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Emmanuel Skordalakes - Publications

Affiliations: 
Chemistry University of Pennsylvania, Philadelphia, PA, United States 
Area:
Gene Expression and Regulation
Website:
http://webdev.chem.upenn.edu/chem/research/faculty.php?id=52
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Al-Shareef W, Brown Y, Bryan C, Shuvaeva E, Bsoul S, Greenman R, Kabaha MM, Ulyanov NB, Skordalakes E, Tzfati Y. Functional Interactions of Telomerase Reverse Transcriptase with the Three-Way Junction and the Template Domains of Telomerase RNA. International Journal of Molecular Sciences. 23. PMID 36142669 DOI: 10.3390/ijms231810757  0.34
2020 Aramburu T, Plucinsky S, Skordalakes E. POT1-TPP1 telomere length regulation and disease. Computational and Structural Biotechnology Journal. 18: 1939-1946. PMID 32774788 DOI: 10.1016/J.Csbj.2020.06.040  0.374
2020 Ren W, Medeiros N, Warneford-Thomson R, Wulfridge P, Yan Q, Bian J, Sidoli S, Garcia BA, Skordalakes E, Joyce E, Bonasio R, Sarma K. Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function. Nature Communications. 11: 2219. PMID 32376827 DOI: 10.1038/S41467-020-15902-9  0.397
2019 Di Sante G, Pagé J, Jiao X, Nawab O, Cristofanilli M, Skordalakes E, Pestell RG. Recent advances with cyclin-dependent kinase inhibitors: therapeutic agents for breast cancer and their role in immuno-oncology. Expert Review of Anticancer Therapy. 1-19. PMID 31219365 DOI: 10.1080/14737140.2019.1615889  0.315
2019 Hernandez-Sanchez W, Huang W, Plucinsky B, Garcia-Vazquez N, Robinson NJ, Schiemann WP, Berdis AJ, Skordalakes E, Taylor DJ. A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity. Plos Biology. 17: e3000204. PMID 30951520 DOI: 10.1371/Journal.Pbio.3000204  0.424
2017 Shastrula PK, Rice CT, Wang Z, Lieberman PM, Skordalakes E. Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes. Nucleic Acids Research. PMID 29228254 DOI: 10.1093/Nar/Gkx1213  0.463
2017 Sakurai M, Shiromoto Y, Ota H, Song C, Kossenkov AV, Wickramasinghe J, Showe LC, Skordalakes E, Tang HY, Speicher DW, Nishikura K. ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay. Nature Structural & Molecular Biology. PMID 28436945 DOI: 10.1038/Nsmb.3403  0.328
2017 Rice C, Shastrula PK, Kossenkov AV, Hills R, Baird DM, Showe LC, Doukov T, Janicki S, Skordalakes E. Structural and functional analysis of the human POT1-TPP1 telomeric complex. Nature Communications. 8: 14928. PMID 28393830 DOI: 10.1038/Ncomms14928  0.404
2017 Hoffman H, Rice C, Skordalakes E. Structural Analysis Reveals the Deleterious Effects of Telomerase Mutations in Telomerase-Associated Bone Marrow Failure Syndromes. The Journal of Biological Chemistry. PMID 28154186 DOI: 10.1074/Jbc.M116.771204  0.359
2016 Hoffman H, Skordalakes E. Crystallographic Studies of Telomerase. Methods in Enzymology. 573: 403-19. PMID 27372764 DOI: 10.1016/Bs.Mie.2016.04.006  0.413
2016 Rice C, Skordalakes E. Structure and function of the telomeric CST complex. Computational and Structural Biotechnology Journal. 14: 161-7. PMID 27239262 DOI: 10.1016/J.Csbj.2016.04.002  0.351
2015 Bryan C, Rice C, Hoffman H, Harkisheimer M, Sweeney M, Skordalakes E. Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532. Structure (London, England : 1993). 23: 1934-42. PMID 26365799 DOI: 10.1016/J.Str.2015.08.006  0.435
