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Meredith E. Jackrel, Ph.D. - Publications

Affiliations: 
2010 Yale University, New Haven, CT 
Area:
Protein Structure, Function, and Design
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Chen S, Puri A, Bell B, Fritsche J, Palacios H, Balch M, Sprunger M, Howard M, Patterson J, Patti G, Davis A, Jackrel M. HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent. Research Square. PMID 37674720 DOI: 10.21203/rs.3.rs-2570571/v1  0.774
2023 Mack KL, Kim H, Barbieri EM, Lin J, Braganza S, Jackrel ME, DeNizio JE, Yan X, Chuang E, Tariq A, Cupo RR, Castellano LM, Caldwell KA, Caldwell GA, Shorter J. Tuning Hsp104 specificity to selectively detoxify α-synuclein. Molecular Cell. PMID 37625404 DOI: 10.1016/j.molcel.2023.07.029  0.816
2023 Shrimali PC, Chen S, Das A, Dreher R, Howard MK, Ryan JJ, Buck J, Kim D, Sprunger ML, Rudra JS, Jackrel ME. Amyloidogenic Propensity of Self-Assembling Peptides and their Adjuvant Potential for use as DNA Vaccines. Acta Biomaterialia. PMID 37586449 DOI: 10.1016/j.actbio.2023.08.015  0.777
2023 Howard MK, Miller KR, Sohn BS, Ryan JJ, Xu A, Jackrel ME. Probing the drivers of biofilm protein amyloidogenesis and disrupting biofilms with engineered protein disaggregases. Mbio. e0058723. PMID 37195208 DOI: 10.1128/mbio.00587-23  0.797
2022 Sprunger ML, Jackrel ME. Monitoring condensate dynamics in using fluorescence recovery after photobleaching. Star Protocols. 3: 101592. PMID 35928002 DOI: 10.1016/j.xpro.2022.101592  0.764
2022 Sprunger ML, Lee K, Sohn BS, Jackrel ME. Molecular determinants and modifiers of Matrin-3 toxicity, condensate dynamics, and droplet morphology. Iscience. 25: 103900. PMID 35252808 DOI: 10.1016/j.isci.2022.103900  0.819
2021 Sprunger ML, Jackrel ME. Prion-Like Proteins in Phase Separation and Their Link to Disease. Biomolecules. 11. PMID 34356638 DOI: 10.3390/biom11071014  0.789
2021 Ryan JJ, Bao A, Bell B, Ling C, Jackrel ME. Drivers of Hsp104 potentiation revealed by scanning mutagenesis of the middle domain. Protein Science : a Publication of the Protein Society. PMID 34010483 DOI: 10.1002/pro.4126  0.837
2020 March ZM, Sweeney K, Kim H, Yan X, Castellano LM, Jackrel ME, Lin J, Chuang E, Gomes E, Willicott CW, Michalska K, Jedrzejczak RP, Joachimiak A, Caldwell KA, Caldwell GA, et al. Therapeutic genetic variation revealed in diverse Hsp104 homologs. Elife. 9. PMID 33319748 DOI: 10.7554/eLife.57457  0.85
2020 Howard MK, Sohn BS, von Borcke J, Xu A, Jackrel ME. Functional analysis of proposed substrate-binding residues of Hsp104. Plos One. 15: e0230198. PMID 32155221 DOI: 10.1371/Journal.Pone.0230198  0.678
2020 Ryan J, Bao A, Bell B, Jackrel M. Mechanistic Insights into Potentiation of the AAA+ Disaggregase Hsp104 Biophysical Journal. 118: 337a. DOI: 10.1016/J.Bpj.2019.11.1880  0.816
2019 Ryan JJ, Sprunger ML, Holthaus K, Shorter J, Jackrel ME. Correction: Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma. The Journal of Biological Chemistry. 294: 17707. PMID 31732685 DOI: 10.1074/jbc.AAC119.011523  0.79
2019 Tariq A, Lin J, Jackrel ME, Hesketh CD, Carman PJ, Mack KL, Weitzman R, Gambogi C, Hernandez Murillo OA, Sweeny EA, Gurpinar E, Yokom AL, Gates SN, Yee K, Sudesh S, et al. Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity. Cell Reports. 28: 2080-2095.e6. PMID 31433984 DOI: 10.1016/J.Celrep.2019.07.069  0.827
2019 Sprunger ML, Jackrel ME. Quality Control in the ER: Misfolded Prohormones Get a Checkup. Molecular Cell. 75: 415-416. PMID 31398319 DOI: 10.1016/J.Molcel.2019.07.020  0.778
2019 Ryan JJ, Sprunger ML, Holthaus K, Shorter J, Jackrel ME. Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma. The Journal of Biological Chemistry. PMID 31171724 DOI: 10.1074/Jbc.Ra119.009494  0.832
2019 Durie CL, Lin J, Scull NW, Mack KL, Jackrel ME, Sweeny EA, Castellano LM, Shorter J, Lucius AL. Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases. Biophysical Journal. PMID 31027887 DOI: 10.1016/J.Bpj.2019.03.035  0.837
2018 Michalska K, Zhang K, March ZM, Hatzos-Skintges C, Pintilie G, Bigelow L, Castellano LM, Miles LJ, Jackrel ME, Chuang E, Jedrzejczak R, Shorter J, Chiu W, Joachimiak A. Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events. Structure (London, England : 1993). PMID 30595457 DOI: 10.1016/J.Str.2018.11.001  0.834
2018 Tariq A, Lin J, Noll MM, Torrente MP, Mack KL, Murillo OH, Jackrel ME, Shorter J. Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain. Fems Yeast Research. 18. PMID 29788207 DOI: 10.1093/Femsyr/Foy042  0.826
