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Loren Looger - Publications

Affiliations: 
HHMI Janelia Farm Research Campus, Ashburn, VA, United States 
Area:
Protein Engineering
Website:
http://www.hhmi.org/research/groupleaders/looger_bio.html
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58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Aggarwal A, Liu R, Chen Y, Ralowicz AJ, Bergerson SJ, Tomaska F, Mohar B, Hanson TL, Hasseman JP, Reep D, Tsegaye G, Yao P, Ji X, Kloos M, Walpita D, ... ... Looger LL, et al. Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission. Nature Methods. PMID 37142767 DOI: 10.1038/s41592-023-01863-6  0.8
2023 Zhang Y, Rózsa M, Liang Y, Bushey D, Wei Z, Zheng J, Reep D, Broussard GJ, Tsang A, Tsegaye G, Narayan S, Obara CJ, Lim JX, Patel R, Zhang R, ... ... Looger LL, et al. Fast and sensitive GCaMP calcium indicators for imaging neural populations. Nature. PMID 36922596 DOI: 10.1038/s41586-023-05828-9  0.799
2023 Nichols AL, Blumenfeld Z, Luebbert L, Knox HJ, Muthusamy AK, Marvin JS, Kim CH, Grant SN, Walton DP, Cohen BN, Hammar R, Looger L, Artursson P, Dougherty DA, Lester HA. Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 36868853 DOI: 10.1523/JNEUROSCI.1519-22.2022  0.463
2023 Zhang Y, Looger LL. Fast and sensitive GCaMP calcium indicators for neuronal imaging. The Journal of Physiology. PMID 36811153 DOI: 10.1113/JP283832  0.345
2022 Beatty ZG, Muthusamy AK, Unger EK, Dougherty DA, Tian L, Looger LL, Shivange AV, Bera K, Lester HA, Nichols AL. Fluorescence Screens for Identifying Central Nervous System-Acting Drug-Biosensor Pairs for Subcellular and Supracellular Pharmacokinetics. Bio-Protocol. 12. PMID 36532688 DOI: 10.21769/BioProtoc.4551  0.755
2022 Nichols AL, Blumenfeld Z, Fan C, Luebbert L, Blom AEM, Cohen BN, Marvin JS, Borden PM, Kim CH, Muthusamy AK, Shivange AV, Knox HJ, Campello HR, Wang JH, Dougherty DA, ... Looger LL, et al. Correction: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands. Elife. 11. PMID 36520038 DOI: 10.7554/eLife.85479  0.761
2022 Muthusamy AK, Kim CH, Virgil SC, Knox HJ, Marvin JS, Nichols AL, Cohen BN, Dougherty DA, Looger LL, Lester HA. Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids. Journal of the American Chemical Society. PMID 35446570 DOI: 10.1021/jacs.2c02323  0.487
2022 Nichols AL, Blumenfeld Z, Fan C, Luebbert L, Blom AE, Cohen BN, Marvin JS, Borden PM, Kim CH, Muthusamy AK, Shivange AV, Knox HJ, Campello HR, Wang JH, Dougherty DA, ... Looger LL, et al. Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands. Elife. 11. PMID 34982029 DOI: 10.7554/eLife.74648  0.769
2020 Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, ... ... Looger LL, et al. Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell. PMID 33333022 DOI: 10.1016/j.cell.2020.11.040  0.747
2020 Mohr MA, Bushey D, Aggarwal A, Marvin JS, Kim JJ, Marquez EJ, Liang Y, Patel R, Macklin JJ, Lee CY, Tsang A, Tsegaye G, Ahrens AM, Chen JL, Kim DS, ... ... Looger LL, et al. jYCaMP: an optimized calcium indicator for two-photon imaging at fiber laser wavelengths. Nature Methods. PMID 32451475 DOI: 10.1038/S41592-020-0835-7  0.786
2019 Bera K, Kamajaya A, Shivange AV, Muthusamy AK, Nichols AL, Borden PM, Grant S, Jeon J, Lin E, Bishara I, Chin TM, Cohen BN, Kim CH, Unger EK, Tian L, ... ... Looger LL, et al. Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum. Frontiers in Cellular Neuroscience. 13: 499. PMID 31798415 DOI: 10.3389/Fncel.2019.00499  0.743
