| Year |
Citation |
Score |
| 2023 |
Zhang L, Martin G, Mohankumar K, Wright GA, Mariyam F, Safe S. Piperlongumine is a ligand for the orphan nuclear receptor 4A1 (NR4A1). Frontiers in Pharmacology. 14: 1223153. PMID 37808182 DOI: 10.3389/fphar.2023.1223153 |
0.384 |
|
| 2023 |
Zhang L, Mohankumar K, Martin G, Mariyam F, Park Y, Han SJ, Safe S. Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice. Endocrinology. PMID 37652054 DOI: 10.1210/endocr/bqad133 |
0.312 |
|
| 2022 |
Safe S, Zhang L. The Role of the Aryl Hydrocarbon Receptor (AhR) and Its Ligands in Breast Cancer. Cancers. 14. PMID 36428667 DOI: 10.3390/cancers14225574 |
0.352 |
|
| 2022 |
Schoeller A, Karki K, Jayaraman A, Chapkin RS, Safe S. Short chain fatty acids exhibit selective estrogen receptor downregulator (SERD) activity in breast cancer. American Journal of Cancer Research. 12: 3422-3436. PMID 35968335 |
0.328 |
|
| 2022 |
Park H, Jin UH, Martin G, Chapkin RS, Davidson LA, Lee K, Jayaraman A, Safe S. Structure-activity relationships among mono- and dihydroxy flavones as aryl hydrocarbon receptor (AhR) agonists or antagonists in CACO2 cells. Chemico-Biological Interactions. 365: 110067. PMID 35917944 DOI: 10.1016/j.cbi.2022.110067 |
0.328 |
|
| 2022 |
Zhang L, Martin G, Mohankumar K, Hampton JT, Liu WR, Safe S. . Molecular Pharmacology. PMID 35680166 DOI: 10.1124/molpharm.121.000481 |
0.333 |
|
| 2022 |
Zarei M, Shrestha R, Johnson S, Yu Z, Karki K, Vaziri-Gohar A, Epps J, Du H, Suva L, Zarei M, Safe S. Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma. Cancer Research Communications. 1: 65-78. PMID 35582016 DOI: 10.1158/2767-9764.crc-21-0073 |
0.341 |
|
| 2022 |
Lee HS, Kim DH, Lee IS, Park JH, Martin G, Safe S, Kim KJ, Kim JH, Jang BI, Lee SO. Plant Alkaloid Tetrandrine Is a Nuclear Receptor 4A1 Antagonist and Inhibits Panc-1 Cell Growth In Vitro and In Vivo. International Journal of Molecular Sciences. 23. PMID 35563670 DOI: 10.3390/ijms23095280 |
0.405 |
|
| 2021 |
Safe S, Shrestha R, Mohankumar K, Howard M, Hedrick E, Abdelrahim M. Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer. World Journal of Gastroenterology. 27: 6387-6398. PMID 34720529 DOI: 10.3748/wjg.v27.i38.6387 |
0.341 |
|
| 2021 |
Mohankumar K, Shrestha R, Safe S. Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells. Molecular Carcinogenesis. PMID 34699643 DOI: 10.1002/mc.23362 |
0.405 |
|
| 2021 |
Karki K, Mohankumar K, Schoeller A, Martin G, Shrestha R, Safe S. NR4A1 Ligands as Potent Inhibitors of Breast Cancer Cell and Tumor Growth. Cancers. 13. PMID 34072371 DOI: 10.3390/cancers13112682 |
0.364 |
|
| 2021 |
Lee HS, Kim SH, Kim BM, Safe S, Lee SO. Broussochalcone A Is a Novel Inhibitor of the Orphan Nuclear Receptor NR4A1 and Induces Apoptosis in Pancreatic Cancer Cells. Molecules (Basel, Switzerland). 26. PMID 33923503 DOI: 10.3390/molecules26082316 |
0.405 |
|
| 2021 |
Chidambara Murthy KN, Jayaprakasha GK, Safe S, Patil BS. Citrus limonoids induce apoptosis and inhibit the proliferation of pancreatic cancer cells. Food & Function. PMID 33427831 DOI: 10.1039/d0fo02740e |
0.34 |
|
| 2020 |
Park H, Jin UH, Karki K, Allred C, Davidson LA, Chapkin RS, Orr AA, Nowshad F, Jayaraman A, Tamamis P, Safe S. Hydroxylated Chalcones as Aryl Hydrocarbon Receptor Agonists: Structure-Activity Effects. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 33263770 DOI: 10.1093/toxsci/kfaa179 |
0.358 |
|
| 2020 |
Safe S, Karki K. The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer. Molecular Cancer Research : McR. PMID 33106376 DOI: 10.1158/1541-7786.MCR-20-0707 |
0.346 |
|
| 2020 |
Safe S, Jin UH, Park H, Chapkin RS, Jayaraman A. Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs). International Journal of Molecular Sciences. 21. PMID 32932962 DOI: 10.3390/Ijms21186654 |
0.37 |
|
| 2020 |
Shrestha R, Mohankumar K, Safe S. Bis-indole derived nuclear receptor 4A1 (NR4A1) antagonists inhibit TGFβ-induced invasion of embryonal rhabdomyosarcoma cells. American Journal of Cancer Research. 10: 2495-2509. PMID 32905449 |
0.349 |
|
| 2020 |
Jin UH, Michelhaugh SK, Polin LA, Shrestha R, Mittal S, Safe S. Omeprazole Inhibits Glioblastoma Cell Invasion and Tumor Growth. Cancers. 12. PMID 32731514 DOI: 10.3390/Cancers12082097 |
0.415 |
|
| 2020 |
Safe S, Jayaraman A, Chapkin RS. Ah receptor ligands and their impacts on gut resilience: structure-activity effects. Critical Reviews in Toxicology. 1-11. PMID 32597352 DOI: 10.1080/10408444.2020.1773759 |
0.361 |
|
| 2020 |
Mohankumar K, Li X, Sung N, Cho YJ, Han SJ, Safe S. BIS-INDOLE DERIVED NUCLEAR RECEPTOR 4A1 (NR4A1, Nur77) LIGANDS AS INHIBITORS OF ENDOMETRIOSIS. Endocrinology. PMID 32099996 DOI: 10.1210/Endocr/Bqaa027 |
0.431 |
|
| 2020 |
Nottingham E, Sekar V, Mondal A, Safe S, Rishi A, Singh M. The role of Self Nano Emulsifying drug delivery systems of CDODA-Me in sensitizing Erlotinib resistant Nonsmall cell lung cancer. Journal of Pharmaceutical Sciences. PMID 31954111 DOI: 10.1016/J.Xphs.2020.01.010 |
0.351 |
|
| 2020 |
Karki K, Wright GA, Mohankumar K, Jin UH, Zhang XH, Safe S. A Bis-Indole-Derived NR4A1 Antagonist Induces PD-L1 Degradation and Enhances Anti-Tumor Immunity. Cancer Research. PMID 31911554 DOI: 10.1158/0008-5472.Can-19-2314 |
0.342 |
|
| 2020 |
Garcia-Villatoro EL, DeLuca JA, Callaway ES, Allred KF, Davidson LA, Hensel ME, Menon R, Ivanov I, Safe S, Jayaraman A, Chapkin RS, Allred CD. Effects Of High Fat Diet And Intestinal Aryl Hydrocarbon Receptor Deletion On Colon Carcinogenesis. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 31905023 DOI: 10.1152/Ajpgi.00268.2019 |
0.321 |
|
| 2019 |
Karki K, Li X, Jin UH, Mohankumar K, Zarei M, Michelhaugh SK, Mittal S, Tjalkens R, Safe S. Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas. Journal of Neuro-Oncology. PMID 31754919 DOI: 10.1007/S11060-019-03349-Y |
0.325 |
|
| 2019 |
Park H, Jin UH, Orr AA, Echegaray SP, Davidson LA, Allred CD, Chapkin R, Jayaraman A, Lee K, Tamamis P, Safe SH. Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure-Activity Relationships. Chemical Research in Toxicology. PMID 31621310 DOI: 10.1021/Acs.Chemrestox.9B00352 |
0.451 |
|
| 2019 |
Safe S, Hedrick E, Mohankumar K, Lacey A. INHIBITION OF NR4A1 PROMOTES ROS ACCUMULATION AND IL-24 - DEPENDENT GROWTH ARREST IN RHABDOMYOSARCOMA. Molecular Cancer Research : McR. PMID 31462501 DOI: 10.1158/1541-7786.Mcr-19-0408 |
0.387 |
|
| 2019 |
Jin UH, Karki K, Cheng Y, Michelhaugh SK, Mittal S, Safe S. The aryl hydrocarbon receptor is a tumor suppressor-like gene in glioblastoma. The Journal of Biological Chemistry. PMID 31171720 DOI: 10.1074/Jbc.Ra119.008882 |
0.412 |
|
| 2019 |
Hedrick E, Li X, Cheng Y, Lacey A, Mohankumar K, Zarei M, Safe S. Potent inhibition of breast cancer by bis-indole-derived nuclear receptor 4A1 (NR4A1) antagonists. Breast Cancer Research and Treatment. PMID 31119568 DOI: 10.1007/S10549-019-05279-9 |
0.458 |
|
| 2019 |
Li X, Tjalkens RB, Shrestha R, Safe S. Structure-dependent Activation of Gene Expression by Bis-indole and Quinoline-derived Activators of Nuclear Receptor 4A2. Chemical Biology & Drug Design. PMID 31102570 DOI: 10.1111/Cbdd.13564 |
0.436 |
|
| 2019 |
Mohankumar K, Li X, Sridharan S, Karki K, Safe S. Nuclear receptor 4A1 (NR4A1) antagonists induce ROS-dependent inhibition of mTOR signaling in endometrial cancer. Gynecologic Oncology. PMID 31053403 DOI: 10.1016/J.Ygyno.2019.04.678 |
0.438 |
|
| 2019 |
Yoon K, Chen CC, Orr AA, Barreto PN, Tamamis P, Safe S. Activation of COUP-TFI by a Novel Diindolylmethane Derivative. Cells. 8. PMID 30866413 DOI: 10.3390/Cells8030220 |
0.676 |
|
| 2019 |
Kasiappan R, Jutooru I, Mohankumar K, Karki K, Lacey A, Safe S. Reactive Oxygen Species (ROS)-inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors. Molecular Cancer Research : McR. PMID 30610105 DOI: 10.1158/1541-7786.Mcr-18-1071 |
0.774 |
|
| 2019 |
Jin U, Karki K, Safe S. Abstract 154: Inhibition of pancreatic cancer Panc-1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-154 |
0.462 |
|
| 2019 |
Harishchandra S, Li X, Safe S, Zarei M. Abstract 1714: Nuclear receptor Nurr1 facilitates pancreatic ductal adenocarcinoma cell survival under metabolic stress Cancer Research. 79: 1714-1714. DOI: 10.1158/1538-7445.Am2019-1714 |
0.42 |
|
| 2018 |
Safe S, Han H, Goldsby J, Mohankumar K, Chapkin RS. Aryl Hydrocarbon Receptor (AhR) Ligands as Selective AhR Modulators: Genomic Studies. Current Opinion in Toxicology. 11: 10-20. PMID 31453421 DOI: 10.1016/J.Cotox.2018.11.005 |
0.323 |
|
| 2018 |
Karki K, Harishchandra S, Safe SH. Bortezomib Targets Sp Transcription Factors in Cancer Cells. Molecular Pharmacology. PMID 30115673 DOI: 10.1124/mol.118.112797 |
0.361 |
|
| 2018 |
Hedrick E, Mohankumar K, Safe S. TGFbeta-induced Lung Cancer Cell Migration is NR4A1-dependent. Molecular Cancer Research : McR. PMID 30072581 DOI: 10.1158/1541-7786.Mcr-18-0366 |
0.381 |
|
| 2018 |
Afzali MF, Popichak KA, Burton LH, Klochak AL, Wilson WJ, Safe S, Tjalkens RB, Legare ME. A novel diindolylmethane analog, 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) methane, inhibits the tumor necrosis factor-induced inflammatory response in primary murine synovial fibroblasts through a Nurr1-dependent mechanism. Molecular Immunology. 101: 46-54. PMID 29870816 DOI: 10.1016/J.Molimm.2018.05.024 |
0.364 |
|
| 2018 |
Jin UH, Karki K, Kim SB, Safe S. Inhibition of pancreatic cancer Panc1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK. Biochemical and Biophysical Research Communications. PMID 29758193 DOI: 10.1016/J.Bbrc.2018.05.061 |
0.453 |
|
| 2018 |
Mohankumar K, Lee J, Wu CS, Sun Y, Safe S. Bis-Indole-Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells. Endocrinology. 159: 1950-1963. PMID 29635345 DOI: 10.1210/En.2017-03049 |
0.368 |
|
| 2018 |
Hammond SL, Popichak KA, Li X, Hunt LG, Richman EH, Damale P, Chong E, Backos DS, Safe S, Tjalkens RB. The Nurr1 ligand,1,1-bis(3'-indolyl)-1-(p-chlorophenyl)methane, modulates glial reactivity and is neuroprotective in MPTP-induced parkinsonism. The Journal of Pharmacology and Experimental Therapeutics. PMID 29626009 DOI: 10.1124/Jpet.117.246389 |
0.353 |
|
| 2018 |
Draz H, Goldberg AA, Tomlinson Guns ES, Fazli L, Safe S, Sanderson JT. Autophagy inhibition improves the chemotherapeutic efficacy of cruciferous vegetable-derived diindolymethane in a murine prostate cancer xenograft model. Investigational New Drugs. PMID 29607466 DOI: 10.1007/S10637-018-0595-8 |
0.372 |
|
| 2018 |
Jin UH, Park H, Li X, Davidson LA, Allred C, Patil B, Jayaprakasha G, Orr AA, Mao L, Chapkin RS, Jayaraman A, Tamamis P, Safe S. Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavones. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29584932 DOI: 10.1093/Toxsci/Kfy075 |
0.413 |
|
| 2018 |
Safe S, Abbruzzese JL, Abdelrahim M, Hedrick E. Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development. Cancer Prevention Research (Philadelphia, Pa.). PMID 29545399 DOI: 10.1158/1940-6207.Capr-17-0407 |
0.482 |
|
| 2018 |
Choudhary M, Safe S, Malek G. Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor. Biochimica Et Biophysica Acta. PMID 29481912 DOI: 10.1016/J.Bbadis.2018.02.015 |
0.364 |
|
| 2018 |
Cheng Y, Imanirad P, Jutooru I, Hedrick E, Jin UH, Rodrigues Hoffman A, Leal de Araujo J, Morpurgo B, Golovko A, Safe S. Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer. Plos One. 13: e0192264. PMID 29389953 DOI: 10.1371/Journal.Pone.0192264 |
0.765 |
|
| 2017 |
Safe S, Naira V, Karki K. Metformin-induced anticancer activities: recent insights. Biological Chemistry. PMID 29272251 DOI: 10.1515/Hsz-2017-0271 |
0.465 |
|
| 2017 |
Li Y, Wang F, Lu L, Zhu F, Huang S, Nomie K, Zhang L, Yang DT, Huang W, Kahl BS, Safe S, Wang M, Rui L. NR4A1 inhibition synergizes with ibrutinib in killing mantle cell lymphoma cells. Blood Cancer Journal. 7: 632. PMID 29167454 DOI: 10.1038/S41408-017-0005-Z |
0.347 |
|
| 2017 |
Safe S. Carbidopa: a selective Ah receptor modulator (SAhRM). The Biochemical Journal. 474: 3763-3765. PMID 29109131 DOI: 10.1042/Bcj20170728 |
0.434 |
|
| 2017 |
Jin UH, Cheng Y, Park H, Davidson LA, Callaway ES, Chapkin RS, Jayaraman A, Asante A, Allred C, Weaver EA, Safe S. Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells. Scientific Reports. 7: 10163. PMID 28860561 DOI: 10.1038/S41598-017-10824-X |
0.414 |
|
| 2017 |
Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S. Correction for Hedrick et al., "NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration". Molecular and Cellular Biology. 37. PMID 28847971 DOI: 10.1128/Mcb.00197-17 |
0.349 |
|
| 2017 |
Lee HS, Safe S, Lee SO. Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells. Toxicology and Applied Pharmacology. PMID 28754437 DOI: 10.1016/J.Taap.2017.07.017 |
0.501 |
|
| 2017 |
Kolluri SK, Jin UH, Safe S. Erratum to: Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target. Archives of Toxicology. PMID 28695231 DOI: 10.1007/S00204-017-2026-6 |
0.34 |
|
| 2017 |
Hedrick E, Safe S. TGFβ/NR4A1 Inducible Breast Cancer Cell Migration and Epithelial to Mesenchymal Transition is p38α (MAPK14) Dependent. Molecular and Cellular Biology. PMID 28674186 DOI: 10.1128/Mcb.00306-17 |
0.414 |
|
| 2017 |
Karki K, Hedrick E, Kasiappan R, Jin UH, Safe S. Piperlongumine Induces Reactive Oxygen Species (ROS)-dependent Downregulation of Specificity Protein Transcription Factors. Cancer Prevention Research (Philadelphia, Pa.). PMID 28673967 DOI: 10.1158/1940-6207.Capr-17-0053 |
0.472 |
|
| 2017 |
Kolluri SK, Jin UH, Safe S. Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target. Archives of Toxicology. PMID 28508231 DOI: 10.1007/S00204-017-1981-2 |
0.428 |
|
| 2017 |
Safe S, Cheng Y, Jin UH. The Aryl Hydrocarbon Receptor (AhR) as a Drug Target for Cancer Chemotherapy. Current Opinion in Toxicology. 2: 24-29. PMID 28459113 DOI: 10.1016/J.Cotox.2017.01.012 |
0.435 |
|
| 2017 |
Hedrick E, Lee SO, Safe S. The Nuclear Orphan Receptor NR4A1 Regulates β1-Integrin Expression in Pancreatic and Colon Cancer Cells and Can Be Targeted by NR4A1 Antagonists. Molecular Carcinogenesis. PMID 28418095 DOI: 10.1002/Mc.22662 |
0.422 |
|
| 2017 |
Taoka R, Jinesh GG, Xue W, Safe S, Kamat AM. CF3DODA-Me induces apoptosis, degrades Sp1, and blocks the transformation phase of the blebbishield emergency program. Apoptosis : An International Journal On Programmed Cell Death. PMID 28283889 DOI: 10.1007/S10495-017-1359-1 |
0.388 |
|
| 2017 |
Jin U, Cheng Y, Zhou B, Safe S. The Antineoplastic Activity of Bardoxolone Methyl and a Related Triterpenoid in Leukemia Cells Is Due to Reactive Oxygen Species-Dependent Suppression of cMyc. Molecular Pharmacology. PMID 28275049 DOI: 10.1124/Mol.116.106245 |
0.437 |
|
| 2017 |
Draz H, Goldberg A, Sanderson T, Safe S. Abstract 3298: Diindolylmethane and its halogenated analogues induce autophagy in human prostate cancer cells via induction of the astrocyte-elevated gene-1 (AEG-1) Cancer Research. 77: 3298-3298. DOI: 10.1158/1538-7445.Am2017-3298 |
0.409 |
|
| 2016 |
Kasiappan R, Jutooru I, Karki K, Hedrick E, Safe SH. Benzylisothiocyanate (BITC) Induces ROS-dependent Repression of STAT3 by Downregulation of Specificity Proteins in Pancreatic Cancer. The Journal of Biological Chemistry. PMID 27875298 DOI: 10.1074/Jbc.M116.746339 |
0.773 |
|
| 2016 |
Lacey A, Rodrigues Hoffman A, Safe S. PAX3-FOXO1A expression in rhabdomyosarcoma is driven by the targetable nuclear receptor NR4A1. Cancer Research. PMID 27864345 DOI: 10.1158/0008-5472.Can-16-1546 |
0.422 |
|
| 2016 |
Cheng Y, Jin UH, Davidson LA, Chapkin RS, Jayaraman A, Tamamis P, Orr A, Allred C, Denison MS, Soshilov A, Weaver E, Safe S. Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27837168 DOI: 10.1093/Toxsci/Kfw230 |
0.434 |
|
| 2016 |
Bridi MS, Hawk JD, Chatterjee S, Safe S, Abel T. Pharmacological Activators of the NR4A Nuclear Receptors Enhance LTP in a CREB/CBP-Dependent Fashion. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27834392 DOI: 10.1038/Npp.2016.253 |
0.31 |
|
| 2016 |
