| Year |
Citation |
Score |
| 2020 |
Pierson EE, Midey AJ, Forrest WP, Shah V, Olivos HJ, Shrestha B, Teller R, Forster S, Bensussan A, Helmy R. Direct Drug Analysis in Polymeric Implants Using Desorption Electrospray Ionization - Mass Spectrometry Imaging (DESI-MSI). Pharmaceutical Research. 37: 107. PMID 32462273 DOI: 10.1007/S11095-020-02823-X |
0.313 |
|
| 2020 |
Rudd ND, Helmy R, Dormer PG, Williamson RT, Wuelfing WP, Walsh PL, Reibarkh M, Forrest WP. Probing Release Kinetics of Long-Acting Injectable Nanosuspensions Flow-NMR Spectroscopy. Molecular Pharmaceutics. PMID 31895571 DOI: 10.1021/Acs.Molpharmaceut.9B00958 |
0.336 |
|
| 2019 |
Yang RS, Zhang LK, Helmy R, Andreani T, Liu Z, Sheng H. Development of a highly efficient decontamination approach for ceftolozane in the pharmaceutical manufacturing environment. Journal of Pharmaceutical and Biomedical Analysis. 177: 112846. PMID 31522097 DOI: 10.1016/J.Jpba.2019.112846 |
0.3 |
|
| 2018 |
Nanda KK, Mozziconacci O, Small J, Allain LR, Helmy R, Wuelfing WP. Enrichment of Relevant Oxidative Degradation Products in Pharmaceuticals with Targeted Chemoselective Oxidation. Journal of Pharmaceutical Sciences. PMID 30395830 DOI: 10.1016/J.Xphs.2018.10.059 |
0.301 |
|
| 2018 |
Salter R, Beshore DC, Colletti SL, Evans L, Gong Y, Helmy R, Liu Y, Maciolek CM, Martin G, Pajkovic N, Phipps R, Small J, Steele J, de Vries R, Williams H, et al. Microbial Biotransformation - An Important Tool for the Study of Drug Metabolism. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-38. PMID 30118378 DOI: 10.1080/00498254.2018.1512018 |
0.32 |
|
| 2018 |
Li Y, Liu Y, Gao H, Helmy R, Wuelfing WP, Welch C, Cooks RG. Accelerated Forced Degradation of Pharmaceuticals in Levitated Microdroplet Reactors. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29653016 DOI: 10.1002/Chem.201801176 |
0.361 |
|
| 2017 |
Pu F, Zhang W, Bateman KP, Liu Y, Helmy R, Ouyang Z. Using miniature MS system with automatic blood sampler for preclinical pharmacokinetics study. Bioanalysis. PMID 29095035 DOI: 10.4155/Bio-2017-0160 |
0.344 |
|
| 2017 |
Forrest WP, Mackey MA, Shah VM, Hassell KM, Shah P, Wylie JL, Gopinath J, Balderhaar H, Li L, Wuelfing WP, Helmy R. Mixed Reality (MR) Meets Pharmaceutical Development. Journal of Pharmaceutical Sciences. PMID 28870539 DOI: 10.1016/J.Xphs.2017.08.020 |
0.303 |
|
| 2017 |
Sheng H, Lexa KW, Zhang LK, Yang RS, Wright TJ, Sherry BD, Helmy R, Martin GE. Unusual (+/-)-Electrospray Ionization Induced Fragmentation: Structural Elucidation of an In-process Synthetic Intermediate of Doravirine (MK-1439) Using LC/HRMS/MS and 2D-NMR. Rapid Communications in Mass Spectrometry : Rcm. PMID 28171682 DOI: 10.1002/Rcm.7833 |
0.315 |
|
| 2017 |
Yang RS, Sheng H, Lexa KW, Sherer EC, Zhang LK, Xiang B, Helmy R, Mao B. Mechanistic Study of the Gas-Phase In-Source Hofmann Elimination of Doubly Quaternized Cinchona-Alkaloid Based Phase-Transfer Catalysts by (+)-Electrospray Ionization/Tandem Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 28101849 DOI: 10.1007/S13361-016-1583-X |
0.321 |
|
| 2017 |
Tan Z, Liu Y, Helmy R, Rivera NR, Hesk D, Tyagarajan S, Yang L, Su J. Electrochemical bromination of late stage intermediates and drug molecules Tetrahedron Letters. 58: 3014-3018. DOI: 10.1016/J.Tetlet.2017.06.019 |
0.332 |
|
| 2017 |
