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Gerard Manning - Publications

Affiliations: 
1989-1997 Biochemistry Stanford University, Palo Alto, CA 
 2004-2012 Salk Institute for Biological Studies, La Jolla, CA, United States 
 2012- Bioinformatics & Computational Biology Genentech, Inc., San Francisco, CA, United States 
Area:
Bioinformatics, Genomics, Oncology, Evolution
Website:
http://manninglab.org
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61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Petrie EJ, Sandow JJ, Lehmann WIL, Liang LY, Coursier D, Young SN, Kersten WJA, Fitzgibbon C, Samson AL, Jacobsen AV, Lowes KN, Au AE, Jousset Sabroux H, Lalaoui N, Webb AI, ... ... Manning G, et al. Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3. Cell Reports. 28: 3309-3319.e5. PMID 31553902 DOI: 10.1016/j.celrep.2019.08.055  0.46
2017 Chen MJ, Dixon JE, Manning G. Genomics and evolution of protein phosphatases. Science Signaling. 10. PMID 28400531 DOI: 10.1126/Scisignal.Aag1796  0.446
2016 Foster SA, Whalen DM, Özen A, Wongchenko MJ, Yin J, Yen I, Schaefer G, Mayfield JD, Chmielecki J, Stephens PJ, Albacker LA, Yan Y, Song K, Hatzivassiliou G, Eigenbrot C, ... ... Manning G, et al. Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. Cancer Cell. PMID 26996308 DOI: 10.1016/J.Ccell.2016.02.010  0.337
2016 Newton K, Manning G. Necroptosis and Inflammation. Annual Review of Biochemistry. PMID 26865533 DOI: 10.1146/annurev-biochem-060815-014830  0.361
2016 Foster S, Whalen D, Ozen A, Wongchenko M, Yin J, Yen I, Schaefer G, Mayfield J, Chmielecki J, Stephens P, Albacker L, Yan Y, Song K, Hatzivassiliou G, Eigenbrot C, ... ... Manning G, et al. Abstract 4374: Activation mechanism of oncogenic C-helix shifting mutations in BRAF, EGFR, and HER2 Cancer Research. 76: 4374-4374. DOI: 10.1158/1538-7445.Am2016-4374  0.354
2015 Babbitt PC, Bagos PG, Bairoch A, Bateman A, Chatonnet A, Chen MJ, Craik DJ, Finn RD, Gloriam D, Haft DH, Henrissat B, Holliday GL, Isberg V, Kaas Q, Landsman D, ... ... Manning G, et al. Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat. Database : the Journal of Biological Databases and Curation. 2015: bav063. PMID 26284514 DOI: 10.1093/Database/Bav063  0.31
2015 Rudolph J, Aliagas I, Crawford JJ, Mathieu S, Lee W, Chao Q, Dong P, Rouge L, Wang W, Heise C, Murray LJ, La H, Liu Y, Manning G, Diederich F, et al. Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series. Acs Medicinal Chemistry Letters. 6: 711-5. PMID 26101579 DOI: 10.1021/Acsmedchemlett.5B00151  0.358
2015 Holliday GL, Bairoch A, Bagos PG, Chatonnet A, Craik DJ, Finn RD, Henrissat B, Landsman D, Manning G, Nagano N, O'Donovan C, Pruitt KD, Rawlings ND, Saier M, Sowdhamini R, et al. Key challenges for the creation and maintenance of specialist protein resources. Proteins. 83: 1005-13. PMID 25820941 DOI: 10.1002/Prot.24803  0.336
2015 Klijn C, Durinck S, Stawiski EW, Haverty PM, Jiang Z, Liu H, Degenhardt J, Mayba O, Gnad F, Liu J, Pau G, Reeder J, Cao Y, Mukhyala K, Selvaraj SK, ... ... Manning G, et al. A comprehensive transcriptional portrait of human cancer cell lines. Nature Biotechnology. 33: 306-12. PMID 25485619 DOI: 10.1038/Nbt.3080  0.362
2015 Hunter T, Manning G. The eukaryotic protein kinase superfamily and the emergence of receptor tyrosine kinases Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease. 1-15. DOI: 10.1007/978-1-4939-2053-2_1  0.463
