Year |
Citation |
Score |
2021 |
Ten Hagen TLM, Dreher MR, Zalba S, Seynhaeve ALB, Amin M, Li L, Haemmerich D. Drug transport kinetics of intravascular triggered drug delivery systems. Communications Biology. 4: 920. PMID 34321602 DOI: 10.1038/s42003-021-02428-z |
0.327 |
|
2020 |
Gordon AC, White SB, Yang Y, Gates VL, Procissi D, Harris KR, Zhang Z, Lyu T, Huang X, Dreher MR, Omary RA, Salem R, Lewandowski RJ, Larson AC. Feasibility of Combination Intra-arterial Yttrium-90 and Irinotecan Microspheres in the VX2 Rabbit Model. Cardiovascular and Interventional Radiology. PMID 32533312 DOI: 10.1007/S00270-020-02538-X |
0.305 |
|
2019 |
Caine M, Chung T, Kilpatrick H, Bascal Z, Willis S, Tang Y, de Baere T, Dreher M, Lewis A. Evaluation of novel formulations for transarterial chemoembolization: combining elements of Lipiodol emulsions with Drug-eluting Beads. Theranostics. 9: 5626-5641. PMID 31534507 DOI: 10.7150/Thno.34778 |
0.34 |
|
2018 |
Lewis AL, Willis SL, Dreher MR, Tang Y, Ashrafi K, Wood BJ, Levy EB, Sharma KV, Negussie AH, Mikhail AS. Bench-to-clinic development of imageable drug-eluting embolization beads: finding the balance. Future Oncology (London, England). PMID 29944007 DOI: 10.2217/Fon-2018-0196 |
0.361 |
|
2017 |
Burke C, Dreher MR, Negussie AH, Mikhail AS, Yarmolenko P, Patel A, Skilskyj B, Wood BJ, Haemmerich D. Drug release kinetics of temperature sensitive liposomes measured at high-temporal resolution with a millifluidic device. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 1-9. PMID 29284329 DOI: 10.1080/02656736.2017.1412504 |
0.358 |
|
2017 |
Caine M, Carugo D, Zhang X, Hill M, Dreher MR, Lewis AL. Review of the Development of Methods for Characterization of Microspheres for Use in Embolotherapy: Translating Bench to Cathlab. Advanced Healthcare Materials. PMID 28218823 DOI: 10.1002/Adhm.201601291 |
0.364 |
|
2017 |
Ashrafi K, Tang Y, Britton H, Domenge O, Blino D, Bushby AJ, Shuturminska K, den Hartog M, Radaelli A, Negussie AH, Mikhail AS, Woods DL, Krishnasamy V, Levy EB, Wood BJ, ... ... Dreher MR, et al. Characterization of a novel intrinsically radiopaque Drug-eluting Bead for image-guided therapy: DC Bead LUMI™. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 28188808 DOI: 10.1016/J.Jconrel.2017.02.001 |
0.359 |
|
2016 |
Levy EB, Krishnasamy VP, Lewis AL, Willis S, Macfarlane C, Anderson V, van der Bom IM, Radaelli A, Dreher MR, Sharma KV, Negussie A, Mikhail AS, Geschwind JH, Wood BJ. First Human Experience with Directly Image-able Iodinated Embolization Microbeads. Cardiovascular and Interventional Radiology. PMID 27206503 DOI: 10.1007/S00270-016-1364-8 |
0.332 |
|
2016 |
Duran R, Sharma K, Dreher MR, Ashrafi K, Mirpour S, Lin M, Schernthaner RE, Schlachter TR, Tacher V, Lewis AL, Willis S, den Hartog M, Radaelli A, Negussie AH, Wood BJ, et al. A Novel Inherently Radiopaque Bead for Transarterial Embolization to Treat Liver Cancer - A Pre-clinical Study. Theranostics. 6: 28-39. PMID 26722371 DOI: 10.7150/Thno.13137 |
0.359 |
|
2016 |