Yao H, Liu Y, Tyagarajan S, Streckfuss E, Reibarkh M, Chen K, Zamora I, Fontaine F, Goracci L, Helmy R, Bateman KP, Krska SW. Enabling Efficient Late-Stage Functionalization of Drug-Like Molecules with LC-MS and Reaction-Driven Data Processing European Journal of Organic Chemistry. 2017: 7122-7126. DOI: 10.1002/Ejoc.201701573 |
0.323 |
|
| 2016 |
Zhang LK, Yang R, Sheng H, Helmy R, Zheng J, Cao Y, Gauthier DR. Characterization of Impurities of HIV NNRTI Doravirine by UHPLC-High Resolution MS and Tandem MS Analysis. Journal of Mass Spectrometry : Jms. PMID 27383410 DOI: 10.1002/Jms.3807 |
0.356 |
|
| 2016 |
Marques R, Waterhouse DJ, Helmy R. Moisture determination of tritium tracers utilizing near-infrared spectroscopy. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 27061331 DOI: 10.1002/Jlcr.3394 |
0.33 |
|
| 2016 |
Zhang T, Liu Y, Yang X, Martin GE, Yao H, Shang J, Bugianesi RM, Ellsworth KP, Sonatore LM, Nizner P, Sherer EC, Hill SE, Knemeyer IW, Geissler WM, Dandliker PJ, ... Helmy R, et al. Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program. Journal of Medicinal Chemistry. PMID 26871940 DOI: 10.1021/Acs.Jmedchem.5B01293 |
0.306 |
|
| 2016 |
Gao J, Ceglia SS, Jones MD, Simeone J, Antwerp JV, Zhang LK, Ross CW, Helmy R. A novel compact mass detection platform for the open access (OA) environment in drug discovery and early development. Journal of Pharmaceutical and Biomedical Analysis. 122: 1-8. PMID 26821286 DOI: 10.1016/J.Jpba.2016.01.017 |
0.355 |
|
| 2015 |
Zheng Q, Liu Y, Chen Q, Hu M, Helmy R, Sherer EC, Welch CJ, Chen H. Capture of Reactive Monophosphine-Ligated Palladium(0) Intermediates by Mass Spectrometry. Journal of the American Chemical Society. PMID 26498505 DOI: 10.1021/Jacs.5B08905 |
0.301 |
|
| 2015 |
Cai Y, Zheng Q, Liu Y, Helmy R, Loo JA, Chen H. Integration of electrochemistry with ultra-performance liquid chromatography/mass spectrometry. European Journal of Mass Spectrometry (Chichester, England). 21: 341-51. PMID 26307715 DOI: 10.1255/Ejms.1318 |
0.339 |
|
| 2015 |
Lu M, Liu Y, Helmy R, Martin GE, Dewald HD, Chen H. Online Investigation of Aqueous-Phase Electrochemical Reactions by Desorption Electrospray Ionization Mass Spectrometry. Journal of the American Society For Mass Spectrometry. 26: 1676-85. PMID 26242804 DOI: 10.1007/S13361-015-1210-2 |
0.347 |
|
| 2015 |
Marques R, Helmy R, Waterhouse D. Enhancing radiolytic stability upon concentration of tritium-labeled pharmaceuticals utilizing centrifugal evaporation. Journal of Labelled Compounds & Radiopharmaceuticals. 58: 261-3. PMID 25964076 DOI: 10.1002/Jlcr.3292 |
0.354 |
|
| 2015 |
Truong V, Helmy R, Ren S, Schenk D, Waterhouse D. Application of HPLC mixed-mode chromatography in determining radiochemical purity of [(14) C] labeled metformin hydrochloride. Journal of Labelled Compounds & Radiopharmaceuticals. 58: 177-9. PMID 25720824 DOI: 10.1002/Jlcr.3264 |
0.353 |
|
| 2015 |
Makarov AA, Schafer WA, Helmy R. Use of pressure in reversed-phase liquid chromatography to study protein conformational changes by differential deuterium exchange. Analytical Chemistry. 87: 2396-402. PMID 25620238 DOI: 10.1021/Ac5043494 |
0.303 |
|
| 2015 |
Buitrago Santanilla A, Regalado EL, Pereira T, Shevlin M, Bateman K, Campeau LC, Schneeweis J, Berritt S, Shi ZC, Nantermet P, Liu Y, Helmy R, Welch CJ, Vachal P, Davies IW, et al. Organic chemistry. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules. Science (New York, N.Y.). 347: 49-53. PMID 25554781 DOI: 10.1126/Science.1259203 |
