| Year |
Citation |
Score |
| 2021 |
Cai S, Moutal A, Yu J, Chew LA, Isensee J, Chawla R, Gomez K, Luo S, Zhou Y, Chefdeville A, Madura C, Perez-Miller S, Bellampalli SS, Dorame A, Scott DD, ... ... Khanna M, et al. Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents. Science Translational Medicine. 13: eabh1314. PMID 34757807 DOI: 10.1126/scitranslmed.abh1314 |
0.739 |
|
| 2021 |
Francois-Moutal L, Scott DD, Khanna M. Direct targeting of TDP-43, from small molecules to biologics: the therapeutic landscape. Rsc Chemical Biology. 2: 1158-1166. PMID 34458829 DOI: 10.1039/d1cb00110h |
0.754 |
|
| 2021 |
François-Moutal L, Miranda VG, Mollasalehi N, Gokhale V, Khanna M. Targeting of the Long Noncoding RNA MALAT1. Acs Medicinal Chemistry Letters. 12: 915-921. PMID 34141069 DOI: 10.1021/acsmedchemlett.1c00060 |
0.773 |
|
| 2020 |
Mollasalehi N, Francois-Moutal L, Scott DD, Tello JA, Williams H, Mahoney B, Carlson JM, Dong Y, Li X, Miranda VG, Gokhale V, Wang W, Barmada SJ, Khanna M. An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties. Acs Chemical Biology. PMID 33044808 DOI: 10.1021/acschembio.0c00494 |
0.767 |
|
| 2020 |
François-Moutal L, Perez-Miller S, Scott DD, Miranda VG, Mollasalehi N, Khanna M. Corrigendum: Structural Insights Into TDP-43 and Effects of Post-translational Modifications. Frontiers in Molecular Neuroscience. 13: 45. PMID 32300293 DOI: 10.3389/Fnmol.2020.00045 |
0.719 |
|
| 2020 |
Kump KJ, Miao L, Mady ASA, Ansari NH, Shrestha UK, Yang Y, Pal M, Liao C, Perdih A, Abulwerdi FA, Chinnaswamy K, Meagher JL, Carlson JM, Khanna M, Stuckey JA, et al. Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-Apoptotic Mcl-1 and Bfl-1 Proteins. Journal of Medicinal Chemistry. PMID 31971799 DOI: 10.1021/Acs.Jmedchem.9B01442 |
0.352 |
|
| 2020 |
Kump KJ, Miao L, Mady AA, Ansari NH, Shrestha UK, Yang Y, Pal M, Liao C, Perdih A, Abulwerdi FA, Chinnaswamy K, Meagher JL, Carlson JM, Khanna M, Stuckey JA, et al. Abstract LB-226: Discovery of small molecule Mcl-1 and Bfl-1 inhibitors Cancer Research. 80. DOI: 10.1158/1538-7445.Am2020-Lb-226 |
0.357 |
|
| 2019 |
François-Moutal L, Perez-Miller S, Scott DD, Miranda VG, Mollasalehi N, Khanna M. Structural Insights Into TDP-43 and Effects of Post-translational Modifications. Frontiers in Molecular Neuroscience. 12: 301. PMID 31920533 DOI: 10.3389/Fnmol.2019.00301 |
0.753 |
|
| 2019 |
Zhou Y, Cai S, Moutal A, Yu J, Gomez K, Madura CL, Shan Z, Ngan Pham NY, Serafini MJ, Dorame A, Scott DD, Francois-Moutal L, Perez-Miller S, Patek M, Khanna M, et al. The natural flavonoid Naringenin elicits analgesia through inhibition of NaV1.8 voltage-gated sodium channels. Acs Chemical Neuroscience. PMID 31697467 DOI: 10.1021/Acschemneuro.9B00547 |
0.749 |
|
| 2019 |
Moutal A, Shan Z, Miranda VG, François-Moutal L, Madura CL, Khanna M, Khanna R. Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief. Channels (Austin, Tex.). 13: 498-504. PMID 31680630 DOI: 10.1080/19336950.2019.1684608 |
0.745 |
|
| 2019 |
Francois-Moutal L, Scott DD, Felemban R, Miranda VG, Sayegh MR, Perez-Miller S, Khanna R, Gokhale V, Zarnescu DC, Khanna M. A small molecule targeting TDP-43's RNA recognition motifs reduces locomotor defects in a Drosophila model of ALS. Acs Chemical Biology. PMID 31241884 DOI: 10.1021/Acschembio.9B00481 |
0.76 |
|
| 2019 |
