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Richard T Eastman - Publications

Affiliations: 
National Insitutes of Health, Bethesda, MD, United States 
Area:
Microbiology, Infectious Diseases, Malaria
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46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Calit J, Araújo JE, Deng B, Miura K, Gaitán XA, Araújo MDS, Medeiros JF, Long CA, Simeonov A, Eastman RT, Bargieri DY. Novel Transmission-Blocking Antimalarials Identified by High-Throughput Screening of Plasmodium berghei Ookluc. Antimicrobial Agents and Chemotherapy. e0146522. PMID 36856421 DOI: 10.1128/aac.01465-22  0.383
2023 Singh BK, Zhang C, Wu J, Peng YC, He X, Tumas KC, Sá JM, Lane KD, Eastman RT, Narum DL, Wellems TE, Su XZ. A Plasmodium falciparum RING Finger E3 Ubiquitin Ligase Modifies the Roles of PfMDR1 and PfCRT in Parasite Drug Responses. Antimicrobial Agents and Chemotherapy. e0082122. PMID 36625569 DOI: 10.1128/aac.00821-22  0.716
2021 Le Manach C, Dam J, Woodland JG, Kaur G, Khonde LP, Brunschwig C, Njoroge M, Wicht KJ, Horatscheck A, Paquet T, Boyle GA, Gibhard L, Taylor D, Lawrence N, Yeo T, ... Eastman RT, et al. Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite and Optimization Efforts. Journal of Medicinal Chemistry. PMID 33573376 DOI: 10.1021/acs.jmedchem.1c00034  0.316
2021 Dorjsuren D, Eastman RT, Wicht KJ, Jansen D, Talley DC, Sigmon BA, Zakharov AV, Roncal N, Girvin AT, Antonova-Koch Y, Will PM, Shah P, Sun H, Klumpp-Thomas C, Mok S, et al. Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites. Scientific Reports. 11: 2121. PMID 33483532 DOI: 10.1038/s41598-021-81486-z  0.363
2020 Chen CZ, Shinn P, Itkin Z, Eastman RT, Bostwick R, Rasmussen L, Huang R, Shen M, Hu X, Wilson KM, Brooks BM, Guo H, Zhao T, Klump-Thomas C, Simeonov A, et al. Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2. Frontiers in Pharmacology. 11: 592737. PMID 33708112 DOI: 10.3389/fphar.2020.592737  0.303
2020 Ansbro MR, Itkin Z, Chen L, Zahoranszky-Kohalmi G, Amaratunga C, Miotto O, Peryea T, Hobbs CV, Suon S, Sá JM, Dondorp AM, van der Pluijm RW, Wellems TE, Simeonov A, Eastman RT. Modulation of Triple Artemisinin-Based Combination Therapy Pharmacodynamics by Genotype. Acs Pharmacology & Translational Science. 3: 1144-1157. PMID 33344893 DOI: 10.1021/acsptsci.0c00110  0.624
2020 Chen CZ, Shinn P, Itkin Z, Eastman RT, Bostwick R, Rasmussen L, Huang R, Shen M, Hu X, Wilson KM, Brooks B, Guo H, Zhao T, Klump-Thomas C, Simeonov A, et al. Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2. Biorxiv : the Preprint Server For Biology. PMID 32839771 DOI: 10.1101/2020.08.18.255877  0.3
2020 Bobrowski T, Chen L, Eastman RT, Itkin Z, Shinn P, Chen C, Guo H, Zheng W, Michael S, Simeonov A, Hall MD, Zakharov AV, Muratov EN. Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro. Biorxiv : the Preprint Server For Biology. PMID 32637956 DOI: 10.1101/2020.06.29.178889  0.309
2019 Sá JM, Kaslow SR, Moraes Barros RR, Brazeau NF, Parobek CM, Tao D, Salzman RE, Gibson TJ, Velmurugan S, Krause MA, Melendez-Muniz V, Kite WA, Han PK, Eastman RT, Kim A, et al. Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross. Nature Communications. 10: 4300. PMID 31541097 DOI: 10.1038/S41467-019-12256-9  0.663
2018 Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Eastman RT, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/Acscentsci.8B00747  0.318