Lewis AL, Dreher MR, O'Byrne V, Grey D, Caine M, Dunn A, Tang Y, Hall B, Fowers KD, Johnson CG, Sharma KV, Wood BJ. DC BeadM1™: towards an optimal transcatheter hepatic tumour therapy. Journal of Materials Science. Materials in Medicine. 27: 13. PMID 26676859 DOI: 10.1007/S10856-015-5629-6 |
0.349 |
|
2016 |
Mauxion T, Fischer A, Dreher M, Salem R. ▪ FEATURED ABSTRACTDosimetric analysis of 90Y glass and resin microsphere distributions in hepatic tumors: from the microsphere coverage to the absorbed dose Journal of Vascular and Interventional Radiology. 27: S61. DOI: 10.1016/J.Jvir.2015.12.167 |
0.349 |
|
2015 |
Tacher V, Duran R, Lin M, Sohn JH, Sharma KV, Wang Z, Chapiro J, Gacchina Johnson C, Bhagat N, Dreher MR, Schäfer D, Woods DL, Lewis AL, Tang Y, Grass M, et al. Multimodality Imaging of Ethiodized Oil-loaded Radiopaque Microspheres during Transarterial Embolization of Rabbits with VX2 Liver Tumors. Radiology. 141624. PMID 26678453 DOI: 10.1148/Radiol.2015141624 |
0.366 |
|
2015 |
Johnson CG, Tang Y, Beck A, Dreher MR, Woods DL, Negussie AH, Donahue D, Levy EB, Willis SL, Lewis AL, Wood BJ, Sharma KV. Preparation of Radiopaque Drug-Eluting Beads for Transcatheter Chemoembolization. Journal of Vascular and Interventional Radiology : Jvir. PMID 26549370 DOI: 10.1016/J.Jvir.2015.09.011 |
0.348 |
|
2015 |
Johnson CG, Sharma KV, Levy EB, Woods DL, Morris AH, Bacher JD, Lewis AL, Wood BJ, Dreher MR. Microvascular Perfusion Changes following Transarterial Hepatic Tumor Embolization. Journal of Vascular and Interventional Radiology : Jvir. PMID 26321051 DOI: 10.1016/J.Jvir.2015.06.036 |
0.421 |
|
2015 |
Levy EB, Gacchina Johnson C, Jacobs G, Woods DL, Sharma KV, Bacher JD, Lewis AL, Dreher MR, Wood BJ. Direct Quantification and Comparison of Intratumoral Hypoxia following Transcatheter Arterial Embolization of VX2 Liver Tumors with Different Diameter Microspheres. Journal of Vascular and Interventional Radiology : Jvir. PMID 26231108 DOI: 10.1016/J.Jvir.2015.06.011 |
0.354 |
|
2015 |
Negussie AH, Dreher MR, Johnson CG, Tang Y, Lewis AL, Storm G, Sharma KV, Wood BJ. Synthesis and characterization of image-able polyvinyl alcohol microspheres for image-guided chemoembolization. Journal of Materials Science. Materials in Medicine. 26: 5530. PMID 26105830 DOI: 10.1007/S10856-015-5530-3 |
0.372 |
|
2015 |
Saxena V, Gacchina Johnson C, Negussie AH, Sharma KV, Dreher MR, Wood BJ. Temperature-sensitive liposome-mediated delivery of thrombolytic agents. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 31: 67-73. PMID 25766387 DOI: 10.3109/02656736.2014.991428 |
0.395 |
|
2015 |
Duran R, Sharma K, Mirpour S, Ashrafi K, Lewis A, Reyes J, Tacher V, Willis S, Dreher M, Lin M, Geschwind J. Evaluation of novel inherently radio-opaque beads for embolotherapy of liver tumors Journal of Vascular and Interventional Radiology. 26: S79. DOI: 10.1016/J.Jvir.2014.12.220 |
0.383 |
|
2013 |
Gameiro SR, Higgins JP, Dreher MR, Woods DL, Reddy G, Wood BJ, Guha C, Hodge JW. Combination therapy with local radiofrequency ablation and systemic vaccine enhances antitumor immunity and mediates local and distal tumor regression. Plos One. 8: e70417. PMID 23894654 DOI: 10.1371/Journal.Pone.0070417 |
0.388 |
|
2013 |
