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David H. Sherman - Publications

Affiliations: 
Medicinal Chemistry University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
cryptophycin anticancer drugs
Website:
http://www.cancer.med.umich.edu/news/cope-scholar09.shtml
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Year Citation  Score
2023 Yancey CE, Yu F, Tripathi A, Sherman DH, Dick GJ. Expression of Biosynthetic Gene Clusters in Natural Populations Suggests Temporally Dynamic Synthesis of Novel and Known Secondary Metabolites in Western Lake Erie. Applied and Environmental Microbiology. e0209222. PMID 37070981 DOI: 10.1128/aem.02092-22  0.684
2022 Kelly SP, Shende VV, Flynn AR, Dan Q, Ye Y, Smith JL, Tsukamoto S, Sigman MS, Sherman DH. Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (-)-Eurotiumin A. Journal of the American Chemical Society. PMID 36223664 DOI: 10.1021/jacs.2c06631  0.327
2022 Yancey CE, Smith DJ, Den Uyl PA, Mohamed OG, Yu F, Ruberg SA, Chaffin JD, Goodwin KD, Tripathi A, Sherman DH, Dick GJ. Metagenomic and Metatranscriptomic Insights into Population Diversity of Blooms: Spatial and Temporal Dynamics of Genotypes, Including a Partial Operon That Can Be Abundant and Expressed. Applied and Environmental Microbiology. e0246421. PMID 35438519 DOI: 10.1128/aem.02464-21  0.657
2021 Mohamed OG, Dorandish S, Lindow R, Steltz M, Shoukat I, Shoukat M, Chehade H, Baghdadi S, McAlister-Raeburn M, Kamal A, Abebe D, Ali K, Ivy C, Antonova M, Schultz P, ... ... Sherman D, et al. Identification of a New Antimicrobial, Desertomycin H, Utilizing a Modified Crowded Plate Technique. Marine Drugs. 19. PMID 34436264 DOI: 10.3390/md19080424  0.683
2021 Hohlman RM, Newmister SA, Sanders JN, Khatri Y, Li S, Keramati NR, Lowell AN, Houk KN, Sherman DH. Structural diversification of hapalindole and fischerindole natural products via cascade biocatalysis. Acs Catalysis. 11: 4670-4681. PMID 34354850 DOI: 10.1021/acscatal.0c05656  0.36
2021 Hohlman RM, Sherman DH. Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity. Natural Product Reports. PMID 34032254 DOI: 10.1039/d1np00007a  0.338
2020 Ye Y, Du L, Zhang X, Newmister SA, McCauley M, Alegre-Requena JV, Zhang W, Mu S, Minami A, Fraley AE, Adrover-Castellano ML, Carney NA, Shende VV, Qi F, Oikawa H, ... ... Sherman DH, et al. Fungal-derived brevianamide assembly by a stereoselective semipinacolase. Nature Catalysis. 3: 497-506. PMID 32923978 DOI: 10.1038/s41929-020-0454-9  0.63
2020 Painter MM, Zimmerman GE, Merlino MS, Robertson AW, Terry VH, Ren X, McLeod MR, Gomez-Rodriguez L, Garcia KA, Leonard JA, Leopold KE, Neevel AJ, Lubow J, Olson E, Piechocka-Trocha A, ... ... Sherman DH, et al. Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. PMID 32900948 DOI: 10.1073/Pnas.2008615117  0.647
2020 Gómez-Rodríguez L, Schultz PJ, Tamayo-Castillo G, Dotson GD, Sherman DH, Tripathi A. Adipostatins E-J, New Potent Antimicrobials Identified as Inhibitors of Coenzyme-A Biosynthesis. Tetrahedron Letters. 61. PMID 32863451 DOI: 10.1016/J.Tetlet.2019.151469  0.71
2020 Shende VV, Khatri Y, Newmister SA, Sanders J, Lindovska P, Yu F, Doyon T, Kim J, Houk KN, Movassaghi M, Sherman DH. Structure and Function of NzeB, a Versatile C-C and C-N Bond Forming Diketopiperazine Dimerase. Journal of the American Chemical Society. PMID 32786740 DOI: 10.1021/Jacs.0C06312  0.387
2020 Sherman DH, Koch AA, Schmidt J, Lowell A, Hansen D, Coburn K, Chemler J. Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases. Angewandte Chemie (International Ed. in English). PMID 32357274 DOI: 10.1002/Anie.202004991  0.413
2020 Khatri Y, Hohlman RM, Mendoza J, Li S, Lowell AN, Asahara H, Sherman DH. Multi-component microscale biosynthesis of unnatural cyanobacterial indole alkaloids. Acs Synthetic Biology. PMID 32302487 DOI: 10.1021/Acssynbio.0C00038  0.468
2020 Fraley AE, Tran HT, Kelly SP, Newmister SA, Tripathi A, Kato H, Tsukamoto S, Du L, Li S, Williams RM, Sherman DH. Flavin-Dependent Monooxygenases NotI and NotI' Mediate Spiro-Oxindole Formation in Biosynthesis of the Notoamides. Chembiochem : a European Journal of Chemical Biology. PMID 32246875 DOI: 10.1002/Cbic.202000004  0.784