2015 Greetham M, Skordalakes E, Lydall D, Connolly BA. The Telomere Binding Protein Cdc13 and the Single-Stranded DNA Binding Protein RPA Protect Telomeric DNA from Resection by Exonucleases. Journal of Molecular Biology. 427: 3023-30. PMID 26264873 DOI: 10.1016/J.Jmb.2015.08.002  0.407
2015 Iwasaki O, Tanizawa H, Kim KD, Yokoyama Y, Corcoran CJ, Tanaka A, Skordalakes E, Showe LC, Noma K. Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes. Molecular Cell. 59: 755-67. PMID 26257282 DOI: 10.1016/J.Molcel.2015.07.007  0.312
2015 Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Science Signaling. 8: ra58. PMID 26082434 DOI: 10.1126/Scisignal.Aaa4998  0.358
2014 Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, ... ... Skordalakes E, et al. LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase. Cancer Research. 74: 1390-403. PMID 24590809 DOI: 10.1158/0008-5472.Can-13-1275  0.343
2014 Peng H, Farrooji MTZ, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, ... ... Skordalakes E, et al. Abstract 992: LIMD2 is a small LIM-only protein overexpressed in metastatic lesions which regulates cell motility and tumor progression by directly binding to and activating the integrin-linked-kinase Cancer Research. 74: 992-992. DOI: 10.1158/1538-7445.Am2014-992  0.366
2014 Bryan C, Rice C, Harkisheimer M, Schultz D, Skordalakes E. Structure of the Human Telomeric Stn1-Ten1 Complex Acta Crystallographica Section A. 70. DOI: 10.1107/S2053273314084125  0.395
2013 Harkisheimer M, Mason M, Shuvaeva E, Skordalakes E. A motif in the vertebrate telomerase N-terminal linker of TERT contributes to RNA binding and telomerase activity and processivity. Structure (London, England : 1993). 21: 1870-8. PMID 24055314 DOI: 10.1016/J.Str.2013.08.013  0.467
2013 Bryan C, Rice C, Harkisheimer M, Schultz DC, Skordalakes E. Structure of the human telomeric Stn1-Ten1 capping complex. Plos One. 8: e66756. PMID 23826127 DOI: 10.1371/Journal.Pone.0066756  0.446
2013 Newhart A, Rafalska-Metcalf IU, Yang T, Joo LM, Powers SL, Kossenkov AV, Lopez-Jones M, Singer RH, Showe LC, Skordalakes E, Janicki SM. Single cell analysis of RNA-mediated histone H3.3 recruitment to a cytomegalovirus promoter-regulated transcription site. The Journal of Biological Chemistry. 288: 19882-99. PMID 23689370 DOI: 10.1074/Jbc.M113.473181  0.371
2013 Mason M, Wanat JJ, Harper S, Schultz DC, Speicher DW, Johnson FB, Skordalakes E. Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance. Structure (London, England : 1993). 21: 109-20. PMID 23177925 DOI: 10.1016/J.Str.2012.10.012  0.454
2011 Schuller AP, Harkisheimer MJ, Skordalakes E. In vitro reconstitution of the active T. castaneum telomerase. Journal of Visualized Experiments : Jove. e2799. PMID 21775967 DOI: 10.3791/2799  0.432
2011 Mason M, Schuller A, Skordalakes E. Telomerase structure function. Current Opinion in Structural Biology. 21: 92-100. PMID 21168327 DOI: 10.1016/J.Sbi.2010.11.005  0.441
2010 Mitchell MT, Smith JS, Mason M, Harper S, Speicher DW, Johnson FB, Skordalakes E. Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation. Molecular and Cellular Biology. 30: 5325-34. PMID 20837709 DOI: 10.1128/Mcb.00515-10  0.449
2010 Mitchell M, Gillis A, Futahashi M, Fujiwara H, Skordalakes E. Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA. Nature Structural & Molecular Biology. 17: 513-8. PMID 20357774 DOI: 10.1038/Nsmb.1777  0.42
2010 McCray BA, Skordalakes E, Taylor JP. Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation. Human Molecular Genetics. 19: 1033-47. PMID 20028791 DOI: 10.1093/Hmg/Ddp567  0.348
