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Youcai Zhang, Ph.D. - Publications

Affiliations: 
2011 Pharmacology, Toxicology & Therapeutics University of Kansas, Lawrence, KS, United States 
Area:
Toxicology
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51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Yu X, Zhang Y, Cogliati B, Klaassen CD, Kumar S, Cheng X, Bu P. Distinct bile acid alterations in response to a single administration of PFOA and PFDA in mice. Toxicology. 153719. PMID 38181850 DOI: 10.1016/j.tox.2023.153719  0.823
2022 Bi Y, Wang X, Han L, Tian Y, Bo T, Li C, Shi B, Gui C, Zhang Y. Selective Inhibition of Organic Cation Transporter 1 by Benzoylpaeoniflorin Attenuates Hepatic Lipid Accumulation through AMPK Activation. Journal of Natural Products. PMID 36563333 DOI: 10.1021/acs.jnatprod.2c00927  0.361
2021 Xiong H, Zhang C, Han L, Xu T, Saeed K, Han J, Liu J, Klaassen CD, Gonzalez FJ, Lu Y, Zhang Y. Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity. Hepatology (Baltimore, Md.). PMID 34870866 DOI: 10.1002/hep.32270  0.44
2021 Liu J, Yu H, Fan Y, Xu T, Zhang C, Zhou L, Li G, Zhang Y. Allopurinol protects against cholestatic liver injury in mice not through depletion of uric acid. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 33749747 DOI: 10.1093/toxsci/kfab034  0.51
2021 Liu J, Lickteig AJ, Zhang Y, Csanaky IL, Klaassen CD. Activation of Nrf2 decreases bile acid concentrations in livers of female mice. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-11. PMID 33522359 DOI: 10.1080/00498254.2021.1880033  0.694
2020 Zhang Y, Lickteig AJ, Liu J, Csanaky IL, Klaassen CD. Effects of ablation and activation of Nrf2 on bile acid homeostasis in mice. Toxicology and Applied Pharmacology. 115170. PMID 32738332 DOI: 10.1016/J.Taap.2020.115170  0.682
2020 Csanaky IL, Lickteig AJ, Zhang Y, Klaassen CD. Effects of the patent ductus venosus on bile acid homeostasis in aryl hydrocarbon receptor (AhR)-null mice. Toxicology and Applied Pharmacology. 115136. PMID 32679164 DOI: 10.1016/J.Taap.2020.115136  0.729
2020 Li G, Xiong H, Saeed K, Ma R, Xing Y, Bi Y, Li C, Huang J, Zhang Y. Comparative toxicity analysis of corannulene and benzo[a]pyrene in mice. Toxicology Letters. PMID 32417428 DOI: 10.1016/j.toxlet.2020.05.002  0.467
2019 Li G, Han L, Ma R, Saeed K, Xiong H, Klaassen C, Lu Y, Zhang Y. Glucocorticoids increase renal excretion of urate in mice by down-regulating urate transporter 1. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31519697 DOI: 10.1124/dmd.119.087700  0.626
2019 Lickteig AJ, Zhang Y, Klaassen CD, Csanaky IL. Effects of Absence of Constitutive Androstane Receptor (CAR) on Bile Acid Homeostasis in Male and Female Mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31225615 DOI: 10.1093/Toxsci/Kfz143  0.726
2018 Wei J, Chen J, Fu L, Han L, Gao X, Sarhene M, Hu L, Zhang Y, Fan G. Polygonum multiflorum Thunb suppress bile acid synthesis by activating Fxr-Fgf15 signaling in the intestine. Journal of Ethnopharmacology. PMID 30528660 DOI: 10.1016/j.jep.2018.12.007  0.498
2018 Wang X, Han L, Bi Y, Li C, Gao X, Fan G, Zhang Y. Paradoxical effects of emodin on ANIT-induced intrahepatic cholestasis and herb-induced hepatotoxicity in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30517764 DOI: 10.1093/toxsci/kfy295  0.564
2018 Wang X, Wang F, Lu Z, Jin X, Zhang Y. Semi-quantitative profiling of bile acids in serum and liver reveals the dosage-related effects of dexamethasone on bile acid metabolism in mice. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1095: 65-74. PMID 30055378 DOI: 10.1016/j.jchromb.2018.07.021  0.476
2018 Wang X, Wang F, Zhang Y, Xiong H, Zhang Y, Zhuang P, Zhang Y. Diabetic cognitive dysfunction is associated with increased bile acids in liver and activation of bile acid signaling in intestine. Toxicology Letters. PMID 29382564 DOI: 10.1016/j.toxlet.2018.01.006  0.583
2018 Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD. Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion. Toxicology and Applied Pharmacology. 338: 112-123. PMID 29175453 DOI: 10.1016/J.Taap.2017.11.014  0.665