Hedrick E, Li X, Safe S. Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors. Molecular Cancer Therapeutics. PMID 27811009 DOI: 10.1158/1535-7163.Mct-16-0451 |
0.422 |
|
| 2016 |
Safe S, Kasiappan R. Natural Products as Mechanism-based Anticancer Agents: Sp Transcription Factors as Targets. Phytotherapy Research : Ptr. PMID 27384261 DOI: 10.1002/Ptr.5669 |
0.478 |
|
| 2016 |
Moore RW, Fritz WA, Schneider AJ, Lin TM, Branam AM, Safe S, Peterson RE. 2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice. Toxicology and Applied Pharmacology. PMID 27151233 DOI: 10.1016/J.Taap.2016.04.018 |
0.318 |
|
| 2016 |
Lacey A, Hedrick E, Li X, Patel K, Doddapaneni R, Singh M, Safe S. Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS). Oncotarget. PMID 27144436 DOI: 10.18632/Oncotarget.9112 |
0.485 |
|
| 2016 |
Takeuchi H, Taoka R, Mmeje CO, Jinesh GG, Safe S, Kamat AM. CDODA-Me decreases specificity protein transcription factors and induces apoptosis in bladder cancer cells through induction of reactive oxygen species. Urologic Oncology. PMID 27038699 DOI: 10.1016/J.Urolonc.2016.02.025 |
0.456 |
|
| 2016 |
Hedrick E, Cheng Y, Jin UH, Kim K, Safe S. Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells. Oncotarget. PMID 26967243 DOI: 10.18632/Oncotarget.7925 |
0.748 |
|
| 2016 |
Delgado E, Boisen MM, Laskey R, Chen R, Song C, Sallit J, Yochum ZA, Andersen CL, Sikora MJ, Wagner J, Safe S, Elishaev E, Lee A, Edwards RP, Haluska P, et al. High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome. Gynecologic Oncology. PMID 26946093 DOI: 10.1016/J.Ygyno.2016.02.030 |
0.388 |
|
| 2016 |
Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S. NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration. Molecular and Cellular Biology. PMID 26929200 DOI: 10.1128/Mcb.00912-15 |
0.359 |
|
| 2016 |
Takeuchi H, Taoka R, Jinesh GG, Mmeje CO, Safe S, Aoyagi T, Tachibana M, Kamat AM. Mp45-02 Cdoda-Me Decreases Specificity Protein Transcription Factors And Induces Apoptosis In Bladder Cancer Cells Through Induction Of Reactive Oxygen Species The Journal of Urology. 195. DOI: 10.1016/J.Juro.2016.02.279 |
0.4 |
|
| 2015 |
Li X, Pathi SS, Safe S. Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors. Bmc Cancer. 15: 974. PMID 26673922 DOI: 10.1186/S12885-015-1956-8 |
0.789 |
|
| 2015 |
Safe S. MicroRNA-Specificity Protein (Sp) Transcription Factor Interactions and Significance in Carcinogenesis. Current Pharmacology Reports. 1: 73-78. PMID 26457240 DOI: 10.1007/S40495-014-0012-8 |
0.351 |
|
| 2015 |
Hammond SL, Safe S, Tjalkens RB. A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Neuroscience Letters. 607: 83-9. PMID 26383113 DOI: 10.1016/J.Neulet.2015.09.015 |
0.334 |
|
| 2015 |
Gandhy SU, Imanirad P, Jin UH, Nair V, Hedrick E, Cheng Y, Corton JC, Kim K, Safe S. Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC. Oncotarget. PMID 26317792 DOI: 10.18632/Oncotarget.4560 |
0.743 |
|
| 2015 |
Boakye CH, Shah PP, Doddapaneni R, Patel AR, Safe S, Singh M. Enhanced Percutaneous Delivery of 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) Methane for Skin Cancer Chemoprevention. Journal of Biomedical Nanotechnology. 11: 1269-81. PMID 26307849 DOI: 10.1166/Jbn.2015.2064 |
0.303 |
|
| 2015 |
Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S. Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Breast Cancer Chemotherapy. Endocrine-Related Cancer. PMID 26229035 DOI: 10.1530/Erc-15-0063 |
0.521 |
|
| 2015 |
Riddell N, Jin UH, Safe S, Cheng Y, Chittim B, Konstantinov A, Parette R, Pena-Abaurrea M, Reiner EJ, Poirier D, Stefanac T, McAlees AJ, McCrindle R. Characterization and Biological Potency of Mono- to Tetra-Halogenated Carbazoles. Environmental Science & Technology. 49: 10658-66. PMID 26226543 DOI: 10.1021/Acs.Est.5B02751 |
0.409 |
|
| 2015 |
Hedrick E, Crose L, Linardic CM, Safe S. Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species-Dependent Targeting of Specificity Protein Transcription Factors. Molecular Cancer Therapeutics. 14: 2143-53. PMID 26162688 DOI: 10.1158/1535-7163.Mct-15-0148 |
0.396 |
|
| 2015 |
Das Gupta S, Sae-Tan S, Wahler J, So JY, Bak MJ, Cheng LC, Lee MJ, Lin Y, Shih WJ, Shull JD, Safe S, Yang CS, Suh N. Dietary γ-Tocopherol Rich Mixture Inhibits Estrogen-Induced Mammary Tumorigenesis by Modulating Estrogen Metabolism, Antioxidant Response and PPARγ. Cancer Prevention Research (Philadelphia, Pa.). PMID 26130252 DOI: 10.1158/1940-6207.Capr-15-0154 |
0.421 |
|
| 2015 |
Hedrick E, Lee SO, Kim G, Abdelrahim M, Jin UH, Safe S, Abudayyeh A. Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma. Plos One. 10: e0128308. PMID 26035713 DOI: 10.1371/Journal.Pone.0128308 |
0.477 |
|
| 2015 |
Fan YY, Davidson LA, Callaway ES, Wright GA, Safe S, Chapkin RS. A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 309: G1-9. PMID 25977509 DOI: 10.1152/Ajpgi.00052.2015 |
0.358 |
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| 2015 |
Safe S, Jin UH, Morpurgo B, Abudayyeh A, Singh M, Tjalkens RB. Nuclear receptor 4A (NR4A) family - orphans no more. The Journal of Steroid Biochemistry and Molecular Biology. PMID 25917081 DOI: 10.1016/J.Jsbmb.2015.04.016 |
0.365 |
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| 2015 |
Cheng Y, Jutooru I, Chadalapaka G, Corton JC, Safe S. The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration. Oncotarget. 6: 10840-52. PMID 25912306 DOI: 10.18632/Oncotarget.3450 |
0.762 |
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| 2015 |
Cheng Y, Jin UH, Allred CD, Jayraman A, Chapkin RS, Safe S. Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 25873348 DOI: 10.1124/Dmd.115.063677 |
0.436 |
|
| 2015 |
De Miranda BR, Popichak KA, Hammond SL, Jorgensen BA, Phillips AT, Safe S, Tjalkens RB. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB. Molecular Pharmacology. 87: 1021-34. PMID 25858541 DOI: 10.1124/Mol.114.095398 |
0.421 |
|
| 2015 |
Jin UH, Kim SB, Safe S. Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway. Chemical Research in Toxicology. 28: 907-18. PMID 25826687 DOI: 10.1021/Tx5005198 |
0.473 |
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| 2015 |
Safe S. Targeting apoptosis pathways in cancer--letter. Cancer Prevention Research (Philadelphia, Pa.). 8: 338. PMID 25627800 DOI: 10.1158/1940-6207.Capr-14-0405 |
0.389 |
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| 2015 |
De Miranda BR, Popichak KA, Hammond SL, Miller JA, Safe S, Tjalkens RB. Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease. Toxicological Sciences : An Official Journal of the Society of Toxicology. 143: 360-73. PMID 25406165 DOI: 10.1093/Toxsci/Kfu236 |
0.366 |
|
| 2015 |
Safe S, Lee SO, Meng C, Zhou B. Nr4a orphan receptors as drug targets Targeted Therapy of Acute Myeloid Leukemi. 509-528. DOI: 10.1007/978-1-4939-1393-0_26 |
0.335 |
|
| 2014 |
Yang WS, Chadalapaka G, Cho SG, Lee SO, Jin UH, Jutooru I, Choi K, Leung YK, Ho SM, Safe S, Kim K. The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis. Neoplasia (New York, N.Y.). 16: 1059-69. PMID 25499219 DOI: 10.1016/J.Neo.2014.09.011 |
0.825 |
|
| 2014 |
Nair V, Sreevalsan S, Basha R, Abdelrahim M, Abudayyeh A, Rodrigues Hoffman A, Safe S. Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors. The Journal of Biological Chemistry. 289: 27692-701. PMID 25143389 DOI: 10.1074/jbc.M114.592576 |
0.344 |
|
| 2014 |
Lee SO, Li X, Hedrick E, Jin UH, Tjalkens RB, Backos DS, Li L, Zhang Y, Wu Q, Safe S. Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells. Molecular Endocrinology (Baltimore, Md.). 28: 1729-39. PMID 25099012 DOI: 10.1210/Me.2014-1102 |
0.554 |
|
| 2014 |
Jin UH, Lee SO, Pfent C, Safe S. The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis. Bmc Cancer. 14: 498. PMID 25011475 DOI: 10.1186/1471-2407-14-498 |
0.409 |
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| 2014 |
Safe S, Imanirad P, Sreevalsan S, Nair V, Jutooru I. Transcription factor Sp1, also known as specificity protein 1 as a therapeutic target. Expert Opinion On Therapeutic Targets. 18: 759-69. PMID 24793594 DOI: 10.1517/14728222.2014.914173 |
0.744 |
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| 2014 |
Zhang Z, Kim K, Li X, Moreno M, Sharp T, Goodheart MJ, Safe S, Dupuy AJ, Amendt BA. MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression. Molecular Cancer Therapeutics. 13: 1942-51. PMID 24785257 DOI: 10.1158/1535-7163.Mct-13-1000 |
0.748 |
|
| 2014 |
Jutooru I, Guthrie AS, Chadalapaka G, Pathi S, Kim K, Burghardt R, Jin UH, Safe S. Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents. Molecular and Cellular Biology. 34: 2382-95. PMID 24732804 DOI: 10.1128/Mcb.01602-13 |
0.799 |
|
| 2014 |
Jin UH, Lee SO, Sridharan G, Lee K, Davidson LA, Jayaraman A, Chapkin RS, Alaniz R, Safe S. Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities. Molecular Pharmacology. 85: 777-88. PMID 24563545 DOI: 10.1124/Mol.113.091165 |
0.442 |
|
| 2014 |
Lee SO, Jin UH, Kang JH, Kim SB, Guthrie AS, Sreevalsan S, Lee JS, Safe S. The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Molecular Cancer Research : McR. 12: 527-38. PMID 24515801 DOI: 10.1158/1541-7786.Mcr-13-0567 |
0.448 |
|
| 2014 |
Safe S, Jin UH, Hedrick E, Reeder A, Lee SO. Minireview: role of orphan nuclear receptors in cancer and potential as drug targets. Molecular Endocrinology (Baltimore, Md.). 28: 157-72. PMID 24295738 DOI: 10.1210/Me.2013-1291 |
0.459 |
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| 2014 |
Goldberg AA, Titorenko VI, Beach A, Abdelbaqi K, Safe S, Sanderson JT. Ring-substituted analogs of 3,3'-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells. Investigational New Drugs. 32: 25-36. PMID 23709189 DOI: 10.1007/S10637-013-9979-Y |
0.401 |
|
| 2014 |
Pathi S, Li X, Safe S. Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors. Molecular Carcinogenesis. 53: E53-61. PMID 23670891 DOI: 10.1002/Mc.22010 |
0.819 |
|
| 2014 |
Abdelrahim M, Bilen MA, Safe S, Abudayyeh A. Abstract 4532: New tolfenamic acid's derivatives inhibit cancer cells growth and tumor progression: Pre-clinical studies update Cancer Research. 74: 4532-4532. DOI: 10.1158/1538-7445.Am2014-4532 |
0.488 |
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| 2014 |
Doddapaneni R, Boakye C, Shah P, Patel AR, Godugu C, Safe S, Katiyar S, Sachdeva M. Abstract 3139: Nurr1, a novel target of 1,1-bis(3’-indolyl)-1-(p-chlorophenyl) methane for inhibition of the initiation and progression of skin cancer tumorigenesis Cancer Research. 74: 3139-3139. DOI: 10.1158/1538-7445.Am2014-3139 |
0.335 |
|
| 2013 |
Sreevalsan S, Safe S. REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER. Current Colorectal Cancer Reports. 9: 350-357. PMID 25584043 DOI: 10.1007/S11888-013-0190-5 |
0.426 |
|
| 2013 |
Sreevalsan S, Safe S. The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells. Molecular Cancer Therapeutics. 12: 2483-93. PMID 24030632 DOI: 10.1158/1535-7163.Mct-13-0486 |
0.453 |
|
| 2013 |
Boakye CH, Doddapaneni R, Shah PP, Patel AR, Godugu C, Safe S, Katiyar SK, Singh M. Chemoprevention of skin cancer with 1,1-Bis (3'-indolyl)-1-(aromatic) methane analog through induction of the orphan nuclear receptor, NR4A2 (Nurr1). Plos One. 8: e69519. PMID 23950896 DOI: 10.1371/Journal.Pone.0069519 |
0.349 |
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| 2013 |
Andey T, Patel A, Jackson T, Safe S, Singh M. 1,1-Bis (3'-indolyl)-1-(p-substitutedphenyl)methane compounds inhibit lung cancer cell and tumor growth in a metastasis model. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 50: 227-41. PMID 23892137 DOI: 10.1016/J.Ejps.2013.07.007 |
0.357 |
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| 2013 |
Nair V, Pathi S, Jutooru I, Sreevalsan S, Basha R, Abdelrahim M, Samudio I, Safe S. Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors. Carcinogenesis. 34: 2870-9. PMID 23803693 DOI: 10.1093/Carcin/Bgt231 |
0.833 |
|
| 2013 |
Safe S, Lee SO, Jin UH. Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target. Toxicological Sciences : An Official Journal of the Society of Toxicology. 135: 1-16. PMID 23771949 DOI: 10.1093/Toxsci/Kft128 |
0.419 |
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| 2013 |
Bousquet M, Zhuang G, Meng C, Ying W, Cheruku PS, Shie AT, Wang S, Ge G, Wong P, Wang G, Safe S, Zhou B. miR-150 blocks MLL-AF9-associated leukemia through oncogene repression. Molecular Cancer Research : McR. 11: 912-22. PMID 23604034 DOI: 10.1158/1541-7786.Mcr-13-0002-T |
0.313 |
|
| 2013 |
Del Follo-Martinez A, Banerjee N, Li X, Safe S, Mertens-Talcott S. Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a. Nutrition and Cancer. 65: 494-504. PMID 23530649 DOI: 10.1080/01635581.2012.725194 |
0.448 |
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| 2013 |
Noratto GD, Jutooru I, Safe S, Angel-Morales G, Mertens-Talcott SU. The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis. Molecular Nutrition & Food Research. 57: 1638-48. PMID 23471840 DOI: 10.1002/Mnfr.201200609 |
0.774 |
|
| 2013 |
Shin JA, Jung JY, Ryu MH, Safe S, Cho SD. Mithramycin A inhibits myeloid cell leukemia-1 to induce apoptosis in oral squamous cell carcinomas and tumor xenograft through activation of Bax and oligomerization. Molecular Pharmacology. 83: 33-41. PMID 23019217 DOI: 10.1124/Mol.112.081364 |
0.418 |
|
| 2013 |
Chadalapaka G, Jutooru I, Sreevalsan S, Pathi S, Kim K, Chen C, Crose L, Linardic C, Safe S. Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors. International Journal of Cancer. 132: 795-806. PMID 22815231 DOI: 10.1002/Ijc.27730 |
0.823 |
|
| 2013 |
Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R, Kim S, Safe S. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene. 32: 1616-25. PMID 22614017 DOI: 10.1038/Onc.2012.193 |
0.83 |
|
| 2013 |
Mertens-Talcott SU, Noratto GD, Li X, Angel-Morales G, Bertoldi MC, Safe S. Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10. Molecular Carcinogenesis. 52: 591-602. PMID 22407812 DOI: 10.1002/Mc.21893 |
0.484 |
|
| 2013 |
Cheruku PS, Bousquet M, Zhang G, Ge G, Ying W, Meng C, Shie A, Wang S, Wong P, Wang G, Safe S, Zhou B. MiR-150 Inhibits MLL-AF9 Associated Leukemia By Suppressing Leukemic Stem Cells Blood. 122: 3764-3764. DOI: 10.1182/Blood.V122.21.3764.3764 |
0.318 |
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| 2013 |
Safe S, Jin U, Lee S. The orphan receptor NR4A1 (TR3/Nur77) as a drug target for cancer chemotherapy Toxicology Letters. 221. DOI: 10.1016/J.Toxlet.2013.06.104 |
0.336 |
|
| 2012 |
Gandhy SU, Kim K, Larsen L, Rosengren RJ, Safe S. Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs. Bmc Cancer. 12: 564. PMID 23194063 DOI: 10.1186/1471-2407-12-564 |
0.764 |
|
| 2012 |
Pathi S, Jutooru I, Chadalapaka G, Nair V, Lee SO, Safe S. Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors. Plos One. 7: e48208. PMID 23110215 DOI: 10.1371/Journal.Pone.0048208 |
0.844 |
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| 2012 |
Banerjee N, Talcott S, Safe S, Mertens-Talcott SU. Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation. Breast Cancer Research and Treatment. 136: 21-34. PMID 22941571 DOI: 10.1007/S10549-012-2224-0 |
0.453 |
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| 2012 |
Jin UH, Lee SO, Safe S. Aryl hydrocarbon receptor (AHR)-active pharmaceuticals are selective AHR modulators in MDA-MB-468 and BT474 breast cancer cells. The Journal of Pharmacology and Experimental Therapeutics. 343: 333-41. PMID 22879383 DOI: 10.1124/jpet.112.195339 |
0.402 |
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| 2012 |
Kim K, Chadalapaka G, Pathi SS, Jin UH, Lee JS, Park YY, Cho SG, Chintharlapalli S, Safe S. Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters. Molecular Cancer Therapeutics. 11: 1852-62. PMID 22752225 DOI: 10.1158/1535-7163.Mct-12-0181 |
0.817 |
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| 2012 |
Safe SH, Prather PL, Brents LK, Chadalapaka G, Jutooru I. Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs. Anti-Cancer Agents in Medicinal Chemistry. 12: 1211-20. PMID 22583404 DOI: 10.2174/187152012803833099 |
