Tadashi Eguchi - Publications

Affiliations: 
1993 Kyushu University, Fukuoka-shi, Fukuoka-ken, Japan 
 1993-2001 Aichi Prefectural University, Nagakute-shi, Aichi-ken, Japan 
 2001- Fukuoka University 

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Year Citation  Score
2021 Sato S, Kudo F, Rohmer M, Eguchi T. Biochemical and Mutational Analysis of Radical -Adenosyl-L-Methionine Adenosylhopane Synthase HpnH from Reveals that the Conserved Residue Cysteine-106 Reduces a Radical Intermediate and Determines the Stereochemistry. Biochemistry. PMID 34506710 DOI: 10.1021/acs.biochem.1c00536  1
2021 Miyanaga A, Ouchi R, Kudo F, Eguchi T. Complex structure of the acyltransferase VinK and the carrier protein VinL with a pantetheine cross-linking probe. Acta Crystallographica. Section F, Structural Biology Communications. 77: 294-302. PMID 34473106 DOI: 10.1107/S2053230X21008761  1
2021 Takashima M, Watanabe I, Miyanaga A, Eguchi T. Substrate specificity of Chondroitinase ABC I based on analyses of biochemical reactions and crystal structures in complex with disaccharides. Glycobiology. PMID 34392362 DOI: 10.1093/glycob/cwab086  1
2021 Yamada Y, Fujinami K, Eguchi T, Takefuji H, Mori N. Multisystem Inflammatory Syndrome in Adults after Mild SARS-CoV-2 Infection, Japan. Emerging Infectious Diseases. 27. PMID 33821784 DOI: 10.3201/eid2706.210728  1
2021 Kudo F, Takahashi S, Miyanaga A, Nakazawa Y, Nishino K, Hayakawa Y, Kawamura K, Ishikawa F, Tanabe G, Iwai N, Nagumo Y, Usui T, Eguchi T. Mutational Biosynthesis of Hitachimycin Analogs Controlled by the β-Amino Acid-Selective Adenylation Enzyme HitB. Acs Chemical Biology. PMID 33625847 DOI: 10.1021/acschembio.1c00003  1
2021 Kudo F, Mori A, Koide M, Yajima R, Takeishi R, Miyanaga A, Eguchi T. One-pot enzymatic synthesis of 2-deoxy-scyllo-inosose from d-glucose and polyphosphate. Bioscience, Biotechnology, and Biochemistry. 85: 108-114. PMID 33577648 DOI: 10.1093/bbb/zbaa025  1
2021 Kudo F, Kitayama Y, Miyanaga A, Numakura M, Eguchi T. Stepwise Post-glycosylation Modification of Sugar Moieties in Kanamycin Biosynthesis. Chembiochem : a European Journal of Chemical Biology. PMID 33403742 DOI: 10.1002/cbic.202000839  1
2020 Miyanaga A, Kurihara S, Chisuga T, Kudo F, Eguchi T. Structural Characterization of Complex of Adenylation Domain and Carrier Protein by Using Pantetheine Cross-Linking Probe. Acs Chemical Biology. 15: 1808-1812. PMID 32608966 DOI: 10.1021/acschembio.0c00403  1
2020 Miyanaga A, Takaku R, Takaishi M, Tashiro E, Kudo F, Eguchi T. Generation of incednine derivatives by mutasynthesis. The Journal of Antibiotics. 73: 794-797. PMID 32499555 DOI: 10.1038/s41429-020-0329-y  1
2020 Maruyama C, Chinone Y, Sato S, Kudo F, Ohsawa K, Kubota J, Hashimoto J, Kozone I, Doi T, Shin-Ya K, Eguchi T, Hamano Y. -Methylation of -adenosyl-L-Methionine Occurs Prior to Cyclopropanation in the Biosynthesis of 1-Amino-2-Methylcyclopropanecarboxylic Acid (Norcoronamic Acid) in a Bacterium. Biomolecules. 10. PMID 32429436 DOI: 10.3390/biom10050775  1
2020 Kudo F, Kitayama Y, Miyanaga A, Hirayama A, Eguchi T. Biochemical and Structural Analysis of a Dehydrogenase, KanD2, and an Aminotransferase, KanS2, That Are Responsible for the Construction of the Kanosamine Moiety in Kanamycin Biosynthesis. Biochemistry. 59: 1470-1473. PMID 32237736 DOI: 10.1021/acs.biochem.0c00204  1
