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Nigel Mackman - Publications

Affiliations: 
Pathology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pathology, Molecular Biology
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338 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Sachetto ATA, Mackman N. Evaluation of the ability of commercial enzyme-linked immunosorbent assays to measure mouse tissue factor. Research and Practice in Thrombosis and Haemostasis. 8: 102325. PMID 38404939 DOI: 10.1016/j.rpth.2024.102325  0.306
2023 Sachetto ATA, Mackman N. Monocyte tissue factor expression: LPS induction and roles in pathological activation of coagulation. Thrombosis and Haemostasis. PMID 37168007 DOI: 10.1055/a-2091-7006  0.354
2021 Zhang Y, Cui J, Zhang G, Wu C, Abdel-Latif A, Smyth SS, Shiroishi T, Mackman N, Wei Y, Tao M, Li Z. Inflammasome activation promotes venous thrombosis through pyroptosis. Blood Advances. 5: 2619-2623. PMID 34152402 DOI: 10.1182/bloodadvances.2020003041  0.305
2021 Tawil N, Bassawon R, Meehan B, Nehme A, Montermini L, Gayden T, De Jay N, Spinelli C, Chennakrishnaiah S, Choi D, Adnani L, Zeinieh M, Jabado N, Kleinman CL, Witcher M, ... ... Mackman N, et al. Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles. Blood Advances. 5: 1682-1694. PMID 33720339 DOI: 10.1182/bloodadvances.2020002998  0.328
2020 Grover SP, Olson TM, Cooley BC, Mackman N. Model-dependent contributions of FXII and FXI to venous thrombosis in mice. Journal of Thrombosis and Haemostasis : Jth. PMID 33094904 DOI: 10.1111/Jth.15037  0.324
2020 Grover SP, Mackman N. Tissue factor in atherosclerosis and atherothrombosis. Atherosclerosis. 307: 80-86. PMID 32674807 DOI: 10.1016/J.Atherosclerosis.2020.06.003  0.428
2020 Mackman N, Antoniak S, Wolberg AS, Kasthuri R, Key NS. Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120314514. PMID 32657623 DOI: 10.1161/Atvbaha.120.314514  0.321
2020 d'Alessandro E, Becker C, Bergmeier W, Bode C, Bourne JH, Brown H, Buller HR, Ten Cate-Hoek AJ, Ten Cate V, van Cauteren YJM, Cheung YFH, Cleuren A, Coenen D, Crijns HJGM, de Simone I, ... ... Mackman N, et al. Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis. Thrombosis and Haemostasis. 120: 538-564. PMID 32289858 DOI: 10.1055/S-0040-1708035  0.327
2020 Greenberg AR, Huber BR, Liu DX, Logue JP, Woolsey Hischak AM, Hart RJ, Abbott M, Isic N, Hisada YM, Mackman N, Bennett RS, Hensley LE, Connor JH, Crossland NA. Quantification of Viral and Host Biomarkers in the Liver of Rhesus Macaques: a Longitudinal Study of Zaire Ebolavirus strain Kikwit (EBOV/Kik). The American Journal of Pathology. PMID 32275904 DOI: 10.1016/J.Ajpath.2020.03.003  0.305
2020 Grover SP, Schmedes CM, Auriemma AC, Butler E, Parrish ML, Miszta A, Cleuren AC, Visser M, Heitmeier S, Posma JJ, Spronk HM, Antoniak S, Wolberg AS, Pawlinski R, Gailani D, ... Mackman N, et al. Differential roles of factors IX and XI in murine placenta and hemostasis under conditions of low tissue factor. Blood Advances. 4: 207-216. PMID 31935292 DOI: 10.1182/Bloodadvances.2019000921  0.416
2020 Visser M, Oerle Rv, Cate Ht, Laux V, Mackman N, Heitmeier S, Spronk HMH. Plasma Kallikrein Contributes to Coagulation in the Absence of Factor XI by Activating Factor IX Arteriosclerosis, Thrombosis, and Vascular Biology. 40: 103-111. PMID 31766871 DOI: 10.1161/Atvbaha.119.313503  0.367
2020 Schmedes CM, Grover SP, Hisada YM, Goeijenbier M, Hultdin J, Nilsson S, Thunberg T, Ahlm C, Mackman N, Connolly AF. Circulating Extracellular Vesicle Tissue Factor Activity During Orthohantavirus Infection Is Associated With Intravascular Coagulation. The Journal of Infectious Diseases. 222: 1392-1399. PMID 31722433 DOI: 10.1093/Infdis/Jiz597  0.392
2019 Yang X, Cheng X, Tang Y, Qiu X, Wang Y, Kang H, Wu J, Wang Z, Liu Y, Chen F, Xiao X, Mackman N, Billiar TR, Han J, Lu B. Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure. Immunity. PMID 31836429 DOI: 10.1016/J.Immuni.2019.11.005  0.35
2019 Hisada Y, Mackman N. Update from the laboratory: mechanistic studies of pathways of cancer-associated venous thrombosis using mouse models. Hematology. 2019: 182-186. PMID 31808871 DOI: 10.1182/Hematology.2019000025  0.357
2019 Boucher AA, Rosenfeldt L, Mureb D, Shafer J, Sharma BK, Lane A, Crowther RR, McKell MC, Whitt J, Alenghat T, Qualls J, Antoniak S, Mackman N, Flick MJ, Steinbrecher KA, et al. Cell type-specific mechanisms coupling protease-activated receptor-1 to infectious colitis pathogenesis. Journal of Thrombosis and Haemostasis : Jth. PMID 31539206 DOI: 10.1111/Jth.14641  0.311
2019 Vallier L, Bouriche T, Bonifay A, Judicone C, Bez J, Franco C, Guervilly C, Hisada Y, Mackman N, Houston R, Poncelet P, Dignat-George F, Lacroix R. Increasing the sensitivity of the human microvesicle tissue factor activity assay. Thrombosis Research. 182: 64-74. PMID 31450010 DOI: 10.1016/J.Thromres.2019.07.011  0.384
2019 Maqsood A, Hisada Y, Garratt KB, Homeister J, Mackman N. Rivaroxaban does not affect growth of human pancreatic tumors in mice. Journal of Thrombosis and Haemostasis. 17: 2169-2173. PMID 31393055 DOI: 10.1111/Jth.14604  0.342
2019 Tatsumi K, Schmedes CM, Houston ER, Butler E, Mackman N, Antoniak S. Protease-activated receptor 4 protects mice from Coxsackievirus B3 and H1N1 influenza A virus infection. Cellular Immunology. 103949. PMID 31337508 DOI: 10.1016/J.Cellimm.2019.103949  0.334
2019 Thålin C, Hisada Y, Lundström S, Mackman N, Wallén H. Neutrophil Extracellular Traps: Villains and Targets in Arterial, Venous, and Cancer-Associated Thrombosis Arteriosclerosis, Thrombosis, and Vascular Biology. 39: 1724-1738. PMID 31315434 DOI: 10.1161/Atvbaha.119.312463  0.394
2019 Hisada Y, Mackman N. Cancer cell-derived tissue factor-positive extracellular vesicles: biomarkers of thrombosis and survival. Current Opinion in Hematology. 26: 349-356. PMID 31261175 DOI: 10.1097/Moh.0000000000000521  0.351
2019 Nieuwland R, Gardiner C, Dignat‐George F, Mullier F, Mackman N, Woodhams B, Thaler J. Toward standardization of assays measuring extracellular vesicle-associated tissue factor activity. Journal of Thrombosis and Haemostasis. 17: 1261-1264. PMID 31231949 DOI: 10.1111/Jth.14481  0.38
2019 Puhm F, Afonyushkin T, Resch U, Obermayer G, Rohde M, Penz T, Schuster M, Wagner G, Rendeiro AF, Melki I, Kaun C, Wojta J, Bock C, Jilma B, Mackman N, et al. Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells. Circulation Research. 125: 43-52. PMID 31219742 DOI: 10.1161/Circresaha.118.314601  0.345
2019 Hisada Y, Mackman N. Tissue Factor and Cancer: Regulation, Tumor Growth, and Metastasis. Seminars in Thrombosis and Hemostasis. PMID 31096306 DOI: 10.1055/S-0039-1687894  0.389
2019 Wu C, Lu W, Zhang Y, Zhang G, Shi X, Hisada Y, Grover SP, Zhang X, Li L, Xiang B, Shi J, Li XA, Daugherty A, Smyth SS, Kirchhofer D, ... ... Mackman N, et al. Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis. Immunity. PMID 31076358 DOI: 10.1016/J.Immuni.2019.04.003  0.373
2019 Tatsumi K, Hisada Y, Connolly AF, Buranda T, Mackman N. Patients with severe orthohantavirus cardiopulmonary syndrome due to Sin Nombre Virus infection have increased circulating extracellular vesicle tissue factor and an activated coagulation system. Thrombosis Research. 179: 31-33. PMID 31075699 DOI: 10.1016/J.Thromres.2019.04.032  0.342
2019 Hisada Y, Grover SP, Maqsood A, Houston R, Ay C, Noubouossie DF, Cooley BC, Wallén H, Key NS, Thålin C, Farkas ÁZ, Farkas VJ, Tenekedjiev K, Kolev K, Mackman N. Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors. Haematologica. PMID 31048354 DOI: 10.3324/Haematol.2019.217083  0.368
2019 Zhang N, Czepielewski RS, Jarjour NN, Erlich EC, Esaulova E, Saunders BT, Grover SP, Cleuren AC, Broze GJ, Edelson BT, Mackman N, Zinselmeyer BH, Randolph GJ. Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity. The Journal of Experimental Medicine. PMID 31048328 DOI: 10.1084/Jem.20182024  0.346
2019 Posthuma JJ, Posma JJN, van Oerle R, Leenders P, van Gorp RH, Jaminon AMG, Mackman N, Heitmeier S, Schurgers LJ, Ten Cate H, Spronk HMH. Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice. Scientific Reports. 9: 3909. PMID 30846818 DOI: 10.1038/S41598-019-40602-W  0.383
2019 Grover SP, Mackman N. Intrinsic Pathway of Coagulation and Thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 39: 331-338. PMID 30700128 DOI: 10.1161/Atvbaha.118.312130  0.315
2019 Posma JJ, Grover SP, Hisada Y, Owens AP, Antoniak S, Spronk HM, Mackman N. Roles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases Arteriosclerosis, Thrombosis, and Vascular Biology. 39: 13-24. PMID 30580574 DOI: 10.1161/Atvbaha.118.311655  0.418
2019 Zhang Y, Zhang G, Jian C, Wu C, Mackman N, Smyth S, Wei Y, Li Z. Inflammasome Activation Promotes Deep Vein Thrombosis through Pyroptosis Blood. 134: 3644-3644. DOI: 10.1182/Blood-2019-130439  0.395
2018 Lewis CS, Elnakat Thomas H, Orr-Asman M, Green LC, Boody RE, Matiash K, Karve A, Hisada YM, Davis HW, Qi X, Mercer C, Lucas FV, Aronow BJ, Mackman N, Versteeg HH, et al. mTOR kinase inhibition reduces tissue factor expression and growth of pancreatic neuroendocrine tumors. Journal of Thrombosis and Haemostasis : Jth. PMID 30472780 DOI: 10.1111/Jth.14342  0.334
2018 Hell L, Ay C, Posch F, Gebhart J, Koder S, Mackman N, Pabinger I, Thaler J. Low extracellular vesicle-associated tissue factor activity in patients with persistent lupus anticoagulant and a history of thrombosis. Annals of Hematology. PMID 30467688 DOI: 10.1007/S00277-018-3544-X  0.342
2018 Gezelius E, Flou Kristensen A, Bendahl PO, Hisada Y, Risom Kristensen S, Ek L, Bergman B, Wallberg M, Falkmer U, Mackman N, Pedersen S, Belting M. Coagulation biomarkers and prediction of venous thromboembolism and survival in small cell lung cancer: A sub-study of RASTEN - A randomized trial with low molecular weight heparin. Plos One. 13: e0207387. PMID 30412630 DOI: 10.1371/Journal.Pone.0207387  0.317
2018 Mackman N. The red blood cell death receptor and thrombosis Journal of Clinical Investigation. 128: 3747-3749. PMID 30102257 DOI: 10.1172/Jci122881  0.334
2018 Antoniak S, Tatsumi K, Schmedes CM, Grover SP, Pawlinski R, Mackman N. Protease-activated receptor 1 activation enhances doxorubicin-induced cardiotoxicity. Journal of Molecular and Cellular Cardiology. 122: 80-87. PMID 30098988 DOI: 10.1016/J.Yjmcc.2018.08.008  0.349
2018 Mackman N, Erlich JH. The uremic solute-AHR-tissue factor axis in vascular cells, mouse models and thrombosis in chronic kidney disease patients. Annals of Translational Medicine. 6: 225-225. PMID 30023388 DOI: 10.21037/Atm.2018.04.27  0.302
2018 Bode MF, Auriemma AC, Grover SP, Hisada Y, Rennie A, Bode WD, Vora R, Subramaniam S, Cooley B, Andrade-Gordon P, Antoniak S, Mackman N. The factor Xa inhibitor rivaroxaban reduces cardiac dysfunction in a mouse model of myocardial infarction. Thrombosis Research. 167: 128-134. PMID 29843086 DOI: 10.1016/J.Thromres.2018.05.015  0.346
2018 Mackman N, Antoniak S. Tissue factor and oxidative stress. Blood. 131: 2094-2095. PMID 29748170 DOI: 10.1182/Blood-2018-02-833673  0.381
