| Year |
Citation |
Score |
| 2023 |
Purro SA, Farmer M, Noble E, Sarell CJ, Powell M, Yip D, Giggins L, Zakka L, Thomas DX, Farrow M, Nicoll AJ, Walsh D, Collinge J. Two mouse models of Alzheimer's disease accumulate amyloid at different rates and have distinct Aβ oligomer profiles unaltered by ablation of cellular prion protein. Plos One. 18: e0294465. PMID 37976283 DOI: 10.1371/journal.pone.0294465 |
0.451 |
|
| 2023 |
Ondrejcak T, Klyubin I, Hu NW, O'Malley TT, Corbett GT, Winters R, Perkinton MS, Billinton A, Prenderville JA, Walsh DM, Rowan MJ. Tau and Amyloid β Protein in Patient-Derived Aqueous Brain Extracts Act Concomitantly to Disrupt Long-Term Potentiation . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 43: 5870-5879. PMID 37491315 DOI: 10.1523/JNEUROSCI.0082-23.2023 |
0.429 |
|
| 2023 |
Wang Z, Jin M, Hong W, Liu W, Reczek D, Lagomarsino VN, Hu Y, Weeden T, Frosch MP, Young-Pearse TL, Pradier L, Selkoe D, Walsh DM. Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics. Acta Neuropathologica Communications. 11: 39. PMID 36899414 DOI: 10.1186/s40478-023-01511-2 |
0.768 |
|
| 2023 |
Hong W, Liu W, Desousa AO, Young-Pearse T, Walsh DM. Methods for the isolation and analysis of Aβ from postmortem brain. Frontiers in Neuroscience. 17: 1108715. PMID 36777642 DOI: 10.3389/fnins.2023.1108715 |
0.77 |
|
| 2021 |
Mengel D, Mok TH, Nihat A, Liu W, Rissman RA, Galasko D, Zetterberg H, Mead S, Collinge J, Walsh DM. NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression. Cells. 10. PMID 34944022 DOI: 10.3390/cells10123514 |
0.318 |
|
| 2021 |
Podracky CJ, An C, DeSousa A, Dorr BM, Walsh DM, Liu DR. Laboratory evolution of a sortase enzyme that modifies amyloid-β protein. Nature Chemical Biology. PMID 33432237 DOI: 10.1038/s41589-020-00706-1 |
0.314 |
|
| 2020 |
Mengel D, Janelidze S, Glynn RJ, Liu W, Hansson O, Walsh DM. Plasma NT1 Tau is a Specific and Early Marker of Alzheimer's Disease. Annals of Neurology. PMID 32829532 DOI: 10.1002/Ana.25885 |
0.35 |
|
| 2020 |
Walsh DM, Selkoe DJ. Amyloid β-protein and beyond: the path forward in Alzheimer's disease. Current Opinion in Neurobiology. 61: 116-124. PMID 32197217 DOI: 10.1016/j.conb.2020.02.003 |
0.535 |
|
| 2020 |
Mengel D, Liu W, Glynn RJ, Selkoe DJ, Strydom A, Lai F, Rosas HD, Torres A, Patsiogiannis V, Skotko B, Walsh DM. Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase. Alzheimer's Research & Therapy. 12: 27. PMID 32192521 DOI: 10.1186/S13195-020-00593-7 |
0.534 |
|
| 2019 |
Corbett GT, Wang Z, Hong W, Colom-Cadena M, Rose J, Liao M, Asfaw A, Hall TC, Ding L, DeSousa A, Frosch MP, Collinge J, Harris DA, Perkinton MS, Spires-Jones TL, ... ... Walsh DM, et al. PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins. Acta Neuropathologica. PMID 31853635 DOI: 10.1007/S00401-019-02114-9 |
0.749 |
|
| 2019 |
Cha DJ, Mengel D, Mustapic M, Liu W, Selkoe DJ, Kapogiannis D, Galasko D, Rissman RA, Bennett DA, Walsh DM. miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients. Frontiers in Neuroscience. 13: 1208. PMID 31849573 DOI: 10.3389/Fnins.2019.01208 |
0.468 |
|
| 2019 |
Zott B, Simon MM, Hong W, Unger F, Chen-Engerer HJ, Frosch MP, Sakmann B, Walsh DM, Konnerth A. A vicious cycle of β amyloid-dependent neuronal hyperactivation. Science (New York, N.Y.). 365: 559-565. PMID 31395777 DOI: 10.1126/Science.Aay0198 |
0.588 |
|
| 2019 |
Yang T, Dang Y, Ostaszewski B, Mengel D, Steffen V, Rabe C, Bittner T, Walsh DM, Selkoe DJ. Target Engagement in an Alzheimer Trial: Crenezumab Lowers Aβ Oligomers in CSF. Annals of Neurology. PMID 31168802 DOI: 10.1002/ana.25513 |
0.603 |
|
| 2019 |
Brinkmalm G, Hong W, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM. Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain. Brain : a Journal of Neurology. 142: 1441-1457. PMID 31032851 DOI: 10.1093/Brain/Awz066 |
0.662 |
|
| 2019 |
Ondrejcak T, Hu NW, Qi Y, Klyubin I, Corbett GT, Fraser G, Perkinton MS, Walsh DM, Billinton A, Rowan MJ. Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo. Neurobiology of Disease. PMID 30910746 DOI: 10.1016/J.Nbd.2019.03.022 |
0.36 |
|
| 2018 |
Mengel D, Hong W, Corbett GT, Liu W, DeSousa A, Solforosi L, Fang C, Frosch MP, Collinge J, Harris D, Walsh DM. PrP-grafted antibodies bind certain amyloid β-protein aggregates, but do not prevent toxicity. Brain Research. PMID 30593771 DOI: 10.1016/J.Brainres.2018.12.038 |
0.496 |
|
| 2018 |