2019 Kazemipour A, Novak O, Flickinger D, Marvin JS, Abdelfattah AS, King J, Borden PM, Kim JJ, Al-Abdullatif SH, Deal PE, Miller EW, Schreiter ER, Druckmann S, Svoboda K, Looger LL, et al. Author Correction: Kilohertz frame-rate two-photon tomography. Nature Methods. PMID 31388143 DOI: 10.1038/S41592-019-0545-1  0.608
2019 Kazemipour A, Novak O, Flickinger D, Marvin JS, Abdelfattah AS, King J, Borden PM, Kim JJ, Al-Abdullatif SH, Deal PE, Miller EW, Schreiter ER, Druckmann S, Svoboda K, Looger LL, et al. Kilohertz frame-rate two-photon tomography. Nature Methods. 16: 778-786. PMID 31363222 DOI: 10.1038/S41592-019-0493-9  0.684
2019 Dana H, Sun Y, Mohar B, Hulse BK, Kerlin AM, Hasseman JP, Tsegaye G, Tsang A, Wong A, Patel R, Macklin JJ, Chen Y, Konnerth A, Jayaraman V, Looger LL, et al. High-performance calcium sensors for imaging activity in neuronal populations and microcompartments. Nature Methods. PMID 31209382 DOI: 10.1038/S41592-019-0435-6  0.737
2019 Shivange AV, Borden PM, Muthusamy AK, Nichols AL, Bera K, Bao H, Bishara I, Jeon J, Mulcahy MJ, Cohen B, O'Riordan SL, Kim C, Dougherty DA, Chapman ER, Marvin J, ... Looger L, et al. Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors. The Journal of General Physiology. PMID 30718376 DOI: 10.1085/Jgp.201812201  0.741
2018 Economo MN, Viswanathan S, Tasic B, Bas E, Winnubst J, Menon V, Graybuck LT, Nguyen TN, Smith KA, Yao Z, Wang L, Gerfen CR, Chandrashekar J, Zeng H, Looger LL, et al. Distinct descending motor cortex pathways and their roles in movement. Nature. 563: 79-84. PMID 30382200 DOI: 10.1038/S41586-018-0642-9  0.767
2018 Tasic B, Yao Z, Graybuck LT, Smith KA, Nguyen TN, Bertagnolli D, Goldy J, Garren E, Economo MN, Viswanathan S, Penn O, Bakken T, Menon V, Miller J, Fong O, ... ... Looger L, et al. Shared and distinct transcriptomic cell types across neocortical areas. Nature. 563: 72-78. PMID 30382198 DOI: 10.1038/S41586-018-0654-5  0.771
2018 Mizuno GO, Wang Y, Shi G, Wang Y, Sun J, Papadopoulos S, Broussard GJ, Unger EK, Deng W, Weick J, Bhattacharyya A, Chen CY, Yu G, Looger LL, Tian L. Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model. Cell Reports. 24: 355-365. PMID 29996097 DOI: 10.1016/J.Celrep.2018.06.033  0.771
2018 Muthusamy AK, Shivange AV, Nichols AL, Kamajaya A, Jeon J, Borden PM, Marvin JS, Unger EK, Bao H, Chapman ER, Tian L, Looger LL, Lester HA. Microscopy Using Fluorescent Drug Biosensors for “Inside-Out Pharmacology” Biophysical Journal. 114: 358a. DOI: 10.1016/J.Bpj.2017.11.1990  0.758
2017 Sun Y, Nern A, Franconville R, Dana H, Schreiter ER, Looger LL, Svoboda K, Kim DS, Hermundstad AM, Jayaraman V. Neural signatures of dynamic stimulus selection in Drosophila. Nature Neuroscience. PMID 28604683 DOI: 10.1038/Nn.4581  0.691
2016 Zolnik TA, Sha F, Johenning F, Schreiter ER, Looger LL, Larkum ME, Sachdev RN. All-optical functional synaptic connectivity mapping in acute brain slices using CaMPARI. The Journal of Physiology. PMID 27861906 DOI: 10.1113/Jp273116  0.634
2016 Tervo DG, Hwang BY, Viswanathan S, Gaj T, Lavzin M, Ritola KD, Lindo S, Michael S, Kuleshova E, Ojala D, Huang CC, Gerfen CR, Schiller J, Dudman JT, Hantman AW, ... Looger LL, et al. A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons. Neuron. PMID 27720486 DOI: 10.1016/J.Neuron.2016.09.021  0.779