2018 van Es N, Hisada Y, Di Nisio M, Cesarman G, Kleinjan A, Mahé I, Otten HM, Kamphuisen PW, Berckmans RJ, Büller HR, Mackman N, Nieuwland R. Extracellular vesicles exposing tissue factor for the prediction of venous thromboembolism in patients with cancer: A prospective cohort study. Thrombosis Research. 166: 54-59. PMID 29656167 DOI: 10.1016/J.Thromres.2018.04.009  0.364
2018 Jones SM, Mann A, Conrad K, Saum K, Hall DE, McKinney LM, Robbins N, Thompson J, Peairs AD, Camerer E, Rayner KJ, Tranter M, Mackman N, Owens AP. PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 29599135 DOI: 10.1161/Atvbaha.117.310082  0.336
2018 Grover SP, Bergmeier W, Mackman N. Platelet Signaling Pathways and New Inhibitors. Arteriosclerosis, Thrombosis, and Vascular Biology. 38. PMID 29563117 DOI: 10.1161/Atvbaha.118.310224  0.328
2018 Hisada Y, Thålin C, Lundström S, Wallén H, Mackman N. Comparison of microvesicle tissue factor activity in non-cancer severely ill patients and cancer patients Thrombosis Research. 165: 1-5. PMID 29539580 DOI: 10.1016/J.Thromres.2018.03.001  0.337
2018 Grover SP, Mackman N. Tissue Factor: An Essential Mediator of Hemostasis and Trigger of Thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 38: 709-725. PMID 29437578 DOI: 10.1161/Atvbaha.117.309846  0.468
2018 Hoesel B, Mussbacher M, Dikorman B, Salzmann M, Assinger A, Hell L, Thaler J, Basílio J, Moser B, Resch U, Paar H, Mackman N, Schmid JA. Androgen receptor dampens tissue factor expression via nuclear factor-κB and early growth response protein 1. Journal of Thrombosis and Haemostasis. 16: 749-758. PMID 29427323 DOI: 10.1111/Jth.13971  0.356
2018 Stark K, Schubert I, Joshi U, Kilani B, Hoseinpour P, Thakur M, Grünauer P, Pfeiler S, Schmidergall T, Stockhausen S, Bäumer M, Chandraratne S, von Brühl ML, Lorenz M, Coletti R, ... ... Mackman N, et al. Distinct Pathogenesis of Pancreatic Cancer Microvesicle-Associated Venous Thrombosis Identifies New Antithrombotic Targets In Vivo. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 29419408 DOI: 10.1161/Atvbaha.117.310262  0.304
2018 Spronk HMH, Padro T, Siland JE, Prochaska JH, Winters J, van der Wal AC, Posthuma JJ, Lowe G, d'Alessandro E, Wenzel P, Coenen DM, Reitsma PH, Ruf W, van Gorp RH, Koenen RR, ... ... Mackman N, et al. Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis. Thrombosis and Haemostasis. 118: 229-250. PMID 29378352 DOI: 10.1160/Th17-07-0492  0.385
2018 Hisada Y, Houston R, Maqsood A, Thalin C, Noubouossie DF, Wallen H, Kolev K, Cooley BC, Key NS, Mackman N. Abstract 041: Neutrophil Extracellular Traps Enhance Venous Thrombosis in Mice Bearing Human Pancreatic Tumors Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.041  0.317
2018 Subramaniam S, Botros F, Antoniak S, Mackman N, Fletcher C, Weiler H. Protease-Activated Receptor (PAR)-2 Activation Enhances TLR3-mediated Proinflammatory and Procoagulant Responses in ECs Atherosclerosis Supplements. 32: 103. DOI: 10.1016/J.Atherosclerosissup.2018.04.314  0.317
2017 Hisada Y, Mackman N. Mouse models of cancer-associated thrombosis. Thrombosis Research. 164. PMID 29306575 DOI: 10.1016/J.Thromres.2017.12.018  0.334
2017 Kopec AK, Spada AP, Contreras PC, Mackman N, Luyendyk JP. Caspase inhibition reduces hepatic tissue factor-driven coagulation in vitro and in vivo. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29228388 DOI: 10.1093/Toxsci/Kfx268  0.381
2017 Hisada Y, Ay C, Auriemma AC, Cooley BC, Mackman N. Human pancreatic tumors grown in mice release tissue factor-positive microvesicles that increase venous clot size. Journal of Thrombosis and Haemostasis. 15: 2208-2217. PMID 28834179 DOI: 10.1111/Jth.13809  0.374
2017 Hisada Y, Mackman N. Cancer-associated pathways and biomarkers of venous thrombosis. Blood. 130: 1499-1506. PMID 28807983 DOI: 10.1182/Blood-2017-03-743211  0.324
2017 Kopec AK, Abrahams SR, Thornton S, Palumbo JS, Mullins ES, Divanovic S, Weiler H, Owens AP, Mackman N, Goss A, van Ryn J, Luyendyk JP, Flick MJ. Thrombin promotes diet-induced obesity through fibrin-driven inflammation. The Journal of Clinical Investigation. PMID 28737512 DOI: 10.1172/Jci92744  0.305
2017 Solovey A, Somani A, Belcher JD, Milbauer L, Vincent L, Pawlinski R, Nath KA, Kelm RJ, Mackman N, O'Sullivan MG, Gupta K, Vercellotti GM, Hebbel RP. A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade. American Journal of Hematology. PMID 28699284 DOI: 10.1002/Ajh.24856  0.309
2017 Ay C, Hisada Y, Cooley BC, Mackman N. Factor XI deficient mice exhibit increased bleeding after injury to the saphenous vein Journal of Thrombosis and Haemostasis. 15: 1829-1833. PMID 28677246 DOI: 10.1111/Jth.13766  0.349
2017 Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, ... ... Mackman N, et al. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease. The Journal of Experimental Medicine. PMID 28566277 DOI: 10.1084/Jem.20161070  0.35
2017 Kral‐Pointner JB, Schrottmaier WC, Horvath V, Datler H, Hell L, Ay C, Niederreiter B, Jilma B, Schmid JA, Assinger A, Mackman N, Knapp S, Schabbauer G. Myeloid but not epithelial tissue factor exerts protective anti-inflammatory effects in acid aspiration-induced acute lung injury. Journal of Thrombosis and Haemostasis. 15: 1625-1639. PMID 28509332 DOI: 10.1111/Jth.13737  0.405
2017 Cohen JG, Prendergast E, Geddings JE, Walts AE, Agadjanian H, Hisada Y, Karlan BY, Mackman N, Walsh CS. Evaluation of venous thrombosis and tissue factor in epithelial ovarian cancer. Gynecologic Oncology. PMID 28501328 DOI: 10.1016/J.Ygyno.2017.04.021  0.381
2017 Bode MF, Mackman N. Erratum to "A combined deficiency of tissue factor and PAR-4 is associated with fatal pulmonary hemorrhage in mice" [Thromb. Res. 146 (2016) 46-50]. Thrombosis Research. 149: 95. PMID 27890308 DOI: 10.1016/J.Thromres.2016.11.005  0.361
2017 Antoniak S, Mackman N. Letter to Editor response: Endothelial cell tissue factor and coagulation Trends in Cardiovascular Medicine. 27: 157. PMID 27769630 DOI: 10.1016/J.Tcm.2016.09.012  0.367
2017 Schabbauer G, Kral-Pointner J, Schrottmaier W, Horvath V, Datler H, Hell L, Ay C, Niederreiter B, Jilma B, Schmid J, Assinger A, Mackman N, Knapp S. Myeloid but not epithelial tissue factor exerts protective anti-inflammatory properties in acid aspiration-induced acute lung injury Atherosclerosis. 263. DOI: 10.1016/J.Atherosclerosis.2017.06.524  0.321
2016 Hisada Y, Auriemma AC, Alexander W, Ay C, Mackman N. Detection of tissue factor-positive extracellular vesicles by laser scanning confocal microscopy. Thrombosis Research. 150: 65-72. PMID 28043041 DOI: 10.1016/J.Thromres.2016.12.021  0.329
2016 Ay C, Mackman N. Tissue Factor: Catch Me If You Can! Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2016706788. PMID 28029321 DOI: 10.1200/Jco.2016.70.6788  0.349
2016 Antoniak S, Cardenas JC, Buczek LJ, Church FC, Mackman N, Pawlinski R. Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation. Cardiology. 136: 258-268. PMID 27880950 DOI: 10.1159/000452269  0.3
2016 Antoniak S, Tatsumi K, Bode M, Vanja S, Williams JC, Mackman N. Protease-Activated Receptor 1 Enhances Poly I:C Induction of the Antiviral Response in Macrophages and Mice. Journal of Innate Immunity. PMID 27820939 DOI: 10.1159/000450853  0.371
2016 Hisada Y, Alexander W, Kasthuri R, Voorhees P, Mobarrez F, Taylor A, McNamara C, Wallen H, MarcoWitkowski, Key NS, Rauch U, Mackman N. Corrigendum to "Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays" [Thromb. Res. 139 (2016) 90-97]. Thrombosis Research. 147: 63. PMID 27676256 DOI: 10.1016/J.Thromres.2016.09.009  0.364
2016 Claussen C, Rausch AV, Lezius S, Amirkhosravi A, Davila M, Francis JL, Hisada YM, Mackman N, Bokemeyer C, Schmalfeldt B, Mahner S, Langer F. Corrigendum to 'Microvesicle-associated tissue factor procoagulant activity for the preoperative diagnosis of ovarian cancer", [Thromb. Res. 141 (2016) 39-48]. Thrombosis Research. PMID 27640329 DOI: 10.1016/J.Thromres.2016.09.008  0.35
2016 Bode MF, Mackman N. A combined deficiency of tissue factor and PAR-4 is associated with fatal pulmonary hemorrhage in mice. Thrombosis Research. 146: 46-50. PMID 27586081 DOI: 10.1016/J.Thromres.2016.08.023  0.366
2016 Simmers MB, Cole BK, Ogletree ML, Chen Z, Xu Y, Kong LJ, Mackman N, Blackman BR, Wamhoff BR. Hemodynamics associated with atrial fibrillation directly alters thrombotic potential of endothelial cells. Thrombosis Research. 143: 34-39. PMID 27179130 DOI: 10.1016/J.Thromres.2016.04.022  0.332
2016 Hisada Y, Geddings JE, Boulaftali Y, Getz TM, Whelihan M, Fuentes R, Dee R, Cooley BC, Key NS, Wolberg AS, Bergmeier W, Mackman N. OC-04 - Tissue factor positive microvesicles activate platelets in vitro and in vivo and enhance thrombosis in mice. Thrombosis Research. 140: S169-70. PMID 27161676 DOI: 10.1016/S0049-3848(16)30121-9  0.433
2016 Jagadeeswaran P, Cooley BC, Gross PL, Mackman N. Animal Models of Thrombosis From Zebrafish to Nonhuman Primates: Use in the Elucidation of New Pathologic Pathways and the Development of Antithrombotic Drugs. Circulation Research. 118: 1363-79. PMID 27126647 DOI: 10.1161/Circresaha.115.306823  0.327
2016 Boulaftali Y, Owens AP, Beale A, Piatt R, Casari C, Lee RH, Conley PB, Paul DS, Mackman N, Bergmeier W. CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26988592 DOI: 10.1161/Atvbaha.115.306347  0.326
2016 Claussen C, Rausch AV, Lezius S, Amirkhosravi A, Davila M, Francis JL, Hisada YM, Mackman N, Bokemeyer C, Schmalfeldt B, Mahner S, Langer F. Microvesicle-associated tissue factor procoagulant activity for the preoperative diagnosis of ovarian cancer. Thrombosis Research. 141: 39-48. PMID 26967531 DOI: 10.1016/J.Thromres.2016.03.002  0.323
2016 Unruh D, Ünlü B, Lewis CS, Qi X, Chu Z, Sturm R, Keil R, Ahmad SA, Sovershaev T, Adam M, Van Dreden P, Woodhams BJ, Ramchandani D, Weber GF, Rak JW, ... ... Mackman N, et al. Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma. Oncotarget. PMID 26967388 DOI: 10.18632/Oncotarget.7955  0.374
2016 Antoniak S, Tatsumi K, Hisada Y, Milner JJ, Neidich SD, Shaver CM, Pawlinski R, Beck MA, Bastarache JA, Mackman N. Tissue factor Deficiency Increases Alveolar Hemorrhage and Death in Influenza A Infected Mice. Journal of Thrombosis and Haemostasis : Jth. PMID 26947929 DOI: 10.1111/Jth.13307  0.311
2016 Shaver CM, Grove BS, Clune JK, Mackman N, Ware LB, Bastarache JA. Myeloid tissue factor does not modulate lung inflammation or permeability during experimental acute lung injury. Scientific Reports. 6: 22249. PMID 26924425 DOI: 10.1038/Srep22249  0.365
2016 Hisada Y, Alexander W, Kasthuri R, Voorhees P, Mobarrez F, Taylor A, McNamara C, Wallen H, Witkowski M, Key NS, Rauch U, Mackman N. Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays. Thrombosis Research. 139: 90-7. PMID 26916302 DOI: 10.1016/J.Thromres.2016.01.011  0.433
2016 Mackman N. The Clot Thickens in Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 36: 425-6. PMID 26912742 DOI: 10.1161/Atvbaha.116.307094  0.368
2016 Mackman N, Roubey RAS. Is Leukocyte Tissue Factor the key to Venous Thrombosis in Antiphospholipid Syndrome Journal of Thrombosis and Haemostasis. 14: 1008-1010. PMID 26879261 DOI: 10.1111/Jth.13296  0.344