Purro SA, Farrow MA, Linehan J, Nazari T, Thomas DX, Chen Z, Mengel D, Saito T, Saido T, Rudge P, Brandner S, Walsh DM, Collinge J. Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone. Nature. PMID 30546139 DOI: 10.1038/S41586-018-0790-Y |
0.742 |
|
| 2018 |
Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, ... ... Walsh DM, et al. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30419228 DOI: 10.1016/J.Jalz.2018.09.010 |
0.736 |
|
| 2018 |
Ondrejcak T, Klyubin I, Corbett GT, Fraser G, Hong W, Mably AJ, Gardener M, Hammersley J, Perkinton MS, Billinton A, Walsh DM, Rowan MJ. Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30355631 DOI: 10.1523/Jneurosci.1700-18.2018 |
0.58 |
|
| 2018 |
Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM. An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease. Nature Communications. 9: 2676. PMID 29992960 DOI: 10.1038/S41467-018-05068-W |
0.797 |
|
| 2018 |
El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathologica. PMID 29982852 DOI: 10.1007/S00401-018-1880-5 |
0.706 |
|
| 2018 |
Hu NW, Corbett GT, Moore S, Klyubin I, O'Malley TT, Walsh DM, Livesey FJ, Rowan MJ. Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity. Cell Reports. 23: 1932-1938. PMID 29768194 DOI: 10.1016/J.Celrep.2018.04.040 |
0.427 |
|
| 2018 |
O'Malley TT, Linse S, Walsh DM. Production and Use of Recombinant Aβ for Aggregation Studies. Methods in Molecular Biology (Clifton, N.J.). 1777: 307-320. PMID 29744844 DOI: 10.1007/978-1-4939-7811-3_19 |
0.453 |
|
| 2018 |
Hong W, Wang Z, Liu W, O'Malley TT, Jin M, Willem M, Haass C, Frosch MP, Walsh DM. Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain. Acta Neuropathologica. PMID 29687257 DOI: 10.1007/S00401-018-1846-7 |
0.694 |
|
| 2018 |
Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM. Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. International Journal of Molecular Sciences. 19. PMID 29495441 DOI: 10.3390/Ijms19030663 |
0.805 |
|
| 2018 |
OMalley TT, Walsh DM. Lessons from the Study of Covalent Dimers of the Alzheimer’s Disease-Associate Amyloid β-Protein Biochemistry & Physiology: Open Access. 7. DOI: 10.4172/2168-9652.1000229 |
0.308 |
|
| 2017 |
Sarell CJ, Quarterman E, Yip DC, Terry C, Nicoll AJ, Wadsworth JDF, Farrow MA, Walsh DM, Collinge J. Soluble Aβ aggregates can inhibit prion propagation. Open Biology. 7. PMID 29142106 DOI: 10.1098/Rsob.170158 |
0.42 |
|
| 2017 |
Wang Z, Jackson RJ, Hong W, Taylor WM, Corbett GT, Moreno A, Liu W, Li S, Frosch MP, Slutsky I, Young-Pearse T, Spires-Jones TL, Walsh DM. Human brain-derived Aβ oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29101243 DOI: 10.1523/Jneurosci.2009-17.2017 |
0.769 |
|
| 2017 |
Yang T, Li S, Xu H, Walsh DM, Selkoe DJ. Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 37: 152-163. PMID 28053038 DOI: 10.1523/JNEUROSCI.1698-16.2016 |
0.795 |
|
| 2016 |
O'Malley TT, Wittbold WM, Linse S, Walsh DM. The aggregation paths and products of Aβ42 dimers are distinct from Aβ42 monomer. Biochemistry. PMID 27750419 DOI: 10.1021/acs.biochem.6b00453 |
0.431 |
|
| 2016 |
Pickett EK, Koffie RM, Wegmann S, Henstridge CM, Herrmann AG, Colom-Cadena M, Lleo A, Kay KR, Vaught M, Soberman R, Walsh DM, Hyman BT, Spires-Jones TL. Non-Fibrillar Oligomeric Amyloid-β within Synapses. Journal of Alzheimer's Disease : Jad. PMID 27258414 DOI: 10.3233/Jad-160007 |
0.437 |
|
| 2016 |
Walsh DM, Selkoe DJ. A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nature Reviews. Neuroscience. 17: 251-60. PMID 26988744 DOI: 10.1038/nrn.2016.13 |
0.48 |
|
| 2015 |
Szczepankiewicz O, Linse B, Meisl G, Thulin E, Frohm B, Sala Frigerio C, Colvin MT, Jacavone AC, Griffin RG, Knowles TP, Walsh DM, Linse S. N-terminal extensions retard Aβ42 fibril formation but allow cross-seeding and co-aggregation with Aβ42. Journal of the American Chemical Society. PMID 26535489 DOI: 10.1021/Jacs.5B07849 |
0.433 |
|
| 2015 |
Lei M, Xu H, Li Z, Wang Z, O'Malley TT, Zhang D, Walsh DM, Xu P, Selkoe DJ, Li S. Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance. Neurobiology of Disease. 85: 111-121. PMID 26525100 DOI: 10.1016/J.Nbd.2015.10.019 |
0.75 |
|
| 2015 |
Keaney J, Walsh DM, O'Malley T, Hudson N, Crosbie DE, Loftus T, Sheehan F, McDaid J, Humphries MM, Callanan JJ, Brett FM, Farrell MA, Humphries P, Campbell M. Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier. Science Advances. 1: e1500472. PMID 26491725 DOI: 10.1126/Sciadv.1500472 |
0.371 |
|
| 2015 |
Cantlon A, Frigerio CS, Walsh DM. Lessons from a Rare Familial Dementia: Amyloid and Beyond. Journal of Parkinson's Disease and Alzheimer's Disease. 2. PMID 26405694 DOI: 10.13188/2376-922X.1000009 |
