| Year |
Citation |
Score |
| 2019 |
Peiris MN, Meyer AN, Nelson KN, Bisom-Rapp EW, Donoghue DJ. Oncogenic fusion protein BCR-FGFR1 requires BCR-mediated oligomerization and chaperonin Hsp90 for activation. Haematologica. PMID 31439673 DOI: 10.3324/Haematol.2019.220871 |
0.318 |
|
| 2019 |
Peiris MN, Li F, Donoghue DJ. BCR: a promiscuous fusion partner in hematopoietic disorders. Oncotarget. 10: 2738-2754. PMID 31105873 DOI: 10.18632/Oncotarget.26837 |
0.321 |
|
| 2018 |
Nelson KN, Meyer AN, Wang CG, Donoghue DJ. Oncogenic driver FGFR3-TACC3 is dependent on membrane trafficking and ERK signaling. Oncotarget. 9: 34306-34319. PMID 30344944 DOI: 10.18632/Oncotarget.26142 |
0.341 |
|
| 2018 |
Meyer AN, Gallo LH, Ko J, Cardenas G, Nelson KN, Siari A, Campos AR, Whisenant TC, Donoghue DJ. Oncogenic mutations in IKKβ function through global changes induced by K63-linked ubiquitination and result in autocrine stimulation. Plos One. 13: e0206014. PMID 30335863 DOI: 10.1371/Journal.Pone.0206014 |
0.386 |
|
| 2016 |
Nelson KN, Peiris MN, Meyer AN, Siari A, Donoghue DJ. Receptor Tyrosine Kinases: Translocation Partners in Hematopoietic Disorders. Trends in Molecular Medicine. PMID 27988109 DOI: 10.1016/J.Molmed.2016.11.002 |
0.481 |
|
| 2016 |
Nelson KN, Meyer AN, Siari A, Campos AR, Motamedchaboki K, Donoghue DJ. Oncogenic Gene Fusion FGFR3-TACC3 is Regulated by Tyrosine Phosphorylation. Molecular Cancer Research : McR. PMID 26869289 DOI: 10.1158/1541-7786.Mcr-15-0497 |
0.419 |
|
| 2015 |
Gallo LH, Nelson KN, Meyer AN, Donoghue DJ. Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations. Cytokine & Growth Factor Reviews. PMID 26003532 DOI: 10.1016/J.Cytogfr.2015.03.003 |
0.491 |
|
| 2014 |
Gallo LH, Meyer AN, Motamedchaboki K, Nelson KN, Haas M, Donoghue DJ. Novel Lys63-linked ubiquitination of IKKβ induces STAT3 signaling. Cell Cycle (Georgetown, Tex.). 13: 3964-76. PMID 25486864 DOI: 10.4161/15384101.2014.988026 |
0.342 |
|
| 2014 |
Salazar L, Kashiwada T, Krejci P, Meyer AN, Casale M, Hallowell M, Wilcox WR, Donoghue DJ, Thompson LM. Fibroblast growth factor receptor 3 interacts with and activates TGFβ-activated kinase 1 tyrosine phosphorylation and NFκB signaling in multiple myeloma and bladder cancer. Plos One. 9: e86470. PMID 24466111 DOI: 10.1371/Journal.Pone.0086470 |
0.305 |
|
| 2014 |
Manickam K, Donoghue DJ, Meyer AN, Snyder PJ, Prior TW. Suppression of severe achondroplasia with developmental delay and acanthosis nigricans by the p.Thr651Pro mutation. American Journal of Medical Genetics. Part A. 164: 243-50. PMID 24352917 DOI: 10.1002/Ajmg.A.36236 |
0.458 |
|
| 2013 |
Meyer AN, Drafahl KA, McAndrew CW, Gilda JE, Gallo LH, Haas M, Brill LM, Donoghue DJ. Tyrosine phosphorylation allows integration of multiple signaling inputs by IKKβ. Plos One. 8: e84497. PMID 24386391 DOI: 10.1371/Journal.Pone.0084497 |
0.368 |
|
| 2013 |
Locascio LE, Donoghue DJ. KIDs rule: regulatory phosphorylation of RTKs. Trends in Biochemical Sciences. 38: 75-84. PMID 23312584 DOI: 10.1016/J.Tibs.2012.12.001 |
0.417 |
|
| 2009 |
Ahier A, Rondard P, Gouignard N, Khayath N, Huang S, Trolet J, Donoghue DJ, Gauthier M, Pin JP, Dissous C. A new family of receptor tyrosine kinases with a venus flytrap binding domain in insects and other invertebrates activated by aminoacids. Plos One. 4: e5651. PMID 19461966 DOI: 10.1371/Journal.Pone.0005651 |
0.389 |
|
| 2008 |
Meyer AN, McAndrew CW, Donoghue DJ. Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells. Cancer Research. 68: 7362-70. PMID 18794123 DOI: 10.1158/0008-5472.Can-08-0575 |
0.497 |
|
| 2005 |
Chen J, Williams IR, Lee BH, Duclos N, Huntly BJ, Donoghue DJ, Gilliland DG. Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation. Blood. 106: 328-37. PMID 15784730 DOI: 10.1182/Blood-2004-09-3686 |
0.401 |
|
| 2005 |