Terman DS, Viglianti BL, Zennadi R, Fels D, Boruta RJ, Yuan H, Dreher MR, Grant G, Rabbani ZN, Moon E, Lan L, Eble J, Cao Y, Sorg B, Ashcraft K, et al. Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response. Plos One. 8: e52543. PMID 23326340 DOI: 10.1371/Journal.Pone.0052543 |
0.347 |
|
2013 |
Partanen A, Tillander M, Yarmolenko PS, Wood BJ, Dreher MR, Kohler MO. Reduction of peak acoustic pressure and shaping of heated region by use of multifoci sonications in MR-guided high-intensity focused ultrasound mediated mild hyperthermia. Medical Physics. 40: 013301. PMID 23298120 DOI: 10.1118/1.4769116 |
0.367 |
|
2013 |
Tacher V, Lin M, Sharma K, Gacchina C, Bhagat N, Dreher M, Lewis A, Tang Y, Wood B, Geschwind J. Visibility of radio-opaque microspheres in trans-arterial embolization of VX2 rabbit hepatic tumors Journal of Vascular and Interventional Radiology. 24: S137-S138. DOI: 10.1016/J.Jvir.2013.01.341 |
0.401 |
|
2012 |
Gasselhuber A, Dreher MR, Rattay F, Wood BJ, Haemmerich D. Comparison of conventional chemotherapy, stealth liposomes and temperature-sensitive liposomes in a mathematical model. Plos One. 7: e47453. PMID 23082168 DOI: 10.1371/Journal.Pone.0047453 |
0.471 |
|
2012 |
Manzoor AA, Lindner LH, Landon CD, Park JY, Simnick AJ, Dreher MR, Das S, Hanna G, Park W, Chilkoti A, Koning GA, ten Hagen TL, Needham D, Dewhirst MW. Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors. Cancer Research. 72: 5566-75. PMID 22952218 DOI: 10.1158/0008-5472.Can-12-1683 |
0.771 |
|
2012 |
Wang S, Shin IS, Hancock H, Jang BS, Kim HS, Lee SM, Zderic V, Frenkel V, Pastan I, Paik CH, Dreher MR. Pulsed high intensity focused ultrasound increases penetration and therapeutic efficacy of monoclonal antibodies in murine xenograft tumors. Journal of Controlled Release : Official Journal of the Controlled Release Society. 162: 218-24. PMID 22732476 DOI: 10.1016/J.Jconrel.2012.06.025 |
0.396 |
|
2012 |
Gasselhuber A, Dreher MR, Partanen A, Yarmolenko PS, Woods D, Wood BJ, Haemmerich D. Targeted drug delivery by high intensity focused ultrasound mediated hyperthermia combined with temperature-sensitive liposomes: computational modelling and preliminary in vivovalidation. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 28: 337-48. PMID 22621735 DOI: 10.3109/02656736.2012.677930 |
0.389 |
|
2012 |
Partanen A, Yarmolenko PS, Viitala A, Appanaboyina S, Haemmerich D, Ranjan A, Jacobs G, Woods D, Enholm J, Wood BJ, Dreher MR. Mild hyperthermia with magnetic resonance-guided high-intensity focused ultrasound for applications in drug delivery. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 28: 320-36. PMID 22621734 DOI: 10.3109/02656736.2012.680173 |
0.363 |
|
2012 |
Callahan DJ, Liu W, Li X, Dreher MR, Hassouneh W, Kim M, Marszalek P, Chilkoti A. Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution. Nano Letters. 12: 2165-70. PMID 22417133 DOI: 10.1021/Nl300630C |
0.755 |
|
2012 |
Lewis AL, Dreher MR. Locoregional drug delivery using image-guided intra-arterial drug eluting bead therapy. Journal of Controlled Release : Official Journal of the Controlled Release Society. 161: 338-50. PMID 22285550 DOI: 10.1016/J.Jconrel.2012.01.018 |