2020 Fraley AE, Sherman DH. Enzyme evolution in fungal indole alkaloid biosynthesis. The Febs Journal. PMID 32118354 DOI: 10.1111/Febs.15270  0.402
2020 Li S, Newmister SA, Lowell AN, Zi J, Chappell CR, Yu F, Hohlman RM, Orjala J, Williams RM, Sherman DH. Control of stereoselectivity in diverse hapalindole metabolites is mediated by cofactor induced combinatorial pairing of Stig cyclases. Angewandte Chemie (International Ed. in English). PMID 32052896 DOI: 10.1002/Anie.201913686  0.334
2020 Thielman JR, Sherman DH, Williams RM. Stereoselective Synthesis of Baulamycin A. The Journal of Organic Chemistry. PMID 31970985 DOI: 10.1021/Acs.Joc.9B03443  0.391
2020 Schmidt JJ, Khatri Y, Brody SI, Zhu C, Pietraszkiewicz H, Valeriote FA, Sherman DH. A Versatile Chemoenzymatic Synthesis for the Discovery of Potent Cryptophycin Analogs. Acs Chemical Biology. PMID 31961651 DOI: 10.1021/Acschembio.9B00998  0.462
2020 Fraley A, Caddell Haatveit K, Ye Y, Kelly SP, Newmister SA, Yu F, Williams RM, Smith JL, Houk KN, Sherman DH. Molecular basis for spirocycle formation in the paraherquamide biosynthetic pathway. Journal of the American Chemical Society. PMID 31904957 DOI: 10.2210/Pdb6Pvi/Pdb  0.403
2020 Gómez-Rodríguez L, Schultz PJ, Tamayo-Castillo G, Dotson GD, Sherman DH, Tripathi A. Adipostatins E-J, new potent antimicrobials identified as inhibitors of coenzyme-A biosynthesis Tetrahedron Letters. 61: 151469. DOI: 10.1016/j.tetlet.2019.151469  0.638
2020 Fraley AE, Tran HT, Kelly SP, Newmister SA, Tripathi A, Kato H, Tsukamoto S, Du L, Li S, Williams RM, Sherman DH. Cover Feature: Flavin‐Dependent Monooxygenases NotI and NotI′ Mediate Spiro‐Oxindole Formation in Biosynthesis of the Notoamides (ChemBioChem 17/2020) Chembiochem. 21: 2382-2382. DOI: 10.1002/Cbic.202000548  0.741
2019 Skiba MA, Tran CL, Dan Q, Sikkema AP, Klaver Z, Gerwick WH, Sherman DH, Smith JL. Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis. Structure (London, England : 1993). PMID 31785925 DOI: 10.1016/J.Str.2019.11.004  0.435
2019 Dan Q, Newmister SA, Klas KR, Fraley AE, McAfoos TJ, Somoza AD, Sunderhaus JD, Ye Y, Shende VV, Yu F, Sanders JN, Brown WC, Zhao L, Paton RS, Houk KN, ... ... Sherman DH, et al. Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase. Nature Chemistry. PMID 31548667 DOI: 10.1038/S41557-019-0326-6  0.436
2019 Li T, Tripathi A, Yu F, Sherman DH, Rao A. DDAP: docking domain affinity and biosynthetic pathway prediction tool for type I polyketide synthases. Bioinformatics (Oxford, England). PMID 31504190 DOI: 10.1093/Bioinformatics/Btz677  0.669
2019 DeMars MD, Samora NL, Yang S, Garcia-Borràs M, Sanders JN, Houk KN, Podust LM, Sherman DH. Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450. The Journal of Biological Chemistry. PMID 31488542 DOI: 10.1074/Jbc.Ra119.010352  0.393
2019 Knoot CJ, Khatri Y, Hohlman RM, Sherman DH, Pakrasi HB. Engineered production of hapalindole alkaloids in the cyanobacterium Synechococcus sp. UTEX 2973. Acs Synthetic Biology. PMID 31284716 DOI: 10.1021/Acssynbio.9B00229  0.442
2019 Kalkreuter E, CroweTipton JM, Lowell AN, Sherman DH, Williams GJ. Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units. Journal of the American Chemical Society. PMID 30676722 DOI: 10.1021/Jacs.8B10521  0.352
2019 Dan Q, Newmister SA, Klas KR, Fraley AE, Paton RS, Houk KN, Williams RM, Sherman DH, Smith JL. Evolution of a bifunctional reductase/Diels–Alderase for fungal indole alkaloid biosynthesis Acta Crystallographica Section a Foundations and Advances. 75: a244-a245. DOI: 10.1107/S0108767319097599  0.38
2018 Kai A, Kato H, Sherman DH, Williams RM, Tsukamoto S. Isolation of a new indoxyl alkaloid, Amoenamide B, from NRRL 35600: biosynthetic implications and correction of the structure of Speramide B. Tetrahedron Letters. 50: 4236-4240. PMID 30765898 DOI: 10.1016/J.Tetlet.2018.10.034  0.316
2018 Skiba MA, Bivins MM, Schultz JR, Bernard SM, Fiers WD, Dan Q, Kulkarni S, Wipf P, Gerwick WH, Sherman DH, Aldrich CC, Smith JL. Structural Basis of Polyketide Synthase O-Methylation. Acs Chemical Biology. PMID 30489068 DOI: 10.1021/Acschembio.8B00687  0.533
2018 Hagan AK, Plotnick YM, Dingle RE, Mendel ZI, Cendrowski SR, Sherman DH, Tripathi A, Hanna PC. Petrobactin Protects against Oxidative Stress and Enhances Sporulation Efficiency in Bacillus anthracis Sterne. Mbio. 9. PMID 30401780 DOI: 10.1128/Mbio.02079-18  0.665
