Edward A. Botchwey, Ph.D. - Publications

Affiliations: 
2002 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biomedical Engineering, Cell Biology

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 DeVeaux SA, Ogle ME, Vyshnya S, Chiappa NF, Leitmann B, Rudy R, Day A, Mortensen LJ, Kurtzberg J, Roy K, Botchwey EA. Characterizing human mesenchymal stromal cells' immune-modulatory potency using targeted lipidomic profiling of sphingolipids. Cytotherapy. PMID 35190267 DOI: 10.1016/j.jcyt.2021.12.009  0.315
2021 Medrano-Trochez C, Chatterjee P, Pradhan P, Stevens HY, Ogle ME, Botchwey EA, Kurtzberg J, Yeago C, Gibson G, Roy K. Single-cell RNA-seq of out-of-thaw mesenchymal stromal cells shows tissue-of-origin differences and inter-donor cell-cycle variations. Stem Cell Research & Therapy. 12: 565. PMID 34736534 DOI: 10.1186/s13287-021-02627-9  0.31
2021 Selma JM, Song H, Rivera C, Douglas SA, Akella A, Bollavaram K, Thompson N, Platt MO, Botchwey EA. Sickle cell disease promotes sex-dependent pathological bone loss through enhanced cathepsin proteolytic activity. Blood Advances. PMID 34547771 DOI: 10.1182/bloodadvances.2021004615  0.301
2020 Hymel LA, Ogle ME, Anderson SE, San Emeterio CL, Turner TC, York WY, Liu AY, Olingy CE, Sridhar S, Lim HS, Sulchek T, Qiu P, Jang YC, Willett NJ, Botchwey EA. Modulating local S1P Receptor signaling as a regenerative immunotherapy after volumetric muscle loss injury. Journal of Biomedical Materials Research. Part A. PMID 32608188 DOI: 10.1002/Jbm.A.37053  0.348
2020 Clark AY, Martin KE, García JR, Johnson CT, Theriault HS, Han WM, Zhou DW, Botchwey EA, García AJ. Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities. Nature Communications. 11: 114. PMID 31913286 DOI: 10.1038/S41467-019-14000-9  0.463
2019 Johnson CT, Sok MCP, Martin KE, Kalelkar PP, Caplin JD, Botchwey EA, García AJ. Lysostaphin and BMP-2 co-delivery reduces infection and regenerates critical-sized segmental bone defects. Science Advances. 5: eaaw1228. PMID 31114804 DOI: 10.1126/Sciadv.Aaw1228  0.374
2019 Ballestas SA, Turner TC, Kamalakar A, Stephenson YC, Willett NJ, Goudy SL, Botchwey EA. Improving hard palate wound healing using immune modulatory autotherapies. Acta Biomaterialia. PMID 31029828 DOI: 10.1016/J.Actbio.2019.04.052  0.326
2018 Krieger JR, Sok MCP, Turner TC, Botchwey EA. Delivery of Immunomodulatory Microparticles in a Murine Model of Rotator Cuff Tear. Mrs Advances. 3: 1341-1346. PMID 30002922 DOI: 10.1557/Adv.2018.50  0.35
2018 Selma JM, Das A, Awojoodu AO, Wang T, Kaushik AP, Cui Q, Song H, Ogle ME, Olingy CE, Pendleton EG, Tehrani KF, Mortensen LJ, Botchwey EA. Novel Lipid Signaling Mediators for Mesenchymal Stem Cell Mobilization during Bone Repair. Cellular and Molecular Bioengineering. 11: 241-253. PMID 29983824 DOI: 10.1007/S12195-018-0532-0  0.433
2018 Ogle ME, Krieger JR, Tellier LE, McFaline-Figueroa J, Temenoff JS, Botchwey EA. Dual Affinity Heparin-Based Hydrogels Achieve Pro-Regenerative Immunomodulation and Microvascular Remodeling. Acs Biomaterials Science & Engineering. 4: 1241-1250. PMID 29682605 DOI: 10.1021/Acsbiomaterials.6B00706  0.365
2017 Enam SF, Krieger JR, Saxena T, Watts BE, Olingy CE, Botchwey EA, Bellamkonda RV. Enrichment of endogenous fractalkine and anti-inflammatory cells via aptamer-functionalized hydrogels. Biomaterials. 142: 52-61. PMID 28727998 DOI: 10.1016/J.Biomaterials.2017.07.013  0.359
2017 Olingy CE, San Emeterio CL, Ogle ME, Krieger JR, Bruce AC, Pfau DD, Jordan BT, Peirce SM, Botchwey EA. Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury. Scientific Reports. 7: 447. PMID 28348370 DOI: 10.1038/S41598-017-00477-1  0.37