2019 Kudo F, Tsunoda T, Yamaguchi K, Miyanaga A, Eguchi T. Stereochemistry in the Reaction of the -Inositol Phosphate Synthase Ortholog Ari2 during Aristeromycin Biosynthesis. Biochemistry. PMID 31825604 DOI: 10.1021/acs.biochem.9b00981  1
2019 Kawasaki D, Miyanaga A, Chisuga T, Kudo F, Eguchi T. Functional and Structural Analyses of the Split-Dehydratase Domain in the Biosynthesis of Macrolactam Polyketide Cremimycin. Biochemistry. 58: 4799-4803. PMID 31721563 DOI: 10.1021/acs.biochem.9b00897  1
2019 Sato S, Kudo F, Rohmer M, Eguchi T. Characterization of Radical SAM Adenosylhopane Synthase, HpnH, which Catalyzes the 5'-Deoxyadenosyl Radical Addition to Diploptene in the Biosynthesis of C35 Bacteriohopanepolyols. Angewandte Chemie (International Ed. in English). PMID 31657500 DOI: 10.1002/anie.201911584  1
2019 Kawasaki D, Chisuga T, Miyanaga A, Kudo F, Eguchi T. Structural Analysis of the Glycine Oxidase Homolog CmiS2 Reveals a Unique Substrate Recognition Mechanism for Formation of a β-Amino Acid Starter Unit in Cremimycin Biosynthesis. Biochemistry. PMID 31154757 DOI: 10.1021/acs.biochem.9b00444  1
2019 Zhang X, Chen W, Gao Q, Yang J, Yan X, Zhao H, Su L, Yang M, Gao C, Yao Y, Inoki K, Li D, Shao R, Wang S, Sahoo N, ... ... Eguchi T, et al. Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR. Plos Biology. 17: e3000252. PMID 31112550 DOI: 10.1371/Journal.Pbio.3000252  1
2019 Kudo F, Zhang J, Sato S, Hirayama A, Eguchi T. Functional Characterization of 3-Aminobenzoic Acid Adenylation Enzyme PctU and UDP-N-Acetyl-D-Glucosamine: 3-Aminobenzoyl-ACP Glycosyltransferase PctL in Pactamycin Biosynthesis. Chembiochem : a European Journal of Chemical Biology. PMID 31059166 DOI: 10.1002/cbic.201900239  1
2019 Cieślak J, Miyanaga A, Takaishi M, Kudo F, Eguchi T. Functional and structural characterization of IdnL7, an adenylation enzyme involved in incednine biosynthesis. Acta Crystallographica. Section F, Structural Biology Communications. 75: 299-306. PMID 30950831 DOI: 10.1107/S2053230X19002863  1
2019 Ishikawa F, Miyanaga A, Kitayama H, Nakamura S, Nakanishi I, Kudo F, Eguchi T, Tanabe G. An engineered aryl acid adenylation domain with a capacious active site microenvironment. Angewandte Chemie (International Ed. in English). PMID 30945421 DOI: 10.1002/anie.201900318  1
2019 Kudo F, Miyanaga A, Eguchi T. Structural basis of the nonribosomal codes for nonproteinogenic amino acid selective adenylation enzymes in the biosynthesis of natural products. Journal of Industrial Microbiology & Biotechnology. 46: 515-536. PMID 30291534 DOI: 10.1007/s10295-018-2084-7  1
2018 Miyanaga A, Kudo F, Eguchi T. Protein-protein interactions in polyketide synthase-nonribosomal peptide synthetase hybrid assembly lines. Natural Product Reports. 35: 1185-1209. PMID 30074030 DOI: 10.1039/c8np00022k  1
2018 Sato S, Miyanaga A, Kim SY, Kuzuyama T, Kudo F, Eguchi T. Biochemical and Structural Analysis of FomD that Catalyzes the Hydrolysis of Cytidylyl (S)-2-Hydroxypropylphosphonate in Fosfomycin Biosynthesis. Biochemistry. PMID 30010320 DOI: 10.1021/acs.biochem.8b00690  1
2018 Sato S, Kudo F, Kuzuyama T, Hammerschmidt F, Eguchi T. C-Methylation Catalyzed by Fom3, a Cobalamin-dependent Radical SAM Enzyme in Fosfomycin Biosynthesis, Proceeds with Inversion of Configuration. Biochemistry. PMID 29966085 DOI: 10.1021/acs.biochem.8b00614  1