2014 Chipman AD, Ferrier DE, Brena C, Qu J, Hughes DS, Schröder R, Torres-Oliva M, Znassi N, Jiang H, Almeida FC, Alonso CR, Apostolou Z, Aqrawi P, Arthur W, Barna JC, ... ... Manning G, et al. The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima. Plos Biology. 12: e1002005. PMID 25423365 DOI: 10.1371/Journal.Pbio.1002005  0.418
2014 Liu J, McCleland M, Stawiski EW, Gnad F, Mayba O, Haverty PM, Durinck S, Chen YJ, Klijn C, Jhunjhunwala S, Lawrence M, Liu H, Wan Y, Chopra V, Yaylaoglu MB, ... ... Manning G, et al. Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer. Nature Communications. 5: 3830. PMID 24807215 DOI: 10.1038/Ncomms4830  0.313
2014 Murphy JM, Zhang Q, Young SN, Reese ML, Bailey FP, Eyers PA, Ungureanu D, Hammaren H, Silvennoinen O, Varghese LN, Chen K, Tripaydonis A, Jura N, Fukuda K, Qin J, ... ... Manning G, et al. A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties. The Biochemical Journal. 457: 323-34. PMID 24107129 DOI: 10.1042/Bj20131174  0.377
2013 Dellas N, Thomas ST, Manning G, Noel JP. Discovery of a metabolic alternative to the classical mevalonate pathway. Elife. 2: e00672. PMID 24327557 DOI: 10.7554/Elife.00672  0.334
2013 Pottekat A, Becker S, Spencer KR, Yates JR, Manning G, Itkin-Ansari P, Balch WE. Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release. Cell Reports. 4: 921-30. PMID 24012759 DOI: 10.1016/J.Celrep.2013.07.050  0.549
2013 Suga H, Chen Z, de Mendoza A, Sebé-Pedrós A, Brown MW, Kramer E, Carr M, Kerner P, Vervoort M, Sánchez-Pons N, Torruella G, Derelle R, Manning G, Lang BF, Russ C, et al. The Capsaspora genome reveals a complex unicellular prehistory of animals. Nature Communications. 4: 2325. PMID 23942320 DOI: 10.1038/Ncomms3325  0.415
2013 Fairclough SR, Chen Z, Kramer E, Zeng Q, Young S, Robertson HM, Begovic E, Richter DJ, Russ C, Westbrook MJ, Manning G, Lang BF, Haas B, Nusbaum C, King N. Premetazoan genome evolution and the regulation of cell differentiation in the choanoflagellate Salpingoeca rosetta. Genome Biology. 14: R15. PMID 23419129 DOI: 10.1186/Gb-2013-14-2-R15  0.421
2013 Teh PG, Chen MJ, Engel JL, Worby CA, Manning G, Dixon JE, Zhang J. Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica. The Journal of Biological Chemistry. 288: 5176-85. PMID 23293031 DOI: 10.1074/Jbc.M112.413617  0.317
2012 Vilchez D, Morantte I, Liu Z, Douglas PM, Merkwirth C, Rodrigues AP, Manning G, Dillin A. RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature. 489: 263-8. PMID 22922647 DOI: 10.1038/Nature11315  0.317
2012 Ishikawa HO, Xu A, Ogura E, Manning G, Irvine KD. The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins. Plos One. 7: e42988. PMID 22900076 DOI: 10.1371/Journal.Pone.0042988  0.411
2012 Ngaki MN, Louie GV, Philippe RN, Manning G, Pojer F, Bowman ME, Li L, Larsen E, Wurtele ES, Noel JP. Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. Nature. 485: 530-3. PMID 22622584 DOI: 10.1038/Nature11009  0.311
2012 Suga H, Dacre M, de Mendoza A, Shalchian-Tabrizi K, Manning G, Ruiz-Trillo I. Genomic survey of premetazoans shows deep conservation of cytoplasmic tyrosine kinases and multiple radiations of receptor tyrosine kinases. Science Signaling. 5: ra35. PMID 22550341 DOI: 10.1126/Scisignal.2002733  0.454