2017 Bowers DT, Olingy CE, Chhabra P, Langman L, Merrill PH, Linhart RS, Tanes ML, Lin D, Brayman KL, Botchwey EA. An engineered macroencapsulation membrane releasing FTY720 to precondition pancreatic islet transplantation. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. PMID 28240814 DOI: 10.1002/Jbm.B.33862  0.332
2017 Sok MC, Tria MC, Olingy CE, San Emeterio CL, Botchwey EA. Aspirin-triggered resolvin D1-modified materials promote the accumulation of pro-regenerative immune cell subsets and enhance vascular remodeling. Acta Biomaterialia. PMID 28213094 DOI: 10.1016/J.Actbio.2017.02.020  0.412
2016 Ogle ME, Olingy CE, Awojoodu AO, Das A, Ortiz RA, Cheung HY, Botchwey EA. Sphingosine-1-phosphate Receptor-3 Supports Hematopoietic Stem and Progenitor Cell Residence within the Bone Marrow Niche. Stem Cells (Dayton, Ohio). PMID 28026131 DOI: 10.1002/Stem.2556  0.418
2016 San Emeterio CL, Olingy CE, Chu Y, Botchwey EA. Selective recruitment of non-classical monocytes promotes skeletal muscle repair. Biomaterials. 117: 32-43. PMID 27930948 DOI: 10.1016/J.Biomaterials.2016.11.021  0.334
2016 Bush JR, Liang H, Dickinson M, Botchwey EA. Xylan hemicellulose improves chitosan hydrogel for bone tissue regeneration. Polymers For Advanced Technologies. 27: 1050-1055. PMID 27587941 DOI: 10.1002/Pat.3767  0.443
2016 Ogle ME, Segar CE, Sridhar S, Botchwey EA. Monocytes and macrophages in tissue repair: Implications for immunoregenerative biomaterial design. Experimental Biology and Medicine (Maywood, N.J.). 241: 1084-97. PMID 27229903 DOI: 10.1177/1535370216650293  0.426
2016 Bush JR, Liang H, Dickinson M, Botchwey EA. Xylan hemicellulose improves chitosan hydrogel for bone tissue regeneration Polymers For Advanced Technologies. DOI: 10.1002/pat.3767  0.393
2015 Krieger JR, Ogle ME, McFaline-Figueroa J, Segar CE, Temenoff JS, Botchwey EA. Spatially localized recruitment of anti-inflammatory monocytes by SDF-1α-releasing hydrogels enhances microvascular network remodeling. Biomaterials. 77: 280-290. PMID 26613543 DOI: 10.1016/J.Biomaterials.2015.10.045  0.386
2015 Bowers DT, Botchwey EA, Brayman KL. Advances in Local Drug Release and Scaffolding Design to Enhance Cell Therapy for Diabetes. Tissue Engineering. Part B, Reviews. PMID 26192271 DOI: 10.1089/Ten.Teb.2015.0275  0.345
2015 Wang T, Krieger J, Huang C, Das A, Francis MP, Ogle R, Botchwey E. Enhanced osseous integration of human trabecular allografts following surface modification with bioactive lipids. Drug Delivery and Translational Research. PMID 26169381 DOI: 10.1007/S13346-015-0244-0  0.447
2015 Das A, Segar CE, Chu Y, Wang TW, Lin Y, Yang C, Du X, Ogle RC, Cui Q, Botchwey EA. Bioactive lipid coating of bone allografts directs engraftment and fate determination of bone marrow-derived cells in rat GFP chimeras. Biomaterials. 64: 98-107. PMID 26125501 DOI: 10.1016/J.Biomaterials.2015.06.019  0.462
2015 Das A, Lenz SM, Awojoodu AO, Botchwey EA. Abluminal stimulation of sphingosine 1-phosphate receptors 1 and 3 promotes and stabilizes endothelial sprout formation. Tissue Engineering. Part A. 21: 202-13. PMID 25315888 DOI: 10.1089/Ten.Tea.2013.0744  0.308
2014 Bowers DT, Tanes ML, Das A, Lin Y, Keane NA, Neal RA, Ogle ME, Brayman KL, Fraser CL, Botchwey EA. Spatiotemporal oxygen sensing using dual emissive boron dye-polylactide nanofibers. Acs Nano. 8: 12080-91. PMID 25426706 DOI: 10.1021/Nn504332J  0.322
2014 Ogle ME, Sefcik LS, Awojoodu AO, Chiappa NF, Lynch K, Peirce-Cottler S, Botchwey EA. Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning. Acta Biomaterialia. 10: 4704-14. PMID 25128750 DOI: 10.1016/J.Actbio.2014.08.007  0.412