0.355 |
|
| 2015 |
Yang R, Beard A, Sheng H, Zhang L, Helmy R. Applications of TiCl3 as a Diagnostic Reagent for the Detection of Nitro- and N-Oxide-Containing Compounds as Potentially Mutagenic Impurities Using Ultrahigh-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry Organic Process Research & Development. 20: 59-64. DOI: 10.1021/Acs.Oprd.5B00312 |
0.386 |
|
| 2014 |
Cai Y, Liu Y, Helmy R, Chen H. Coupling of ultrafast LC with mass spectrometry by DESI. Journal of the American Society For Mass Spectrometry. 25: 1820-3. PMID 25023648 DOI: 10.1007/S13361-014-0954-4 |
0.354 |
|
| 2014 |
Regalado EL, Helmy R, Green MD, Welch CJ. Chromatographic resolution of closely related species: drug metabolites and analogs. Journal of Separation Science. 37: 1094-102. PMID 24596023 DOI: 10.1002/Jssc.201400038 |
0.36 |
|
| 2014 |
Marques R, Bernardoni F, Pollack S, Helmy R. Development of an automated system for preparation of liquid scintillation counting samples for radiolabeled pharmaceuticals. Journal of Labelled Compounds & Radiopharmaceuticals. 57: 121-4. PMID 24327404 DOI: 10.1002/Jlcr.3156 |
0.688 |
|
| 2014 |
Al-Sayah MA, Liu Y, Helmy R, Yehl P. Using Oxidation–Reduction Chemistry in Sample Preparation for Sub-PPM Quantitation by LC/MS Journal of Liquid Chromatography & Related Technologies. 38: 729-732. DOI: 10.1080/10826076.2014.962150 |
0.345 |
|
| 2014 |
Liu Y, Green MD, Marques R, Pereira T, Helmy R, Thomas Williamson R, Bermel W, Martin GE. Using pure shift HSQC to characterize microgram samples of drug metabolites Tetrahedron Letters. 55: 5450-5453. DOI: 10.1016/J.Tetlet.2014.06.067 |
0.323 |
|
| 2013 |
Yang J, Leopold P, Helmy R, Parish C, Arvary B, Mao B, Meng F. Design and application of an easy to use oligonucleotide mass calculation program. Journal of the American Society For Mass Spectrometry. 24: 1315-8. PMID 23740032 DOI: 10.1007/S13361-013-0643-8 |
0.332 |
|
| 2013 |
Wang H, Nardi R, Bereznitski Y, Helmy R, Waterhouse DJ. Quantitation of Genetox Impurities Using a Surrogate Standard Approach Journal of Analytical Sciences, Methods and Instrumentation. 3: 167-172. DOI: 10.4236/Jasmi.2013.33021 |
0.355 |
|
| 2013 |
Lee C, Zang J, Cuff J, McGachy N, Natishan TK, Welch CJ, Helmy R, Bernardoni F. Application of Heart-Cutting 2D-LC for the Determination of Peak Purity for a Chiral Pharmaceutical Compound by HPLC Chromatographia. 76: 5-11. DOI: 10.1007/S10337-012-2367-5 |
0.312 |
|
| 2010 |
Helmy R, Schafer W, Buhler L, Marcinko S, Musselman B, Guidry E, Jenkins H, Fleitz F, Welch CJ. Ambient pressure desorption ionization mass spectrometry in support of preclinical pharmaceutical development Organic Process Research and Development. 14: 386-392. DOI: 10.1021/Op9002938 |
0.378 |
|
| 2010 |
Lee C, Helmy R, Strulson C, Plewa J, Kolodziej E, Antonucci V, Mao B, Welch CJ, Ge Z, Al-Sayah MA. Removal of electrophilic potential genotoxic impurities using nucleophilic reactive resins Organic Process Research and Development. 14: 1021-1026. DOI: 10.1021/Op1000397 |
0.338 |
|
| 2010 |
Welch CJ, Wu N, Biba M, Hartman R, Brkovic T, Gong X, Helmy R, Schafer W, Cuff J, Pirzada Z, Zhou L. Greening analytical chromatography Trac - Trends in Analytical Chemistry. 29: 667-680. DOI: 10.1016/J.Trac.2010.03.008 |
0.317 |
|
| 2009 |
