| Year |
Citation |
Score |
| 2023 |
Molinaro C, Kelly S, Tang A, Iding H, Stocker P, Linghu X, Gosselin F. Asymmetric Synthesis of -Alkyl Amino Acids through a Biocatalytic Dynamic Kinetic Resolution of PEGylated -Alkyl Amino Esters. Organic Letters. PMID 38051775 DOI: 10.1021/acs.orglett.3c03784 |
0.401 |
|
| 2021 |
Zell D, Kingston C, Jermaks J, Smith SR, Seeger N, Wassmer J, Sirois LE, Han C, Zhang H, Sigman MS, Gosselin F. Stereoconvergent and -divergent Synthesis of Tetrasubstituted Alkenes by Nickel-Catalyzed Cross-Couplings. Journal of the American Chemical Society. 143: 19078-19090. PMID 34735129 DOI: 10.1021/jacs.1c08399 |
0.317 |
|
| 2020 |
Lim N, Zhang H, Sowell CG, Gosselin F. A Fit for Purpose Synthesis of Bruton’s Tyrosine Kinase Inhibitor GDC-0852 Tetrahedron Letters. 152447. DOI: 10.1016/J.Tetlet.2020.152447 |
0.425 |
|
| 2020 |
Xu J, Carrera DE, Beaudry D, Siu M, Huestis MP, Liu W, Angelaud R, Gosselin F. Fit-for-purpose synthesis of dual leucine zipper kinase (DLK) inhibitor GNE-834 Tetrahedron Letters. 152430. DOI: 10.1016/J.Tetlet.2020.152430 |
0.414 |
|
| 2019 |
Bigler R, Mack KA, Shen J, Tosatti P, Han C, Zhang H, Scalone M, Pfaltz A, Denmark SE, Hildbrand S, Gosselin F. Asymmetric Hydrogenation of Unfunctionalized, Tetrasubstituted, Acyclic Olefins. Angewandte Chemie (International Ed. in English). PMID 31794118 DOI: 10.1002/Anie.201912640 |
0.302 |
|
| 2019 |
White NA, Clagg K, Sirois LE, Mack KA, Al-Sayah MA, Nack WA, O'Shea PD, Zhang H, Gosselin F. Phosphoramidates as Steering Elements for Highly Selective Access to Complementary Imidazo[1,2-]pyrimidine Isomers. Organic Letters. PMID 31738563 DOI: 10.1021/Acs.Orglett.9B03702 |
0.332 |
|
| 2019 |
Wong N, Petronijević F, Hong AY, Linghu X, Kelly SM, Hou H, Cravillion T, Lim NK, Robinson SJ, Han C, Molinaro C, Sowell CG, Gosselin F. Stereocontrolled Synthesis of Arylomycin-Based Gram-Negative Antibiotic GDC-5338. Organic Letters. PMID 31668077 DOI: 10.1021/Acs.Orglett.9B03481 |
0.401 |
|
| 2019 |
Xu D, Frank L, Nguyen T, Stumpf A, Russell D, Angelaud R, Gosselin F. Magnesium-Catalyzed N2-Regioselective Alkylation of 3-Substituted Pyrazoles Synlett. 31: 595-599. DOI: 10.1055/S-0039-1690160 |
0.377 |
|
| 2019 |
Stumpf A, Cheng ZK, Beaudry D, Angelaud R, Gosselin F. Improved Synthesis of the Nav1.7 Inhibitor GDC-0276 via a Highly Regioselective SNAr Reaction Organic Process Research & Development. 23: 1829-1840. DOI: 10.1021/Acs.Oprd.9B00082 |
0.442 |
|
| 2019 |
St-Jean F, Remarchuk T, Angelaud R, Carrera DE, Beaudry D, Malhotra S, McClory A, Kumar A, Ohlenbusch G, Schuster AM, Gosselin F. Manufacture of the PI3K β-Sparing Inhibitor Taselisib. Part 2: Development of a Highly Efficient and Regioselective Late-Stage Process Organic Process Research & Development. 23: 783-793. DOI: 10.1021/Acs.Oprd.9B00050 |
0.407 |
|
| 2019 |
Han C, Kelly SM, Cravillion T, Savage SJ, Nguyen T, Gosselin F. Synthesis of PI3K inhibitor GDC-0077 via a stereocontrolled N-arylation of α-amino acids Tetrahedron. 75: 4351-4357. DOI: 10.1016/J.Tet.2019.04.057 |
0.453 |
|
| 2018 |