2018 Sá JM, Kaslow SR, Krause MA, Melendez-Muniz VA, Salzman RE, Kite WA, Zhang M, Moraes Barros RR, Mu J, Han PK, Mershon JP, Figan CE, Caleon RL, Rahman RS, Gibson TJ, ... Eastman RT, et al. Artemisinin resistance phenotypes and K13 inheritance in a cross and model. Proceedings of the National Academy of Sciences of the United States of America. PMID 30455312 DOI: 10.1073/Pnas.1813386115  0.676
2018 Breglio KF, Amato R, Eastman R, Lim P, Sa JM, Guha R, Ganesan S, Dorward DW, Klumpp-Thomas C, McKnight C, Fairhurst RM, Roberts D, Thomas C, Simon AK. A single nucleotide polymorphism in the Plasmodium falciparum atg18 gene associates with artemisinin resistance and confers enhanced parasite survival under nutrient deprivation. Malaria Journal. 17: 391. PMID 30367653 DOI: 10.1186/S12936-018-2532-X  0.4
2018 Mason DJ, Eastman RT, Lewis RPI, Stott IP, Guha R, Bender A. Using Machine Learning to Predict Synergistic Antimalarial Compound Combinations With Novel Structures. Frontiers in Pharmacology. 9: 1096. PMID 30333748 DOI: 10.3389/Fphar.2018.01096  0.4
2018 Calit J, Dobrescu I, Gaitán XA, Borges MH, Ramos MS, Eastman RT, Bargieri DY. Screening the Pathogen Box against sexual stages using a new nanoluciferase based transgenic line of identifies transmission-blocking compounds. Antimicrobial Agents and Chemotherapy. PMID 30181368 DOI: 10.1128/Aac.01053-18  0.397
2018 Kasule J, Gabriel EE, Anok A, Neal J, Eastman RT, Penzak S, Newell K, Serwadda D, Duffy PE, Reynolds SJ, Hobbs CV. Sulfamethoxazole Levels in HIV-Exposed Uninfected Ugandan Children. The American Journal of Tropical Medicine and Hygiene. PMID 29692311 DOI: 10.4269/Ajtmh.17-0933  0.306
2018 KalantarMotamedi Y, Eastman RT, Guha R, Bender A. A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria. Malaria Journal. 17: 160. PMID 29642892 DOI: 10.1186/S12936-018-2294-5  0.424
2017 Lacerda-Queiroz N, Riteau N, Eastman RT, Bock KW, Orandle MS, Moore IN, Sher A, Long CA, Jankovic D, Su XZ. Mechanism of splenic cell death and host mortality in a Plasmodium yoelii malaria model. Scientific Reports. 7: 10438. PMID 28874800 DOI: 10.1038/S41598-017-10776-2  0.588
2017 Nair SC, Xu R, Pattaradilokrat S, Wu J, Qi Y, Zilversmit M, Ganesan S, Nagarajan V, Eastman RT, Orandle MS, Tan JC, Myers TG, Liu S, Long CA, Li J, et al. A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence. Nature Communications. 8: 223. PMID 28790316 DOI: 10.1038/S41467-017-00267-3  0.627
2016 Eastman RT, Khine P, Huang R, Thomas CJ, Su XZ. PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers. Scientific Reports. 6: 25379. PMID 27147113 DOI: 10.1038/Srep25379  0.647
2015 Cheng KC, Cao S, Raveh A, MacArthur R, Dranchak P, Chlipala G, Okoneski MT, Guha R, Eastman RT, Yuan J, Schultz PJ, Su XZ, Tamayo-Castillo G, Matainaho T, Clardy J, et al. Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts. Journal of Natural Products. PMID 26465675 DOI: 10.1021/Acs.Jnatprod.5B00489  0.545
2015 Mott BT, Eastman RT, Guha R, Sherlach KS, Siriwardana A, Shinn P, McKnight C, Michael S, Lacerda-Queiroz N, Patel PR, Khine P, Sun H, Kasbekar M, Aghdam N, Fontaine SD, et al. High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations. Scientific Reports. 5: 13891. PMID 26403635 DOI: 10.1038/Srep13891  0.637
2015 Qi Y, Zhu F, Eastman RT, Fu Y, Zilversmit M, Pattaradilokrat S, Hong L, Liu S, McCutchan TF, Pan W, Xu W, Li J, Huang F, Su XZ. Regulation of Plasmodium yoelii oocyst development by strain- and stage-specific small-subunit rRNA. Mbio. 6: e00117. PMID 25759501 DOI: 10.1128/Mbio.00117-15  0.586
