| Year |
Citation |
Score |
| 2023 |
Martin-Vega A, Cobb MH. Navigating the ERK1/2 MAPK Cascade. Biomolecules. 13. PMID 37892237 DOI: 10.3390/biom13101555 |
0.3 |
|
| 2019 |
Shen C, Li B, Astudillo L, Deutscher MP, Cobb MH, Capobianco AJ, Lee E, Robbins DJ. The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (/) of CK1α. Biochemistry. PMID 31820934 DOI: 10.1021/Acs.Biochem.9B00891 |
0.304 |
|
| 2016 |
Gallolu Kankanamalage S, Lee AY, Wichaidit C, Lorente-Rodriguez A, Shah AM, Stippec S, Whitehurst AW, Cobb MH. Multistep regulation of autophagy by WNK1. Proceedings of the National Academy of Sciences of the United States of America. PMID 27911840 DOI: 10.1073/pnas.1617649113 |
0.319 |
|
| 2016 |
McReynolds AC, Karra AS, Li Y, Lopez ED, Turjanski AG, Dioum E, Lorenz K, Zaganjor E, Stippec S, McGlynn K, Earnest S, Cobb MH. Phosphorylation or mutation of the ERK2 activation loop alters oligonucleotide binding. Biochemistry. PMID 26950759 DOI: 10.1021/Acs.Biochem.6B00096 |
0.3 |
|
| 2013 |
Sengupta S, Lorente-RodrÃguez A, Earnest S, Stippec S, Guo X, Trudgian DC, Mirzaei H, Cobb MH. Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals. Proceedings of the National Academy of Sciences of the United States of America. 110: 18826-31. PMID 24191005 DOI: 10.1073/Pnas.1318676110 |
0.327 |
|
| 2009 |
Chen W, Chen Y, Xu BE, Juang YC, Stippec S, Zhao Y, Cobb MH. Regulation of a third conserved phosphorylation site in SGK1. The Journal of Biological Chemistry. 284: 3453-60. PMID 19068477 DOI: 10.1074/Jbc.M807502200 |
0.329 |
|
| 2007 |
Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene. 26: 3100-12. PMID 17496909 DOI: 10.1038/sj.onc.1210392 |
0.326 |
|
| 2006 |
Heise CJ, Cobb MH. Expression and characterization of MAP kinases in bacteria. Methods (San Diego, Calif.). 40: 209-12. PMID 16908184 DOI: 10.1016/j.ymeth.2006.06.012 |
0.317 |
|
| 2006 |
Anselmo AN, Earnest S, Chen W, Juang YC, Kim SC, Zhao Y, Cobb MH. WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 10883-8. PMID 16832045 DOI: 10.1073/Pnas.0604607103 |
0.315 |
|
| 2006 |
Ranganathan A, Pearson GW, Chrestensen CA, Sturgill TW, Cobb MH. The MAP kinase ERK5 binds to and phosphorylates p90 RSK. Archives of Biochemistry and Biophysics. 449: 8-16. PMID 16626623 DOI: 10.1016/J.Abb.2006.02.023 |
0.31 |
|
| 2006 |
Pearson GW, Earnest S, Cobb MH. Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals. Molecular and Cellular Biology. 26: 3039-47. PMID 16581779 DOI: 10.1128/MCB.26.8.3039-3047.2006 |
0.317 |
|
| 2006 |
Chen Z, Cobb MH. Activation of MEKK1 by Rho GTPases. Methods in Enzymology. 406: 468-78. PMID 16472679 DOI: 10.1016/S0076-6879(06)06035-6 |
0.329 |
|
| 2005 |
Xu BE, Stippec S, Lazrak A, Huang CL, Cobb MH. WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. The Journal of Biological Chemistry. 280: 34218-23. PMID 16081417 DOI: 10.1074/jbc.M505735200 |
0.312 |
|
| 2004 |
Zhou T, Raman M, Gao Y, Earnest S, Chen Z, Machius M, Cobb MH, Goldsmith EJ. Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K. Structure (London, England : 1993). 12: 1891-900. PMID 15458637 DOI: 10.1016/J.Str.2004.07.021 |
0.312 |
|
| 2004 |
Anselmo AN, Cobb MH. Protein kinase function and glutathionylation. The Biochemical Journal. 381: e1-2. PMID 15270699 DOI: 10.1042/BJ20040873 |
0.3 |
|
| 2004 |
Whitehurst AW, Robinson FL, Moore MS, Cobb MH. The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions. The Journal of Biological Chemistry. 279: 12840-7. PMID 14707138 DOI: 10.1074/Jbc.M310031200 |
0.31 |
|
| 2004 |
Chen W, Yazicioglu M, Cobb MH. Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. The Journal of Biological Chemistry. 279: 11129-36. PMID 14707132 DOI: 10.1074/jbc.M313562200 |