Lim NK, Linghu X, Wong N, Zhang H, Sowell CG, Gosselin F. Macrolactamization Approaches to Arylomycin Antibiotics Core. Organic Letters. PMID 30565949 DOI: 10.1021/Acs.Orglett.8B03603 |
0.402 |
|
| 2018 |
Zhang H, Li BX, Wong B, Stumpf A, Sowell CG, Gosselin F. Convergent Synthesis of PI3K Inhibitor GDC-0908 Featuring Palladium-Catalyzed Direct C‒H Arylation toward Dihydrobenzothienooxepines. The Journal of Organic Chemistry. PMID 30543748 DOI: 10.1021/Acs.Joc.8B02751 |
0.389 |
|
| 2018 |
Savage S, McClory A, Zhang H, Cravillion T, Lim NK, Masui C, Robinson SJ, Han C, Ochs C, Rege PD, Gosselin F. Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin. The Journal of Organic Chemistry. PMID 30200756 DOI: 10.1021/Acs.Joc.8B01551 |
0.328 |
|
| 2018 |
Young IS, Glass AL, Cravillion T, Han C, Zhang H, Gosselin F. Palladium-Catalyzed Site-Selective Amidation of Dichloroazines. Organic Letters. PMID 29944383 DOI: 10.1021/Acs.Orglett.8B01483 |
0.347 |
|
| 2018 |
Lim NK, Cravillion T, Savage S, McClory A, Han C, Zhang H, DiPasquale A, Gosselin F. Synthesis of a Selective Estrogen Receptor Degrader via a Stereospecific Elimination Approach. Organic Letters. PMID 29397753 DOI: 10.1021/Acs.Orglett.8B00035 |
0.333 |
|
| 2018 |
St-Jean F, Piechowicz KA, Sirois LE, Angelaud R, Gosselin F. Study of a Competing Hydrodefluorination Reaction During the Directed ortho-Lithiation/Borylation of 2-Fluorobenzaldehyde Organometallics. 38: 119-128. DOI: 10.1021/Acs.Organomet.8B00730 |
0.382 |
|
| 2018 |
Zhang H, Cravillion T, Lim N, Tian Q, Beaudry D, Defreese JL, Fettes A, James P, Linder D, Malhotra S, Han C, Angelaud R, Gosselin F. Development of an Efficient Manufacturing Process for Reversible Bruton’s Tyrosine Kinase Inhibitor GDC-0853 Organic Process Research & Development. 22: 978-990. DOI: 10.1021/Acs.Oprd.8B00134 |
0.359 |
|
| 2018 |
Sirois LE, Xu J, Angelaud R, Lao D, Gosselin F. Practical Synthesis of a 6-Triazolylazabicyclo[3.1.0]hexane Organic Process Research & Development. 22: 728-735. DOI: 10.1021/Acs.Oprd.8B00101 |
0.371 |
|
| 2018 |
Han C, Green K, Oehring K, Meili A, Pfeifer E, Scalone M, Gosselin F. An Efficient Through-Process for Chk1 Kinase Inhibitor GDC-0575 Organic Process Research & Development. 22: 344-350. DOI: 10.1021/Acs.Oprd.7B00388 |
0.347 |
|
| 2018 |
Linghu X, Segraves NL, Abramovich I, Wong N, Müller B, Neubauer N, Fantasia S, Rieth S, Bachmann S, Jansen M, Sowell CG, Askin D, Koenig SG, Gosselin F. Cover Feature: Highly Efficient Synthesis of a Staphylococcus aureus Targeting Payload to Enable the First Antibody–Antibiotic Conjugate (Chem. Eur. J. 12/2018) Chemistry: a European Journal. 24: 2792-2792. DOI: 10.1002/Chem.201706013 |
0.325 |
|
| 2017 |
Linghu X, Segraves N, Abramovich I, Wong N, Müller B, Neubauer N, Fantasia S, Rieth S, Bachmann S, Jansen M, Sowell CG, Askin D, Koenig S, Gosselin F. Highly Efficient Synthesis of a Staphylococcus aureus-targeting Payload, Enabling the First Antibody-Antibiotic Conjugate. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29164727 DOI: 10.1002/Chem.201705392 |
0.347 |
|
