Bingzhong Xue, Ph.D. - Publications

Affiliations: 
2000 The University of Tennessee, Knoxville, TN, United States 
Area:
Nutrition, Cell Biology, Molecular Biology

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Lee JH, Xue B, Chen Z, Sun Y. Neuronal GHS-R Differentially Modulates Feeding Patterns under Normal and Obesogenic Conditions. Biomolecules. 12. PMID 35204795 DOI: 10.3390/biom12020293  0.302
2022 Li F, Wang S, Cui X, Jing J, Yu L, Xue B, Shi H. Adipocyte Deficiency Promotes High-Fat Diet-Induced Metabolic Dysfunction in Mice. Cells. 11. PMID 35053297 DOI: 10.3390/cells11020181  0.359
2021 Li F, Cui X, Jing J, Wang S, Shi H, Xue B, Shi H. Brown Fat Dnmt3b Deficiency Ameliorates Obesity in Female Mice. Life (Basel, Switzerland). 11. PMID 34947856 DOI: 10.3390/life11121325  0.363
2021 Jia L, Ma Y, Haywood J, Jiang L, Xue B, Shi H, Dawson PA, Yu L. NPC1L1 Deficiency Suppresses Ileal Fibroblast Growth Factor 15 Expression and Increases Bile Acid Pool Size in High-Fat-Diet-Fed Mice. Cells. 10. PMID 34943976 DOI: 10.3390/cells10123468  0.34
2021 Li F, Jing J, Movahed M, Cui X, Cao Q, Wu R, Chen Z, Yu L, Pan Y, Shi H, Shi H, Xue B. Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat. Nature Communications. 12: 6838. PMID 34824202 DOI: 10.1038/s41467-021-27141-7  0.304
2021 Cui X, Jing J, Wu R, Cao Q, Li F, Li K, Wang S, Yu L, Schwartz G, Shi H, Xue B, Shi H. Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue. Nature Communications. 12: 5362. PMID 34508100 DOI: 10.1038/s41467-021-25766-2  0.355
2021 Wang S, Cao Q, Cui X, Jing J, Li F, Shi H, Xue B, Shi H. Deficiency in Myf5-Brown Fat Precursor Cells Promotes Obesity in Female Mice. Biomolecules. 11. PMID 34439754 DOI: 10.3390/biom11081087  0.36
2020 Wu R, Yu W, Fu L, Li F, Jing J, Cui X, Wang S, Cao Q, Xue B, Shi H. The postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice. American Journal of Physiology. Endocrinology and Metabolism. PMID 31961706 DOI: 10.1152/Ajpendo.00292.2019  0.43
2019 Wu CS, Bongmba OYN, Lee JH, Tuchaai E, Zhou Y, Li DP, Xue B, Chen Z, Sun Y. Ghrelin receptor in AgRP neurons regulates metabolic adaptation to calorie restriction. Journal of Neuroendocrinology. e12763. PMID 31251830 DOI: 10.1111/Jne.12763  0.314
2019 Cao Q, Jing J, Cui X, Shi H, Xue B. Sympathetic nerve innervation is required for beigeing in white fat. Physiological Reports. 7: e14031. PMID 30873754 DOI: 10.14814/Phy2.14031  0.43
2018 Rajan A, Shi H, Xue B. Class I and II Histone Deacetylase Inhibitors Differentially Regulate Thermogenic Gene Expression in Brown Adipocytes. Scientific Reports. 8: 13072. PMID 30166563 DOI: 10.1038/S41598-018-31560-W  0.383
2018 Schneider MK, Xue B, Shi H. Activation of the sympathetic nervous system suppresses mouse white adipose tissue hyperplasia through the β1 adrenergic receptor. Physiological Reports. 6: e13645. PMID 29611347 DOI: 10.14814/Phy2.13645  0.342
2018 Nguyen NLT, Xue B, Bartness TJ. Sensory denervation of inguinal white fat modifies sympathetic outflow to white and brown fat in Siberian hamsters. Physiology & Behavior. PMID 29447836 DOI: 10.1016/J.Physbeh.2018.02.019  0.332
2017 Bruggeman EC, Garretson JT, Wu R, Shi H, Xue B. Neuronal Dnmt1 deficiency attenuates diet-induced obesity in mice. Endocrinology. PMID 29145563 DOI: 10.1210/En.2017-00267  0.444
2017 Shin H, Ma Y, Chanturiya T, Cao Q, Wang Y, Kadegowda AKG, Jackson R, Rumore D, Xue B, Shi H, Gavrilova O, Yu L. Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice. Cell Metabolism. PMID 28988822 DOI: 10.1016/J.Cmet.2017.09.002  0.434
