| Year |
Citation |
Score |
| 2020 |
Gupta R, Liu Y, Wang H, Nordyke CT, Puterbaugh RZ, Cui W, Varga K, Chu F, Ke H, Vashisth H, Cote RH. Structural Analysis of the Regulatory GAF Domains of cGMP Phosphodiesterase Elucidates the Allosteric Communication Pathway. Journal of Molecular Biology. PMID 32898583 DOI: 10.1016/J.Jmb.2020.08.026 |
0.629 |
|
| 2020 |
Li X, Gu C, Hostachy S, Sahu S, Wittwer C, Jessen HJ, Fiedler D, Wang H, Shears SB. Control of XPR1-dependent cellular phosphate efflux by InsP is an exemplar for functionally-exclusive inositol pyrophosphate signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 32019887 DOI: 10.1073/Pnas.1908830117 |
0.332 |
|
| 2019 |
Randall TA, Gu C, Li X, Wang H, Shears SB. A two-way switch for inositol pyrophosphate signaling: Evolutionary history and biological significance of a unique, bifunctional kinase/phosphatase. Advances in Biological Regulation. 100674. PMID 31776069 DOI: 10.1016/J.Jbior.2019.100674 |
0.327 |
|
| 2019 |
Riley AM, Wang H, Shears SB, Potter BVL. Synthesis of an α-phosphono-α,α-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP. Medchemcomm. 10: 1165-1172. PMID 31391889 DOI: 10.1039/C9Md00163H |
0.343 |
|
| 2019 |
An Y, Jessen HJ, Wang H, Shears SB, Kireev D. Dynamics of Substrate Processing by PPIP5K2, a Versatile Catalytic Machine. Structure (London, England : 1993). PMID 30956131 DOI: 10.1016/J.Str.2019.03.007 |
0.335 |
|
| 2019 |
Gu C, Stashko MA, Puhl-Rubio A, Chakraborty M, Chakraborty A, Frye SV, Pearce KH, Wang X, Shears SB, Wang H. Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure/Activity Analysis. Journal of Medicinal Chemistry. PMID 30624931 DOI: 10.2210/Pdb6M8D/Pdb |
0.386 |
|
| 2018 |
Shears SB, Wang H. Inositol phosphate kinases: Expanding the biological significance of the universal core of the protein kinase fold. Advances in Biological Regulation. PMID 30392847 DOI: 10.1016/J.Jbior.2018.10.006 |
0.39 |
|
| 2018 |
Yao T, Huang Y, Zhang M, Chen Y, Pei H, Shi J, Wang H, Wang Y, Ke H. Crystal structures of Candida albicans phosphodiesterase-2 and implication on its biological functions. Biochemistry. PMID 30231198 DOI: 10.1021/Acs.Biochem.8B00707 |
0.65 |
|
| 2018 |
Feng X, Wang H, Ye M, Xu XT, Xu Y, Yang W, Zhang H, Song G, Ke H. Identification of a PDE4-specific pocket for design of selective inhibitors. Biochemistry. PMID 29975048 DOI: 10.1021/Acs.Biochem.8B00336 |
0.644 |
|
| 2018 |
Wang H, Gu C, Rolfes RJ, Jessen HJ, Shears SB. Structural and biochemical characterization of Siw14: a protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates. The Journal of Biological Chemistry. PMID 29540476 DOI: 10.1074/Jbc.Ra117.001670 |
0.402 |
|
| 2018 |
Nair VS, Gu C, Janoshazi AK, Jessen HJ, Wang H, Shears SB. Inositol Pyrophosphate Synthesis by Diphosphoinositol Pentakisphosphate Kinase-1 is Regulated by Phosphatidylinositol(4,5)bisphosphate. Bioscience Reports. PMID 29459425 DOI: 10.1042/Bsr20171549 |
0.382 |
|
| 2018 |
Wang H, Shears SB, Gu C, Rolfes RJ, Jessen HJ. Structural resolution of Siw14: a protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates. Journal of Biological Chemistry. DOI: 10.2210/Pdb6Byf/Pdb |
0.301 |
|
| 2017 |
Gu C, Nguyen HN, Ganini D, Chen Z, Jessen HJ, Gu Z, Wang H, Shears SB. KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078269 DOI: 10.1073/Pnas.1702370114 |
0.31 |
|
| 2017 |
Rajasekaran SS, Illies C, Shears SB, Wang H, Ayala TS, Martins JO, Daré E, Berggren PO, Barker CJ. Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity. Cellular Signalling. PMID 29042286 DOI: 10.1016/J.Cellsig.2017.10.008 |