2014 Lisewski AM, Quiros JP, Ng CL, Adikesavan AK, Miura K, Putluri N, Eastman RT, Scanfeld D, Regenbogen SJ, Altenhofen L, Llinás M, Sreekumar A, Long C, Fidock DA, Lichtarge O. Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate. Cell. 158: 916-28. PMID 25126794 DOI: 10.1016/J.Cell.2014.07.011  0.336
2014 Ojo KK, Eastman RT, Vidadala R, Zhang Z, Rivas KL, Choi R, Lutz JD, Reid MC, Fox AM, Hulverson MA, Kennedy M, Isoherranen N, Kim LM, Comess KM, Kempf DJ, et al. A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation. The Journal of Infectious Diseases. 209: 275-84. PMID 24123773 DOI: 10.1093/Infdis/Jit522  0.72
2013 Lemieux JE, Kyes SA, Otto TD, Feller AI, Eastman RT, Pinches RA, Berriman M, Su XZ, Newbold CI. Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variation. Molecular Microbiology. 90: 519-37. PMID 23980881 DOI: 10.1111/Mmi.12381  0.549
2013 Lim P, Dek D, Try V, Eastman RT, Chy S, Sreng S, Suon S, Mao S, Sopha C, Sam B, Ashley EA, Miotto O, Dondorp AM, White NJ, Su XZ, et al. Ex vivo susceptibility of Plasmodium falciparum to antimalarial drugs in western, northern, and eastern Cambodia, 2011-2012: association with molecular markers. Antimicrobial Agents and Chemotherapy. 57: 5277-83. PMID 23939897 DOI: 10.1128/Aac.00687-13  0.639
2013 Eastman RT, Pattaradilokrat S, Raj DK, Dixit S, Deng B, Miura K, Yuan J, Tanaka TQ, Johnson RL, Jiang H, Huang R, Williamson KC, Lambert LE, Long C, Austin CP, et al. A class of tricyclic compounds blocking malaria parasite oocyst development and transmission. Antimicrobial Agents and Chemotherapy. 57: 425-35. PMID 23129054 DOI: 10.1128/Aac.00920-12  0.69
2011 Adjalley SH, Johnston GL, Li T, Eastman RT, Ekland EH, Eappen AG, Richman A, Sim BK, Lee MC, Hoffman SL, Fidock DA. Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue. Proceedings of the National Academy of Sciences of the United States of America. 108: E1214-23. PMID 22042867 DOI: 10.1073/Pnas.1112037108  0.441
2011 Eastman RT, Dharia NV, Winzeler EA, Fidock DA. Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites. Antimicrobial Agents and Chemotherapy. 55: 3908-16. PMID 21576453 DOI: 10.1128/Aac.01793-10  0.428
2011 Petersen I, Eastman R, Lanzer M. Drug-resistant malaria: molecular mechanisms and implications for public health. Febs Letters. 585: 1551-62. PMID 21530510 DOI: 10.1016/J.Febslet.2011.04.042  0.471
2009 Eastman RT, Fidock DA. Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. Nature Reviews. Microbiology. 7: 864-74. PMID 19881520 DOI: 10.1038/Nrmicro2239  0.471
2009 Dharia NV, Sidhu AB, Cassera MB, Westenberger SJ, Bopp SE, Eastman RT, Plouffe D, Batalov S, Park DJ, Volkman SK, Wirth DF, Zhou Y, Fidock DA, Winzeler EA. Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biology. 10: R21. PMID 19216790 DOI: 10.1186/Gb-2009-10-2-R21  0.469
2008 Fidock DA, Eastman RT, Ward SA, Meshnick SR. Recent highlights in antimalarial drug resistance and chemotherapy research. Trends in Parasitology. 24: 537-44. PMID 18938106 DOI: 10.1016/J.Pt.2008.09.005  0.396
2007 Gillespie JR, Yokoyama K, Lu K, Eastman RT, Bollinger JG, Van Voorhis WC, Gelb MH, Buckner FS. C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins. Molecular and Biochemical Parasitology. 153: 115-24. PMID 17397944 DOI: 10.1016/J.Molbiopara.2007.02.009  0.518