2017 Bruckbauer A, Banerjee J, Cao Q, Cui X, Jing J, Zha L, Li F, Xue B, Shi H, Zemel MB. Erratum: Leucine-nicotinic acid synergy stimulates AMPK/Sirt1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia and atherosclerosis in mice. American Journal of Cardiovascular Disease. 7: 97. PMID 28804683  0.552
2017 Ryu V, Zarebidaki E, Elliott Albers H, Xue B, Bartness TJ. Short photoperiod reverses obesity in Siberian hamsters via sympathetically induced lipolysis and Browning in adipose tissue. Physiology & Behavior. PMID 28694154 DOI: 10.1016/J.Physbeh.2017.07.011  0.385
2017 Bruckbauer A, Banerjee J, Cao Q, Cui X, Jing J, Zha L, Li F, Xue B, Shi H, Zemel MB. Leucine-nicotinic acid synergy stimulates AMPK/Sirt1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia and atherosclerosis in mice. American Journal of Cardiovascular Disease. 7: 33-47. PMID 28533928  0.56
2016 Bruckbauer A, Banerjee J, Fu L, Li F, Cao Q, Cui X, Wu R, Shi H, Xue B, Zemel MB. A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice. International Journal of Hepatology. 2016: 9185987. PMID 28042486 DOI: 10.1155/2016/9185987  0.599
2016 Wang X, Cao Q, Yu L, Shi H, Xue B, Shi H. Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity. Jci Insight. 1: e87748. PMID 27882346 DOI: 10.1172/Jci.Insight.87748  0.412
2016 Nguyen NL, Barr CL, Ryu V, Cao Q, Xue B, Bartness TJ. Separate and shared sympathetic outflow to white and brown fat coordinately regulate thermoregulation and beige adipocyte recruitment. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00344.2016. PMID 27881398 DOI: 10.1152/Ajpregu.00344.2016  0.322
2016 Cui X, Nguyen NL, Zarebidaki E, Cao Q, Li F, Zha L, Bartness T, Shi H, Xue B. Thermoneutrality decreases thermogenic program and promotes adiposity in high-fat diet-fed mice. Physiological Reports. 4. PMID 27230905 DOI: 10.14814/Phy2.12799  0.402
2016 Miao H, Ou J, Peng Y, Zhang X, Chen Y, Hao L, Xie G, Wang Z, Pang X, Ruan Z, Li J, Yu L, Xue B, Shi H, Shi C, et al. Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM. Nature Communications. 7: 11716. PMID 27189574 DOI: 10.1038/Ncomms11716  0.329
2016 Cao Q, Cui X, Wu R, Zha L, Wang X, Parks JS, Yu L, Shi H, Xue B. Myeloid deletion of α1AMPK exacerbates atherosclerosis in low density lipoprotein receptor knockout (LDLRKO) mice. Diabetes. PMID 26822081 DOI: 10.2337/Db15-0917  0.396
2016 Li F, Wu R, Cui X, Zha L, Yu L, Shi H, Xue B. Histone Deacetylase 1 (HDAC1) Negatively Regulates Thermogenic Program in Brown Adipocytes via Coordinated Regulation of H3K27 Deacetylation and Methylation. The Journal of Biological Chemistry. PMID 26733201 DOI: 10.1074/Jbc.M115.677930  0.395
2015 Zha L, Li F, Wu R, Artinian L, Rehder V, Yu L, Liang H, Xue B, Shi H. The Histone Demethylase UTX Promotes Brown Adipocyte Thermogenic Program Via Coordinated Regulation of H3K27 Demethylation and Acetylation. The Journal of Biological Chemistry. PMID 26306033 DOI: 10.1074/Jbc.M115.662650  0.378
2015 Fu L, Bruckbauer A, Li F, Cao Q, Cui X, Wu R, Shi H, Zemel MB, Xue B. Interaction between metformin and leucine in reducing hyperlipidemia and hepatic lipid accumulation in diet-induced obese mice. Metabolism: Clinical and Experimental. PMID 26303871 DOI: 10.1016/J.Metabol.2015.07.006  0.657
