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Edward P. Debold, Ph.D. - Publications

Affiliations: 
2002 Marquette University, Milwaukee, WI, United States 
Area:
Animal Physiology Biology
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45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Liu S, Marang C, Woodward M, Joumaa V, Leonard T, Scott B, Debold E, Herzog W, Walcott S. Modeling Thick Filament Activation Suggests a Molecular Basis for Force Depression. Biorxiv : the Preprint Server For Biology. PMID 37808737 DOI: 10.1101/2023.09.27.559764  0.376
2020 Woodward M, Ostrander E, Jeong SP, Liu X, Scott B, Unger M, Chen J, Venkataraman D, Debold EP. Positional Isomers of a Non-Nucleoside Substrate Differentially Affect Myosin Function. Biophysical Journal. PMID 32652059 DOI: 10.1016/J.Bpj.2020.06.024  0.408
2020 Arbore C, Pavone FS, Capitanio M, Debold EP. Timing and Load-dependence of the Powerstroke and Pi-release in Skeletal Muscle Myosin Biophysical Journal. 118: 122a. DOI: 10.1016/J.Bpj.2019.11.803  0.394
2019 Unger M, Debold EP. Acidosis decreases the Ca-sensitivity of thin filaments by preventing the first actomyosin interaction. American Journal of Physiology. Cell Physiology. PMID 31339771 DOI: 10.1152/Ajpcell.00196.2019  0.478
2019 Foster AD, Straight CR, Debold EP, Miller MS. Skeletal Muscle Fatigue: Mechanisms And Mitigation At The Cellular And Molecular Levels In Older Adults Medicine & Science in Sports & Exercise. 51: 615. DOI: 10.1249/01.Mss.0000562339.87393.19  0.366
2019 Woodward M, Debold EP. Mechanisms Through Which Agents Of Muscle Fatigue, Acidosis And Phosphate, Inhibit Muscle Myosin Function. Medicine & Science in Sports & Exercise. 51: 500. DOI: 10.1249/01.Mss.0000562004.14759.0D  0.435
2019 Scott B, Woodward M, Prum T, Moore JR, Debold EP. Tropomyosin-based Effects Of Acidosis On Thin-filament Regulation During Muscle Fatigue Medicine & Science in Sports & Exercise. 51: 318. DOI: 10.1249/01.Mss.0000561464.28722.C3  0.43
2019 Mohran S, Woodward M, Castillo R, Whithers M, Daggett V, Debold E, Regnier M. dATP Reduces the Depressive Effect of Acidosis on Cardiac and Slow Twitch Skeletal Muscle Biophysical Journal. 116: 261a. DOI: 10.1016/J.Bpj.2018.11.1422  0.395
2018 Jarvis K, Woodward M, Debold EP, Walcott S. Acidosis affects muscle contraction by slowing the rates myosin attaches to and detaches from actin. Journal of Muscle Research and Cell Motility. PMID 30382520 DOI: 10.1007/S10974-018-9499-7  0.524
2018 Woodward M, Debold EP. Acidosis and Phosphate Directly Reduce Myosin's Force-Generating Capacity Through Distinct Molecular Mechanisms. Frontiers in Physiology. 9: 862. PMID 30042692 DOI: 10.3389/Fphys.2018.00862  0.501
2018 Jarvis K, Debold EP, Walcott S, Woodward M. A Minimal Model for the Effects of pH and Phosphate on Muscle Provides a Molecular Basis for Cellular Measurements Biophysical Journal. 114: 211a. DOI: 10.1016/J.Bpj.2017.11.1183  0.394
2017 Longyear T, Walcott S, Debold EP. The molecular basis of thin filament activation: from single molecule to muscle. Scientific Reports. 7: 1822. PMID 28500282 DOI: 10.1038/S41598-017-01604-8  0.422
2017 Longyear T, Walcott S, Debold EP. Effect of Calcium on Myosin Binding to a Regulated Thin Filament from Single Molecule to Ensemble Biophysical Journal. 112: 116a. DOI: 10.1016/J.Bpj.2016.11.652  0.456
2016 Debold EP. Decreased Myofilament Calcium Sensitivity Plays a Significant Role in Muscle Fatigue. Exercise and Sport Sciences Reviews. 44: 144-9. PMID 27526194 DOI: 10.1249/Jes.0000000000000089  0.44
2016 Debold EP, Fitts RH, Sundberg CW, Nosek TM. Muscle Fatigue from the Perspective of a Single Cross-bridge. Medicine and Science in Sports and Exercise. PMID 27434086 DOI: 10.1249/Mss.0000000000001047  0.654