0.344 |
|
| 2004 |
Xu BE, Stippec S, Lenertz L, Lee BH, Zhang W, Lee YK, Cobb MH. WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. The Journal of Biological Chemistry. 279: 7826-31. PMID 14681216 DOI: 10.1074/Jbc.M313465200 |
0.315 |
|
| 2004 |
Gallagher ED, Gutowski S, Sternweis PC, Cobb MH. RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity. The Journal of Biological Chemistry. 279: 1872-7. PMID 14581471 DOI: 10.1074/Jbc.M309525200 |
0.311 |
|
| 2003 |
Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH. TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. The Journal of Biological Chemistry. 278: 22278-83. PMID 12665513 DOI: 10.1074/Jbc.M301173200 |
0.325 |
|
| 2002 |
Chen W, White MA, Cobb MH. Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway. The Journal of Biological Chemistry. 277: 49105-10. PMID 12351623 DOI: 10.1074/jbc.M204934200 |
0.32 |
|
| 2002 |
Pearson GW, Cobb MH. Cell condition-dependent regulation of ERK5 by cAMP. The Journal of Biological Chemistry. 277: 48094-8. PMID 12297510 DOI: 10.1074/jbc.M208535200 |
0.314 |
|
| 2002 |
Gallagher ED, Xu S, Moomaw C, Slaughter CA, Cobb MH. Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation. The Journal of Biological Chemistry. 277: 45785-92. PMID 12228228 DOI: 10.1074/jbc.M207702200 |
0.309 |
|
| 2002 |
Christerson LB, Gallagher E, Vanderbilt CA, Whitehurst AW, Wells C, Kazempour R, Sternweis PC, Cobb MH. p115 Rho GTPase activating protein interacts with MEKK1. Journal of Cellular Physiology. 192: 200-8. PMID 12115726 DOI: 10.1002/Jcp.10125 |
0.303 |
|
| 2002 |
Robinson FL, Whitehurst AW, Raman M, Cobb MH. Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1. The Journal of Biological Chemistry. 277: 14844-52. PMID 11823456 DOI: 10.1074/Jbc.M107776200 |
0.328 |
|
| 2001 |
Berman KS, Hutchison M, Avery L, Cobb MH. kin-18, a C. elegans protein kinase involved in feeding. Gene. 279: 137-47. PMID 11733138 DOI: 10.1016/S0378-1119(01)00752-1 |
0.313 |
|
| 2001 |
Chen Z, Cobb MH. Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. The Journal of Biological Chemistry. 276: 16070-5. PMID 11279118 DOI: 10.1074/jbc.M100681200 |
0.318 |
|
| 2000 |
Pearson G, Bumeister R, Henry DO, Cobb MH, White MA. Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation. The Journal of Biological Chemistry. 275: 37303-6. PMID 11018021 DOI: 10.1074/Jbc.C000570200 |
0.323 |
|
| 2000 |
Karandikar M, Xu S, Cobb MH. MEKK1 binds raf-1 and the ERK2 cascade components. The Journal of Biological Chemistry. 275: 40120-7. PMID 10969079 DOI: 10.1074/jbc.M005926200 |
0.326 |
|
| 2000 |
Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH. WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. The Journal of Biological Chemistry. 275: 16795-801. PMID 10828064 DOI: 10.1074/Jbc.275.22.16795 |
0.309 |
|
| 2000 |
Nichols A, Camps M, Gillieron C, Chabert C, Brunet A, Wilsbacher J, Cobb M, Pouyssegur J, Shaw JP, Arkinstall S. Substrate recognition domains within extracellular signal-regulated kinase mediate binding and catalytic activation of mitogen-activated protein kinase phosphatase-3. The Journal of Biological Chemistry. 275: 24613-21. PMID 10811804 DOI: 10.1074/Jbc.M001515200 |
0.403 |
|
| 2000 |
Chaudhary A, King WG, Mattaliano MD, Frost JA, Diaz B, Morrison DK, Cobb MH, Marshall MS, Brugge JS. Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Current Biology : Cb. 10: 551-4. PMID 10801448 DOI: 10.1016/S0960-9822(00)00475-9 |
0.309 |
|
| 2000 |
Liou J, Kiefer F, Dang A, Hashimoto A, Cobb MH, Kurosaki T, Weiss A. HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1. Immunity. 12: 399-408. PMID 10795738 DOI: 10.1016/S1074-7613(00)80192-2 |
0.308 |
