| Year | Citation | Score | |||
|---|---|---|---|---|---|
| 2021 | Chen X, Liu F, Rong D, Xu L, Tong X, Wang H. Decitabine Enhances Acute Myeloid Leukemia Cell Apoptosis through SH3BGRL Upregulation. Anti-Cancer Agents in Medicinal Chemistry. PMID 34963436 DOI: 10.2174/1871520622666211228110630 | 0.303 | |||
| 2013 | Mandal PK, Ren Z, Chen X, Kaluarachchi K, Liao WS, McMurray JS. Structure-Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3). International Journal of Peptide Research and Therapeutics. 19: 3-12. PMID 24707243 DOI: 10.1007/S10989-012-9313-0 | 0.477 | |||
| 2011 | Mandal PK, Gao F, Lu Z, Ren Z, Ramesh R, Birtwistle JS, Kaluarachchi KK, Chen X, Bast RC, Liao WS, McMurray JS. Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3. Journal of Medicinal Chemistry. 54: 3549-63. PMID 21486047 DOI: 10.1021/Jm2000882 | 0.489 | |||
| 2010 | Hazan-Halevy I, Harris D, Liu Z, Liu J, Li P, Chen X, Shanker S, Ferrajoli A, Keating MJ, Estrov Z. STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells. Blood. 115: 2852-63. PMID 20154216 DOI: 10.1182/blood-2009-10-230060 | 0.339 | |||
| 2010 | Huang S, Chang IS, Lin W, Ye W, Luo RZ, Lu Z, Lu Y, Zhang K, Liao WS, Tao T, Bast RC, Chen X, Yu Y. ARHI (DIRAS3), an imprinted tumour suppressor gene, binds to importins and blocks nuclear import of cargo proteins. Bioscience Reports. 30: 159-68. PMID 19435463 DOI: 10.1042/Bsr20090008 | 0.434 | |||
| 2010 | Mandal PK, Liao WS, Gao F, Robertson FM, Thudi NK, Ekmekcioglu S, Chattopadhyay C, Ren Z, Chen X, Lu Z, Bast RC, Ramesh R, McMurray JS. Abstract 2527: Potent, highly selective peptidomimetic prodrugs targeting the SH2 domain of Stat3 decrease vasculogenic mimicry, invasion, and anchorage independent growth of cancer cells Cancer Research. 70: 2527-2527. DOI: 10.1158/1538-7445.Am10-2527 | 0.388 | |||
| 2009 | Mandal PK, Ren Z, Chen X, Xiong C, McMurray JS. Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3. Journal of Medicinal Chemistry. 52: 6126-41. PMID 19728728 DOI: 10.1021/Jm901105K | 0.411 | |||
| 2009 | Lu M, Yang J, Ren Z, Sabui S, Espejo A, Bedford MT, Jacobson RH, Jeruzalmi D, McMurray JS, Chen X. Crystal structure of the three tandem FF domains of the transcription elongation regulator CA150. Journal of Molecular Biology. 393: 397-408. PMID 19660470 DOI: 10.1016/J.Jmb.2009.07.086 | 0.733 | |||
| 2009 | McMurray JS, Mandal PK, Liao WS, Ren Z, Chen X. Inhibition of Stat3 by cell-permeable peptidomimetic prodrugs targeted to its SH2 domain. Advances in Experimental Medicine and Biology. 611: 545-6. PMID 19400306 DOI: 10.1007/978-0-387-73657-0_239 | 0.439 | |||
| 2009 | McMurray JS, Ren Z, Mandal PK, Chen X. Model of intermolecular interactions between high affinity phosphopeptides and Stat3. Advances in Experimental Medicine and Biology. 611: 543-4. PMID 19400305 DOI: 10.1007/978-0-387-73657-0_238 | 0.317 | |||
| 2009 | Mandal PK, Limbrick D, Coleman DR, Dyer GA, Ren Z, Birtwistle JS, Xiong C, Chen X, Briggs JM, McMurray JS. Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription. 3: Evaluation and molecular modeling. Journal of Medicinal Chemistry. 52: 2429-42. PMID 19334714 DOI: 10.1021/Jm801491W | 0.433 | |||
| 2008 | Ren Z, Mao X, Mertens C, Krishnaraj R, Qin J, Mandal PK, Romanowski MJ, McMurray JS, Chen X. Crystal structure of unphosphorylated STAT3 core fragment. Biochemical and Biophysical Research Communications. 374: 1-5. PMID 18433722 DOI: 10.1016/J.Bbrc.2008.04.049 | 0.424 | |||
| 2008 | Huang S, Chang IS, Lin W, Luo R, Lu Z, Lu Y, Zhang K, Liao W, Tao T, Bast R, Chen X, Yu Y. ARHI (DIRAS 3), an Imprinted Tumor Suppressor Gene, Binds to Importins, and Blocks Nuclear Translocation of Stat3 Nature Precedings. DOI: 10.1038/Npre.2008.2392.1 | 0.321 | |||