2017 Wang F, Lu Z, Wang X, Zhang Y. Impaired vagus function in rats suppresses bile acid synthesis in the liver by disrupting tight junctions and activating Fxr-Fgf15 signaling in the intestine. Biochemical and Biophysical Research Communications. PMID 29198707 DOI: 10.1016/j.bbrc.2017.11.201  0.455
2017 Zhang Y, Zhang Y, Klaassen CD, Cheng X. Alteration of bile acid and cholesterol biosynthesis and transport by perfluorononanoic acid (PFNA) in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29112762 DOI: 10.1093/Toxsci/Kfx237  0.826
2017 Wang X, Han L, Li G, Peng W, Gao X, Klaassen CD, Fan G, Zhang Y. Identification of natural products as inhibitors of human organic anion transporters (OAT1 and OAT3) and their protective effect on mercury-induced toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29045746 DOI: 10.1093/Toxsci/Kfx216  0.364
2017 Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD. Clofibrate decreases bile acids in livers of male mice by increasing biliary bile acid excretion in a PPARα-dependent manner. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28973556 DOI: 10.1093/Toxsci/Kfx191  0.716
2017 Bu P, Le Y, Zhang Y, Zhang Y, Cheng X. Berberine-induced Inactivation of Signal Transducer and Activator of Transcription 5 Signaling Promotes Male-specific Expression of a Bile-acid Uptake Transporter. The Journal of Biological Chemistry. PMID 28154180 DOI: 10.1074/Jbc.M116.757567  0.726
2016 Guo Y, Zhang Y, Huang W, Selwyn FP, Klaassen CD. Dose-response effect of berberine on bile acid profile and gut microbiota in mice. Bmc Complementary and Alternative Medicine. 16: 394. PMID 27756364 DOI: 10.1186/S12906-016-1367-7  0.548
2015 Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM. Prediction and validation of enzyme and transporter off-targets for metformin. Journal of Pharmacokinetics and Pharmacodynamics. PMID 26335661 DOI: 10.1007/S10928-015-9436-Y  0.308
2015 Selwyn FP, Csanaky IL, Zhang Y, Klaassen CD. Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 1544-56. PMID 26199423 DOI: 10.1124/Dmd.115.065276  0.714
2014 Cheng X, Zhang Y, Klaassen CD. Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum. The Journal of Pharmacology and Experimental Therapeutics. 351: 105-13. PMID 25034404 DOI: 10.1124/Jpet.114.216796  0.812
2014 Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, et al. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proceedings of the National Academy of Sciences of the United States of America. 111: 9983-8. PMID 24961373 DOI: 10.1073/Pnas.1314939111  0.588
2014 Zhang Y, Limaye PB, Renaud HJ, Klaassen CD. Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice. Toxicology and Applied Pharmacology. 277: 138-45. PMID 24657338 DOI: 10.1016/J.Taap.2014.03.009  0.607
2013 Chen X, Ying X, Zhang W, Chen Y, Shi C, Hou Y, Zhang Y. The hepatoprotective effect of fraxetin on carbon tetrachloride induced hepatic fibrosis by antioxidative activities in rats. International Immunopharmacology. 17: 543-7. PMID 23994349 DOI: 10.1016/j.intimp.2013.08.006  0.326
2013 Liu J, Lu YF, Zhang Y, Wu KC, Fan F, Klaassen CD. Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice. Toxicology and Applied Pharmacology. 272: 816-24. PMID 23948738 DOI: 10.1016/J.Taap.2013.08.003  0.704
2013 Zhang Y, Csanaky IL, Selwyn FP, Lehman-McKeeman LD, Klaassen CD. Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism. Biochemical Pharmacology. 86: 437-45. PMID 23747753 DOI: 10.1016/J.Bcp.2013.05.020  0.743
2013 Zhang Y, Klaassen CD. Hormonal regulation of Cyp4a isoforms in mouse liver and kidney. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 43: 1055-63. PMID 23725209 DOI: 10.3109/00498254.2013.797622  0.627
2013 Zhang YK, Wu KC, Klaassen CD. Genetic activation of Nrf2 protects against fasting-induced oxidative stress in livers of mice. Plos One. 8: e59122. PMID 23527105 DOI: 10.1371/Journal.Pone.0059122  0.651
2013 Zhang YK, Lu H, Klaassen CD. Expression of human CAR splicing variants in BAC-transgenic mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 132: 142-50. PMID 23152187 DOI: 10.1093/Toxsci/Kfs321  0.664
2012 Zhang YK, Wu KC, Liu J, Klaassen CD. Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet. Toxicology and Applied Pharmacology. 264: 305-14. PMID 23017736 DOI: 10.1016/J.Taap.2012.09.014  0.614