2015 Fu L, Li F, Bruckbauer A, Cao Q, Cui X, Wu R, Shi H, Xue B, Zemel MB. Interaction between leucine and phosphodiesterase 5 inhibition in modulating insulin sensitivity and lipid metabolism. Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy. 8: 227-39. PMID 25999751 DOI: 10.2147/Dmso.S82338  0.644
2015 Fu L, Bruckbauer A, Li F, Cao Q, Cui X, Wu R, Shi H, Zemel MB, Xue B. Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice. Metabolism: Clinical and Experimental. 64: 845-56. PMID 25858853 DOI: 10.1016/J.Metabol.2015.03.007  0.642
2015 Xie P, Kadegowda AK, Ma Y, Guo F, Han X, Wang M, Groban L, Xue B, Shi H, Li H, Yu L. Muscle-specific deletion of comparative gene identification-58 (CGI-58) causes muscle steatosis but improves insulin sensitivity in male mice. Endocrinology. 156: 1648-58. PMID 25751639 DOI: 10.1210/En.2014-1892  0.406
2015 Li JJ, Ferry RJ, Diao S, Xue B, Bahouth SW, Liao FF. Nedd4 haploinsufficient mice display moderate insulin resistance, enhanced lipolysis, and protection against high-fat diet-induced obesity. Endocrinology. 156: 1283-91. PMID 25607895 DOI: 10.1210/En.2014-1909  0.492
2015 Miao H, Ou J, Zhang X, Chen Y, Xue B, Shi H, Gan L, Yu L, Liang H. Macrophage CGI-58 deficiency promotes IL-1β transcription by activating the SOCS3-FOXO1 pathway. Clinical Science (London, England : 1979). 128: 493-506. PMID 25431838 DOI: 10.1042/Cs20140414  0.379
2014 Ou J, Miao H, Ma Y, Guo F, Deng J, Wei X, Zhou J, Xie G, Shi H, Xue B, Liang H, Yu L. Loss of abhd5 promotes colorectal tumor development and progression by inducing aerobic glycolysis and epithelial-mesenchymal transition. Cell Reports. 9: 1798-811. PMID 25482557 DOI: 10.1016/J.Celrep.2014.11.016  0.321
2014 Xie P, Zhu H, Jia L, Ma Y, Tang W, Wang Y, Xue B, Shi H, Yu L. Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels. Atherosclerosis. 237: 609-17. PMID 25463095 DOI: 10.1016/J.Atherosclerosis.2014.09.036  0.301
2014 Cao Q, Wang X, Jia L, Mondal AK, Diallo A, Hawkins GA, Das SK, Parks JS, Yu L, Shi H, Shi H, Xue B. Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation. Endocrinology. 155: 4925-38. PMID 25251587 DOI: 10.1210/En.2014-1595  0.358
2014 Sha H, Sun S, Francisco AB, Ehrhardt N, Xue Z, Liu L, Lawrence P, Mattijssen F, Guber RD, Panhwar MS, Brenna JT, Shi H, Xue B, Kersten S, Bensadoun A, et al. The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism. Cell Metabolism. 20: 458-70. PMID 25066055 DOI: 10.1016/J.Cmet.2014.06.015  0.42
2014 Miao H, Ou J, Ma Y, Guo F, Yang Z, Wiggins M, Liu C, Song W, Han X, Wang M, Cao Q, Chung BH, Yang D, Liang H, Xue B, et al. Macrophage CGI-58 deficiency activates ROS-inflammasome pathway to promote insulin resistance in mice. Cell Reports. 7: 223-35. PMID 24703845 DOI: 10.1016/J.Celrep.2014.02.047  0.441
2014 Yang XS, Liu MY, Zhang HM, Xue BZ, Shi H, Liu DX. Protein kinase C-δ mediates sepsis-induced activation of complement 5a and urokinase-type plasminogen activator signaling in macrophages. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 63: 581-9. PMID 24682410 DOI: 10.1007/S00011-014-0729-1  0.316
2014 Xie P, Guo F, Ma Y, Zhu H, Wang F, Xue B, Shi H, Yang J, Yu L. Intestinal Cgi-58 deficiency reduces postprandial lipid absorption. Plos One. 9: e91652. PMID 24618586 DOI: 10.1371/Journal.Pone.0091652  0.386
2014 Yang X, Wang X, Liu D, Yu L, Xue B, Shi H. Epigenetic regulation of macrophage polarization by DNA methyltransferase 3b. Molecular Endocrinology (Baltimore, Md.). 28: 565-74. PMID 24597547 DOI: 10.1210/Me.2013-1293  0.392