Khanna R, Yu J, Yang X, Moutal A, Chefdeville A, Gokhale V, Shuja Z, Chew LA, Bellampalli SS, Luo S, François-Moutal L, Serafini MJ, Ha T, Perez-Miller S, Park KD, ... ... Khanna M, et al. Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy. Pain. PMID 30933958 DOI: 10.1097/J.Pain.0000000000001524 |
0.749 |
|
| 2019 |
Scott DD, Francois-Moutal L, Kumirov VK, Khanna M. H, N and C backbone assignment of apo TDP-43 RNA recognition motifs. Biomolecular Nmr Assignments. PMID 30694439 DOI: 10.1007/S12104-018-09870-X |
0.79 |
|
| 2018 |
Cai S, Bellampalli SS, Yu J, Li W, Ji Y, Wijeratne EMK, Dorame A, Luo S, Shan Z, Khanna M, Moutal A, Streicher JM, Gunatilaka AAL, Khanna R. (-)-Hardwickiic acid and Hautriwaic acid induce antinociception via blockade of tetrodotoxin-sensitive voltage-dependent sodium channels. Acs Chemical Neuroscience. PMID 30525440 DOI: 10.1021/Acschemneuro.8B00617 |
0.361 |
|
| 2018 |
Bellampalli SS, Ji Y, Moutal A, Cai S, Wijeratne EMK, Gandini MA, Yu J, Chefdeville A, Dorame A, Chew LA, Madura CL, Luo S, Molnar G, Khanna M, Streicher JM, et al. Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels. Pain. PMID 30169422 DOI: 10.1097/J.Pain.0000000000001385 |
0.356 |
|
| 2018 |
Francois-Moutal L, Jahanbakhsh S, Nelson A, Ray D, Scott DD, Hennefarth M, Moutal A, Perez-Miller S, Ambrose AJ, Al-Shamari A, Coursodon P, Meechoovet B, Reiman R, Lyons E, Beilstein M, ... ... Khanna M, et al. A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B). Acs Chemical Biology. PMID 30141626 DOI: 10.1021/Acschembio.8B00745 |
0.784 |
|
| 2018 |
François-Moutal L, Scott DD, Perez-Miller S, Gokhale V, Khanna M, Khanna R. Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels. Channels (Austin, Tex.). 1-9. PMID 30081699 DOI: 10.1080/19336950.2018.1491244 |
0.766 |
|
| 2018 |
François-Moutal L, Dustrude ET, Wang Y, Brustovetsky T, Dorame A, Ju W, Moutal A, Perez-Miller S, Brustovetsky N, Gokhale V, Khanna M, Khanna R. Inhibition of the Ubc9 E2 SUMO conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain. Pain. PMID 29847471 DOI: 10.1097/J.Pain.0000000000001294 |
0.748 |
|
| 2018 |
Scott D, Kumirov V, Francois-Moutal L, Khanna M. 1H, 15N and 13C backbone assignment of apoTDP-43 RNA Recognition Motifs Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr27613 |
0.722 |
|
| 2017 |
Moutal A, Yang X, Li W, Gilbraith KB, Luo S, Cai S, François-Moutal L, Chew LA, Yeon SK, Bellampalli SS, Qu C, Xie JY, Ibrahim MM, Khanna M, Park KD, et al. CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide. Pain. PMID 28809766 DOI: 10.1097/J.Pain.0000000000001002 |
0.736 |
|
| 2017 |
Dustrude ET, Perez-Miller S, François-Moutal L, Moutal A, Khanna M, Khanna R. A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function. Channels (Austin, Tex.). 0. PMID 28277940 DOI: 10.1080/19336950.2017.1299838 |
0.722 |
|
| 2017 |
Moutal A, Li W, Wang Y, Ju W, Luo S, Cai S, François-Moutal L, Perez-Miller S, Hu J, Dustrude ET, Vanderah TW, Gokhale V, Khanna M, Khanna R. Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of CRMP2-derived peptides. British Journal of Pharmacology. PMID 28161890 DOI: 10.1111/Bph.13737 |
0.739 |
|
| 2016 |
Dustrude ET, Moutal A, Yang X, Wang Y, Khanna M, Khanna R. Hierarchical CRMP2 posttranslational modifications control NaV1.7 function. Proceedings of the National Academy of Sciences of the United States of America. PMID 27940916 DOI: 10.1073/Pnas.1610531113 |
0.392 |
|
| 2016 |
Xie JY, Chew LA, Yang X, Wang Y, Qu C, Wang Y, Federici LM, Fitz SD, Ripsch MS, Due MR, Moutal A, Khanna M, White FA, Vanderah TW, Johnson PL, et al. Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential. Pain. 157: 2124-2140. PMID 27537210 DOI: 10.1097/J.Pain.0000000000000628 |