2018 Newmister SA, Romminger S, Schmidt JJ, Williams RM, Smith JL, Berlinck RGS, Sherman DH. Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway. Organic & Biomolecular Chemistry. PMID 30141817 DOI: 10.1039/C8Ob01565A  0.391
2018 McDonnell KJ, Chemler JA, Bartels PL, O'Brien E, Marvin ML, Ortega J, Stern RH, Raskin L, Li GM, Sherman DH, Barton JK, Gruber SB. A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S] cluster. Nature Chemistry. PMID 29915346 DOI: 10.1038/S41557-018-0068-X  0.301
2018 Slocum ST, Lowell AN, Tripathi AN, Shende VV, Smith JL, Sherman DH. Chemoenzymatic Dissection of Polyketide β-Branching in the Bryostatin Pathway. Methods in Enzymology. 604: 207-236. PMID 29779653 DOI: 10.1016/Bs.Mie.2018.01.034  0.405
2018 Sherman DH, Tripathi A, Park SR, Sikkema A, Cho HJ, Wu J, Lee B, Xi C, Smith JL. A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity by the Cahuitamycin Starter Unit Activating Enzyme CahJ. Chembiochem : a European Journal of Chemical Biology. PMID 29742306 DOI: 10.1002/Cbic.201800233  0.734
2018 Fraley AE, Sherman DH. Halogenase engineering and its utility in medicinal chemistry. Bioorganic & Medicinal Chemistry Letters. PMID 29731363 DOI: 10.1016/J.Bmcl.2018.04.066  0.35
2018 Skiba MA, Sikkema AP, Moss NA, Lowell AN, Su M, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL. Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module. Acs Chemical Biology. PMID 29701944 DOI: 10.1021/Acschembio.8B00252  0.405
2018 Klas KR, Kato H, Frisvad JC, Yu F, Newmister SA, Fraley AE, Sherman DH, Tsukamoto S, Williams RM. Structural and stereochemical diversity in prenylated indole alkaloids containing the bicyclo[2.2.2]diazaoctane ring system from marine and terrestrial fungi. Natural Product Reports. PMID 29632911 DOI: 10.1039/C7Np00042A  0.406
2018 Newmister SA, Li S, Garcia-Borràs M, Sanders JN, Yang S, Lowell AN, Yu F, Smith JL, Williams RM, Houk KN, Sherman DH. Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis. Nature Chemical Biology. PMID 29531360 DOI: 10.1038/S41589-018-0003-X  0.415
2018 Tripathi A, Park SR, Sikkema AP, Cho HJ, Wu J, Lee B, Xi C, Smith JL, Sherman DH. Cover Feature: A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity of the Cahuitamycin Starter Unit-Activating Enzyme CahJ (ChemBioChem 15/2018) Chembiochem. 19: 1571-1571. DOI: 10.1002/Cbic.201800363  0.691
2017 Sugimoto K, Sadahiro Y, Kagiyama I, Kato H, Sherman DH, Williams RM, Tsukamoto S. Isolation of amoenamide A and five antipodal prenylated alkaloids fromNRRL 35600. Tetrahedron Letters. 58: 2797-2800. PMID 29622844 DOI: 10.1016/J.Tetlet.2017.05.057  0.307
2017 Gilbert MM, DeMars MD, Yang S, Grandner JM, Wang S, Wang H, Narayan ARH, Sherman DH, Houk KN, Montgomery J. Synthesis of Diverse 11- and 12-Membered Macrolactones from a Common Linear Substrate Using a Single Biocatalyst. Acs Central Science. 3: 1304-1310. PMID 29296671 DOI: 10.1021/Acscentsci.7B00450  0.341
2017 Mike LA, Tripathi A, Blankenship CM, Saluk A, Schultz PJ, Tamayo-Castillo G, Sherman DH, Mobley HLT. Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments. Chemical Communications (Cambridge, England). PMID 29139494 DOI: 10.1039/C7Cc07732G  0.693
2017 Skiba MA, Sikkema AP, Moss NA, Tran CL, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL. A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit. Acs Chemical Biology. PMID 29096064 DOI: 10.1021/Acschembio.7B00746  0.374
2017 Hagan AK, Tripathi A, Berger D, Sherman DH, Hanna PC. Erratum for Hagan et al., "Petrobactin Is Exported from Bacillus anthracis by the RND-Type Exporter ApeX". Mbio. 8. PMID 29042503 DOI: 10.1128/Mbio.01686-17  0.623
2017 Almutairi MM, Svetlov MS, Hansen DA, Khabibullina NF, Klepacki D, Kang HY, Sherman DH, Vázquez-Laslop N, Polikanov YS, Mankin AS. Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins. Nucleic Acids Research. 45: 9573-9582. PMID 28934499 DOI: 10.1093/Nar/Gkx673  0.383
2017 Hagan AK, Tripathi A, Berger D, Sherman DH, Hanna PC. Petrobactin Is Exported from Bacillus anthracis by the RND-Type Exporter ApeX. Mbio. 8. PMID 28900020 DOI: 10.1128/Mbio.01238-17  0.681