| 2017 |
Lim NK, Weiss P, Li BX, McCulley CH, Hare SR, Bensema BL, Palazzo TA, Tantillo DJ, Zhang H, Gosselin F. Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins via a Syn-Elimination Approach. Organic Letters. PMID 29115843 DOI: 10.1021/Acs.Orglett.7B03141 |
0.404 |
|
| 2017 |
Han C, Savage S, Al-Sayah M, Yajima H, Remarchuk T, Reents R, Wirz B, Iding H, Bachmann S, Fantasia SM, Scalone M, Hell A, Hidber P, Gosselin F. Asymmetric Synthesis of Akt Kinase Inhibitor Ipatasertib. Organic Letters. PMID 28858516 DOI: 10.1021/Acs.Orglett.7B02228 |
0.472 |
|
| 2017 |
Mack KA, McClory A, Zhang H, Gosselin F, Collum DB. Lithium Hexamethyldisilazide-Mediated Enolization of Highly Substituted Aryl Ketones: Structural and Mechanistic Basis of the E/Z Selectivities. Journal of the American Chemical Society. PMID 28786667 DOI: 10.1021/Jacs.7B05057 |
0.316 |
|
| 2017 |
Li BX, Le DN, Mack KA, McClory A, Lim NK, Cravillion T, Savage S, Han C, Collum DB, Zhang H, Gosselin F. Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-carbon Olefins via Enol Tosylation and Suzuki‒Miyaura Coupling. Journal of the American Chemical Society. PMID 28715208 DOI: 10.1021/Jacs.7B05071 |
0.383 |
|
| 2017 |
Dalziel ME, Chen P, Carrera DE, Zhang H, Gosselin F. Highly Diastereoselective α-Arylation of Cyclic Nitriles. Organic Letters. PMID 28616988 DOI: 10.1021/Acs.Orglett.7B01421 |
0.34 |
|
| 2017 |
Kelly SM, Han C, Tung L, Gosselin F. Chemoselective Copper-Catalyzed Ullmann-Type Coupling of Oxazolidinones with Bromoiodoarenes. Organic Letters. PMID 28530104 DOI: 10.1021/Acs.Orglett.7B01304 |
0.35 |
|
| 2017 |
Linghu X, Wong N, Jost V, Fantasia S, Sowell CG, Gosselin F. Kumada–Corriu Heteroaryl Cross-Coupling for Synthesis of a Pharmaceutical Intermediate: Comparison of Batch Versus Continuous Reaction Modes Organic Process Research & Development. 21: 1320-1325. DOI: 10.1021/Acs.Oprd.7B00185 |
0.367 |
|
| 2017 |
Han C, Green K, Pfeifer E, Gosselin F. Highly Regioselective and Practical Synthesis of 5-Bromo-4-chloro-3-nitro-7-azaindole Organic Process Research & Development. 21: 664-668. DOI: 10.1021/Acs.Oprd.7B00060 |
0.387 |
|
| 2017 |
Linghu X, Wong N, Iding H, Jost V, Zhang H, Koenig SG, Sowell CG, Gosselin F. Development of a Practical Synthesis of ERK Inhibitor GDC-0994 Organic Process Research & Development. 21: 387-398. DOI: 10.1021/Acs.Oprd.7B00006 |
0.374 |
|
| 2016 |
Cheng K, McClory A, Walker W, Xu J, Zhang H, Angelaud R, Gosselin F. A Strecker approach to 2-substituted ethyl 5-aminothiazole-4-carboxylates Tetrahedron Letters. 57: 1736-1738. DOI: 10.1016/J.Tetlet.2015.12.069 |
0.394 |
|
| 2015 |
Tian Q, Hoffmann U, Humphries T, Cheng Z, Hidber P, Yajima H, Guillemot-Plass M, Li J, Bromberger U, Babu S, Askin D, Gosselin F. A practical, protecting-group-free synthesis of a PI3K/mTOR inhibitor Organic Process Research and Development. 19: 416-426. DOI: 10.1021/Op500366S |
0.425 |
|
| 2013 |