0.763 |
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| 2012 |
Liu X, Jutooru I, Lei P, Kim K, Lee SO, Brents LK, Prather PL, Safe S. Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer. Molecular Cancer Therapeutics. 11: 1421-31. PMID 22553354 DOI: 10.1158/1535-7163.Mct-12-0026 |
0.829 |
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| 2012 |
Wilson H, Chadalapaka G, Jutooru I, Sheppard S, Pfent C, Safe S. Effect of Tolfenamic Acid on Canine Cancer Cell Proliferation, Specificity Protein (Sp) Transcription Factors, and Sp-Regulated Proteins in Canine Osteosarcoma, Mammary Carcinoma, and Melanoma Cells Journal of Veterinary Internal Medicine. 26: 977-986. PMID 22536857 DOI: 10.1111/J.1939-1676.2012.00931.X |
0.771 |
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| 2012 |
Schulz VJ, Smit JJ, Huijgen V, Bol-Schoenmakers M, van Roest M, Kruijssen LJ, Fiechter D, Hassing I, Bleumink R, Safe S, van Duursen MB, van den Berg M, Pieters RH. Non-dioxin-like AhR ligands in a mouse peanut allergy model. Toxicological Sciences : An Official Journal of the Society of Toxicology. 128: 92-102. PMID 22491429 DOI: 10.1093/Toxsci/Kfs131 |
0.327 |
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| 2012 |
Sankpal UT, Abdelrahim M, Connelly SF, Lee CM, Madero-Visbal R, Colon J, Smith J, Safe S, Maliakal P, Basha R. Small molecule tolfenamic acid inhibits PC-3 cell proliferation and invasion in vitro, and tumor growth in orthotopic mouse model for prostate cancer. The Prostate. 72: 1648-58. PMID 22473873 DOI: 10.1002/Pros.22518 |
0.423 |
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| 2012 |
Li X, Lee SO, Safe S. Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3'-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells. Biochemical Pharmacology. 83: 1445-55. PMID 22405837 DOI: 10.1016/J.Bcp.2012.02.021 |
0.459 |
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| 2012 |
Chadalapaka G, Jutooru I, Safe S. Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells. Carcinogenesis. 33: 886-94. PMID 22334592 DOI: 10.1093/Carcin/Bgs102 |
0.782 |
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| 2012 |
Park YY, Kim K, Kim SB, Hennessy BT, Kim SM, Park ES, Lim JY, Li J, Lu Y, Gonzalez-Angulo AM, Jeong W, Mills GB, Safe S, Lee JS. Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer. Embo Molecular Medicine. 4: 52-67. PMID 22174013 DOI: 10.1002/Emmm.201100187 |
0.751 |
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| 2012 |
Lee SO, Andey T, Jin UH, Kim K, Singh M, Sachdeva M, Safe S. The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53. Oncogene. 31: 3265-76. PMID 22081070 DOI: 10.1038/Onc.2011.504 |
0.765 |
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| 2012 |
Zhang S, Kim K, Jin UH, Pfent C, Cao H, Amendt B, Liu X, Wilson-Robles H, Safe S. Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells. Molecular Cancer Therapeutics. 11: 108-18. PMID 22034498 DOI: 10.1158/1535-7163.Mct-11-0548 |
0.726 |
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| 2012 |
Li Z, Chadalapaka G, Ramesh A, Khoshbouei H, Maguire M, Safe S, Rhoades RE, Clark R, Jules G, McCallister M, Aschner M, Hood DB. PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. Toxicological Sciences : An Official Journal of the Society of Toxicology. 125: 233-47. PMID 21987461 DOI: 10.1093/Toxsci/Kfr261 |
0.303 |
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| 2012 |
Kim K, Chadalapaka G, Lee SO, Yamada D, Sastre-Garau X, Defossez PA, Park YY, Lee JS, Safe S. Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer. Oncogene. 31: 1034-44. PMID 21765466 DOI: 10.1038/Onc.2011.296 |
0.721 |
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| 2012 |
Maliakal P, Abdelrahim M, Sankpal UT, Maliakal C, Baker CH, Safe S, Herrera LJ, Abudayyeh A, Kaja S, Basha R. Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats. Investigational New Drugs. 30: 853-61. PMID 21197621 DOI: 10.1007/S10637-010-9622-0 |
0.372 |
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| 2012 |
Yao C, Safe S. The interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in chick embryo hepatocytes. Toxicology in Vitro : An International Journal Published in Association With Bibra. 6: 373-80. PMID 20732135 DOI: 10.1016/0887-2333(92)90028-P |
0.305 |
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| 2012 |
Patel AR, Lim E, Zhang N, Francis K, Safe S, Sachdeva M. Abstract 382: In-vivo imaging of lung cancer using tumor homing peptide coated nanoparticles Cancer Research. 72: 382-382. DOI: 10.1158/1538-7445.Am2012-382 |
0.345 |
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| 2012 |
Singh M, Andey T, Singh S, Patel AR, Godugu C, Safe S, Chellappan S. Abstract 3361: Sensitization of chemoresistant H1650 lung cancer stem cells to chemotherapy by combination treatment with novel diindolylmethane compounds Cancer Research. 72: 3361-3361. DOI: 10.1158/1538-7445.Am2012-3361 |
0.407 |
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| 2012 |
Kim K, Safe S. Abstract 203: Hotair, a long non-coding RNA, exhibits pro-oncogenic activity in pancreatic cancer Cancer Research. 72: 203-203. DOI: 10.1158/1538-7445.Am2012-203 |
0.688 |
|
| 2011 |
Sreevalsan S, Joseph S, Jutooru I, Chadalapaka G, Safe SH. Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent. Anticancer Research. 31: 3799-807. PMID 22110202 |
0.731 |
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| 2011 |
Pathi SS, Lei P, Sreevalsan S, Chadalapaka G, Jutooru I, Safe S. Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells. Nutrition and Cancer. 63: 1133-42. PMID 21919647 DOI: 10.1080/01635581.2011.605984 |
0.844 |
|
| 2011 |
Chintharlapalli S, Papineni S, Lei P, Pathi S, Safe S. Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors. Bmc Cancer. 11: 371. PMID 21864401 DOI: 10.1186/1471-2407-11-371 |
0.836 |
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| 2011 |
Shin JA, Shim JH, Choi ES, Leem DH, Kwon KH, Lee SO, Safe S, Cho NP, Cho SD. Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (Ecp). 20: 417-25. PMID 21597379 DOI: 10.1097/Cej.0B013E32834473C3 |
0.407 |
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| 2011 |
Yoon K, Lee SO, Cho SD, Kim K, Khan S, Safe S. Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors. Carcinogenesis. 32: 836-42. PMID 21362629 DOI: 10.1093/Carcin/Bgr040 |
0.812 |
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| 2011 |
Abdelbaqi K, Lack N, Guns ET, Kotha L, Safe S, Sanderson JT. Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells. The Prostate. 71: 1401-12. PMID 21321979 DOI: 10.1002/Pros.21356 |
0.795 |
|
| 2011 |
Chintharlapalli S, Papineni S, Lee SO, Lei P, Jin UH, Sherman SI, Santarpia L, Safe S. Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins. Molecular Carcinogenesis. 50: 655-67. PMID 21268135 DOI: 10.1002/Mc.20738 |
0.838 |
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| 2011 |
Lee SO, Li X, Khan S, Safe S. Targeting NR4A1 (TR3) in cancer cells and tumors. Expert Opinion On Therapeutic Targets. 15: 195-206. PMID 21204731 DOI: 10.1517/14728222.2011.547481 |
0.649 |
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| 2011 |
Basha R, Baker CH, Sankpal UT, Ahmad S, Safe S, Abbruzzese JL, Abdelrahim M. Therapeutic applications of NSAIDS in cancer: special emphasis on tolfenamic acid. Frontiers in Bioscience (Scholar Edition). 3: 797-805. PMID 21196413 DOI: 10.2741/S188 |
0.322 |
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| 2011 |
Kim K, Burghardt R, Barhoumi R, Lee SO, Liu X, Safe S. MDM2 regulates estrogen receptor α and estrogen responsiveness in breast cancer cells. Journal of Molecular Endocrinology. 46: 67-79. PMID 21169420 DOI: 10.1677/Jme-10-0110 |
0.755 |
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| 2011 |
Pathi SS, Jutooru I, Chadalapaka G, Sreevalsan S, Anand S, Thatcher GR, Safe S. GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. Molecular Cancer Research : McR. 9: 195-202. PMID 21156786 DOI: 10.1158/1541-7786.Mcr-10-0363 |
0.838 |
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| 2011 |
Colon J, Basha MR, Madero-Visbal R, Konduri S, Baker CH, Herrera LJ, Safe S, Sheikh-Hamad D, Abudayyeh A, Alvarado B, Abdelrahim M. Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice. Investigational New Drugs. 29: 41-51. PMID 19851711 DOI: 10.1007/S10637-009-9331-8 |
0.453 |
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| 2011 |
Lee S, Andey T, Jin U, Kim K, Singh M, Safe S. Abstract 4009: Regulation of mTOR pathway by the orphan nuclear receptor NR4A1 (TR3/Nur77) in non-small cell lung cancer: Role of TR3 in AMPK activation Cellular and Molecular Biology. 71: 4009-4009. DOI: 10.1158/1538-7445.Am2011-4009 |
0.729 |
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| 2011 |
Park Y, Kim K, Kim S, Hennessy B, Kim SM, Park ES, Lim JY, Li J, Lu Y, Gonzalez-Angulo A, Mills G, Safe S, Lee J. Abstract 356: Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer Cancer Research. 71: 356-356. DOI: 10.1158/1538-7445.Am2011-356 |
0.444 |
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| 2010 |
Vanderlaag K, Su Y, Frankel AE, Burghardt RC, Barhoumi R, Chadalapaka G, Jutooru I, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer. Bmc Cancer. 10: 669. PMID 21129193 DOI: 10.1186/1471-2407-10-669 |
0.78 |
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| 2010 |
Ichite N, Chougule M, Patel AR, Jackson T, Safe S, Singh M. Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer. Molecular Cancer Therapeutics. 9: 3003-14. PMID 20978159 DOI: 10.1158/1535-7163.Mct-09-1104 |
0.335 |
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| 2010 |
Ortholan C, Durivault J, Hannoun-Levi JM, Guyot M, Bourcier C, Ambrosetti D, Safe S, Pagès G. Bevacizumab/docetaxel association is more efficient than docetaxel alone in reducing breast and prostate cancer cell growth: a new paradigm for understanding the therapeutic effect of combined treatment. European Journal of Cancer (Oxford, England : 1990). 46: 3022-36. PMID 20729074 DOI: 10.1016/J.Ejca.2010.07.021 |
0.387 |
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| 2010 |
Lee SO, Abdelrahim M, Yoon K, Chintharlapalli S, Papineni S, Kim K, Wang H, Safe S. Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth. Cancer Research. 70: 6824-36. PMID 20660371 DOI: 10.1158/0008-5472.Can-10-1992 |
0.836 |
|
| 2010 |
Safe S. 3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters. Toxicological Sciences : An Official Journal of the Society of Toxicology. 117: 1-3. PMID 20651249 DOI: 10.1093/Toxsci/Kfq193 |
0.42 |
|
| 2010 |
Pang X, Zhang L, Wu Y, Lin L, Li J, Qu W, Safe S, Liu M. Methyl 2-cyano-3,11-dioxo-18-olean-1,12-dien-30-oate (CDODA-Me), a derivative of glycyrrhetinic acid, functions as a potent angiogenesis inhibitor. The Journal of Pharmacology and Experimental Therapeutics. 335: 172-9. PMID 20631299 DOI: 10.1124/Jpet.110.171066 |
0.417 |
|
| 2010 |
Jutooru I, Chadalapaka G, Lei P, Safe S. Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. The Journal of Biological Chemistry. 285: 25332-44. PMID 20538607 DOI: 10.1074/Jbc.M109.095240 |
0.798 |
|
| 2010 |
Tsao T, Kornblau S, Safe S, Watt JC, Ruvolo V, Chen W, Qiu Y, Coombes KR, Ju Z, Abdelrahim M, Schober W, Ling X, Kardassis D, Meyer C, Schimmer A, et al. Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia. Cancer Research. 70: 4949-60. PMID 20501850 DOI: 10.1158/0008-5472.Can-09-1962 |
0.452 |
|
| 2010 |
Jutooru I, Chadalapaka G, Abdelrahim M, Basha MR, Samudio I, Konopleva M, Andreeff M, Safe S. Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a. Molecular Pharmacology. 78: 226-36. PMID 20488920 DOI: 10.1124/Mol.110.064451 |
0.833 |
|
| 2010 |
Jutooru I, Chadalapaka G, Sreevalsan S, Lei P, Barhoumi R, Burghardt R, Safe S. Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Experimental Cell Research. 316: 2174-88. PMID 20435036 DOI: 10.1016/J.Yexcr.2010.04.027 |
0.793 |
|
| 2010 |
Chadalapaka G, Jutooru I, Burghardt R, Safe S. Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells. Molecular Cancer Research : McR. 8: 739-50. PMID 20407012 DOI: 10.1158/1541-7786.Mcr-09-0493 |
0.777 |
|
| 2010 |
Li X, Mertens-Talcott SU, Zhang S, Kim K, Ball J, Safe S. MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells. Endocrinology. 151: 2462-73. PMID 20382698 DOI: 10.1210/En.2009-1150 |
0.728 |
|
| 2010 |
Cho SD, Lee SO, Chintharlapalli S, Abdelrahim M, Khan S, Yoon K, Kamat AM, Safe S. Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth. Molecular Pharmacology. 77: 396-404. PMID 20023005 DOI: 10.1124/Mol.109.061143 |
0.797 |
|
| 2010 |
Choi KH, Kim HK, Kim JH, Choi ES, Shin JA, Lee SO, Chintharlapalli S, Safe S, Abdelrahim M, Kong G, Choi HS, Jung JY, Cho HT, Cho NP, Cho SD. The p38 MAPK pathway is critical for 5,5'-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (Ecp). 19: 153-9. PMID 19949342 DOI: 10.1097/Cej.0B013E328333D088 |
0.731 |
|
| 2010 |
Guo J, Chintharlapalli S, Lee SO, Cho SD, Lei P, Papineni S, Safe S. Peroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells. Cancer Chemotherapy and Pharmacology. 66: 141-50. PMID 19823826 DOI: 10.1007/S00280-009-1144-0 |
0.818 |
|
| 2010 |
Mahammad RB, Madero-Visbal R, Baker CH, Colon J, Safe S, Abudayyeh A, Abdelrahim M. Abstract 4075: Tolfenamic Acid Inhibits Prostate Cancer Cells Growth and Tumor Development in Orthotopic Mice Cancer Research. 70: 4075-4075. DOI: 10.1158/1538-7445.Am10-4075 |
0.469 |
|
| 2009 |
Sreevalsan S, Jutooru I, Chadalapaka G, Walker M, Safe S. 1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells. International Journal of Oncology. 35: 1191-9. PMID 19787275 DOI: 10.3892/Ijo_00000436 |
0.762 |
|
| 2009 |
Lee SO, Chintharlapalli S, Liu S, Papineni S, Cho SD, Yoon K, Safe S. p21 expression is induced by activation of nuclear nerve growth factor-induced Balpha (Nur77) in pancreatic cancer cells. Molecular Cancer Research : McR. 7: 1169-78. PMID 19584258 DOI: 10.1158/1541-7786.Mcr-08-0473 |
0.842 |
|
| 2009 |
Chintharlapalli S, Papineni S, Abdelrahim M, Abudayyeh A, Jutooru I, Chadalapaka G, Wu F, Mertens-Talcott S, Vanderlaag K, Cho SD, Smith R, Safe S. Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells. International Journal of Cancer. 125: 1965-74. PMID 19582879 DOI: 10.1002/Ijc.24530 |
0.817 |
|
| 2009 |
Zhang S, Lei P, Liu X, Li X, Walker K, Kotha L, Rowlands C, Safe S. The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy. Endocrine-Related Cancer. 16: 835-44. PMID 19447902 DOI: 10.1677/Erc-09-0054 |
0.845 |
|
| 2009 |
Liu X, Abdelrahim M, Abudayyeh A, Lei P, Safe S. The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression. Molecular Cancer Therapeutics. 8: 1207-17. PMID 19435870 DOI: 10.1158/1535-7163.Mct-08-1097 |
0.503 |
|
| 2009 |
Papineni S, Chintharlapalli S, Abdelrahim M, Lee SO, Burghardt R, Abudayyeh A, Baker C, Herrera L, Safe S. Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met. Carcinogenesis. 30: 1193-201. PMID 19406933 DOI: 10.1093/Carcin/Bgp092 |
0.845 |
|
| 2009 |
Konduri S, Colon J, Baker CH, Safe S, Abbruzzese JL, Abudayyeh A, Basha MR, Abdelrahim M. Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression. Molecular Cancer Therapeutics. 8: 533-42. PMID 19258429 DOI: 10.1158/1535-7163.Mct-08-0405 |
0.396 |
|
| 2009 |
Barhoumi R, Catania JM, Parrish AR, Awooda I, Tiffany-Castiglioni E, Safe S, Burghardt RC. Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines. The Journal of Toxicological Sciences. 34: 13-25. PMID 19182432 DOI: 10.2131/Jts.34.13 |
0.321 |
|
| 2009 |
Ichite N, Chougule MB, Jackson T, Fulzele SV, Safe S, Singh M. Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 543-52. PMID 19147759 DOI: 10.1158/1078-0432.Ccr-08-1558 |
0.388 |
|
| 2009 |
Jutooru I, Chadalapaka G, Chintharlapalli S, Papineni S, Safe S. Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative. Molecular Carcinogenesis. 48: 692-702. PMID 19125423 DOI: 10.1002/Mc.20518 |
0.84 |
|
| 2009 |
