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Amit Choudhary - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
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56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Nguyen TM, Sreekanth V, Deb A, Kokkonda P, Tiwari PK, Donovan KA, Shoba V, Chaudhary SK, Mercer JAM, Lai S, Sadagopan A, Jan M, Fischer ES, Liu DR, Ebert BL, ... Choudhary A, et al. Proteolysis-targeting chimeras with reduced off-targets. Nature Chemistry. PMID 38110475 DOI: 10.1038/s41557-023-01379-8  0.781
2023 Gibson WJ, Sadagopan A, Shoba VM, Choudhary A, Meyerson M, Schreiber SL. Bifunctional Small Molecules That Induce Nuclear Localization and Targeted Transcriptional Regulation. Journal of the American Chemical Society. PMID 37992275 DOI: 10.1021/jacs.3c06179  0.803
2023 Kahraman S, Shibue K, De Jesus DF, Kim H, Hu J, Manna D, Wagner BK, Choudhary A, Kulkarni RN. Fluorescein-based sensors to purify human a-cells for functional and transcriptomic analyses. Elife. 12. PMID 37732504 DOI: 10.7554/eLife.85056  0.592
2023 Pergu R, Shoba VM, Chaudhary SK, Munkanatta Godage DNP, Deb A, Singha S, Dhawa U, Singh P, Anokhina V, Singh S, Siriwardena SU, Choudhary A. Development and Applications of Chimera Platforms for Tyrosine Phosphorylation. Acs Central Science. 9: 1558-1566. PMID 37637727 DOI: 10.1021/acscentsci.3c00200  0.776
2023 Singh S, Tian W, Severance ZC, Chaudhary SK, Anokhina V, Mondal B, Pergu R, Singh P, Dhawa U, Singha S, Choudhary A. Proximity-inducing modalities: the past, present, and future. Chemical Society Reviews. PMID 37477631 DOI: 10.1039/d2cs00943a  0.758
2023 Gibson WJ, Sadagopan A, Shoba VM, Choudhary A, Meyerson M, Schreiber SL. Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation. Biorxiv : the Preprint Server For Biology. PMID 37461636 DOI: 10.1101/2023.07.07.548101  0.803
2023 Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, ... ... Choudhary A, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Cell Metabolism. PMID 37075753 DOI: 10.1016/j.cmet.2023.03.018  0.778
2023 Arp CJ, Reynders M, Sreekanth V, Kokkonda P, Pagano M, Choudhary A, Trauner D. Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation. Biorxiv : the Preprint Server For Biology. PMID 37066279 DOI: 10.1101/2023.04.09.536172  0.783
2023 Sreekanth V, Jan M, Zhao KT, Lim D, Davis JR, McConkey M, Kovalcik V, Barkal S, Law BK, Fife J, Tian R, Vinyard ME, Becerra B, Kampmann ME, Sherwood RI, ... ... Choudhary A, et al. A molecular glue approach to control the half-life of CRISPR-based technologies. Biorxiv : the Preprint Server For Biology. PMID 36945568 DOI: 10.1101/2023.03.12.531757  0.791
2023 Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, ... ... Choudhary A, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Biorxiv : the Preprint Server For Biology. PMID 36865221 DOI: 10.1101/2023.02.19.529127  0.782
2022 Lim D, Zhou Q, Cox KJ, Law BK, Lee M, Kokkonda P, Sreekanth V, Pergu R, Chaudhary SK, Gangopadhyay SA, Maji B, Lai S, Amako Y, Thompson DB, Subramanian HKK, ... ... Choudhary A, et al. A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules. Nature Cell Biology. PMID 36396978 DOI: 10.1038/s41556-022-01005-8  0.756
2022 Shoba VM, Munkanatta Godage DNP, Chaudhary SK, Deb A, Siriwardena SU, Choudhary A. Synthetic Reprogramming of Kinases Expands Cellular Activities of Proteins. Angewandte Chemie (International Ed. in English). e202202770. PMID 35641438 DOI: 10.1002/anie.202202770  0.794