2016 Antoniak S, Mackman N. Editorial Commentary: Tissue factor expression by the endothelium: Coagulation or inflammation? Trends in Cardiovascular Medicine. 26: 304-5. PMID 26850939 DOI: 10.1016/J.Tcm.2015.12.002  0.395
2016 Sparkenbaugh EM, Chantrathammachart P, Chandarajoti K, Mackman N, Key NS, Pawlinski R. Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease. Blood. 127: 1371-3. PMID 26817955 DOI: 10.1182/Blood-2015-11-681114  0.34
2016 Ay C, Hisada Y, Cooley BC, Mackman N. Bleeding in Factor XI Deficient Mice Blood. 128: 3766-3766. DOI: 10.1182/Blood.V128.22.3766.3766  0.338
2015 Geddings JE, Hisada Y, Boulaftali Y, Getz TM, Whelihan M, Fuentes R, Dee R, Cooley BC, Key NS, Wolberg AS, Bergmeier W, Mackman N. Tissue Factor-positive Tumor Microvesicles Activate Platelets and Enhance Thrombosis in Mice. Journal of Thrombosis and Haemostasis : Jth. PMID 26516108 DOI: 10.1111/Jth.13181  0.413
2015 Mitchel JA, Antoniak S, Lee JH, Kim SH, McGill M, Kasahara DI, Randell SH, Israel E, Shore SA, Mackman N, Park JA. IL-13 Augments Compressive Stress-induced Tissue Factor Expression in Human Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology. PMID 26407210 DOI: 10.1165/Rcmb.2015-0252Oc  0.344
2015 Laplante P, Fuentes R, Salem D, Subang R, Gillis MA, Hachem A, Farhat N, Qureshi ST, Fletcher CA, Roubey RA, Merhi Y, Thorin É, Levine JS, Mackman N, Rauch J. Antiphospholipid antibody-mediated effects in an arterial model of thrombosis are dependent on Toll-like receptor 4. Lupus. PMID 26391610 DOI: 10.1177/0961203315603146  0.381
2015 Rautou PE, Tatsumi K, Antoniak S, Owens AP, Sparkenbaugh E, Holle LA, Wolberg AS, Kopec AK, Pawlinski R, Luyendyk JP, Mackman N. Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury. Journal of Hepatology. PMID 26325534 DOI: 10.1016/J.Jhep.2015.08.017  0.343
2015 Nickel KF, Ronquist G, Langer F, Labberton L, Fuchs TA, Bokemeyer C, Sauter G, Graefen M, Mackman N, Stavrou EX, Ronquist G, Renné T. The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis. Blood. 126: 1379-89. PMID 26153520 DOI: 10.1182/Blood-2015-01-622811  0.358
2015 Williams JC, Klein TW, Goldberger BA, Sleasman JW, Mackman N, Goodenow MM. Δ(9)-Tetrahydrocannabinol (THC) enhances lipopolysaccharide-stimulated tissue factor in human monocytes and monocyte-derived microvesicles. Journal of Inflammation (London, England). 12: 39. PMID 26085816 DOI: 10.1186/S12950-015-0084-1  0.394
2015 Tatsumi K, Mackman N. Tissue Factor and Atherothrombosis. Journal of Atherosclerosis and Thrombosis. 22: 543-9. PMID 26016513 DOI: 10.5551/Jat.30940  0.423
2015 Hisada Y, Geddings JE, Ay C, Mackman N. Venous thrombosis and cancer: from mouse models to clinical trials. Journal of Thrombosis and Haemostasis. 13: 1372-1382. PMID 25988873 DOI: 10.1111/Jth.13009  0.361
2015 Shaver CM, Grove BS, Putz N, Clune JK, Lawson WE, Carnahan RH, Mackman N, Ware LB, Bastarache JA. Lung Epithelial Tissue Factor Regulates Alveolar Pro-coagulant Activity and Permeability in Direct Acute Lung Injury. American Journal of Respiratory Cell and Molecular Biology. PMID 25884207 DOI: 10.1165/Rcmb.2014-0179Oc  0.362
2015 Stefanini L, Paul DS, Robledo RF, Chan ER, Getz TM, Campbell RA, Kechele DO, Casari C, Piatt R, Caron KM, Mackman N, Weyrich AS, Parrott MC, Boulaftali Y, Adams MD, et al. RASA3 is a critical inhibitor of RAP1-dependent platelet activation. The Journal of Clinical Investigation. 125: 1419-32. PMID 25705885 DOI: 10.1172/Jci77993  0.341
2015 Sparkenbaugh EM, Chantrathammachart P, Wang S, Jonas W, Kirchhofer D, Gailani D, Gruber A, Kasthuri R, Key NS, Mackman N, Pawlinski R. Excess of heme induces tissue factor-dependent activation of coagulation in mice. Haematologica. 100: 308-14. PMID 25596265 DOI: 10.3324/Haematol.2014.114728  0.481
2015 Getz TM, Piatt R, Petrich BG, Monroe D, Mackman N, Bergmeier W. Novel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition. Journal of Thrombosis and Haemostasis : Jth. 13: 417-25. PMID 25442192 DOI: 10.1182/Blood.V124.21.4177.4177  0.339
2015 Stavrou EX, Fang C, Merkulova A, Alhalabi O, Grobe N, Antoniak S, Mackman N, Schmaier AH. Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor. Blood. 125: 710-9. PMID 25339356 DOI: 10.1182/Blood-2014-01-550285  0.4
2015 Rondina MT, Tatsumi K, Bastarache JA, Mackman N. Plasma Levels of IL-8 and Microparticle Tissue Factor Activity Are Associated with Mortality in Patients with Primary Influenza A/H1N1 Infection Blood. 126: 3544-3544. DOI: 10.1182/Blood.V126.23.3544.3544  0.306
2015 Kidd L, Geddings J, Hisada Y, Sueda M, Concannon T, Nichols T, Merricks E, Mackman N. Procoagulant Microparticles in Dogs with Immune-Mediated Hemolytic Anemia Journal of Veterinary Internal Medicine. 29: 908-916. DOI: 10.1111/Jvim.12583  0.318
2014 Kothari H, Keshava S, Vatsyayan R, Mackman N, Rao LV, Pendurthi UR. Role of tissue factor in Mycobacterium tuberculosis-induced inflammation and disease pathogenesis. Plos One. 9: e114141. PMID 25462128 DOI: 10.1182/Blood.V124.21.1505.1505  0.33
2014 Magnus N, Meehan B, Garnier D, Hashemi M, Montermini L, Lee TH, Milsom C, Pawlinski R, Ohlfest J, Anderson M, Mackman N, Rak J. The contribution of tumor and host tissue factor expression to oncogene-driven gliomagenesis. Biochemical and Biophysical Research Communications. 454: 262-8. PMID 25450387 DOI: 10.1016/J.Bbrc.2014.10.041  0.363
2014 Bode MF, Mackman N. Protective and pathological roles of tissue factor in the heart. Hamostaseologie. 35: 37-46. PMID 25434707 DOI: 10.5482/Hamo-14-09-0042  0.417
2014 Iqbal MB, Johns M, Cao J, Liu Y, Yu SC, Hyde GD, Laffan MA, Marchese FP, Cho SH, Clark AR, Gavins FN, Woollard KJ, Blackshear PJ, Mackman N, Dean JL, et al. PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression. Blood. 124: 3646-55. PMID 25293769 DOI: 10.1182/Blood-2014-07-588046  0.398
2014 Gangadharan B, Delignat S, Ollivier V, Gupta N, Mackman N, Kaveri SV, Lacroix-Desmazes S. Role of coagulation-associated processes on factor VIII immunogenicity in a mouse model of severe hemophilia A. Journal of Thrombosis and Haemostasis : Jth. 12: 2065-9. PMID 25267332 DOI: 10.1111/Jth.12740  0.341
2014 Tatsumi K, Antoniak S, Monroe DM, Khorana AA, Mackman N. Evaluation of a new commercial assay to measure microparticle tissue factor activity in plasma: communication from the SSC of the ISTH. Journal of Thrombosis and Haemostasis : Jth. 12: 1932-4. PMID 25186801 DOI: 10.1111/Jth.12718  0.324
2014 Vatsyayan R, Kothari H, Mackman N, Pendurthi UR, Rao LV. Inactivation of factor VIIa by antithrombin in vitro, ex vivo and in vivo: role of tissue factor and endothelial cell protein C receptor. Plos One. 9: e103505. PMID 25102166 DOI: 10.1371/Journal.Pone.0103505  0.439
2014 Lopez M, Kopec AK, Joshi N, Geddings JE, Cline H, Towery KL, Rockwell CE, Mackman N, Luyendyk JP. Fas-induced apoptosis increases hepatocyte tissue factor procoagulant activity in vitro and in vivo. Toxicological Sciences : An Official Journal of the Society of Toxicology. 141: 453-64. PMID 25015658 DOI: 10.1093/Toxsci/Kfu139  0.395
2014 Aleman MM, Byrnes JR, Wang JG, Tran R, Lam WA, Paola JD, Mackman N, Degen JL, Flick MJ, Wolberg AS. Factor XIII activity mediates red blood cell retention in venous thrombi Journal of Clinical Investigation. 124: 3590-3600. PMID 24983320 DOI: 10.1172/Jci75386  0.376
2014 Bode M, Mackman N. Regulation of tissue factor gene expression in monocytes and endothelial cells: Thromboxane A2 as a new player. Vascular Pharmacology. 62: 57-62. PMID 24858575 DOI: 10.1016/J.Vph.2014.05.005  0.422
2014 Mackman N, Antoniak S. Roles of PAR1 and PAR2 in viral myocarditis. Thrombosis Research. 133: S18-20. PMID 24759133 DOI: 10.1016/J.Thromres.2014.03.011  0.322
2014 Antoniak S, Mackman N. Multiple roles of the coagulation protease cascade during virus infection. Blood. 123: 2605-13. PMID 24632711 DOI: 10.1182/Blood-2013-09-526277  0.359
2014 Geddings JE, Mackman N. New players in haemostasis and thrombosis. Thrombosis and Haemostasis. 111: 570-4. PMID 24573314 DOI: 10.1160/Th13-10-0812  0.421
2014 Magnus N, Garnier D, Meehan B, McGraw S, Lee TH, Caron M, Bourque G, Milsom C, Jabado N, Trasler J, Pawlinski R, Mackman N, Rak J. Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations. Proceedings of the National Academy of Sciences of the United States of America. 111: 3544-9. PMID 24520174 DOI: 10.1073/Pnas.1314118111  0.387
2014 Rautou PE, Vion AC, Luyendyk JP, Mackman N. Circulating microparticle tissue factor activity is increased in patients with cirrhosis. Hepatology (Baltimore, Md.). 60: 1793-5. PMID 24470301 DOI: 10.1002/Hep.27033  0.372
2014 Geddings J, Aleman MM, Wolberg A, von Brühl ML, Massberg S, Mackman N. Strengths and weaknesses of a new mouse model of thrombosis induced by inferior vena cava stenosis: communication from the SSC of the ISTH. Journal of Thrombosis and Haemostasis : Jth. 12: 571-3. PMID 24460606 DOI: 10.1111/Jth.12510  0.311
2014 Sparkenbaugh EM, Chantrathammachart P, Mickelson J, van Ryn J, Hebbel RP, Monroe DM, Mackman N, Key NS, Pawlinski R. Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease. Blood. 123: 1747-56. PMID 24449213 DOI: 10.1182/Blood-2013-08-523936  0.426
2014 Owens AP, Mackman N. The antithrombotic effects of statins. Annual Review of Medicine. 65: 433-45. PMID 24422578 DOI: 10.1146/Annurev-Med-051812-145304  0.366
2014 Antoniak S, Mackman N. Coagulation, protease-activated receptors, and viral myocarditis. Journal of Cardiovascular Translational Research. 7: 203-11. PMID 24203054 DOI: 10.1007/S12265-013-9515-7  0.361
2014 Yokota N, Zarpellon A, Chakrabarty S, Bogdanov VY, Gruber A, Castellino FJ, Mackman N, Ellies LG, Weiler H, Ruggeri ZM, Ruf W. Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice. Journal of Thrombosis and Haemostasis : Jth. 12: 71-81. PMID 24175924 DOI: 10.1111/Jth.12442  0.404
2014 Geddings JE, Mackman N. Comment on "tissue factor expressed by microparticles is associated with mortality but not with thrombosis in cancer patients". Thrombosis and Haemostasis. 111: 180-1. PMID 24153434 DOI: 10.1160/Th13-07-0599  0.351
2014 Owens AP, Byrnes JR, Mackman N. Hyperlipidemia, tissue factor, coagulation, and simvastatin Trends in Cardiovascular Medicine. 24: 95-98. PMID 24016468 DOI: 10.1016/J.Tcm.2013.07.003  0.411
2014 Antoniak S, Tatsumi K, Mackman N. The Tissue Factor/Thrombin/Protease-Activated Receptor 1 Pathway Enhances Double-Strand RNA Induced Immune Responses in Macrophages Blood. 124: 4114-4114. DOI: 10.1182/Blood.V124.21.4114.4114  0.379
2014 Tatsumi K, Antoniak S, Milner J, Beck M, Mackman N. Impaired Hemostasis Caused By Deficit of Tissue Factor-Triggered Blood Coagulation Leads to Alveolar Hemorrhages and Increased Mortality in Influenza A Infection Blood. 124: 2805-2805. DOI: 10.1182/Blood.V124.21.2805.2805  0.354
2014 Unruh D, Qi X, Chu Z, Sturm R, Keil R, Ahmad SA, Sovershaev T, Rak JW, Mackman N, Versteeg HH, Bogdanov VY. Alternatively Spliced Tissue Factor As a New Therapeutic Target in Pancreatic Cancer Blood. 124: 2801-2801. DOI: 10.1182/Blood.V124.21.2801.2801  0.371