2013 Guo F, Ma Y, Kadegowda AK, Betters JL, Xie P, Liu G, Liu X, Miao H, Ou J, Su X, Zheng Z, Xue B, Shi H, Yu L. Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice. Journal of Lipid Research. 54: 2109-20. PMID 23733885 DOI: 10.1194/Jlr.M035519  0.356
2012 Yang Z, Wang X, He Y, Qi L, Yu L, Xue B, Shi H. The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1. Plos One. 7: e49935. PMID 23183898 DOI: 10.1371/Journal.Pone.0049935  0.462
2012 Yang Z, Hulver M, McMillan RP, Cai L, Kershaw EE, Yu L, Xue B, Shi H. Regulation of insulin and leptin signaling by muscle suppressor of cytokine signaling 3 (SOCS3). Plos One. 7: e47493. PMID 23115649 DOI: 10.1371/Journal.Pone.0047493  0.454
2012 Xue B, Yang Z, Wang X, Shi H. Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. Plos One. 7: e45990. PMID 23071533 DOI: 10.1371/Journal.Pone.0045990  0.365
2012 Delbono O, Messi ML, Wang ZM, Treves S, Mosca B, Bergamelli L, Nishi M, Takeshima H, Shi H, Xue B, Zorzato F. Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging. Experimental Gerontology. 47: 304-16. PMID 22297108 DOI: 10.1016/J.Exger.2012.01.004  0.333
2011 Wang X, Yang Z, Xue B, Shi H. Activation of the cholinergic antiinflammatory pathway ameliorates obesity-induced inflammation and insulin resistance. Endocrinology. 152: 836-46. PMID 21239433 DOI: 10.1210/En.2010-0855  0.484
2010 Brown JM, Betters JL, Lord C, Ma Y, Han X, Yang K, Alger HM, Melchior J, Sawyer J, Shah R, Wilson MD, Liu X, Graham MJ, Lee R, Crooke R, ... ... Xue B, et al. CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance. Journal of Lipid Research. 51: 3306-15. PMID 20802159 DOI: 10.1194/Jlr.M010256  0.486
2010 Yang Z, Kahn BB, Shi H, Xue BZ. Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. The Journal of Biological Chemistry. 285: 19051-9. PMID 20421294 DOI: 10.1074/Jbc.M110.123620  0.446
2010 Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Addendum: Neuronal PTP1B regulates body weight, adiposity and leptin action Nature Medicine. 16: 237-237. DOI: 10.1038/Nm0210-237B  0.304
2010 Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Erratum: Corrigendum: Neuronal PTP1B regulates body weight, adiposity and leptin action Nature Medicine. 16: 237-237. DOI: 10.1038/Nm0210-237A  0.347
2009 Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, et al. Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues. Molecular and Cellular Biology. 29: 4563-73. PMID 19528236 DOI: 10.1128/Mcb.01914-08  0.427
2009 Sutton BS, Palmer ND, Langefeld CD, Xue B, Proctor A, Ziegler JT, Haffner SM, Norris JM, Bowden DW. Association of SSTR2 polymorphisms and glucose homeostasis phenotypes: the Insulin Resistance Atherosclerosis Family Study. Diabetes. 58: 1457-62. PMID 19324939 DOI: 10.2337/Db08-0189  0.319
2009 Kennedy AR, Pissios P, Otu H, Roberson R, Xue B, Asakura K, Furukawa N, Marino FE, Liu FF, Kahn BB, Libermann TA, Maratos-Flier E. A high-fat, ketogenic diet induces a unique metabolic state in mice (American Journal of Physiology - Endocrinology and Metabolism (2007) 292, 55, (E1724-E1739)) American Journal of Physiology - Endocrinology and Metabolism. 296: E1179. DOI: 10.1152/Ajpendo.Zh1-05678-Corr-2009  0.36
2007 Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. The Journal of Biological Chemistry. 282: 23829-40. PMID 17545163 DOI: 10.1074/Jbc.M609680200  0.395