2018 Miyanaga A, Ouchi R, Ishikawa F, Goto E, Tanabe G, Kudo F, Eguchi T. Structural basis of protein-protein interactions between a trans-acting acyltransferase and acyl carrier protein in polyketide disorazole biosynthesis. Journal of the American Chemical Society. PMID 29870659 DOI: 10.1021/jacs.8b04162  1
2018 Watanabe S, Ozawa H, Kato H, Nimura-Matsune K, Hirayama T, Kudo F, Eguchi T, Kakinuma K, Yoshikawa H. Carbon-free production of 2-deoxy-scyllo-inosose (DOI) in cyanobacterium Synechococcus elongatus PCC 7942. Bioscience, Biotechnology, and Biochemistry. 1-5. PMID 29297252 DOI: 10.1080/09168451.2017.1411777  1
2017 Hirayama A, Chu J, Goto E, Kudo F, Eguchi T. NAD+-dependent dehydrogenase PctP and PLP-dependent aminotransferase PctC catalyze the first post-glycosylation modification of sugar intermediate in pactamycin biosynthesis. Chembiochem : a European Journal of Chemical Biology. PMID 29148266 DOI: 10.1002/cbic.201700483  1
2017 Miyanaga A, Takayanagi R, Furuya T, Kawamata A, Itagaki T, Iwabuchi Y, Kanoh N, Kudo F, Eguchi T. Substrate Recognition by a Dual-Function P450 Monooxygenase GfsF Involved in FD-891 Biosynthesis. Chembiochem : a European Journal of Chemical Biology. 18: 2179-2187. PMID 28869713 DOI: 10.1002/cbic.201700429  1
2017 Cho SH, Kim SY, Tomita T, Shiraishi T, Park JS, Sato S, Kudo F, Eguchi T, Funa N, Nishiyama M, Kuzuyama T. Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme. Acs Chemical Biology. PMID 28727444 DOI: 10.1021/acschembio.7b00419  1
2017 Sato S, Kudo F, Kim SY, Kuzuyama T, Eguchi T. Methylcobalamin-dependent Radical SAM C-Methyltransferase Fom3 Recognizes Cytidylyl-2-hydroxyethylphosphonate and Catalyzes the Non-stereoselective C-Methylation in Fosfomycin Biosynthesis. Biochemistry. PMID 28678474 DOI: 10.1021/acs.biochem.7b00472  1
2017 Amagai K, Ikeda H, Hashimoto J, Kozone I, Izumikawa M, Kudo F, Eguchi T, Nakamura T, Osada H, Takahashi S, Shin-Ya K. Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host. Scientific Reports. 7: 3382. PMID 28611443 DOI: 10.1038/s41598-017-03308-5  1
2017 Chisuga T, Miyanaga A, Kudo F, Eguchi T. Structural analysis of the dual-function thioesterase SAV606 unravels the mechanism of Michael addition of glycine to an α,β-unsaturated thioester. The Journal of Biological Chemistry. 292: 10926-10937. PMID 28522606 DOI: 10.1074/jbc.M117.792549  1
2017 Cieślak J, Miyanaga A, Takaku R, Takaishi M, Amagai K, Kudo F, Eguchi T. Biochemical characterization and structural insight into aliphatic β-amino acid adenylation enzymes IdnL1 and CmiS6. Proteins. 85: 1238-1247. PMID 28316096 DOI: 10.1002/prot.25284  1
2017 Kudo F, Tokumitsu T, Eguchi T. Substrate specificity of radical S-adenosyl-l-methionine dehydratase AprD4 and its partner reductase AprD3 in the C3'-deoxygenation of aminoglycoside antibiotics. The Journal of Antibiotics. 70: 423-428. PMID 27599765 DOI: 10.1038/ja.2016.110  1
2016 Miyanaga A, Kudo F, Eguchi T. Mechanisms of β-amino acid incorporation in polyketide macrolactam biosynthesis. Current Opinion in Chemical Biology. 35: 58-64. PMID 27619002 DOI: 10.1016/j.cbpa.2016.08.030  1
2016 Kudo F, Tsunoda T, Takashima M, Eguchi T. Five-Membered Cyclitol Phosphate Formation by a myo-Inositol Phosphate Synthase Orthologue in the Biosynthesis of the Carbocyclic Nucleoside Antibiotic Aristeromycin. Chembiochem : a European Journal of Chemical Biology. 17: 2143-2148. PMID 27577857 DOI: 10.1002/cbic.201600348  1