| 2008 | Coleman IV DR, Kaluarachchi K, Ren Z, Chen X, McMurray JS. Solid phase synthesis of phosphopeptides incorporating 2,2- dimethyloxazolidine pseudoproline analogs: Evidence for trans Leu-Pro peptide bonds in Stat3 inhibitors International Journal of Peptide Research and Therapeutics. 14: 1-9. DOI: 10.1007/S10989-007-9099-7 | 0.305 | |||
| 2007 | Ginsberg M, Czeko E, Müller P, Ren Z, Chen X, Darnell JE. Amino acid residues required for physical and cooperative transcriptional interaction of STAT3 and AP-1 proteins c-Jun and c-Fos. Molecular and Cellular Biology. 27: 6300-8. PMID 17636030 DOI: 10.1128/Mcb.00613-07 | 0.598 | |||
| 2007 | Morales FC, Takahashi Y, Momin S, Adams H, Chen X, Georgescu MM. NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands. Molecular and Cellular Biology. 27: 2527-37. PMID 17242191 DOI: 10.1128/Mcb.01372-06 | 0.525 | |||
| 2006 | Mertens C, Zhong M, Krishnaraj R, Zou W, Chen X, Darnell JE. Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain. Genes & Development. 20: 3372-81. PMID 17182865 DOI: 10.1101/Gad.1485406 | 0.671 | |||
| 2005 | Coleman DR, Ren Z, Mandal PK, Cameron AG, Dyer GA, Muranjan S, Campbell M, Chen X, McMurray JS. Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor. Journal of Medicinal Chemistry. 48: 6661-70. PMID 16220982 DOI: 10.1021/Jm050513M | 0.454 | |||
| 2005 | Nishimoto A, Yu Y, Lu Z, Mao X, Ren Z, Watowich SS, Mills GB, Liao WS, Chen X, Bast RC, Luo RZ. A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells. Cancer Research. 65: 6701-10. PMID 16061651 DOI: 10.1158/0008-5472.Can-05-0130 | 0.359 | |||
| 2005 | Mao X, Ren Z, Parker GN, Sondermann H, Pastorello MA, Wang W, McMurray JS, Demeler B, Darnell JE, Chen X. Structural bases of unphosphorylated STAT1 association and receptor binding. Molecular Cell. 17: 761-71. PMID 15780933 DOI: 10.1016/J.Molcel.2005.02.021 | 0.729 | |||
| 2005 | Zhong M, Henriksen MA, Takeuchi K, Schaefer O, Liu B, ten Hoeve J, Ren Z, Mao X, Chen X, Shuai K, Darnell JE. Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle. Proceedings of the National Academy of Sciences of the United States of America. 102: 3966-71. PMID 15753310 DOI: 10.1073/Pnas.0501063102 | 0.751 | |||
| 2003 | Chen X, Bhandari R, Vinkemeier U, Van Den Akker F, Darnell JE, Kuriyan J. A reinterpretation of the dimerization interface of the N-terminal domains of STATs. Protein Science : a Publication of the Protein Society. 12: 361-5. PMID 12538899 DOI: 10.1110/Ps.0218903 | 0.712 | |||
| 1998 | Chen X, Vinkemeier U, Zhao Y, Jeruzalmi D, Darnell JE, Kuriyan J. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell. 93: 827-39. PMID 9630226 DOI: 10.1016/S0092-8674(00)81443-9 | 0.73 | |||
| 1998 | Chen X, Koshland DE. Probing the structure of the cytoplasmic domain of the aspartate receptor by targeted disulfide cross-linking Biochemistry. 37: 5335. PMID 9548766 DOI: 10.1021/bi9750293 | 0.56 | |||
| 1997 | Chen X, Koshland DE. Probing the structure of the cytoplasmic domain of the aspartate receptor by targeted disulfide cross-linking Biochemistry. 36: 11858-11864. PMID 9305978 DOI: 10.1021/bi970911u | 0.559 | |||
| 1995 | Chen X, Koshland DE. The N-terminal cytoplasmic tail of the aspartate receptor is not essential in signal transduction of bacterial chemotaxis Journal of Biological Chemistry. 270: 24038-24042. PMID 7592602 DOI: 10.1074/jbc.270.41.24038 | 0.465 | |||
| 1991 | Ito M, Guerriero V, Chen XM, Hartshorne DJ. Definition of the inhibitory domain of smooth muscle myosin light chain kinase by site-directed mutagenesis. Biochemistry. 30: 3498-503. PMID 2012809 DOI: 10.1021/Bi00228A021 | 0.632 | |||
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