Tian Q, Cheng Z, Yajima HM, Savage SJ, Green KL, Humphries T, Reynolds ME, Babu S, Gosselin F, Askin D, Kurimoto I, Hirata N, Iwasaki M, Shimasaki Y, Miki T. A practical synthesis of a PI3K inhibitor under noncryogenic conditions via functionalization of a lithium triarylmagnesiate intermediate Organic Process Research and Development. 17: 97-107. DOI: 10.1021/Op3002992 |
0.422 |
|
| 2010 |
Gosselin F, Britton RA, Davies IW, Dolman SJ, Gauvreau D, Hoerrner RS, Hughes G, Janey J, Lau S, Molinaro C, Nadeau C, O'Shea PD, Palucki M, Sidler R. A practical synthesis of 5-lipoxygenase inhibitor MK-0633. The Journal of Organic Chemistry. 75: 4154-60. PMID 20486715 DOI: 10.1021/Jo100561U |
0.316 |
|
| 2010 |
Gosselin F, Lubell WD. ChemInform Abstract: Rigid Dipeptide Surrogates: Syntheses of Enantiopure Quinolizidinone and Pyrroloazepinone Amino Acids from a Common Diaminodicarboxylate Precursor. Cheminform. 31: no-no. DOI: 10.1002/chin.200031155 |
0.398 |
|
| 2010 |
Swarbrick ME, Gosselin F, Lubell WD. ChemInform Abstract: Alkyl Substituent Effects on Pipecolyl Amide Isomer Equilibrium: Efficient Methodology for Synthesizing Enantiopure 6-Alkylpipecolic Acids and Conformational Analysis of Their N-Acetyl N′-Methylamides. Cheminform. 30: no-no. DOI: 10.1002/chin.199932200 |
0.398 |
|
| 2010 |
Gosselin F, Lubell WD. ChemInform Abstract: An Olefination Entry for the Synthesis of Enantiopure α,ω-Diaminodicarboxylates and Azabicyclo[X.Y.0]alkane Amino Acids. Cheminform. 30: no-no. DOI: 10.1002/chin.199913225 |
0.325 |
|
| 2009 |
O'Shea PD, Gauvreau D, Gosselin F, Hughes G, Nadeau C, Roy A, Shultz CS. Practical synthesis of a potent bradykinin B(1) antagonist via enantioselective hydrogenation of a pyridyl N-acyl enamide. The Journal of Organic Chemistry. 74: 4547-53. PMID 19456171 DOI: 10.1021/jo802772d |
0.338 |
|
| 2007 |
Gosselin F, O'Shea PD, Webster RA, Reamer RA, Tillyer RD, Grabowski EJJ. Highly Regioselective Synthesis of 1-Aryl-3,4,5-Substituted Pyrazoles. Cheminform. 38. DOI: 10.1002/chin.200715113 |
0.346 |
|
| 2006 |
Dolman SJ, Gosselin F, O'Shea PD, Davies IW. Superior reactivity of thiosemicarbazides in the synthesis of 2-amino-1,3,4-oxadiazoles. The Journal of Organic Chemistry. 71: 9548-51. PMID 17137395 DOI: 10.1021/jo0618730 |
0.426 |
|
| 2006 |
Wender PA, Bi FC, Buschmann N, Gosselin F, Kan C, Kee JM, Ohmura H. Studies on oxidopyrylium [5+2] cycloadditions: toward a general synthetic route to the C12-hydroxydaphnetoxins. Organic Letters. 8: 5373-6. PMID 17078721 DOI: 10.1021/Ol062234E |
0.346 |
|
| 2006 |
Roy A, Gosselin F, O'Shea PD, Chen CY. Diastereoselective arylithium addition to an alpha-trifluoromethyl imine. Practical synthesis of a potent cathepsin K inhibitor. The Journal of Organic Chemistry. 71: 4320-3. PMID 16709080 DOI: 10.1021/jo052430j |
0.321 |
|
| 2006 |
Gosselin F, O'Shea PD, Webster RA, Reamer RA, Tillyer RD, Grabowski EJJ. Highly regioselective synthesis of 1-aryl-3,4,5-substituted pyrazoles Synlett. 3267-3270. DOI: 10.1055/s-2006-956487 |
0.346 |
|
| 2006 |
Nadeau C, Gosselin F, O’Shea PD, Davies IW, Volante RP. Enantioselective Synthesis of (S)-γ-Fluoroleucine Ethyl Ester Synfacts. 2006: 363-363. DOI: 10.1055/S-2006-932052 |
0.399 |
|
| 2004 |
