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Irene A. Chen, Ph.D. - Publications

Affiliations: 
Chemistry University of California, Santa Barbara, Santa Barbara, CA, United States 
 2005 Harvard University, Cambridge, MA, United States 
Area:
Synthetic biology, Systems Biology, Biophysics, Origin of Life, Molecular Evolution, Phage-based Applications, Human Microbiome
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Peng H, Rossetto D, Mansy SS, Jordan MC, Roos KP, Chen IA. Treatment of Wound Infections in a Mouse Model Using Zn-Releasing Phage Bound to Gold Nanorods. Acs Nano. 16: 4756-4774. PMID 35239330 DOI: 10.1021/acsnano.2c00048  0.547
2021 Peng H, Latifi B, Müller S, Lupták A, Chen IA. Self-cleaving ribozymes: substrate specificity and synthetic biology applications. Rsc Chemical Biology. 2: 1370-1383. PMID 34704043 DOI: 10.1039/d0cb00207k  0.622
2021 Lai YC, Liu Z, Chen IA. Encapsulation of ribozymes inside model protocells leads to faster evolutionary adaptation. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34001592 DOI: 10.1073/pnas.2025054118  0.331
2020 Blanco C, Verbanic S, Seelig B, Chen IA. EasyDIVER: A Pipeline for Assembling and Counting High-Throughput Sequencing Data from In Vitro Evolution of Nucleic Acids or Peptides. Journal of Molecular Evolution. PMID 32529275 DOI: 10.1007/S00239-020-09954-0  0.311
2020 Janzen E, Blanco C, Peng H, Kenchel J, Chen IA. Promiscuous Ribozymes and Their Proposed Role in Prebiotic Evolution. Chemical Reviews. PMID 32011135 DOI: 10.1021/Acs.Chemrev.9B00620  0.318
2020 Saha R, Verbanic S, Chen IA. Functional and Templating Ability of Fluorescent RNA Aptamers in Possible Prebiotic Conditions Biophysical Journal. 118: 70a. DOI: 10.1016/J.Bpj.2019.11.557  0.346
2019 Saha R, Chen I. Effect of UV Radiation on Functional and Templating Ability of Fluorescent RNA Aptamers. Chembiochem : a European Journal of Chemical Biology. PMID 31125512 DOI: 10.1002/Cbic.201900261  0.363
2019 Pressman AD, Liu Z, Janzen E, Blanco C, Müller UF, Joyce GF, Pascal R, Chen IA. Mapping a systematic ribozyme fitness landscape reveals a frustrated evolutionary network for self-aminoacylating RNA. Journal of the American Chemical Society. PMID 30912655 DOI: 10.1021/Jacs.8B13298  0.382
2019 Saha R, Chen IA. Cover Feature: Effect of UV Radiation on Fluorescent RNA Aptamers’ Functional and Templating Ability (ChemBioChem 20/2019) Chembiochem. 20: 2530-2530. DOI: 10.1002/Cbic.201900539  0.309
2018 Saha R, Verbanic S, Chen IA. Lipid vesicles chaperone an encapsulated RNA aptamer. Nature Communications. 9: 2313. PMID 29899431 DOI: 10.1038/S41467-018-04783-8  0.435
2018 Blanco C, Bayas M, Yan F, Chen IA. Analysis of Evolutionarily Independent Protein-RNA Complexes Yields a Criterion to Evaluate the Relevance of Prebiotic Scenarios. Current Biology : Cb. PMID 29398222 DOI: 10.1016/J.Cub.2018.01.014  0.402
2017 Pressman A, Moretti JE, Campbell GW, Müller UF, Chen IA. Analysis of in vitro evolution reveals the underlying distribution of catalytic activity among random sequences. Nucleic Acids Research. PMID 28645146 DOI: 10.1093/Nar/Gkx540  0.301
2016 Xulvi-Brunet R, Campbell GW, Rajamani S, Jiménez JI, Chen IA. Computational analysis of fitness landscapes and evolutionary networks from in vitro evolution experiments. Methods (San Diego, Calif.). PMID 27211010 DOI: 10.1016/J.Ymeth.2016.05.012  0.321
2015 Saha R, Chen IA. Origin of Life: Protocells Red in Tooth and Claw. Current Biology : Cb. 25: R1175-7. PMID 26702654 DOI: 10.1016/J.Cub.2015.11.007  0.378
2015 Pressman A, Blanco C, Chen IA. The RNA World as a Model System to Study the Origin of Life. Current Biology : Cb. 25: R953-63. PMID 26439358 DOI: 10.1016/J.Cub.2015.06.016  0.369
2015 Chen IA. Prebiotic chemistry: Replicating towards complexity. Nature Chemistry. 7: 191-2. PMID 25698324 DOI: 10.1038/Nchem.2188  0.328
2014 Athavale SS, Spicer B, Chen IA. Experimental fitness landscapes to understand the molecular evolution of RNA-based life. Current Opinion in Chemical Biology. 22: 35-9. PMID 25270912 DOI: 10.1016/J.Cbpa.2014.09.008  0.36
2013 Ivica NA, Obermayer B, Campbell GW, Rajamani S, Gerland U, Chen IA. The paradox of dual roles in the RNA world: resolving the conflict between stable folding and templating ability. Journal of Molecular Evolution. 77: 55-63. PMID 24078151 DOI: 10.1007/S00239-013-9584-X  0.378