2016 Debold E, Unger M, Longyear T. The Acidosis-Induced Slowing of Regulated Thin Filament Velocity in a Motility Assay Disappears at Low ATP Biophysical Journal. 110: 303a. DOI: 10.1016/J.Bpj.2015.11.1628  0.438
2016 Longyear T, Unger M, Xin L, Walcott S, Debold EP. Using Single Myosin and Small Myosin Ensembles to Examine Thin Filament Activation in a Laser Trap Assay Biophysical Journal. 110: 302a. DOI: 10.1016/J.Bpj.2015.11.1626  0.411
2015 Debold EP. Potential molecular mechanisms underlying muscle fatigue mediated by reactive oxygen and nitrogen species. Frontiers in Physiology. 6: 239. PMID 26388779 DOI: 10.3389/Fphys.2015.00239  0.43
2015 Debold EP. Biological machines: Molecular motor teamwork. Nature Nanotechnology. 10: 656-7. PMID 26243000 DOI: 10.1038/Nnano.2015.175  0.366
2015 Woodward M, Previs MJ, Mader TJ, Debold EP. Modifications of myofilament protein phosphorylation and function in response to cardiac arrest induced in a swine model. Frontiers in Physiology. 6: 199. PMID 26236240 DOI: 10.3389/Fphys.2015.00199  0.33
2015 Longyear TJ, Walcott S, Debold EP. Observing the pCa-Force Relationship with a 3-Bead Laser Trap Assay Biophysical Journal. 108: 422a. DOI: 10.1016/J.Bpj.2014.11.2310  0.42
2014 Nelson CR, Debold EP, Fitts RH. Phosphate and acidosis act synergistically to depress peak power in rat muscle fibers. American Journal of Physiology. Cell Physiology. 307: C939-50. PMID 25186012 DOI: 10.1152/Ajpcell.00206.2014  0.688
2014 Swenson AM, Trivedi DV, Rauscher AA, Wang Y, Takagi Y, Palmer BM, Málnási-Csizmadia A, Debold EP, Yengo CM. Magnesium modulates actin binding and ADP release in myosin motors. The Journal of Biological Chemistry. 289: 23977-91. PMID 25006251 DOI: 10.1074/Jbc.M114.562231  0.439
2014 Longyear TJ, Turner MA, Davis JP, Lopez J, Biesiadecki B, Debold EP. Ca++-sensitizing mutations in troponin, P(i), and 2-deoxyATP alter the depressive effect of acidosis on regulated thin-filament velocity. Journal of Applied Physiology (Bethesda, Md. : 1985). 116: 1165-74. PMID 24651988 DOI: 10.1152/Japplphysiol.01161.2013  0.431
2014 Longyear TJ, Turner MA, Biesiadecki BJ, Lopez J, Davis JP, Debold EP. Attentuating the Depressive Effect of Acidosis with Mutations in Troponin and with 2-Deoxy-Atp Biophysical Journal. 106: 724a. DOI: 10.1016/J.Bpj.2013.11.3999  0.441
2013 Debold EP, Walcott S, Woodward M, Turner MA. Direct observation of phosphate inhibiting the force-generating capacity of a miniensemble of Myosin molecules. Biophysical Journal. 105: 2374-84. PMID 24268149 DOI: 10.1016/J.Bpj.2013.09.046  0.444
2013 Kobayashi M, Debold EP, Turner MA, Kobayashi T. Cardiac muscle activation blunted by a mutation to the regulatory component, troponin T. The Journal of Biological Chemistry. 288: 26335-49. PMID 23897817 DOI: 10.1074/Jbc.M113.494096  0.379
2013 Longyear TJ, Turner MA, Lopez J, Davis JP, Debold EP. Phosphate Enhances Regulated Thin Filament Velocity at Acidic pH in the Motility Assay Biophysical Journal. 104: 450a-451a. DOI: 10.1016/J.Bpj.2012.11.2496  0.426
2013 Yar S, Chowdhury SA, Turner M, Rajan S, Wolska BM, Gaponenko V, Debold EP, Kobayashi T, Wieczorek DF, Solaro RJ. Altered Flexibility affects Regulatory Functions of Cardiac α-Tropomyosin (α-Tm) in a Novel Transgenic Mouse Model Expressing α-Tm-D137L Biophysical Journal. 104: 448a. DOI: 10.1016/J.Bpj.2012.11.2485  0.346
2013 Debold EP, Woodward M, Turner MA. The Effect of Phosphate on the Force Generating Capacity of a Mini-Ensemble of Myosin Measured in a Laser Trap Assay Biophysical Journal. 104: 306a. DOI: 10.1016/J.Bpj.2012.11.1703  0.395