2014 Tatsumi K, Antoniak S, Mackman N. Role of the Thrombin-PAR-1 Pathway in Coxsackievirus Induced Hepatitis Blood. 124: 1470-1470. DOI: 10.1182/Blood.V124.21.1470.1470  0.356
2013 Weithauser A, Bobbert P, Antoniak S, Böhm A, Rauch BH, Klingel K, Savvatis K, Kroemer HK, Tschope C, Stroux A, Zeichhardt H, Poller W, Mackman N, Schultheiss HP, Rauch U. Protease-activated receptor-2 regulates the innate immune response to viral infection in a coxsackievirus B3-induced myocarditis. Journal of the American College of Cardiology. 62: 1737-45. PMID 23871888 DOI: 10.1016/J.Jacc.2013.05.076  0.344
2013 Bharthuar A, Khorana AA, Hutson A, Wang JG, Key NS, Mackman N, Iyer RV. Circulating microparticle tissue factor, thromboembolism and survival in pancreaticobiliary cancers. Thrombosis Research. 132: 180-4. PMID 23856554 DOI: 10.1016/J.Thromres.2013.06.026  0.384
2013 Geddings JE, Mackman N. Tumor-derived tissue factor-positive microparticles and venous thrombosis in cancer patients. Blood. 122: 1873-80. PMID 23798713 DOI: 10.1182/Blood-2013-04-460139  0.364
2013 Mackman N, Luther T. Platelet tissue factor: to be or not to be. Thrombosis Research. 132: 3-5. PMID 23731564 DOI: 10.1016/J.Thromres.2013.05.009  0.363
2013 Luo D, Lin JS, Parent MA, Mullarky-Kanevsky I, Szaba FM, Kummer LW, Duso DK, Tighe M, Hill J, Gruber A, Mackman N, Gailani D, Smiley ST. Fibrin facilitates both innate and T cell-mediated defense against Yersinia pestis. Journal of Immunology (Baltimore, Md. : 1950). 190: 4149-61. PMID 23487423 DOI: 10.4049/Jimmunol.1203253  0.351
2013 Thaler J, Ay C, Mackman N, Metz-Schimmerl S, Stift J, Kaider A, Müllauer L, Gnant M, Scheithauer W, Pabinger I. Microparticle-associated tissue factor activity in patients with pancreatic cancer: correlation with clinicopathological features. European Journal of Clinical Investigation. 43: 277-85. PMID 23398637 DOI: 10.1111/Eci.12042  0.372
2013 Antoniak S, Owens AP, Baunacke M, Williams JC, Lee RD, Weithäuser A, Sheridan PA, Malz R, Luyendyk JP, Esserman DA, Trejo J, Kirchhofer D, Blaxall BC, Pawlinski R, Beck MA, ... ... Mackman N, et al. PAR-1 contributes to the innate immune response during viral infection. The Journal of Clinical Investigation. 123: 1310-22. PMID 23391721 DOI: 10.1172/Jci66125  0.359
2013 Rautou PE, Mackman N. Microvesicles as risk markers for venous thrombosis. Expert Review of Hematology. 6: 91-101. PMID 23373784 DOI: 10.1586/Ehm.12.74  0.363
2013 Boulaftali Y, Hess PR, Getz TM, Cholka A, Stolla M, Mackman N, Owens AP, Ware J, Kahn ML, Bergmeier W. Platelet ITAM signaling is critical for vascular integrity in inflammation. The Journal of Clinical Investigation. 123: 908-16. PMID 23348738 DOI: 10.1172/Jci65154  0.352
2013 Sullivan BP, Kopec AK, Joshi N, Cline H, Brown JA, Bishop SC, Kassel KM, Rockwell C, Mackman N, Luyendyk JP. Hepatocyte tissue factor activates the coagulation cascade in mice. Blood. 121: 1868-74. PMID 23305736 DOI: 10.1182/Blood-2012-09-455436  0.436
2013 Mackman N. Uremic serum and ubiquitylation of tissue factor. Circulation. 127: 320-1. PMID 23269490 DOI: 10.1161/Circulationaha.112.154666  0.333
2013 Zwicker JI, Mayer EL, Campigotto F, Geddings J, Christina H, Bowley S, Wulf G, Horowitz G, Neuberg DS, Mackman N, Furie B. Rosuvastatin Lowers Circulating Tissue Factor Antigen-Bearing Microparticles In Metastatic Breast Cancer: A Phase II, Multi-Dose, Randomized Trial (MicroSTAT Trial) Blood. 122: 579-579. DOI: 10.1182/Blood.V122.21.579.579  0.378
2013 Aleman MM, Byrnes JR, Wang J, Mackman N, Degen JL, Flick MJ, Wolberg AS. Fibrin Crosslinking Is Required For Retention Of Red Blood Cells In Venous Thrombi, Blood. 122: 451-451. DOI: 10.1182/Blood.V122.21.451.451  0.301
2013 Antoniak S, Tatsumi K, Milner J, Beck M, Mackman N. Impaired Hemostasis Leads To Alveolar Hemorrhages and Increased Mortality In Influenza A Infection Blood. 122: 1095-1095. DOI: 10.1182/Blood.V122.21.1095.1095  0.354
2013 Magnus N, Garnier D, Meehan B, Hashemi M, Lee T, Milsom C, Jabado N, Pawlinski R, Mackman N, Rak J. Abstract 1091: Procoagulant receptor tissue factor provokes the escape from brain tumor dormancy. Cancer Research. 73: 1091-1091. DOI: 10.1158/1538-7445.Am2013-1091  0.309
2013 Iqbal MB, Johns M, Yu S, Hyde GD, Laffan MA, Gavins FN, Blackshear P, Dean JL, Mackman N, Boothby M, Haskard DO. 205 Poly(Adp-Ribose) Polymerase-14 Interacts With Tristetraprolin To Selectively Regulate Tissue Factor Mrna Stability: A Novel Role For Adp-Ribosylation In Regulating Mrna Turnover And Thrombosis Heart. 99. DOI: 10.1136/Heartjnl-2013-304019.205  0.346
2013 Iqbal MB, Johns M, Yu SC, Hyde GD, Gavins FN, Blackshear PJ, Mackman N, Dean JL, Boothby M, Haskard DO. Poly(ADP-ribose) polymerase -14 interacts with tristetraprolin to selectively regulate tissue factor mRNA stability: a novel role for ADP-ribosylation in regulating mRNA turnover and thrombosis European Heart Journal. 34: 968-968. DOI: 10.1093/Eurheartj/Eht308.968  0.31
2012 Bastarache JA, Sebag SC, Clune JK, Grove BS, Lawson WE, Janz DR, Roberts LJ, Dworski R, Mackman N, Ware LB. Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. Thorax. 67: 1032-9. PMID 23033361 DOI: 10.1136/Thoraxjnl-2012-201781  0.349
2012 Owens AP, Mackman N. Role of tissue factor in atherothrombosis. Current Atherosclerosis Reports. 14: 394-401. PMID 22886473 DOI: 10.1007/S11883-012-0269-5  0.428
2012 Darbousset R, Thomas GM, Mezouar S, Frère C, Bonier R, Mackman N, Renné T, Dignat-George F, Dubois C, Panicot-Dubois L. Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation. Blood. 120: 2133-43. PMID 22837532 DOI: 10.1182/Blood-2012-06-437772  0.416
2012 Marchi R, Walton BL, McGary CS, Lin FC, Ma AD, Pawlinski R, MacKman N, Campbell RA, Paola JD, Wolberg AS. Dysregulated coagulation associated with hypofibrinogenaemia and plasma hypercoagulability: Implications for identifying coagulopathic mechanisms in humans Thrombosis and Haemostasis. 108: 516-526. PMID 22836883 DOI: 10.1160/Th12-05-0355  0.356
2012 Lee R, Williams JC, Mackman N. P2X7 regulation of macrophage tissue factor activity and microparticle generation. Journal of Thrombosis and Haemostasis : Jth. 10: 1965-7. PMID 22759201 DOI: 10.1111/J.1538-7836.2012.04842.X  0.394
2012 Mackman N. New insights into the mechanisms of venous thrombosis. The Journal of Clinical Investigation. 122: 2331-6. PMID 22751108 DOI: 10.1172/Jci60229  0.413
2012 Chantrathammachart P, Mackman N, Sparkenbaugh E, Wang JG, Parise LV, Kirchhofer D, Key NS, Pawlinski R. Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease. Blood. 120: 636-46. PMID 22661702 DOI: 10.1182/Blood-2012-04-424143  0.447
2012 Wang JG, Geddings JE, Aleman MM, Cardenas JC, Chantrathammachart P, Williams JC, Kirchhofer D, Bogdanov VY, Bach RR, Rak J, Church FC, Wolberg AS, Pawlinski R, Key NS, Yeh JJ, ... Mackman N, et al. Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer. Blood. 119: 5543-52. PMID 22547577 DOI: 10.1182/Blood-2012-01-402156  0.408
2012 Weitz IC, Razavi P, Rochanda L, Zwicker J, Furie B, Manly D, Mackman N, Green R, Liebman HA. Eculizumab therapy results in rapid and sustained decreases in markers of thrombin generation and inflammation in patients with PNH independent of its effects on hemolysis and microparticle formation. Thrombosis Research. 130: 361-8. PMID 22542362 DOI: 10.1016/J.Thromres.2012.04.001  0.342
2012 van Doormaal F, Kleinjan A, Berckmans RJ, Mackman N, Manly D, Kamphuisen PW, Richel DJ, Büller HR, Sturk A, Nieuwland R. Coagulation activation and microparticle-associated coagulant activity in cancer patients. An exploratory prospective study. Thrombosis and Haemostasis. 108: 160-5. PMID 22535219 DOI: 10.1160/Th12-02-0099  0.368
2012 Thaler J, Ay C, Mackman N, Bertina RM, Kaider A, Marosi C, Key NS, Barcel DA, Scheithauer W, Kornek G, Zielinski C, Pabinger I. Microparticle-associated tissue factor activity, venous thromboembolism and mortality in pancreatic, gastric, colorectal and brain cancer patients. Journal of Thrombosis and Haemostasis : Jth. 10: 1363-70. PMID 22520016 DOI: 10.1111/J.1538-7836.2012.04754.X  0.372
2012 von Brühl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, Khandoga A, Tirniceriu A, Coletti R, Köllnberger M, Byrne RA, Laitinen I, Walch A, Brill A, Pfeiler S, ... ... Mackman N, et al. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. The Journal of Experimental Medicine. 209: 819-35. PMID 22451716 DOI: 10.1084/Jem.20112322  0.423
2012 Owens AP, Mackman N. Sources of tissue factor that contribute to thrombosis after rupture of an atherosclerotic plaque. Thrombosis Research. 129: S30-3. PMID 22444158 DOI: 10.1016/J.Thromres.2012.02.026  0.418
2012 Kasthuri RS, Glover SL, Jonas W, McEachron T, Pawlinski R, Arepally GM, Key NS, Mackman N. PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcγRI. Blood. 119: 5285-93. PMID 22394597 DOI: 10.1182/Blood-2011-06-359430  0.422
2012 Rautou PE, Mackman N. Del-etion of microvesicles from the circulation. Circulation. 125: 1601-4. PMID 22388321 DOI: 10.1161/Circulationaha.112.094920  0.356
2012 Mackman N. Mouse models, risk factors, and treatments of venous thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 554-5. PMID 22345592 DOI: 10.1161/Atvbaha.112.246173  0.342
2012 Boltzen U, Eisenreich A, Antoniak S, Weithaeuser A, Fechner H, Poller W, Schultheiss HP, Mackman N, Rauch U. Alternatively spliced tissue factor and full-length tissue factor protect cardiomyocytes against TNF-α-induced apoptosis Journal of Molecular and Cellular Cardiology. 52: 1056-1065. PMID 22326437 DOI: 10.1016/J.Yjmcc.2012.01.015  0.367
2012 Owens AP, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton JA, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, ... ... Mackman N, et al. Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. The Journal of Clinical Investigation. 122: 558-68. PMID 22214850 DOI: 10.1172/Jci58969  0.453
2012 Williams JC, Mackman N. Tissue factor in health and disease. Frontiers in Bioscience (Elite Edition). 4: 358-72. PMID 22201878 DOI: 10.2741/383  0.413
2012 Hampton AL, Diaz JA, Hawley AE, Wrobleski SK, Wang JG, Lee RD, Kirchhofer D, Sigler RE, Wakefield TW, Mackman N, Myers DD. Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model. Thrombosis Research. 130: 640-5. PMID 22192154 DOI: 10.1016/J.Thromres.2011.11.027  0.422
2012 Cronan MR, Nakamura K, Johnson NL, Granger DA, Cuevas BD, Wang JG, Mackman N, Scott JE, Dohlman HG, Johnson GL. Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis. Oncogene. 31: 3889-900. PMID 22139075 DOI: 10.1038/Onc.2011.544  0.303
2012 Boles JC, Williams JC, Hollingsworth RM, Wang JG, Glover SL, Owens AP, Barcel DA, Kasthuri RS, Key NS, Mackman N. Anthracycline treatment of the human monocytic leukemia cell line THP-1 increases phosphatidylserine exposure and tissue factor activity. Thrombosis Research. 129: 197-203. PMID 21762960 DOI: 10.1182/Blood.V116.21.1136.1136  0.386