2018 Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, et al. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 173: 677-692.e20. PMID 29677512 DOI: 10.1016/J.Cell.2018.03.002  0.793
2018 Weaver CL, Jackrel ME, Lin J, Mack KL, Sweeny E, Duran EC, Shorter J, Lucius AL. Kinetic Mechanism of ATP-Dependent Disaggregating Motor Saccharomyces cerevisiae Hsp104 Biophysical Journal. 114: 553a. DOI: 10.1016/J.Bpj.2017.11.3021  0.78
2017 Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR. Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science (New York, N.Y.). PMID 28619716 DOI: 10.1126/Science.Aan1052  0.806
2017 Weaver CL, Duran EC, Mack KL, Lin J, Jackrel ME, Sweeny EA, Shorter J, Lucius AL. Avidity for polypeptide binding by nucleotide-bound Hsp104 structures. Biochemistry. PMID 28379007 DOI: 10.1021/Acs.Biochem.7B00225  0.81
2017 Yasuda K, Clatterbuck-Soper SF, Jackrel ME, Shorter J, Mili S. FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination. The Journal of Cell Biology. PMID 28298410 DOI: 10.1083/Jcb.201608022  0.537
2017 Jackrel ME, Shorter J. Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease. Frontiers in Neuroscience. 11: 99. PMID 28293166 DOI: 10.3389/Fnins.2017.00099  0.661
2016 Yokom AL, Gates SN, Jackrel ME, Mack KL, Su M, Shorter J, Southworth DR. Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation. Nature Structural & Molecular Biology. PMID 27478928 DOI: 10.1038/Nsmb.3277  0.837
2016 Torrente MP, Chuang E, Noll MM, Jackrel ME, Go MS, Shorter J. Mechanistic Insights Into Hsp104 Potentiation. The Journal of Biological Chemistry. PMID 26747608 DOI: 10.1074/Jbc.M115.707976  0.852
2015 Jackrel ME, Yee K, Tariq A, Chen AI, Shorter J. Disparate Mutations Confer Therapeutic Gain of Hsp104 Function. Acs Chemical Biology. PMID 26441009 DOI: 10.1021/Acschembio.5B00765  0.675
2015 Jackrel ME, Shorter J. Engineering enhanced protein disaggregases for neurodegenerative disease. Prion. 9: 90-109. PMID 25738979 DOI: 10.1080/19336896.2015.1020277  0.689
2015 Sweeny EA, Jackrel ME, Go MS, Sochor MA, Razzo BM, DeSantis ME, Gupta K, Shorter J. The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation. Molecular Cell. 57: 836-49. PMID 25620563 DOI: 10.1016/J.Molcel.2014.12.021  0.843
2014 Jackrel ME, Tariq A, Yee K, Weitzman R, Shorter J. Isolating potentiated Hsp104 variants using yeast proteinopathy models. Journal of Visualized Experiments : Jove. e52089. PMID 25407485 DOI: 10.3791/52089  0.693
2014 Jackrel ME, Shorter J. Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins. Disease Models & Mechanisms. 7: 1175-84. PMID 25062688 DOI: 10.1242/Dmm.016113  0.715
2014 Jackrel ME, Shorter J. Reversing deleterious protein aggregation with re-engineered protein disaggregases. Cell Cycle (Georgetown, Tex.). 13: 1379-83. PMID 24694655 DOI: 10.4161/Cc.28709  0.668
2014 Jackrel ME, DeSantis ME, Martinez BA, Castellano LM, Stewart RM, Caldwell KA, Caldwell GA, Shorter J. Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events. Cell. 156: 170-82. PMID 24439375 DOI: 10.1016/J.Cell.2013.11.047  0.854
2013 DeSantis ME, Leung EH, Sweeny EA, Jackrel ME, Cushman-Nick M, Neuhaus-Follini A, Vashist S, Sochor MA, Knight MN, Shorter J. Inter-Subunit Coordination in Hsp104, a Protein Disaggregase Biophysical Journal. 104: 571a. DOI: 10.1016/J.Bpj.2012.11.3173  0.802
2013 Jackrel ME, DeSantis ME, Castellano LM, Shorter J. Potentiated Hsp104 Variants Antagonize Diverse Protein Misfolding Events Biophysical Journal. 104: 570a. DOI: 10.1016/j.bpj.2012.11.3167  0.824
2012 DeSantis ME, Leung EH, Sweeny EA, Jackrel ME, Cushman-Nick M, Neuhaus-Follini A, Vashist S, Sochor MA, Knight MN, Shorter J. Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients. Cell. 151: 778-93. PMID 23141537 DOI: 10.1016/J.Cell.2012.09.038  0.809
2011 Jackrel ME, Shorter J. Shock and awe: unleashing the heat shock response to treat Huntington disease. The Journal of Clinical Investigation. 121: 2972-5. PMID 21785212 DOI: 10.1172/Jci59190  0.657
2010 Jackrel ME, Cortajarena AL, Liu TY, Regan L. Screening libraries to identify proteins with desired binding activities using a split-GFP reassembly assay. Acs Chemical Biology. 5: 553-62. PMID 20038141 DOI: 10.1021/Cb900272J  0.551
2009 Jackrel ME, Valverde R, Regan L. Redesign of a protein-peptide interaction: characterization and applications. Protein Science : a Publication of the Protein Society. 18: 762-74. PMID 19309728 DOI: 10.1002/Pro.75  0.711
2008 Champion EA, Lane BH, Jackrel ME, Regan L, Baserga SJ. A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing. Molecular and Cellular Biology. 28: 6547-56. PMID 18725399 DOI: 10.1128/Mcb.00906-08  0.55
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