0.333 |
|
| 2017 |
Wang H, Shears SB. Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities. The Journal of Biological Chemistry. PMID 28882892 DOI: 10.1074/Jbc.M117.801845 |
0.372 |
|
| 2017 |
Gu C, Nguyen HN, Hofer A, Jessen HJ, Dai X, Wang H, Shears SB. The Significance of the Bifunctional Kinase/Phosphatase Activities of PPIP5Ks for Coupling Inositol Pyrophosphate Cell-Signaling to Cellular Phosphate Homeostasis. The Journal of Biological Chemistry. PMID 28126903 DOI: 10.1074/Jbc.M116.765743 |
0.324 |
|
| 2016 |
Shears SB, Baughman BM, Gu C, Nair VS, Wang H. The significance of the 1-kinase/1-phosphatase activities of the PPIP5K family. Advances in Biological Regulation. PMID 27776974 DOI: 10.1016/J.Jbior.2016.10.003 |
0.327 |
|
| 2016 |
Baughman BM, Wang H, An Y, Kireev D, Stashko MA, Jessen HJ, Pearce KH, Frye SV, Shears SB. A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors. Plos One. 11: e0164378. PMID 27736936 DOI: 10.1371/Journal.Pone.0164378 |
0.362 |
|
| 2016 |
Hager A, Wu M, Wang H, Brown NW, Shears SB, Veiga N, Fiedler D. Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27460418 DOI: 10.1002/Chem.201601754 |
0.321 |
|
| 2016 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Aparin A, Arkhipkin D, Aschenauer EC, Attri A, Averichev GS, Bai X, Bairathi V, Banerjee A, Bellwied R, ... Wang H, et al. Measurement of the Transverse Single-Spin Asymmetry in p^{↑}+p→W^{±}/Z^{0} at RHIC. Physical Review Letters. 116: 132301. PMID 27081970 DOI: 10.1103/Physrevlett.116.132301 |
0.545 |
|
| 2016 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Aparin A, Arkhipkin D, Aschenauer EC, Attri A, Averichev GS, Bai X, Bairathi V, Bellwied R, Bhasin A, ... ... Wang H, et al. Beam Energy Dependence of the Third Harmonic of Azimuthal Correlations in Au+Au Collisions at RHIC. Physical Review Letters. 116: 112302. PMID 27035295 DOI: 10.1103/Physrevlett.116.112302 |
0.556 |
|
| 2016 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Bairathi V, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... ... Wang H, et al. Centrality and Transverse Momentum Dependence of Elliptic Flow of Multistrange Hadrons and ϕ Meson in Au+Au Collisions at sqrt[s_{NN}]=200 GeV. Physical Review Letters. 116: 062301. PMID 26918982 DOI: 10.1103/Physrevlett.116.062301 |
0.572 |
|
| 2015 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... ... Wang H, et al. Observation of Transverse Spin-Dependent Azimuthal Correlations of Charged Pion Pairs in p^{↑}+p at sqrt[s]=200 GeV. Physical Review Letters. 115: 242501. PMID 26705627 DOI: 10.1103/Physrevlett.115.242501 |
0.546 |
|
| 2015 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... ... Wang H, et al. Azimuthal Anisotropy in U+U and Au+Au Collisions at RHIC. Physical Review Letters. 115: 222301. PMID 26650297 DOI: 10.1103/Physrevlett.115.222301 |
0.56 |
|
| 2015 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Wang H, et al. Precision Measurement of the Longitudinal Double-Spin Asymmetry for Inclusive Jet Production in Polarized Proton Collisions at sqrt[s]=200 GeV. Physical Review Letters. 115: 092002. PMID 26371644 DOI: 10.1103/Physrevlett.115.092002 |
0.532 |
|
| 2015 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... ... Wang H, et al. Observation of Charge Asymmetry Dependence of Pion Elliptic Flow and the Possible Chiral Magnetic Wave in Heavy-Ion Collisions. Physical Review Letters. 114: 252302. PMID 26197122 DOI: 10.1103/Physrevlett.114.252302 |
0.546 |
|
| 2015 |