0.376 |
|
| 2016 |
Moutal A, Chew LA, Yang X, Wang Y, Yeon SK, Telemi E, Meroueh S, Park KD, Shrinivasan R, Gilbraith KB, Qu C, Xie JY, Patwardhan A, Vanderah TW, Khanna M, et al. (S)-Lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology. Pain. PMID 26967696 DOI: 10.1097/J.Pain.0000000000000555 |
0.419 |
|
| 2015 |
Moutal A, François-Moutal L, Perez-Miller S, Cottier K, Chew LA, Yeon SK, Dai J, Park KD, Khanna M, Khanna R. (S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5. Molecular Neurobiology. PMID 25846820 DOI: 10.1007/S12035-015-9141-2 |
0.718 |
|
| 2015 |
François-Moutal L, Wang Y, Moutal A, Cottier KE, Melemedjian OK, Yang X, Wang Y, Ju W, Largent-Milnes TM, Khanna M, Vanderah TW, Khanna R. A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors. Pain. 156: 1247-64. PMID 25782368 DOI: 10.1097/j.pain.0000000000000147 |
0.717 |
|
| 2015 |
Wang Y, Francois-Moutal L, Moutal A, Cottier K, Melemedjian O, Khanna M, Vanderah T, Khanna R. (399) A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses post-operative pain behaviors The Journal of Pain. 16: S75. DOI: 10.1016/J.Jpain.2015.01.318 |
0.312 |
|
| 2014 |
Moutal A, François-Moutal L, Brittain JM, Khanna M, Khanna R. Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides. Frontiers in Cellular Neuroscience. 8: 471. PMID 25674050 DOI: 10.3389/Fncel.2014.00471 |
0.706 |
|
| 2014 |
Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, et al. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 515: 443-7. PMID 25219851 DOI: 10.1038/Nature13713 |
0.379 |
|
| 2014 |
Wilson SM, Moutal A, Melemedjian OK, Wang Y, Ju W, François-Moutal L, Khanna M, Khanna R. The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth. Frontiers in Cellular Neuroscience. 8: 196. PMID 25104922 DOI: 10.3389/Fncel.2014.00196 |
0.721 |
|
| 2013 |
Quach TT, Wilson SM, Rogemond V, Chounlamountri N, Kolattukudy PE, Martinez S, Khanna M, Belin MF, Khanna R, Honnorat J, Duchemin AM. Mapping CRMP3 domains involved in dendrite morphogenesis and voltage-gated calcium channel regulation. Journal of Cell Science. 126: 4262-73. PMID 23868973 DOI: 10.1242/Jcs.131409 |
0.343 |
|
| 2012 |
Piekarz AD, Due MR, Khanna M, Wang B, Ripsch MS, Wang R, Meroueh SO, Vasko MR, White FA, Khanna R. CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy. Molecular Pain. 8: 54. PMID 22828369 DOI: 10.1186/1744-8069-8-54 |
0.351 |
|
| 2012 |
Wang F, Eric Knabe W, Li L, Jo I, Mani T, Roehm H, Oh K, Li J, Khanna M, Meroueh SO. Design, synthesis, biochemical studies, cellular characterization, and structure-based computational studies of small molecules targeting the urokinase receptor. Bioorganic & Medicinal Chemistry. 20: 4760-73. PMID 22771232 DOI: 10.1016/J.Bmc.2012.06.002 |
0.326 |
|
| 2012 |
Ripsch MS, Ballard CJ, Khanna M, Hurley JH, White FA, Khanna R. A PEPTIDE UNCOUPLING CRMP-2 FROM THE PRESYNAPTIC Ca(2+) CHANNEL COMPLEX DEMONSTRATES EFFICACY IN ANIMAL MODELS OF MIGRAINE AND AIDS THERAPY-INDUCED NEUROPATHY. Translational Neuroscience. 3: 1-8. PMID 22662308 DOI: 10.2478/S13380-012-0002-4 |
0.382 |
|
| 2012 |
Theimer CA, Smith NL, Khanna M. NMR studies of protein-RNA interactions. Methods in Molecular Biology (Clifton, N.J.). 831: 197-218. PMID 22167676 DOI: 10.1007/978-1-61779-480-3_12 |
0.408 |
|
| 2011 |
