Year |
Citation |
Score |
2023 |
Pantelejevs T, Zuazua-Villar P, Koczy O, Counsell AJ, Walsh SJ, Robertson NS, Spring DR, Downs JA, Hyvönen M. A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase. Chemical Science. 14: 13915-13923. PMID 38075664 DOI: 10.1039/d3sc03331g |
0.618 |
|
2022 |
Brear P, De Fusco C, Atkinson EL, Iegre J, Francis-Newton NJ, Venkitaraman AR, Hyvönen M, Spring DR. A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action. Rsc Medicinal Chemistry. 13: 1420-1426. PMID 36426237 DOI: 10.1039/d2md00161f |
0.639 |
|
2022 |
Atkinson EL, Iegre J, D'Amore C, Brear P, Salvi M, Hyvönen M, Spring DR. Development of small cyclic peptides targeting the CK2α/β interface. Chemical Communications (Cambridge, England). 58: 4791-4794. PMID 35343996 DOI: 10.1039/d2cc00707j |
0.619 |
|
2021 |
Iegre J, Atkinson EL, Brear PD, Cooper BM, Hyvönen M, Spring DR. Chemical probes targeting the kinase CK2: a journey outside the catalytic box. Organic & Biomolecular Chemistry. 19: 4380-4396. PMID 34037044 DOI: 10.1039/d1ob00257k |
0.647 |
|
2021 |
Atkinson EL, Iegre J, Brear PD, Zhabina EA, Hyvönen M, Spring DR. Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study. Molecules (Basel, Switzerland). 26. PMID 33807474 DOI: 10.3390/molecules26071977 |
0.627 |
|
2020 |
Kidd SL, Fowler E, Reinhardt T, Compton T, Mateu N, Newman H, Bellini D, Talon R, McLoughlin J, Krojer T, Aimon A, Bradley A, Fairhead M, Brear P, Díaz-Sáez L, ... ... Spring DR, et al. Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion. Chemical Science. 11: 10792-10801. PMID 34094333 DOI: 10.1039/d0sc01232g |
0.626 |
|
2020 |
Strizhak AV, Babii O, Afonin S, Bakanovich I, Pantelejevs T, Xu W, Fowler E, Eapen R, Sharma K, Platonov MO, Hurmach VV, Itzhaki L, Hyvönen M, Ulrich AS, Spring DR, et al. Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction. Organic & Biomolecular Chemistry. PMID 32390036 DOI: 10.1039/d0ob00831a |
0.619 |
|
2019 |
Sharma P, Mahen R, Rossmann M, Stokes JE, Hardwick B, Huggins DJ, Emery A, Kunciw DL, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR. A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation. Scientific Reports. 9: 15930. PMID 31685831 DOI: 10.1038/S41598-019-50702-2 |
0.6 |
|
2019 |
Sharma K, Strizhak AV, Fowler E, Wang X, Xu W, Hatt Jensen C, Wu Y, Sore HF, Lau YH, Hyvönen M, Itzhaki LS, Spring DR. Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry. Organic & Biomolecular Chemistry. PMID 31418442 DOI: 10.1039/c9ob01745c |
0.596 |
|
2019 |
Iegre J, Brear P, Baker DJ, Tan YS, Atkinson EL, Sore HF, O' Donovan DH, Verma CS, Hyvönen M, Spring DR. Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction. Chemical Science. 10: 5056-5063. PMID 31183056 DOI: 10.1039/c9sc00798a |
0.644 |
|
2019 |
Walsh SJ, Omarjee S, Galloway WRJD, Kwan TT, Sore HF, Parker JS, Hyvönen M, Carroll JS, Spring DR. Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates. Chemical Science. 10: 633-634. PMID 30778404 DOI: 10.1039/c8sc90248h |
0.591 |
|
2019 |
Walsh SJ, Omarjee S, Galloway WRJD, Kwan TT, Sore HF, Parker JS, Hyvönen M, Carroll JS, Spring DR. A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates. Chemical Science. 10: 694-700. PMID 30774870 DOI: 10.1039/c8sc04645j |
0.594 |
|
2018 |
Brear P, North A, Iegre J, Hadje Georgiou K, Lubin A, Carro L, Green W, Sore HF, Hyvönen M, Spring DR. Novel non-ATP competitive small molecules targeting the CK2 α/β interface. Bioorganic & Medicinal Chemistry. PMID 29759799 DOI: 10.1016/j.bmc.2018.05.011 |
0.622 |
|
2018 |
Iegre J, Brear P, De Fusco C, Yoshida M, Mitchell SL, Rossmann M, Carro L, Sore HF, Hyvönen M, Spring DR. Second-generation CK2α inhibitors targeting the αD pocket. Chemical Science. 9: 3041-3049. PMID 29732088 DOI: 10.1039/c7sc05122k |
0.622 |
|
2017 |
Cole DJ, Janecek M, Stokes JE, Rossmann M, Faver JC, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR, Huggins DJ, Jorgensen WL. Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction. Chemical Communications (Cambridge, England). PMID 28787041 DOI: 10.1039/C7Cc05379G |