2016 Viswanathan S, Sheikh A, Looger LL, Kanold PO. Molecularly Defined Subplate Neurons Project Both to Thalamocortical Recipient Layers and Thalamus. Cerebral Cortex (New York, N.Y. : 1991). PMID 27655928 DOI: 10.1093/Cercor/Bhw271  0.768
2016 Morisaki T, Lyon K, DeLuca KF, DeLuca JG, English BP, Zhang Z, Lavis LD, Grimm JB, Viswanathan S, Looger LL, Lionnet T, Stasevich TJ. Real-time quantification of single RNA translation dynamics in living cells. Science (New York, N.Y.). 352: 1425-9. PMID 27313040 DOI: 10.1126/Science.Aaf0899  0.76
2016 Dana H, Mohar B, Sun Y, Narayan S, Gordus A, Hasseman JP, Tsegaye G, Holt GT, Hu A, Walpita D, Patel R, Macklin JJ, Bargmann CI, Ahrens MB, Schreiter ER, ... ... Looger LL, et al. Sensitive red protein calcium indicators for imaging neural activity. Elife. 5. PMID 27011354 DOI: 10.7554/Elife.12727  0.734
2016 Morisaki T, Lyon K, DeLuca KF, DeLuca JG, English BP, Zhang Z, Lavis LD, Grimm JB, Viswanathan S, Looger LL, Lionnet T, Stasevich TJ. Real-time quantification of single RNA translation dynamics in living cells Science. 1-9. DOI: 10.1126/science.aaf0899  0.763
2015 Henderson MJ, Baldwin HA, Werley CA, Boccardo S, Whitaker LR, Yan X, Holt GT, Schreiter ER, Looger LL, Cohen AE, Kim DS, Harvey BK. A Low Affinity GCaMP3 Variant (GCaMPer) for Imaging the Endoplasmic Reticulum Calcium Store. Plos One. 10: e0139273. PMID 26451944 DOI: 10.1371/Journal.Pone.0139273  0.647
2015 Ai M, Mills H, Kanai M, Lai J, Deng J, Schreiter E, Looger L, Neubert T, Suh G. Green-to-Red Photoconversion of GCaMP. Plos One. 10: e0138127. PMID 26382605 DOI: 10.1371/Journal.Pone.0138127  0.686
2015 Viswanathan S, Williams ME, Bloss EB, Stasevich TJ, Speer CM, Nern A, Pfeiffer BD, Hooks BM, Li WP, English BP, Tian T, Henry GL, Macklin JJ, Patel R, Gerfen CR, ... ... Looger LL, et al. High-performance probes for light and electron microscopy. Nature Methods. 12: 568-76. PMID 25915120 DOI: 10.1038/Nmeth.3365  0.798
2015 Fosque BF, Sun Y, Dana H, Yang CT, Ohyama T, Tadross MR, Patel R, Zlatic M, Kim DS, Ahrens MB, Jayaraman V, Looger LL, Schreiter ER. Neural circuits. Labeling of active neural circuits in vivo with designed calcium integrators. Science (New York, N.Y.). 347: 755-60. PMID 25678659 DOI: 10.1126/Science.1260922  0.648
2015 Paez-Segala MG, Sun MG, Shtengel G, Viswanathan S, Baird MA, Macklin JJ, Patel R, Allen JR, Howe ES, Piszczek G, Hess HF, Davidson MW, Wang Y, Looger LL. Fixation-resistant photoactivatable fluorescent proteins for CLEM. Nature Methods. 12: 215-8, 4 p following. PMID 25581799 DOI: 10.1038/Nmeth.3225  0.78
2015 Hampel S, Chung P, McKellar CE, Hall D, Looger LL, Simpson JH. Erratum: Corrigendum: Drosophila Brainbow: a recombinase-based fluorescence labeling technique to subdivide neural expression patterns Nature Methods. 12: 893-893. DOI: 10.1038/Nmeth0915-893A  0.307
2015 Paez-Segala MG, Sun MG, Shtengel G, Viswanathan S, Baird MA, Macklin JJ, Patel R, Allen JR, Howe ES, Piszczek G, Hess HF, Davidson MW, Wang Y, Looger LL. Erratum: Corrigendum: Fixation-resistant photoactivatable fluorescent proteins for CLEM Nature Methods. 12: 692-692. DOI: 10.1038/Nmeth0715-692C  0.754
