| Year |
Citation |
Score |
| 2024 |
Phelps GA, Cheramie MN, Fernando DM, Selchow P, Meyer CJ, Waidyarachchi SL, Dharuman S, Liu J, Meuli M, Molin MD, Killam BY, Murphy PA, Reeve SM, Wilt LA, Anderson SM, ... ... Lee RB, ... ... Lee RE, et al. Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in abscessus. Proceedings of the National Academy of Sciences of the United States of America. 121: e2314101120. PMID 38165935 DOI: 10.1073/pnas.2314101120 |
0.736 |
|
| 2023 |
Buchholz CR, Sneddon MS, McPherson JE, Das S, Gee CT, Grillo MJ, Chai SC, Lee RE, Chen T, Harki DA, Shelat AA, Pomerantz WCK. Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors. Acs Medicinal Chemistry Letters. 14: 1441-1447. PMID 37849548 DOI: 10.1021/acsmedchemlett.3c00343 |
0.712 |
|
| 2023 |
Scott DC, King MT, Baek K, Gee CT, Kalathur R, Li J, Purser N, Nourse A, Chai SC, Vaithiyalingam S, Chen T, Lee RE, Elledge SJ, Kleiger G, Schulman BA. E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity. Molecular Cell. PMID 36805027 DOI: 10.1016/j.molcel.2023.01.019 |
0.701 |
|
| 2022 |
Leshchiner D, Rosconi F, Sundaresh B, Rudmann E, Ramirez LMN, Nishimoto AT, Wood SJ, Jana B, Buján N, Li K, Gao J, Frank M, Reeve SM, Lee RE, Rock CO, et al. A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance. Nature Communications. 13: 3165. PMID 35672367 DOI: 10.1038/s41467-022-30967-4 |
0.729 |
|
| 2022 |
Dharuman S, Wallace MJ, Reeve SM, Bulitta JB, Lee RE. Synthesis and Structure-Activity Relationship of Thioacetamide-Triazoles against . Molecules (Basel, Switzerland). 27. PMID 35268619 DOI: 10.3390/molecules27051518 |
0.735 |
|
| 2022 |
Cui H, Divakaran A, Hoell ZJ, Ellingson MO, Scholtz CR, Zahid H, Johnson JA, Griffith EC, Gee CT, Lee AL, Khanal S, Shi K, Aihara H, Shah VH, Lee RE, et al. A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes. Journal of Medicinal Chemistry. PMID 35007061 DOI: 10.1021/acs.jmedchem.1c01779 |
0.714 |
|
| 2021 |
Fernando DM, Gee CT, Griffith EC, Meyer CJ, Wilt LA, Tangallapally R, Wallace MJ, Miller DJ, Lee RE. Biophysical analysis of the Mycobacteria tuberculosis peptide binding protein DppA reveals a stringent peptide binding pocket. Tuberculosis (Edinburgh, Scotland). 132: 102157. PMID 34894561 DOI: 10.1016/j.tube.2021.102157 |
0.713 |
|
| 2021 |
Sharma S, Rao R, Reeve SM, Phelps GA, Bharatham N, Katagihallimath N, Ramachandran V, Raveendran S, Sarma M, Nath A, Thomas T, Manickam D, Nagaraj S, Balasubramanian V, Lee RE, et al. Azaindole Based Potentiator of Antibiotics against Gram-Negative Bacteria. Acs Infectious Diseases. PMID 34699190 DOI: 10.1021/acsinfecdis.1c00171 |
0.73 |
|
| 2021 |
Lang Y, Shah NR, Tao X, Reeve SM, Zhou J, Moya B, Sayed ARM, Dharuman S, Oyer JL, Copik AJ, Fleischer BA, Shin E, Werkman C, Basso KB, Deveson Lucas D, ... ... Lee RE, et al. Combating multidrug-resistant bacteria by integrating a novel target site penetration and receptor binding assay platform into translational modeling. Clinical Pharmacology and Therapeutics. PMID 33576025 DOI: 10.1002/cpt.2205 |
0.739 |
|
| 2021 |
Dharuman S, Wilt LA, Liu J, Reeve SM, Thompson CW, Elmore JM, Shcherbakov D, Lee RB, Böttger EC, Lee RE. Synthesis, antibacterial action, and ribosome inhibition of deoxyspectinomycins. The Journal of Antibiotics. PMID 33504919 DOI: 10.1038/s41429-021-00408-3 |
0.721 |
|
| 2021 |
Mugengana AK, Vita NA, Brown Gandt A, Moran K, Agyapong G, Sharma LK, Griffith EC, Liu J, Yang L, Gavrish E, Hevener KE, LaFleur MD, Lee RE. The Discovery and Development of Thienopyrimidines as Inhibitors of That Act through Inhibition of the Respiratory Complex I. Acs Infectious Diseases. PMID 33471519 DOI: 10.1021/acsinfecdis.0c00300 |
0.339 |
|
| 2020 |
Yang SW, Huang X, Lin W, Min J, Miller DJ, Mayasundari A, Rodrigues P, Griffith EC, Gee CT, Li L, Li W, Lee RE, Rankovic Z, Chen T, Potts PR. Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases. Nature Communications. 11: 4931. PMID 33004795 DOI: 10.1038/s41467-020-18708-x |
0.713 |
|
| 2020 |