Khanna M, Wang F, Jo I, Knabe WE, Wilson SM, Li L, Bum-Erdene K, Li J, W Sledge G, Khanna R, Meroueh SO. Targeting multiple conformations leads to small molecule inhibitors of the uPAR·uPA protein-protein interaction that block cancer cell invasion. Acs Chemical Biology. 6: 1232-43. PMID 21875078 DOI: 10.1021/Cb200180M |
0.355 |
|
| 2011 |
Wilson SM, Brittain JM, Piekarz AD, Ballard CJ, Ripsch MS, Cummins TR, Hurley JH, Khanna M, Hammes NM, Samuels BC, White FA, Khanna R. Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex. Channels (Austin, Tex.). 5: 449-56. PMID 21829088 DOI: 10.4161/Chan.5.5.17363 |
0.393 |
|
| 2011 |
Brittain JM, Duarte DB, Wilson SM, Zhu W, Ballard C, Johnson PL, Liu N, Xiong W, Ripsch MS, Wang Y, Fehrenbacher JC, Fitz SD, Khanna M, Park CK, Schmutzler BS, et al. Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⺠channel complex. Nature Medicine. 17: 822-9. PMID 21642979 DOI: 10.1038/Nm.2345 |
0.386 |
|
| 2011 |
Li L, Khanna M, Jo I, Wang F, Ashpole NM, Hudmon A, Meroueh SO. Target-specific support vector machine scoring in structure-based virtual screening: computational validation, in vitro testing in kinases, and effects on lung cancer cell proliferation. Journal of Chemical Information and Modeling. 51: 755-9. PMID 21438548 DOI: 10.1021/Ci100490W |
0.316 |
|
| 2011 |
Parajuli B, Kimble-Hill AC, Khanna M, Ivanova Y, Meroueh S, Hurley TD. Discovery of novel regulators of aldehyde dehydrogenase isoenzymes. Chemico-Biological Interactions. 191: 153-8. PMID 21349255 DOI: 10.1016/J.Cbi.2011.02.018 |
0.303 |
|
| 2011 |
Khanna M, Chelladurai B, Gavini A, Li L, Shao M, Courtney D, Turchi JJ, Matei D, Meroueh S. Targeting ovarian tumor cell adhesion mediated by tissue transglutaminase. Molecular Cancer Therapeutics. 10: 626-36. PMID 21330459 DOI: 10.1158/1535-7163.Mct-10-0912 |
0.345 |
|
| 2011 |
Khanna R, Brittain J, Duarte D, Wilson S, Zhu W, Ballard C, Johnson P, Liu N, Xiong W, Ripsch M, Wang Y, Fehrenbacher J, Khanna M, Park C, Brustovetsky N, et al. Suppression of inflammatory and neuropathic pain by uncoupling collapsin response mediator protein 2 (CRMP-2) from the presynaptic calcium channel complex F1000research. 2. DOI: 10.7490/F1000Research.1089589.1 |
0.331 |
|
| 2010 |
Li L, Li J, Khanna M, Jo I, Baird JP, Meroueh SO. Docking Small Molecules to Predicted Off-Targets of the Cancer Drug Erlotinib Leads to Inhibitors of Lung Cancer Cell Proliferation with Suitable In vitro Pharmacokinetic Properties. Acs Medicinal Chemistry Letters. 1: 229-233. PMID 20824148 DOI: 10.1021/Ml100031A |
0.331 |
|
| 2009 |
Khanna M, Van Bakel H, Tang X, Calarco JA, Babak T, Guo G, Emili A, Greenblatt JF, Hughes TR, Krogan NJ, Blencowe BJ. A systematic characterization of Cwc21, the yeast ortholog of the human spliceosomal protein SRm300. Rna (New York, N.Y.). 15: 2174-85. PMID 19789211 DOI: 10.1261/Rna.1790509 |
0.579 |
|
| 2008 |
Zhao R, Kakihara Y, Gribun A, Huen J, Yang G, Khanna M, Costanzo M, Brost RL, Boone C, Hughes TR, Yip CM, Houry WA. Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation. The Journal of Cell Biology. 180: 563-78. PMID 18268103 DOI: 10.1083/Jcb.200709061 |
0.378 |
|
| 2007 |
Blencowe BJ, Khanna M. Molecular biology: RNA in control. Nature. 447: 391-3. PMID 17522667 DOI: 10.1038/447391A |
0.617 |
|
| 2006 |
Khanna M, Wu H, Johansson C, Caizergues-Ferrer M, Feigon J. Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA. Rna (New York, N.Y.). 12: 40-52. PMID 16373493 DOI: 10.1261/Rna.2221606 |
0.697 |
|
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