2017 Hansen DA, Koch AA, Sherman DH. Identification of a thioesterase bottleneck in the pikromycin pathway through full-module processing of unnatural pentaketides. Journal of the American Chemical Society. PMID 28836772 DOI: 10.1021/Jacs.7B06432  0.429
2017 Koch AA, Hansen DA, Shende VV, Furan LR, Houk KN, Jiménez-Osés G, Sherman DH. A single active site mutation in the pikromycin thioesterase generates a more effective macrocyclization catalyst. Journal of the American Chemical Society. PMID 28836768 DOI: 10.1021/Jacs.7B06436  0.374
2017 Fraley AE, Garcia-Borràs M, Tripathi A, Khare D, Mercado-Marin EV, Tran H, Dan Q, Webb G, Watts K, Crews P, Sarpong R, Williams RM, Smith JL, Houk KN, Sherman DH. Function and structure of MalA/MalA', iterative halogenases for late-stage C-H functionalization of indole alkaloids. Journal of the American Chemical Society. PMID 28777910 DOI: 10.1021/Jacs.7B06773  0.817
2017 Paul S, Ludeña Y, Villena GK, Yu F, Sherman DH, Gutiérrez-Correa M. High-quality draft genome sequence of a biofilm forming lignocellulolytic Aspergillus niger strain ATCC 10864. Standards in Genomic Sciences. 12: 37. PMID 28725336 DOI: 10.1186/S40793-017-0254-2  0.343
2017 Tay JH, Argüelles AJ, DeMars MD, Zimmerman PM, Sherman DH, Nagorny P. Regiodivergent Glycosylations of 6-Deoxy-erythronolide B and Oleandomycin-Derived Macrolactones Enabled by Chiral Acid Catalysis. Journal of the American Chemical Society. PMID 28627172 DOI: 10.1021/Jacs.7B03198  0.303
2017 Lowell AN, DeMars MD, Slocum ST, Yu F, Anand K, Chemler JA, Korakavi N, Priessnitz JK, Park SR, Koch AA, Schultz PJ, Sherman DH. Chemoenzymatic total synthesis and structural diversification of tylactone-based macrolide antibiotics through late-stage polyketide assembly, tailoring, and C-H functionalization. Journal of the American Chemical Society. PMID 28525276 DOI: 10.1021/Jacs.7B02875  0.402
2017 Tietz DR, Podust LM, Sherman DH, Pochapsky TC. Solution conformations and dynamics of substrate-bound cytochrome P450 MycG. Biochemistry. PMID 28488849 DOI: 10.1021/Acs.Biochem.7B00291  0.304
2017 Kinnel RB, Esquenazi E, Leao T, Moss N, Mevers E, Pereira AR, Monroe EA, Korobeynikov A, Murray TF, Sherman D, Gerwick L, Dorrestein PC, Gerwick WH. A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens. Journal of Natural Products. PMID 28448144 DOI: 10.1021/Acs.Jnatprod.7B00019  0.405
2017 Li Z, Du L, Zhang W, Zhang X, Jiang Y, Liu K, Men P, Xu H, Fortman JL, Sherman DH, Yu B, Gao S, Li S. Complete Elucidation of the Late Steps of Bafilomycin Biosynthesis in Streptomyces lohii. The Journal of Biological Chemistry. PMID 28292933 DOI: 10.1074/Jbc.M116.751255  0.833
2017 Li S, Lowell AN, Newmister SA, Yu F, Williams RM, Sherman DH. Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids. Nature Chemical Biology. PMID 28288107 DOI: 10.1038/Nchembio.2327  0.363
2017 Koryakina I, Kasey C, McArthur JB, Lowell AN, Chemler JA, Li S, Hansen DA, Sherman DH, Williams GJ. Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering. Acs Chemical Biology. 12: 114-123. PMID 28103677 DOI: 10.1021/Acschembio.6B00732  0.398
2017 Mike L, Tripathi A, Sherman D, Mobley H. PD12-01 A NOVEL FAMILY OF NATURAL PRODUCTS THAT TARGETS UROPATHOGENIC ESCHERISCHIA COLI IRON ACQUISITION Journal of Urology. 197. DOI: 10.1016/J.Juro.2017.02.676  0.66
2016 Zhang X, Li Z, Du L, Chlipala GE, Lopez PC, Zhang W, Sherman DH, Li S. Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis. Tetrahedron Letters. 57: 5919-5923. PMID 28989201 DOI: 10.1016/J.Tetlet.2016.11.080  0.661
2016 Fiers WD, Dodge GJ, Sherman DH, Smith JL, Aldrich CC. Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis. Journal of the American Chemical Society. 138: 16024-16036. PMID 27960309 DOI: 10.1021/Jacs.6B09748  0.612
2016 Chatterjee P, Davis E, Yu F, James S, Wildschutte JH, Wiegmann DD, Sherman DH, McKay RM, LiPuma JJ, Wildschutte H. Environmental pseudomonads inhibit cystic fibrosis patient-derived Pseudomonas aeruginosa. Applied and Environmental Microbiology. PMID 27881418 DOI: 10.1128/Aem.02701-16  0.313
2016 Skiba MA, Sikkema AP, Fiers WD, Gerwick WH, Sherman DH, Aldrich CC, Smith JL. Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase. Acs Chemical Biology. PMID 27723289 DOI: 10.1021/Acschembio.6B00759  0.575