0.474 |
|
| 2015 |
Phay M, Welzel AT, Williams AD, McWilliams-Koeppen HP, Blinder V, O'Malley TT, Solomon A, Walsh DM, O'Nuallain B. IgG Conformer's Binding to Amyloidogenic Aggregates. Plos One. 10: e0137344. PMID 26367058 DOI: 10.1371/journal.pone.0137344 |
0.357 |
|
| 2015 |
Loynachan CN, Romero G, Christiansen MG, Chen R, Ellison R, O'Malley TT, Froriep UP, Walsh DM, Anikeeva P. Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid-β Aggregates. Advanced Healthcare Materials. PMID 26288378 DOI: 10.1002/Adhm.201500487 |
0.358 |
|
| 2015 |
Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM. C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10851-65. PMID 26224867 DOI: 10.1523/Jneurosci.0387-15.2015 |
0.73 |
|
| 2015 |
Mably AJ, Liu W, Mc Donald JM, Dodart JC, Bard F, Lemere CA, O'Nuallain B, Walsh DM. Anti-Aβ antibodies incapable of reducing cerebral Aβ oligomers fail to attenuate spatial reference memory deficits in J20 mice. Neurobiology of Disease. 82: 372-384. PMID 26215784 DOI: 10.1016/j.nbd.2015.07.008 |
0.404 |
|
| 2015 |
Guan Y, Cao KJ, Cantlon A, Elbel K, Theodorakis EA, Walsh DM, Yang J, Shah JV. Real-Time Monitoring of Alzheimer's-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy. Acs Chemical Neuroscience. PMID 26212450 DOI: 10.1021/Acschemneuro.5B00176 |
0.376 |
|
| 2015 |
Cantlon A, Frigerio CS, Freir DB, Boland B, Jin M, Walsh DM. The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers. The Journal of Biological Chemistry. 290: 16502-16. PMID 25957407 DOI: 10.1074/jbc.M115.652263 |
0.424 |
|
| 2015 |
Levites Y, O'Nuallain B, Puligedda RD, Ondrejcak T, Adekar SP, Chen C, Cruz PE, Rosario AM, Macy S, Mably AJ, Walsh DM, Vidal R, Solomon A, Brown D, Rowan MJ, et al. A human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6265-76. PMID 25904780 DOI: 10.1523/Jneurosci.5109-14.2015 |
0.452 |
|
| 2015 |
Mc Donald JM, O'Malley TT, Liu W, Mably AJ, Brinkmalm G, Portelius E, Wittbold WM, Frosch MP, Walsh DM. The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 25846299 DOI: 10.1016/J.Jalz.2015.01.005 |
0.424 |
|
| 2015 |
Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ. A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid. Alzheimer's Research & Therapy. 7: 14. PMID 25802556 DOI: 10.1186/S13195-015-0100-Y |
0.522 |
|
| 2015 |
Mably AJ, Kanmert D, Mc Donald JM, Liu W, Caldarone BJ, Lemere CA, O'Nuallain B, Kosik KS, Walsh DM. Tau immunization: a cautionary tale? Neurobiology of Aging. 36: 1316-32. PMID 25619661 DOI: 10.1016/j.neurobiolaging.2014.11.022 |
0.59 |
|
| 2015 |
Loynachan CN, Romero G, Christiansen MG, Chen R, Ellison R, O'Malley TT, Froriep UP, Walsh DM, Anikeeva P. Alzheimer's Disease: Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid-β Aggregates (Adv. Healthcare Mater. 14/2015) Advanced Healthcare Materials. 4: 2049-2049. DOI: 10.1002/Adhm.201570081 |
0.314 |
|
| 2014 |
Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ. Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity. Biochemistry. 53: 3908-21. PMID 24840308 DOI: 10.1021/Bi5003053 |
0.584 |
|
| 2014 |
Fogel H, Frere S, Segev O, Bharill S, Shapira I, Gazit N, O'Malley T, Slomowitz E, Berdichevsky Y, Walsh DM, Isacoff EY, Hirsch JA, Slutsky I. APP homodimers transduce an amyloid-β-mediated increase in release probability at excitatory synapses. Cell Reports. 7: 1560-76. PMID 24835997 DOI: 10.1016/J.Celrep.2014.04.024 |
0.404 |
|
| 2014 |
Klyubin I, Nicoll AJ, Khalili-Shirazi A, Farmer M, Canning S, Mably A, Linehan J, Brown A, Wakeling M, Brandner S, Walsh DM, Rowan MJ, Collinge J. Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aβ synaptotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6140-5. PMID 24790184 DOI: 10.1523/Jneurosci.3526-13.2014 |
0.394 |
|
| 2014 |
Mittag JJ, Milani S, Walsh DM, Rädler JO, McManus JJ. Simultaneous measurement of a range of particle sizes during Aβ1-42 fibrillogenesis quantified using fluorescence correlation spectroscopy. Biochemical and Biophysical Research Communications. 448: 195-9. PMID 24769478 DOI: 10.1016/j.bbrc.2014.04.088 |
0.411 |
|
| 2014 |
Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL. The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Human Molecular Genetics. 23: 3523-36. PMID 24524897 DOI: 10.1093/Hmg/Ddu064 |
0.817 |
|
| 2014 |
Métais C, Brennan K, Mably AJ, Scott M, Walsh DM, Herron CE. Simvastatin treatment preserves synaptic plasticity in AβPPswe/PS1dE9 mice. Journal of Alzheimer's Disease : Jad. 39: 315-29. PMID 24164738 DOI: 10.3233/JAD-130257 |