Riley AM, Wang H, Shears SB, L Potter BV. Synthetic tools for studying the chemical biology of InsP8. Chemical Communications (Cambridge, England). 51: 12605-8. PMID 26153667 DOI: 10.1039/C5Cc05017K |
0.301 |
|
| 2015 |
Li J, Wang H, Ke H, Ni S. MiR-129 regulates MMP9 to control metastasis of non-small cell lung cancer. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. 36: 5785-90. PMID 25716201 DOI: 10.1007/s13277-015-3247-z |
0.51 |
|
| 2015 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Wang H, et al. ΛΛ Correlation function in Au+Au collisions at √[S(NN)]=200 GeV. Physical Review Letters. 114: 022301. PMID 25635541 DOI: 10.1103/Physrevlett.114.022301 |
0.546 |
|
| 2015 |
Chen XH, Liu ZC, Zhang G, Wei W, Wang XX, Wang H, Ke HP, Zhang F, Wang HS, Cai SH, Du J. TGF-β and EGF induced HLA-I downregulation is associated with epithelial-mesenchymal transition (EMT) through upregulation of snail in prostate cancer cells. Molecular Immunology. 65: 34-42. PMID 25618241 DOI: 10.1016/J.Molimm.2014.12.017 |
0.486 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Wang H, et al. Observation of D0 meson nuclear modifications in Au+Au collisions at sqrt[s(NN)] = 200 GeV. Physical Review Letters. 113: 142301. PMID 25325635 DOI: 10.1103/Physrevlett.113.142301 |
0.553 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Balewski J, Banerjee A, Barnovska Z, ... ... Wang H, et al. Beam energy dependence of moments of the net-charge multiplicity distributions in Au+Au collisions at RHIC. Physical Review Letters. 113: 092301. PMID 25215979 DOI: 10.1103/Physrevlett.113.092301 |
0.542 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Balewski J, Banerjee A, Beavis DR, ... ... Wang H, et al. Measurement of longitudinal spin asymmetries for weak boson production in polarized proton-proton collisions at RHIC. Physical Review Letters. 113: 072301. PMID 25170701 DOI: 10.1103/Physrevlett.113.072301 |
0.535 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Wang H, et al. Beam-energy dependence of charge separation along the magnetic field in Au+Au collisions at RHIC. Physical Review Letters. 113: 052302. PMID 25126911 DOI: 10.1103/Physrevlett.113.052302 |
0.552 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Barnovska Z, Beavis DR, ... ... Wang H, et al. Dielectron mass spectra from Au+Au collisions at √[s(NN)]=200 GeV. Physical Review Letters. 113: 022301. PMID 25062167 DOI: 10.1103/Physrevlett.113.022301 |
0.551 |
|
| 2014 |
Capolicchio S, Wang H, Thakor DT, Shears SB, Jessen HJ. Synthesis of densely phosphorylated bis-1,5-diphospho-myo-inositol tetrakisphosphate and its enantiomer by bidirectional P-anhydride formation. Angewandte Chemie (International Ed. in English). 53: 9508-11. PMID 25044992 DOI: 10.1002/Anie.201404398 |
0.31 |
|
| 2014 |
Wang H, DeRose EF, London RE, Shears SB. IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family. Nature Communications. 5: 4178. PMID 24956979 DOI: 10.1038/Ncomms5178 |
0.396 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Wang H, et al. Beam-energy dependence of the directed flow of protons, antiprotons, and pions in Au+Au collisions. Physical Review Letters. 112: 162301. PMID 24815640 DOI: 10.1103/Physrevlett.112.162301 |
0.558 |
|
| 2014 |
Wang H, Godage HY, Riley AM, Weaver JD, Shears SB, Potter BV. Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery. Chemistry & Biology. 21: 689-99. PMID 24768307 DOI: 10.1016/J.Chembiol.2014.03.009 |
0.353 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Beavis DR, Bellwied R, ... ... Wang H, et al. Jet-hadron correlations in √[s(NN)]=200 GeV p+p and central Au+Au collisions. Physical Review Letters. 112: 122301. PMID 24724645 DOI: 10.1103/Physrevlett.112.122301 |