2016 Maloney FP, Gerwick L, Gerwick WH, Sherman DH, Smith JL. Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proceedings of the National Academy of Sciences of the United States of America. PMID 27573844 DOI: 10.1073/Pnas.1607210113  0.399
2016 Newmister SA, Gober CM, Romminger S, Yu F, Tripathi A, Parra LL, Williams RM, Berlinck RG, Joullié MM, Sherman DH. OxaD, a versatile indolic nitrone synthase from the marine-derived fungus Penicillium oxalicum F30. Journal of the American Chemical Society. PMID 27505044 DOI: 10.1021/Jacs.6B04915  0.716
2016 DeMars MD, Sheng F, Park SR, Lowell AN, Podust LM, Sherman DH. Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway. Acs Chemical Biology. PMID 27420774 DOI: 10.1021/Acschembio.6B00479  0.417
2016 Tripathi A, Choi SS, Sherman DH, Kim ES. Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412. Journal of Industrial Microbiology & Biotechnology. PMID 27277081 DOI: 10.1007/S10295-016-1790-2  0.718
2016 Park SR, Tripathi A, Wu J, Schultz PJ, Yim I, McQuade TJ, Yu F, Arevang CJ, Mensah AY, Tamayo-Castillo G, Xi C, Sherman DH. Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway. Nature Communications. 7: 10710. PMID 26880271 DOI: 10.1038/Ncomms10710  0.708
2016 Bertin MJ, Vulpanovici A, Monroe EA, Korobeynikov A, Sherman DH, Gerwick L, Gerwick WH. The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide. Chembiochem : a European Journal of Chemical Biology. 17: 164-73. PMID 26769357 DOI: 10.1002/Cbic.201500467  0.39
2016 Kleigrewe K, Gerwick L, Sherman DH, Gerwick WH. Unique marine derived cyanobacterial biosynthetic genes for chemical diversity. Natural Product Reports. PMID 26758451 DOI: 10.1039/C5Np00097A  0.451
2015 Kagiyama I, Kato H, Nehira T, Frisvad JC, Sherman DH, Williams RM, Tsukamoto S. Taichunamides: Prenylated Indole Alkaloids from Aspergillus taichungensis (IBT 19404). Angewandte Chemie (International Ed. in English). PMID 26644336 DOI: 10.1002/Anie.201509462  0.353
2015 Li S, Lowell AN, Yu F, Raveh A, Newmister SA, Bair N, Schaub JM, Williams RM, Sherman DH. Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C-C Bond-Forming Cascade. Journal of the American Chemical Society. PMID 26629885 DOI: 10.1021/Jacs.5B10136  0.375
2015 Sidhu A, Miller JR, Tripathi A, Garshott DM, Brownell AL, Chiego DJ, Arevang C, Zeng Q, Jackson LC, Bechler SA, Callaghan MU, Yoo GH, Sethi S, Lin HS, Callaghan JH, ... ... Sherman DH, et al. Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis. Acs Medicinal Chemistry Letters. 6: 1122-1127. PMID 26617965 DOI: 10.1021/Acsmedchemlett.5B00133  0.656
2015 Khare D, Hale WA, Tripathi A, Gu L, Sherman DH, Gerwick WH, Håkansson K, Smith JL. Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase. Structure (London, England : 1993). PMID 26526850 DOI: 10.1016/J.Str.2015.09.013  0.815
2015 Klas K, Tsukamoto S, Sherman DH, Williams RM. Natural Diels-Alderases: Elusive and Irresistable. The Journal of Organic Chemistry. PMID 26495876 DOI: 10.1021/Acs.Joc.5B01951  0.344
2015 Cheng KC, Cao S, Raveh A, MacArthur R, Dranchak P, Chlipala G, Okoneski MT, Guha R, Eastman RT, Yuan J, Schultz PJ, Su XZ, Tamayo-Castillo G, Matainaho T, Clardy J, ... Sherman DH, et al. Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts. Journal of Natural Products. PMID 26465675 DOI: 10.1021/Acs.Jnatprod.5B00489  0.352
2015 Almutairi MM, Park SR, Rose S, Hansen DA, Vázquez-Laslop N, Douthwaite S, Sherman DH, Mankin AS. Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides. Proceedings of the National Academy of Sciences of the United States of America. PMID 26438831 DOI: 10.1073/Pnas.1512090112  0.32
2015 Cruz PG, Fribley AM, Miller JR, Larsen MJ, Schultz PJ, Jacob RT, Tamayo-Castillo G, Kaufman RJ, Sherman DH. Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts. Acs Medicinal Chemistry Letters. 6: 877-81. PMID 26288688 DOI: 10.1021/Acsmedchemlett.5B00127  0.309
2015 Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Sherman DH, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/Nchembio.1890  0.451
2015 Chemler JA, Tripathi A, Hansen DA, O'Neil-Johnson M, Williams RB, Starks C, Park SR, Sherman DH. Evolution of Efficient Modular Polyketide Synthases by Homeologous Recombination. Journal of the American Chemical Society. PMID 26230368 DOI: 10.1021/Jacs.5B04842  0.749