2011 Mattoo S, Durrant E, Chen MJ, Xiao J, Lazar CS, Manning G, Dixon JE, Worby CA. Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities. The Journal of Biological Chemistry. 286: 32834-42. PMID 21795713 DOI: 10.1074/Jbc.M111.227603  0.363
2011 Manning G, Reiner DS, Lauwaet T, Dacre M, Smith A, Zhai Y, Svard S, Gillin FD. The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology. Genome Biology. 12: R66. PMID 21787419 DOI: 10.1186/gb-2011-12-7-r66  0.387
2011 Xiao J, Engel JL, Zhang J, Chen MJ, Manning G, Dixon JE. Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 11860-5. PMID 21730175 DOI: 10.1073/Pnas.1109290108  0.396
2011 de Cárcer G, Manning G, Malumbres M. From Plk1 to Plk5: functional evolution of polo-like kinases. Cell Cycle (Georgetown, Tex.). 10: 2255-62. PMID 21654194 DOI: 10.4161/cc.10.14.16494  0.466
2011 Baranov PV, Wills NM, Barriscale KA, Firth AE, Jud MC, Letsou A, Manning G, Atkins JF. Programmed ribosomal frameshifting in the expression of the regulator of intestinal stem cell proliferation, adenomatous polyposis coli (APC). Rna Biology. 8: 637-47. PMID 21593603 DOI: 10.4161/rna.8.4.15395  0.357
2011 Banks JA, Nishiyama T, Hasebe M, Bowman JL, Gribskov M, dePamphilis C, Albert VA, Aono N, Aoyama T, Ambrose BA, Ashton NW, Axtell MJ, Barker E, Barker MS, Bennetzen JL, ... ... Manning G, et al. The Selaginella genome identifies genetic changes associated with the evolution of vascular plants. Science (New York, N.Y.). 332: 960-3. PMID 21551031 DOI: 10.1126/Science.1203810  0.322
2011 Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, Dillin A. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature. 470: 404-8. PMID 21331044 DOI: 10.1038/Nature09706  0.327
2011 de Cárcer G, Escobar B, Higuero AM, García L, Ansón A, Pérez G, Mollejo M, Manning G, Meléndez B, Abad-Rodríguez J, Malumbres M. Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. Molecular and Cellular Biology. 31: 1225-39. PMID 21245385 DOI: 10.1128/MCB.00607-10  0.435
2010 Manning G, Scheeff E. How the vertebrates were made: selective pruning of a double-duplicated genome. Bmc Biology. 8: 144. PMID 21144066 DOI: 10.1186/1741-7007-8-144  0.735
2010 Srivastava M, Simakov O, Chapman J, Fahey B, Gauthier ME, Mitros T, Richards GS, Conaco C, Dacre M, Hellsten U, Larroux C, Putnam NH, Stanke M, Adamska M, Darling A, ... ... Manning G, et al. The Amphimedon queenslandica genome and the evolution of animal complexity. Nature. 466: 720-6. PMID 20686567 DOI: 10.1038/Nature09201  0.413
2010 Stajich JE, Wilke SK, Ahrén D, Au CH, Birren BW, Borodovsky M, Burns C, Canbäck B, Casselton LA, Cheng CK, Deng J, Dietrich FS, Fargo DC, Farman ML, Gathman AC, ... ... Manning G, et al. Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus). Proceedings of the National Academy of Sciences of the United States of America. 107: 11889-94. PMID 20547848 DOI: 10.1073/Pnas.1003391107  0.401
2010 Walker CB, de la Torre JR, Klotz MG, Urakawa H, Pinel N, Arp DJ, Brochier-Armanet C, Chain PS, Chan PP, Gollabgir A, Hemp J, Hügler M, Karr EA, Könneke M, Shin M, ... ... Manning G, et al. Nitrosopumilus maritimus genome reveals unique mechanisms for nitrification and autotrophy in globally distributed marine crenarchaea. Proceedings of the National Academy of Sciences of the United States of America. 107: 8818-23. PMID 20421470 DOI: 10.1073/Pnas.0913533107  0.335