2022 Yamada K, Deb A, Shoba VM, Lim D, Maji B, Modell AE, Choudhary A. Rational Design of Silicon-Based Zinc Ionophores. Angewandte Chemie (International Ed. in English). e202201698. PMID 35385189 DOI: 10.1002/anie.202201698  0.758
2021 Modell AE, Lim D, Nguyen TM, Sreekanth V, Choudhary A. CRISPR-based therapeutics: current challenges and future applications. Trends in Pharmacological Sciences. PMID 34952739 DOI: 10.1016/j.tips.2021.10.012  0.793
2021 Modell AE, Lai S, Nguyen TM, Choudhary A. Bifunctional modalities for repurposing protein function. Cell Chemical Biology. 28: 1081-1089. PMID 34270935 DOI: 10.1016/j.chembiol.2021.06.005  0.808
2021 Clemons PA, Bittker JA, Wagner FF, Hands A, Dančík V, Schreiber SL, Choudhary A, Wagner BK. The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes. Slas Discovery : Advancing Life Sciences R & D. 24725552211019410. PMID 34130532 DOI: 10.1177/24725552211019410  0.435
2021 Kahraman S, Manna D, Dirice E, Maji B, Small J, Wagner BK, Choudhary A, Kulkarni RN. Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells. Life Science Alliance. 4. PMID 33514654 DOI: 10.26508/lsa.202000840  0.778
2020 Cox KJ, Subramanian HKK, Samaniego CC, Franco E, Choudhary A. Correction: A universal method for sensitive and cell-free detection of CRISPR-associated nucleases. Chemical Science. 11: 10287. PMID 34094293 DOI: 10.1039/d0sc90196b  0.752
2020 Sreekanth V, Zhou Q, Kokkonda P, Bermudez-Cabrera HC, Lim D, Law BK, Holmes BR, Chaudhary SK, Pergu R, Leger BS, Walker JA, Gifford DK, Sherwood RI, Choudhary A. Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes. Acs Central Science. 6: 2228-2237. PMID 33376784 DOI: 10.1021/acscentsci.0c00129  0.755
2020 Modell AE, Siriwardena SU, Shoba VM, Li X, Choudhary A. clustered regularly interspaced short palindromic repeat-Chemical and optical control of CRISPR-associated nucleases. Current Opinion in Chemical Biology. 60: 113-121. PMID 33253976 DOI: 10.1016/j.cbpa.2020.10.003  0.779
2020 Yang K, Lee M, Jones PA, Liu SS, Zhou A, Xu J, Sreekanth V, Wu JLY, Vo L, Lee EA, Pop R, Lee Y, Wagner BK, Melton DA, Choudhary A, et al. A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells. Science Advances. 6. PMID 33208361 DOI: 10.1126/sciadv.abc3207  0.775
2020 Lim D, Sreekanth V, Cox KJ, Law BK, Wagner BK, Karp JM, Choudhary A. Engineering designer beta cells with a CRISPR-Cas9 conjugation platform. Nature Communications. 11: 4043. PMID 32792475 DOI: 10.1038/S41467-020-17725-0  0.789
2020 Siriwardena SU, Munkanatta Godage DNP, Shoba VM, Lai S, Shi M, Wu P, Chaudhary SK, Schreiber SL, Choudhary A. Phosphorylation-Inducing Chimeric Small Molecules. Journal of the American Chemical Society. PMID 32787262 DOI: 10.1021/Jacs.0C05537  0.791
2020 López Del Amo V, Leger BS, Cox KJ, Gill S, Bishop AL, Scanlon GD, Walker JA, Gantz VM, Choudhary A. Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives. Cell Reports. 31: 107841. PMID 32610142 DOI: 10.1016/J.Celrep.2020.107841  0.786
2020 Modell AE, Siriwardena SU, Choudhary A. A Jumbo Phage Forms a Nucleus-like Compartment to Evade Bacterial Defense Systems. Biochemistry. 59: 1869-1870. PMID 32403926 DOI: 10.1021/Acs.Biochem.0C00273  0.749
2020 Lee M, Maji B, Manna D, Kahraman S, Elgamal RM, Small J, Kokkonda P, Vetere A, Goldberg JM, Lippard SJ, Kulkarni RN, Wagner BK, Choudhary A. Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells. Journal of the American Chemical Society. PMID 32175731 DOI: 10.1021/Jacs.0C00099  0.768