Bernardoni F, Sajonz P, Zang J, Lee C, Marcinko S, Abrahim A, Helmy R. Looking Beyond the Column: An Investigation into Method Irreproducibility for an Active Pharmaceutical Ingredient Chromatographia. 70: 1561-1567. DOI: 10.1365/S10337-009-1381-8 |
0.302 |
|
| 2008 |
Peresypkin A, Variankaval N, Ferlita R, Wenslow R, Smitrovich J, Thompson K, Murry J, Crocker L, Mathre D, Wang J, Harmon P, Ellison M, Song S, Makarov A, Helmy R. Discovery of a stable molecular complex of an API with HCl: a long journey to a conventional salt. Journal of Pharmaceutical Sciences. 97: 3721-6. PMID 18240276 DOI: 10.1002/Jps.21264 |
0.331 |
|
| 2008 |
Price K, Clausen AM, Helmy R. Effect of injection diluent on a chiral separation on an amylose S-α-methylbenzylcarbamate chiral stationary phase (short communication) Journal of Liquid Chromatography and Related Technologies. 31: 2286-2295. DOI: 10.1080/10826070802281612 |
0.3 |
|
| 2006 |
Sajonz P, Vailaya A, Sudah O, McPherson L, Capodanno V, Natishan TK, Helmy R, Antia FD. Development of a gradient elution preparative high performance liquid chromatography method for the recovery of the antibiotic ertapenem from crystallization process streams. Journal of Chromatography. A. 1126: 365-72. PMID 16735042 DOI: 10.1016/J.Chroma.2006.04.077 |
0.346 |
|
| 2005 |
Wang P, Shi YJ, Helmy R, Reamer R, Vailaya A. Identification of a trace colored impurity in drug substance by preparative liquid chromatography and mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 19: 3749-54. PMID 16308847 DOI: 10.1002/Rcm.2261 |
0.356 |
|
| 2005 |
Helmy R, Kazakevich Y, Ni C, Fadeev AY. Wetting in hydrophobic nanochannels: a challenge of classical capillarity. Journal of the American Chemical Society. 127: 12446-7. PMID 16144365 DOI: 10.1021/Ja053267C |
0.596 |
|
| 2005 |
Vailaya A, Sajonz P, Sudah O, Capodanno V, Helmy R, Antia FD. Exploiting pH mismatch in preparative high-performance liquid chromatographic recovery of ertapenem from mother liquor streams. Journal of Chromatography. A. 1079: 80-91. PMID 16038294 DOI: 10.1016/J.Chroma.2005.04.004 |
0.33 |
|
| 2005 |
McElwee J, Helmy R, Fadeev AY. Thermal stability of organic monolayers chemically grafted to minerals. Journal of Colloid and Interface Science. 285: 551-6. PMID 15837471 DOI: 10.1016/J.Jcis.2004.12.006 |
0.637 |
|
| 2005 |
McElwee J, Helmy R, Fadeev AY. Thermal stability of organic monolayers chemically grafted to minerals Journal of Colloid and Interface Science. 285: 551-556. DOI: 10.1016/j.jcis.2004.12.006 |
0.611 |
|
| 2004 |
Helmy R, Wenslow RW, Fadeev AY. Reaction of organosilicon hydrides with solid surfaces: an example of surface-catalyzed self-assembly. Journal of the American Chemical Society. 126: 7595-600. PMID 15198607 DOI: 10.1021/Ja0498336 |
0.62 |
|
| 2002 |
Chen Y, Wang T, Helmy R, Zhou GX, LoBrutto R. Concentration determination of methyl magnesium chloride and other Grignard reagents by potentiometric titration with in-line characterization of reaction species by FTIR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis. 29: 393-404. PMID 12062641 DOI: 10.1016/S0731-7085(02)00079-1 |
0.332 |
|
| 2002 |
Fadeev AY, Helmy R, Marcinko S. Self-Assembled Monolayers of Organosilicon Hydrides Supported on Titanium, Zirconium, and Hafnium Dioxides Langmuir. 18: 7521-7529. DOI: 10.1021/La020178U |
0.619 |
|
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