2010 Scheeff ED, Axelrod HL, Miller MD, Chiu HJ, Deacon AM, Wilson IA, Manning G. Genomics, evolution, and crystal structure of a new family of bacterial spore kinases. Proteins. 78: 1470-82. PMID 20077512 DOI: 10.1002/Prot.22663  0.75
2010 Manning G, Hunter T. Eukaryotic kinomes. genomics and evolution of protein kinases Handbook of Cell Signaling, 2/E. 2: 393-397. DOI: 10.1016/B978-0-12-374145-5.00056-5  0.519
2009 Nathanson JL, Jappelli R, Scheeff ED, Manning G, Obata K, Brenner S, Callaway EM. Short Promoters in Viral Vectors Drive Selective Expression in Mammalian Inhibitory Neurons, but do not Restrict Activity to Specific Inhibitory Cell-Types. Frontiers in Neural Circuits. 3: 19. PMID 19949461 DOI: 10.3389/Neuro.04.019.2009  0.723
2009 Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ. Cyclin-dependent kinases: a family portrait. Nature Cell Biology. 11: 1275-6. PMID 19884882 DOI: 10.1038/Ncb1109-1275  0.596
2009 Zhang YW, Brognard J, Coughlin C, You Z, Dolled-Filhart M, Aslanian A, Manning G, Abraham RT, Hunter T. The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Molecular Cell. 35: 442-53. PMID 19716789 DOI: 10.1016/J.Molcel.2009.06.030  0.496
2009 Copp J, Manning G, Hunter T. TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Research. 69: 1821-7. PMID 19244117 DOI: 10.1158/0008-5472.Can-08-3014  0.511
2009 Scheeff ED, Eswaran J, Bunkoczi G, Knapp S, Manning G. Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site. Structure (London, England : 1993). 17: 128-38. PMID 19141289 DOI: 10.1016/J.Str.2008.10.018  0.737
2008 Manning G, Young SL, Miller WT, Zhai Y. The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan. Proceedings of the National Academy of Sciences of the United States of America. 105: 9674-9. PMID 18621719 DOI: 10.1073/pnas.0801314105  0.396
2008 King N, Westbrook MJ, Young SL, Kuo A, Abedin M, Chapman J, Fairclough S, Hellsten U, Isogai Y, Letunic I, Marr M, Pincus D, Putnam N, Rokas A, Wright KJ, ... ... Manning G, et al. The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature. 451: 783-8. PMID 18273011 DOI: 10.1038/Nature06617  0.403
2007 Perrin MH, Grace CR, Digruccio MR, Fischer WH, Maji SK, Cantle JP, Smith S, Manning G, Vale WW, Riek R. Distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin-releasing factor and related G-protein-coupled receptors. The Journal of Biological Chemistry. 282: 37529-36. PMID 17940290 DOI: 10.1074/Jbc.M703748200  0.314
2007 Morrison HG, McArthur AG, Gillin FD, Aley SB, Adam RD, Olsen GJ, Best AA, Cande WZ, Chen F, Cipriano MJ, Davids BJ, Dawson SC, Elmendorf HG, Hehl AB, Holder ME, ... ... Manning G, et al. Genomic minimalism in the early diverging intestinal parasite Giardia lamblia. Science (New York, N.Y.). 317: 1921-6. PMID 17901334 DOI: 10.1126/Science.1143837  0.442
2007 Kannan N, Taylor SS, Zhai Y, Venter JC, Manning G. Structural and functional diversity of the microbial kinome. Plos Biology. 5: e17. PMID 17355172 DOI: 10.1371/Journal.Pbio.0050017  0.445
2007 Yooseph S, Sutton G, Rusch DB, Halpern AL, Williamson SJ, Remington K, Eisen JA, Heidelberg KB, Manning G, Li W, Jaroszewski L, Cieplak P, Miller CS, Li H, Mashiyama ST, et al. The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. Plos Biology. 5: e16. PMID 17355171 DOI: 10.1371/Journal.Pbio.0050016  0.395