2015 Boudreau PD, Monroe EA, Mehrotra S, Desfor S, Korobeynikov A, Sherman DH, Murray TF, Gerwick L, Dorrestein PC, Gerwick WH. Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows. Plos One. 10: e0133297. PMID 26222584 DOI: 10.1371/Journal.Pone.0133297  0.397
2015 Narayan AR, Jiménez-Osés G, Liu P, Negretti S, Zhao W, Gilbert MM, Ramabhadran RO, Yang YF, Furan LR, Li Z, Podust LM, Montgomery J, Houk KN, Sherman DH. Enzymatic hydroxylation of an unactivated methylene C-H bond guided by molecular dynamics simulations. Nature Chemistry. 7: 653-60. PMID 26201742 DOI: 10.1038/Nchem.2285  0.788
2015 Sherman DH, Tsukamoto S, Williams RM. ORGANIC SYNTHESIS. Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence". Science (New York, N.Y.). 349: 149. PMID 26160938 DOI: 10.1126/Science.Aaa9349  0.32
2015 Kleigrewe K, Almaliti J, Tian IY, Kinnel RB, Korobeynikov A, Monroe EA, Duggan BM, Di Marzo V, Sherman DH, Dorrestein PC, Gerwick L, Gerwick WH. Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria. Journal of Natural Products. PMID 26149623 DOI: 10.1021/Acs.Jnatprod.5B00301  0.371
2015 Lowell AN, Santoro N, Swaney SM, McQuade TJ, Schultz PJ, Larsen MJ, Sherman DH. Microscale Adaptation of In Vitro Transcription/Translation for High-Throughput Screening of Natural Product Extract Libraries. Chemical Biology & Drug Design. PMID 26147927 DOI: 10.1111/Cbdd.12614  0.332
2015 Schofield MM, Jain S, Porat D, Dick GJ, Sherman DH. Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743. Environmental Microbiology. PMID 26013440 DOI: 10.1111/1462-2920.12908  0.353
2015 Smith JL, Skiniotis G, Sherman DH. Architecture of the polyketide synthase module: surprises from electron cryo-microscopy. Current Opinion in Structural Biology. 31: 9-19. PMID 25791608 DOI: 10.1016/J.Sbi.2015.02.014  0.367
2015 Kato H, Nakahara T, Yamaguchi M, Kagiyama I, Finefield JM, Sunderhaus JD, Sherman DH, Williams RM, Tsukamoto S. Bioconversion of 6-epi-Notoamide T Produces Metabolites of Unprecedented Structures in a Marine-derived Aspergillus sp. Tetrahedron Letters. 56: 247-251. PMID 25767298 DOI: 10.1016/J.Tetlet.2014.11.083  0.339
2015 Hansen DA, Koch AA, Sherman DH. Substrate controlled divergence in polyketide synthase catalysis. Journal of the American Chemical Society. 137: 3735-8. PMID 25730816 DOI: 10.1021/Ja511743N  0.407
2015 Bernard SM, Akey DL, Tripathi A, Park SR, Konwerski JR, Anzai Y, Li S, Kato F, Sherman DH, Smith JL. Structural basis of substrate specificity and regiochemistry in the MycF/TylF family of sugar O-methyltransferases. Acs Chemical Biology. 10: 1340-51. PMID 25692963 DOI: 10.1021/Cb5009348  0.794
2015 Delekta PC, Raveh A, Larsen MJ, Schultz PJ, Tamayo-Castillo G, Sherman DH, Miller DJ. The combined use of alphavirus replicons and pseudoinfectious particles for the discovery of antivirals derived from natural products. Journal of Biomolecular Screening. 20: 673-80. PMID 25550354 DOI: 10.1177/1087057114564868  0.304
2015 Shinde PB, Oh HS, Choi H, Rathwell K, Ban YH, Kim EJ, Yang I, Lee DG, Sherman DH, Kang HY, Yoon YJ. Chemoenzymatic Synthesis of Glycosylated Macrolactam Analogues of the Macrolide Antibiotic YC-17 Advanced Synthesis and Catalysis. 357: 2697-2711. DOI: 10.1002/Adsc.201500250  0.322
2014 Vargas-Asensio G, Pinto-Tomas A, Rivera B, Hernandez M, Hernandez C, Soto-Montero S, Murillo C, Sherman DH, Tamayo-Castillo G. Uncovering the cultivable microbial diversity of costa rican beetles and its ability to break down plant cell wall components. Plos One. 9: e113303. PMID 25411842 DOI: 10.1371/Journal.Pone.0113303  0.332
2014 Raveh A, Schultz PJ, Aschermann L, Carpenter C, Tamayo-Castillo G, Cao S, Clardy J, Neubig RR, Sherman DH, Sjögren B. Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts. Molecular Pharmacology. 86: 406-16. PMID 25086086 DOI: 10.1124/Mol.114.092403  0.32
2014 Whicher JR, Dutta S, Hansen DA, Hale WA, Chemler JA, Dosey AM, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. Structural rearrangements of a polyketide synthase module during its catalytic cycle. Nature. 510: 560-4. PMID 24965656 DOI: 10.1038/Nature13409  0.817
2014 Dutta S, Whicher JR, Hansen DA, Hale WA, Chemler JA, Congdon GR, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. Structure of a modular polyketide synthase. Nature. 510: 512-7. PMID 24965652 DOI: 10.1038/Nature13423  0.816