2016 Nishiyama Y, Ohmichi T, Kazami S, Iwasaki H, Mano K, Nagumo Y, Kudo F, Ichikawa S, Iwabuchi Y, Kanoh N, Eguchi T, Osada H, Usui T. Vicenistatin induces early endosome-derived vacuole formation in mammalian cells. Bioscience, Biotechnology, and Biochemistry. 80: 902-10. PMID 27104762 DOI: 10.1080/09168451.2015.1132152  1
2016 Kudo F, Matsuura Y, Hayashi T, Fukushima M, Eguchi T. Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase. The Journal of Antibiotics. PMID 27072286 DOI: 10.1038/ja.2016.40  1
2016 Miyanaga A, Iwasawa S, Shinohara Y, Kudo F, Eguchi T. Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831085 DOI: 10.1073/pnas.1520042113  1
2016 Miyanaga A, Hayakawa Y, Numakura M, Hashimoto J, Teruya K, Hirano T, Shin-Ya K, Kudo F, Eguchi T. Identification of the Fluvirucin B2 (Sch 38518) Biosynthetic Gene Cluster from Actinomadura fulva subsp. indica ATCC 53714: substrate Specificity of the β-Amino Acid Selective Adenylating Enzyme FlvN. Bioscience, Biotechnology, and Biochemistry. 1-7. PMID 26818633 DOI: 10.1080/09168451.2015.1132155  1
2016 Itagaki T, Kawamata A, Takeuchi M, Hamada K, Iwabuchi Y, Eguchi T, Kudo F, Usui T, Kanoh N. Synthesis and structure-activity relationship study of FD-891: importance of the side chain and C8-C9 epoxide for cytotoxic activity against cancer cells. The Journal of Antibiotics. 69: 287-93. PMID 26814671 DOI: 10.1038/ja.2015.148  1
2016 Kudo F, Eguchi T. Aminoglycoside Antibiotics: New Insights into the Biosynthetic Machinery of Old Drugs. Chemical Record (New York, N.Y.). 16: 4-18. PMID 26455715 DOI: 10.1002/tcr.201500210  1
2015 Eguchi T, Kudo F, Kawamura K, Furuya T, Yamanishi H, Motegi A, Komatsubara A, Numakura M, Miyanaga A. Parallel Post-Polyketide Synthase Modification Mechanism Involved in FD-891 Biosynthesis in Streptomyces graminofaciens A-8890. Chembiochem : a European Journal of Chemical Biology. PMID 26630077 DOI: 10.1002/cbic.201500533  1
2015 Hirayama A, Miyanaga A, Kudo F, Eguchi T. Mechanism-Based Trapping of the Quinonoid Intermediate by Using the K276R Mutant of PLP-Dependent 3-Aminobenzoate Synthase PctV in the Biosynthesis of Pactamycin. Chembiochem : a European Journal of Chemical Biology. 16: 2484-90. PMID 26426567 DOI: 10.1002/cbic.201500426  1
2015 Kudo F, Kawamura K, Uchino A, Miyanaga A, Numakura M, Takayanagi R, Eguchi T. Genome mining of the hitachimycin biosynthetic gene cluster: involvement of a phenylalanine-2,3-aminomutase in biosynthesis. Chembiochem : a European Journal of Chemical Biology. 16: 909-14. PMID 25786909 DOI: 10.1002/cbic.201500040  1
2015 Yamada Y, Arima S, Nagamitsu T, Johmoto K, Uekusa H, Eguchi T, Shin-Ya K, Cane DE, Ikeda H. Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host. The Journal of Antibiotics. 68: 385-94. PMID 25605043 DOI: 10.1038/Ja.2014.171  1
2015 Takeishi R, Kudo F, Numakura M, Eguchi T. Epimerization at C-3'' in butirosin biosynthesis by an NAD(+) -dependent dehydrogenase BtrE and an NADPH-dependent reductase BtrF. Chembiochem : a European Journal of Chemical Biology. 16: 487-95. PMID 25600434 DOI: 10.1002/cbic.201402612  1
2014 Eguchi T. [Sumiki-Umezawa Memorial Lectures (2013 Award Lectures). Mechanistic enzymology of biosynthetic enzymes for microbial secondary metabolites]. The Japanese Journal of Antibiotics. 67: 253-62. PMID 25420322  0.01