2007 Kennedy AR, Pissios P, Otu H, Roberson R, Xue B, Asakura K, Furukawa N, Marino FE, Liu FF, Kahn BB, Libermann TA, Maratos-Flier E. A high-fat, ketogenic diet induces a unique metabolic state in mice. American Journal of Physiology. Endocrinology and Metabolism. 292: E1724-39. PMID 17299079 DOI: 10.1152/Ajpendo.00717.2006  0.423
2007 Xue B, Rim JS, Hogan JC, Coulter AA, Koza RA, Kozak LP. Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. Journal of Lipid Research. 48: 41-51. PMID 17041251 DOI: 10.1194/Jlr.M600287-Jlr200  0.393
2007 Kennedy AR, Pissios P, Otu HH, Xue B, Asakura K, Furukawa N, Marino FE, Liu FF, Kahn BB, Libermann TA, Maratos-Flier E. Erratum: A high-fat, ketogenic diet induces a unique metabolic state in mice (American Journal of Physiology - Endocrinology and Metabolism doi 10.1152/ajpendo.00717.2006) American Journal of Physiology-Endocrinology and Metabolism. 293. DOI: 10.1152/Ajpendo.Zh1-5191-Corr.2007  0.383
2006 Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nature Medicine. 12: 917-24. PMID 16845389 DOI: 10.1038/Nm1435  0.453
2006 Xue B, Kahn BB. AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. The Journal of Physiology. 574: 73-83. PMID 16709629 DOI: 10.1113/Jphysiol.2006.113217  0.384
2005 Xue B, Coulter A, Rim JS, Koza RA, Kozak LP. Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots. Molecular and Cellular Biology. 25: 8311-22. PMID 16135818 DOI: 10.1128/Mcb.25.18.8311-8322.2005  0.404
2004 Rim JS, Xue B, Gawronska-Kozak B, Kozak LP. Sequestration of thermogenic transcription factors in the cytoplasm during development of brown adipose tissue. The Journal of Biological Chemistry. 279: 25916-26. PMID 15073176 DOI: 10.1074/Jbc.M402102200  0.368
2004 Minokoshi Y, Alquier T, Furukawa H, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferré P, Birnbaum MJ, Stuck BJ, Kahn BB. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus Nature. 428: 569-574. PMID 15058305 DOI: 10.1038/Nature02440  0.39
2001 Xue B, Greenberg AG, Kraemer FB, Zemel MB. Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 2527-9. PMID 11641262 DOI: 10.1096/Fj.01-0278Fje  0.559
2001 Xue B, Zemel MB. Agouti signaling protein stimulates islet amyloid polypeptide (amylin) secretion in pancreatic beta-cells. Experimental Biology and Medicine (Maywood, N.J.). 226: 565-9. PMID 11395927 DOI: 10.1177/153537020122600609  0.598
2000 Claycombe KJ, Xue BZ, Mynatt RL, Zemel MB, Moustaid-Moussa N. Regulation of leptin by agouti. Physiological Genomics. 2: 101-5. PMID 11015588 DOI: 10.1152/Physiolgenomics.2000.2.3.101  0.614
2000 Xue B, Zemel MB. Relationship between human adipose tissue agouti and fatty acid synthase (FAS). The Journal of Nutrition. 130: 2478-81. PMID 11015476 DOI: 10.1093/Jn/130.10.2478  0.612
1999 Xue BZ, Wilkison WO, Mynatt RL, Moustaid N, Goldman M, Zemel MB. The agouti gene product stimulates pancreatic [beta]-cell Ca2+ signaling and insulin release. Physiological Genomics. 1: 11-9. PMID 11015556 DOI: 10.1152/Physiolgenomics.1999.1.1.11  0.565
1998 Zemel MB, Xue B. Agouti/melanocortin interactions with leptin pathways in obesity Nutrition Reviews. 56: 271-274. PMID 9763877 DOI: 10.1111/J.1753-4887.1998.Tb01764.X  0.618
1998 Xue B, Moustaid-N, Wilkison WO, Zemel MB. The agouti gene product inhibits lipolysis in human adipocytes via a Ca2+-dependent mechanism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 12: 1391-6. PMID 9761782 DOI: 10.1096/Fasebj.12.13.1391  0.597
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