2020 Cox KJ, Subramanian HKK, Samaniego CC, Franco E, Choudhary A. Correction: A universal method for sensitive and cell-free detection of CRISPR-associated nucleases Chemical Science. DOI: 10.1039/D0Sc90196B  0.763
2019 Maji B, Gangopadhyay SA, Lee M, Shi M, Wu P, Heler R, Mok B, Lim D, Siriwardena SU, Paul B, Dančík V, Vetere A, Mesleh MF, Marraffini LA, Liu DR, ... ... Choudhary A, et al. A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9. Cell. 177: 1067-1079.e19. PMID 31051099 DOI: 10.1016/J.Cell.2019.04.009  0.794
2019 Cox KJ, Subramanian HKK, Samaniego CC, Franco E, Choudhary A. A universal method for sensitive and cell-free detection of CRISPR-associated nucleases. Chemical Science. 10: 2653-2662. PMID 30996981 DOI: 10.1039/C8Sc03426E  0.791
2019 Choudhary A, Manna D, Maji B, Gangopadhyay SA, Cox KJ, Zhou Q, Law B, Mazitschek R. A singular system with precise dosing and spatiotemporal control of CRISPR-Cas9. Angewandte Chemie (International Ed. in English). PMID 30834641 DOI: 10.1002/Anie.201900788  0.789
2019 Gangopadhyay SA, Cox K, Manna D, Lim D, Maji B, Zhou Q, Choudhary A. Precision control of CRISPR-Cas9 using small molecules and light. Biochemistry. PMID 30640437 DOI: 10.1021/Acs.Biochem.8B01202  0.799
2016 Vasta JD, Choudhary A, Jensen KH, McGrath NA, Raines RT. Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond. Biochemistry. PMID 28001367 DOI: 10.1021/Acs.Biochem.6B00976  0.759
2016 Maji B, Moore CL, Zetsche B, Volz SE, Zhang F, Shoulders MD, Choudhary A. Multidimensional chemical control of CRISPR-Cas9. Nature Chemical Biology. PMID 27820801 DOI: 10.1038/Nchembio.2224  0.813
2015 Chou DH, Vetere A, Choudhary A, Scully SS, Schenone M, Tang A, Gomez R, Burns SM, Lundh M, Vital T, Comer E, Faloon PW, Dan?ík V, Ciarlo C, Paulk J, et al. Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling. Journal of the American Chemical Society. 137: 7929-34. PMID 26042473 DOI: 10.1021/Jacs.5B04284  0.557
2015 Choudhary A, Kamer KJ, Shoulders MD, Raines RT. 4-ketoproline: An electrophilic proline analog for bioconjugation. Biopolymers. 104: 110-5. PMID 25656588 DOI: 10.1002/Bip.22620  0.698
2014 Choudhary A, Newberry RW, Raines RT. n→π* interactions engender chirality in carbonyl groups. Organic Letters. 16: 3421-3. PMID 24926562 DOI: 10.1021/Ol5012967  0.733
2014 Choudhary A, Hu He K, Mertins P, Udeshi ND, Dan?ík V, Fomina-Yadlin D, Kubicek S, Clemons PA, Schreiber SL, Carr SA, Wagner BK. Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming. Plos One. 9: e95194. PMID 24759943 DOI: 10.1371/Journal.Pone.0095194  0.44
2013 Choudhary A, Fry CG, Kamer KJ, Raines RT. An n→π* interaction reduces the electrophilicity of the acceptor carbonyl group. Chemical Communications (Cambridge, England). 49: 8166-8. PMID 23928794 DOI: 10.1039/C3Cc44573A  0.462
2013 Guzei IA, Choudhary A, Raines RT. Pyramidalization of a carbonyl C atom in (2S)-N-(seleno-acet-yl)proline methyl ester. Acta Crystallographica. Section E, Structure Reports Online. 69: o805-6. PMID 23723945 DOI: 10.1107/S1600536813011112  0.439
2013 Kamer KJ, Choudhary A, Raines RT. Intimate interactions with carbonyl groups: dipole-dipole or n→π*? The Journal of Organic Chemistry. 78: 2099-103. PMID 23163960 DOI: 10.1021/Jo302265K  0.435
2012 Krow GR, Shoulders MD, Edupuganti R, Gandla D, Yu F, Sonnet PE, Sender M, Choudhary A, DeBrosse C, Ross CW, Carroll P, Raines RT. Synthesis of 5-fluoro- and 5-hydroxymethanoprolines via lithiation of N-BOC-methanopyrrolidines. Constrained Cγ-exo and Cγ-endo Flp and Hyp conformer mimics. The Journal of Organic Chemistry. 77: 5331-44. PMID 22607128 DOI: 10.1021/Jo300700A  0.68
