajan A, Queener SF, Bartlet MS. Ring-based analogues of pentamidine versus P. carinii pneumonia in culture Bioorganic and Medicinal Chemistry Letters. 6: 2367-2370. DOI: 10.1016/0960-894X(96)00427-1 |
0.368 |
|
| 1996 |
Huang TL, Zhang Q, White AT, Queener SF, Bartlett MS, Smith JW, Donkor IO. Synthesis and anti-Pneumocystis carinii activity of piperidine-linked aromatic diimidazolines Bioorganic and Medicinal Chemistry Letters. 6: 2087-2090. DOI: 10.1016/0960-894X(96)00373-3 |
0.385 |
|
| 1996 |
Donkor IO, Queener SF, Dalton JT. Pentamidine congeners. 4. DNA binding affinity and anti-Pneumocystis carinii activity of butamidine analogues Bioorganic and Medicinal Chemistry Letters. 6: 1967-1970. DOI: 10.1016/0960-894X(96)00353-8 |
0.325 |
|
| 1996 |
Donkor IO, Devraj R, Queener SF, Barrows LR, Gangjee A. Synthesis of a Series of Diaminobenzo[f]- And Diaminobenzo[h]pyrimido[4,5-b]quinolines as 5-Deaza Tetracyclic Nonclassical Antifolates Journal of Heterocyclic Chemistry. 33: 1653-1660. DOI: 10.1002/Jhet.5570330618 |
0.438 |
|
| 1996 |
Rosowsky A, Mota CE, Queener SF. Brominated trimetrexate analogues as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase Journal of Heterocyclic Chemistry. 33: 1959-1966. |
0.346 |
|
| 1995 |
Hong YL, Bartlett MS, Queener S, Smith JW, Shaw M, Meshnick SR. Pteroylpolyglutamate synthesis by lung- and culture-derived Pneumocystis carinii. Fems Microbiology Letters. 134: 251-4. PMID 8586276 DOI: 10.1111/J.1574-6968.1995.Tb07946.X |
0.331 |
|
| 1995 |
Bartlett MS, Shaw M, Navaran P, Smith JW, Queener SF. Evaluation of potent inhibitors of dihydrofolate reductase in a culture model for growth of Pneumocystis carinii. Antimicrobial Agents and Chemotherapy. 39: 2436-41. PMID 8585722 DOI: 10.1128/Aac.39.11.2436 |
0.465 |
|
| 1995 |
Rosowsky A, Mota CE, Queener SF, Waltham M, Ercikan-Abali E, Bertino JR. 2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii Journal of Medicinal Chemistry. 38: 745-752. PMID 7877140 DOI: 10.1021/Jm00005A002 |
0.407 |
|
| 1995 |
Gangjee A, Mavandadi F, Queener SF, McGuire JJ. Novel 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolate inhibitors of dihydrofolate reductases Journal of Medicinal Chemistry. 38: 2158-2165. PMID 7783147 DOI: 10.1021/Jm00012A016 |
0.471 |
|
| 1995 |
Gangjee A, Vasudevan A, Queener SF, Kisliuk RL. 6-Substituted 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents Journal of Medicinal Chemistry. 38: 1778-1785. PMID 7752201 DOI: 10.1021/Jm00010A022 |
0.467 |
|
| 1995 |
Rosowsky A, Hynes JB, Queener SF. Structure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase Antimicrobial Agents and Chemotherapy. 39: 79-86. PMID 7695334 |
0.34 |
|
| 1995 |
Gangjee A, Zaveri N, Kothare M, Queener SF. Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: synthesis and biological activities. Journal of Medicinal Chemistry. 38: 3660-8. PMID 7658454 DOI: 10.1021/Jm00018A027 |
0.44 |
|
| 1995 |
Rosowsky A, Forsch RA, Queener SF. 2,4-Diaminopyrido[3,2-d]pyrimidine inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii Journal of Medicinal Chemistry. 38: 2615-2620. PMID 7629801 DOI: 10.1021/Jm00014A014 |