2012 Wu KC, Zhang Y, Klaassen CD. Nrf2 protects against diquat-induced liver and lung injury. Free Radical Research. 46: 1220-9. PMID 22762311 DOI: 10.3109/10715762.2012.700709  0.671
2012 Zhang Y, Limaye PB, Lehman-McKeeman LD, Klaassen CD. Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice. Plos One. 7: e34522. PMID 22496825 DOI: 10.1371/Journal.Pone.0034522  0.705
2012 Kong B, Wang L, Chiang JY, Zhang Y, Klaassen CD, Guo GL. Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology (Baltimore, Md.). 56: 1034-43. PMID 22467244 DOI: 10.1002/Hep.25740  0.651
2012 Zhang Y, Csanaky IL, Cheng X, Lehman-McKeeman LD, Klaassen CD. Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 127: 451-62. PMID 22461449 DOI: 10.1093/Toxsci/Kfs123  0.815
2012 Zhang Y, Cheng X, Aleksunes L, Klaassen CD. Transcription factor-mediated regulation of carboxylesterase enzymes in livers of mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1191-7. PMID 22429928 DOI: 10.1124/Dmd.111.043877  0.775
2012 Li T, Francl JM, Boehme S, Ochoa A, Zhang Y, Klaassen CD, Erickson SK, Chiang JY. Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity. The Journal of Biological Chemistry. 287: 1861-73. PMID 22144677 DOI: 10.1074/Jbc.M111.305789  0.628
2012 Zhang Y, Hong JY, Rockwell CE, Copple BL, Jaeschke H, Klaassen CD. Effect of bile duct ligation on bile acid composition in mouse serum and liver. Liver International : Official Journal of the International Association For the Study of the Liver. 32: 58-69. PMID 22098667 DOI: 10.1111/J.1478-3231.2011.02662.X  0.642
2011 Zhang Y, Csanaky IL, Lehman-McKeeman LD, Klaassen CD. Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability. Toxicological Sciences : An Official Journal of the Society of Toxicology. 124: 251-60. PMID 21914718 DOI: 10.1093/Toxsci/Kfr236  0.713
2011 Song P, Zhang Y, Klaassen CD. Dose-response of five bile acids on serum and liver bile Acid concentrations and hepatotoxicty in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 123: 359-67. PMID 21747115 DOI: 10.1093/Toxsci/Kfr177  0.728
2011 Gong L, Aranibar N, Han YH, Zhang Y, Lecureux L, Bhaskaran V, Khandelwal P, Klaassen CD, Lehman-McKeeman LD. Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles Toxicological Sciences. 122: 587-597. PMID 21561886 DOI: 10.1093/Toxsci/Kfr114  0.681
2011 Zhang YK, Guo GL, Klaassen CD. Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters. Plos One. 6: e16683. PMID 21346810 DOI: 10.1371/Journal.Pone.0016683  0.535
2011 Csanaky IL, Lu H, Zhang Y, Ogura K, Choudhuri S, Klaassen CD. Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice. Hepatology (Baltimore, Md.). 53: 272-81. PMID 20949553 DOI: 10.1002/Hep.23984  0.749
2010 Zhang Y, Klaassen CD. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. Journal of Lipid Research. 51: 3230-42. PMID 20671298 DOI: 10.1194/Jlr.M007641  0.678
2010 Zhang YK, Saupe KW, Klaassen CD. Energy restriction does not compensate for the reduced expression of hepatic drug-processing genes in mice with aging. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 1122-31. PMID 20382754 DOI: 10.1124/Dmd.110.032599  0.585
2010 Zhang YK, Yeager RL, Tanaka Y, Klaassen CD. Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. Toxicology and Applied Pharmacology. 245: 326-34. PMID 20350562 DOI: 10.1016/J.Taap.2010.03.016  0.679
2009 Yang X, Zhang YK, Esterly N, Klaassen CD, Wan YJ. Gender disparity of hepatic lipid homoeostasis regulated by the circadian clock. Journal of Biochemistry. 145: 609-23. PMID 19174548 DOI: 10.1093/Jb/Mvp018  0.5
2009 Zhang YK, Yeager RL, Klaassen CD. Circadian expression profiles of drug-processing genes and transcription factors in mouse liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 106-15. PMID 18838502 DOI: 10.1124/Dmd.108.024174  0.538
2008 Merrell MD, Jackson JP, Augustine LM, Fisher CD, Slitt AL, Maher JM, Huang W, Moore DD, Zhang Y, Klaassen CD, Cherrington NJ. The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1716-21. PMID 18474683 DOI: 10.1124/Dmd.108.020867  0.778
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