2014 Miyanaga A, Cieślak J, Shinohara Y, Kudo F, Eguchi T. The crystal structure of the adenylation enzyme VinN reveals a unique β-amino acid recognition mechanism. The Journal of Biological Chemistry. 289: 31448-57. PMID 25246523 DOI: 10.1074/jbc.M114.602326  1
2014 Kudo F, Hoshi S, Kawashima T, Kamachi T, Eguchi T. Characterization of a radical S-adenosyl-L-methionine epimerase, NeoN, in the last step of neomycin B biosynthesis. Journal of the American Chemical Society. 136: 13909-15. PMID 25230155 DOI: 10.1021/ja507759f  1
2014 Kudo F, Miyanaga A, Eguchi T. Biosynthesis of natural products containing β-amino acids. Natural Product Reports. 31: 1056-73. PMID 24926851 DOI: 10.1039/c4np00007b  1
2014 Shinohara Y, Miyanaga A, Kudo F, Eguchi T. The crystal structure of the amidohydrolase VinJ shows a unique hydrophobic tunnel for its interaction with polyketide substrates. Febs Letters. 588: 995-1000. PMID 24530530 DOI: 10.1016/j.febslet.2014.01.060  1
2013 Koide M, Miyanaga A, Kudo F, Eguchi T. Characterization of polyphosphate glucokinase SCO5059 from Streptomyces coelicolor A3(2). Bioscience, Biotechnology, and Biochemistry. 77: 2322-4. PMID 24200789 DOI: 10.1271/bbb.130498  1
2013 Amagai K, Takaku R, Kudo F, Eguchi T. A unique amino transfer mechanism for constructing the β-amino fatty acid starter unit in the biosynthesis of the macrolactam antibiotic cremimycin. Chembiochem : a European Journal of Chemical Biology. 14: 1998-2006. PMID 24014395 DOI: 10.1002/cbic.201300370  1
2013 Takaishi M, Kudo F, Eguchi T. Identification of the incednine biosynthetic gene cluster: characterization of novel β-glutamate-β-decarboxylase IdnL3. The Journal of Antibiotics. 66: 691-9. PMID 23921821 DOI: 10.1038/ja.2013.76  1
2013 Itagaki S, Haga M, Oikawa Y, Sakoda A, Ohke Y, Sawada H, Eguchi T, Tamegai H. Differences in the roles of a glutamine amidotransferase subunit of pyridoxal 5'-phosphate synthase between Bacillus circulans and Bacillus subtilis. Bioscience, Biotechnology, and Biochemistry. 77: 1481-5. PMID 23832367 DOI: 10.1271/bbb.130132  1
2013 Hirayama A, Eguchi T, Kudo F. A single PLP-dependent enzyme PctV catalyzes the transformation of 3-dehydroshikimate into 3-aminobenzoate in the biosynthesis of pactamycin. Chembiochem : a European Journal of Chemical Biology. 14: 1198-203. PMID 23744829 DOI: 10.1002/cbic.201300153  1
2012 Fukuda H, Nishiyama Y, Nakamura S, Ohno Y, Eguchi T, Iwabuchi Y, Usui T, Kanoh N. Synthesis and structure-activity relationship of vicenistatin, a cytotoxic 20-membered macrolactam glycoside. Chemistry, An Asian Journal. 7: 2872-81. PMID 23015368 DOI: 10.1002/asia.201200615  1
2012 Takaishi M, Kudo F, Eguchi T. A unique pathway for the 3-aminobutyrate starter unit from L-glutamate through β-glutamate during biosynthesis of the 24-membered macrolactam antibiotic, incednine. Organic Letters. 14: 4591-3. PMID 22928983 DOI: 10.1021/ol302052c  1
2012 Sucipto H, Kudo F, Eguchi T. The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the α-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK. Angewandte Chemie (International Ed. in English). 51: 3428-31. PMID 22374809 DOI: 10.1002/anie.201108122  1