Kim TH, Tao X, Moya B, Jiao Y, Basso KB, Zhou J, Lang Y, Sutaria DS, Zavascki AP, Barth AL, Reeve SM, Schweizer HP, Deveson Lucas D, Boyce JD, Bonomo RA, ... Lee RE, et al. Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant and . Mbio. 11. PMID 32047131 DOI: 10.1128/Mbio.03189-19 |
0.709 |
|
| 2019 |
Wallace MJ, Dharuman S, Fernando D, Reeve SM, Gee C, Yao J, Griffith E, Phelps G, Wright WC, Elmore J, Lee RB, Chen T, Lee RE. Discovery and characterization of the antimetabolite action of thioacetamide-linked 1,2,3-triazoles as disruptors of cysteine biosynthesis in Gram-negative bacteria. Acs Infectious Diseases. PMID 31887254 DOI: 10.1021/Acsinfecdis.9B00406 |
0.733 |
|
| 2019 |
Grzegorzewicz AE, Gee C, Das S, Liu J, Belardinelli JM, Jones V, McNeil MR, Lee RE, Jackson MC. Mechanisms of resistance associated with the inhibition of the dehydration step of FAS-II in Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 31775512 DOI: 10.1021/Acsinfecdis.9B00162 |
0.724 |
|
| 2019 |
Scarff JM, Waidyarachchi SL, Meyer CJ, Lane DJ, Chai W, Lemmon MM, Liu J, Butler MM, Bowlin TL, Lee RE, Panchal RG. Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens. The Journal of Antibiotics. PMID 31164713 DOI: 10.1038/s41429-019-0194-8 |
0.304 |
|
| 2018 |
Griffith EC, Wallace MJ, Wu Y, Kumar G, Gajewski S, Jackson P, Phelps GA, Zheng Z, Rock CO, Lee RE, White SW. The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Dihydropteroate Synthase. Frontiers in Microbiology. 9: 1369. PMID 30065703 DOI: 10.3389/fmicb.2018.01369 |
0.314 |
|
| 2018 |
Brown Gandt A, Griffith EC, Lister IM, Billings LL, Han A, Tangallapally R, Zhao Y, Singh AP, Lee RE, LaFleur MD. In vivo and in vitro effects of a ClpP activating antibiotic against vancomycin resistant enterococci. Antimicrobial Agents and Chemotherapy. PMID 29784838 DOI: 10.1128/AAC.00424-18 |
0.307 |
|
| 2018 |
Griffith EC, Wallace MJ, Wu Y, Kumar G, Gajewski S, Jackson P, Phelps GA, Zheng Z, Rock CO, Lee RE, White SW. The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations inStaphylococcus aureusDihydropteroate Synthase. Frontiers in Microbiology. 9: 1369-1369. DOI: 10.2210/Pdb6Clu/Pdb |
0.315 |
|
| 2017 |
Liu J, Bruhn DF, Lee RB, Zheng Z, Janusic T, Scherbakov D, Scherman MS, Boshoff HI, Das S, Rakesh, Waidyarachchi SL, Brewer TA, Gracia B, Yang L, Bollinger J, ... ... Lee RE, et al. Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions. Acs Infectious Diseases. 3: 72-88. PMID 28081607 DOI: 10.1021/Acsinfecdis.6B00158 |
0.317 |
|
| 2016 |
Cassilly CD, Maddox MM, Cherian PT, Bowling JJ, Hamann MT, Lee RE, Reynolds TB. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. Plos One. 11: e0154932. PMID 27183222 DOI: 10.1371/Journal.Pone.0154932 |
0.308 |
|
| 2015 |
Bruhn DF, Waidyarachchi SL, Madhura DB, Shcherbakov D, Zheng Z, Liu J, Abdelrahman YM, Singh AP, Duscha S, Rathi C, Lee RB, Belland RJ, Meibohm B, Rosch JW, Böttger EC, ... Lee RE, et al. Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections. Science Translational Medicine. 7: 288ra75. PMID 25995221 DOI: 10.1126/Scitranslmed.3010572 |
0.32 |
|
| 2014 |
Hammoudeh DI, Daté M, Yun MK, Zhang W, Boyd VA, Viacava Follis A, Griffith E, Lee RE, Bashford D, White SW. Identification and characterization of an allosteric inhibitory site on dihydropteroate synthase. Acs Chemical Biology. 9: 1294-302. PMID 24650357 DOI: 10.1021/Cb500038G |
0.322 |
|
| 2014 |
Yun MK, Hoagland D, Kumar G, Waddell MB, Rock CO, Lee RE, White SW. The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorganic & Medicinal Chemistry. 22: 2157-65. PMID 24613625 DOI: 10.1016/J.Bmc.2014.02.022 |
0.339 |
|
| 2014 |
Lee RE, Hurdle JG, Liu J, Bruhn DF, Matt T, Scherman MS, Vaddady PK, Zheng Z, Qi J, Akbergenov R, Das S, Madhura DB, Rathi C, Trivedi A, Villellas C, ... Lee RB, et al. Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux. Nature Medicine. 20: 152-8. PMID 24464186 DOI: 10.1038/Nm.3458 |
0.305 |
|
| 2011 |
Hurdle JG, O'Neill AJ, Chopra I, Lee RE. Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections. Nature Reviews. Microbiology. 9: 62-75. PMID 21164535 DOI: 10.1038/nrmicro2474 |
0.356 |
|
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