2012 Debold EP, Longyear TJ, Turner MA. The effects of phosphate and acidosis on regulated thin-filament velocity in an in vitro motility assay. Journal of Applied Physiology (Bethesda, Md. : 1985). 113: 1413-22. PMID 23019317 DOI: 10.1152/Japplphysiol.00775.2012  0.45
2012 Walcott S, Warshaw DM, Debold EP. Mechanical coupling between myosin molecules causes differences between ensemble and single-molecule measurements. Biophysical Journal. 103: 501-10. PMID 22947866 DOI: 10.1016/J.Bpj.2012.06.031  0.406
2012 Debold EP. Recent insights into muscle fatigue at the cross-bridge level. Frontiers in Physiology. 3: 151. PMID 22675303 DOI: 10.3389/Fphys.2012.00151  0.517
2012 Debold EP. Recent insights into the molecular basis of muscular fatigue. Medicine and Science in Sports and Exercise. 44: 1440-52. PMID 22330018 DOI: 10.1249/Mss.0B013E31824Cfd26  0.44
2012 Debold EP, Longyear T, Turner M, Woodward M. The Effects of Phosphate and Hydrogen Ions on the Velocity-pCa Relationship in a Motility Assay Biophysical Journal. 102: 154a. DOI: 10.1016/J.Bpj.2011.11.840  0.429
2012 Walcott S, Debold EP. Myosin-Induced Detachment Causes Differences Between Ensemble and Single Molecule Myosin Kinetics Biophysical Journal. 102: 17a-18a. DOI: 10.1016/J.Bpj.2011.11.119  0.456
2011 Debold EP, Turner MA, Stout JC, Walcott S. Phosphate enhances myosin-powered actin filament velocity under acidic conditions in a motility assay. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 300: R1401-8. PMID 21346239 DOI: 10.1152/Ajpregu.00772.2010  0.426
2011 Debold EP, Turner M, Stout JC, Walcott SC. Phosphate Enhances Actin Filament Velocity at Low pH in an in vitro Motility Assay Biophysical Journal. 100: 128a-129a. DOI: 10.1016/J.Bpj.2010.12.907  0.372
2010 Debold EP, Saber W, Cheema Y, Bookwalter CS, Trybus KM, Warshaw DM, Vanburen P. Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitro. Journal of Molecular and Cellular Cardiology. 48: 286-92. PMID 19799913 DOI: 10.1016/J.Yjmcc.2009.09.014  0.403
2008 Debold EP, Beck SE, Warshaw DM. Effect of low pH on single skeletal muscle myosin mechanics and kinetics American Journal of Physiology - Cell Physiology. 295. PMID 18480297 DOI: 10.1152/Ajpcell.00172.2008  0.409
2007 Debold EP, Schmitt JP, Patlak JB, Beck SE, Moore JR, Seidman JG, Seidman C, Warshaw DM. Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay. American Journal of Physiology. Heart and Circulatory Physiology. 293: H284-91. PMID 17351073 DOI: 10.1152/Ajpheart.00128.2007  0.346
2006 Schmitt JP, Debold EP, Ahmad F, Armstrong A, Frederico A, Conner DA, Mende U, Lohse MJ, Warshaw D, Seidman CE, Seidman JG. Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function. Proceedings of the National Academy of Sciences of the United States of America. 103: 14525-30. PMID 16983074 DOI: 10.1073/Pnas.0606383103  0.35
2005 Debold EP, Romatowski J, Fitts RH. The depressive effect of Pi on the force-pCa relationship in skinned single muscle fibers is temperature dependent. American Journal of Physiology. Cell Physiology. 290: C1041-50. PMID 16282195 DOI: 10.1152/Ajpcell.00342.2005  0.624
2005 Debold EP, Patlak JB, Warshaw DM. Slip sliding away: load-dependence of velocity generated by skeletal muscle myosin molecules in the laser trap. Biophysical Journal. 89: L34-6. PMID 16169988 DOI: 10.1529/Biophysj.105.072967  0.44
2004 Debold EP, Dave H, Fitts RH. Fiber type and temperature dependence of inorganic phosphate: implications for fatigue. American Journal of Physiology. Cell Physiology. 287: C673-81. PMID 15128502 DOI: 10.1152/Ajpcell.00044.2004  0.579
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