2011 Nakano C, Kudo F, Eguchi T, Ohnishi Y. Genome mining reveals two novel bacterial sesquiterpene cyclases: (-)-germacradien-4-ol and (-)-epi-α-bisabolol synthases from Streptomyces citricolor. Chembiochem : a European Journal of Chemical Biology. 12: 2271-5. PMID 23106076 DOI: 10.1002/cbic.201100418  1
2011 Shinohara Y, Kudo F, Eguchi T. A natural protecting group strategy to carry an amino acid starter unit in the biosynthesis of macrolactam polyketide antibiotics. Journal of the American Chemical Society. 133: 18134-7. PMID 22010945 DOI: 10.1021/ja208927r  1
2011 Nango E, Yamamoto T, Kumasaka T, Eguchi T. Structure of Thermus thermophilus homoisocitrate dehydrogenase in complex with a designed inhibitor. Journal of Biochemistry. 150: 607-14. PMID 21813504 DOI: 10.1093/jb/mvr097  1
2011 Hoshino T, Nango E, Baba S, Eguchi T, Kumasaka T. Crystallization and preliminary X-ray analysis of isopentenyl diphosphate isomerase from Methanocaldococcus jannaschii. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 101-3. PMID 21206036 DOI: 10.1107/S1744309110046944  1
2011 Kudo F, Yonezawa T, Komatsubara A, Mizoue K, Eguchi T. Cloning of the biosynthetic gene cluster for naphthoxanthene antibiotic FD-594 from Streptomyces sp. TA-0256. The Journal of Antibiotics. 64: 123-32. PMID 21102601 DOI: 10.1038/ja.2010.145  1
2010 Xu Q, Eguchi T, Mathews II, Rife CL, Chiu HJ, Farr CL, Feuerhelm J, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Weekes D, Elsliger MA, Deacon AM, Godzik A, et al. Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids. Journal of Molecular Biology. 404: 403-17. PMID 20869368 DOI: 10.1016/J.Jmb.2010.09.032  1
2010 Kudo F, Motegi A, Mizoue K, Eguchi T. Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation. Chembiochem : a European Journal of Chemical Biology. 11: 1574-82. PMID 20589823 DOI: 10.1002/cbic.201000214  1
2010 Tamegai H, Sawada H, Nango E, Aoki R, Hirakawa H, Iino T, Eguchi T. Roles of a 20 kDa protein associated with a carbocycle-forming enzyme involved in aminoglycoside biosynthesis in primary and secondary metabolism. Bioscience, Biotechnology, and Biochemistry. 74: 1215-9. PMID 20530911 DOI: 10.1271/bbb.90961  1
2009 Kudo F, Sucipto H, Eguchi T. Enzymatic activity of a glycosyltransferase KanM2 encoded in the kanamycin biosynthetic gene cluster. The Journal of Antibiotics. 62: 707-10. PMID 19911031 DOI: 10.1038/ja.2009.107  1
2009 Nango E, Yamamoto T, Kumasaka T, Eguchi T. Crystal structure of 3-isopropylmalate dehydrogenase in complex with NAD(+) and a designed inhibitor. Bioorganic & Medicinal Chemistry. 17: 7789-94. PMID 19833522 DOI: 10.1016/j.bmc.2009.09.025  1
2009 Kudo F, Kawashima T, Yokoyama K, Eguchi T. Enzymatic preparation of neomycin C from ribostamycin. The Journal of Antibiotics. 62: 643-6. PMID 19713992 DOI: 10.1038/Ja.2009.88  1
2009 Kudo F, Eguchi T. Biosynthetic genes for aminoglycoside antibiotics. The Journal of Antibiotics. 62: 471-81. PMID 19644520 DOI: 10.1038/ja.2009.76  1
2009 Inaba S, Eguchi T, Motegi A, Mizoue K, Usui T, Nagai K, Kataoka T. The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells. The Journal of Antibiotics. 62: 507-12. PMID 19590527 DOI: 10.1038/ja.2009.62  1
2009 Kudo F, Eguchi T. Biosynthetic enzymes for the aminoglycosides butirosin and neomycin. Methods in Enzymology. 459: 493-519. PMID 19362652 DOI: 10.1016/S0076-6879(09)04620-5  1
2008 Yokoyama K, Ohmori D, Kudo F, Eguchi T. Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy. Biochemistry. 47: 8950-60. PMID 18672902 DOI: 10.1021/Bi800509X  1