2009 Wang AY, Schulze JM, Skordalakes E, Gin JW, Berger JM, Rine J, Kobor MS. Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation. Proceedings of the National Academy of Sciences of the United States of America. 106: 21573-8. PMID 19966225 DOI: 10.1073/Pnas.0906539106  0.582
2009 Skordalakes E. Telomerase structure paves the way for new cancer therapies. Future Oncology (London, England). 5: 163-7. PMID 19284375 DOI: 10.2217/14796694.5.2.163  0.321
2008 Gillis AJ, Schuller AP, Skordalakes E. Structure of the Tribolium castaneum telomerase catalytic subunit TERT. Nature. 455: 633-7. PMID 18758444 DOI: 10.1038/Nature07283  0.478
2008 Carlson BL, Ballister ER, Skordalakes E, King DS, Breidenbach MA, Gilmore SA, Berger JM, Bertozzi CR. Function and structure of a prokaryotic formylglycine-generating enzyme. The Journal of Biological Chemistry. 283: 20117-25. PMID 18390551 DOI: 10.1074/Jbc.M800217200  0.555
2007 Rouda S, Skordalakes E. Structure of the RNA-binding domain of telomerase: implications for RNA recognition and binding. Structure (London, England : 1993). 15: 1403-12. PMID 17997966 DOI: 10.1016/J.Str.2007.09.007  0.448
2007 Young TA, Skordalakes E, Marqusee S. Comparison of proteolytic susceptibility in phosphoglycerate kinases from yeast and E. coli: modulation of conformational ensembles without altering structure or stability. Journal of Molecular Biology. 368: 1438-47. PMID 17397866 DOI: 10.1016/J.Jmb.2007.02.077  0.373
2006 Skordalakes E, Berger JM. Structural insights into RNA-dependent ring closure and ATPase activation by the Rho termination factor. Cell. 127: 553-64. PMID 17081977 DOI: 10.1016/J.Cell.2006.08.051  0.592
2005 Skordalakes E, Brogan AP, Park BS, Kohn H, Berger JM. Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin. Structure (London, England : 1993). 13: 99-109. PMID 15642265 DOI: 10.1016/J.Str.2004.10.013  0.589
2003 Daganzo SM, Erzberger JP, Lam WM, Skordalakes E, Zhang R, Franco AA, Brill SJ, Adams PD, Berger JM, Kaufman PD. Structure and function of the conserved core of histone deposition protein Asf1. Current Biology : Cb. 13: 2148-58. PMID 14680630 DOI: 10.1016/J.Cub.2003.11.027  0.682
2003 Skordalakes E, Berger JM. Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading. Cell. 114: 135-46. PMID 12859904 DOI: 10.1016/S0092-8674(03)00512-9  0.567
2002 Hansen CL, Skordalakes E, Berger JM, Quake SR. A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion. Proceedings of the National Academy of Sciences of the United States of America. 99: 16531-6. PMID 12486223 DOI: 10.1073/Pnas.262485199  0.479
2001 Skordalakes E, Dodson GG, Green DS, Goodwin CA, Scully MF, Hudson HR, Kakkar VV, Deadman JJ. Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate. Journal of Molecular Biology. 311: 549-55. PMID 11493008 DOI: 10.1006/Jmbi.2001.4872  0.309
1999 Green D, Skordalakes E, Scully MF, Goodwin C, Merette S, Burd A, Kakkar VV, Deadman J. X-ray crystallographic analyses of human α-thrombin complexed to peptidyl aminophosphonates: Evidence of a binding mechanism Phosphorus, Sulfur and Silicon and Related Elements. 144: 545-548. DOI: 10.1080/10426509908546302  0.337
1998 Skordalakes E, Elgendy S, Goodwin CA, Green D, Scully MF, Kakkar VV, Freyssinet JM, Dodson G, Deadman JJ. Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide. Biochemistry. 37: 14420-7. PMID 9772168 DOI: 10.1021/Bi980225A  0.313
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