0.55 |
|
| 2014 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Balewski J, Banerjee A, Barnovska Z, ... ... Wang H, et al. Energy dependence of moments of net-proton multiplicity distributions at RHIC. Physical Review Letters. 112: 032302. PMID 24484135 DOI: 10.1103/Physrevlett.112.032302 |
0.556 |
|
| 2013 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer E, Averichev GS, Balewski J, Banerjee A, Barnovska Z, ... ... Wang H, et al. Observation of an energy-dependent difference in elliptic flow between particles and antiparticles in relativistic heavy ion collisions. Physical Review Letters. 110: 142301. PMID 25166982 DOI: 10.1103/Physrevlett.110.142301 |
0.542 |
|
| 2013 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer E, Averichev GS, Balewski J, Banerjee A, Barnovska Z, ... ... Wang H, et al. Measurement of J/ψ azimuthal anisotropy in Au+Au collisions at sqrt[s(NN)]=200 GeV. Physical Review Letters. 111: 052301. PMID 23952389 DOI: 10.1103/Physrevlett.111.052301 |
0.551 |
|
| 2013 |
Jansen C, Wang H, Kooistra AJ, de Graaf C, Orrling KM, Tenor H, Seebeck T, Bailey D, de Esch IJ, Ke H, Leurs R. Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure. Journal of Medicinal Chemistry. 56: 2087-96. PMID 23409953 DOI: 10.1021/Jm3017877 |
0.635 |
|
| 2013 |
Wang H, Ke H, Lin SY, Guo Y, Zhao L, Tang J, Li YH. Heterometallic octanuclear RE(III)3Ni(II)5 (RE = Dy(III), Gd(III) and Y(III)) clusters with slow magnetic relaxation for the dysprosium derivative. Dalton Transactions (Cambridge, England : 2003). 42: 5298-303. PMID 23403627 DOI: 10.1039/c3dt32572e |
0.517 |
|
| 2013 |
Weaver JD, Wang H, Shears SB. The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment. Bioscience Reports. 33: e00022. PMID 23240582 DOI: 10.1042/Bsr20120115 |
0.335 |
|
| 2013 |
Shears SB, Weaver JD, Wang H. Structural insight into inositol pyrophosphate turnover. Advances in Biological Regulation. 53: 19-27. PMID 23107997 DOI: 10.1016/J.Jbior.2012.10.002 |
0.341 |
|
| 2012 |
Riley AM, Wang H, Weaver JD, Shears SB, Potter BV. First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase. Chemical Communications (Cambridge, England). 48: 11292-4. PMID 23032903 DOI: 10.1039/C2Cc36044F |
0.353 |
|
| 2012 |
Adamczyk L, Agakishiev G, Aggarwal MM, Ahammed Z, Alakhverdyants AV, Alekseev I, Alford J, Anderson BD, Anson CD, Arkhipkin D, Averichev GS, Balewski J, Banerjee A, Barnovska Z, Beavis DR, ... ... Wang H, et al. Directed flow of identified particles in Au+Au collisions at √[SNN]=200 GeV at RHIC. Physical Review Letters. 108: 202301. PMID 23003142 DOI: 10.1103/Physrevlett.108.202301 |
0.555 |
|
| 2012 |
Chen HL, Chen YC, Lu MY, Chang JJ, Wang HT, Ke HM, Wang TY, Ruan SK, Wang TY, Hung KY, Cho HY, Lin WT, Shih MC, Li WH. A highly efficient β-glucosidase from the buffalo rumen fungus Neocallimastix patriciarum W5. Biotechnology For Biofuels. 5: 24. PMID 22515264 DOI: 10.1186/1754-6834-5-24 |
0.546 |
|
| 2012 |
Agakishiev G, Aggarwal MM, Ahammed Z, Alakhverdyants AV, Alekseev I, Alford J, Anderson BD, Anson CD, Arkhipkin D, Averichev GS, Balewski J, Barnby LS, Beavis DR, Bellwied R, Betancourt MJ, ... ... Wang H, et al. Identified hadron compositions in p+p and Au+Au collisions at high transverse momenta at √S(NN)=200 GeV. Physical Review Letters. 108: 072302. PMID 22401197 DOI: 10.1103/Physrevlett.108.072302 |
0.532 |
|
| 2012 |