2008 Nango E, Minami A, Kumasaka T, Eguchi T. Crystallization and preliminary X-ray analysis of vicenisaminyltransferase VinC. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 64: 558-60. PMID 18540075 DOI: 10.1107/S1744309108014681  1
2008 Lin Y, Volkman J, Nicholas KM, Yamamoto T, Eguchi T, Nimmo SL, West AH, Cook PF. Chemical mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 47: 4169-80. PMID 18321070 DOI: 10.1021/Bi702361J  1
2008 Yokoyama K, Yamamoto Y, Kudo F, Eguchi T. Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis. Chembiochem : a European Journal of Chemical Biology. 9: 865-9. PMID 18311744 DOI: 10.1002/Cbic.200700717  1
2008 Nango E, Kumasaka T, Hirayama T, Tanaka N, Eguchi T. Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+. Proteins. 70: 517-27. PMID 17879343 DOI: 10.1002/prot.21526  1
2007 Yokoyama K, Numakura M, Kudo F, Ohmori D, Eguchi T. Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin. Journal of the American Chemical Society. 129: 15147-55. PMID 18001019 DOI: 10.1021/Ja072481T  1
2007 Hoshino T, Eguchi T. Functional analysis of type 1 isopentenyl diphosphate isomerase from Halobacterium sp. NRC-1. Bioscience, Biotechnology, and Biochemistry. 71: 2588-91. PMID 17928693 DOI: 10.1271/bbb.70330  1
2007 Kudo F, Kasama Y, Hirayama T, Eguchi T. Cloning of the pactamycin biosynthetic gene cluster and characterization of a crucial glycosyltransferase prior to a unique cyclopentane ring formation. The Journal of Antibiotics. 60: 492-503. PMID 17827660 DOI: 10.1038/ja.2007.63  1
2007 Kudo F, Fujii T, Kinoshita S, Eguchi T. Unique O-ribosylation in the biosynthesis of butirosin. Bioorganic & Medicinal Chemistry. 15: 4360-8. PMID 17482823 DOI: 10.1016/j.bmc.2007.04.040  1
2007 Morii H, Eguchi T, Koga Y. In vitro biosynthesis of ether-type glycolipids in the methanoarchaeon Methanothermobacter thermautotrophicus. Journal of Bacteriology. 189: 4053-61. PMID 17416653 DOI: 10.1128/JB.01875-06  0.01
2007 Minami A, Eguchi T. Substrate flexibility of vicenisaminyltransferase VinC involved in the biosynthesis of vicenistatin. Journal of the American Chemical Society. 129: 5102-7. PMID 17388594 DOI: 10.1021/ja0685250  1
2007 Nishimura Y, Eguchi T. Stereochemistry of reduction in digeranylgeranylglycerophospholipid reductase involved in the biosynthesis of archaeal membrane lipids from Thermoplasma acidophilum. Bioorganic Chemistry. 35: 276-83. PMID 17275067 DOI: 10.1016/j.bioorg.2006.12.001  1
2007 Fraser PD, Enfissi EM, Goodfellow M, Eguchi T, Bramley PM. Metabolite profiling of plant carotenoids using the matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The Plant Journal : For Cell and Molecular Biology. 49: 552-64. PMID 17217472 DOI: 10.1111/j.1365-313X.2006.02949.x  0.04
2007 Hirayama T, Kudo F, Huang Z, Eguchi T. Role of glutamate 243 in the active site of 2-deoxy-scyllo-inosose synthase from Bacillus circulans. Bioorganic & Medicinal Chemistry. 15: 418-23. PMID 17035031 DOI: 10.1016/j.bmc.2006.09.042  1
2006 Hirayama T, Tamegai H, Kudo F, Kojima K, Kakinuma K, Eguchi T. Biosynthesis of 2-deoxystreptamine-containing antibiotics in Streptoalloteichus hindustanus JCM 3268: characterization of 2-deoxy-scyllo-inosose synthase. The Journal of Antibiotics. 59: 358-61. PMID 16915821 DOI: 10.1038/ja.2006.51  1