0.471 |
|
2012 |
Ranjan A, Jacobs GC, Woods DL, Negussie AH, Partanen A, Yarmolenko PS, Gacchina CE, Sharma KV, Frenkel V, Wood BJ, Dreher MR. Image-guided drug delivery with magnetic resonance guided high intensity focused ultrasound and temperature sensitive liposomes in a rabbit Vx2 tumor model. Journal of Controlled Release : Official Journal of the Controlled Release Society. 158: 487-94. PMID 22210162 DOI: 10.1016/J.Jconrel.2011.12.011 |
0.51 |
|
2012 |
Dreher MR, Sharma KV, Woods DL, Reddy G, Tang Y, Pritchard WF, Chiesa OA, Karanian JW, Esparza JA, Donahue D, Levy EB, Willis SL, Lewis AL, Wood BJ. Radiopaque drug-eluting beads for transcatheter embolotherapy: experimental study of drug penetration and coverage in swine. Journal of Vascular and Interventional Radiology : Jvir. 23: 257-64.e4. PMID 22178039 DOI: 10.1016/J.Jvir.2011.10.019 |
0.358 |
|
2012 |
Jang BS, Lee SM, Kim HS, Shin IS, Razjouyan F, Wang S, Yao Z, Pastan I, Dreher MR, Paik CH. Combined-modality radioimmunotherapy: synergistic effect of paclitaxel and additive effect of bevacizumab. Nuclear Medicine and Biology. 39: 472-83. PMID 22172384 DOI: 10.1016/J.Nucmedbio.2011.10.020 |
0.322 |
|
2012 |
Levy E, Jacobs G, Gacchina C, Woods D, Ranjan A, Sharma K, Bacher J, Thomas T, Lewis A, Dreher M, Wood B. Abstract No. 235: Oxygenation in hepatic VX2 tumors following transcatheter arterial embolization Journal of Vascular and Interventional Radiology. 23: S96-S97. DOI: 10.1016/J.Jvir.2011.12.286 |
0.339 |
|
2012 |
Sharma K, Gacchina C, Beck A, Woods D, Levy E, Donahue D, Tang Y, Willis S, Lewis A, Dreher M, Wood B. Abstract No. 210: Optimization of radiopaque drug eluting beads: steps toward clinical adoption and utility Journal of Vascular and Interventional Radiology. 23: S86-S87. DOI: 10.1016/J.Jvir.2011.12.259 |
0.301 |
|
2011 |
Gasselhuber A, Appanaboyina S, Dreher M, Partanen A, Wood B, Rattay F, Haemmerich D. Computational modeling of high-intensity focused ultrasound mediated drug delivery Progress in Biomedical Optics and Imaging - Proceedings of Spie. 7901. DOI: 10.1117/12.875660 |
0.42 |
|
2011 |
Dreher M, Sharma K, Woods D, Reddy G, Donahue D, Levy E, Karanian J, Chiesa O, Pritchard W, Tang Y, Willis S, Lewis A, Wood B. Abstract No. 281: Drug coverage from doxorubicin eluting radiopaque embolization beads Journal of Vascular and Interventional Radiology. 22: S119. DOI: 10.1016/J.Jvir.2011.01.309 |
0.343 |
|
2010 |
Tailor TD, Hanna G, Yarmolenko PS, Dreher MR, Betof AS, Nixon AB, Spasojevic I, Dewhirst MW. Effect of pazopanib on tumor microenvironment and liposome delivery. Molecular Cancer Therapeutics. 9: 1798-808. PMID 20515941 DOI: 10.1158/1535-7163.Mct-09-0856 |
0.458 |
|
2010 |
Gasselhuber A, Dreher MR, Negussie A, Wood BJ, Rattay F, Haemmerich D. Mathematical spatio-temporal model of drug delivery from low temperature sensitive liposomes during radiofrequency tumour ablation. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 26: 499-513. PMID 20377363 DOI: 10.3109/02656731003623590 |
0.409 |
|
2010 |