Wu F, Ivanov I, Xu R, Safe S. Role of SP transcription factors in hormone-dependent modulation of genes in MCF-7 breast cancer cells: microarray and RNA interference studies. Journal of Molecular Endocrinology. 42: 19-33. PMID 18952783 DOI: 10.1677/Jme-08-0088 |
0.485 |
|
| 2009 |
Carbone DL, Popichak KA, Moreno JA, Safe S, Tjalkens RB. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis. Molecular Pharmacology. 75: 35-43. PMID 18840677 DOI: 10.1124/Mol.108.050781 |
0.343 |
|
| 2008 |
Inamoto T, Papineni S, Chintharlapalli S, Cho SD, Safe S, Kamat AM. 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Molecular Cancer Therapeutics. 7: 3825-33. PMID 19074857 DOI: 10.1158/1535-7163.Mct-08-0730 |
0.838 |
|
| 2008 |
Lee SH, Bahn JH, Choi CK, Whitlock NC, English AE, Safe S, Baek SJ. ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells. Molecular Cancer Therapeutics. 7: 3739-50. PMID 19074849 DOI: 10.1158/1535-7163.Mct-08-0548 |
0.44 |
|
| 2008 |
Lei P, Abdelrahim M, Cho SD, Liu X, Liu X, Safe S. Structure-dependent activation of endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer by 1,1-bis(3'-indoly)-1-(p-substituted phenyl)methanes. Molecular Cancer Therapeutics. 7: 3363-72. PMID 18852139 DOI: 10.1158/1535-7163.Mct-08-0439 |
0.481 |
|
| 2008 |
Safe S, Kim K, Kim K. Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways. Journal of Molecular Endocrinology. 41: 263-75. PMID 18772268 DOI: 10.1677/Jme-08-0103 |
0.744 |
|
| 2008 |
Cho SD, Chintharlapalli S, Abdelrahim M, Papineni S, Liu S, Guo J, Lei P, Abudayyeh A, Safe S. 5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells. Molecular Cancer Therapeutics. 7: 2109-20. PMID 18645021 DOI: 10.1158/1535-7163.Mct-07-2311 |
0.829 |
|
| 2008 |
Wu F, Xu R, Kim K, Martin J, Safe S. In vivo profiling of estrogen receptor/specificity protein-dependent transactivation. Endocrinology. 149: 5696-705. PMID 18635651 DOI: 10.1210/En.2008-0720 |
0.767 |
|
| 2008 |
Chadalapaka G, Jutooru I, Chintharlapalli S, Papineni S, Smith R, Li X, Safe S. Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Research. 68: 5345-54. PMID 18593936 DOI: 10.1158/0008-5472.Can-07-6805 |
0.841 |
|
| 2008 |
Safe S, Papineni S, Chintharlapalli S. Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs. Cancer Letters. 269: 326-38. PMID 18501502 DOI: 10.1016/J.Canlet.2008.04.021 |
0.844 |
|
| 2008 |
Lei P, Abdelrahim M, Cho SD, Liu S, Chintharlapalli S, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase. Carcinogenesis. 29: 1139-47. PMID 18460448 DOI: 10.1093/Carcin/Bgn103 |
0.737 |
|
| 2008 |
Wu F, Khan S, Wu Q, Barhoumi R, Burghardt R, Safe S. Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens. The Journal of Steroid Biochemistry and Molecular Biology. 110: 104-15. PMID 18400491 DOI: 10.1016/J.Jsbmb.2008.02.008 |
0.705 |
|
| 2008 |
Chadalapaka G, Jutooru I, McAlees A, Stefanac T, Safe S. Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. Bioorganic & Medicinal Chemistry Letters. 18: 2633-9. PMID 18359628 DOI: 10.1016/J.Bmcl.2008.03.031 |
0.741 |
|
| 2008 |
Hong J, Samudio I, Chintharlapalli S, Safe S. 1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines. Molecular Carcinogenesis. 47: 492-507. PMID 18085536 DOI: 10.1002/Mc.20407 |
0.779 |
|
| 2008 |
Zhang S, Rowlands C, Safe S. Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay. Toxicology and Applied Pharmacology. 227: 196-206. PMID 18048071 DOI: 10.1016/J.Taap.2007.10.019 |
0.488 |
|
| 2008 |
Tjalkens RB, Liu X, Mohl B, Wright T, Moreno JA, Carbone DL, Safe S. The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells. Journal of Neuroscience Research. 86: 618-29. PMID 18041089 DOI: 10.1002/Jnr.21524 |
0.4 |
|
| 2008 |
York M, Abdelrahim M, Chintharlapalli S, Lucero SD, Safe S. 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce apoptosis and inhibit renal cell carcinoma growth. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 6743-52. PMID 18006776 DOI: 10.1158/1078-0432.Ccr-07-0967 |
0.718 |
|
| 2008 |
Higgins KJ, Liu S, Abdelrahim M, Vanderlaag K, Liu X, Porter W, Metz R, Safe S. Vascular endothelial growth factor receptor-2 expression is down-regulated by 17beta-estradiol in MCF-7 breast cancer cells by estrogen receptor alpha/Sp proteins. Molecular Endocrinology (Baltimore, Md.). 22: 388-402. PMID 18006642 DOI: 10.1210/Me.2007-0319 |
0.847 |
|
| 2008 |
Papineni S, Chintharlapalli S, Safe S. Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate is a peroxisome proliferator-activated receptor-gamma agonist that induces receptor-independent apoptosis in LNCaP prostate cancer cells. Molecular Pharmacology. 73: 553-65. PMID 17989348 DOI: 10.1124/Mol.107.041285 |
0.82 |
|
| 2008 |
Cho SD, Lei P, Abdelrahim M, Yoon K, Liu S, Guo J, Papineni S, Chintharlapalli S, Safe S. 1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells. Molecular Carcinogenesis. 47: 252-63. PMID 17957723 DOI: 10.1002/Mc.20378 |
0.827 |
|
| 2008 |
Vanderlaag K, Su Y, Frankel AE, Grage H, Smith R, Khan S, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways. Breast Cancer Research and Treatment. 109: 273-83. PMID 17624585 DOI: 10.1007/S10549-007-9648-Y |
0.697 |
|
| 2008 |
Lei P, Abdelrahim M, Cho SD, Liu X, Safe S. Structure-dependent activation of endoplasmic reticulum stress_mediated apoptosis in pancreatic cancer by 1,1-bis(3′-indoly)-1-(p_substituted phenyl)methanes (Molecular Cancer Therapeutics (2008) 7, (3363-3372)) Molecular Cancer Therapeutics. 7. DOI: 10.1158/1535-7163.Mct-7-11-Cor4 |
0.385 |
|
| 2007 |
Mertens-Talcott SU, Chintharlapalli S, Li X, Safe S. The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Research. 67: 11001-11. PMID 18006846 DOI: 10.1158/0008-5472.Can-07-2416 |
0.721 |
|
| 2007 |
Khan S, Wu F, Liu S, Wu Q, Safe S. Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells. Journal of Molecular Endocrinology. 39: 289-304. PMID 17909268 DOI: 10.1677/Jme-07-0043 |
0.724 |
|
| 2007 |
Su Y, Vanderlaag K, Ireland C, Ortiz J, Grage H, Safe S, Frankel AE. 1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice. Breast Cancer Research : Bcr. 9: R56. PMID 17764562 DOI: 10.1186/Bcr1761 |
0.832 |
|
| 2007 |
Chintharlapalli S, Papineni S, Liu S, Jutooru I, Chadalapaka G, Cho SD, Murthy RS, You Y, Safe S. 2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells. Carcinogenesis. 28: 2337-46. PMID 17724373 DOI: 10.1093/Carcin/Bgm189 |
0.833 |
|
| 2007 |
Khan S, Liu S, Stoner M, Safe S. Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells Toxicology and Applied Pharmacology. 223: 28-38. PMID 17599377 DOI: 10.1016/J.Taap.2007.05.010 |
0.852 |
|
| 2007 |
Reddivari L, Vanamala J, Chintharlapalli S, Safe SH, Miller JC. Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways. Carcinogenesis. 28: 2227-35. PMID 17522067 DOI: 10.1093/Carcin/Bgm117 |
0.682 |
|
| 2007 |
Chintharlapalli S, Papineni S, Jutooru I, McAlees A, Safe S. Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells. Molecular Cancer Therapeutics. 6: 1588-98. PMID 17513608 DOI: 10.1158/1535-7163.Mct-07-0022 |
0.835 |
|
| 2007 |
Abdelrahim M, Baker CH, Abbruzzese JL, Sheikh-Hamad D, Liu S, Cho SD, Yoon K, Safe S. Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells. Cancer Research. 67: 3286-94. PMID 17409437 DOI: 10.1158/0008-5472.Can-06-3831 |
0.496 |
|
| 2007 |
Chintharlapalli S, Papineni S, Ramaiah SK, Safe S. Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer Research. 67: 2816-23. PMID 17363604 DOI: 10.1158/0008-5472.Can-06-3735 |
0.825 |
|
| 2007 |
Lee J, Safe S. Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150). Archives of Biochemistry and Biophysics. 461: 200-10. PMID 17306756 DOI: 10.1016/J.Abb.2006.12.030 |
0.461 |
|
| 2007 |
Cho SD, Yoon K, Chintharlapalli S, Abdelrahim M, Lei P, Hamilton S, Khan S, Ramaiah SK, Safe S. Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways. Cancer Research. 67: 674-83. PMID 17234778 DOI: 10.1158/0008-5472.Can-06-2907 |
0.802 |
|
| 2007 |
Wu F, Safe S. Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 103: 1-9. PMID 17141713 DOI: 10.1016/J.Jsbmb.2006.07.007 |
0.465 |
|
| 2007 |
Chintharlapalli S, Papineni S, Safe S. 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes inhibit growth, induce apoptosis, and decrease the androgen receptor in LNCaP prostate cancer cells through peroxisome proliferator-activated receptor gamma-independent pathways. Molecular Pharmacology. 71: 558-69. PMID 17093136 DOI: 10.1124/Mol.106.028696 |
0.832 |
|
| 2006 |
Lei P, Abdelrahim M, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit ovarian cancer cell growth through peroxisome proliferator-activated receptor-dependent and independent pathways. Molecular Cancer Therapeutics. 5: 2324-36. PMID 16985067 DOI: 10.1158/1535-7163.Mct-06-0184 |
0.5 |
|
| 2006 |
Liu S, Abdelrahim M, Khan S, Ariazi E, Jordan VC, Safe S. Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells. Biological Chemistry. 387: 1209-13. PMID 16972788 DOI: 10.1515/Bc.2006.149 |
0.677 |
|
| 2006 |
Van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, Feeley M, Fiedler H, Hakansson H, Hanberg A, Haws L, Rose M, Safe S, Schrenk D, Tohyama C, Tritscher A, et al. The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicological Sciences : An Official Journal of the Society of Toxicology. 93: 223-41. PMID 16829543 DOI: 10.1093/Toxsci/Kfl055 |
0.305 |
|
| 2006 |
Safe S, Papineni S. The role of xenoestrogenic compounds in the development of breast cancer. Trends in Pharmacological Sciences. 27: 447-54. PMID 16822555 DOI: 10.1016/J.Tips.2006.06.006 |
0.729 |
|
| 2006 |
Abdelrahim M, Baker CH, Abbruzzese JL, Safe S. Tolfenamic Acid and Pancreatic Cancer Growth, Angiogenesis, and Sp Protein Degradation Journal of the National Cancer Institute. 98: 855-868. PMID 16788159 DOI: 10.1093/Jnci/Djj232 |
0.456 |
|
| 2006 |
Khan S, Konstantinov A, Chittim B, McAlees A, Yeo B, Safe S. Structure-dependent Ah receptor agonist activities of chlorinated biphenylenes. Toxicology in Vitro : An International Journal Published in Association With Bibra. 20: 1234-7. PMID 16759834 DOI: 10.1016/J.Tiv.2006.04.003 |
0.705 |
|
| 2006 |
Chintharlapalli S, Papineni S, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways. Molecular Cancer Therapeutics. 5: 1362-70. PMID 16731770 DOI: 10.1158/1535-7163.Mct-06-0002 |
0.845 |
|
| 2006 |
Higgins KJ, Abdelrahim M, Liu S, Yoon K, Safe S. Regulation of vascular endothelial growth factor receptor-2 expression in pancreatic cancer cells by Sp proteins. Biochemical and Biophysical Research Communications. 345: 292-301. PMID 16678129 DOI: 10.1016/J.Bbrc.2006.04.111 |
0.832 |
|
| 2006 |
Khan S, Barhoumi R, Burghardt R, Liu S, Kim K, Safe S. Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells. Molecular Endocrinology (Baltimore, Md.). 20: 2199-214. PMID 16675542 DOI: 10.1210/Me.2006-0100 |
0.828 |
|
| 2006 |
Ru Lee W, Chen CC, Liu S, Safe S. 17beta-estradiol (E2) induces cdc25A gene expression in breast cancer cells by genomic and non-genomic pathways. Journal of Cellular Biochemistry. 99: 209-20. PMID 16598773 DOI: 10.1002/Jcb.20902 |
0.687 |
|
| 2006 |
Higgins KJ, Liu S, Abdelrahim M, Yoon K, Vanderlaag K, Porter W, Metz RP, Safe S. Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins. Endocrinology. 147: 3285-95. PMID 16574784 DOI: 10.1210/En.2006-0081 |
0.843 |
|
| 2006 |
Konopleva M, Zhang W, Shi YX, McQueen T, Tsao T, Abdelrahim M, Munsell MF, Johansen M, Yu D, Madden T, Safe SH, Hung MC, Andreeff M. Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells. Molecular Cancer Therapeutics. 5: 317-28. PMID 16505105 DOI: 10.1158/1535-7163.Mct-05-0350 |
0.374 |
|
| 2006 |
Abdelrahim M, Ariazi E, Kim K, Khan S, Barhoumi R, Burghardt R, Liu S, Hill D, Finnell R, Wlodarczyk B, Jordan VC, Safe S. 3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha. Cancer Research. 66: 2459-67. PMID 16489053 DOI: 10.1158/0008-5472.Can-05-3132 |
0.786 |
|
| 2006 |
Li X, Zhang S, Safe S. Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds. The Journal of Steroid Biochemistry and Molecular Biology. 98: 122-32. PMID 16413991 DOI: 10.1016/J.Jsbmb.2005.08.018 |
0.373 |
|
| 2006 |
Kassouf W, Chintharlapalli S, Abdelrahim M, Nelkin G, Safe S, Kamat AM. Inhibition of bladder tumor growth by 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes: a new class of peroxisome proliferator-activated receptor gamma agonists. Cancer Research. 66: 412-8. PMID 16397256 DOI: 10.1158/0008-5472.Can-05-2755 |
0.739 |
|
| 2006 |
Samudio I, Konopleva M, Safe S, McQueen T, Andreeff M. Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure. Molecular Cancer Therapeutics. 4: 1982-92. PMID 16373713 DOI: 10.1158/1535-7163.Mct-05-0247 |
0.631 |
|
| 2006 |
Abdelrahim M, Newman K, Vanderlaag K, Samudio I, Safe S. 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. Carcinogenesis. 27: 717-28. PMID 16332727 DOI: 10.1093/Carcin/Bgi270 |
0.698 |
|
| 2006 |
Mitchell DC, Abdelrahim M, Weng J, Stafford LJ, Safe S, Bar-Eli M, Liu M. Regulation of KiSS-1 metastasis suppressor gene expression in breast cancer cells by direct interaction of transcription factors activator protein-2alpha and specificity protein-1. The Journal of Biological Chemistry. 281: 51-8. PMID 16260418 DOI: 10.1074/Jbc.M506245200 |
0.448 |
|
| 2005 |
Lee SH, Yamaguchi K, Kim JS, Eling TE, Safe S, Park Y, Baek SJ. Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. Carcinogenesis. 27: 972-81. PMID 16286461 DOI: 10.1093/Carcin/Bgi268 |
0.409 |
|
| 2005 |
Fleming JG, Spencer TE, Safe SH, Bazer FW. Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements. Endocrinology. 147: 899-911. PMID 16254027 DOI: 10.1210/En.2005-1120 |
0.345 |
|
| 2005 |
Safe S, Abdelrahim M. Sp transcription factor family and its role in cancer. European Journal of Cancer (Oxford, England : 1990). 41: 2438-48. PMID 16209919 DOI: 10.1016/J.Ejca.2005.08.006 |
0.423 |
|
| 2005 |
Calabrò P, Samudio I, Safe SH, Willerson JT, Yeh ET. Inhibition of tumor-necrosis-factor-alpha induced endothelial cell activation by a new class of PPAR-gamma agonists. An in vitro study showing receptor-independent effects. Journal of Vascular Research. 42: 509-16. PMID 16155367 DOI: 10.1159/000088260 |
0.616 |
|
| 2005 |
Chintharlapalli S, Papineni S, Baek SJ, Liu S, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1. Molecular Pharmacology. 68: 1782-92. PMID 16155208 DOI: 10.1124/Mol.105.017046 |
0.843 |
|
| 2005 |
Samudio I, Konopleva M, Hail N, Shi YX, McQueen T, Hsu T, Evans R, Honda T, Gribble GW, Sporn M, Gilbert HF, Safe S, Andreeff M. 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. The Journal of Biological Chemistry. 280: 36273-82. PMID 16118208 DOI: 10.1074/Jbc.M507518200 |
0.638 |
|
| 2005 |
Vanderlaag K, Samudio I, Burghardt R, Barhoumi R, Safe S. Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM. Cancer Letters. 236: 198-212. PMID 16051428 DOI: 10.1016/J.Canlet.2005.05.036 |
0.697 |
|
| 2005 |
Abdelrahim M, Safe S. Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins. Molecular Pharmacology. 68: 317-29. PMID 15883203 DOI: 10.1124/mol.105.011825 |
0.364 |
|
| 2005 |
Chintharlapalli S, Burghardt R, Papineni S, Ramaiah S, Yoon K, Safe S. Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. The Journal of Biological Chemistry. 280: 24903-14. PMID 15871945 DOI: 10.1074/Jbc.M500107200 |
0.849 |
|
| 2005 |
Safe S. Clinical correlates of environmental endocrine disruptors. Trends in Endocrinology and Metabolism: Tem. 16: 139-44. PMID 15860409 DOI: 10.1016/J.Tem.2005.03.004 |
0.306 |
|
| 2005 |
Contractor R, Samudio IJ, Estrov Z, Harris D, McCubrey JA, Safe SH, Andreeff M, Konopleva M. A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia. Cancer Research. 65: 2890-8. PMID 15805291 DOI: 10.1158/0008-5472.Can-04-3781 |
0.649 |
|
| 2005 |
Chintharlapalli S, Papineni S, Konopleva M, Andreef M, Samudio I, Safe S. 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways. Molecular Pharmacology. 68: 119-28. PMID 15798084 DOI: 10.1124/Mol.105.011437 |
0.843 |
|
| 2005 |
Abdelrahim M, Liu S, Safe S. Induction of endoplasmic reticulum-induced stress genes in Panc-1 pancreatic cancer cells is dependent on Sp proteins. The Journal of Biological Chemistry. 280: 16508-13. PMID 15760841 DOI: 10.1074/Jbc.C500030200 |