2015 Li W, Viswanathan S, Wang Y, Looger LL, Rivlin PK. Optimized and Improved Immunogold Labeling on Ultrathin Sections of Nervous Tissue Following High Pressure Freezing, Freeze Substitution and Low Temperature Embedding Microscopy and Microanalysis. 21: 885-886. DOI: 10.1017/S143192761500522X  0.737
2014 Dana H, Chen TW, Hu A, Shields BC, Guo C, Looger LL, Kim DS, Svoboda K. Thy1-GCaMP6 transgenic mice for neuronal population imaging in vivo. Plos One. 9: e108697. PMID 25250714 DOI: 10.1371/Journal.Pone.0108697  0.468
2013 Wardill TJ, Chen TW, Schreiter ER, Hasseman JP, Tsegaye G, Fosque BF, Behnam R, Shields BC, Ramirez M, Kimmel BE, Kerr RA, Jayaraman V, Looger LL, Svoboda K, Kim DS. A neuron-based screening platform for optimizing genetically-encoded calcium indicators. Plos One. 8: e77728. PMID 24155972 DOI: 10.1371/Journal.Pone.0077728  0.732
2013 Chen TW, Wardill TJ, Sun Y, Pulver SR, Renninger SL, Baohan A, Schreiter ER, Kerr RA, Orger MB, Jayaraman V, Looger LL, Svoboda K, Kim DS. Ultrasensitive fluorescent proteins for imaging neuronal activity. Nature. 499: 295-300. PMID 23868258 DOI: 10.1038/Nature12354  0.737
2013 Akerboom J, Carreras Calderón N, Tian L, Wabnig S, Prigge M, Tolö J, Gordus A, Orger MB, Severi KE, Macklin JJ, Patel R, Pulver SR, Wardill TJ, Fischer E, Schüler C, ... ... Looger LL, et al. Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics. Frontiers in Molecular Neuroscience. 6: 2. PMID 23459413 DOI: 10.3389/Fnmol.2013.00002  0.691
2013 Marvin JS, Borghuis BG, Tian L, Cichon J, Harnett MT, Akerboom J, Gordus A, Renninger SL, Chen TW, Bargmann CI, Orger MB, Schreiter ER, Demb JB, Gan WB, Hires SA, ... Looger LL, et al. An optimized fluorescent probe for visualizing glutamate neurotransmission. Nature Methods. 10: 162-70. PMID 23314171 DOI: 10.1038/Nmeth.2333  0.792
2013 Macklin JJ, Akerboom J, Schreiter ER, Tian L, Patel R, Mütze J, Iyer V, Karsh B, Colonell J, Harris TD, Looger LL. Two Photon Photophysics of Fluorescent Protein Calcium Indicators Biophysical Journal. 104: 682a. DOI: 10.1016/J.Bpj.2012.11.3767  0.655
2012 Chen Q, Cichon J, Wang W, Qiu L, Lee SJ, Campbell NR, Destefino N, Goard MJ, Fu Z, Yasuda R, Looger LL, Arenkiel BR, Gan WB, Feng G. Imaging neural activity using Thy1-GCaMP transgenic mice. Neuron. 76: 297-308. PMID 23083733 DOI: 10.1016/J.Neuron.2012.07.011  0.324
2012 Akerboom J, Chen TW, Wardill TJ, Tian L, Marvin JS, Mutlu S, Calderón NC, Esposti F, Borghuis BG, Sun XR, Gordus A, Orger MB, Portugues R, Engert F, Macklin JJ, ... ... Looger LL, et al. Optimization of a GCaMP calcium indicator for neural activity imaging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13819-40. PMID 23035093 DOI: 10.1523/Jneurosci.2601-12.2012  0.812
2012 Petreanu L, Gutnisky DA, Huber D, Xu NL, O'Connor DH, Tian L, Looger L, Svoboda K. Activity in motor-sensory projections reveals distributed coding in somatosensation. Nature. 489: 299-303. PMID 22922646 DOI: 10.1038/Nature11321  0.535
2012 Tian L, Hires SA, Looger LL. Imaging neuronal activity with genetically encoded calcium indicators. Cold Spring Harbor Protocols. 2012: 647-56. PMID 22661439 DOI: 10.1101/Pdb.Top069609  0.761
2012 Huber D, Gutnisky DA, Peron S, O'Connor DH, Wiegert JS, Tian L, Oertner TG, Looger LL, Svoboda K. Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature. 484: 473-8. PMID 22538608 DOI: 10.1038/nature11039  0.481