0.443 |
|
| 2014 |
Phay M, Blinder V, Macy S, Greene MJ, Wooliver DC, Liu W, Planas A, Walsh DM, Connors LH, Primmer SR, Planque SA, Paul S, O'Nuallain B. Transthyretin aggregate-specific antibodies recognize cryptic epitopes on patient-derived amyloid fibrils. Rejuvenation Research. 17: 97-104. PMID 24164623 DOI: 10.1089/Rej.2013.1524 |
0.369 |
|
| 2014 |
O'Nuallain B, Blinder V, Kanmert D, O'Malley T, Mably A, Frost J, Vanderburgh CR, Lemere CA, Walsh D. Are Anti-Abeta Aggregate-Preferring Antibodies The Future For Ad Immunotherapy? Alzheimers & Dementia. 10. DOI: 10.1016/J.Jalz.2014.07.035 |
0.464 |
|
| 2014 |
Cukalevski R, Yang X, Cohen S, Boland B, Frohm B, Thulin E, Walsh D, Knowles T, Linse S. Amyloid β-Protein: The Influence of Intrinsic and Extrinsic Factors on Fibril Formation Biophysical Journal. 106: 682a-683a. DOI: 10.1016/J.Bpj.2013.11.3778 |
0.503 |
|
| 2013 |
An K, Klyubin I, Kim Y, Jung JH, Mably AJ, O'Dowd ST, Lynch T, Kanmert D, Lemere CA, Finan GM, Park JW, Kim TW, Walsh DM, Rowan MJ, Kim JH. Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo. Molecular Brain. 6: 47. PMID 24284042 DOI: 10.1186/1756-6606-6-47 |
0.571 |
|
| 2013 |
Nicoll AJ, Panico S, Freir DB, Wright D, Terry C, Risse E, Herron CE, O'Malley T, Wadsworth JD, Farrow MA, Walsh DM, Saibil HR, Collinge J. Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity. Nature Communications. 4: 2416. PMID 24022506 DOI: 10.1038/Ncomms3416 |
0.341 |
|
| 2013 |
Yang T, Hong S, O'Malley T, Sperling RA, Walsh DM, Selkoe DJ. New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 99-112. PMID 23375565 DOI: 10.1016/J.Jalz.2012.11.005 |
0.695 |
|
| 2013 |
Borlikova GG, Trejo M, Mably AJ, Mc Donald JM, Sala Frigerio C, Regan CM, Murphy KJ, Masliah E, Walsh DM. Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation. Neurobiology of Aging. 34: 1315-27. PMID 23182244 DOI: 10.1016/J.Neurobiolaging.2012.10.028 |
0.329 |
|
| 2013 |
O'Dowd ST, Ardah MT, Johansson P, Lomakin A, Benedek GB, Roberts KA, Cummins G, El Agnaf OM, Svensson J, Zetterberg H, Lynch T, Walsh DM. The ELISA-measured increase in cerebrospinal fluid tau that discriminates Alzheimer's disease from other neurodegenerative disorders is not attributable to differential recognition of tau assembly forms. Journal of Alzheimer's Disease : Jad. 33: 923-8. PMID 23034520 DOI: 10.3233/Jad-2012-121393 |
0.391 |
|
| 2012 |
Cukalevski R, Boland B, Frohm B, Thulin E, Walsh D, Linse S. Role of aromatic side chains in amyloid β-protein aggregation. Acs Chemical Neuroscience. 3: 1008-16. PMID 23259036 DOI: 10.1021/Cn300073S |
0.418 |
|
| 2012 |
Welzel AT, Williams AD, McWilliams-Koeppen HP, Acero L, Weber A, Blinder V, Mably A, Bunk S, Hermann C, Farrell MA, Ehrlich HJ, Schwarz HP, Walsh DM, Solomon A, O'Nuallain B. Human anti-Aβ IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide. Plos One. 7: e50317. PMID 23209707 DOI: 10.1371/journal.pone.0050317 |
0.427 |
|
| 2012 |
Moro ML, Giaccone G, Lombardi R, Indaco A, Uggetti A, Morbin M, Saccucci S, Di Fede G, Catania M, Walsh DM, Demarchi A, Rozemuller A, Bogdanovic N, Bugiani O, Ghetti B, et al. APP mutations in the Aβ coding region are associated with abundant cerebral deposition of Aβ38. Acta Neuropathologica. 124: 809-21. PMID 23143229 DOI: 10.1007/S00401-012-1061-X |
0.365 |
|
| 2012 |
Walsh DM, Teplow DB. Alzheimer's disease and the amyloid β-protein. Progress in Molecular Biology and Translational Science. 107: 101-24. PMID 22482449 DOI: 10.1016/B978-0-12-385883-2.00012-6 |
0.321 |
|
| 2012 |
McDonald JM, Cairns NJ, Taylor-Reinwald L, Holtzman D, Walsh DM. The levels of water-soluble and triton-soluble Aβ are increased in Alzheimer's disease brain. Brain Research. 1450: 138-47. PMID 22440675 DOI: 10.1016/J.Brainres.2012.02.041 |
0.344 |
|
| 2012 |
Nicholson AM, Wold LA, Walsh DM, Ferreira A. β-Amyloid carrying the Dutch mutation has diverse effects on calpain-mediated toxicity in hippocampal neurons. Molecular Medicine (Cambridge, Mass.). 18: 178-85. PMID 22160219 DOI: 10.2119/Molmed.2011.00366 |
0.41 |
|
| 2012 |
Bieschke J, Herbst M, Wiglenda T, Friedrich RP, Boeddrich A, Schiele F, Kleckers D, Lopez del Amo JM, Grüning BA, Wang Q, Schmidt MR, Lurz R, Anwyl R, Schnoegl S, Fändrich M, ... ... Walsh DM, et al. Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils. Nature Chemical Biology. 8: 93-101. PMID 22101602 DOI: 10.1038/Nchembio.719 |