0.433 |
|
| 2005 |
Kim K, Barhoumi R, Burghardt R, Safe S. Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer. Molecular Endocrinology (Baltimore, Md.). 19: 843-54. PMID 15637147 DOI: 10.1210/Me.2004-0326 |
0.771 |
|
| 2005 |
Lee JE, Kim K, Sacchettini JC, Smith CV, Safe S. DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs. The Journal of Biological Chemistry. 280: 8819-30. PMID 15625066 DOI: 10.1074/Jbc.M413184200 |
0.747 |
|
| 2005 |
Samudio I, Konopleva M, Safe S, Andreeff M. Guggulsterones Induce Apoptosis and Differentiation in AML: Identification of Isomer-Specific Antileukemic Activities of the Pregnanedienedione Structure. Blood. 106: 4466-4466. DOI: 10.1182/Blood.V106.11.4466.4466 |
0.646 |
|
| 2005 |
Kassouf W, Safe S, Abdelrahim M, Chintharlapalli S, Nelkin GM, Kamat AM. 778: Activity of Novel Agonists of Peroxisome Proliferator-Activated Receptor Gamma (Ppargamma) Against Human Transitional Cell Tumors Journal of Urology. 173: 211-211. DOI: 10.1016/S0022-5347(18)34947-4 |
0.695 |
|
| 2004 |
Fretland AJ, Safe S, Hankinson O. Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c1c7. Chemico-Biological Interactions. 150: 161-70. PMID 15535986 DOI: 10.1016/J.Cbi.2004.09.007 |
0.461 |
|
| 2004 |
Wu Q, Burghardt R, Safe S. Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins. The Journal of Biological Chemistry. 279: 53602-12. PMID 15471764 DOI: 10.1074/Jbc.M409778200 |
0.509 |
|
| 2004 |
Safe S. Endocrine disruptors and human health: is there a problem. Toxicology. 205: 3-10. PMID 15458784 DOI: 10.1016/J.Tox.2004.06.032 |
0.348 |
|
| 2004 |
Chen CC, Lee WR, Safe S. Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1. Journal of Cellular Biochemistry. 93: 1063-74. PMID 15449318 DOI: 10.1002/Jcb.20257 |
0.843 |
|
| 2004 |
Abdelrahim M, Smith R, Burghardt R, Safe S. Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells. Cancer Research. 64: 6740-9. PMID 15374992 DOI: 10.1158/0008-5472.Can-04-0713 |
0.468 |
|
| 2004 |
Hong J, Samudio I, Liu S, Abdelrahim M, Safe S. Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins. Endocrinology. 145: 5774-85. PMID 15345676 DOI: 10.1210/En.2004-0686 |
0.709 |
|
| 2004 |
Chintharlapalli S, Smith R, Samudio I, Zhang W, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce peroxisome proliferator-activated receptor gamma-mediated growth inhibition, transactivation, and differentiation markers in colon cancer cells. Cancer Research. 64: 5994-6001. PMID 15342379 DOI: 10.1158/0008-5472.Can-04-0399 |
0.795 |
|
| 2004 |
Li X, Qin C, Burghardt R, Safe S. Hormonal regulation of lactate dehydrogenase-A through activation of protein kinase C pathways in MCF-7 breast cancer cells. Biochemical and Biophysical Research Communications. 320: 625-34. PMID 15240094 DOI: 10.1016/J.Bbrc.2004.05.205 |
0.768 |
|
| 2004 |
Qin C, Samudio I, Ngwenya S, Safe S. Estrogen-dependent regulation of ornithine decarboxylase in breast cancer cells through activation of nongenomic cAMP-dependent pathways. Molecular Carcinogenesis. 40: 160-70. PMID 15224348 DOI: 10.1002/Mc.20030 |
0.835 |
|
| 2004 |
Safe S, Kim K. Nuclear receptor-mediated transactivation through interaction with Sp proteins. Progress in Nucleic Acid Research and Molecular Biology. 77: 1-36. PMID 15196889 DOI: 10.1016/S0079-6603(04)77001-4 |
0.718 |
|
| 2004 |
Pearce ST, Liu H, Radhakrishnan I, Abdelrahim M, Safe S, Jordan VC. Interaction of the aryl hydrocarbon receptor ligand 6-methyl-1,3,8-trichlorodibenzofuran with estrogen receptor alpha. Cancer Research. 64: 2889-97. PMID 15087408 DOI: 10.1158/0008-5472.Can-03-1770 |
0.478 |
|
| 2004 |
Qin C, Morrow D, Stewart J, Spencer K, Porter W, Smith R, Phillips T, Abdelrahim M, Samudio I, Safe S. A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. Molecular Cancer Therapeutics. 3: 247-60. PMID 15026545 |
0.837 |
|
| 2004 |
Morrow D, Qin C, Smith R, Safe S. Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation. The Journal of Steroid Biochemistry and Molecular Biology. 88: 27-36. PMID 15026081 DOI: 10.1016/J.Jsbmb.2003.10.005 |
0.782 |
|
| 2004 |
Safe S, Wormke M, Samudio I. Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells. Journal of Mammary Gland Biology and Neoplasia. 5: 295-306. PMID 14973392 DOI: 10.1023/A:1009550912337 |
0.856 |
|
| 2004 |
Corbin CJ, Mapes SM, Marcos J, Shackleton CH, Morrow D, Safe S, Wise T, Ford JJ, Conley AJ. Paralogues of porcine aromatase cytochrome P450: a novel hydroxylase activity is associated with the survival of a duplicated gene. Endocrinology. 145: 2157-64. PMID 14962994 DOI: 10.1210/En.2003-1595 |
0.329 |
|
| 2004 |
Stoner M, Wormke M, Saville B, Samudio I, Qin C, Abdelrahim M, Safe S. Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins. Oncogene. 23: 1052-63. PMID 14647449 DOI: 10.1038/Sj.Onc.1207201 |
0.844 |
|
| 2004 |
Safe S, Wormke M. Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action. Chemical Research in Toxicology. 16: 807-16. PMID 12870882 DOI: 10.1021/Tx034036R |
0.779 |
|
| 2004 |
Contractor R, Samudio IJ, Estrov Z, Harris D, McCubrey JA, Safe SH, Andreeff M, Konopleva M. A Novel Ring-Substituted Diindolylmethane 1,1-bis [3′-(5-methoxyindolyl)]-1-(p-t-butylphenyl) Methane Abrogates ERK Activation and Induces Apoptosis in Acute Myeloid Leukemia (AML). Blood. 104: 3399-3399. DOI: 10.1182/Blood.V104.11.3399.3399 |
0.637 |
|
| 2003 |
Zhang S, Qin C, Safe SH. Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. Environmental Health Perspectives. 111: 1877-82. PMID 14644660 DOI: 10.1289/Ehp.6322 |
0.759 |
|
| 2003 |
Safe S. Cadmium's disguise dupes the estrogen receptor. Nature Medicine. 9: 1000-1. PMID 12894163 DOI: 10.1038/Nm0803-1000 |
0.358 |
|
| 2003 |
Abdelrahim M, Smith R, Safe S. Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells. Molecular Pharmacology. 63: 1373-81. PMID 12761348 DOI: 10.1124/Mol.63.6.1373 |
0.484 |
|
| 2003 |
Khan S, Abdelrahim M, Samudio I, Safe S. Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast cancer cells. Endocrinology. 144: 2325-35. PMID 12746293 DOI: 10.1210/En.2002-0149 |
0.794 |
|
| 2003 |
Ngwenya S, Safe S. Cell context-dependent differences in the induction of E2F-1 gene expression by 17 beta-estradiol in MCF-7 and ZR-75 cells. Endocrinology. 144: 1675-85. PMID 12697671 DOI: 10.1210/En.2002-0009 |
0.843 |
|
| 2003 |
Castro-Rivera E, Safe S. 17 beta-estradiol- and 4-hydroxytamoxifen-induced transactivation in breast, endometrial and liver cancer cells is dependent on ER-subtype, cell and promoter context. The Journal of Steroid Biochemistry and Molecular Biology. 84: 23-31. PMID 12648521 DOI: 10.1016/S0960-0760(03)00010-4 |
0.441 |
|
| 2003 |
Qin C, Burghardt R, Smith R, Wormke M, Stewart J, Safe S. Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. Cancer Research. 63: 958-64. PMID 12615709 |
0.828 |
|
| 2003 |
Wormke M, Stoner M, Saville B, Walker K, Abdelrahim M, Burghardt R, Safe S. The aryl hydrocarbon receptor mediates degradation of estrogen receptor α through activation of proteasomes Molecular and Cellular Biology. 23: 1843-1855. PMID 12612060 DOI: 10.1128/Mcb.23.6.1843-1855.2003 |
0.832 |
|
| 2003 |
Safe S. Environmental estrogens: roles in male reproductive tract problems and in breast cancer. Reviews On Environmental Health. 17: 253-62. PMID 12611468 DOI: 10.1515/Reveh.2002.17.4.253 |
0.331 |
|
| 2003 |
Kim K, Thu N, Saville B, Safe S. Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells. Molecular Endocrinology (Baltimore, Md.). 17: 804-17. PMID 12576490 DOI: 10.1210/Me.2002-0406 |
0.755 |
|
| 2003 |
Vyhlidal C, Li X, Safe S. Estrogen regulation of transferrin gene expression in MCF-7 human breast cancer cells. Journal of Molecular Endocrinology. 29: 305-17. PMID 12459033 DOI: 10.1677/Jme.0.0290305 |
0.765 |
|
| 2003 |
Zhang W, Jiang J, Qin C, Pérez LM, Parrish AR, Safe SH, Simanek EE. Triazine Dendrimers for Drug Delivery: Evaluation of Solubilization Properties, Activity in Cell Culture, and In Vivo Toxicity of a Candidate Vehicle Supramolecular Chemistry. 15: 607-616. DOI: 10.1080/10610270310001605197 |
0.669 |
|
| 2002 |
Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, McDonnell D. Problems for risk assessment of endocrine-active estrogenic compounds. Environmental Health Perspectives. 110: 925-9. PMID 12634121 DOI: 10.1289/Ehp.02110S6925 |
0.363 |
|
| 2002 |
Stoner M, Saville B, Wormke M, Dean D, Burghardt R, Safe S. Hypoxia induces proteasome-dependent degradation of estrogen receptor α in ZR-75 breast cancer cells Molecular Endocrinology. 16: 2231-2242. PMID 12351689 DOI: 10.1210/Me.2001-0347 |
0.835 |
|
| 2002 |
Koliopanos A, Kleeff J, Xiao Y, Safe S, Zimmermann A, Büchler MW, Friess H. Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer. Oncogene. 21: 6059-70. PMID 12203118 DOI: 10.1038/Sj.Onc.1205633 |
0.462 |
|
| 2002 |
Qin C, Nguyen T, Stewart J, Samudio I, Burghardt R, Safe S. Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex. Molecular Endocrinology (Baltimore, Md.). 16: 1793-809. PMID 12145335 DOI: 10.1210/Me.2002-0006 |
0.829 |
|
| 2002 |
Abdelrahim M, Samudio I, Smith R, Burghardt R, Safe S. Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells. The Journal of Biological Chemistry. 277: 28815-22. PMID 12052832 DOI: 10.1074/Jbc.M203828200 |
0.716 |
|
| 2002 |
Duan R, Xie W, Li X, McDougal A, Safe S. Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells. Biochemical and Biophysical Research Communications. 294: 384-94. PMID 12051724 DOI: 10.1016/S0006-291X(02)00499-0 |
0.809 |
|
| 2002 |
Safe S, McDougal A. Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review). International Journal of Oncology. 20: 1123-8. PMID 12011988 DOI: 10.3892/Ijo.20.6.1123 |
0.827 |
|
| 2002 |
Mealey KL, Barhoumi R, Burghardt RC, Safe S, Kochevar DT. Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells. Antimicrobial Agents and Chemotherapy. 46: 755-61. PMID 11850258 DOI: 10.1128/Aac.46.3.755-761.2002 |
0.374 |
|
| 2002 |
Wang F, Samudio I, Safe S. Transcriptional activation of rat creatine kinase B by 17beta-estradiol in MCF-7 cells involves an estrogen responsive element and GC-rich sites. Journal of Cellular Biochemistry. 84: 156-72. PMID 11746525 DOI: 10.1002/Jcb.1276 |
0.706 |
|
| 2002 |
Saville B, Poukka H, Wormke M, Jänne OA, Palvimo JJ, Stoner M, Samudio I, Safe S. Cooperative coactivation of estrogen receptor α in ZR-75 human breast cancer cells by SNURF and TATA-binding protein Journal of Biological Chemistry. 277: 2485-2497. PMID 11696545 DOI: 10.1074/Jbc.M109021200 |
0.822 |
|
| 2001 |
Samudio I, Vyhlidal C, Wang F, Stoner M, Chen I, Kladde M, Barhoumi R, Burghardt R, Safe S. Transcriptional Activation of Deoxyribonucleic Acid Polymerase α Gene Expression in MCF-7 Cells by 17β-Estradiol. Endocrinology. 142: 1000-1008. PMID 28201425 DOI: 10.1210/Endo.142.3.8022 |
0.818 |
|
| 2001 |
Stewart DM, Johnson GA, Vyhlidal CA, Burghardt RC, Safe SH, Yu-Lee LY, Bazer FW, Spencer TE. Interferon-τ Activates Multiple Signal Transducer and Activator of Transcription Proteins and Has Complex Effects on Interferon-Responsive Gene Transcription in Ovine Endometrial Epithelial Cells* * This work was supported by NIH Grant HD-32534 (to F.W.B. and T.E.S.) and in part by NIH Grant P30-ES-09106. The publication costs of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. Endocrinology. 142: 98-107. PMID 28201367 DOI: 10.1210/endo.142.1.7891 |
0.679 |
|
| 2001 |
Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, Saville B, McDonnellc D. Toxicology of environmental estrogens. Reproduction, Fertility, and Development. 13: 307-15. PMID 11800169 DOI: 10.1071/Rd00108 |
0.379 |
|
| 2001 |
Lee JE, Safe S. Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells Biochemical Pharmacology. 62: 1113-1124. PMID 11597580 DOI: 10.1016/S0006-2952(01)00763-8 |
0.527 |
|
| 2001 |
Yoon K, Pallaroni L, Stoner M, Gaido K, Safe S. Differential activation of wild-type and variant forms of estrogen receptor α by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements Journal of Steroid Biochemistry and Molecular Biology. 78: 25-32. PMID 11530281 DOI: 10.1016/S0960-0760(01)00070-X |
0.786 |
|
| 2001 |
Waters KM, Safe S, Gaido KW. Differential gene expression in response to methoxychlor and estradiol through ERα, ERβ, and AR in reproductive tissues of female mice Toxicological Sciences. 63: 47-56. PMID 11509743 DOI: 10.1093/Toxsci/63.1.47 |
0.399 |
|
| 2001 |
McDougal A, Gupta MS, Morrow D, Ramamoorthy K, Lee JE, Safe SH. Methyl-substituted diindolylmethanes as inhibitors of estrogen-induced growth of T47D cells and mammary tumors in rats. Breast Cancer Research and Treatment. 66: 147-57. PMID 11437101 DOI: 10.1023/A:1010608000074 |
0.798 |
|
| 2001 |
Castro-Rivera E, Samudio I, Safe S. Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements. The Journal of Biological Chemistry. 276: 30853-61. PMID 11410592 DOI: 10.1074/Jbc.M103339200 |
0.711 |
|
| 2001 |
McDougal A, Wormke M, Calvin J, Safe S. Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective aryl hydrocarbon receptor modulator. Cancer Research. 61: 3902-7. PMID 11358803 |
0.349 |
|
| 2001 |
Xie W, Duan R, Safe S. Activation of adenosine deaminase in MCF-7 cells through IGF-estrogen receptor alpha crosstalk. Journal of Molecular Endocrinology. 26: 217-28. PMID 11357058 DOI: 10.1677/Jme.0.0260217 |
0.626 |
|
| 2001 |
Safe S. Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions. Vitamins and Hormones. 62: 231-52. PMID 11345900 DOI: 10.1016/S0083-6729(01)62006-5 |
0.443 |
|
| 2001 |
Safe S. Molecular biology of the Ah receptor and its role in carcinogenesis. Toxicology Letters. 120: 1-7. PMID 11323156 DOI: 10.1016/S0378-4274(01)00301-0 |
0.447 |
|
| 2001 |
Qin C, Wilson C, Blancher C, Taylor M, Safe S, Harris AL. Association of ARNT splice variants with estrogen receptor-negative breast cancer, poor induction of vascular endothelial growth factor under hypoxia, and poor prognosis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 7: 818-23. PMID 11309328 |
0.752 |
|
| 2001 |
Sanderson JT, Slobbe L, Lansbergen GW, Safe S, van den Berg M. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 61: 40-8. PMID 11294972 DOI: 10.1093/Toxsci/61.1.40 |
0.439 |
|
| 2001 |
Chen I, Hsieh T, Thomas T, Safe S. Identification of estrogen-induced genes downregulated by AhR agonists in MCF-7 breast cancer cells using suppression subtractive hybridization. Gene. 262: 207-14. PMID 11179685 DOI: 10.1016/S0378-1119(00)00530-8 |
0.501 |
|
| 2001 |
Porter W, Wang F, Duan R, Qin C, Castro-Rivera E, Kim K, Safe S. Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists. Journal of Molecular Endocrinology. 26: 31-42. PMID 11174852 DOI: 10.1677/Jme.0.0260031 |
0.837 |
|
| 2001 |
Wang F, Samudio I, Safe S. Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Molecular and Cellular Endocrinology. 172: 91-103. PMID 11165043 DOI: 10.1016/S0303-7207(00)00379-8 |
0.704 |
|
| 2001 |
Duan R, Xie W, Burghardt RC, Safe S. Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1. The Journal of Biological Chemistry. 276: 11590-8. PMID 11145955 DOI: 10.1074/Jbc.M005492200 |
0.627 |
|
| 2001 |
Stewart MD, Stewart DM, Johnson GA, Vyhlidal CA, Burghardt RC, Safe SH, Yu-Lee LY, Bazer FW, Spencer TE. Interferon-tau activates multiple signal transducer and activator of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells. Endocrinology. 142: 98-107. PMID 11145571 DOI: 10.1210/Endo.142.1.7891 |
0.708 |
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| 2000 |
Xie W, Duan R, Chen I, Samudio I, Safe S. Transcriptional Activation of Thymidylate Synthase by 17β-Estradiol in MCF-7 Human Breast Cancer Cells. Endocrinology. 141: 2439-2449. PMID 28201107 DOI: 10.1210/endo.141.7.7538 |
0.486 |
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| 2000 |
Xie W, Barwick JL, Simon CM, Pierce AM, Safe S, Blumberg B, Guzelian PS, Evans RM. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes & Development. 14: 3014-23. PMID 11114890 DOI: 10.1101/Gad.846800 |