Barnes EA, Heidtman KJ, Donoghue DJ. Constitutive activation of the shh-ptc1 pathway by a patched1 mutation identified in BCC. Oncogene. 24: 902-15. PMID 15592520 DOI: 10.1038/Sj.Onc.1208240 |
0.436 |
|
| 2004 |
Meyer AN, Gastwirt RF, Schlaepfer DD, Donoghue DJ. The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation. The Journal of Biological Chemistry. 279: 28450-7. PMID 15105428 DOI: 10.1074/Jbc.M403335200 |
0.563 |
|
| 2002 |
Kong M, Wang CS, Donoghue DJ. Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation. The Journal of Biological Chemistry. 277: 15962-70. PMID 11827956 DOI: 10.1074/Jbc.M102777200 |
0.393 |
|
| 2001 |
Hart KC, Robertson SC, Donoghue DJ. Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Molecular Biology of the Cell. 12: 931-42. PMID 11294897 DOI: 10.1091/Mbc.12.4.931 |
0.712 |
|
| 2000 |
Bellus GA, Spector EB, Speiser PW, Weaver CA, Garber AT, Bryke CR, Israel J, Rosengren SS, Webster MK, Donoghue DJ, Francomano CA. Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype. American Journal of Human Genetics. 67: 1411-21. PMID 11055896 DOI: 10.1086/316892 |
0.546 |
|
| 2000 |
Bell CA, Tynan JA, Hart KC, Meyer AN, Robertson SC, Donoghue DJ. Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase. Molecular Biology of the Cell. 11: 3589-99. PMID 11029057 DOI: 10.1091/Mbc.11.10.3589 |
0.647 |
|
| 2000 |
Hart KC, Robertson SC, Kanemitsu MY, Meyer AN, Tynan JA, Donoghue DJ. Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene. 19: 3309-20. PMID 10918587 DOI: 10.1038/Sj.Onc.1203650 |
0.703 |
|
| 2000 |
Hart KC, Robertson SC, Donoghue DJ. Activation of H-ras61L-specific signaling pathways does not require posttranslational processing of H-ras. Experimental Cell Research. 257: 89-100. PMID 10854057 DOI: 10.1006/Excr.2000.4874 |
0.557 |
|
| 2000 |
Robertson SC, Tynan JA, Donoghue DJ. RTK mutations and human syndromeswhen good receptors turn bad. Trends in Genetics : Tig. 16: 265-71. PMID 10827454 DOI: 10.1016/S0168-9525(00)02021-7 |
0.643 |
|
| 1999 |
Tavormina PL, Bellus GA, Webster MK, Bamshad MJ, Fraley AE, McIntosh I, Szabo J, Jiang W, Jabs EW, Wilcox WR, Wasmuth JJ, Donoghue DJ, Thompson LM, Francomano CA. A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene. American Journal of Human Genetics. 64: 722-31. PMID 10053006 DOI: 10.1086/302275 |
0.501 |
|
| 1998 |
Robertson SC, Meyer AN, Hart KC, Galvin BD, Webster MK, Donoghue DJ. Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain. Proceedings of the National Academy of Sciences of the United States of America. 95: 4567-72. PMID 9539778 DOI: 10.1073/Pnas.95.8.4567 |
0.69 |
|
| 1998 |
d'Avis PY, Robertson SC, Meyer AN, Bardwell WM, Webster MK, Donoghue DJ. Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 9: 71-8. PMID 9438390 |
0.697 |
|
| 1997 |
Webster MK, Donoghue DJ. Enhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domain. Molecular and Cellular Biology. 17: 5739-47. PMID 9315632 DOI: 10.1128/Mcb.17.10.5739 |
0.504 |
|
| 1997 |
Webster MK, Donoghue DJ. FGFR activation in skeletal disorders: too much of a good thing. Trends in Genetics : Tig. 13: 178-82. PMID 9154000 DOI: 10.1016/S0168-9525(97)01131-1 |
0.475 |
|
| 1997 |
Chen LI, Webster MK, Meyer AN, Donoghue DJ. Transmembrane domain sequence requirements for activation of the p185c-neu receptor tyrosine kinase. The Journal of Cell Biology. 137: 619-31. PMID 9151669 DOI: 10.1083/Jcb.137.3.619 |
0.504 |
|
| 1997 |
Li J, Meyer AN, Donoghue DJ. Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 94: 502-7. PMID 9012813 DOI: 10.1073/Pnas.94.2.502 |
0.42 |
|
| 1997 |
Robertson S, Meyer A, Hart K, Webster M, Donoghue D. Cysteine independent activation of fgfr2 by crouzon syndrome mutants Faseb Journal. 11. |
0.535 |
|
| 1996 |
Galvin BD, Hart KC, Meyer AN, Webster MK, Donoghue DJ. Constitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimeras. Proceedings of the National Academy of Sciences of the United States of America. 93: 7894-9. PMID 8755573 DOI: 10.1073/Pnas.93.15.7894 |