Liu W, MacKay JA, Dreher MR, Chen M, McDaniel JR, Simnick AJ, Callahan DJ, Zalutsky MR, Chilkoti A. Injectable intratumoral depot of thermally responsive polypeptide-radionuclide conjugates delays tumor progression in a mouse model. Journal of Controlled Release : Official Journal of the Controlled Release Society. 144: 2-9. PMID 20117157 DOI: 10.1016/J.Jconrel.2010.01.032 |
0.729 |
|
2010 |
Negussie AH, Miller JL, Reddy G, Drake SK, Wood BJ, Dreher MR. Synthesis and in vitro evaluation of cyclic NGR peptide targeted thermally sensitive liposome. Journal of Controlled Release : Official Journal of the Controlled Release Society. 143: 265-73. PMID 20067811 DOI: 10.1016/J.Jconrel.2009.12.031 |
0.337 |
|
2010 |
Reddy G, Sharma K, Dreher M, Woods D, Donahue D, Karanian J, Chiesa O, Pritchard W, Tang Y, Forster R, Willis S, Lewis A, Wood B. Abstract No. 192: Tissue penetration of drug from Doxorubicin eluting radiopaque embolization beads Journal of Vascular and Interventional Radiology. 21: S74. DOI: 10.1016/J.Jvir.2009.12.353 |
0.341 |
|
2009 |
Hancock H, Dreher MR, Crawford N, Pollock CB, Shih J, Wood BJ, Hunter K, Frenkel V. Evaluation of pulsed high intensity focused ultrasound exposures on metastasis in a murine model. Clinical & Experimental Metastasis. 26: 729-38. PMID 19517258 DOI: 10.1007/S10585-009-9272-9 |
0.302 |
|
2009 |
Pries AR, Cornelissen AJ, Sloot AA, Hinkeldey M, Dreher MR, Höpfner M, Dewhirst MW, Secomb TW. Structural adaptation and heterogeneity of normal and tumor microvascular networks. Plos Computational Biology. 5: e1000394. PMID 19478883 DOI: 10.1371/Journal.Pcbi.1000394 |
0.389 |
|
2009 |
Dromi SA, Walsh MP, Herby S, Traughber B, Xie J, Sharma KV, Sekhar KP, Luk A, Liewehr DJ, Dreher MR, Fry TJ, Wood BJ. Radiofrequency ablation induces antigen-presenting cell infiltration and amplification of weak tumor-induced immunity. Radiology. 251: 58-66. PMID 19251937 DOI: 10.1148/Radiol.2511072175 |
0.4 |
|
2009 |
Hardee ME, Eapen RJ, Rabbani ZN, Dreher MR, Marks J, Blackwell KL, Dewhirst MW. Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors. Cancer Chemotherapy and Pharmacology. 63: 219-28. PMID 18365198 DOI: 10.1007/S00280-008-0729-3 |
0.419 |
|
2009 |
Wood B, Poon R, Locklin J, Dreher M, Eugeni M, Ng K, Seidel G, Dromi S, Neeman Z, Kolf M, Vemuri C, Prabhakar R, Libutti S. Abstract No. 194: Phase I Study of Heat Deployed Liposomal Doxorubicin During Thermal Ablation for Hepatic Malignancies Journal of Vascular and Interventional Radiology. 20: S75. DOI: 10.1016/J.Jvir.2008.12.184 |
0.312 |
|
2008 |
Dreher MR, Simnick AJ, Fischer K, Smith RJ, Patel A, Schmidt M, Chilkoti A. Temperature triggered self-assembly of polypeptides into multivalent spherical micelles. Journal of the American Chemical Society. 130: 687-94. PMID 18085778 DOI: 10.1021/Ja0764862 |
0.74 |
|
2007 |
Dreher MR, Chilkoti A. Toward a systems engineering approach to cancer drug delivery. Journal of the National Cancer Institute. 99: 983-5. PMID 17596569 DOI: 10.1093/Jnci/Djm042 |
0.512 |
|
2007 |
Dreher MR, Liu W, Michelich CR, Dewhirst MW, Chilkoti A. Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors. Cancer Research. 67: 4418-24. PMID 17483356 DOI: 10.1158/0008-5472.Can-06-4444 |