0.538 |
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| 2000 |
Lee JE, Safe S. 3′, 4′-Dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells Toxicological Sciences. 58: 235-242. PMID 11099636 DOI: 10.1093/Toxsci/58.2.235 |
0.499 |
|
| 2000 |
Gaido KW, Maness SC, McDonnell DP, Dehal SS, Kupfer D, Safe S. Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. Molecular Pharmacology. 58: 852-8. PMID 10999957 |
0.306 |
|
| 2000 |
Wormke M, Stoner M, Saville B, Safe S. Crosstalk between estrogen receptor alpha and the aryl hydrocarbon receptor in breast cancer cells involves unidirectional activation of proteasomes. Febs Letters. 478: 109-12. PMID 10922479 DOI: 10.1016/S0014-5793(00)01830-5 |
0.847 |
|
| 2000 |
Xie W, Duan R, Chen I, Samudio I, Safe S. Transcriptional activation of thymidylate synthase by 17beta-estradiol in MCF-7 human breast cancer cells. Endocrinology. 141: 2439-49. PMID 10875244 DOI: 10.1210/Endo.141.7.7538 |
0.767 |
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| 2000 |
Yoon K, Pellaroni L, Ramamoorthy K, Gaido K, Safe S. Ligand structure-dependent differences in activation of estrogen receptor alpha in human HepG2 liver and U2 osteogenic cancer cell lines. Molecular and Cellular Endocrinology. 162: 211-20. PMID 10854714 DOI: 10.1016/S0303-7207(99)00261-0 |
0.447 |
|
| 2000 |
Vyhlidal C, Samudio I, Kladde MP, Safe S. Transcriptional activation of transforming growth factor alpha by estradiol: requirement for both a GC-rich site and an estrogen response element half-site. Journal of Molecular Endocrinology. 24: 329-38. PMID 10828826 DOI: 10.1677/Jme.0.0240329 |
0.81 |
|
| 2000 |
Wormke M, Castro-Rivera E, Chen I, Safe S. Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 72: 197-207. PMID 10822009 DOI: 10.1016/S0960-0760(00)00030-3 |
0.843 |
|
| 2000 |
Stoner M, Wang F, Wormke M, Nguyen T, Samudio I, Vyhlidal C, Marme D, Finkenzeller G, Safe S. Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins. The Journal of Biological Chemistry. 275: 22769-79. PMID 10816575 DOI: 10.1074/Jbc.M002188200 |
0.836 |
|
| 2000 |
Wang F, Duan R, Chirgwin J, Safe SH. Transcriptional activation of cathepsin D gene expression by growth factors. Journal of Molecular Endocrinology. 24: 193-202. PMID 10750020 DOI: 10.1677/Jme.0.0240193 |
0.469 |
|
| 2000 |
McDougal A, Sethi Gupta M, Ramamoorthy K, Sun G, Safe SH. Inhibition of carcinogen-induced rat mammary tumor growth and other estrogen-dependent responses by symmetrical dihalo-substituted analogs of diindolylmethane. Cancer Letters. 151: 169-79. PMID 10738111 DOI: 10.1016/S0304-3835(99)00406-1 |
0.827 |
|
| 2000 |
Saville B, Wormke M, Wang F, Nguyen T, Enmark E, Kuiper G, Gustafsson J, Safe S. Ligand-, Cell-, and Estrogen Receptor Subtype (α/β)-dependent Activation at GC-rich (Sp1) Promoter Elements Journal of Biological Chemistry. 275: 5379-5387. PMID 10681512 DOI: 10.1074/Jbc.275.8.5379 |
0.804 |
|
| 2000 |
Gaido KW, Maness SC, McDonnell DP, Dehal SS, Kupfer D, Safe S. Interaction of Methoxychlor and Related Compounds with Estrogen Receptor α and β, and Androgen Receptor: Structure-Activity Studies Molecular Pharmacology. 58: 852-858. DOI: 10.1124/Mol.58.4.852 |
0.413 |
|
| 1999 |
Qin C, Singh P, Safe S. Transcriptional Activation of Insulin-Like Growth Factor-Binding Protein-4 by 17β-Estradiol in MCF-7 Cells: Role of Estrogen Receptor-Sp1 Complexes. Endocrinology. 140: 2501-2508. PMID 28200910 DOI: 10.1210/endo.140.6.6751 |
0.73 |
|
| 1999 |
Xie W, Duan R, Safe S. Estrogen Induces Adenosine Deaminase Gene Expression in MCF-7 Human Breast Cancer Cells: Role of Estrogen Receptor-Sp1 Interactions* *This work was supported by the National Institutes of Health (Grant CA-76636), the Welch Foundation, and the Texas Agricultural Experiment Station. Endocrinology. 140: 219-227. PMID 28200731 DOI: 10.1210/endo.140.1.6394 |
0.502 |
|
| 1999 |
Safe S, Qin C, McDougal A. Development of selective aryl hydrocarbon receptor modulators for treatment of breast cancer. Expert Opinion On Investigational Drugs. 8: 1385-96. PMID 15992156 DOI: 10.1517/13543784.8.9.1385 |
0.847 |
|
| 1999 |
Gaido KW, Leonard LS, Maness SC, Hall JM, McDonnell DP, Saville B, Safe S. Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta. Endocrinology. 140: 5746-53. PMID 10579340 DOI: 10.1210/Endo.140.12.7191 |
0.44 |
|
| 1999 |
Safe S, Wargovich MJ, Lamartiniere CA, Mukhtar H. Symposium on mechanisms of action of naturally occurring anticarcinogens Toxicological Sciences. 52: 1-8. PMID 10568692 DOI: 10.1093/Toxsci/52.1.1 |
0.342 |
|
| 1999 |
Dong L, Wang W, Wang F, Stoner M, Reed JC, Harigai M, Samudio I, Kladde MP, Vyhlidal C, Safe S. Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells. The Journal of Biological Chemistry. 274: 32099-107. PMID 10542244 DOI: 10.1074/Jbc.274.45.32099 |
0.848 |
|
| 1999 |
Letcher RJ, Van Holsteijn I, Drenth HJ, Norstrom RJ, Bergman A, Safe S, Pieters R, Van Den Berg M. Cytotoxicity and aromatase (CYP19) activity modulation by organochlorines in human placental JEG-3 and JAR choriocarcinoma cells Toxicology and Applied Pharmacology. 160: 10-20. PMID 10502498 DOI: 10.1006/Taap.1999.8746 |
0.419 |
|
| 1999 |
Duan R, Porter W, Samudio I, Vyhlidal C, Kladde M, Safe S. Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Molecular Endocrinology (Baltimore, Md.). 13: 1511-21. PMID 10478842 DOI: 10.1210/Mend.13.9.0338 |
0.827 |
|
| 1999 |
Wang F, Wang W, Safe S. Regulation of constitutive gene expression through interactions of Sp1 protein with the nuclear aryl hydrocarbon receptor complex. Biochemistry. 38: 11490-500. PMID 10471301 DOI: 10.1021/Bi982578F |
0.433 |
|
| 1999 |
Fernandez P, Wilson C, Hoivik D, Safe SH. Altered phenotypic characteristics of T47d human breast cancer cells after prolonged growth in estrogen-deficient medium. Cell Biology International. 22: 623-33. PMID 10452832 DOI: 10.1006/cbir.1998.0303 |
0.327 |
|
| 1999 |
Wang W, Dong L, Saville B, Safe S. Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions. Molecular Endocrinology (Baltimore, Md.). 13: 1373-87. PMID 10446910 DOI: 10.1210/Mend.13.8.0323 |
0.465 |
|
| 1999 |
Castro-Rivera E, Wormke M, Safe S. Estrogen and aryl hydrocarbon responsiveness of ECC-1 endometrial cancer cells. Molecular and Cellular Endocrinology. 150: 11-21. PMID 10411295 DOI: 10.1016/S0303-7207(99)00041-6 |
0.839 |
|
| 1999 |
Nguyen TA, Hoivik D, Lee JE, Safe S. Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. Archives of Biochemistry and Biophysics. 367: 250-7. PMID 10395741 DOI: 10.1006/Abbi.1999.1282 |
0.48 |
|
| 1999 |
Qin C, Singh P, Safe S. Transcriptional activation of insulin-like growth factor-binding protein-4 by 17beta-estradiol in MCF-7 cells: role of estrogen receptor-Sp1 complexes. Endocrinology. 140: 2501-8. PMID 10342835 DOI: 10.1210/Endo.140.6.6751 |
0.778 |
|
| 1999 |
Safe S, Connor K, Gaido K. Methods for xenoestrogen testing. Toxicology Letters. 665-70. PMID 10022332 DOI: 10.1016/S0378-4274(98)00283-5 |
0.407 |
|
| 1999 |
Ramamoorthy K, Gupta MS, Sun G, McDougal A, Safe SH. 3,3'4,4'-Tetrachlorobiphenyl exhibits antiestrogenic and antitumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells. Carcinogenesis. 20: 115-23. PMID 9934858 DOI: 10.1093/Carcin/20.1.115 |
0.852 |
|
| 1999 |
Xie W, Duan R, Safe S. Estrogen induces adenosine deaminase gene expression in MCF-7 human breast cancer cells: role of estrogen receptor-Sp1 interactions. Endocrinology. 140: 219-27. PMID 9886828 DOI: 10.1210/Endo.140.1.6394 |
0.62 |
|
| 1998 |
Gupta M, McDougal A, Safe S. Estrogenic and antiestrogenic activities of 16alpha- and 2-hydroxy metabolites of 17beta-estradiol in MCF-7 and T47D human breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 67: 413-9. PMID 10030690 DOI: 10.1016/S0960-0760(98)00135-6 |
0.799 |
|
| 1998 |
Safe S, Wang F, Porter W, Duan R, McDougal A. Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms. Toxicology Letters. 102: 343-7. PMID 10022276 DOI: 10.1016/S0378-4274(98)00331-2 |
0.834 |
|
| 1998 |
Gaido K, Dohme L, Wang F, Chen I, Blankvoort B, Ramamoorthy K, Safe S. Comparative estrogenic activity of wine extracts and organochlorine pesticide residues in food. Environmental Health Perspectives. 106: 1347-51. PMID 9860891 DOI: 10.1289/Ehp.98106S61347 |
0.423 |
|
| 1998 |
Wilson CL, Safe S. Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses. Toxicologic Pathology. 26: 657-71. PMID 9789953 DOI: 10.1177/019262339802600510 |
0.416 |
|
| 1998 |
Chen I, McDougal A, Wang F, Safe S. Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. Carcinogenesis. 19: 1631-9. PMID 9771935 DOI: 10.1093/Carcin/19.9.1631 |
0.836 |
|
| 1998 |
Wang W, Smith R, Safe S. Aryl hydrocarbon receptor-mediated antiestrogenicity in MCF-7 cells: modulation of hormone-induced cell cycle enzymes. Archives of Biochemistry and Biophysics. 356: 239-48. PMID 9705214 DOI: 10.1006/Abbi.1998.0782 |
0.447 |
|
| 1998 |
Sun G, Porter W, Safe S. Estrogen-induced retinoic acid receptor alpha 1 gene expression: role of estrogen receptor-Sp1 complex. Molecular Endocrinology (Baltimore, Md.). 12: 882-90. PMID 9626663 DOI: 10.1210/Mend.12.6.0125 |
0.656 |
|
| 1998 |
Castro-Rivera E, Safe S. Estrogen- and antiestrogen-responsiveness of HEC1A endometrial adenocarcinoma cells in culture. The Journal of Steroid Biochemistry and Molecular Biology. 64: 287-95. PMID 9618030 DOI: 10.1016/S0960-0760(97)00202-1 |
0.484 |
|
| 1998 |
Wang F, Hoivik D, Pollenz R, Safe S. Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes. Nucleic Acids Research. 26: 3044-52. PMID 9611253 DOI: 10.1093/Nar/26.12.3044 |
0.443 |
|
| 1998 |
Willett KL, Randerath K, Zhou GD, Safe SH. Inhibition of CYP1A1-dependent activity by the polynuclear aromatic hydrocarbon (PAH) fluoranthene Biochemical Pharmacology. 55: 831-839. PMID 9586956 DOI: 10.1016/S0006-2952(97)00561-3 |
0.302 |
|
| 1998 |
Duan R, Porter W, Safe S. Estrogen-induced c-fos protooncogene expression in MCF-7 human breast cancer cells: role of estrogen receptor Sp1 complex formation. Endocrinology. 139: 1981-90. PMID 9528985 DOI: 10.1210/Endo.139.4.5870 |
0.522 |
|
| 1998 |
Vom Saal FS, Welshons WV, Hansen LG, Talbott EO, Zborowski JV, Kuller LH, Gammon MD, Terry MB, Teitelbaum SL, Britton JA, Levin B, Bigsby RM, Steinmetz R, Verma SP, Goldin BR, ... ... Safe S, et al. Organochlorine residues and breast cancer [1] (multiple letters) New England Journal of Medicine. 338: 988-991. PMID 9527606 DOI: 10.1056/Nejm199804023381411 |
0.338 |
|
| 1998 |
Safe S. Limitations of the toxic equivalency factor approach for risk assessment of TCDD and related compounds. Teratogenesis, Carcinogenesis, and Mutagenesis. 17: 285-304. PMID 9508738 DOI: 10.1002/(Sici)1520-6866(1997)17:4/5<285::Aid-Tcm11>3.0.Co;2-B |
0.309 |
|
| 1998 |
McDougal A, Safe S. Induction of 16alpha-/2-hydroxyestrone metabolite ratios in MCF-7 cells by pesticides, carcinogens, and antiestrogens does not predict mammary carcinogens. Environmental Health Perspectives. 106: 203-6. PMID 9494123 DOI: 10.1289/Ehp.98106203 |
0.763 |
|
| 1998 |
Porter W, Saville B, Hoivik D, Safe S. Functional synergy between the transcription factor Sp1 and the estrogen receptor. Molecular Endocrinology (Baltimore, Md.). 11: 1569-80. PMID 9328340 DOI: 10.1210/Mend.11.11.9916 |
0.42 |
|
| 1997 |
McDougal A, Wilson C, Safe S. Induction of estradiol 2-hydroxylase activity in MCF-7 human breast cancer cells by pesticides and carcinogens. Environmental Toxicology and Pharmacology. 3: 195-9. PMID 21781778 DOI: 10.1016/S1382-6689(97)00013-6 |
0.801 |
|
| 1997 |
McDougal A, Wilson C, Safe S. Inhibition of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumor growth by aryl hydrocarbon receptor agonists. Cancer Letters. 120: 53-63. PMID 9570386 DOI: 10.1016/S0304-3835(97)00299-1 |
0.785 |
|
| 1997 |
Hoivik D, Wilson C, Wang W, Willett K, Barhoumi R, Burghardt R, Safe S. Studies on the relationship between estrogen receptor content, glutathione S-transferase pi expression, and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells. Archives of Biochemistry and Biophysics. 348: 174-82. PMID 9390189 DOI: 10.1006/Abbi.1997.0380 |
0.49 |
|
| 1997 |
Hoivik D, Willett K, Wilson C, Safe S. Estrogen does not inhibit 2,3,7,8-tetrachlorodibenzo-p-dioxinmediated effects in MCF-7 and Hepa 1c1c7 cells Journal of Biological Chemistry. 272: 30270-30274. PMID 9374512 DOI: 10.1074/Jbc.272.48.30270 |
0.496 |
|
| 1997 |
Fielden MR, Chen I, Chittim B, Safe SH, Zacharewski TR. Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155). Environmental Health Perspectives. 105: 1238-48. PMID 9370515 |
0.792 |
|
| 1997 |
Wang W, Smith R, Burghardt R, Safe SH. 17 beta-Estradiol-mediated growth inhibition of MDA-MB-468 cells stably transfected with the estrogen receptor: cell cycle effects. Molecular and Cellular Endocrinology. 133: 49-62. PMID 9359472 DOI: 10.1016/S0303-7207(97)00142-1 |
0.337 |
|
| 1997 |
Ramamoorthy K, Vyhlidal C, Wang F, Chen I, Safe S, McDonnell DP, Leonard LS, Gaido KW. Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. Toxicology and Applied Pharmacology. 147: 93-100. PMID 9356311 DOI: 10.1006/Taap.1997.8281 |
0.754 |
|
| 1997 |
Safe S, Connor K, Ramamoorthy K, Gaido K, Maness S. Human exposure to endocrine-active chemicals: hazard assessment problems. Regulatory Toxicology and Pharmacology : Rtp. 26: 52-8. PMID 9339480 DOI: 10.1006/Rtph.1997.1118 |
0.358 |
|
| 1997 |
Wilson CL, Thomsen J, Hoivik DJ, Wormke MT, Stanker L, Holtzapple C, Safe SH. Aryl hydrocarbon (Ah) nonresponsiveness in estrogen receptor-negative MDA-MB-231 cells is associated with expression of a variant arnt protein. Archives of Biochemistry and Biophysics. 346: 65-73. PMID 9328285 DOI: 10.1006/Abbi.1997.0289 |
0.819 |
|
| 1997 |
Earl Gray L, Kelce WR, Wiese T, Tyl R, Gaido K, Cook J, Klinefelter G, Desaulniers D, Wilson E, Zacharewski T, Waller C, Foster P, Laskey J, Reel J, Giesy J, ... ... Safe S, et al. Endocrine Screening Methods Workshop report: Detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms Reproductive Toxicology. 11: 719-750. PMID 9311581 DOI: 10.1016/S0890-6238(97)00025-7 |
0.311 |
|
| 1997 |
Connor K, Ramamoorthy K, Moore M, Mustain M, Chen I, Safe S, Zacharewski T, Gillesby B, Joyeux A, Balaguer P. Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: structure-activity relationships. Toxicology and Applied Pharmacology. 145: 111-23. PMID 9221830 DOI: 10.1006/Taap.1997.8169 |
0.477 |
|
| 1997 |
Sun G, Safe S. Antiestrogenic activities of alternate-substituted polychlorinated dibenzofurans in MCF-7 human breast cancer cells. Cancer Chemotherapy and Pharmacology. 40: 239-44. PMID 9219508 DOI: 10.1007/S002800050653 |
0.628 |
|
| 1997 |
Wang F, Porter W, Xing W, Archer TK, Safe S. Identification of a functional imperfect estrogen-responsive element in the 5'-promoter region of the human cathepsin D gene. Biochemistry. 36: 7793-801. PMID 9201922 DOI: 10.1021/bi963100j |
0.313 |
|
| 1997 |
Safe SH. Is there an association between exposure to environmental estrogens and breast cancer? Environmental Health Perspectives. 675-8. PMID 9168013 DOI: 10.1289/ehp.97105s3675 |
0.316 |
|
| 1997 |
Gillesby BE, Stanostefano M, Porter W, Safe S, Wu ZF, Zacharewski TR. Identification of a motif within the 5' regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression Biochemistry. 36: 6080-6089. PMID 9166778 DOI: 10.1021/Bi962131B |
0.68 |
|
| 1997 |
Wang WL, Porter W, Burghardt R, Safe SH. Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Carcinogenesis. 18: 925-33. PMID 9163677 DOI: 10.1093/Carcin/18.5.925 |
0.405 |
|
| 1997 |
Safe SH, Zacharewski T. Organochlorine exposure and risk for breast cancer. Progress in Clinical and Biological Research. 396: 133-45. PMID 9108595 |
0.318 |
|
| 1997 |
Ramamoorthy K, Wang F, Chen IC, Norris JD, McDonnell DP, Leonard LS, Gaido KW, Bocchinfuso WP, Korach KS, Safe S. Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. Endocrinology. 138: 1520-7. PMID 9075711 DOI: 10.1210/Endo.138.4.5056 |
0.467 |
|
| 1997 |