Agakishiev G, Aggarwal MM, Ahammed Z, Alakhverdyants AV, Alekseev I, Alford J, Anderson BD, Anson CD, Arkhipkin D, Averichev GS, Balewski J, Barnby LS, Beavis DR, Behera NK, Bellwied R, ... ... Wang H, et al. Strangeness enhancement in Cu-Cu and Au-Au collisions at √S(NN)=200 GeV. Physical Review Letters. 108: 072301. PMID 22401196 DOI: 10.1103/Physrevlett.108.072301 |
0.516 |
|
| 2012 |
Wang H, Kunz S, Chen G, Seebeck T, Wan Y, Robinson H, Martinelli S, Ke H. Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors. The Journal of Biological Chemistry. 287: 11788-97. PMID 22356915 DOI: 10.1074/Jbc.M111.326777 |
0.659 |
|
| 2012 |
Wang H, Falck JR, Hall TM, Shears SB. Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nature Chemical Biology. 8: 111-6. PMID 22119861 DOI: 10.1038/Nchembio.733 |
0.357 |
|
| 2011 |
Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, Cai Y, Norberg HV, Zhang T, Furuya T, Jin M, Zhu Z, Wang H, Yu J, Li Y, et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell. 147: 223-34. PMID 21962518 DOI: 10.1016/J.Cell.2011.08.037 |
0.605 |
|
| 2011 |
Chou YH, Li CC, Hsu H, Chang WC, Liu CC, Li WM, Ke HL, Lee MH, Liu ME, Pan SC, Wang HS. Renal function in patients with urinary stones of varying compositions. The Kaohsiung Journal of Medical Sciences. 27: 264-7. PMID 21757143 DOI: 10.1016/j.kjms.2010.11.008 |
0.483 |
|
| 2011 |
Ke H, Wang H, Ye M. Structural insight into the substrate specificity of phosphodiesterases. Handbook of Experimental Pharmacology. 121-34. PMID 21695637 DOI: 10.1007/978-3-642-17969-3_4 |
0.646 |
|
| 2010 |
Wang H, Robinson H, Ke H. Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain. The Journal of Biological Chemistry. 285: 38149-56. PMID 20861010 DOI: 10.1074/Jbc.M110.141614 |
0.618 |
|
| 2010 |
Zhang J, Sapienza PJ, Ke H, Chang A, Hengel SR, Wang H, Phillips GN, Lee AL. Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E. Biochemistry. 49: 9280-91. PMID 20839809 DOI: 10.1021/Bi101131F |
0.633 |
|
| 2010 |
Wang H, Luo X, Ye M, Hou J, Robinson H, Ke H. Insight into binding of phosphodiesterase-9A selective inhibitors by crystal structures and mutagenesis. Journal of Medicinal Chemistry. 53: 1726-31. PMID 20121115 DOI: 10.1021/Jm901519F |
0.643 |
|
| 2009 |
Norris RP, Ratzan WJ, Freudzon M, Mehlmann LM, Krall J, Movsesian MA, Wang H, Ke H, Nikolaev VO, Jaffe LA. Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte. Development (Cambridge, England). 136: 1869-78. PMID 19429786 DOI: 10.1242/Dev.035238 |
0.565 |
|
| 2009 |
Castaño T, Wang H, Campillo NE, Ballester S, González-García C, Hernández J, Pérez C, Cuenca J, Pérez-Castillo A, Martínez A, Huertas O, Gelpí JL, Luque FJ, Ke H, Gil C. Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors. Chemmedchem. 4: 866-76. PMID 19350606 DOI: 10.1002/Cmdc.200900043 |
0.594 |
|
| 2009 |
Yan Z, Wang H, Cai J, Ke H. Refolding and kinetic characterization of the phosphodiesterase-8A catalytic domain. Protein Expression and Purification. 64: 82-8. PMID 18984055 DOI: 10.1016/J.Pep.2008.10.005 |
0.601 |
|
| 2008 |
Hu X, Wang H, Ke H, Kuhlman B. Computer-based redesign of a beta sandwich protein suggests that extensive negative design is not required for de novo beta sheet design. Structure (London, England : 1993). 16: 1799-805. PMID 19081056 DOI: 10.1016/J.Str.2008.09.013 |
0.559 |
|
| 2008 |
Zheng S, Kaur G, Wang H, Li M, Macnaughtan M, Yang X, Reid S, Prestegard J, Wang B, Ke H. Design, synthesis, and structure - Activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors Journal of Medicinal Chemistry. 51: 7673-7688. PMID 19049349 DOI: 10.1021/Jm701635J |
0.62 |
|
| 2008 |