2014 Newmister SA, Sherman DH. Crystal structures of acyl carrier protein in complex with two catalytic partners show a dynamic role in cellular metabolism. Chembiochem : a European Journal of Chemical Biology. 15: 1079-81. PMID 24771327 DOI: 10.1002/Cbic.201402095  0.317
2014 Walter GM, Raveh A, Mok SA, McQuade TJ, Arevang CJ, Schultz PJ, Smith MC, Asare S, Cruz PG, Wisen S, Matainaho T, Sherman DH, Gestwicki JE. High-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity. Chemical Biology & Drug Design. 83: 440-9. PMID 24636344 DOI: 10.1111/Cbdd.12259  0.321
2014 Negretti S, Narayan AR, Chiou KC, Kells PM, Stachowski JL, Hansen DA, Podust LM, Montgomery J, Sherman DH. Directing group-controlled regioselectivity in an enzymatic C-H bond oxygenation. Journal of the American Chemical Society. 136: 4901-4. PMID 24627965 DOI: 10.1021/Ja5016052  0.787
2014 Zhang W, Liu Y, Yan J, Cao S, Bai F, Yang Y, Huang S, Yao L, Anzai Y, Kato F, Podust LM, Sherman DH, Li S. New reactions and products resulting from alternative interactions between the P450 enzyme and redox partners. Journal of the American Chemical Society. 136: 3640-6. PMID 24521145 DOI: 10.1021/Ja4130302  0.642
2014 Coates RC, Podell S, Korobeynikov A, Lapidus A, Pevzner P, Sherman DH, Allen EE, Gerwick L, Gerwick WH. Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways. Plos One. 9: e85140. PMID 24475038 DOI: 10.1371/Journal.Pone.0085140  0.355
2014 Tripathi A, Schofield MM, Chlipala GE, Schultz PJ, Yim I, Newmister SA, Nusca TD, Scaglione JB, Hanna PC, Tamayo-Castillo G, Sherman DH. Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracis. Journal of the American Chemical Society. 136: 1579-86. PMID 24401083 DOI: 10.1021/Ja4115924  0.8
2014 Tripathi A, Schofield MM, Chlipala GE, Schultz PJ, Yim I, Newmister SA, Nusca TD, Scaglione JB, Hanna PC, Tamayo-Castillo G, Sherman DH. Correction to “Baulamycins A and B, Broad-Spectrum Antibiotics Identified as Inhibitors of Siderophore Biosynthesis in Staphylococcus aureus and Bacillus anthracis” Journal of the American Chemical Society. 136: 10541-10541. DOI: 10.1021/Ja505297X  0.773
2014 Li S, Zhang W, Liu Y, Anzai Y, Kato F, Podust L, Sherman D. Uncovering the broader roles of redox partner proteins for cytochrome P450 enzymes New Biotechnology. 31: S75-S76. DOI: 10.1016/J.Nbt.2014.05.1785  0.594
2013 Raveh A, Delekta PC, Dobry CJ, Peng W, Schultz PJ, Blakely PK, Tai AW, Matainaho T, Irani DN, Sherman DH, Miller DJ. Discovery of potent broad spectrum antivirals derived from marine actinobacteria. Plos One. 8: e82318. PMID 24349254 DOI: 10.1371/Journal.Pone.0082318  0.382
2013 Whicher JR, Smaga SS, Hansen DA, Brown WC, Gerwick WH, Sherman DH, Smith JL. Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis. Chemistry & Biology. 20: 1340-51. PMID 24183970 DOI: 10.1016/J.Chembiol.2013.09.015  0.349
2013 Hansen DA, Rath CM, Eisman EB, Narayan AR, Kittendorf JD, Mortison JD, Yoon YJ, Sherman DH. Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin. Journal of the American Chemical Society. 135: 11232-8. PMID 23866020 DOI: 10.1021/Ja404134F  0.792
2013 Schofield MM, Sherman DH. Meta-omic characterization of prokaryotic gene clusters for natural product biosynthesis. Current Opinion in Biotechnology. 24: 1151-8. PMID 23731715 DOI: 10.1016/J.Copbio.2013.05.001  0.401
2013 Zhang W, Fortman JL, Carlson JC, Yan J, Liu Y, Bai F, Guan W, Jia J, Matainaho T, Sherman DH, Li S. Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii. Chembiochem : a European Journal of Chemical Biology. 14: 301-6. PMID 23362147 DOI: 10.1002/Cbic.201200743  0.795
2013 Narayan AR, Sherman DH. Chemistry. Re-engineering nature's catalysts. Science (New York, N.Y.). 339: 283-4. PMID 23329039 DOI: 10.1126/Science.1233324  0.794
2013 Sunderhaus JD, McAfoos TJ, Finefield JM, Kato H, Li S, Tsukamoto S, Sherman DH, Williams RM. Synthesis and bioconversions of notoamide T: a biosynthetic precursor to stephacidin A and notoamide B. Organic Letters. 15: 22-5. PMID 23249380 DOI: 10.1021/Ol302901P  0.579