0.4 |
|
| 2012 |
Walsh D. 82 Getting to grips with water-soluble brain-derived Aβ dimers Neurobiology of Aging. 33. DOI: 10.1016/J.Neurobiolaging.2012.01.100 |
0.363 |
|
| 2012 |
Klyubin I, Mably A, Minogue A, Hu N, Farrell M, Walsh D, Rowan M. Alzheimer's disease human brain beta-amyloid-containing extracts inhibit hippocampal long-term potentiation in rats in vivo: Relationship between soluble and insoluble preparations Alzheimers & Dementia. 8: 648. DOI: 10.1016/J.Jalz.2012.05.1735 |
0.446 |
|
| 2011 |
O'Nuallain B, Klyubin I, Mc Donald JM, Foster JS, Welzel A, Barry A, Dykoski RK, Cleary JP, Gebbink MF, Rowan MJ, Walsh DM. A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ. Journal of Neurochemistry. 119: 189-201. PMID 21781116 DOI: 10.1111/j.1471-4159.2011.07389.x |
0.349 |
|
| 2011 |
Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J. Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites. Nature Communications. 2: 336. PMID 21654636 DOI: 10.1038/Ncomms1341 |
0.348 |
|
| 2011 |
Barry AE, Klyubin I, Mc Donald JM, Mably AJ, Farrell MA, Scott M, Walsh DM, Rowan MJ. Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7259-63. PMID 21593310 DOI: 10.1523/JNEUROSCI.6500-10.2011 |
0.342 |
|
| 2011 |
Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, Wüllner U, Glebov K, Heneka MT, Walsh DM, Zweckstetter M, Walter J. Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease. The Embo Journal. 30: 2255-65. PMID 21527912 DOI: 10.1038/Emboj.2011.138 |
0.451 |
|
| 2011 |
Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proceedings of the National Academy of Sciences of the United States of America. 108: 5819-24. PMID 21421841 DOI: 10.1073/Pnas.1017033108 |
0.666 |
|
| 2011 |
Shankar GM, Welzel AT, McDonald JM, Selkoe DJ, Walsh DM. Isolation of low-n amyloid β-protein oligomers from cultured cells, CSF, and brain. Methods in Molecular Biology (Clifton, N.J.). 670: 33-44. PMID 20967581 DOI: 10.1007/978-1-60761-744-0_3 |
0.523 |
|
| 2011 |
Welzel AT, Walsh DM. Aberrant protein structure and diseases of the brain. Irish Journal of Medical Science. 180: 15-22. PMID 20960238 DOI: 10.1007/s11845-010-0606-z |
0.308 |
|
| 2011 |
Freir DB, Fedriani R, Scully D, Smith IM, Selkoe DJ, Walsh DM, Regan CM. Aβ oligomers inhibit synapse remodelling necessary for memory consolidation. Neurobiology of Aging. 32: 2211-8. PMID 20097446 DOI: 10.1016/J.Neurobiolaging.2010.01.001 |
0.464 |
|
| 2010 |
Hellstrand E, Boland B, Walsh DM, Linse S. Amyloid β-protein aggregation produces highly reproducible kinetic data and occurs by a two-phase process. Acs Chemical Neuroscience. 1: 13-8. PMID 22778803 DOI: 10.1021/cn900015v |
0.37 |
|
| 2010 |
O'Nuallain B, Freir DB, Nicoll AJ, Risse E, Ferguson N, Herron CE, Collinge J, Walsh DM. Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14411-9. PMID 20980598 DOI: 10.1523/Jneurosci.3537-10.2010 |
0.395 |
|
| 2010 |
Boland B, Smith DA, Mooney D, Jung SS, Walsh DM, Platt FM. Macroautophagy is not directly involved in the metabolism of amyloid precursor protein. The Journal of Biological Chemistry. 285: 37415-26. PMID 20864542 DOI: 10.1074/jbc.M110.186411 |
0.369 |
|
| 2010 |
Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM. The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain : a Journal of Neurology. 133: 1328-41. PMID 20403962 DOI: 10.1093/Brain/Awq065 |
0.554 |
|
| 2010 |
Sala Frigerio C, Fadeeva JV, Minogue AM, Citron M, Van Leuven F, Staufenbiel M, Paganetti P, Selkoe DJ, Walsh DM. beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. The Febs Journal. 277: 1503-18. PMID 20163459 DOI: 10.1111/j.1742-4658.2010.07579.x |
0.54 |
|
| 2010 |
Hampel H, Shen Y, Walsh DM, Aisen P, Shaw LM, Zetterberg H, Trojanowski JQ, Blennow K. Biological markers of amyloid beta-related mechanisms in Alzheimer's disease. Experimental Neurology. 223: 334-46. PMID 19815015 DOI: 10.1016/J.Expneurol.2009.09.024 |
0.409 |
|
| 2009 |
Shankar GM, Walsh DM. Alzheimer's disease: synaptic dysfunction and Abeta. Molecular Neurodegeneration. 4: 48. PMID 19930651 DOI: 10.1186/1750-1326-4-48 |
0.438 |
|
| 2009 |
Sala Frigerio C, Kukar TL, Fauq A, Engel PC, Golde TE, Walsh DM. An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1. Biochemistry. 48: 10894-904. PMID 19821615 DOI: 10.1021/Bi901237K |
0.327 |
|
| 2009 |
Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiology of Disease. 36: 293-302. PMID 19660551 DOI: 10.1016/J.Nbd.2009.07.021 |
0.558 |
|
| 2009 |
Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, Selkoe D. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron. 62: 788-801. PMID 19555648 DOI: 10.1016/J.Neuron.2009.05.012 |
0.693 |
|
| 2009 |
Minogue AM, Stubbs AK, Frigerio CS, Boland B, Fadeeva JV, Tang J, Selkoe DJ, Walsh DM. gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons. Brain Research. 1262: 89-99. PMID 19401174 DOI: 10.1016/J.Brainres.2009.01.008 |
0.575 |
|
| 2009 |
Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ. A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Archives of Neurology. 66: 190-9. PMID 19204155 DOI: 10.1001/Archneurol.2008.565 |
0.55 |
|
| 2009 |
Walsh DM, Thulin E, Minogue AM, Gustavsson N, Pang E, Teplow DB, Linse S. A facile method for expression and purification of the Alzheimer's disease-associated amyloid beta-peptide. The Febs Journal. 276: 1266-81. PMID 19175671 DOI: 10.1111/J.1742-4658.2008.06862.X |
0.353 |
|
| 2008 |
O'Shea SD, Smith IM, McCabe OM, Cronin MM, Walsh DM, O'Connor WT. Intracerebroventricular Administration of Amyloid β-protein Oligomers Selectively Increases Dorsal Hippocampal Dialysate Glutamate Levels in the Awake Rat. Sensors (Basel, Switzerland). 8: 7428-7437. PMID 27873937 DOI: 10.3390/s8117428 |
0.403 |
|
| 2008 |
Hu NW, Smith IM, Walsh DM, Rowan MJ. Soluble amyloid-beta peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo. Brain : a Journal of Neurology. 131: 2414-24. PMID 18678563 DOI: 10.1093/brain/awn174 |
0.382 |
|
| 2008 |
Betts V, Leissring MA, Dolios G, Wang R, Selkoe DJ, Walsh DM. Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin. Neurobiology of Disease. 31: 442-50. PMID 18602473 DOI: 10.1016/J.Nbd.2008.06.001 |
0.514 |
|
| 2008 |
Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nature Medicine. 14: 837-42. PMID 18568035 DOI: 10.1038/Nm1782 |
0.602 |
|
| 2008 |
Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, ... ... Walsh DM, et al. Substrate-targeting gamma-secretase modulators. Nature. 453: 925-9. PMID 18548070 DOI: 10.1038/Nature07055 |
0.605 |
|
| 2008 |
Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ. Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4231-7. PMID 18417702 DOI: 10.1523/Jneurosci.5161-07.2008 |
0.58 |
|
| 2008 |
Irvine GB, El-Agnaf OM, Shankar GM, Walsh DM. Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases. Molecular Medicine (Cambridge, Mass.). 14: 451-64. PMID 18368143 DOI: 10.2119/2007-00100.Irvine |
0.35 |
|
| 2008 |
Xia W, Yang T, Smith IM, Walsh DM, Selkoe DJ. P1-368: Monomeric and oligmeric Aβ assays on plasma of Alzheimer patients Alzheimer's & Dementia. 4: T327-T327. DOI: 10.1016/j.jalz.2008.05.950 |
0.492 |
|
| 2008 |
McDonald JM, Brayne C, Savva G, Mattews FE, Welzel A, Shankar GM, Ince PG, Selkoe DJ, Walsh DM. P3-415: The presence of Abeta dimers in soluble brain extract is associated with dementia Alzheimer's & Dementia. 4: T643-T643. DOI: 10.1016/J.Jalz.2008.05.1986 |
0.471 |
|
| 2008 |
Walsh DM. S1-02-03: Synthetic Abeta dimers and Abeta dimers from CSF and Alzheimer brain disrupt synaptic plasticity and memory Alzheimer's & Dementia. 4: T101-T102. DOI: 10.1016/j.jalz.2008.05.192 |
0.346 |
|
| 2008 |
Kukar TL, Ladd TB, Bann MA, Fraering PC, Maharvi GM, Moore B, Rangachari V, Welzel A, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, ... ... Walsh D, et al. P2-338: Substrate-targeting gamma-secretase modulators Alzheimer's & Dementia. 4: T472-T472. DOI: 10.1016/J.Jalz.2008.05.1415 |
0.492 |
|
| 2007 |
Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. The American Journal of Pathology. 171: 241-51. PMID 17591969 DOI: 10.2353/Ajpath.2007.070105 |
0.582 |
|
| 2007 |
Walsh DM, Minogue AM, Sala Frigerio C, Fadeeva JV, Wasco W, Selkoe DJ. The APP family of proteins: similarities and differences. Biochemical Society Transactions. 35: 416-20. PMID 17371289 DOI: 10.1042/Bst0350416 |
0.559 |
|
| 2007 |
Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2866-75. PMID 17360908 DOI: 10.1523/Jneurosci.4970-06.2007 |
0.579 |
|
| 2007 |
Walsh DM, Selkoe DJ. A beta oligomers - a decade of discovery. Journal of Neurochemistry. 101: 1172-84. PMID 17286590 DOI: 10.1111/j.1471-4159.2006.04426.x |
0.505 |
|
| 2007 |
Herbst M, Bieschke J, Wang Q, Lurz R, Boeddrich A, Otto A, Anwyl R, Walsh D, Wanker E. Induction of fibril-like beta-amyloid aggregates by a natural substance decreases soluble oligomers and protects from neurotoxicity Aktuelle Neurologie. 34. DOI: 10.1055/s-2007-987948 |
0.332 |
|
| 2006 |
Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, et al. Common threads in neurodegenerative disorders of aging. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 322-6. PMID 19595906 DOI: 10.1016/J.Jalz.2006.08.008 |
0.359 |
|
| 2006 |
Townsend M, Cleary JP, Mehta T, Hofmeister J, Lesne S, O'Hare E, Walsh DM, Selkoe DJ. Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers. Annals of Neurology. 60: 668-76. PMID 17192927 DOI: 10.1002/Ana.21051 |
0.553 |
|
| 2006 |
Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret JM, Paganetti P, Walsh DM, Mathews PM, Ghiso J, et al. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science (New York, N.Y.). 313: 1781-4. PMID 16990547 DOI: 10.1126/Science.1131864 |
0.371 |
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| 2006 |
Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. The Journal of Physiology. 572: 477-92. PMID 16469784 DOI: 10.1113/Jphysiol.2005.103754 |
0.573 |
|
| 2006 |
Keshavan A, Mengel D, Chen Z, Patel PP, Billinton A, Perkinton M, Percival-Alwyn JL, Zetterberg H, Johnson KA, Properzi M, Schultz AP, Sperling RA, Rissman RA, Galasko DR, Schott JM, ... Walsh DM, et al. P1-301: CERTAIN PLASMA N-TERMINAL TAU FRAGMENTS ARE ELEVATED IN AD AND AD-MCI COMPARED TO CONTROLS Alzheimer's & Dementia. 14: P405-P405. DOI: 10.1016/J.Jalz.2018.06.308 |
0.683 |
|
| 2006 |
Walsh DM, Jin M, Wang Z, Liu W, Lagomarsino V, Weeden T, Reczek D, Young-Pearse T, Pradier L, Selkoe DJ. P1-106: A HEAD-TO-HEAD COMPARISON OF LEAD CLINICAL ANTI-Aβ ANTIBODIES Alzheimer's & Dementia. 14: P312-P312. DOI: 10.1016/J.Jalz.2018.06.109 |
0.667 |
|
| 2006 |
Betts V, Leissring MA, Selkoe DJ, Walsh DM. P1-391: Monomeric Aβ peptides bearing the Flemish A21G mutation are less readily degraded by neprilysin than wild type Aβ Alzheimer's & Dementia. 2: S212-S213. DOI: 10.1016/J.Jalz.2006.05.769 |
0.479 |
|
| 2006 |
Minogue AM, Fadeeva JV, Tang J, Wasco W, Selkoe DJ, Walsh DM. P3-352: APLP1-derived peptides do not undergo rapid fibrillogenesis Alzheimer's & Dementia. 2: S478-S478. DOI: 10.1016/J.Jalz.2006.05.1622 |
0.354 |
|
| 2006 |
Selkoe D, Townsend M, Shankar G, Mehta T, Podlisny M, Walsh D. S1-02-04: Role of AB oligomers in AD Alzheimer's & Dementia. 2: S4-S4. DOI: 10.1016/J.Jalz.2006.05.016 |
0.579 |
|
| 2005 |
Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe KH, Rowan MJ, Selkoe DJ. The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention. Biochemical Society Transactions. 33: 1087-90. PMID 16246051 DOI: 10.1042/Bst20051087 |
0.584 |
|
| 2005 |
Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nature Medicine. 11: 556-61. PMID 15834427 DOI: 10.1038/Nm1234 |
0.563 |
|
| 2005 |
Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ. Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2455-62. PMID 15758153 DOI: 10.1523/Jneurosci.4391-04.2005 |
0.58 |
|
| 2005 |
Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nature Neuroscience. 8: 79-84. PMID 15608634 DOI: 10.1038/Nn1372 |
0.474 |
|
| 2004 |
Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron. 44: 181-93. PMID 15450169 DOI: 10.1016/j.neuron.2004.09.010 |
0.479 |
|
| 2004 |
Ye C, Walsh DM, Selkoe DJ, Hartley DM. Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation. Neuroscience Letters. 366: 320-5. PMID 15288443 DOI: 10.1016/j.neulet.2004.05.060 |
0.538 |
|
| 2004 |
Walsh DM, Selkoe DJ. Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration. Protein and Peptide Letters. 11: 213-28. PMID 15182223 DOI: 10.2174/0929866043407174 |
0.589 |
|
| 2004 |
Klyubin I, Walsh DM, Cullen WK, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ. Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo. The European Journal of Neuroscience. 19: 2839-46. PMID 15147317 DOI: 10.1111/j.1460-9568.2004.03389.x |
0.449 |
|
| 2004 |
Wang Q, Walsh DM, Rowan MJ, Selkoe DJ, Anwyl R. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3370-8. PMID 15056716 DOI: 10.1523/JNEUROSCI.1633-03.2004 |
0.471 |
|
| 2004 |
Klyubin I, Walsh DM, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ. P2-004 Anti-Aβ antibodies prevention block of long-term potentiation in the CA1 area of rat hippocampus in vivo by naturally produced Aβ oligomers Neurobiology of Aging. 25: S224-S225. DOI: 10.1016/S0197-4580(04)80752-8 |
0.474 |
|
| 2004 |
Walsh DM, Kylubin I, Cleary JP, Townsend TM, Shankar GM, Podlisny MB, Fadeeva JV, Anwyl R, Ashe KH, Rowan MJ, Selkoe DJ. P1-230 Natural, cell-derived Aβ oligomers: their production, biological activity and inhibition Neurobiology of Aging. 25: S161-S162. DOI: 10.1016/S0197-4580(04)80543-8 |