Nodland KI, Wormke M, Safe S. Inhibition of estrogen-induced activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-7 human breast cancer and other cell lines transfected with vitellogenin A2 gene promoter constructs. Archives of Biochemistry and Biophysics. 338: 67-72. PMID 9015389 DOI: 10.1006/Abbi.1996.9806 |
0.843 |
|
| 1997 |
Moore M, Mustain M, Daniel K, Chen I, Safe S, Zacharewski T, Gillesby B, Joyeux A, Balaguer P. Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum. Toxicology and Applied Pharmacology. 142: 160-8. PMID 9007045 DOI: 10.1006/Taap.1996.8022 |
0.497 |
|
| 1997 |
Ramamoorthy K, Wang F, Chen IC, Safe S, Norris JD, McDonnell DP, Gaido KW, Korach KS, McLachlan JA, Arnold SF, Klotz DM, Collins BM, Vonier PM, Guillette LJ. Potency of combined estrogenic pesticides Science. 275: 405-406. PMID 9005556 DOI: 10.1126/Science.275.5298.405 |
0.309 |
|
| 1997 |
Porter W, Wang F, Wang W, Duan R, Safe S. Role of estrogen receptor/Sp1 complexes in estrogen-induced heat shock protein 27 gene expression. Molecular Endocrinology (Baltimore, Md.). 10: 1371-8. PMID 8923463 DOI: 10.1210/Mend.10.11.8923463 |
0.458 |
|
| 1997 |
Fielden MR, Chen I, Chittim B, Safe SH, Zacharewski TR. Examination of the Estrogenicity of 2,4,6,2 prime ,6 prime -Pentachlorobiphenyl (PCB 104), Its Hydroxylated Metabolite 2,4,6,2 prime ,6 prime -Pentachloro-4-Biphenylol (HO-PCB 104), and a Further Chlorinated Derivative, 2,4,6,2 prime ,4 prime ,6 prime -Hexachlorobiphenyl (PCB 155) Environmental Health Perspectives. 105: 1238. DOI: 10.2307/3433904 |
0.709 |
|
| 1997 |
Safe SH, McDougal A. Environmental factors and breast cancer Endocrine Related Cancer. 4: 113-123. DOI: 10.1677/Erc.0.0040113 |
0.758 |
|
| 1996 |
Lu YF, Santostefano M, Cunningham BD, Threadgill MD, Safe S. Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists. Biochemical Pharmacology. 51: 1077-87. PMID 8866830 DOI: 10.1016/0006-2952(96)00063-9 |
0.427 |
|
| 1996 |
Chen I, Safe S, Bjeldanes L. Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells. Biochemical Pharmacology. 51: 1069-76. PMID 8866829 DOI: 10.1016/0006-2952(96)00060-3 |
0.414 |
|
| 1996 |
Connor K, Howell J, Chen I, Liu H, Berhane K, Sciarretta C, Safe S, Zacharewski T. Failure of chloro-S-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro Fundamental and Applied Toxicology. 30: 93-101. PMID 8812239 DOI: 10.1093/Toxsci/30.1.93 |
0.486 |
|
| 1996 |
Lu YF, Sun G, Wang X, Safe S. Inhibition of prolactin receptor gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 human breast cancer cells. Archives of Biochemistry and Biophysics. 332: 35-40. PMID 8806706 DOI: 10.1006/Abbi.1996.0313 |
0.644 |
|
| 1996 |
Hanneman WH, Legare ME, Barhoumi R, Burghardt RC, Safe S, Tiffany-Castiglioni E. Stimulation of calcium uptake in cultured rat hippocampal neurons by 2,3,7,8-tetrachlorodibenzo-p-dioxin Toxicology. 112: 19-28. PMID 8792845 DOI: 10.1016/0300-483X(96)03346-X |
0.302 |
|
| 1996 |
Liu H, Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on insulin-induced responses in MCF-7 human breast cancer cells. Toxicology and Applied Pharmacology. 138: 242-50. PMID 8658525 DOI: 10.1006/Taap.1996.0122 |
0.381 |
|
| 1996 |
Santostefano M, Safe S. Characterization of the molecular and structural properties of the transformed and nuclear aryl hydrocarbon (Ah) receptor complexes by proteolytic digestion. Chemico-Biological Interactions. 100: 221-40. PMID 8653805 DOI: 10.1016/0009-2797(96)03701-5 |
0.353 |
|
| 1996 |
Harper N, Steinberg M, Safe S. Immunotoxicity of a reconstituted polynuclear aromatic hydrocarbon mixture in B6C3F1 mice. Toxicology. 109: 31-8. PMID 8619250 DOI: 10.1016/0300-483X(95)03302-V |
0.309 |
|
| 1996 |
Moore M, Ruh M, Steinberg M, Safe S. Isolation and characterization of variant benzo[a]pyrene-resistant T47D human breast-cancer cells. International Journal of Cancer. 66: 117-23. PMID 8608954 DOI: 10.1002/(Sici)1097-0215(19960328)66:1<117::Aid-Ijc20>3.0.Co;2-9 |
0.476 |
|
| 1996 |
Wang WL, Thomsen JS, Porter W, Moore M, Safe S. Effect of transient expression of the oestrogen receptor on constitutive and inducible CYP1A1 in Hs578T human breast cancer cells. British Journal of Cancer. 73: 316-22. PMID 8562336 DOI: 10.1038/Bjc.1996.55 |
0.503 |
|
| 1996 |
Dickerson R, Keller LH, Safe S. Alkyl polychlorinated dibenzofurans and related compounds as antiestrogens in the female rat uterus: structure-activity studies. Toxicology and Applied Pharmacology. 135: 287-98. PMID 8545839 DOI: 10.1006/Taap.1995.1235 |
0.316 |
|
| 1996 |
Safe SH. Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Pharmacology & Therapeutics. 67: 247-81. PMID 7494865 DOI: 10.1016/0163-7258(95)00017-B |
0.374 |
|
| 1995 |
Xiaohong Wang, Thomsen JS, Santostefano M, Rosengren R, Safe S, Perdew GH. Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines European Journal of Pharmacology: Environmental Toxicology And. 293: 191-205. PMID 8666036 DOI: 10.1016/0926-6917(95)00017-8 |
0.439 |
|
| 1995 |
Connor K, Safe S, Jefcoate CR, Larsen M. Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats Biochemical Pharmacology. 50: 1913-1920. PMID 8615872 DOI: 10.1016/0006-2952(95)02087-X |
0.335 |
|
| 1995 |
Safe S, Krishnan V. Chlorinated hydrocarbons: estrogens and antiestrogens Toxicology Letters. 82: 731-736. PMID 8597135 DOI: 10.1016/0378-4274(95)03591-5 |
0.494 |
|
| 1995 |
Krishnan V, Porter W, Santostefano M, Wang X, Safe S. Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells Molecular and Cellular Biology. 15: 6710-6719. PMID 8524236 DOI: 10.1128/Mcb.15.12.6710 |
0.491 |
|
| 1995 |
Wang X, Safe S. Development of an in vitro model for investigating the formation of the nuclear Ah receptor complex in mouse Hepa 1c1c7 cells. Archives of Biochemistry and Biophysics. 315: 285-92. PMID 7986070 DOI: 10.1006/Abbi.1994.1502 |
0.392 |
|
| 1995 |
Santosfefano M, Liu H, Wang X, Chaloupka K, Safe S. Effect of ligand structure on formation and DNA binding properties of the transformed rat cytosolic aryl hydrocarbon receptor. Chemical Research in Toxicology. 7: 544-50. PMID 7981419 DOI: 10.1021/Tx00040A010 |
0.358 |
|
| 1995 |
Lu YF, Santostefano M, Cunningham BD, Threadgill MD, Safe S. Identification of 3'-methoxy-4'-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells. Archives of Biochemistry and Biophysics. 316: 470-7. PMID 7840652 DOI: 10.1006/Abbi.1995.1062 |
0.483 |
|
| 1995 |
Harper N, Wang X, Liu H, Safe S. Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists. Molecular and Cellular Endocrinology. 104: 47-55. PMID 7821706 DOI: 10.1016/0303-7207(94)90050-7 |
0.482 |
|
| 1995 |
Safe S, Krishnan V. Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression Archives of Toxicology. Supplement. Archiv Fur Toxikologie. Supplement. 17: 99-115. PMID 7786196 DOI: 10.1007/978-3-642-79451-3_8 |
0.514 |
|
| 1995 |
Chaloupka K, Steinberg M, Santostefano M, Rodriguez LV, Goldstein L, Safe S. Induction of Cyp1a-1 and Cyp1a-2 gene expression by a reconstituted mixture of polynuclear aromatic hydrocarbons in B6C3F1 mice. Chemico-Biological Interactions. 96: 207-21. PMID 7750161 DOI: 10.1016/0009-2797(94)03586-W |
0.318 |
|
| 1995 |
Merchant M, Safe S. In vitro inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced activity by α-naphthoflavone and 6-methyl-1,3,8-trichlorodibenzofuran using an aryl hydrocarbon (Ah)-responsive construct Biochemical Pharmacology. 50: 663-668. PMID 7669069 DOI: 10.1016/0006-2952(95)00180-8 |
0.434 |
|
| 1995 |
Harper N, Steinberg M, Thomsen J, Safe S. Halogenated aromatic hydrocarbon-induced suppression of the plaque-forming cell response in B6C3F1 splenocytes cultured with allogenic mouse serum: Ah receptor structure activity relationships. Toxicology. 99: 199-206. PMID 7610466 DOI: 10.1016/0300-483X(95)03064-M |
0.376 |
|
| 1995 |
Ruh MF, Zacharewski T, Connor K, Howell J, Chen I, Safe S. Naringenin: a weakly estrogenic bioflavonoid that exhibits antiestrogenic activity. Biochemical Pharmacology. 50: 1485-93. PMID 7503800 DOI: 10.1016/0006-2952(95)02061-6 |
0.419 |
|
| 1995 |
Willett K, Steinberg M, Thomsen J, Narasimhan TR, Safe S, McDonald S, Beatty K, Kennicutt MC. Exposure of killifish to benzo[a]pyrene: comparative metabolism, DNA adduct formation and aryl hydrocarbon (Ah) receptor agonist activities Comparative Biochemistry and Physiology -- Part B: Biochemistry And. 112: 93-103. DOI: 10.1016/0305-0491(95)00034-6 |
0.362 |
|
| 1995 |
HARPER N, CONNOR K, STEINBERG M, SAFE S. Immunosuppressive Activity of Polychiorinated Biphenyl Mixtures and Congeners: Nonadditive (Antagonistic) Interactions Toxicological Sciences. 27: 131-139. DOI: 10.1006/Faat.1995.1116 |
0.324 |
|
| 1994 |
Thomsen JS, Wang X, Hines RN, Safe S. Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor. Carcinogenesis. 15: 933-7. PMID 8200098 DOI: 10.1093/Carcin/15.5.933 |
0.494 |
|
| 1994 |
Fernandez P, Burghardt R, Smith R, Nodland K, Safe S. High passage T47D human breast cancer cells: altered endocrine and 2,3,7,8-tetrachlorodibenzo-p-dioxin responsiveness. European Journal of Pharmacology. 270: 53-65. PMID 8157081 DOI: 10.1016/0926-6917(94)90080-9 |
0.459 |
|
| 1994 |
Liu H, Santostefano M, Safe S. 2-Phenylphenanthridinone and related compounds: aryl hydrocarbon receptor agonists and suicide inactivators of P4501A1. Archives of Biochemistry and Biophysics. 313: 206-14. PMID 8080264 DOI: 10.1006/Abbi.1994.1378 |
0.416 |
|
| 1994 |
Lu Y, Wang X, Safe S. Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoic acid in MCF-7 human breast cancer cells. Toxicology and Applied Pharmacology. 127: 1-8. PMID 8048042 DOI: 10.1006/Taap.1994.1132 |
0.425 |
|
| 1994 |
Holcomb M, Safe S. Inhibition of 7,12-dimethylbenzanthracene-induced rat mammary tumor growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cancer Letters. 82: 43-7. PMID 8033067 DOI: 10.1016/0304-3835(94)90144-9 |
0.352 |
|
| 1994 |
Chaloupka K, Santostefano M, Goldfarb IS, Liu G, Myers MJ, Tsyrolv IB, Gelboin HV, Krishnan V, Safe S. Aryl hydrocarbon (Ah) receptor-independent induction of Cyp1a2 gene expression by acenaphthylene and related compounds in B6C3F1 mice Carcinogenesis. 15: 2835-2840. PMID 8001243 DOI: 10.1093/Carcin/15.12.2835 |
0.397 |
|
| 1994 |
Liu H, Wormke M, Safe SH, Bjeldanes LF. Indolo[3,2-b]carbazole: a dietary-derived factor that exhibits both antiestrogenic and estrogenic activity. Journal of the National Cancer Institute. 86: 1758-65. PMID 7966413 DOI: 10.1093/Jnci/86.23.1758 |
0.77 |
|
| 1994 |
Narasimhan TR, Craig A, Arellano L, Harper N, Howie L, Menache M, Birnbaum L, Safe S. Relative sensitivities of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced Cyp1a-1 and Cyp1a-2 gene expression and immunotoxicity in female B6C3F1 mice. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 23: 598-607. PMID 7867912 DOI: 10.1006/Faat.1994.1146 |
0.32 |
|
| 1994 |
Nakai JS, Winhall MJ, Bunce NJ, Rosengren R, Safe S. Comparative kinetic study of the binding between 2,3,7,8‐tetrachlorodibenzo‐ρ‐dioxin and related ligands with the hepatic Ah receptors from several rodent species Journal of Biochemical Toxicology. 9: 199-209. PMID 7853354 DOI: 10.1002/Jbt.2570090405 |
0.315 |
|
| 1994 |
Carvan MJ, SANTOSTEFANO M, SAFE S, BUSBEE D. CHARACTERIZATION OF A BOTTLENOSE DOLPHIN (TURSIOPS TRUNCATUS) KIDNEY EPITHELIAL CELL LINE Marine Mammal Science. 10: 52-69. DOI: 10.1111/J.1748-7692.1994.Tb00389.X |
0.388 |
|
| 1993 |
Randerath E, Randerath K, Reddy R, Narasimhan TR, Wang X, Safe S. Effects of polychlorinated dibenzofurans on compounds in hepatic DNA of female Sprague-Dawley rats: structure dependence and mechanistic considerations. Chemico-Biological Interactions. 88: 175-90. PMID 8403078 DOI: 10.1016/0009-2797(93)90090-L |
0.351 |
|
| 1993 |
Moore M, Narasimhan TR, Steinberg MA, Wang X, Safe S. Potentiation of CYP1A1 gene expression in MCF-7 human breast cancer cells cotreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 12-O-tetradecanoylphorbol-13-acetate. Archives of Biochemistry and Biophysics. 305: 483-8. PMID 8396892 DOI: 10.1006/Abbi.1993.1451 |
0.465 |
|
| 1993 |
Merchant M, Krishnan V, Safe S. Mechanism of action of α-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells Toxicology and Applied Pharmacology. 120: 179-185. PMID 8390116 DOI: 10.1006/Taap.1993.1101 |
0.486 |
|
| 1993 |
Moore M, Narasimhan TR, Wang X, Krishnan V, Safe S, Williams HJ, Scott AI. Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 17 beta-estradiol in MCF-7 human breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 44: 251-61. PMID 8384872 DOI: 10.1016/0960-0760(93)90085-B |
0.437 |
|
| 1993 |
Arellano LO, Wang X, Safe S. Effects of cycloheximide on the induction of CYP1A1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in three human breast cancer cell lines. Carcinogenesis. 14: 219-22. PMID 8382112 DOI: 10.1093/Carcin/14.2.219 |
0.432 |
|
| 1993 |
Safe S. Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems. Environmental Health Perspectives. 100: 259-68. PMID 8354174 DOI: 10.1289/Ehp.93100259 |
0.348 |
|
| 1993 |
Harper N, Connor K, Safe S. Immunotoxic potencies of polychlorinated biphenyl (PCB), dibenzofuran (PCDF) and dibenzo-p-dioxin (PCDD) congeners in C57BL/6 and DBA/2 mice. Toxicology. 80: 217-27. PMID 8328002 DOI: 10.1016/0300-483X(93)90183-S |
0.359 |
|
| 1993 |
Harper N, Howie L, Connor K, Arellano L, Craig A, Dickerson R, Safe S. Immunosuppressive and monooxygenase induction activities of highly chlorinated diphenyl ether congeners in C57BL/6 and DBA/2 mice. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 20: 496-502. PMID 8314464 DOI: 10.1006/Faat.1993.1060 |
0.351 |
|
| 1993 |
Harris M, Zacharewski T, Safe S. Comparative potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in male Wistar rats--assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs). Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 20: 456-63. PMID 8314461 DOI: 10.1006/Faat.1993.1056 |
0.335 |
|
| 1993 |
Harper N, Howie L, Connor K, Dickerson R, Safe S. Immunosuppressive effects of highly chlorinated biphenyls and diphenyl ethers on T-cell dependent and independent antigens in mice. Toxicology. 85: 123-35. PMID 8303708 DOI: 10.1016/0300-483X(93)90037-S |
0.361 |
|
| 1993 |
Wang X, Porter W, Krishnan V, Narasimhan TR, Safe S. Mechanism of 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells Molecular and Cellular Endocrinology. 96: 159-166. PMID 8276131 DOI: 10.1016/0303-7207(93)90106-T |
0.445 |
|
| 1993 |
Chaloupka K, Harper N, Krishnan V, Santostefano M, Rodriguez LV, Safe S. Synergistic activity of polynuclear aromatic hydrocarbon mixtures as aryl hydrocarbon (Ah) receptor agonists Chemico-Biological Interactions. 89: 141-158. PMID 8269543 DOI: 10.1016/0009-2797(93)90005-J |
0.454 |
|
| 1993 |
Liu H, Santostefano M, Lu Y, Safe S. 6-substituted 3,4-benzocoumarins: a new structural class of inducers and inhibitors of CYP1A1-dependent activity. Archives of Biochemistry and Biophysics. 306: 223-31. PMID 8215408 DOI: 10.1006/Abbi.1993.1504 |
0.439 |
|
| 1993 |
Safe S. Development of bioassays and approaches for the risk assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Environmental Health Perspectives. 101: 317-325. PMID 8143638 DOI: 10.1289/Ehp.93101S3317 |
0.302 |
|
| 1993 |
Krishnan V, Safe S. Polychlorinated biphenyls (PCB), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: Quantitative structure-activity relationships Toxicology and Applied Pharmacology. 120: 55-61. PMID 7685553 DOI: 10.1006/Taap.1993.1086 |
0.485 |
|
| 1993 |
Wang X, Santostefano M, Lu Y, Safe S. A comparison of the mouse versus human aryl hydrocarbon (Ah) receptor complex: effects of proteolysis. Chemico-Biological Interactions. 85: 79-93. PMID 1333892 DOI: 10.1016/0009-2797(92)90054-O |
0.349 |
|
| 1992 |
Krishnan V, Narasimhan T, Safe S. Development of gel staining techniques for detecting the secretion of procathepsin D (52-kDa protein) in MCF-7 human breast cancer cells Analytical Biochemistry. 204: 137-142. PMID 1381155 DOI: 10.1016/0003-2697(92)90152-W |
0.377 |
|
| 1992 |