2012 Choudhary A, Kamer KJ, Raines RT. A conserved interaction with the chromophore of fluorescent proteins. Protein Science : a Publication of the Protein Society. 21: 171-7. PMID 22057893 DOI: 10.1002/Pro.762  0.477
2011 Choudhary A, Kamer KJ, Raines RT. An n→π* interaction in aspirin: implications for structure and reactivity. The Journal of Organic Chemistry. 76: 7933-7. PMID 21842865 DOI: 10.1021/Jo201389D  0.458
2011 Choudhary A, Raines RT. An evaluation of peptide-bond isosteres. Chembiochem : a European Journal of Chemical Biology. 12: 1801-7. PMID 21751326 DOI: 10.1002/Cbic.201100272  0.466
2011 Krow GR, Edupuganti R, Gandla D, Yu F, Sender M, Sonnet PE, Zdilla MJ, DeBrosse C, Cannon KC, Ross CW, Choudhary A, Shoulders MD, Raines RT. Synthesis of conformationally constrained 5-fluoro- and 5-hydroxymethanopyrrolidines. Ring-puckered mimics of gauche- and anti-3-fluoro- and 3-hydroxypyrrolidines. The Journal of Organic Chemistry. 76: 3626-34. PMID 21500838 DOI: 10.1021/Jo200117P  0.681
2011 Choudhary A, Raines RT. Signature of n→π* interactions in α-helices. Protein Science : a Publication of the Protein Society. 20: 1077-81. PMID 21442680 DOI: 10.1002/Pro.627  0.449
2011 Choudhary A, Pua KH, Raines RT. Quantum mechanical origin of the conformational preferences of 4-thiaproline and its S-oxides. Amino Acids. 41: 181-6. PMID 20221839 DOI: 10.1007/S00726-010-0504-8  0.446
2010 Choudhary A, Fry CG, Raines RT. Modulation of an n→π* interaction with α-fluoro groups. Arkivoc : Free Online Journal of Organic Chemistry / Arkat-Usa, Inc. 2010: 251-262. PMID 21643549 DOI: 10.3998/Ark.5550190.0011.817  0.472
2010 Shoulders MD, Kotch FW, Choudhary A, Guzei IA, Raines RT. The aberrance of the 4S diastereomer of 4-hydroxyproline. Journal of the American Chemical Society. 132: 10857-65. PMID 20681719 DOI: 10.1021/Ja103082Y  0.764
2010 Bartlett GJ, Choudhary A, Raines RT, Woolfson DN. n-->pi* interactions in proteins. Nature Chemical Biology. 6: 615-20. PMID 20622857 DOI: 10.1038/Nchembio.406  0.479
2010 Choudhary A, Kamer KJ, Powner MW, Sutherland JD, Raines RT. A stereoelectronic effect in prebiotic nucleotide synthesis. Acs Chemical Biology. 5: 655-7. PMID 20499895 DOI: 10.1021/Cb100093G  0.471
2010 Jakobsche CE, Choudhary A, Miller SJ, Raines RT. n --> pi* Interaction and n)(pi Pauli repulsion are antagonistic for protein stability. Journal of the American Chemical Society. 132: 6651-3. PMID 20420451 DOI: 10.1021/Ja100931Y  0.463
2010 Choudhary A, Fry CG, Raines RT. Modulation of an np* interaction with a-fluoro groups Arkivoc. 2010: 251-262.  0.334
2009 Krow GR, Edupuganti R, Gandla D, Choudhary A, Lin G, Sonnet PE, DeBrosse C, Ross CW, Cannon KC, Raines RT. 5(6)-anti-Substituted-2-azabicyclo[2.1.1]hexanes: a nucleophilic displacement route. The Journal of Organic Chemistry. 74: 8232-42. PMID 19799411 DOI: 10.1021/Jo901725K  0.427
2009 Choudhary A, Gandla D, Krow GR, Raines RT. Nature of amide carbonyl--carbonyl interactions in proteins. Journal of the American Chemical Society. 131: 7244-6. PMID 19469574 DOI: 10.1021/Ja901188Y  0.482
2007 Prasad KR, Penchalaiah K, Choudhary A, Anbarasan P. Stereoselective synthesis of (-)-microcarpalide Tetrahedron Letters. 48: 309-311. DOI: 10.1016/J.Tetlet.2006.11.027  0.665
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