0.655 |
|
2006 |
Liu W, Dreher MR, Furgeson DY, Peixoto KV, Yuan H, Zalutsky MR, Chilkoti A. Tumor accumulation, degradation and pharmacokinetics of elastin-like polypeptides in nude mice. Journal of Controlled Release : Official Journal of the Controlled Release Society. 116: 170-8. PMID 16919353 DOI: 10.1016/J.Jconrel.2006.06.026 |
0.785 |
|
2006 |
Liu W, Dreher MR, Chow DC, Zalutsky MR, Chilkoti A. Tracking the in vivo fate of recombinant polypeptides by isotopic labeling. Journal of Controlled Release : Official Journal of the Controlled Release Society. 114: 184-92. PMID 16904221 DOI: 10.1016/J.Jconrel.2006.06.001 |
0.495 |
|
2006 |
Chow DC, Dreher MR, Trabbic-Carlson K, Chilkoti A. Ultra-high expression of a thermally responsive recombinant fusion protein in E. coli. Biotechnology Progress. 22: 638-46. PMID 16739944 DOI: 10.1021/Bp0503742 |
0.442 |
|
2006 |
Dreher MR, Liu W, Michelich CR, Dewhirst MW, Yuan F, Chilkoti A. Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. Journal of the National Cancer Institute. 98: 335-44. PMID 16507830 DOI: 10.1093/Jnci/Djj070 |
0.616 |
|
2006 |
Furgeson DY, Dreher MR, Chilkoti A. Structural optimization of a "smart" doxorubicin-polypeptide conjugate for thermally targeted delivery to solid tumors. Journal of Controlled Release : Official Journal of the Controlled Release Society. 110: 362-9. PMID 16303202 DOI: 10.1016/J.Jconrel.2005.10.006 |
0.773 |
|
2005 |
Moeller BJ, Dreher MR, Rabbani ZN, Schroeder T, Cao Y, Li CY, Dewhirst MW. Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell. 8: 99-110. PMID 16098463 DOI: 10.1016/J.Ccr.2005.06.016 |
0.426 |
|
2005 |
Cao Y, Li CY, Moeller BJ, Yu D, Zhao Y, Dreher MR, Shan S, Dewhirst MW. Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation. Cancer Research. 65: 5498-505. PMID 15994919 DOI: 10.1158/0008-5472.Can-04-4553 |
0.388 |
|
2004 |
Dreher MR, Elas M, Ichikawa K, Barth ED, Chilkoti A, Rosen GM, Halpern HJ, Dewhirst M. Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry. Medical Physics. 31: 2755-62. PMID 15543780 DOI: 10.1118/1.1782677 |
0.517 |
|
2004 |
Dreher M, Liu W, Michelich C, Dewhirst M, Chilkoti A. 614 Increased tumor extravasation with an elastin-like polypeptide systemic thermal pump European Journal of Cancer Supplements. 2: 186. DOI: 10.1016/S1359-6349(04)80622-0 |
0.535 |
|
2003 |
Dreher MR, Raucher D, Balu N, Michael Colvin O, Ludeman SM, Chilkoti A. Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy. Journal of Controlled Release : Official Journal of the Controlled Release Society. 91: 31-43. PMID 12932635 DOI: 10.1016/S0168-3659(03)00216-5 |
0.575 |
|
2002 |
Chilkoti A, Dreher MR, Meyer DE. Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery. Advanced Drug Delivery Reviews. 54: 1093-111. PMID 12384309 DOI: 10.1016/S0169-409X(02)00060-1 |
0.624 |
|
2002 |
Chilkoti A, Dreher MR, Meyer DE, Raucher D. Targeted drug delivery by thermally responsive polymers. Advanced Drug Delivery Reviews. 54: 613-30. PMID 12204595 DOI: 10.1016/S0169-409X(02)00041-8 |
0.628 |
|
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