|
| 1999 |
Karandikar M, Cobb MH. Scaffolding and protein interactions in MAP kinase modules. Cell Calcium. 26: 219-26. PMID 10643560 DOI: 10.1054/ceca.1999.0074 |
0.306 |
|
| 1999 |
Wang J, Frost JA, Cobb MH, Ross EM. Reciprocal signaling between heterotrimeric G proteins and the p21-stimulated protein kinase. The Journal of Biological Chemistry. 274: 31641-7. PMID 10531372 DOI: 10.1074/Jbc.274.44.31641 |
0.302 |
|
| 1999 |
Chen Z, Hutchison M, Cobb MH. Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain. The Journal of Biological Chemistry. 274: 28803-7. PMID 10497253 DOI: 10.1074/jbc.274.40.28803 |
0.314 |
|
| 1998 |
Robinson MJ, Stippec SA, Goldsmith E, White MA, Cobb MH. A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation. Current Biology : Cb. 8: 1141-50. PMID 9799732 DOI: 10.1016/S0960-9822(07)00485-X |
0.331 |
|
| 1998 |
Hutchison M, Berman KS, Cobb MH. Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. The Journal of Biological Chemistry. 273: 28625-32. PMID 9786855 DOI: 10.1074/jbc.273.44.28625 |
0.32 |
|
| 1998 |
Dang A, Frost JA, Cobb MH. The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells. The Journal of Biological Chemistry. 273: 19909-13. PMID 9677429 DOI: 10.1074/jbc.273.31.19909 |
0.317 |
|
| 1997 |
Xu S, Cobb MH. MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. The Journal of Biological Chemistry. 272: 32056-60. PMID 9405400 DOI: 10.1074/jbc.272.51.32056 |
0.332 |
|
| 1997 |
Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, Shaw PE, Cobb MH. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. The Embo Journal. 16: 6426-38. PMID 9351825 DOI: 10.1093/Emboj/16.21.6426 |
0.31 |
|
| 1997 |
Xu S, Khoo S, Dang A, Witt S, Do V, Zhen E, Schaefer EM, Cobb MH. Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism. Molecular Endocrinology (Baltimore, Md.). 11: 1618-25. PMID 9328344 DOI: 10.1210/mend.11.11.0010 |
0.332 |
|
| 1997 |
Khokhlatchev A, Xu S, English J, Wu P, Schaefer E, Cobb MH. Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases. The Journal of Biological Chemistry. 272: 11057-62. PMID 9110999 DOI: 10.1074/jbc.272.17.11057 |
0.318 |
|
| 1996 |
Cobb MH, Xu S, Cheng M, Ebert D, Robbins D, Goldsmith E, Robinson M. Structural analysis of the MAP kinase ERK2 and studies of MAP kinase regulatory pathways. Advances in Pharmacology (San Diego, Calif.). 36: 49-65. PMID 8783554 DOI: 10.1016/S1054-3589(08)60576-1 |
0.326 |
|
| 1996 |
Frost JA, Xu S, Hutchison MR, Marcus S, Cobb MH. Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Molecular and Cellular Biology. 16: 3707-13. PMID 8668187 DOI: 10.1128/Mcb.16.7.3707 |
0.333 |
|
| 1996 |
Cheng M, Zhen E, Robinson MJ, Ebert D, Goldsmith E, Cobb MH. Characterization of a protein kinase that phosphorylates serine 189 of the mitogen-activated protein kinase homolog ERK3. The Journal of Biological Chemistry. 271: 12057-62. PMID 8662649 DOI: 10.1074/Jbc.271.20.12057 |
0.315 |
|
| 1996 |
Cheng M, Boulton TG, Cobb MH. ERK3 is a constitutively nuclear protein kinase. The Journal of Biological Chemistry. 271: 8951-8. PMID 8621539 DOI: 10.1074/jbc.271.15.8951 |
0.32 |
|
| 1995 |
Xu S, Robbins D, Frost J, Dang A, Lange-Carter C, Cobb MH. MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 92: 6808-12. PMID 7624324 DOI: 10.1073/pnas.92.15.6808 |
0.334 |
|
| 1995 |
Marcus S, Polverino A, Chang E, Robbins D, Cobb MH, Wigler MH. Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proceedings of the National Academy of Sciences of the United States of America. 92: 6180-4. PMID 7597098 DOI: 10.1073/Pnas.92.13.6180 |
0.304 |
|
| 1995 |