0.456 |
|
| 2004 |
Fadeeva JV, Walsh DM, Tang J, Luo Y, Citron M, Wasco W, Selkoe DJ. P1-218 Generation of the intracellular C-terminal domain of the APP family of proteins does not require β-secretase Neurobiology of Aging. 25: S158. DOI: 10.1016/S0197-4580(04)80531-1 |
0.408 |
|
| 2004 |
Townsend M, Podlisny M, Shankar G, Fadeeva J, Walsh D, Selkoe D. O4-03-04 Reversal of AB induced LTP deficits by compounds that inhibit AB oligomerization Neurobiology of Aging. 25: S78-S79. DOI: 10.1016/S0197-4580(04)80267-7 |
0.43 |
|
| 2003 |
Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 40: 1087-93. PMID 14687544 DOI: 10.1016/S0896-6273(03)00787-6 |
0.603 |
|
| 2003 |
Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry. 42: 6664-73. PMID 12779321 DOI: 10.1021/Bi027375C |
0.789 |
|
| 2003 |
Kimberly WT, Kovacs DM, Walsh D, Lashuel H, Lemere CA. The 8th International Conference on Alzheimer's Disease and Related Disorders, July 20-25, 2002, Stockholm, Sweden. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 10: 51-61. PMID 12762144 DOI: 10.3109/13506120308995259 |
0.619 |
|
| 2003 |
Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron. 37: 583-95. PMID 12597857 DOI: 10.1016/S0896-6273(03)00024-2 |
0.423 |
|
| 2003 |
Walsh D, Hartley D, Selkoe D. The Many Faces of Aβ: Structures and Activity Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents. 3: 277-291. DOI: 10.2174/1568013033483311 |
0.311 |
|
| 2002 |
Walsh DM, Klyubin I, Fadeeva JV, Rowan MJ, Selkoe DJ. Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochemical Society Transactions. 30: 552-7. PMID 12196135 DOI: 10.1042/BST0300552 |
0.498 |
|
| 2002 |
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 416: 535-9. PMID 11932745 DOI: 10.1038/416535a |
0.591 |
|
| 2002 |
Walsh DM, Kylubin I, Fadeeva JV, Rowan MJ, Selkoe DJ. Cell-derived Aβ oligomers: production, activity and inhibition Biochemical Society Transactions. 30: A56-A56. DOI: 10.1042/bst030a056 |
0.468 |
|
| 2001 |
Walsh DM, Hartley DM, Condron MM, Selkoe DJ, Teplow DB. In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease. The Biochemical Journal. 355: 869-77. PMID 11311152 DOI: 10.1042/Bj3550869 |
0.574 |
|
| 2000 |
Fezoui Y, Hartley DM, Walsh DM, Selkoe DJ, Osterhout JJ, Teplow DB. A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils. Nature Structural Biology. 7: 1095-9. PMID 11101888 DOI: 10.1038/81937 |
0.443 |
|
| 2000 |
Fezoui Y, Hartley DM, Harper JD, Khurana R, Walsh DM, Condron MM, Selkoe DJ, Lansbury PT, Fink AL, Teplow DB. An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 7: 166-78. PMID 11019857 DOI: 10.3109/13506120009146831 |
0.407 |
|
| 2000 |
Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ. The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry. 39: 10831-9. PMID 10978169 DOI: 10.1021/bi001048s |
0.538 |
|
| 2000 |
Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme The Journal of Neuroscience. 20: 1657-1665. DOI: 10.1523/Jneurosci.20-05-01657.2000 |
0.611 |
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| 2000 |
Fezoui Y, Hartley DM, Walsh DM, Selkoe DJ, Osterhut JJ, Teplow DB. A de novo designed α-helical peptide forms amyloid fibrils which are not neurotoxic Neurobiology of Aging. 21: 77. DOI: 10.1016/S0197-4580(00)82568-3 |
0.458 |
|
| 2000 |
Selkoe DJ, Xia W, Taylor Kimberly W, Vekrellis K, Walsh D, Wolfe MS. Molecular basis of presenilin's role in APP processing Neurobiology of Aging. 21: 70. DOI: 10.1016/S0197-4580(00)82534-8 |
0.488 |
|
| 1999 |
Walsh DM, Hartley DM, Kusumoto Y, Fezoui Y, Condron MM, Lomakin A, Benedek GB, Selkoe DJ, Teplow DB. Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. The Journal of Biological Chemistry. 274: 25945-52. PMID 10464339 DOI: 10.1074/Jbc.274.36.25945 |
0.583 |
|
| 1999 |
Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, Vassilev PM, Teplow DB, Selkoe DJ. Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons The Journal of Neuroscience. 19: 8876-8884. DOI: 10.1523/JNEUROSCI.19-20-08876.1999 |
0.479 |
|
| 1998 |
Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. The Journal of Biological Chemistry. 273: 32730-8. PMID 9830016 DOI: 10.1074/Jbc.273.49.32730 |
0.539 |
|
| 1997 |
Walsh DM, Lomakin A, Benedek GB, Condron MM, Teplow DB. Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate. The Journal of Biological Chemistry. 272: 22364-72. PMID 9268388 DOI: 10.1074/Jbc.272.35.22364 |
0.385 |
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