2013 Jiménez JI, Xulvi-Brunet R, Campbell GW, Turk-MacLeod R, Chen IA. Comprehensive experimental fitness landscape and evolutionary network for small RNA. Proceedings of the National Academy of Sciences of the United States of America. 110: 14984-9. PMID 23980164 DOI: 10.1073/Pnas.1307604110  0.365
2013 Bianconi G, Zhao K, Chen IA, Nowak MA. Selection for replicases in protocells. Plos Computational Biology. 9: e1003051. PMID 23671413 DOI: 10.1371/Journal.Pcbi.1003051  0.309
2013 Leconte AM, Dickinson BC, Yang DD, Chen IA, Allen B, Liu DR. A population-based experimental model for protein evolution: Effects of mutation rate and selection stringency on evolutionary outcomes Biochemistry. 52: 1490-1499. PMID 23360105 DOI: 10.1021/Bi3016185  0.322
2013 Leu K, Kervio E, Obermayer B, Turk-MacLeod RM, Yuan C, Luevano JM, Chen E, Gerland U, Richert C, Chen IA. Cascade of reduced speed and accuracy after errors in enzyme-free copying of nucleic acid sequences. Journal of the American Chemical Society. 135: 354-66. PMID 23259600 DOI: 10.1021/Ja3095558  0.373
2012 Vaidya N, Manapat ML, Chen IA, Xulvi-Brunet R, Hayden EJ, Lehman N. Spontaneous network formation among cooperative RNA replicators. Nature. 491: 72-7. PMID 23075853 DOI: 10.1038/Nature11549  0.361
2012 Chen IA, Nowak MA. From prelife to life: how chemical kinetics become evolutionary dynamics. Accounts of Chemical Research. 45: 2088-96. PMID 22335792 DOI: 10.1021/Ar2002683  0.337
2012 Derr J, Manapat ML, Rajamani S, Leu K, Xulvi-Brunet R, Joseph I, Nowak MA, Chen IA. Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences. Nucleic Acids Research. 40: 4711-22. PMID 22319215 DOI: 10.1093/Nar/Gks065  0.393
2011 Leu K, Obermayer B, Rajamani S, Gerland U, Chen IA. The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA. Nucleic Acids Research. 39: 8135-47. PMID 21724606 DOI: 10.1093/Nar/Gkr525  0.349
2010 Chen IA, Schindlinger M. Quadruplet codons: one small step for a ribosome, one giant leap for proteins: an expanded genetic code could address fundamental questions about algorithmic information, biological function, and the origins of life. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 32: 650-4. PMID 20658702 DOI: 10.1002/Bies.201000051  0.326
2010 Chen IA, Walde P. From self-assembled vesicles to protocells. Cold Spring Harbor Perspectives in Biology. 2: a002170. PMID 20519344 DOI: 10.1101/Cshperspect.A002170  0.382
2010 Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA. Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication. Journal of the American Chemical Society. 132: 5880-5. PMID 20359213 DOI: 10.1021/Ja100780P  0.666
2010 Manapat ML, Chen IA, Nowak MA. The basic reproductive ratio of life. Journal of Theoretical Biology. 263: 317-27. PMID 20034501 DOI: 10.1016/J.Jtbi.2009.12.020  0.328
2010 Chen IA. An RNA Whirl Science. 330: 758-758. DOI: 10.1126/Science.1197794  0.328
2006 Chen IA. GE Prize-winning essay. The emergence of cells during the origin of life. Science (New York, N.Y.). 314: 1558-9. PMID 17158315 DOI: 10.1126/Science.1137541  0.413
2006 Chen IA, Hanczyc MM, Sazani PL, Szostak JW. 3 Protocells: Genetic Polymers Inside Membrane Vesicles Cold Spring Harbor Monograph Archive. 43: 57-88. DOI: 10.1101/087969739.43.57  0.563
2005 Fujikawa SM, Chen IA, Szostak JW. Shrink-wrap vesicles Langmuir. 21: 12124-12129. PMID 16342983 DOI: 10.1021/La052590Q  0.632
2005 Chen IA, Salehi-Ashtiani K, Szostak JW. RNA catalysis in model protocell vesicles Journal of the American Chemical Society. 127: 13213-13219. PMID 16173749 DOI: 10.1021/Ja051784P  0.611
2004 Chen IA, Roberts RW, Szostak JW. The emergence of competition between model protocells. Science (New York, N.Y.). 305: 1474-6. PMID 15353806 DOI: 10.1126/Science.1100757  0.676
2004 Chen IA, Szostak JW. A kinetic study of the growth of fatty acid vesicles Biophysical Journal. 87: 988-998. PMID 15298905 DOI: 10.1529/Biophysj.104.039875  0.567
2004 Chen IA, Szostak JW. Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles Proceedings of the National Academy of Sciences of the United States of America. 101: 7965-7970. PMID 15148394 DOI: 10.1073/Pnas.0308045101  0.549
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