Polverino A, Frost J, Yang P, Hutchison M, Neiman AM, Cobb MH, Marcus S. Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes. The Journal of Biological Chemistry. 270: 26067-70. PMID 7592806 DOI: 10.1074/Jbc.270.44.26067 |
0.313 |
|
| 1995 |
English JM, Vanderbilt CA, Xu S, Marcus S, Cobb MH. Isolation of MEK5 and differential expression of alternatively spliced forms. The Journal of Biological Chemistry. 270: 28897-902. PMID 7499418 DOI: 10.1074/Jbc.270.48.28897 |
0.303 |
|
| 1994 |
Zhang F, Strand A, Robbins D, Cobb MH, Goldsmith EJ. Atomic structure of the MAP kinase ERK2 at 2.3 A resolution. Nature. 367: 704-11. PMID 8107865 DOI: 10.1038/367704A0 |
0.301 |
|
| 1993 |
Robbins DJ, Zhen E, Owaki H, Vanderbilt CA, Ebert D, Geppert TD, Cobb MH. Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. The Journal of Biological Chemistry. 268: 5097-106. PMID 8444886 |
0.322 |
|
| 1993 |
Cheng JT, Cobb MH, Baer R. Phosphorylation of the TAL1 Oncoprotein by the Extracellular-Signal-Regulated Protein Kinase ERK1 Molecular and Cellular Biology. 13: 801-808. PMID 8423803 DOI: 10.1128/mcb.13.2.801-808.1993 |
0.326 |
|
| 1993 |
Sontag E, Fedorov S, Kamibayashi C, Robbins D, Cobb M, Mumby M. The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation. Cell. 75: 887-97. PMID 8252625 DOI: 10.1016/0092-8674(93)90533-V |
0.378 |
|
| 1993 |
Cheng JT, Cobb MH, Baer R. Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1. Molecular and Cellular Biology. 13: 801-808. DOI: 10.1128/MCB.13.2.801 |
0.326 |
|
| 1992 |
Funasaka Y, Boulton T, Cobb M, Yarden Y, Fan B, Lyman SD, Williams DE, Anderson DM, Zakut R, Mishima Y. c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas. Molecular Biology of the Cell. 3: 197-209. PMID 1372524 DOI: 10.1091/Mbc.3.2.197 |
0.409 |
|
| 1992 |
Haycock JW, Ahn NG, Cobb MH, Krebs EG. ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ. Proceedings of the National Academy of Sciences of the United States of America. 89: 2365-9. PMID 1347949 DOI: 10.1073/Pnas.89.6.2365 |
0.307 |
|
| 1992 |
Shibuya EK, Boulton TG, Cobb MH, Ruderman JV. Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest. The Embo Journal. 11: 3963-75. PMID 1327752 DOI: 10.1002/J.1460-2075.1992.Tb05490.X |
0.301 |
|
| 1992 |
Ahn NG, Robbins DJ, Haycock JW, Seger R, Cobb MH, Krebs EG. Identification of an activator of the microtubule-associated protein 2 kinases ERK1 and ERK2 in PC12 cells stimulated with nerve growth factor or bradykinin. Journal of Neurochemistry. 59: 147-56. PMID 1319464 DOI: 10.1111/J.1471-4159.1992.Tb08885.X |
0.322 |
|
| 1991 |
Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, DePinho RA, Panayotatos N, Cobb MH, Yancopoulos GD. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell. 65: 663-75. PMID 2032290 DOI: 10.1016/0092-8674(91)90098-J |
0.318 |
|
| 1991 |
Seger R, Ahn NG, Boulton TG, Yancopoulos GD, Panayotatos N, Radziejewska E, Ericsson L, Bratlien RL, Cobb MH, Krebs EG. Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation. Proceedings of the National Academy of Sciences of the United States of America. 88: 6142-6. PMID 1712480 DOI: 10.1073/Pnas.88.14.6142 |
0.317 |
|
| 1991 |
Cobb MH, Robbins DJ, Boulton TG. ERKs, extracellular signal-regulated MAP-2 kinases. Current Opinion in Cell Biology. 3: 1025-32. PMID 1667578 DOI: 10.1016/0955-0674(91)90124-H |
0.316 |
|
| 1991 |
Boulton TG, Cobb MH. Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies Cell Regulation. 2: 357-371. PMID 1654126 DOI: 10.1091/MBC.2.5.357 |
0.32 |
|
| 1990 |
Boulton TG, Yancopoulos GD, Gregory JS, Slaughter C, Moomaw C, Hsu J, Cobb MH. An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control Science. 249: 64-67. PMID 2164259 DOI: 10.1126/SCIENCE.2164259 |
0.33 |
|
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