2014 Das A, Barker DA, Wang T, Lau CM, Lin Y, Botchwey EA. Delivery of bioactive lipids from composite microgel-microsphere injectable scaffolds enhances stem cell recruitment and skeletal repair. Plos One. 9: e101276. PMID 25077607 DOI: 10.1371/Journal.Pone.0101276  0.468
2014 Awojoodu AO, Keegan PM, Lane AR, Zhang Y, Lynch KR, Platt MO, Botchwey EA. Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD. Blood. 124: 1941-50. PMID 25075126 DOI: 10.1182/Blood-2014-01-543652  0.35
2014 Das A, Tanner S, Barker DA, Green D, Botchwey EA. Delivery of S1P receptor-targeted drugs via biodegradable polymer scaffolds enhances bone regeneration in a critical size cranial defect. Journal of Biomedical Materials Research. Part A. 102: 1210-8. PMID 23640833 DOI: 10.1002/Jbm.A.34779  0.479
2013 Das A, Segar CE, Hughley BB, Bowers DT, Botchwey EA. The promotion of mandibular defect healing by the targeting of S1P receptors and the recruitment of alternatively activated macrophages. Biomaterials. 34: 9853-62. PMID 24064148 DOI: 10.1016/J.Biomaterials.2013.08.015  0.489
2013 Barker DA, Bowers DT, Hughley B, Chance EW, Klembczyk KJ, Brayman KL, Park SS, Botchwey EA. Multilayer cell-seeded polymer nanofiber constructs for soft-tissue reconstruction. Jama Otolaryngology-- Head & Neck Surgery. 139: 914-22. PMID 24051747 DOI: 10.1001/Jamaoto.2013.4119  0.467
2013 Awojoodu AO, Ogle ME, Sefcik LS, Bowers DT, Martin K, Brayman KL, Lynch KR, Peirce-Cottler SM, Botchwey E. Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 13785-90. PMID 23918395 DOI: 10.1073/Pnas.1221309110  0.385
2013 Segar CE, Ogle ME, Botchwey EA. Regulation of angiogenesis and bone regeneration with natural and synthetic small molecules. Current Pharmaceutical Design. 19: 3403-19. PMID 23432670 DOI: 10.2174/1381612811319190007  0.454
2012 Ray BJ, Thomas K, Huang CS, Gutknecht MF, Botchwey EA, Bouton AH. Regulation of osteoclast structure and function by FAK family kinases. Journal of Leukocyte Biology. 92: 1021-8. PMID 22941736 DOI: 10.1189/Jlb.0512259  0.313
2012 Huang C, Das A, Barker D, Tholpady S, Wang T, Cui Q, Ogle R, Botchwey E. Local delivery of FTY720 accelerates cranial allograft incorporation and bone formation Cell and Tissue Research. 347: 553-566. PMID 21863314 DOI: 10.1007/S00441-011-1217-3  0.47
2011 Das A, Botchwey E. Evaluation of Angiogenesis and Osteogenesis Tissue Engineering Part B-Reviews. 17: 403-414. PMID 21902609 DOI: 10.1089/Ten.Teb.2011.0190  0.495
2011 Cui Q, Botchwey EA. Emerging ideas: treatment of precollapse osteonecrosis using stem cells and growth factors. Clinical Orthopaedics and Related Research. 469: 2665-9. PMID 21161735 DOI: 10.1007/S11999-010-1738-1  0.386
2011 Sefcik LS, Aronin CE, Awojoodu AO, Shin SJ, Mac Gabhann F, MacDonald TL, Wamhoff BR, Lynch KR, Peirce SM, Botchwey EA. Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth. Tissue Engineering. Part A. 17: 617-29. PMID 20874260 DOI: 10.1089/Ten.Tea.2010.0404  0.336
2011 Cui Q, Botchwey EA. Emerging ideas: Treatment of precollapse osteonecrosis using stem cells and growth factors Clinical Orthopaedics and Related Research. 469: 2665-2669. DOI: 10.1007/s11999-010-1738-1  0.366
2010 Petrie Aronin CE, Shin SJ, Naden KB, Rios PD, Sefcik LS, Zawodny SR, Bagayoko ND, Cui Q, Khan Y, Botchwey EA. The enhancement of bone allograft incorporation by the local delivery of the sphingosine 1-phosphate receptor targeted drug FTY720 Biomaterials. 31: 6417-6424. PMID 20621764 DOI: 10.1016/J.Biomaterials.2010.04.061  0.429