0.55 |
|
| 1996 |
Webster MK, D'Avis PY, Robertson SC, Donoghue DJ. Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II. Molecular and Cellular Biology. 16: 4081-7. PMID 8754806 DOI: 10.1128/Mcb.16.8.4081 |
0.713 |
|
| 1996 |
Robertson SC, Donoghue DJ. Identification of an autoinhibitory region in the activation loop of the Mos protein kinase. Molecular and Cellular Biology. 16: 3472-9. PMID 8668163 DOI: 10.1128/Mcb.16.7.3472 |
0.635 |
|
| 1996 |
Webster MK, Donoghue DJ. Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia. The Embo Journal. 15: 520-7. PMID 8599935 DOI: 10.1002/J.1460-2075.1996.Tb00384.X |
0.58 |
|
| 1995 |
Li J, Meyer AN, Donoghue DJ. Requirement for phosphorylation of cyclin B1 for Xenopus oocyte maturation. Molecular Biology of the Cell. 6: 1111-24. PMID 8534910 DOI: 10.1091/Mbc.6.9.1111 |
0.32 |
|
| 1994 |
Meyer AN, Xu YF, Webster MK, Smith AE, Donoghue DJ. Cellular transformation by a transmembrane peptide: structural requirements for the bovine papillomavirus E5 oncoprotein. Proceedings of the National Academy of Sciences of the United States of America. 91: 4634-8. PMID 8197111 DOI: 10.1073/Pnas.91.11.4634 |
0.42 |
|
| 1994 |
Pickham KM, Donoghue DJ. Mutants at Ser277 of Xenopus cdc2 protein kinase induce oocyte maturation in the absence of the positive regulatory phosphorylation site Thr161. Molecular Biology of the Cell. 5: 587-96. PMID 7919539 DOI: 10.1091/Mbc.5.5.587 |
0.49 |
|
| 1993 |
Maher DW, Strawn LM, Donoghue DJ. Alanine mutagenesis of conserved residues in the platelet-derived growth factor family: identification of residues necessary for dimerization and transformation. Oncogene. 8: 533-41. PMID 8437840 |
0.319 |
|
| 1992 |
Freeman RS, Meyer AN, Li J, Donoghue DJ. Phosphorylation of conserved serine residues does not regulate the ability of mosxe protein kinase to induce oocyte maturation or function as cytostatic factor. The Journal of Cell Biology. 116: 725-35. PMID 1530949 DOI: 10.1083/Jcb.116.3.725 |
0.373 |
|
| 1992 |
Pickham KM, Meyer AN, Li J, Donoghue DJ. Requirement of mosXe protein kinase for meiotic maturation of Xenopus oocytes induced by a cdc2 mutant lacking regulatory phosphorylation sites. Molecular and Cellular Biology. 12: 3192-203. PMID 1377775 DOI: 10.1128/Mcb.12.7.3192 |
0.373 |
|
| 1992 |
Lee MS, Ogg S, Xu M, Parker LL, Donoghue DJ, Maller JL, Piwnica-Worms H. cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2. Molecular Biology of the Cell. 3: 73-84. PMID 1312880 DOI: 10.1091/Mbc.3.1.73 |
0.316 |
|
| 1989 |
Freeman RS, Donoghue DJ. Transforming mutant v-mos protein kinases that are deficient in in vitro autophosphorylation. Molecular and Cellular Biology. 9: 4087-90. PMID 2528689 DOI: 10.1128/Mcb.9.9.4087 |
0.345 |
|
| 1989 |
Freeman RS, Pickham KM, Kanki JP, Lee BA, Pena SV, Donoghue DJ. Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 86: 5805-9. PMID 2527365 DOI: 10.1073/Pnas.86.15.5805 |
0.323 |
|
| 1988 |
Singh B, Wittenberg C, Hannink M, Reed SI, Donoghue DJ, Arlinghaus RB. The histidine-221 to tyrosine substitution in v-mos abolishes its biological function and its protein kinase activity. Virology. 164: 114-20. PMID 2966489 DOI: 10.1016/0042-6822(88)90626-5 |
0.446 |
|
| 1986 |
Singh B, Hannink M, Donoghue DJ, Arlinghaus RB. p37mos-associated serine/threonine protein kinase activity correlates with the cellular transformation function of v-mos. Journal of Virology. 60: 1148-1152. DOI: 10.1128/jvi.60.3.1148-1152.1986 |
0.312 |
|
| 1985 |
Hannink M, Donoghue DJ. Lysine residue 121 in the proposed ATP-binding site of the v-mos protein is required for transformation Proceedings of the National Academy of Sciences of the United States of America. 82: 7894-7898. PMID 2999782 DOI: 10.1073/Pnas.82.23.7894 |
0.369 |
|
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