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Eugene Khandros, Ph.D. - Publications

Affiliations: 
2012 Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
Cell Biology, Molecular Biology, Biochemistry
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27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Huang P, Peslak SA, Ren R, Khandros E, Qin K, Keller CA, Giardine B, Bell HW, Lan X, Sharma M, Horton JR, Abdulmalik O, Chou ST, Shi J, Crossley M, et al. HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription. Nature Genetics. PMID 35941187 DOI: 10.1038/s41588-022-01152-6  0.319
2022 Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, et al. Publisher Correction: Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells. Nature Genetics. PMID 35650318 DOI: 10.1038/s41588-022-01112-0  0.426
2022 Wakabayashi A, Kihiu M, Sharma M, Thrasher AJ, Saari MS, Quesnel-Vallieres M, Abdulmalik O, Peslak SA, Khandros E, Keller CA, Giardine BM, Barash Y, Hardison RC, Shi J, Blobel GA. Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression. Blood Advances. PMID 35622975 DOI: 10.1182/bloodadvances.2022007904  0.343
2022 Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, et al. Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells. Nature Genetics. PMID 35618846 DOI: 10.1038/s41588-022-01076-1  0.513
2020 Peslak SA, Khandros E, Huang P, Lan X, Geronimo CL, Grevet JD, Abdulmalik O, Zhang Z, Giardine BM, Keller CA, Shi J, Hardison RC, Blobel GA. HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation. Blood Advances. 4: 4560-4572. PMID 32956454 DOI: 10.1182/Bloodadvances.2020002475  0.389
2020 Huang P, Peslak SA, Lan X, Khandros E, Yano JA, Sharma M, Keller CA, Giardine BM, Qin K, Abdulmalik O, Hardison R, Shi J, Blobel GA. HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression. Blood. PMID 32299090 DOI: 10.1182/Blood.2020005301  0.44
2020 Khandros E, Huang P, Peslak SA, Sharma M, Abdulmalik O, Giardine BM, Zhang Z, Keller CA, Hardison R, Blobel GA. Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of F- and A-erythroblasts. Blood. PMID 32268371 DOI: 10.1182/Blood.2020005058  0.376
2019 Lechauve C, Keith J, Khandros E, Fowler S, Mayberry K, Freiwan A, Thom CS, Delbini P, Romero EB, Zhang J, Motta I, Tillman H, Cappellini MD, Kundu M, Weiss MJ. The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia. Science Translational Medicine. 11. PMID 31434755 DOI: 10.1126/Scitranslmed.Aav4881  0.517
2019 Chonat S, Risinger M, Sakthivel H, Niss O, Rothman JA, Hsieh L, Chou ST, Kwiatkowski JL, Khandros E, Gorman MF, Wells DT, Maghathe T, Dagaonkar N, Seu KG, Zhang K, et al. The Spectrum of -Associated Hereditary Spherocytosis. Frontiers in Physiology. 10: 815. PMID 31333484 DOI: 10.3389/Fphys.2019.00815  0.393
2019 Lan X, Khandros E, Huang P, Peslak SA, Bhardwaj SK, Grevet JD, Abdulmalik O, Wang H, Keller CA, Giardine B, Baeza J, Duffner ER, El Demerdash O, Wu XS, Vakoc CR, et al. The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells. Blood Advances. 3: 1586-1597. PMID 31126914 DOI: 10.1182/Bloodadvances.2019032318  0.463
2019 Peslak SA, Lan X, Khandros E, Huang P, Yano JA, Grevet JD, Abdulmalik O, Keller CA, Hardison RC, Shi J, Blobel GA. Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation Blood. 134: 3557-3557. DOI: 10.1182/Blood-2019-125664  0.394
2019 Khandros E, Huang P, Peslak SA, Giardine B, Zhang Z, Keller CA, Hardison RC, Blobel GA. Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of Stage-Matched F- and a-Cells Blood. 134: 981-981. DOI: 10.1182/Blood-2019-124099  0.396
2019 Huang P, Peslak SA, Lan X, Khandros E, Sharma M, Qin K, Keller CA, Giardine B, Shi J, Hardison RC, Blobel GA. Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing Blood. 134: 814-814. DOI: 10.1182/Blood-2019-123837  0.469