0.61 |
|
2017 |
De Fusco C, Brear P, Iegre J, Georgiou KH, Sore HF, Hyvönen M, Spring DR. A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066. Bioorganic & Medicinal Chemistry. PMID 28495381 DOI: 10.1016/j.bmc.2017.04.037 |
0.64 |
|
2017 |
Ciardiello JJ, Stewart HL, Sore HF, Galloway WR, Spring DR. A novel complexity-to-diversity strategy for the diversity-oriented synthesis of structurally diverse and complex macrocycles from quinine. Bioorganic & Medicinal Chemistry. PMID 28283333 DOI: 10.1016/J.Bmc.2017.02.060 |
0.325 |
|
2017 |
Xu W, Lau YH, Fischer G, Tan YS, Chattopadhyay A, de la Roche M, Hyvonen M, Verma CS, Spring DR, Itzhaki LS. Macrocyclized extended peptides: Inhibiting the substrate-recognition domain of tankyrase. Journal of the American Chemical Society. PMID 28084734 DOI: 10.1021/jacs.6b10234 |
0.621 |
|
2016 |
Hodgkinson JT, Gross J, Baker YR, Spring DR, Welch M. A new Pseudomonas quinolone signal (PQS) binding partner: MexG. Chemical Science. 7: 2553-2562. PMID 28660026 DOI: 10.1039/C5Sc04197J |
0.341 |
|
2016 |
Brear P, De Fusco C, Hadje Georgiou K, Francis-Newton NJ, Stubbs CJ, Sore HF, Venkitaraman AR, Abell C, Spring DR, Hyvönen M. Specific inhibition of CK2α from an anchor outside the active site. Chemical Science. 7: 6839-6845. PMID 28451126 DOI: 10.1039/C6Sc02335E |
0.63 |
|
2016 |
Janeček M, Rossmann M, Sharma P, Emery A, Huggins DJ, Stockwell SR, Stokes JE, Tan YS, Almeida EG, Hardwick B, Narvaez AJ, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR. Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Scientific Reports. 6: 28528. PMID 27339427 DOI: 10.1038/Srep28528 |
0.633 |
|
2015 |
Lau YH, Wu Y, Rossmann M, Tan BX, de Andrade P, Tan YS, Verma C, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR. Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides. Angewandte Chemie (International Ed. in English). 54: 15410-3. PMID 26768531 DOI: 10.1002/Anie.201508416 |
0.628 |
|
2015 |
Alanine TA, Galloway WR, Bartlett S, Ciardiello JJ, McGuire TM, Spring DR. Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen. Organic & Biomolecular Chemistry. PMID 26632452 DOI: 10.1039/C5Ob01784J |
0.349 |
|
2014 |
Liu T, Liu X, Spring DR, Qian X, Cui J, Xu Z. Quantitatively mapping cellular viscosity with detailed organelle information via a designed PET fluorescent probe. Scientific Reports. 4: 5418. PMID 24957323 DOI: 10.1038/srep05418 |
0.669 |
|
2013 |
Liu T, Xu Z, Spring DR, Cui J. A lysosome-targetable fluorescent probe for imaging hydrogen sulfide in living cells. Organic Letters. 15: 2310-3. PMID 23614763 DOI: 10.1021/ol400973v |
0.598 |
|
2012 |
Xu Z, Liu X, Pan J, Spring DR. Coumarin-derived transformable fluorescent sensor for Zn2+. Chemical Communications (Cambridge, England). 48: 4764-6. PMID 22472965 DOI: 10.1039/c2cc30963g |
0.581 |
|
2012 |
Zheng S, Laraia L, O' Connor CJ, Sorrell D, Tan YS, Xu Z, Venkitaraman AR, Wu W, Spring DR. Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity. Organic & Biomolecular Chemistry. 10: 2590-3. PMID 22361895 DOI: 10.1039/c2ob25065a |
0.597 |
|
2012 |
Cilibrizzi A, Isidro-Llobet A, Mateu N, Galloway WRJD, Spring DR. Novel phosphate derivatives as scaffolds for the preparation of synthetic phosphoserine-based peptides using the Fmoc/ t -Bu solid-phase strategy Synlett. 290-294. DOI: 10.1055/S-0031-1290119 |
0.615 |
|
2011 |
Xu Z, Spring DR, Yoon J. Fluorescent sensing and discrimination of ATP and ADP based on a unique sandwich assembly of pyrene-adenine-pyrene. Chemistry, An Asian Journal. 6: 2114-22. PMID 21506284 DOI: 10.1002/Asia.201100120 |
0.673 |
|
2011 |
Isidro-Llobet A, Murillo T, Bello P, Cilibrizzi A, Hodgkinson JT, Galloway WR, Bender A, Welch M, Spring DR. Diversity-oriented synthesis of macrocyclic peptidomimetics. Proceedings of the National Academy of Sciences of the United States of America. 108: 6793-8. PMID 21383137 DOI: 10.1073/Pnas.1015267108 |
0.654 |
|
2011 |