0.479 |
|
| 1995 |
Rosowsky A, Mota CE, Queener SF. Synthesis and antifolate activity of 2,4-diamino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine analogues of trimetrexate and piritrexim Journal of Heterocyclic Chemistry. 32: 335-340. DOI: 10.1002/Jhet.5570320155 |
0.47 |
|
| 1995 |
Gangjee A, Zaveri N, Queener SF, Kisliuk RL. Synthesis and biological activities of tetrahydroquinazoline analogs of aminopterin and methotrexate Journal of Heterocyclic Chemistry. 32: 243-247. DOI: 10.1002/Jhet.5570320141 |
0.427 |
|
| 1994 |
Gangjee A, Devraj R, McGuire JJ, Kisliuk RL, Queener SF, Barrows LR. Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: Synthesis and biological activities Journal of Medicinal Chemistry. 37: 1169-1176. PMID 8164259 DOI: 10.1021/Jm00034A015 |
0.489 |
|
| 1994 |
Bartlett MS, Queener SF, Shaw MM, Richardson JD, Smith JW. Pneumocystis carinii is resistant to imidazole antifungal agents. Antimicrobial Agents and Chemotherapy. 38: 1859-61. PMID 7986021 DOI: 10.1128/Aac.38.8.1859 |
0.354 |
|
| 1994 |
Lu JJ, Bartlett MS, Shaw MM, Queener SF, Smith JW, Ortiz-Rivera M, Leibowitz MJ, Lee CH. Typing of Pneumocystis carinii strains that infect humans based on nucleotide sequence variations of internal transcribed spacers of rRNA genes. Journal of Clinical Microbiology. 32: 2904-12. PMID 7883876 DOI: 10.1128/Jcm.32.12.2904-2912.1994 |
0.328 |
|
| 1994 |
PAULSRUD JR, QUEENER SF. Incorporation of Fatty Acids and Amino Acids by Cultured Pneumocystis carinii Journal of Eukaryotic Microbiology. 41: 633-638. PMID 7866387 DOI: 10.1111/J.1550-7408.1994.Tb01525.X |
0.344 |
|
| 1994 |
Rosowsky A, Mota CE, Wright JE, Queener SF. 2,4-Diamino-5-chloroquinazoline analogues of trimetrexate and piritrexim: synthesis and antifolate activity. Journal of Medicinal Chemistry. 37: 4522-8. PMID 7799402 DOI: 10.1021/Jm00052A011 |
0.448 |
|
| 1993 |
Gangjee A, Vasudevan A, Queener SF. Bicyclic conformationally restricted analogs of nonclassical pyrido[2,3- d] pyrimidines as potential inhibitors of dihydrofolate reductases Advances in Experimental Medicine and Biology. 338: 449-452. PMID 8304156 DOI: 10.1007/978-1-4615-2960-6_90 |
0.41 |
|
| 1993 |
Gangjee A, Devraj R, Queener SF, Kisliuk RL. Novel 2,4-diamino-5-substituted furo[2,3-d]-pyrimidines as potential antifolates Advances in Experimental Medicine and Biology. 338: 445-448. PMID 8304155 DOI: 10.1007/978-1-4615-2960-6_89 |
0.388 |
|
| 1993 |
Gangjee A, Mavandadi F, Queener SF. Synthesis and biological activity of tricyclic, conformationally restricted analogs of lipophilic pyrido[2,3-d]-pyrimidine antifolates Advances in Experimental Medicine and Biology. 338: 441-444. PMID 8304154 DOI: 10.1007/978-1-4615-2960-6_88 |
0.449 |
|
| 1993 |
Queener SF, Bartlett MS, Nasr M, Smith JW. 8-aminoquinolines effective against Pneumocystis carinii in vitro and in vivo. Antimicrobial Agents and Chemotherapy. 37: 2166-72. PMID 8257140 DOI: 10.1128/Aac.37.10.2166 |
0.395 |
|
| 1993 |
Chio LC, Queener SF. Identification of highly potent and selective inhibitors of Toxoplasma gondii dihydrofolate reductase Antimicrobial Agents and Chemotherapy. 37: 1914-1923. PMID 8239605 DOI: 10.1128/Aac.37.9.1914 |