2012 Lee RD, Barcel DA, Williams JC, Wang JG, Boles JC, Manly DA, Key NS, Mackman N. Pre-analytical and analytical variables affecting the measurement of plasma-derived microparticle tissue factor activity. Thrombosis Research. 129: 80-5. PMID 21737126 DOI: 10.1016/J.Thromres.2011.06.004  0.437
2012 Geddings JE, Wang J, Cardenas JC, Chantrathammachart P, Williams JC, Back RR, Church FC, Pawlinski R, Key N, Yeh JJ, Mackman N. Relationship between tissue factor expression by human pancreatic cancer cells and activation of coagulation and thrombosis in a mouse model. Journal of Clinical Oncology. 30. DOI: 10.1200/Jco.2012.30.15_Suppl.E14505  0.435
2012 Sparkenbaugh EM, Chantrathammachart P, Mackman N, Key NS, Pawlinski R. Heme Induces Systemic Activation of Coagulation in Vivo in a Tissue Factor-Dependent Manner Blood. 120: 820-820. DOI: 10.1182/Blood.V120.21.820.820  0.419
2012 Chantrathammachart P, Sparkenbaugh EM, Mackman N, Key NS, Pawlinski R. Protease Activated Receptor 2 (PAR-2) Promotes Vascular Inflammation in a Mouse Model of Sickle Cell Disease Blood. 120: 375-375. DOI: 10.1182/Blood.V120.21.375.375  0.4
2012 Bradford RL, Chantrathammachart P, Mooberry M, Mazepa M, Wang JG, Glover SL, Gabriel DA, Mackman N, Key NS. Novel approaches in the detection of binding of cancer cell microparticles to activated platelets Thrombosis Research. 129. DOI: 10.1016/S0049-3848(12)70129-9  0.312
2012 Wang J, Gambone J, Aleman M, Cardenas J, Chantrathammachart P, Williams J, Kirchhofer D, Bogdanov V, Bach R, Church F, Wolberg A, Pawlinski R, Key N, Yeh J, Mackman N. Human pancreatic cancer cell tissue factor activates coagulation in a mousemodel Thrombosis Research. 129: S171. DOI: 10.1016/S0049-3848(12)70077-4  0.383
2012 Chantrathammachart P, Key NS, Mackman N, Pawlinski R. Tissue factor-dependent activation of coagulation contributes to the inflammation in a mouse model of sickle cell disease Vascular Pharmacology. 56: 376. DOI: 10.1016/J.Vph.2011.08.191  0.411
2011 Williams JC, Lee RD, Doerschuk CM, Mackman N. Effect of PAR-2 Deficiency in Mice on KC Expression after Intratracheal LPS Administration. Journal of Signal Transduction. 2011: 415195. PMID 22175012 DOI: 10.1155/2011/415195  0.347
2011 Gambone JE, Owens AP, Mackman N. Comment on "tissue factor-dependent chemokine production aggravates experimental colitis". Molecular Medicine (Cambridge, Mass.). 17: 1131; author reply 1. PMID 22027905 DOI: 10.2119/Molmed.2011.00303  0.331
2011 Mackman N, Davis GE. Blood coagulation and blood vessel development: is tissue factor the missing link? Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 2364-6. PMID 22011746 DOI: 10.1161/Atvbaha.111.236703  0.443
2011 Kassel KM, Owens AP, Rockwell CE, Sullivan BP, Wang R, Tawfik O, Li G, Guo GL, Mackman N, Luyendyk JP. Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet. The American Journal of Pathology. 179: 2278-89. PMID 21907177 DOI: 10.1016/J.Ajpath.2011.07.015  0.346
2011 Liu Y, Jiang P, Capkova K, Xue D, Ye L, Sinha SC, Mackman N, Janda KD, Liu C. Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy. Cancer Research. 71: 6492-502. PMID 21880589 DOI: 10.1158/0008-5472.Can-11-1145  0.368
2011 McEachron TA, Church FC, Mackman N. Regulation of thrombin-induced plasminogen activator inhibitor-1 in 4T1 murine breast cancer cells. Blood Coagulation & Fibrinolysis : An International Journal in Haemostasis and Thrombosis. 22: 576-82. PMID 21799402 DOI: 10.1097/Mbc.0B013E3283497647  0.362
2011 Luo D, Szaba FM, Kummer LW, Plow EF, Mackman N, Gailani D, Smiley ST. Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica. Journal of Immunology (Baltimore, Md. : 1950). 187: 1866-76. PMID 21724997 DOI: 10.4049/Jimmunol.1101094  0.401
2011 Wang JG, Williams JC, Davis BK, Jacobson K, Doerschuk CM, Ting JP, Mackman N. Monocytic microparticles activate endothelial cells in an IL-1β-dependent manner. Blood. 118: 2366-74. PMID 21700772 DOI: 10.1182/Blood-2011-01-330878  0.353
2011 Owens AP, Mackman N. Microparticles in hemostasis and thrombosis. Circulation Research. 108: 1284-97. PMID 21566224 DOI: 10.1161/Circresaha.110.233056  0.405
2011 Antoniak S, Pawlinski R, Mackman N. Protease-activated receptors and myocardial infarction. Iubmb Life. 63: 383-9. PMID 21438116 DOI: 10.1002/Iub.441  0.319
2011 Rondina MT, Schwertz H, Harris ES, Kraemer BF, Campbell RA, Mackman N, Grissom CK, Weyrich AS, Zimmerman GA. The septic milieu triggers expression of spliced tissue factor mRNA in human platelets. Journal of Thrombosis and Haemostasis : Jth. 9: 748-58. PMID 21255247 DOI: 10.1111/J.1538-7836.2011.04208.X  0.386
2011 Luyendyk JP, Flanagan KC, Williams CD, Jaeschke H, Slusser JG, Mackman N, Cantor GH. Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice. Toxicology and Applied Pharmacology. 250: 256-62. PMID 21070799 DOI: 10.1016/J.Taap.2010.11.002  0.444
2011 Luyendyk JP, Mackman N, Sullivan BP. Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 119: 233-43. PMID 20974703 DOI: 10.1093/Toxsci/Kfq327  0.367
2011 Manly DA, Boles J, Mackman N. Role of Tissue Factor in Venous Thrombosis Annual Review of Physiology. 73: 515-525. PMID 20690821 DOI: 10.1146/Annurev-Physiol-042210-121137  0.386
2011 Mackman N. Role of Microparticles in Hemostasis and Thrombosis Blood. 118. DOI: 10.1182/Blood.V118.21.Sci-10.Sci-10  0.433
2010 Key NS, Mackman N. Tissue factor and its measurement in whole blood, plasma, and microparticles. Seminars in Thrombosis and Hemostasis. 36: 865-75. PMID 21049387 DOI: 10.1055/S-0030-1267040  0.407
2010 Kasthuri RS, Glover SL, Boles J, Mackman N. Tissue factor and tissue factor pathway inhibitor as key regulators of global hemostasis: measurement of their levels in coagulation assays. Seminars in Thrombosis and Hemostasis. 36: 764-71. PMID 20978997 DOI: 10.1055/S-0030-1265293  0.409
2010 McEachron TA, Pawlinski R, Richards KL, Church FC, Mackman N. Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis. Blood. 116: 5037-44. PMID 20736455 DOI: 10.1182/Blood-2010-06-293126  0.396
2010 Antoniak S, Rojas M, Spring D, Bullard TA, Verrier ED, Blaxall BC, Mackman N, Pawlinski R. Protease-activated receptor 2 deficiency reduces cardiac ischemia/reperfusion injury. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 2136-42. PMID 20724699 DOI: 10.1161/Atvbaha.110.213280  0.306
2010 Li F, Wang CH, Wang JG, Thai T, Boysen G, Xu L, Turner AL, Wolberg AS, Mackman N, Maeda N, Takahashi N. Elevated tissue factor expression contributes to exacerbated diabetic nephropathy in mice lacking eNOS fed a high fat diet. Journal of Thrombosis and Haemostasis : Jth. 8: 2122-32. PMID 20626618 DOI: 10.1111/J.1538-7836.2010.03976.X  0.309
2010 Owens AP, Mackman N. Tissue factor and thrombosis: The clot starts here. Thrombosis and Haemostasis. 104: 432-439. PMID 20539911 DOI: 10.1160/Th09-11-0771  0.367
2010 Pawlinski R, Wang JG, Owens AP, Williams J, Antoniak S, Tencati M, Luther T, Rowley JW, Low EN, Weyrich AS, Mackman N. Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. Blood. 116: 806-14. PMID 20410508 DOI: 10.1182/Blood-2009-12-259267  0.449
2010 Boles J, Mackman N. Role of tissue factor in thrombosis in antiphospholipid antibody syndrome. Lupus. 19: 370-378. PMID 20353972 DOI: 10.1177/0961203309360810  0.354
2010 Mackman N, Gruber A. Platelet polyphosphate: an endogenous activator of coagulation factor XII Journal of Thrombosis and Haemostasis. 8: 865-867. PMID 20230417 DOI: 10.1111/J.1538-7836.2010.03832.X  0.413
2010 Pawlinski R, Mackman N. Cellular sources of tissue factor in endotoxemia and sepsis. Thrombosis Research. 125. PMID 20185165 DOI: 10.1016/J.Thromres.2010.01.042  0.402
2010 Monroe DM, Mackman N, Hoffman M. Wound healing in hemophilia B mice and low tissue factor mice Thrombosis Research. 125. PMID 20170942 DOI: 10.1016/J.Thromres.2010.01.043  0.345
2010 Rao LVM, Mackman N. Factor VIIa and tissue factor – from cell biology to animal models Thrombosis Research. 125. PMID 20153022 DOI: 10.1016/J.Thromres.2010.01.020  0.43
2010 Mackman N, Becker RC. DVT: A New Era in Anticoagulant Therapy Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 369-371. PMID 20139354 DOI: 10.1161/Atvbaha.110.203497  0.315
2010 Nagai M, Yilmaz CE, Kirchhofer D, Esmon CT, Mackman N, Granger DN. Role of coagulation factors in cerebral venous sinus and cerebral microvascular thrombosis. Neurosurgery. 66: 560-5; discussion 56. PMID 20124931 DOI: 10.1227/01.Neu.0000365745.49583.Fd  0.39
2010 Jenkins EO, Schiff D, Mackman N, Key NS. Venous thromboembolism in malignant gliomas Journal of Thrombosis and Haemostasis. 8: 221-227. PMID 19912518 DOI: 10.1111/J.1538-7836.2009.03690.X  0.307
2010 Manly DA, Wang J, Glover SL, Kasthuri R, Liebman HA, Key NS, Mackman N. Increased microparticle tissue factor activity in cancer patients with Venous Thromboembolism. Thrombosis Research. 125: 511-2. PMID 19854471 DOI: 10.1016/J.Thromres.2009.09.019  0.345
2010 Ollivier V, Wang J, Manly D, Machlus KR, Wolberg AS, Jandrot-Perrus M, Mackman N. Detection of endogenous tissue factor levels in plasma using the calibrated automated thrombogram assay. Thrombosis Research. 125: 90-6. PMID 19345399 DOI: 10.1016/J.Thromres.2009.03.003  0.302
2010 Bharthuar A, Khorana AA, Hutson A, Wang J, Mackman N, Iyer RV. Association of elevated tissue factor (TF) with survival and thromboembolism (TE) in pancreaticobiliary cancers (PBC). Journal of Clinical Oncology. 28: 4126-4126. DOI: 10.1200/Jco.2010.28.15_Suppl.4126  0.307
2010 McEachron T, Church F, Mackman N. Abstract 1251: Increased expression of the plasminogen activator system due to differential protease-activated receptor signaling in breast cancer cells Cancer Research. 70: 1251-1251. DOI: 10.1158/1538-7445.Am10-1251  0.386
2010 Boles J, Barcel D, Owens AP, Glover S, Kasthuri R, Key N, Mackman N. PO-55 Treatment of the monocytic leukemia cell line THP-1 with anthracyclines increases cellular tissue factor activity and release of tissue factor positive microparticles Thrombosis Research. 125. DOI: 10.1016/S0049-3848(10)70105-5  0.38
2010 Wang J-, Yeh J-, Mackman N. PO-49 Tumors are the major source of tissue factor-positive microparticles in a mouse model of pancreatic cancer Thrombosis Research. 125. DOI: 10.1016/S0049-3848(10)70099-2  0.33
2009 Kasthuri RS, Taubman MB, Mackman N. Role of tissue factor in cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 4834-8. PMID 19738116 DOI: 10.1200/Jco.2009.22.6324  0.381
2009 Mceachron T, Mackman N. Tumors, ticks and tissue factor. Journal of Thrombosis and Haemostasis. 7: 1852-1854. PMID 19694942 DOI: 10.1111/J.1538-7836.2009.03592.X  0.403
2009 Mackman N. The many faces of tissue factor Journal of Thrombosis and Haemostasis. 7: 136-139. PMID 19630786 DOI: 10.1111/J.1538-7836.2009.03368.X  0.435
2009 Seshan SV, Franzke CW, Redecha P, Monestier M, Mackman N, Girardi G. Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies. Blood. 114: 1675-83. PMID 19535796 DOI: 10.1182/Blood-2009-01-199117  0.341
2009 Raetzsch CF, Brooks NL, Alderman JM, Moore KS, Hosick PA, Klebanov S, Akira S, Bear JE, Baldwin AS, Mackman N, Combs TP. Lipopolysaccharide inhibition of glucose production through the Toll-like receptor-4, myeloid differentiation factor 88, and nuclear factor kappa b pathway. Hepatology (Baltimore, Md.). 50: 592-600. PMID 19492426 DOI: 10.1002/Hep.22999  0.303