2006 Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, ... ... Manning G, et al. The genome of the sea urchin Strongylocentrotus purpuratus. Science (New York, N.Y.). 314: 941-52. PMID 17095691 DOI: 10.1126/Science.1133609  0.364
2006 Bradham CA, Foltz KR, Beane WS, Arnone MI, Rizzo F, Coffman JA, Mushegian A, Goel M, Morales J, Geneviere AM, Lapraz F, Robertson AJ, Kelkar H, Loza-Coll M, Townley IK, ... ... Manning G, et al. The sea urchin kinome: a first look. Developmental Biology. 300: 180-93. PMID 17027740 DOI: 10.1016/J.Ydbio.2006.08.074  0.447
2006 Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, ... ... Manning G, et al. Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. Plos Biology. 4: e286. PMID 16933976 DOI: 10.1371/Journal.Pbio.0040286  0.413
2006 Wloga D, Camba A, Rogowski K, Manning G, Jerka-Dziadosz M, Gaertig J. Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms. Molecular Biology of the Cell. 17: 2799-810. PMID 16611747 DOI: 10.1091/Mbc.E05-05-0450  0.459
2006 Goldberg JM, Manning G, Liu A, Fey P, Pilcher KE, Xu Y, Smith JL. The dictyostelium kinome--analysis of the protein kinases from a simple model organism. Plos Genetics. 2: e38. PMID 16596165 DOI: 10.1371/journal.pgen.0020038  0.432
2005 Manning G. Genomic overview of protein kinases. Wormbook : the Online Review of C. Elegans Biology. 1-19. PMID 18050405 DOI: 10.1895/wormbook.1.60.1  0.474
2004 Caenepeel S, Charydczak G, Sudarsanam S, Hunter T, Manning G. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Proceedings of the National Academy of Sciences of the United States of America. 101: 11707-12. PMID 15289607 DOI: 10.1073/Pnas.0306880101  0.573
2003 Wright JH, Wang X, Manning G, LaMere BJ, Le P, Zhu S, Khatry D, Flanagan PM, Buckley SD, Whyte DB, Howlett AR, Bischoff JR, Lipson KE, Jallal B. The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. Molecular and Cellular Biology. 23: 2068-82. PMID 12612079 DOI: 10.1128/MCB.23.6.2068-2082.2003  0.417
2003 Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science (New York, N.Y.). 298: 1912-34. PMID 12471243 DOI: 10.1126/Science.1075762  0.6
2003 Hunter T, Manning G. Eukaryotic Kinomes: Genomic Cataloguing of Protein Kinases and Their Evolution Handbook of Cell Signaling. 1: 373-377. DOI: 10.1016/B978-012124546-7/50427-7  0.519
2002 Manning G, Plowman GD, Hunter T, Sudarsanam S. Evolution of protein kinase signaling from yeast to man. Trends in Biochemical Sciences. 27: 514-20. PMID 12368087 DOI: 10.1016/S0968-0004(02)02179-5  0.573
1996 Samakovlis C, Manning G, Steneberg P, Hacohen N, Cantera R, Krasnow MA. Genetic control of epithelial tube fusion during Drosophila tracheal development. Development (Cambridge, England). 122: 3531-6. PMID 8951068  0.543
1996 Samakovlis C, Hacohen N, Manning G, Sutherland DC, Guillemin K, Krasnow MA. Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events. Development (Cambridge, England). 122: 1395-407. PMID 8625828  0.538
1991 Krasnow MA, Cumberledge S, Manning G, Herzenberg LA, Nolan GP. Whole animal cell sorting of Drosophila embryos. Science (New York, N.Y.). 251: 81-5. PMID 1898782 DOI: 10.1126/Science.1898782  0.554
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