2006 Hoshino T, Tamegai H, Kakinuma K, Eguchi T. Inhibition of type 2 isopentenyl diphosphate isomerase from Methanocaldococcus jannaschii by a mechanism-based inhibitor of type 1 isopentenyl diphosphate isomerase. Bioorganic & Medicinal Chemistry. 14: 6555-9. PMID 16793276 DOI: 10.1016/j.bmc.2006.06.011  1
2006 Nishimura Y, Eguchi T. Biosynthesis of archaeal membrane lipids: digeranylgeranylglycerophospholipid reductase of the thermoacidophilic archaeon Thermoplasma acidophilum. Journal of Biochemistry. 139: 1073-81. PMID 16788058 DOI: 10.1093/jb/mvj118  1
2006 Tohyama S, Kakinuma K, Eguchi T. The complete biosynthetic gene cluster of the 28-membered polyketide macrolactones, halstoctacosanolides, from Streptomyces halstedii HC34. The Journal of Antibiotics. 59: 44-52. PMID 16568718 DOI: 10.1038/ja.2006.7  1
2005 Nango E, Kumasaka T, Sato T, Tanaka N, Kakinuma K, Eguchi T. Crystallization and X-ray analysis of 2-deoxy-scyllo-inosose synthase, the key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 709-11. PMID 16511136 DOI: 10.1107/S1744309105018841  1
2005 Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K. Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773. The Journal of Antibiotics. 58: 766-74. PMID 16506694 DOI: 10.1038/Ja.2005.104  1
2005 Ogasawara Y, Kakinuma K, Eguchi T. Involvement of glutamate mutase in the biosynthesis of the unique starter unit of the macrolactam polyketide antibiotic vicenistatin. The Journal of Antibiotics. 58: 468-72. PMID 16161486 DOI: 10.1038/Ja.2005.62  1
2005 Kudo F, Numakura M, Tamegai H, Yamamoto H, Eguchi T, Kakinuma K. Extended sequence and functional analysis of the butirosin biosynthetic gene cluster in Bacillus circulans SANK 72073. The Journal of Antibiotics. 58: 373-9. PMID 16156513 DOI: 10.1038/ja.2005.47  1
2005 Minami A, Uchida R, Eguchi T, Kakinuma K. Enzymatic approach to unnatural glycosides with diverse aglycon scaffolds using glycosyltransferase VinC. Journal of the American Chemical Society. 127: 6148-9. PMID 15853301 DOI: 10.1021/ja042848j  1
2005 Yokoyama K, Kudo F, Kuwahara M, Inomata K, Tamegai H, Eguchi T, Kakinuma K. Stereochemical recognition of doubly functional aminotransferase in 2-deoxystreptamine biosynthesis. Journal of the American Chemical Society. 127: 5869-74. PMID 15839685 DOI: 10.1021/Ja0445948  1
2005 Huang Z, Kakinuma K, Eguchi T. Stereospecificity of hydride transfer in NAD+-catalyzed 2-deoxy-scyllo-inosose synthase, the key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics. Bioorganic Chemistry. 33: 82-9. PMID 15788164 DOI: 10.1016/j.bioorg.2004.09.002  1
2005 Kudo F, Kawabe K, Kuriki H, Eguchi T, Kakinuma K. A new family of glucose-1-phosphate/glucosamine-1-phosphate nucleotidylyltransferase in the biosynthetic pathways for antibiotics. Journal of the American Chemical Society. 127: 1711-8. PMID 15701005 DOI: 10.1021/ja044921b  1
2004 Ogasawara Y, Katayama K, Minami A, Otsuka M, Eguchi T, Kakinuma K. Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii. Chemistry & Biology. 11: 79-86. PMID 15112997 DOI: 10.1016/J.Chembiol.2003.12.010  1
2004 Eguchi T, Yamamoto K, Mizoue K, Kakinuma K. Structure revision of FD-891, a 16-membered macrolide antibiotic. The Journal of Antibiotics. 57: 156-7. PMID 15112965 DOI: 10.7164/antibiotics.57.156  1
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