Gosselin F, Roy A, O'Shea PD, Chen CY, Volante RP. Oxazolidine ring opening and isomerization to (E)-imines. Asymmetric synthesis of aryl-alpha-fluoroalkyl amino alcohols. Organic Letters. 6: 641-4. PMID 14961643 DOI: 10.1021/ol036486g |
0.308 |
|
| 2002 |
Wender PA, Bi FC, Gamber GG, Gosselin F, Hubbard RD, Scanio MJC, Sun R, Williams TJ, Zhang L. Toward the ideal synthesis. New transition metal-catalyzed reactions inspired by novel medicinal leads Pure and Applied Chemistry. 74: 25-31. DOI: 10.1351/Pac200274010025 |
0.327 |
|
| 2001 |
Gosselin F, Tourwé D, Ceusters M, Meert T, Heylen L, Jurzak M, Lubell WD. Probing opioid receptor-ligand interactions by employment of indolizidin-9-one amino acid as a constrained Gly(2)-Gly(3) surrogate in a leucine-enkephalin mimic. The Journal of Peptide Research : Official Journal of the American Peptide Society. 57: 337-44. PMID 11328491 DOI: 10.1046/J.1397-002X.2000.00812.X |
0.583 |
|
| 2001 |
Halab L, Gosselin F, Lubell WD. ChemInform Abstract: Design, Synthesis, and Conformational Analysis of Azacycloalkane Amino Acids as Conformationally Constrained Probes for Mimicry of Peptide Secondary Structures Cheminform. 32: no-no. DOI: 10.1002/chin.200119258 |
0.709 |
|
| 2000 |
Halab L, Gosselin F, Lubell WD. Design, synthesis, and conformational analysis of azacycloalkane amino acids as conformationally constrained probes for mimicry of peptide secondary structures. Biopolymers. 55: 101-22. PMID 11074409 DOI: 10.1002/1097-0282(2000)55:2<101::Aid-Bip20>3.0.Co;2-O |
0.672 |
|
| 2000 |
Gosselin F, Lubell WD. Rigid dipeptide surrogates: syntheses of enantiopure quinolizidinone and pyrroloazepinone amino acids from a common diaminodicarboxylate precursor. The Journal of Organic Chemistry. 65: 2163-71. PMID 10774041 DOI: 10.1021/Jo991766O |
0.676 |
|
| 1999 |
Swarbrick ME, Gosselin F, Lubell WD. Alkyl Substituent Effects on Pipecolyl Amide Isomer Equilibrium: Efficient Methodology for Synthesizing Enantiopure 6-Alkylpipecolic Acids and Conformational Analysis of Their N-Acetyl N'-Methylamides. The Journal of Organic Chemistry. 64: 1993-2002. PMID 11674294 DOI: 10.1021/Jo982181H |
0.553 |
|
| 1999 |
Gosselin F, Van Betsbrugge J, Hatam M, Lubell WD. A Novel Linking-Protecting Group Strategy for Solid-Phase Organic Chemistry with Configurationally Stable α-[N-(Phenylfluorenyl)]amino Carbonyl Compounds: Synthesis of Enantiopure Norephedrines on Solid Support The Journal of Organic Chemistry. 64: 2486-2493. DOI: 10.1021/Jo982413C |
0.56 |
|
| 1998 |
Gosselin F, Lubell WD. An Olefination Entry for the Synthesis of Enantiopure alpha,omega-Diaminodicarboxylates and Azabicyclo[X.Y.0]alkane Amino Acids. The Journal of Organic Chemistry. 63: 7463-7471. PMID 11672399 DOI: 10.1021/Jo9814602 |
0.634 |
|
| 1996 |
Gosselin F, Di Renzo M, Ellis TH, Lubell WD. Photoacoustic FTIR Spectroscopy, a Nondestructive Method for Sensitive Analysis of Solid-Phase Organic Chemistry. The Journal of Organic Chemistry. 61: 7980-7981. PMID 11667768 DOI: 10.1021/Jo961393G |
0.424 |
|
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