2010 Petrie Aronin CE, Sefcik LS, Tholpady SS, Tholpady A, Sadik KW, Macdonald TL, Peirce SM, Wamhoff BR, Lynch KR, Ogle RC, Botchwey EA. FTY720 promotes local microvascular network formation and regeneration of cranial bone defects. Tissue Engineering. Part A. 16: 1801-9. PMID 20038198 DOI: 10.1089/Ten.Tea.2009.0539  0.451
2010 Pritchard CD, Arnér KM, Neal RA, Neeley WL, Bojo P, Bachelder E, Holz J, Watson N, Botchwey EA, Langer RS, Ghosh FK. The use of surface modified poly(glycerol-co-sebacic acid) in retinal transplantation. Biomaterials. 31: 2153-62. PMID 19962754 DOI: 10.1016/J.Biomaterials.2009.11.074  0.431
2009 Neal RA, Oredein-McCoy O, Botchwey EA. Nanomedicine: Addressing Cardiovascular Disease and Cardiovascular Tissue Regeneration. Current Bioactive Compounds. 5: 206-214. PMID 27630537 DOI: 10.2174/157340709789054722  0.334
2009 Nickerson MM, Song J, Shuptrine CW, Wieghaus KA, Botchwey EA, Price RJ. Influence of poly(D,L-lactic-co-glycolic acid) microsphere degradation on arteriolar remodeling in the mouse dorsal skinfold window chamber. Journal of Biomedical Materials Research. Part A. 91: 317-23. PMID 18980190 DOI: 10.1002/Jbm.A.32209  0.354
2009 Neal RA, McClugage SG, Link MC, Sefcik LS, Ogle RC, Botchwey EA. Laminin nanofiber meshes that mimic morphological properties and bioactivity of basement membranes. Tissue Engineering. Part C, Methods. 15: 11-21. PMID 18844601 DOI: 10.1089/Ten.Tec.2007.0366  0.423
2009 Petrie Aronin CE, Sadik KW, Lay AL, Rion DB, Tholpady SS, Ogle RC, Botchwey EA. Comparative effects of scaffold pore size, pore volume, and total void volume on cranial bone healing patterns using microsphere-based scaffolds. Journal of Biomedical Materials Research. Part A. 89: 632-41. PMID 18442122 DOI: 10.1002/Jbm.A.32015  0.454
2008 Sefcik LS, Petrie Aronin CE, Botchwey EA. Engineering vascularized tissues using natural and synthetic small molecules. Organogenesis. 4: 215-27. PMID 19337401 DOI: 10.4161/Org.4.4.6963  0.327
2008 Wieghaus KA, Nickerson MM, Petrie Aronin CE, Sefcik LS, Price RJ, Paige MA, Brown ML, Botchwey EA. Expansion of microvascular networks in vivo by phthalimide neovascular factor 1 (PNF1). Biomaterials. 29: 4698-708. PMID 18804278 DOI: 10.1016/J.Biomaterials.2008.08.029  0.394
2008 Sefcik LS, Neal RA, Kaszuba SN, Parker AM, Katz AJ, Ogle RC, Botchwey EA. Collagen nanofibres are a biomimetic substrate for the serum-free osteogenic differentiation of human adipose stem cells. Journal of Tissue Engineering and Regenerative Medicine. 2: 210-20. PMID 18493910 DOI: 10.1002/Term.85  0.437
2008 Petrie Aronin CE, Cooper JA, Sefcik LS, Tholpady SS, Ogle RC, Botchwey EA. Osteogenic differentiation of dura mater stem cells cultured in vitro on three-dimensional porous scaffolds of poly(epsilon-caprolactone) fabricated via co-extrusion and gas foaming. Acta Biomaterialia. 4: 1187-97. PMID 18434267 DOI: 10.1016/J.Actbio.2008.02.029  0.475
2008 Sefcik LS, Petrie Aronin CE, Wieghaus KA, Botchwey EA. Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering. Biomaterials. 29: 2869-77. PMID 18405965 DOI: 10.1016/J.Biomaterials.2008.03.017  0.498
2008 Petrie C, Tholpady S, Ogle R, Botchwey E. Proliferative capacity and osteogenic potential of novel dura mater stem cells on poly-lactic-co-glycolic acid. Journal of Biomedical Materials Research. Part A. 85: 61-71. PMID 17688255 DOI: 10.1002/Jbm.A.31367  0.528
2007 Wieghaus KA, Gianchandani EP, Brown ML, Papin JA, Botchwey EA. Mechanistic exploration of phthalimide neovascular factor 1 using network analysis tools. Tissue Engineering. 13: 2561-75. PMID 17723106 DOI: 10.1089/Ten.2007.0023  0.301