2009 Baker AK, Wang R, Mackman N, Luyendyk JP. Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-alpha expression in macrophages by reducing IL-10 expression. Molecular Immunology. 46: 2249-55. PMID 19447494 DOI: 10.1016/J.Molimm.2009.04.011  0.338
2009 Wang JG, Manly D, Kirchhofer D, Pawlinski R, Mackman N. Levels of microparticle tissue factor activity correlate with coagulation activation in endotoxemic mice. Journal of Thrombosis and Haemostasis. 7: 1092-1098. PMID 19422446 DOI: 10.1111/J.1538-7836.2009.03448.X  0.423
2009 Mackman N. The role of tissue factor and factor VIIa in hemostasis. Anesthesia & Analgesia. 108: 1447-1452. PMID 19372318 DOI: 10.1213/Ane.0B013E31819Bceb1  0.395
2009 Rong Y, Belozerov VE, Tucker-Burden C, Chen G, Durden DL, Olson JJ, Van Meir EG, Mackman N, Brat DJ. Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity. Cancer Research. 69: 2540-9. PMID 19276385 DOI: 10.1158/0008-5472.Can-08-1547  0.408
2009 Luyendyk JP, Cantor GH, Kirchhofer D, Mackman N, Copple BL, Wang R. Tissue factor-dependent coagulation contributes to α- naphthylisothiocyanate-induced cholestatic liver injury in mice American Journal of Physiology-Gastrointestinal and Liver Physiology. 296. PMID 19179621 DOI: 10.1152/Ajpgi.90639.2008  0.359
2009 Mackman N. Thrombosis & Hemostasis: Bleeding hearts Blood. 113: 500. PMID 19147791 DOI: 10.1182/Blood-2008-11-188508  0.439
2009 Li YD, Ye BQ, Zheng SX, Wang JT, Wang JG, Chen M, Liu JG, Pei XH, Wang LJ, Lin ZX, Gupta K, Mackman N, Slungaard A, Key NS, Geng JG. NF-kappaB transcription factor p50 critically regulates tissue factor in deep vein thrombosis. The Journal of Biological Chemistry. 284: 4473-83. PMID 19095643 DOI: 10.1074/Jbc.M806010200  0.377
2009 Wang L, Miller C, Swarthout RF, Rao M, Mackman N, Taubman MB. Vascular smooth muscle-derived tissue factor is critical for arterial thrombosis after ferric chloride-induced injury. Blood. 113: 705-13. PMID 18931346 DOI: 10.1182/Blood-2007-05-090944  0.404
2009 Brittain JE, Manly D, Parise LV, Mackman N, Ataga KI. A Novel Connection Between Stress Erythropoiesis and Coagulation Activation in Sickle Cell Disease. Blood. 114: 905-905. DOI: 10.1182/Blood.V114.22.905.905  0.365
2009 Chen V, Merrill-Skoloff G, Wang L, Chen S, Mackman N, Taubman M, Furie B, Furie B. Intravascular but Not Extravascular Tissue Factor Is Required for Fibrin Generation During Thrombus Formation in Cremaster Arterioles in Living Mice Subjected to Laser Injury. Blood. 114: 332-332. DOI: 10.1182/Blood.V114.22.332.332  0.412
2009 Wang J, Mackman N. Tumors Are a Major Source of Tissue Factor-Positive Microparticles in a Mouse Model. Blood. 114: 3190-3190. DOI: 10.1182/Blood.V114.22.3190.3190  0.336
2009 Glover S, Key NS, Arepally GM, Mackman N, Kasthuri RS. Characterization of Receptors Involved in Heparin Antibody Complex Mediated Induction of Tissue Factor Expression in Monocytes. Blood. 114: 224-224. DOI: 10.1182/Blood.V114.22.224.224  0.351
2009 Spronk HMH, Wilhelm S, Van Oerle R, Knetsch ML, Gailani D, Pawlinski R, Mackman N, Cate Ht, Renné T. Feedback Activation of Factor XI by Thrombin Is Essential for Hemostasis In Vivo. Blood. 114: 2127-2127. DOI: 10.1182/Blood.V114.22.2127.2127  0.428
2009 Baker AK, Wang R, Mackman N, Luyendyk JP. mTOR‐dependent IL‐10 expression inhibits LPS induction of tissue factor and cytokines in macrophages. The Faseb Journal. 23. DOI: 10.1096/Fasebj.23.1_Supplement.570.5  0.375
2008 Milsom CC, Yu JL, Mackman N, Micallef J, Anderson GM, Guha A, Rak JW. Tissue factor regulation by epidermal growth factor receptor and epithelial-to-mesenchymal transitions: effect on tumor initiation and angiogenesis. Cancer Research. 68: 10068-76. PMID 19074872 DOI: 10.1158/0008-5472.Can-08-2067  0.398
2008 Girardi G, Mackman N. Tissue factor in antiphospholipid antibody-induced pregnancy loss: a pro-inflammatory molecule. Lupus. 17: 931-936. PMID 18827058 DOI: 10.1177/0961203308094994  0.377
2008 Redecha P, Franzke CW, Ruf W, Mackman N, Girardi G. Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome Journal of Clinical Investigation. 118: 3453-3461. PMID 18802482 DOI: 10.1172/Jci36089  0.386
2008 Khorana AA, Francis CW, Menzies KE, Wang JG, Hyrien O, Hathcock J, Mackman N, Taubman MB. Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer. Journal of Thrombosis and Haemostasis : Jth. 6: 1983-5. PMID 18795992 DOI: 10.1111/J.1538-7836.2008.03156.X  0.356
2008 Yu J, May L, Milsom C, Anderson GM, Weitz JI, Luyendyk JP, Broze G, Mackman N, Rak J. Contribution of host-derived tissue factor to tumor neovascularization. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1975-81. PMID 18772494 DOI: 10.1161/Atvbaha.108.175083  0.339
2008 Pawlinski R, Mackman N. Use of Mouse Models to Study the Role of Tissue Factor in Tumor Biology Seminars in Thrombosis and Hemostasis. 34: 182-186. PMID 18645923 DOI: 10.1055/S-2008-1079258  0.348
2008 Kidd LB, Schabbauer GA, Luyendyk JP, Holscher TD, Tilley RE, Tencati M, Mackman N. Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice. The Journal of Pharmacology and Experimental Therapeutics. 326: 348-53. PMID 18445780 DOI: 10.1124/Jpet.108.138891  0.302
2008 Schabbauer G, Luyendyk J, Crozat K, Jiang Z, Mackman N, Bahram S, Georgel P. TLR4/CD14-mediated PI3K activation is an essential component of interferon-dependent VSV resistance in macrophages. Molecular Immunology. 45: 2790-6. PMID 18339426 DOI: 10.1016/J.Molimm.2008.02.001  0.325
2008 Luyendyk JP, Schabbauer GA, Tencati M, Holscher T, Pawlinski R, Mackman N. Genetic Analysis of the Role of the PI3K-Akt Pathway in Lipopolysaccharide-Induced Cytokine and Tissue Factor Gene Expression in Monocytes/Macrophages Journal of Immunology. 180: 4218-4226. PMID 18322234 DOI: 10.4049/Jimmunol.180.6.4218  0.386
2008 Reinhardt C, Brühl MLV, Manukyan D, Grahl L, Lorenz M, Altmann B, Dlugai S, Hess S, Konrad I, Orschiedt L, Mackman N, Ruddock L, Massberg S, Engelmann B. Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation Journal of Clinical Investigation. 118: 1110-1122. PMID 18274674 DOI: 10.1172/Jci32376  0.402
2008 Tilley RE, Holscher T, Belani R, Nieva J, Mackman N. Tissue factor activity is increased in a combined platelet and microparticle sample from cancer patients Thrombosis Research. 122: 604-609. PMID 18262600 DOI: 10.1016/J.Thromres.2007.12.023  0.359
2008 Bhattacharjee G, Ahamed J, Pawlinski R, Liu C, Mackman N, Ruf W, Edgington TS. Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. Circulation Research. 102: 457-64. PMID 18174463 DOI: 10.1161/Circresaha.107.167759  0.393
2008 Zampolli A, Marchese P, Ruf W, Mackman N, Ruggeri ZM. Contribution of Intrinsic and Extrinsic Coagulation Pathways to Thrombus Formation in the Mouse Carotid Artery. Blood. 112: 1900-1900. DOI: 10.1182/Blood.V112.11.1900.1900  0.369
2007 Milsom C, Yu J, May L, Meehan B, Magnus N, Al-Nedawi K, Luyendyk J, Weitz J, Klement P, Broze G, Mackman N, Rak J. The role of tumor-and host-related tissue factor pools in oncogene-driven tumor progression. Thrombosis Research. 120: S82-91. PMID 18023719 DOI: 10.1016/S0049-3848(07)70135-4  0.384
2007 Kerschen EJ, Fernandez JA, Cooley BC, Yang XV, Sood R, Mosnier LO, Castellino FJ, Mackman N, Griffin JH, Weiler H. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. The Journal of Experimental Medicine. 204: 2439-48. PMID 17893198 DOI: 10.1084/Jem.20070404  0.382
2007 Ghosh M, Wang H, Ai Y, Romeo E, Luyendyk JP, Peters JM, Mackman N, Dey SK, Hla T. COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. The Journal of Experimental Medicine. 204: 2053-61. PMID 17724132 DOI: 10.1084/Jem.20070828  0.425
2007 Pawlinski R, Tencati M, Holscher T, Pedersen B, Voet T, Tilley RE, Marynen P, Mackman N. Role of cardiac myocyte tissue factor in heart hemostasis Journal of Thrombosis and Haemostasis. 5: 1693-1700. PMID 17663739 DOI: 10.1111/J.1538-7836.2007.02649.X  0.339
2007 Ganey PE, Luyendyk JP, Newport SW, Eagle TM, Maddox JF, Mackman N, Roth RA. Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice. Hepatology (Baltimore, Md.). 46: 1177-86. PMID 17654741 DOI: 10.1002/Hep.21779  0.38
2007 Luyendyk JP, Piper JD, Tencati M, Reddy KV, Holscher T, Zhang R, Luchoomun J, Chen X, Min W, Kunsch C, Mackman N. A novel class of antioxidants inhibit LPS induction of tissue factor by selective inhibition of the activation of ASK1 and MAP kinases. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1857-63. PMID 17561491 DOI: 10.1161/Atvbaha.107.143552  0.371
2007 Mackman N, Tilley RE, Key NS. Role of the Extrinsic Pathway of Blood Coagulation in Hemostasis and Thrombosis Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1687-1693. PMID 17556654 DOI: 10.1161/Atvbaha.107.141911  0.312
2007 Redecha P, Tilley R, Tencati M, Salmon JE, Kirchhofer D, Mackman N, Girardi G. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood. 110: 2423-2431. PMID 17536017 DOI: 10.1182/Blood-2007-01-070631  0.347
2007 Shigeoka AA, Holscher TD, King AJ, Hall FW, Kiosses WB, Tobias PS, Mackman N, McKay DB. TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways. Journal of Immunology (Baltimore, Md. : 1950). 178: 6252-8. PMID 17475853 DOI: 10.4049/Jimmunol.178.10.6252  0.331
2007 Davis DR, Wilson K, Sam MJ, Kennedy SE, Mackman N, Charlesworth JA, Erlich JH. The development of cardiac fibrosis in low tissue factor mice is gender-dependent and is associated with differential regulation of urokinase plasminogen activator. Journal of Molecular and Cellular Cardiology. 42: 559-71. PMID 17234207 DOI: 10.1016/J.Yjmcc.2006.11.017  0.367
2007 Mackman N. Alternatively spliced tissue factor - one cut too many? Thrombosis and Haemostasis. 97: 5-8. PMID 17200762 DOI: 10.1160/Th06-11-0670  0.336
2007 Sevastos J, Kennedy SE, Davis DR, Sam M, Peake PW, Charlesworth JA, Mackman N, Erlich JH. Tissue factor deficiency and PAR-1 deficiency are protective against renal ischemia reperfusion injury. Blood. 109: 577-83. PMID 16990608 DOI: 10.1182/Blood-2006-03-008870  0.327
2006 Rak J, Yu JL, Luyendyk J, Mackman N. Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans. Cancer Research. 66: 10643-6. PMID 17108099 DOI: 10.1158/0008-5472.Can-06-2350  0.387
2006 Schwertz H, Tolley ND, Foulks JM, Denis MM, Risenmay BW, Buerke M, Tilley RE, Rondina MT, Harris EM, Kraiss LW, Mackman N, Zimmerman GA, Weyrich AS. Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. The Journal of Experimental Medicine. 203: 2433-40. PMID 17060476 DOI: 10.1084/Jem.20061302  0.395
2006 Rong Y, Hu F, Huang R, Mackman N, Horowitz JM, Jensen RL, Durden DL, Van Meir EG, Brat DJ. Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms. Cancer Research. 66: 7067-74. PMID 16849552 DOI: 10.1158/0008-5472.Can-06-0346  0.412
2006 Mullarky IK, Szaba FM, Winchel CG, Parent MA, Kummer LW, Mackman N, Johnson LL, Smiley ST. In situ assays demonstrate that interferon-gamma suppresses infection-stimulated hepatic fibrin deposition by promoting fibrinolysis. Journal of Thrombosis and Haemostasis : Jth. 4: 1580-7. PMID 16839357 DOI: 10.1111/J.1538-7836.2006.02010.X  0.319
