Kelley R. Healey, Ph.D. - Publications

Affiliations: 
2013 Drexel University College of Medicine, Philadelphia, PA, United States 
Area:
Microbiology Biology, Molecular Biology, Pharmacology

23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Healey KR, Singh A. Heterologous Expression of Candida Antifungal Target Genes in the Model Organism Saccharomyces cerevisiae. Methods in Molecular Biology (Clifton, N.J.). 2658: 181-190. PMID 37024702 DOI: 10.1007/978-1-0716-3155-3_12  0.316
2022 Yu S, Paderu P, Lee A, Eirekat S, Healey K, Chen L, Perlin DS, Zhao Y. Histone Acetylation Regulator Gcn5 Mediates Drug Resistance and Virulence of Candida glabrata. Microbiology Spectrum. e0096322. PMID 35658596 DOI: 10.1128/spectrum.00963-22  0.4
2021 Williamson B, Wilk A, Guerrero KD, Mikulski TD, Elias TN, Sawh I, Cancino-Prado G, Gardam D, Heath CH, Govender NP, Perlin DS, Kordalewska M, Healey KR. Impact of Erg11 amino acid substitutions identified in clade III isolates on triazole drug susceptibility. Antimicrobial Agents and Chemotherapy. AAC0162421. PMID 34633842 DOI: 10.1128/AAC.01624-21  0.359
2021 Garcia-Rubio R, Hernandez RY, Clear A, Healey KR, Shor E, Perlin DS. Critical Assessment of Cell Wall Integrity Factors Contributing to Echinocandin Tolerance and Resistance in . Frontiers in Microbiology. 12: 702779. PMID 34305871 DOI: 10.3389/fmicb.2021.702779  0.48
2020 Healey KR, Paderu P, Hou X, Jimenez Ortigosa C, Bagley N, Patel B, Zhao Y, Perlin DS. Differential Regulation of Echinocandin Targets Fks1 and Fks2 in by the Post-Transcriptional Regulator Ssd1. Journal of Fungi (Basel, Switzerland). 6. PMID 32825653 DOI: 10.3390/Jof6030143  0.54
2019 Hou X, Healey KR, Shor E, Kordalewska M, Ortigosa CJ, Paderu P, Xiao M, Wang H, Zhao Y, Lin LY, Zhang YH, Li YZ, Xu YC, Perlin DS, Zhao Y. Novel and modifications in a high-level echinocandin resistant clinical isolate of . Emerging Microbes & Infections. 8: 1619-1625. PMID 31711370 DOI: 10.1080/22221751.2019.1684209  0.563
2018 Shields RK, Kline EG, Healey KR, Kordalewska M, Perlin DS, Nguyen MH, Clancy CJ. Spontaneous mutational frequency and mutation rates vary by echinocandin agent against . Antimicrobial Agents and Chemotherapy. PMID 30373796 DOI: 10.1128/AAC.01692-18  0.423
2018 Healey KR, Perlin DS. Fungal Resistance to Echinocandins and the MDR Phenomenon in . Journal of Fungi (Basel, Switzerland). 4. PMID 30200517 DOI: 10.3390/Jof4030105  0.487
2018 Healey KR, Kordalewska M, Jiménez Ortigosa C, Singh A, Berrío I, Chowdhary A, Perlin DS. Limited mutations identified in isolates of directly contribute to reduced azole susceptibility. Antimicrobial Agents and Chemotherapy. PMID 30082281 DOI: 10.1128/Aac.01427-18  0.461
2018 Byun SA, Won EJ, Kim MN, Lee WG, Lee K, Lee HS, Uh Y, Healey KR, Perlin DS, Choi MJ, Kim SH, Shin JH. Multilocus Sequence Typing (MLST) Genotypes of Bloodstream Isolates in Korea: Association With Antifungal Resistance, Mutations in Mismatch Repair Gene (Msh2), and Clinical Outcomes. Frontiers in Microbiology. 9: 1523. PMID 30057573 DOI: 10.3389/fmicb.2018.01523  0.47
2018 Taj-Aldeen SJ, Salah H, Perez WB, Almaslamani M, Motyl M, AbdulWahab A, Healey KR, Perlin DS. Molecular analysis of resistance and detection of non-wild type strains using ECV values of Etest for amphotericin B and echinocandins for bloodstream infections from a tertiary hospital in Qatar. Antimicrobial Agents and Chemotherapy. PMID 29941644 DOI: 10.1128/Aac.00214-18  0.525