Chaloupka K, Krishnan V, Safe S. Polynuclear aromatic hydrocarbon carcinogens as antiestrogens m MCF-7 human breast cancer cells: Role of the Ah receptor Carcinogenesis. 13: 2233-2239. PMID 1335374 DOI: 10.1093/Carcin/13.12.2233 |
0.475 |
|
| 1992 |
Liu H, Biegel L, Narasimhan TR, Rowlands C, Safe S. Inhibition of insulin-like growth factor-I responses in MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Molecular and Cellular Endocrinology. 87: 19-28. PMID 1332906 DOI: 10.1016/0303-7207(92)90229-Y |
0.424 |
|
| 1992 |
Merchant M, Morrison V, Santostefano M, Safe S. Mechanism of action of aryl hydrocarbon receptor antagonists: Inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression Archives of Biochemistry and Biophysics. 298: 389-394. PMID 1329656 DOI: 10.1016/0003-9861(92)90426-W |
0.442 |
|
| 1992 |
Rosengren R, Safe S, Bunce NJ. Kinetics of the association of several tritiated polychlorinated dibenzo-p-dioxin and dibenzofuran congeners with hepatic cytosolic Ah receptor from the Wistar rat. Chemical Research in Toxicology. 5: 376-82. PMID 1324021 DOI: 10.1021/Tx00027A009 |
0.339 |
|
| 1992 |
Fernandez P, Safe S. Growth inhibitory and antimitogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in T47D human breast cancer cells. Toxicology Letters. 61: 185-97. PMID 1322575 DOI: 10.1016/0378-4274(92)90145-A |
0.431 |
|
| 1992 |
Santostefano M, Piskorska-Pliszczynska J, Morrison V, Safe S. Effects of ligand structure on the in vitro transformation of the rat cytosolic aryl hydrocarbon receptor. Archives of Biochemistry and Biophysics. 297: 73-9. PMID 1322114 DOI: 10.1016/0003-9861(92)90642-A |
0.35 |
|
| 1992 |
Wang X, Rosengren R, Morrison V, Santostefano M, Safe S. Characterization of the aryl hydrocarbon receptor in the human C-4II cervical squamous carcinoma cell line. Biochemical Pharmacology. 43: 1635-42. PMID 1314608 DOI: 10.1016/0006-2952(92)90223-6 |
0.408 |
|
| 1992 |
Zacharewski T, Harris M, Biegel L, Morrison V, Merchant M, Safe S. 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor. Toxicology and Applied Pharmacology. 113: 311-8. PMID 1313996 DOI: 10.1016/0041-008X(92)90130-K |
0.472 |
|
| 1992 |
Dickerson R, Howie L, Safe S. The effect of 6-nitro-1,3,8-trichlorodibenzofuran as a partial estrogen in the female rat uterus. Toxicology and Applied Pharmacology. 113: 55-63. PMID 1313194 DOI: 10.1016/0041-008X(92)90008-G |
0.42 |
|
| 1992 |
Merchant M, Wang X, Kamps C, Rosengren R, Morrison V, Safe S. Mechanism of benzo[a]pyrene-induced Cyp1a-1 gene expression in mouse Hepa 1c1c7 cells: role of the nuclear 6 s and 4 s proteins. Archives of Biochemistry and Biophysics. 292: 250-7. PMID 1309295 DOI: 10.1016/0003-9861(92)90076-9 |
0.372 |
|
| 1992 |
Safe S, Biegel L, Harris M, Narasimhan TR, Lui H, Fernandez P. Inhibition of estrogen- and growth factor-induced proliferation of human breast cancer cell lines by TCDD: characterization and mechanistic studies Chemosphere. 25: 83-86. DOI: 10.1016/0045-6535(92)90485-A |
0.466 |
|
| 1992 |
Wang X, Rosengren R, Morrison V, Safe S. Characterization of the human Ah receptor Chemosphere. 25: 997-1000. DOI: 10.1016/0045-6535(92)90098-C |
0.385 |
|
| 1992 |
Rowlands C, Safe S, Langdon S, Miller WR, Lawrie S. Human ovarian cancer cells: interaction with Tetrachlorodibenzo-p-dioxin (TCDD) Chemosphere. 25: 979-983. DOI: 10.1016/0045-6535(92)90095-9 |
0.445 |
|
| 1992 |
Randerath K, Randerath E, Reddy R, Narasimhan T, Wang X, Safe S. Structure-dependent reduction in DNA I-compound adducts by polychlorinated dibenzofurans in female Sprague-Dawley rat liver Chemosphere. 25: 975-978. DOI: 10.1016/0045-6535(92)90094-8 |
0.324 |
|
| 1992 |
Merchant M, Morrison V, Safe S. Antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) - induced cyp1A1 gene expression by 6-methyl-1,3,8-trichlorodibenzofuran (MCDF): Mechanistic studies Chemosphere. 25: 967-973. DOI: 10.1016/0045-6535(92)90093-7 |
0.415 |
|
| 1992 |
Liu H, Narasimhan TR, Safe S. 2,3,7,8-Tetrachlorodibenzo-p-dioxin as an antiproliferative agent in human breast cancer cells: Effects on insulin-induced cell proliferation Chemosphere. 25: 955-958. DOI: 10.1016/0045-6535(92)90091-5 |
0.38 |
|
| 1992 |
Liu H, Chinnah A, Kemp M, Safe S. Possible interrelationship between TCDD and interleukin-1 as antiproliferative agents in human breast cancer cells Chemosphere. 25: 951-954. DOI: 10.1016/0045-6535(92)90090-E |
0.431 |
|
| 1992 |
Krishnan V, Narisimhan TR, Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as an antiestrogen in MCF-7 human breast cancer cells Chemosphere. 25: 947-950. DOI: 10.1016/0045-6535(92)90089-A |
0.342 |
|
| 1991 |
Astroff B, Rowlands C, Dickerson R, Safe S. 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of 17 beta-estradiol-induced increases in rat uterine epidermal growth factor receptor binding activity and gene expression. Molecular and Cellular Endocrinology. 72: 247-52. PMID 2289633 DOI: 10.1016/0303-7207(90)90149-3 |
0.416 |
|
| 1991 |
Biegel L, Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on cell growth and the secretion of the estrogen-induced 34-, 52- and 160-kDa proteins in human breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 37: 725-32. PMID 2278856 DOI: 10.1016/0960-0760(90)90357-Q |
0.419 |
|
| 1991 |
Astroff B, Safe S. 6-Alkyl-1,3,8-trichlorodibenzofurans as antiestrogens in female Sprague-Dawley rats. Toxicology. 69: 187-97. PMID 1949047 DOI: 10.1016/0300-483X(91)90230-X |
0.391 |
|
| 1991 |
Astroff B, Eldridge B, Safe S. Inhibition of the 17 beta-estradiol-induced and constitutive expression of the cellular protooncogene c-fos by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the female rat uterus. Toxicology Letters. 56: 305-15. PMID 1903567 DOI: 10.1016/0378-4274(91)90159-4 |
0.335 |
|
| 1991 |
Piskorska-Pliszczynska J, Astroff B, Zacharewski T, Harris M, Rosengren R, Morrison V, Safe L, Safe S. Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: characterization of 6-[125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes. Archives of Biochemistry and Biophysics. 284: 193-200. PMID 1846513 DOI: 10.1016/0003-9861(91)90283-O |
0.371 |
|
| 1991 |
Safe S, Astroff B, Harris M, Zacharewski T, Dickerson R, Romkes M, Biegel L. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: characterization and mechanism of action. Pharmacology & Toxicology. 69: 400-9. PMID 1766914 DOI: 10.1111/J.1600-0773.1991.Tb01321.X |
0.511 |
|
| 1991 |
Piskorska-Pliszczynska J, Morrison V, Zacharewski T, Safe S. DNA binding properties of the Ah receptor in wild-type and variant mouse hepatoma cells. Archives of Biochemistry and Biophysics. 290: 362-8. PMID 1656877 DOI: 10.1016/0003-9861(91)90552-T |
0.385 |
|
| 1991 |
Davis D, Safe S. Halogenated aryl hydrocarbon-induced suppression of the in vitro plaque-forming cell response to sheep red blood cells is not dependent on the Ah receptor. Immunopharmacology. 21: 183-90. PMID 1655676 DOI: 10.1016/0162-3109(91)90023-R |
0.414 |
|
| 1991 |
Wang X, Narasimhan TR, Morrison V, Safe S. In situ and in vitro photoaffinity labeling of the nuclear aryl hydrocarbon receptor from transformed rodent and human cell lines. Archives of Biochemistry and Biophysics. 287: 186-94. PMID 1654803 DOI: 10.1016/0003-9861(91)90405-8 |
0.384 |
|
| 1991 |
Zacharewski T, Harris M, Safe S. Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant mouse Hepa 1c1c7 cells. Biochemical Pharmacology. 41: 1931-9. PMID 1645554 DOI: 10.1016/0006-2952(91)90133-P |
0.428 |
|
| 1990 |
Kelley M, Womack J, Safe S. Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins. Biochemical Pharmacology. 39: 1991-8. PMID 2353939 DOI: 10.1016/0006-2952(90)90620-Z |
0.317 |
|
| 1990 |
Harris M, Zacharewski T, Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells. Cancer Research. 50: 3579-84. PMID 2340506 |
0.332 |
|
| 1990 |
Harris M, Zacharewski T, Piskorska-Pliszczynska J, Rosengren R, Safe S. Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related congeners: mechanistic studies. Toxicology and Applied Pharmacology. 105: 243-53. PMID 2219118 DOI: 10.1016/0041-008X(90)90186-X |
0.38 |
|
| 1990 |
Merchant M, Arellano L, Safe S. The mechanism of action of alpha-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression. Archives of Biochemistry and Biophysics. 281: 84-9. PMID 2166479 DOI: 10.1016/0003-9861(90)90416-V |
0.359 |
|
| 1990 |
Davis D, Safe S. Immunosuppressive activities of polychlorinated biphenyls in C57BL/6N mice: structure-activity relationships as Ah receptor agonists and partial antagonists. Toxicology. 63: 97-111. PMID 2166363 DOI: 10.1016/0300-483X(90)90072-O |
0.322 |
|
| 1990 |
Randerath K, Putman KL, Randerath E, Zacharewski T, Harris M, Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on I-compounds in hepatic DNA of Sprague-Dawley rats: sex-specific effects and structure-activity relationships. Toxicology and Applied Pharmacology. 103: 271-80. PMID 2158676 DOI: 10.1016/0041-008X(90)90229-N |
0.31 |
|
| 1990 |
Astroff B, Safe S. 2,3,7,8-Tetrachlorodibenzo-p-dioxin as an antiestrogen: effect on rat uterine peroxidase activity. Biochemical Pharmacology. 39: 485-8. PMID 2154986 DOI: 10.1016/0006-2952(90)90054-O |
0.397 |
|
| 1990 |
Safe S. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Critical Reviews in Toxicology. 21: 51-88. PMID 2124811 DOI: 10.3109/10408449009089873 |
0.318 |
|
| 1990 |
Howie L, Dickerson R, Davis D, Safe S. Immunosuppressive and monooxygenase induction activities of polychlorinated diphenyl ether congeners in C57BL/6N mice: quantitative structure-activity relationships. Toxicology and Applied Pharmacology. 105: 254-63. PMID 2120796 DOI: 10.1016/0041-008X(90)90187-Y |
0.365 |
|
| 1990 |
Bunce NJ, Landers JP, Schneider UA, Safe SH, Zacharewski TR. Chlorinated trans stilbenes: Competitive binding to the ah receptor, induction of cytochrome p-450 monooxygenase activity and partial 2, 3, 7, 8-TCDD antagonism Toxicological & Environmental Chemistry. 28: 217-229. DOI: 10.1080/02772249009357605 |
0.591 |
|
| 1990 |
DICKERSON R, HOWIE L, DAVIS D, SAFE S. The Structure-Dependent Effects of Heptachlorodibenzofuran Isomers in Male C57BL/6 Mice: Immunotoxicity and onooxygenase Enzyme Induction Toxicological Sciences. 15: 298-307. DOI: 10.1016/0272-0590(90)90056-P |
0.317 |
|
| 1989 |
Randerath K, Putman KL, Randerath E, Mason G, Kelley M, Safe S. Organ-specific effects of long term feeding of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 1,2,3,7,8-pentachlorodibenzo-p-dioxin on I-compounds in hepatic and renal DNA of female Sprague-Dawley rats. Carcinogenesis. 9: 2285-9. PMID 3191574 DOI: 10.1093/Carcin/9.12.2285 |
0.3 |
|
| 1989 |
Bannister R, Biegel L, Davis D, Astroff B, Safe S. 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice. Toxicology. 54: 139-50. PMID 2922766 DOI: 10.1016/0300-483X(89)90040-1 |
0.362 |
|
| 1989 |
Piskorska-Pliszczynska J, Safe S. Radioligand-dependent differences in the molecular properties of the mouse and rat hepatic aryl hydrocarbon receptor complexes. Archives of Biochemistry and Biophysics. 267: 372-83. PMID 2848453 DOI: 10.1016/0003-9861(88)90043-4 |
0.304 |
|
| 1989 |
Safe S, Mason G, Sawyer T, Zacharewski T, Harris M, Yao C, Keys B, Farrell K, Holcomb M, Davis D. Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review. Toxicology and Industrial Health. 5: 757-75. PMID 2683222 DOI: 10.1177/074823378900500513 |
0.343 |
|
| 1989 |
Astroff B, Safe S. 6-substituted-1,3,8-trichlorodibenzofurans as 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists in the rat: structure activity relationships. Toxicology. 59: 285-96. PMID 2631297 DOI: 10.1016/0300-483X(89)90198-4 |
0.388 |
|
| 1989 |
Biegel L, Harris M, Davis D, Rosengren R, Safe L, Safe S. 2,2′,4,4′,5,5′-Hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL6J mice Toxicology and Applied Pharmacology. 97: 561-571. PMID 2558429 DOI: 10.1016/0041-008X(89)90261-5 |
0.408 |
|
| 1989 |
Zacharewski T, Harris M, Safe S. Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: mechanistic studies using radiolabeled congeners. Archives of Biochemistry and Biophysics. 272: 344-55. PMID 2546497 DOI: 10.1016/0003-9861(89)90228-2 |
0.398 |
|
| 1989 |
Harris M, Piskorska-Pliszczynska J, Zacharewski T, Romkes M, Safe S. Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor. Cancer Research. 49: 4531-5. PMID 2545344 |
0.337 |
|
| 1989 |
Davis D, Safe S. Dose-response immunotoxicities of commercial polychlorinated biphenyls (PCBs) and their interaction with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology Letters. 48: 35-43. PMID 2501913 DOI: 10.1016/0378-4274(89)90183-5 |
0.308 |
|
| 1989 |
Safe S. Polychlorinated biphenyls (PCBs): mutagenicity and carcinogenicity. Mutation Research. 220: 31-47. PMID 2492077 DOI: 10.1016/0165-1110(89)90007-9 |
0.377 |
|
| 1989 |
Li SMA, Denomme MA, Leece B, Towner R, Safe* S. Hexachlorobenzene: Biochemical effects and synergistic toxic interactions with 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin Toxicological & Environmental Chemistry. 22: 215-227. DOI: 10.1080/02772248909357440 |
0.308 |
|
| 1989 |
Wærn F, Hanberg A, Manzoor E, Safe S, Ahlborg U. Interaction of 6-methyl-1,3,8-trichlorodibenzofuran with tcdd-induced vitamin A reduction Chemosphere. 19: 1005-1008. DOI: 10.1016/0045-6535(89)90449-9 |
0.327 |
|
| 1989 |
Piskorska-Pliszczynska J, Safe S. Radioligand-dependent properties of the Ah receptor from rat and mouse hepatic cytosol Chemosphere. 19: 963-968. DOI: 10.1016/0045-6535(89)90441-4 |
0.306 |
|
| 1989 |
Biegel L, Howie L, Safe S. Polychlorinated biphenyl (PCB) congeners as 2,3,7,8-TCDD antagonists: Teratogenicity studies Chemosphere. 19: 955-958. DOI: 10.1016/0045-6535(89)90439-6 |
0.323 |
|
| 1989 |
Bannister R, Davis D, Biegel L, Astroff B, Safe S. 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-TCDD antagonist in C57BL/6 mice Chemosphere. 19: 949-953. DOI: 10.1016/0045-6535(89)90438-4 |
0.323 |
|
| 1989 |
Safe S, Davis D, Romkes M, Yao C, Keyes B, Piskorska-Pliszczynska J, Farrell K, Mason G, Denomme M, Safe L, Zmudzka B, Holcomb M. Development and validation of in vitro bioassays for 2,3,7,8-TCDD equivalents Chemosphere. 19: 853-860. DOI: 10.1016/0045-6535(89)90421-9 |
0.326 |
|
| 1989 |
Astroff B, Romkes M, Safe S. Mechanism of action of 2,3,7,8-tcdd and 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) as antiestrogens in the female rat Chemosphere. 19: 785-788. DOI: 10.1016/0045-6535(89)90409-8 |
0.417 |
|
| 1989 |
Harris M, Zacharewski T, Astroff B, Kamps C, Safe S. Characterization of 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-TCDD antagonist in male rats: induction of monooxygenases Chemosphere. 19: 769-772. DOI: 10.1016/0045-6535(89)90406-2 |
0.36 |
|
| 1989 |
Safe S. Risk assessment of PCDDs and PCDFs based on in vitro and in vivo bioassays Chemosphere. 19: 609-613. DOI: 10.1016/0045-6535(89)90379-2 |
0.377 |
|
| 1989 |
Safe S, Zacharewski T, Safe L, Harris M, Yao C, Holcomb M. Validation of the AHH indoction bioassay for the determination of 2,3,7,8-TCDD toxic equivalents Chemosphere. 18: 941-946. DOI: 10.1016/0045-6535(89)90221-X |
0.323 |
|
| 1989 |
Romkes M, Safe S. Comparative effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and progesterone on estrogenic responses in rats Chemosphere. 18: 745-751. DOI: 10.1016/0045-6535(89)90191-4 |
0.389 |
|
| 1989 |
Safe S, Bannister R, Davis D, Haake JM, Zacharewski T, Mayura K, Phillips TD. Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in mice Chemosphere. 18: 709-714. DOI: 10.1016/0045-6535(89)90186-0 |
0.413 |
|
| 1989 |
Zacharewski T, Harris M, Safe S, Thoma H, Hauschulz G, Knorr E, Hutzinger O. Applications of the in vitro AHH induction bioassay for determining 2,3,7,8-TCDD equivalents: Pyrolyzed flame retardant mixtures Chemosphere. 18: 383-387. DOI: 10.1016/0045-6535(89)90144-6 |
0.311 |
|
| 1988 |
Harris M, Kamps C, Safe S. Role of the 4-5S binding protein in the induction of aryl hydrocarbon hydroxylase in the rat. Carcinogenesis. 9: 1475-9. PMID 3402044 DOI: 10.1093/Carcin/9.8.1475 |
0.319 |
|
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