2006 Luyendyk JP, Tilley RE, Mackman N. Genetic susceptibility to thrombosis. Current Atherosclerosis Reports. 8: 193-197. PMID 16640956 DOI: 10.1007/S11883-006-0073-1  0.343
2006 Tilley R, Mackman N. Tissue factor in hemostasis and thrombosis. Seminars in Thrombosis and Hemostasis. 32: 5-10. PMID 16479457 DOI: 10.1055/S-2006-933335  0.397
2006 Mackman N. Role of tissue factor in hemostasis and thrombosis. Blood Cells Molecules and Diseases. 36: 104-107. PMID 16466951 DOI: 10.1016/J.Bcmd.2005.12.008  0.453
2006 Hayashi M, Matsushita T, Mackman N, Ito M, Adachi T, Katsumi A, Yamamoto K, Takeshita K, Kojima T, Saito H, Murohara T, Naoe T. Fatal thrombosis of antithrombin-deficient mice is rescued differently in the heart and liver by intercrossing with low tissue factor mice Journal of Thrombosis and Haemostasis. 4: 177-185. PMID 16409467 DOI: 10.1111/J.1538-7836.2005.01679.X  0.39
2006 Tilley RE, Pedersen B, Pawlinski R, Sato Y, Erlich JH, Shen Y, Day S, Huang Y, Eitzman DT, Boisvert WA, Curtiss LK, Fay WP, Mackman N. Atherosclerosis in mice is not affected by a reduction in tissue factor expression. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 555-62. PMID 16385085 DOI: 10.1161/01.Atv.0000202028.62414.3C  0.34
2006 Geng J, Wang J, Mackman N, Slungaard A, Huo Y, Key NS. Regulation of Tissue Factor by NF-kB Transcription Factor p50 Is Essential for the Pathogeneses of Deep Vein Thrombosis and Arterial Restenosis. Blood. 108: 1458-1458. DOI: 10.1182/Blood.V108.11.1458.1458  0.391
2006 Frank RD, Holscher T, Schabbauer G, Tencati M, Pawlinski R, Weitz JI, Mackman N. A non-anticoagulant synthetic pentasaccharide reduces inflammation in a murine model of kidney ischemia-reperfusion injury Thrombosis and Haemostasis. 96: 802-806. DOI: 10.1160/Th06-07-0418  0.312
2005 Motton DD, Mackman N, Tilley RE, Rutledge JC. Postprandial elevation of tissue factor antigen in the blood of healthy adults. Thrombosis and Haemostasis. 94: 504-9. PMID 16268463 DOI: 10.1160/Th04-12-0826  0.403
2005 Rushworth SA, Chen XL, Mackman N, Ogborne RM, O'Connell MA. Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C. Journal of Immunology (Baltimore, Md. : 1950). 175: 4408-15. PMID 16177082 DOI: 10.4049/Jimmunol.175.7.4408  0.342
2005 Mackman N. Tissue-Specific Hemostasis in Mice Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 2273-2281. PMID 16123318 DOI: 10.1161/01.Atv.0000183884.06371.52  0.445
2005 Kamimura M, Viedt C, Dalpke A, Rosenfeld ME, Mackman N, Cohen DM, Blessing E, Preusch M, Weber CM, Kreuzer J, Katus HA, Bea F. Interleukin-10 suppresses tissue factor expression in lipopolysaccharide-stimulated macrophages via inhibition of Egr-1 and a serum response element/MEK-ERK1/2 pathway. Circulation Research. 97: 305-13. PMID 16037570 DOI: 10.1161/01.Res.0000177893.24574.13  0.327
2005 Bhattacharjee G, Ahamed J, Pedersen B, El-Sheikh A, Mackman N, Ruf W, Liu C, Edgington TS. Regulation of tissue factor--mediated initiation of the coagulation cascade by cell surface grp78. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 1737-43. PMID 15947236 DOI: 10.1161/01.Atv.0000173419.31242.56  0.381
2005 Frank RD, Schabbauer G, Holscher T, Sato Y, Tencati M, Pawlinski R, Mackman N. The synthetic pentasaccharide fondaparinux reduces coagulation, inflammation and neutrophil accumulation in kidney ischemia–reperfusion injury Journal of Thrombosis and Haemostasis. 3: 531-540. PMID 15748244 DOI: 10.1111/J.1538-7836.2005.01188.X  0.326
2005 Pedersen B, Holscher T, Sato Y, Pawlinski RL, Mackman N. A balance between tissue factor and tissue factor pathway inhibitor is required for embryonic development and hemostasis in adult mice Blood. 105: 2777-2782. PMID 15598816 DOI: 10.1182/Blood-2004-09-3724  0.386
2005 Yu JL, May L, Lhotak V, Shahrzad S, Shirasawa S, Weitz JI, Coomber BL, Mackman N, Rak JW. Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. Blood. 105: 1734-41. PMID 15494427 DOI: 10.1182/Blood-2004-05-2042  0.373
2005 Day SM, Reeve JL, Pedersen B, Farris DM, Myers DD, Im M, Wakefield TW, Mackman N, Fay WP. Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall. Blood. 105: 192-8. PMID 15339841 DOI: 10.1182/Blood-2004-06-2225  0.381
2005 Bhattacharjee G, Arandjelovic S, Mackman N, Gonias SL, Edgington TS. Enhancement of Tissue Factor Dependent Procoagulant Activity and Factor Xa Generation by Alpha2-Macroglobulin. Blood. 106: 1941-1941. DOI: 10.1182/Blood.V106.11.1941.1941  0.4
2005 Tilley RE, Holscher T, Belani R, Nieva J, Mackman N. Measurement of Blood-Borne Tissue Factor Procoagulant Activity in Healthy Individuals and Cancer Patients Using a Novel Assay. Blood. 106: 1938-1938. DOI: 10.1182/Blood.V106.11.1938.1938  0.379
2004 Pyo RT, Sato Y, Mackman N, Taubman MB. Mice deficient in tissue factor demonstrate attenuated intimal hyperplasia in response to vascular injury and decreased smooth muscle cell migration. Thrombosis and Haemostasis. 92: 451-8. PMID 15351840 DOI: 10.1160/Th04-02-0122  0.394
2004 Pawlinski R, Pedersen B, Erlich J, Mackman N. Role of tissue factor in haemostasis, thrombosis, angiogenesis and inflammation: lessons from low tissue factor mice. Thrombosis and Haemostasis. 92: 444-450. PMID 15351839 DOI: 10.1160/Th04-05-0309  0.439
2004 Mackman N. Mouse models in haemostasis and thrombosis. Thrombosis and Haemostasis. 92: 440-443. PMID 15351838 DOI: 10.1160/Th04-07-0414  0.346
2004 Pawlinski R, Mackman N. Tissue factor, coagulation proteases, and protease-activated receptors in endotoxemia and sepsis. Critical Care Medicine. 32: S293-7. PMID 15118533 DOI: 10.1097/01.ccm.0000128445.95144.b8  0.362
2004 Mackman N. Role of tissue factor in hemostasis, thrombosis, and vascular development. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 1015-22. PMID 15117736 DOI: 10.1161/01.ATV.0000130465.23430.74  0.356
2004 Pawlinski R, Pedersen B, Tencati M, Mackman N. Generation of Floxed Tissue Factor Mice. Blood. 104: 3976-3976. DOI: 10.1182/Blood.V104.11.3976.3976  0.371
2004 Hillery CA, Foster TD, Holzhauer SL, Scott JP, Panepinto JA, Mohandas N, Mackman N, Wandersee NJ. Tissue Factor Deficiency Decreases Sickle Cell-Induced Vascular Stasis in a Hematopoietic Stem Cell Transplant Model of Murine Sickle Cell Disease. Blood. 104: 236-236. DOI: 10.1182/Blood.V104.11.236.236  0.398
2004 Schabbauer G, Frank RD, Holscher T, Sato Y, Tencati M, Pawlinski R, Mackman N. The Synthetic Pentasaccharide, Fondaparinux, Reduces Inflammation and Neutrophil Accumulation in Kidney Ischemia-Reperfusion Injury. Blood. 104: 217-217. DOI: 10.1182/Blood.V104.11.217.217  0.391
2004 Bhattacharjee G, Ahamed J, Pedersen B, El-Sheikh A, Liu C, Mackman N, Edgington TS. The Effect of Grp78 Inhibition on Tissue Factor Gene Expression, Procoagulant Activity, and Factor Xa Generation. Blood. 104: 1924-1924. DOI: 10.1182/Blood.V104.11.1924.1924  0.414
2003 Mackman N. The role of the tissue factor-thrombin pathway in cardiac ischemia-reperfusion injury. Seminars in Vascular Medicine. 3: 193-198. PMID 15199482 DOI: 10.1055/S-2003-40677  0.342
2003 Tenno T, Öberg F, Mackman N, Nilsson K, Siegbahn A. PML/RARα plays a role for basal activity and retinoid-induced repression of the tissue factor promoter in acute promyelocytic leukemia cells Thrombosis and Haemostasis. 90: 930-939. PMID 14597990 DOI: 10.1160/Th03-02-0087  0.399
2003 Pawlinski R, Pedersen B, Schabbauer G, Tencati M, Holscher T, Boisvert W, Andrade-Gordon P, Frank RD, Mackman N. Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia. Blood. 103: 1342-7. PMID 14576054 DOI: 10.1182/blood-2003-09-3051  0.344
2003 Bea F, Puolakkainen MH, McMillen T, Hudson FN, Mackman N, Kuo CC, Campbell LA, Rosenfeld ME. Chlamydia pneumoniae induces tissue factor expression in mouse macrophages via activation of Egr-1 and the MEK-ERK1/2 pathway. Circulation Research. 92: 394-401. PMID 12600889 DOI: 10.1161/01.Res.0000059982.43865.75  0.396
2001 Melis E, Moons L, Mol MD, Herbert JM, Mackman N, Collen D, Carmeliet P, Dewerchin M. Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development. Biochemical and Biophysical Research Communications. 286: 580-586. PMID 11511099 DOI: 10.1006/Bbrc.2001.5425  0.398
2001 Marx N, Mackman N, Schönbeck U, Yilmaz N, Hombach V, Libby P, Plutzky J. PPARα activators inhibit tissue factor expression and activity in human monocytes Circulation. 103: 213-219. PMID 11208679 DOI: 10.1161/01.Cir.103.2.213  0.423
2000 Muller DN, Mervaala EMA, Dechend R, Fiebeler A, Park JK, Schmidt F, Theuer J, Breu V, Mackman N, Luther T, Schneider W, Gulba D, Ganten D, Haller H, Luft FC. Angiotensin II (AT1) receptor blockade reduces vascular tissue factor in angiotensin II-induced cardiac vasculopathy American Journal of Pathology. 157: 111-122. PMID 10880382 DOI: 10.1016/S0002-9440(10)64523-3  0.37
2000 Mackman N. Lipopolysaccharide induction of gene expression in human monocytic cells. Immunologic Research. 21: 247-251. PMID 10852124 DOI: 10.1385/Ir:21:2-3:247  0.39
2000 Dechend R, Homuth V, Wallukat G, Kreuzer J, Park JK, Theuer J, Juepner A, Gulba DC, Mackman N, Haller H, Luft FC. AT1 Receptor Agonistic Antibodies From Preeclamptic Patients Cause Vascular Cells to Express Tissue Factor Circulation. 101: 2382-2387. PMID 10821814 DOI: 10.1161/01.Cir.101.20.2382  0.383
1999 Xia Y, Chen S, Wang Y, Mackman N, Ku G, Lo D, Feng L. RelB modulation of IκBα stability as a mechanism of transcription suppression of interleukin-1α (IL-1α), IL-1β, and tumor necrosis factor alpha in fibroblasts Molecular and Cellular Biology. 19: 7688-7696. PMID 10523657 DOI: 10.1128/Mcb.19.11.7688  0.364
1999 Leitinger N, Tyner TR, Oslund L, Rizza C, Subbanagounder G, Lee H, Shih PT, Mackman N, Tigyi G, Territo MC, Berliner JA, Vora DK. Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils Proceedings of the National Academy of Sciences of the United States of America. 96: 12010-12015. PMID 10518567 DOI: 10.1073/Pnas.96.21.12010  0.36
1999 Erlich J, Parry GCN, Fearns C, Muller M, Carmeliet P, Luther T, Mackman N. Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation Proceedings of the National Academy of Sciences of the United States of America. 96: 8138-8143. PMID 10393961 DOI: 10.1073/Pnas.96.14.8138  0.35
1999 Erlich J, Fearns C, Mathison J, Ulevitch RJ, Mackman N. Lipopolysaccharide induction of tissue factor expression in rabbits. Infection and Immunity. 67: 2540-2546. PMID 10225918 DOI: 10.1128/Iai.67.5.2540-2546.1999  0.395
1999 Houston P, Dickson MC, Ludbrook V, White B, Schwachtgen JL, McVey JH, Mackman N, Reese JM, Gorman DG, Campbell C, Braddock M. Fluid Shear Stress Induction of the Tissue Factor Promoter In Vitro and In Vivo Is Mediated by Egr-1 Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 281-289. PMID 9974408 DOI: 10.1161/01.Atv.19.2.281  0.344
1998 Parry GCN, Mackman N. NF-κB mediated transcription in human monocytic cells and endothelial cells Trends in Cardiovascular Medicine. 8: 138-142. PMID 21235924 DOI: 10.1016/S1050-1738(98)00002-4  0.396