2006 Wieghaus KA, Capitosti SM, Anderson CR, Price RJ, Blackman BR, Brown ML, Botchwey EA. Small molecule inducers of angiogenesis for tissue engineering. Tissue Engineering. 12: 1903-13. PMID 16889520 DOI: 10.1089/Ten.2006.12.1903  0.431
2006 Laurencin CT, Khan Y, Kofron M, El-Amin S, Botchwey E, Yu X, Cooper JA. The ABJS Nicolas Andry Award: Tissue engineering of bone and ligament: a 15-year perspective. Clinical Orthopaedics and Related Research. 447: 221-36. PMID 16741478 DOI: 10.1097/01.blo.0000194677.02506.45  0.636
2006 El-Amin SF, Botchwey E, Tuli R, Kofron MD, Mesfin A, Sethuraman S, Tuan RS, Laurencin CT. Human osteoblast cells: isolation, characterization, and growth on polymers for musculoskeletal tissue engineering. Journal of Biomedical Materials Research. Part A. 76: 439-49. PMID 16541483 DOI: 10.1002/Jbm.A.30411  0.616
2006 Botchwey E, Ferrante E, Humphrey J. Bioreactor-based bone tissue engineering Journal of Biomechanics. 39: S218. DOI: 10.1016/S0021-9290(06)83800-5  0.383
2005 Wieghaus KA, Capitosti SM, Brown ML, Botchwey EA. Novel angiogenic compounds for targeted drug delivery Materials Research Society Symposium Proceedings. 845: 357-361. DOI: 10.1557/Proc-845-Aa5.47  0.477
2004 Yu X, Botchwey EA, Levine EM, Pollack SR, Laurencin CT. Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization. Proceedings of the National Academy of Sciences of the United States of America. 101: 11203-8. PMID 15277663 DOI: 10.1073/Pnas.0402532101  0.662
2004 Botchwey EA, Pollack SR, Levine EM, Johnston ED, Laurencin CT. Quantitative analysis of three-dimensional fluid flow in rotating bioreactors for tissue engineering. Journal of Biomedical Materials Research. Part A. 69: 205-15. PMID 15057993 DOI: 10.1002/Jbm.A.10163  0.617
2004 Yu X, Botchwey EA, Levine EM, Pollack SR, Laurencin CT. Bioreactor Based Bone Tissue Engineering: Influence of Wall Collision on Osteoblast Cultured on Polymeric Microcarrier Scaffolds in Rotating Bioreactors Mrs Proceedings. 845. DOI: 10.1557/Proc-845-Aa5.38  0.679
2003 Botchwey EA, Dupree MA, Pollack SR, Levine EM, Laurencin CT. Tissue engineered bone: measurement of nutrient transport in three-dimensional matrices. Journal of Biomedical Materials Research. Part A. 67: 357-67. PMID 14517896 DOI: 10.1002/Jbm.A.10111  0.633
2003 Botchwey EA, Pollack SR, El-Amin S, Levine EM, Tuan RS, Laurencin CT. Human osteoblast-like cells in three-dimensional culture with fluid flow. Biorheology. 40: 299-306. PMID 12454419  0.581
2001 Botchwey EA, Pollack SR, Levine EM, Laurencin CT. Bone tissue engineering in a rotating bioreactor using a microcarrier matrix system. Journal of Biomedical Materials Research. 55: 242-53. PMID 11255176 DOI: 10.1002/1097-4636(200105)55:2<242::Aid-Jbm1011>3.0.Co;2-D  0.657
1998 Laurencin C, Attawia M, Botchwey E, Warren R, Attia E. Cell-material systems for anterior cruciate ligament regeneration. In Vitro Cellular & Developmental Biology – Animal. 34: 90-92. PMID 9542643 DOI: 10.1007/S11626-998-0088-8  0.434
1996 Attawia MA, Uhrich KE, Botchwey E, Langer R, Laurencin CT. In vitro bone biocompatibility of poly(anhydride-co-imides) containing pyromellitylimidoalanine Journal of Orthopaedic Research. 14: 445-454. PMID 8676258 DOI: 10.1002/Jor.1100140315  0.645
1995 Attawia MA, Uhrich KE, Botchwey E, Fan M, Langer R, Laurencin CT. Cytotoxicity testing of poly(anhydride-co-imides) for orthopedic applications Journal of Biomedical Materials Research. 29: 1233-1240. PMID 8557725 DOI: 10.1002/Jbm.820291010  0.612
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