Wang H, Yan Z, Yang S, Cai J, Robinson H, Ke H. Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity. Biochemistry. 47: 12760-8. PMID 18983167 DOI: 10.1021/Bi801487X |
0.661 |
|
| 2008 |
Chen G, Wang H, Robinson H, Cai J, Wan Y, Ke H. An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies. Biochemical Pharmacology. 75: 1717-28. PMID 18346713 DOI: 10.1016/J.Bcp.2008.01.019 |
0.654 |
|
| 2008 |
Wang H, Ye M, Robinson H, Francis SH, Ke H. Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil. Molecular Pharmacology. 73: 104-10. PMID 17959709 DOI: 10.1124/Mol.107.040212 |
0.651 |
|
| 2007 |
Hu X, Wang H, Ke H, Kuhlman B. High-resolution design of a protein loop. Proceedings of the National Academy of Sciences of the United States of America. 104: 17668-73. PMID 17971437 DOI: 10.1073/Pnas.0707977104 |
0.606 |
|
| 2007 |
Wang H, Yan Z, Geng J, Kunz S, Seebeck T, Ke H. Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors. Molecular Microbiology. 66: 1029-38. PMID 17944832 DOI: 10.1111/J.1365-2958.2007.05976.X |
0.649 |
|
| 2007 |
Wang H, Peng MS, Chen Y, Geng J, Robinson H, Houslay MD, Cai J, Ke H. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. The Biochemical Journal. 408: 193-201. PMID 17727341 DOI: 10.1042/Bj20070970 |
0.662 |
|
| 2007 |
Wang H, Robinson H, Ke H. The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10. Journal of Molecular Biology. 371: 302-7. PMID 17582435 DOI: 10.1016/J.Jmb.2007.05.060 |
0.632 |
|
| 2007 |
Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Structural insight into substrate specificity of phosphodiesterase 10. Proceedings of the National Academy of Sciences of the United States of America. 104: 5782-7. PMID 17389385 DOI: 10.1073/Pnas.0700279104 |
0.652 |
|
| 2007 |
Ke H, Wang H. Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity. Current Topics in Medicinal Chemistry. 7: 391-403. PMID 17305581 DOI: 10.2174/156802607779941242 |
0.665 |
|
| 2006 |
Wang H, Liu Y, Huai Q, Cai J, Zoraghi R, Francis SH, Corbin JD, Robinson H, Xin Z, Lin G, Ke H. Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development. The Journal of Biological Chemistry. 281: 21469-79. PMID 16735511 DOI: 10.1074/Jbc.M512527200 |
0.641 |
|
| 2006 |
Huai Q, Sun Y, Wang H, Macdonald D, Aspiotis R, Robinson H, Huang Z, Ke H. Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase. Journal of Medicinal Chemistry. 49: 1867-73. PMID 16539372 DOI: 10.1021/Jm051273D |
0.636 |
|
| 2005 |
Wang H, Liu Y, Chen Y, Robinson H, Ke H. Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7. The Journal of Biological Chemistry. 280: 30949-55. PMID 15994308 DOI: 10.1074/Jbc.M504398200 |
0.641 |
|
| 2005 |
Huai Q, Wang H, Liu Y, Kim HY, Toft D, Ke H. Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding. Structure (London, England : 1993). 13: 579-90. PMID 15837196 DOI: 10.1016/J.Str.2004.12.018 |
0.622 |
|
| 2004 |
Huai Q, Wang H, Zhang W, Colman RW, Robinson H, Ke H. Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding. Proceedings of the National Academy of Sciences of the United States of America. 101: 9624-9. PMID 15210993 DOI: 10.1073/Pnas.0401120101 |
0.659 |
|
| 2003 |
Huai Q, Sun Y, Wang H, Chin LS, Li L, Robinson H, Ke H. Crystal structure of DJ-1/RS and implication on familial Parkinson's disease. Febs Letters. 549: 171-5. PMID 12914946 DOI: 10.1016/S0014-5793(03)00764-6 |
0.615 |
|
| 2003 |
Huai Q, Wang H, Sun Y, Kim HY, Liu Y, Ke H. Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity. Structure (London, England : 1993). 11: 865-73. PMID 12842049 DOI: 10.1016/S0969-2126(03)00123-0 |
0.654 |
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