1998 O’Connell MA, Bennett BL, Mercurio F, Manning AM, Mackman N. Role of IKK1 and IKK2 in Lipopolysaccharide Signaling in Human Monocytic Cells Journal of Biological Chemistry. 273: 30410-30414. PMID 9804806 DOI: 10.1074/Jbc.273.46.30410  0.366
1998 Bohuslav J, Kravchenko VV, Parry GCN, Erlich JH, Gerondakis S, Mackman N, Ulevitch RJ. Regulation of an essential innate immune response by the p50 subunit of NF-kappaB. Journal of Clinical Investigation. 102: 1645-1652. PMID 9802878 DOI: 10.1172/Jci3877  0.339
1998 Yan SF, Zou YS, Gao Y, Zhai C, Mackman N, Lee SL, Milbrandt J, Pinsky D, Kisiel W, Stern D. Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia Proceedings of the National Academy of Sciences of the United States of America. 95: 8298-8303. PMID 9653181 DOI: 10.1073/Pnas.95.14.8298  0.437
1998 Krikun G, Schatz F, Mackman N, Guller S, Lockwood CJ. Transcriptional regulation of the tissue factor gene by progestins in human endometrial stromal cells. The Journal of Clinical Endocrinology and Metabolism. 83: 926-930. PMID 9506750 DOI: 10.1210/Jcem.83.3.4616  0.356
1998 Parry GCN, Erlich JH, Carmeliet P, Luther T, Mackman N. Low levels of tissue factor are compatible with development and hemostasis in mice. Journal of Clinical Investigation. 101: 560-569. PMID 9449688 DOI: 10.1172/Jci814  0.41
1998 Oeth P, Yao J, Fan ST, Mackman N. Retinoic Acid Selectively Inhibits Lipopolysaccharide Induction of Tissue Factor Gene Expression in Human Monocytes Blood. 91: 2857-2865. DOI: 10.1182/Blood.V91.8.2857.2857_2857_2865  0.399
1997 Brand K, Eisele T, Kreusel U, Page M, Page S, Haas M, Gerling A, Kaltschmidt C, Neumann FJ, Mackman N, Baeuerle PA, Walli AK, Neumeier D. Dysregulation of monocytic nuclear factor-κB by oxidized low-density lipoprotein Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 1901-1909. PMID 9351352 DOI: 10.1161/01.Atv.17.10.1901  0.353
1997 Yao J, Mackman N, Edgington TS, Fan ST. Lipopolysaccharide Induction of the Tumor Necrosis Factor-α Promoter in Human Monocytic Cells REGULATION BY Egr-1, c-Jun, AND NF-κB TRANSCRIPTION FACTORS Journal of Biological Chemistry. 272: 17795-17801. PMID 9211933 DOI: 10.1074/Jbc.272.28.17795  0.326
1997 Carmeliet P, Moons L, Dewerchin M, Mackman N, Luther T, Breier G, Ploplis V, Müller M, Nagy A, Plow E, Gerard R, Edgington T, Risau W, Collen D. Insights in vessel development and vascular disorders using targeted inactivation and transfer of vascular endothelial growth factor, the tissue factor receptor, and the plasminogen system Annals of the New York Academy of Sciences. 811: 191-206. PMID 9186598 DOI: 10.1111/J.1749-6632.1997.Tb52002.X  0.398
1997 Oeth P, Parry GCN, Mackman N. Regulation of the Tissue Factor Gene in Human Monocytic Cells: Role of AP-1, NF-κB/Rel, and Sp1 Proteins in Uninduced and Lipopolysaccharide-Induced Expression Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 365-374. PMID 9081693 DOI: 10.1161/01.Atv.17.2.365  0.364
1997 Lin MC, Almus-Jacobs F, Chen HH, Parry GC, Mackman N, Shyy JY, Chien S. Shear stress induction of the tissue factor gene. The Journal of Clinical Investigation. 99: 737-44. PMID 9045878 DOI: 10.1172/Jci119219  0.311
1997 Bierhaus A, Zhang Y, Quehenberger P, Luther T, Haase M, Müller M, Mackman N, Ziegler R, Nawroth PP. The dietary pigment curcumin reduces endothelial Tissue Factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-κB Thrombosis and Haemostasis. 77: 772-782. DOI: 10.1055/S-0038-1656049  0.356
1997 Parry GCN, Mackman N. 12 Transcriptional regulation of the human urokinase-type plasminogen activator receptor gene Fibrinolysis and Proteolysis. 11: 4. DOI: 10.1016/S0268-9499(97)80127-0  0.303
1996 Yebra M, Parry GCN, Strömblad S, Mackman N, Rosenberg S, Mueller BM, Cheresh DA. Requirement of receptor-bound urokinase-type plasminogen activator for integrin αvβ5-directed cell migration Journal of Biological Chemistry. 271: 29393-29399. PMID 8910604 DOI: 10.1074/Jbc.271.46.29393  0.363
1996 Mackman N. Regulation of Tissue Factor Gene Expression in Human Monocytic and Endothelial Cells Pathophysiology of Haemostasis and Thrombosis. 26: 17-19. PMID 8904167 DOI: 10.1159/000217234  0.411
1996 Carmeliet P, Mackman N, Moons L, Luther T, Gressens P, Vlaenderen IV, Demunck H, Kasper M, Breier G, Evrard P, Müller M, Risau W, Edgington T, Collen D. Role of tissue factor in embryonic blood vessel development Nature. 383: 73-75. PMID 8779717 DOI: 10.1038/383073A0  0.42
1996 Gonzalez-Dunia D, Eddleston M, Mackman N, Carbone K, Torre JCdl. Expression of tissue factor is increased in astrocytes within the central nervous system during persistent infection with borna disease virus. Journal of Virology. 70: 5812-5820. PMID 8709198 DOI: 10.1128/Jvi.70.9.5812-5820.1996  0.348
1996 Ollivier V, Parry GCN, Cobb RR, Prost Dd, Mackman N. Elevated Cyclic AMP Inhibits NF-κB-mediated Transcription in Human Monocytic Cells and Endothelial Cells Journal of Biological Chemistry. 271: 20828-20835. PMID 8702838 DOI: 10.1074/Jbc.271.34.20828  0.399
1996 Cobb RR, Felts KA, Parry GCN, Mackman N. Proteasome inhibitors block VCAM-1 and ICAM-1 gene expression in endothelial cells without affecting nuclear translocation of nuclear factor-κB European Journal of Immunology. 26: 839-845. PMID 8625976 DOI: 10.1002/Eji.1830260417  0.331
1996 Cobb RR, Felts KA, McKenzie TC, Parry GCN, Mackman N. A benzothiophene-carboxamide is a potent inhibitor of IL-1β induced VCAM-1 gene expression in human endothelial cells Febs Letters. 382: 323-326. PMID 8605994 DOI: 10.1016/0014-5793(96)00202-5  0.328
1996 Cui MZ, Parry GCN, Oeth P, Larson H, Smith M, Huang RP, Adamson ED, Mackman N. Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and EGR-1. Journal of Biological Chemistry. 271: 2731-2739. PMID 8576248 DOI: 10.1074/Jbc.271.5.2731  0.351
1995 Quirk SM, Pentecost BT, Mackman N, Loskutoff DJ, Hartzell S, Henrikson KP. The regulation of uterine tissue factor by estrogen. Endocrine. 3: 177-84. PMID 21153155 DOI: 10.1007/Bf02990070  0.364
1995 Parry GCN, Mackman N. Transcriptional Regulation of Tissue Factor Expression in Human Endothelial Cells Arteriosclerosis, Thrombosis, and Vascular Biology. 15: 612-621. PMID 7749875 DOI: 10.1161/01.Atv.15.5.612  0.392
1995 Bierhaus A, Zhang Y, Deng Y, Mackman N, Quehenberger P, Haase M, Luther T, Muller M, Bohrer H, Greten J, Martin E, Baeuerle PA, Waldherr R, Kisiel W, Ziegler R, et al. Mechanism of the tumor necrosis factor α-mediated induction of endothelial tissue factor Journal of Biological Chemistry. 270: 26419-26432. PMID 7592857 DOI: 10.1074/Jbc.270.44.26419  0.375
1995 Olman MA, Mackman N, Gladson CL, Moser KM, Loskutoff DJ. Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse. The Journal of Clinical Investigation. 96: 1621-30. PMID 7544811 DOI: 10.1172/Jci118201  0.317
1995 Oeth P, Mackman N. Salicylates inhibit lipopolysaccharide-induced transcriptional activation of the tissue factor gene in human monocytic cells Blood. 86: 4144-4152. DOI: 10.1182/Blood.V86.11.4144.Bloodjournal86114144  0.396
1995 Bierhaus A, Hemmer CJ, Mackman N, Kutob RM, Ziegler R, Dietrich M, Nawroth PP. Antiparasitic treatment of patients with P. falciparum malaria reduces the ability of patient serum to induce tissue factor by decreasing NF-κB activation Thrombosis and Haemostasis. 73: 39-48. DOI: 10.1055/S-0038-1653723  0.338
1994 Oeth PA, Parry GCN, Kunsch C, Nantermet P, Rosen CA, Mackman N. Lipopolysaccharide induction of tissue factor gene expression in monocytic cells is mediated by binding of c-Rel/p65 heterodimers to a kappa B-like site. Molecular and Cellular Biology. 14: 3772-3781. PMID 8196620 DOI: 10.1128/Mcb.14.6.3772  0.327
1994 Cui MZ, Parry GCN, Edgington TS, Mackman N. Regulation of tissue factor gene expression in epithelial cells. Induction by serum and phorbol 12-myristate 13-acetate. Arteriosclerosis, Thrombosis, and Vascular Biology. 14: 807-814. PMID 8172857 DOI: 10.1161/01.Atv.14.5.807  0.391
1994 Brand K, Banka CL, Mackman N, Terkeltaub RA, Fan ST, Curtiss LK. Oxidized LDL enhances lipopolysaccharide-induced tissue factor expression in human adherent monocytes. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology / American Heart Association. 14: 790-7. PMID 8172855 DOI: 10.1161/01.Atv.14.5.790  0.393
1994 Steinemann S, Ulevitch RJ, Mackman N. Role of the lipopolysaccharide (LPS)-binding protein/CD14 pathway in LPS induction of tissue factor expression in monocytic cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 14: 1202-1209. PMID 7517185 DOI: 10.1161/01.Atv.14.7.1202  0.354
1993 Eddleston M, de la Torre JC, Oldstone MB, Loskutoff DJ, Edgington TS, Mackman N. Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis. The Journal of Clinical Investigation. 92: 349-58. PMID 8326003 DOI: 10.1172/Jci116573  0.329
1993 Ollivier V, Houssaye S, Ternisien C, Leon A, Verneuil Hd, Elbim C, Mackman N, Edgington T, Prost Dd. Endotoxin-induced tissue factor messenger RNA in human monocytes is negatively regulated by a cyclic AMP-dependent mechanism Blood. 81: 973-979. DOI: 10.1182/Blood.V81.4.973.973  0.384
1993 Eddleston MP, Mackman N, de la Torre JC, Oldstone MB. COAGULATION FACTORS IN THE CNS Journal of Neuropathology and Experimental Neurology. 52: 315. DOI: 10.1097/00005072-199305000-00219  0.321
1992 Mackman N, Imes S, Maske WH, Taylor B, Lusis AJ, Drake TA. Structure of the murine tissue factor gene: Chromosome location and conservation of regulatory elements in the promoter Arteriosclerosis, Thrombosis, and Vascular Biology. 12: 474-483. PMID 1348427 DOI: 10.1161/01.Atv.12.4.474  0.349
1991 Edgington TS, Ruf W, Rehemtulla A, Mackman N. The molecular biology of initiation of coagulation by tissue factor. Current Studies in Hematology and Blood Transfusion. 58: 15-21. PMID 1954763 DOI: 10.1159/000419330  0.353
1991 Brand K, Fowler BJ, Edgington TS, Mackman N. Tissue factor mRNA in THP-1 monocytic cells is regulated at both transcriptional and posttranscriptional levels in response to lipopolysaccharide. Molecular and Cellular Biology. 11: 4732-4738. PMID 1875949 DOI: 10.1128/Mcb.11.9.4732  0.362
1991 Mackman N, Brand K, Edgington TS. Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites. Journal of Experimental Medicine. 174: 1517-1526. PMID 1744583 DOI: 10.1084/Jem.174.6.1517  0.4
1991 Edgington TS, Mackman N, Brand K, Ruf W. The structural biology of expression and function of tissue factor. Thrombosis and Haemostasis. 66: 67-79. DOI: 10.1055/S-0038-1646375  0.341
1990 Mackman N, Fowler BJ, Edgington TS, Morrissey JH. Functional analysis of the human tissue factor promoter and induction by serum. Proceedings of the National Academy of Sciences of the United States of America. 87: 2254-8. PMID 2315317 DOI: 10.1073/Pnas.87.6.2254  0.403
1989 Mackman N, Morrissey JH, Fowler B, Edgington TS. Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade. Biochemistry. 28: 1755-62. PMID 2719931 DOI: 10.1021/Bi00430A050  0.402
1989 Morrissey JH, Edgington TS, Mackman N. Molekularbiologie des Gewebefaktors HäMostaseologie. 9: 151-156. DOI: 10.1055/S-0038-1655263  0.307
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