Xu Z, Singh NJ, Kim SK, Spring DR, Kim KS, Yoon J. Induction-driven stabilization of the anion-π interaction in electron-rich aromatics as the key to fluoride inclusion in imidazolium-cage receptors. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 1163-70. PMID 21243682 DOI: 10.1002/Chem.201002105 |
0.656 |
|
2010 |
Xu Z, Zheng S, Yoon J, Spring DR. Discovery of a highly selective turn-on fluorescent probe for Ag+. The Analyst. 135: 2554-9. PMID 20830329 DOI: 10.1039/C0An00405G |
0.671 |
|
2010 |
Xu Z, Yoon J, Spring DR. A selective and ratiometric Cu2+ fluorescent probe based on naphthalimide excimer-monomer switching. Chemical Communications (Cambridge, England). 46: 2563-5. PMID 20461870 DOI: 10.1039/C000441C |
0.655 |
|
2010 |
Xu Z, Yoon J, Spring DR. Fluorescent chemosensors for Zn(2+). Chemical Society Reviews. 39: 1996-2006. PMID 20428518 DOI: 10.1039/B916287A |
0.655 |
|
2010 |
Xu Z, Han SJ, Lee C, Yoon J, Spring DR. Development of off-on fluorescent probes for heavy and transition metal ions. Chemical Communications (Cambridge, England). 46: 1679-81. PMID 20177614 DOI: 10.1039/B924503K |
0.649 |
|
2010 |
Xu Z, Baek KH, Kim HN, Cui J, Qian X, Spring DR, Shin I, Yoon J. Zn2+-triggered amide tautomerization produces a highly Zn2+-selective, cell-permeable, and ratiometric fluorescent sensor. Journal of the American Chemical Society. 132: 601-10. PMID 20000765 DOI: 10.1021/ja907334j |
0.712 |
|
2010 |
Xu Z, Pan J, Spring DR, Cui J, Yoon J. Ratiometric fluorescent and colorimetric sensors for Cu2+ based on 4,5-disubstituted-1,8-naphthalimide and sensing cyanide via Cu2+ displacement approach Tetrahedron. 66: 1678-1683. DOI: 10.1016/J.Tet.2010.01.008 |
0.409 |
|
2010 |
Xu Z, Yoon J, Spring DR. ChemInform Abstract: Fluorescent Chemosensors for Zn2+ Cheminform. 41. DOI: 10.1002/chin.201042278 |
0.422 |
|
2010 |
BALDWIN JE, SPRING DR, WHITEHEAD RC. ChemInform Abstract: A Novel Diels-Alder Approach to Hydroisoquinolines. Cheminform. 29: no-no. DOI: 10.1002/chin.199843163 |
0.312 |
|
2004 |
Huang J, Zhu H, Haggarty SJ, Spring DR, Hwang H, Jin F, Snyder M, Schreiber SL. Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proceedings of the National Academy of Sciences of the United States of America. 101: 16594-9. PMID 15539461 DOI: 10.1073/Pnas.0407117101 |
0.609 |
|
2002 |
Spring DR, Krishnan S, Blackwell HE, Schreiber SL. Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform. Journal of the American Chemical Society. 124: 1354-63. PMID 11841305 DOI: 10.1021/Ja017248O |
0.703 |
|
2001 |
Clemons PA, Koehler AN, Wagner BK, Sprigings TG, Spring DR, King RW, Schreiber SL, Foley MA. A one-bead, one-stock solution approach to chemical genetics: part 2. Chemistry & Biology. 8: 1183-95. PMID 11755397 DOI: 10.1016/S1074-5521(01)00086-2 |
0.754 |
|
2000 |
Spring DR, Krishnan S, Schreiber SL. Towards Diversity-Oriented, Stereoselective Syntheses of Biaryl- or Bis(aryl)metal-Containing Medium Rings Journal of the American Chemical Society. 122: 5656-5657. DOI: 10.1021/Ja0010507 |
0.558 |
|
2000 |
Spring DR, Krishnan S, Schreiber SL. ChemInform Abstract: Towards Diversity-Oriented Stereoselective Syntheses of Biaryl- or Bis(aryl)metal-Containing Medium Rings. Cheminform. 31: no-no. DOI: 10.1002/chin.200040155 |
0.345 |
|
1998 |
Baldwin JE, Claridge TDW, Culshaw AJ, Heupel FA, Lee V, Spring DR, Whitehead RC, Boughtflower RJ, Mutton IM, Upton RJ. Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis. Angewandte Chemie (International Ed. in English). 37: 2661-2663. PMID 29711622 DOI: 10.1002/(Sici)1521-3773(19981016)37:19<2661::Aid-Anie2661>3.0.Co;2-D |
0.308 |
|
1998 |
Baldwin JE, Spring DR, Whitehead RC. A novel Diels-Alder approach to hydroisoquinolines Tetrahedron Letters. 39: 5417-5420. DOI: 10.1016/S0040-4039(98)01043-0 |
0.33 |
|
1998 |
Baldwin JE, Spring DR, Atkinson CE, Lee V. Efficient synthesis of the sponge alkaloids cyclostellettamines A-F Tetrahedron. 54: 13655-13680. DOI: 10.1016/S0040-4020(98)00842-4 |
0.325 |
|
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