0.432 |
|
| 1993 |
Gangjee A, Shi J, Queener SF, Barrows LR, Kisliuk RL. Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents Journal of Medicinal Chemistry®. 36: 3437-3443. PMID 8230134 DOI: 10.1021/Jm00074A026 |
0.422 |
|
| 1993 |
Rosowsky A, Mota CE, Wright JE, Freisheim JH, Heusner JJ, McCormack JJ, Queener SF. 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase Journal of Medicinal Chemistry. 36: 3103-3112. PMID 8230096 DOI: 10.1021/Jm00073A009 |
0.429 |
|
| 1992 |
Bartlett MS, Edlind TD, Durkin MM, Shaw MM, Queener SF, Smith JW. Antimicrotubule benzimidazoles inhibit in vitro growth of Pneumocystis carinii. Antimicrobial Agents and Chemotherapy. 36: 779-82. PMID 1503439 DOI: 10.1128/Aac.36.4.779 |
0.391 |
|
| 1992 |
Durkin MM, Bartlett MS, Queener SF, Shaw MM, Lee CH, Smith JW. An enzyme-linked immunosorbent assay for enumeration of Pneumocystis carinii in vitro and in vivo. Journal of Clinical Microbiology. 30: 3258-62. PMID 1452712 DOI: 10.1128/Jcm.30.12.3258-3262.1992 |
0.349 |
|
| 1991 |
Queener SF, Fujioka H, Nishiyama Y, Furukawa H, Bartlett MS, Smith JW. In vitro activities of acridone alkaloids against Pneumocystis carinii Antimicrobial Agents and Chemotherapy. 35: 377-379. PMID 2024971 DOI: 10.1128/Aac.35.2.377 |
0.389 |
|
| 1991 |
Broughton MC, Queener SF. Pneumocystis carinii dihydrofolate reductase used to screen potential antipneumocystis drugs. Antimicrobial Agents and Chemotherapy. 35: 1348-55. PMID 1929292 DOI: 10.1128/Aac.35.7.1348 |
0.478 |
|
| 1991 |
Queener SF. Inhibition of Pneumocystis dihydrofolate reductase by analogs of pyrimethamine, methotrexate and trimetrexate Journal of Protozoology. 38. PMID 1840146 |
0.323 |
|
| 1989 |
Rosowsky A, Freisheim JH, Hynes JB, Queener SF, Bartlett M, Smith JW, Lazarus H, Modest EJ. Tricyclic 2,4-diaminopyrimidines with broad antifolate activity and the ability to inhibit pneumocystis carinii growth in cultured human lung fibroblasts in the presence of leucovorin Biochemical Pharmacology. 38: 2677-2684. PMID 2788420 DOI: 10.1016/0006-2952(89)90554-6 |
0.413 |
|
| 1987 |
Smith JW, Bartlett MS, Queener SF, Durkin MM, Jay MA, Hull MT, Klein RS, Marr JJ. Pneumocystis carinii pneumonia therapy with 9-deazainosine in rats. Diagnostic Microbiology and Infectious Disease. 7: 113-8. PMID 3498606 DOI: 10.1016/0732-8893(87)90028-9 |
0.313 |
|
| 1987 |
Bartlett MS, Queener SF, Jay MA, Durkin MM, Smith JW. Improved rat model for studying Pneumocystis carinii pneumonia Journal of Clinical Microbiology. 25: 480-484. PMID 2952669 DOI: 10.1128/Jcm.25.3.480-484.1987 |
0.302 |
|
| 1987 |
Queener SF, Bartlett MS, Jay MA, Durkin MM, Smith JW. Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection Antimicrobial Agents and Chemotherapy. 31: 1323-1327. PMID 2445281 DOI: 10.1128/Aac.31.9.1323 |
0.391 |
|
| 1971 |
Weber G, Queener SF, Ferdinandus JA. Control of gene expression in carbohydrate, pyrimidine and DNA metabolism Advances in Enzyme Regulation. 9: 63-95. PMID 4329198 DOI: 10.1016/S0065-2571(71)80038-9 |
0.338 |
|
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