2018 Lan X, Khandros E, Grevet JD, Peslak SA, Bhardwaj S, Keller CA, Giardine B, Garcia BA, Hardison RC, Shi J, Blobel GA. Domain-Focused CRISPR-Cas9 Screen Identifies the E3 Ubiquitin Ligase Substrate Adaptor Protein SPOP as a Novel Repressor of Fetal Hemoglobin Blood. 132: 414-414. DOI: 10.1182/Blood-2018-99-119518  0.437
2018 Lechauve C, Keith J, Khandros E, Fowler S, Mayberry K, Freiwan A, Thom C, Zhang J, Tillman H, Kundu M, Motta I, Cappellini MD, Weiss MJ. Activation of ULK1 Kinase Mediates Clearance of Free Alpha-Globin in Human Beta-Thalassemic Erythroblasts Blood. 132: 411-411. DOI: 10.1182/Blood-2018-99-113901  0.537
2014 Thom CS, Traxler EA, Khandros E, Nickas JM, Zhou OY, Lazarus JE, Silva AP, Prabhu D, Yao Y, Aribeana C, Fuchs SY, Mackay JP, Holzbaur EL, Weiss MJ. Trim58 degrades Dynein and regulates terminal erythropoiesis. Developmental Cell. 30: 688-700. PMID 25241935 DOI: 10.1016/J.Devcel.2014.07.021  0.525
2013 Dickson CF, Rich AM, D'Avigdor WM, Collins DA, Lowry JA, Mollan TL, Khandros E, Olson JS, Weiss MJ, Mackay JP, Lay PA, Gell DA. α-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-α-hemoglobin and weakens the iron-oxygen bond. The Journal of Biological Chemistry. 288: 19986-20001. PMID 23696640 DOI: 10.1074/Jbc.M112.437509  0.486
2013 Zou Z, Enis DR, Bui H, Khandros E, Kumar V, Jakus Z, Thom C, Yang Y, Dhillon V, Chen M, Lu M, Weiss MJ, Kahn ML. The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood. 121: 3228-36. PMID 23426945 DOI: 10.1182/Blood-2012-10-462689  0.513
2012 Khandros E, Thom CS, D'Souza J, Weiss MJ. Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia. Blood. 119: 5265-75. PMID 22427201 DOI: 10.1182/Blood-2011-12-397729  0.576
2012 Mollan TL, Khandros E, Weiss MJ, Olson JS. Kinetics of α-globin binding to α-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate. The Journal of Biological Chemistry. 287: 11338-50. PMID 22298770 DOI: 10.1074/Jbc.M111.313247  0.507
2012 Khandros E, Mollan TL, Yu X, Wang X, Yao Y, D'Souza J, Gell DA, Olson JS, Weiss MJ. Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein. The Journal of Biological Chemistry. 287: 11325-37. PMID 22287545 DOI: 10.1074/Jbc.M111.313205  0.597
2012 Thom CS, Khandros E, Yao Y, Nickas JM, Lazarus JE, Prabhu D, Zhou OY, Holzbaur EL, Weiss MJ. Trim58 Is a Putative E3 Ubiquitin Ligase That Functions in Late Stage Erythropoiesis Blood. 120: 83-83. DOI: 10.1182/Blood.V120.21.83.83  0.561
2010 Khandros E, Weiss MJ. Protein quality control during erythropoiesis and hemoglobin synthesis. Hematology/Oncology Clinics of North America. 24: 1071-88. PMID 21075281 DOI: 10.1016/J.Hoc.2010.08.013  0.539
2010 Nasimuzzaman M, Khandros E, Wang X, Kong Y, Zhao H, Weiss D, Rivella S, Weiss MJ, Persons DA. Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia. American Journal of Hematology. 85: 820-2. PMID 20815047 DOI: 10.1002/Ajh.21829  0.577
2010 Yu D, dos Santos CO, Zhao G, Jiang J, Amigo JD, Khandros E, Dore LC, Yao Y, D'Souza J, Zhang Z, Ghaffari S, Choi J, Friend S, Tong W, Orange JS, et al. miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes & Development. 24: 1620-33. PMID 20679398 DOI: 10.1101/Gad.1942110  0.466
2009 Chou ST, Khandros E, Bailey LC, Nichols KE, Vakoc CR, Yao Y, Huang Z, Crispino JD, Hardison RC, Blobel GA, Weiss MJ. Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate. Blood. 114: 983-94. PMID 19491391 DOI: 10.1182/Blood-2009-03-207944  0.548
2009 Kirino Y, Kim N, de Planell-Saguer M, Khandros E, Chiorean S, Klein PS, Rigoutsos I, Jongens TA, Mourelatos Z. Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability. Nature Cell Biology. 11: 652-8. PMID 19377467 DOI: 10.1038/Ncb1872  0.404
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