2018 Break TJ, Desai JV, Healey KR, Natarajan M, Ferre EMN, Henderson C, Zelazny A, Siebenlist U, Yates CM, Cohen OJ, Schotzinger RJ, Perlin DS, Garvey EP, Lionakis MS. VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice. The Journal of Antimicrobial Chemotherapy. PMID 29788070 DOI: 10.1093/jac/dky170  0.346
2018 Singh A, Healey KR, Yadav P, Upadhyaya G, Sachdeva N, Sarma S, Kumar A, Tarai B, Perlin DS, Chowdhary A. Absence of azole or echinocandin resistance inisolates in India despite background prevalence of strains with defects in DNA mismatch repair pathway. Antimicrobial Agents and Chemotherapy. PMID 29610199 DOI: 10.1128/Aac.00195-18  0.603
2017 Healey KR, Nagasaki Y, Zimmerman M, Kordalewska M, Park S, Zhao Y, Perlin DS. The gastrointestinal tract is a major source of echinocandin drug resistance in a murine model of Candida glabrata colonization and systemic dissemination. Antimicrobial Agents and Chemotherapy. PMID 28971865 DOI: 10.1128/Aac.01412-17  0.496
2017 Healey K, Zhao Y, Nagasaki Y, Park S, Perlin D. The Gastrointestinal Tract Is a Major Source of Echinocandin Drug Resistance in a Candida glabrata Colonization Mouse Model Open Forum Infectious Diseases. 4: S129-S129. DOI: 10.1093/Ofid/Ofx163.180  0.378
2016 Dellière S, Healey K, Gits-Muselli M, Carrara B, Barbaro A, Guigue N, Lecefel C, Touratier S, Desnos-Ollivier M, Perlin DS, Bretagne S, Alanio A. Fluconazole and Echinocandin Resistance of Correlates Better with Antifungal Drug Exposure Rather than with Mutator Genotype in a French Cohort of Patients Harboring Low Rates of Resistance. Frontiers in Microbiology. 7: 2038. PMID 28066361 DOI: 10.3389/Fmicb.2016.02038  0.566
2016 Healey KR, Jimenez Ortigosa C, Shor E, Perlin DS. Genetic Drivers of Multidrug Resistance in Candida glabrata. Frontiers in Microbiology. 7: 1995. PMID 28018323 DOI: 10.3389/Fmicb.2016.01995  0.553
2016 Healey KR, Zhao Y, Perez WB, Lockhart SR, Sobel JD, Farmakiotis D, Kontoyiannis DP, Sanglard D, Taj-Aldeen SJ, Alexander BD, Jimenez-Ortigosa C, Shor E, Perlin DS. Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance. Nature Communications. 7: 11128. PMID 27020939 DOI: 10.1038/Ncomms11128  0.562
2016 Katiyar S, Shiffrin E, Shelton C, Healey K, Vermitsky JP, Edlind T. Evaluation of Polymorphic Locus Sequence Typing for Candida glabrata Epidemiology. Journal of Clinical Microbiology. PMID 26842706 DOI: 10.1128/Jcm.03106-15  0.589
2015 Healey KR, Challa KK, Edlind TD, Katiyar SK. Sphingolipids mediate differential echinocandin susceptibility in Candida albicans and Aspergillus nidulans. Antimicrobial Agents and Chemotherapy. 59: 3377-84. PMID 25824222 DOI: 10.1128/Aac.04667-14  0.618
2012 Katiyar SK, Alastruey-Izquierdo A, Healey KR, Johnson ME, Perlin DS, Edlind TD. Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata: implications for echinocandin resistance. Antimicrobial Agents and Chemotherapy. 56: 6304-9. PMID 23027185 DOI: 10.1128/Aac.00813-12  0.662
2012 Healey KR, Katiyar SK, Raj S, Edlind TD. CRS-MIS in Candida glabrata: sphingolipids modulate echinocandin-Fks interaction. Molecular Microbiology. 86: 303-13. PMID 22909030 DOI: 10.1111/J.1365-2958.2012.08194.X  0.61
2011 Healey KR, Katiyar SK, Castanheira M, Pfaller MA, Edlind TD. Candida glabrata mutants demonstrating paradoxical reduced caspofungin susceptibility but increased micafungin susceptibility. Antimicrobial Agents and Chemotherapy. 55: 3947-9. PMID 21628537 DOI: 10.1128/Aac.00044-11  0.66
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