2012 Zariwala HA, Borghuis BG, Hoogland TM, Madisen L, Tian L, De Zeeuw CI, Zeng H, Looger LL, Svoboda K, Chen TW. A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3131-41. PMID 22378886 DOI: 10.1523/Jneurosci.4469-11.2012  0.56
2012 Tian L, Akerboom J, Schreiter ER, Looger LL. Neural activity imaging with genetically encoded calcium indicators. Progress in Brain Research. 196: 79-94. PMID 22341322 DOI: 10.1016/B978-0-444-59426-6.00005-7  0.765
2011 Alicea I, Marvin JS, Miklos AE, Ellington AD, Looger LL, Schreiter ER. Structure of the Escherichia coli phosphonate binding protein PhnD and rationally optimized phosphonate biosensors. Journal of Molecular Biology. 414: 356-69. PMID 22019591 DOI: 10.1016/J.Jmb.2011.09.047  0.723
2011 Marvin JS, Schreiter ER, Echevarría IM, Looger LL. A genetically encoded, high-signal-to-noise maltose sensor. Proteins. 79: 3025-36. PMID 21989929 DOI: 10.1002/Prot.23118  0.757
2011 Borghuis BG, Tian L, Xu Y, Nikonov SS, Vardi N, Zemelman BV, Looger LL. Imaging light responses of targeted neuron populations in the rodent retina. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2855-67. PMID 21414907 DOI: 10.1523/Jneurosci.6064-10.2011  0.423
2010 Del Bene F, Wyart C, Robles E, Tran A, Looger L, Scott EK, Isacoff EY, Baier H. Filtering of visual information in the tectum by an identified neural circuit. Science (New York, N.Y.). 330: 669-73. PMID 21030657 DOI: 10.1126/Science.1192949  0.316
2010 Dombeck DA, Harvey CD, Tian L, Looger LL, Tank DW. Functional imaging of hippocampal place cells at cellular resolution during virtual navigation. Nature Neuroscience. 13: 1433-40. PMID 20890294 DOI: 10.1038/Nn.2648  0.356
2009 Tian L, Hires SA, Mao T, Huber D, Chiappe ME, Chalasani SH, Petreanu L, Akerboom J, McKinney SA, Schreiter ER, Bargmann CI, Jayaraman V, Svoboda K, Looger LL. Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. Nature Methods. 6: 875-81. PMID 19898485 DOI: 10.1038/Nmeth.1398  0.812
2009 Akerboom J, Rivera JD, Guilbe MM, Malavé EC, Hernandez HH, Tian L, Hires SA, Marvin JS, Looger LL, Schreiter ER. Crystal structures of the GCaMP calcium sensor reveal the mechanism of fluorescence signal change and aid rational design. The Journal of Biological Chemistry. 284: 6455-64. PMID 19098007 DOI: 10.1074/Jbc.M807657200  0.795
2009 Tang J, Vaziri A, Akerboom JP, Looger L, Shank CV. Three dimensional super resolution fluorescence imaging of single bacterial cells by stereo photoactivated localization microscopy Microscopy and Microanalysis. 15: 564-565. DOI: 10.1017/S1431927609095737  0.351
2008 Tian L, Looger LL. Genetically encoded fluorescent sensors for studying healthy and diseased nervous systems. Drug Discovery Today. Disease Models. 5: 27-35. PMID 19461949 DOI: 10.1016/J.Ddmod.2008.07.003  0.356
2008 Hires SA, Tian L, Looger LL. Reporting neural activity with genetically encoded calcium indicators. Brain Cell Biology. 36: 69-86. PMID 18941901 DOI: 10.1007/S11068-008-9029-4  0.741
2008 Rodríguez Guilbe MM, Alfaro Malavé EC, Akerboom J, Marvin JS, Looger LL, Schreiter ER. Crystallization and preliminary X-ray characterization of the genetically encoded fluorescent calcium indicator protein GCaMP2. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 64: 629-31. PMID 18607093 DOI: 10.1107/S1744309108016059  0.753
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