2007 Eastman RT, White J, Hucke O, Yokoyama K, Verlinde CL, Hast MA, Beese LS, Gelb MH, Rathod PK, Van Voorhis WC. Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Molecular and Biochemical Parasitology. 152: 66-71. PMID 17208314 DOI: 10.1016/J.Molbiopara.2006.11.012  0.602
2006 Eastman RT, Buckner FS, Yokoyama K, Gelb MH, Van Voorhis WC. Fighting parasitic disease by blocking protein farnesylation Journal of Lipid Research. 47: 233-240. PMID 16339110 DOI: 10.1194/Jlr.R500016-Jlr200  0.586
2005 Eastman RT, Barrett LK, Dupuis K, Buckner FS, Van Voorhis WC. Leishmania inactivation in human pheresis platelets by a psoralen (amotosalen HCl) and long-wavelength ultraviolet irradiation Transfusion. 45: 1459-1463. PMID 16131378 DOI: 10.1111/J.1537-2995.2005.00552.X  0.513
2005 Buckner FS, Eastman RT, Yokoyama K, Gelb MH, Van Voorhis WC. Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis Current Opinion in Investigational Drugs. 6: 791-797. PMID 16121685  0.595
2005 Eastman RT, White J, Hucke O, Bauer K, Yokoyama K, Nallan L, Chakrabarti D, Verlinde CL, Gelb MH, Rathod PK, Van Voorhis WC. Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum. The Journal of Biological Chemistry. 280: 13554-9. PMID 15661734 DOI: 10.1074/Jbc.M413556200  0.611
2005 Vigna KL, Hucke O, Eastman R, Verlinde CL, Van Voorhis WC. 314 MOLECULAR MODELING OF FARNESYLTRANSFERASE INHIBITORS FOR MALARIA THERAPEUTICS Journal of Investigative Medicine. 53: S133.3-S133. DOI: 10.2310/6650.2005.00005.313  0.647
2004 Ohkanda J, Buckner FS, Lockman JW, Yokoyama K, Carrico D, Eastman R, de Luca-Fradley K, Davies W, Croft SL, Van Voorhis WC, Gelb MH, Sebti SM, Hamilton AD. Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents. Journal of Medicinal Chemistry. 47: 432-45. PMID 14711313 DOI: 10.1021/Jm030236O  0.557
2003 Buckner FS, Joubert BM, Boyle SM, Eastman RT, Verlinde CL, Matsuda SP. Cloning and analysis of Trypanosoma cruzi lanosterol 14alpha-demethylase. Molecular and Biochemical Parasitology. 132: 75-81. PMID 14599667 DOI: 10.1016/J.Molbiopara.2003.07.004  0.399
2003 Hinshaw JC, Suh DY, Garnier P, Buckner FS, Eastman RT, Matsuda SP, Joubert BM, Coppens I, Joiner KA, Merali S, Nash TE, Prestwich GD. Oxidosqualene cyclase inhibitors as antimicrobial agents. Journal of Medicinal Chemistry. 46: 4240-3. PMID 13678402 DOI: 10.1021/Jm034126T  0.359
2003 Gelb MH, Van Voorhis WC, Buckner FS, Yokoyama K, Eastman R, Carpenter EP, Panethymitaki C, Brown KA, Smith DF. Protein farnesyl and N-myristoyl transferases: Piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics Molecular and Biochemical Parasitology. 126: 155-163. PMID 12615314 DOI: 10.1016/S0166-6851(02)00282-7  0.609
2003 Van Voorhis WC, Barrett LK, Eastman RT, Alfonso R, Dupuis K. Trypanosoma cruzi inactivation in human platelet concentrates and plasma by a psoralen (Amotosalen HCl) and long-wavelength UV Antimicrobial Agents and Chemotherapy. 47: 475-479. PMID 12543646 DOI: 10.1128/Aac.47.2.475-479.2003  0.476
2002 Buckner FS, Eastman RT, Nepomuceno-Silva JL, Speelmon EC, Myler PJ, Van Voorhis WC, Yokoyama K. Cloning, heterologous expression, and substrate specificities of protein farnesyltransferases from Trypanosoma cruzi and Leishmania major. Molecular and Biochemical Parasitology. 122: 181-8. PMID 12106872 DOI: 10.1016/S0166-6851(02)00099-3  0.574
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