2013 Sherman D, Skiniotis G, Smith J, Håkansson K, Dutta S, Whicher J, Hansen D, Hale W, Chemler J, Congdon G, Narayan A. The Structure and Rearrangements of a Complete Polyketide Synthase Module During its Catalytic Cycle Planta Medica. 79. DOI: 10.1055/S-0033-1348499  0.783
2012 Li S, Anand K, Tran H, Yu F, Finefield JM, Sunderhaus JD, McAfoos TJ, Tsukamoto S, Williams RM, Sherman DH. Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways. Medchemcomm. 3: 987-996. PMID 23213353 DOI: 10.1039/C2Md20029E  0.669
2012 Kim EJ, Lee JH, Choi H, Pereira AR, Ban YH, Yoo YJ, Kim E, Park JW, Sherman DH, Gerwick WH, Yoon YJ. Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product. Organic Letters. 14: 5824-7. PMID 23148802 DOI: 10.1021/Ol302575H  0.351
2012 Majmudar CY, Højfeldt JW, Arevang CJ, Pomerantz WC, Gagnon JK, Schultz PJ, Cesa LC, Doss CH, Rowe SP, Vásquez V, Tamayo-Castillo G, Cierpicki T, Brooks CL, Sherman DH, Mapp AK. Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300. Angewandte Chemie (International Ed. in English). 51: 11258-62. PMID 23042634 DOI: 10.1002/Anie.201206815  0.308
2012 McCarthy JG, Eisman EB, Kulkarni S, Gerwick L, Gerwick WH, Wipf P, Sherman DH, Smith JL. Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. Acs Chemical Biology. 7: 1994-2003. PMID 22991895 DOI: 10.1021/Cb300385M  0.417
2012 Li S, Tietz DR, Rutaganira FU, Kells PM, Anzai Y, Kato F, Pochapsky TC, Sherman DH, Podust LM. Substrate recognition by the multifunctional cytochrome P450 MycG in mycinamicin hydroxylation and epoxidation reactions. The Journal of Biological Chemistry. 287: 37880-90. PMID 22952225 DOI: 10.1074/Jbc.M112.410340  0.654
2012 Podust LM, Sherman DH. Diversity of P450 enzymes in the biosynthesis of natural products. Natural Product Reports. 29: 1251-66. PMID 22820933 DOI: 10.1039/C2Np20020A  0.412
2012 Shareef AR, Sherman DH, Montgomery J. Nickel-Catalyzed Regiodivergent Approach to Macrolide Motifs. Chemical Science (Royal Society of Chemistry : 2010). 3: 892-895. PMID 22737401 DOI: 10.1039/C2Sc00866A  0.37
2012 Kim D, Nah JH, Choi SS, Shin HS, Sherman DH, Kim ES. Biological activities of an engineered tautomycetin analogue via disruption of tmcR-encoding hydroxylase in Streptomyces sp. CK4412. Journal of Industrial Microbiology & Biotechnology. 39: 1563-8. PMID 22733296 DOI: 10.1007/S10295-012-1157-2  0.406
2012 Bolduc KL, Larsen SD, Sherman DH. Efficient, divergent synthesis of cryptophycin unit A analogues. Chemical Communications (Cambridge, England). PMID 22617820 DOI: 10.1039/C2Cc32417B  0.319
2012 Finefield JM, Sherman DH, Kreitman M, Williams RM. Enantiomeric natural products: occurrence and biogenesis. Angewandte Chemie (International Ed. in English). 51: 4802-36. PMID 22555867 DOI: 10.1002/Anie.201107204  0.326
2012 Anzai Y, Tsukada S, Sakai A, Masuda R, Harada C, Domeki A, Li S, Kinoshita K, Sherman DH, Kato F. Function of cytochrome P450 enzymes MycCI and MycG in Micromonospora griseorubida, a producer of the macrolide antibiotic mycinamicin. Antimicrobial Agents and Chemotherapy. 56: 3648-56. PMID 22547618 DOI: 10.1128/Aac.06063-11  0.639
2012 Finefield JM, Frisvad JC, Sherman DH, Williams RM. Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indole alkaloids. Journal of Natural Products. 75: 812-33. PMID 22502590 DOI: 10.1021/Np200954V  0.399
2012 Chemler JA, Buchholz TJ, Geders TW, Akey DL, Rath CM, Chlipala GE, Smith JL, Sherman DH. Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor. Journal of the American Chemical Society. 134: 7359-66. PMID 22480290 DOI: 10.1021/Ja2112228  0.814
2012 Nusca TD, Kim Y, Maltseva N, Lee JY, Eschenfeldt W, Stols L, Schofield MM, Scaglione JB, Dixon SD, Oves-Costales D, Challis GL, Hanna PC, Pfleger BF, Joachimiak A, Sherman DH. Functional and structural analysis of the siderophore synthetase AsbB through reconstitution of the petrobactin biosynthetic pathway from Bacillus anthracis. The Journal of Biological Chemistry. 287: 16058-72. PMID 22408253 DOI: 10.1074/Jbc.M112.359349  0.832
2012 Lee MJ, Kong D, Han K, Sherman DH, Bai L, Deng Z, Lin S, Kim ES. Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica. Applied Microbiology and Biotechnology. 95: 157-68. PMID 22382166 DOI: 10.1007/S00253-012-3955-X  0.441
2012 Li S, Finefield JM, Sunderhaus JD, McAfoos TJ, Williams RM, Sherman DH. Biochemical characterization of NotB as an FAD-dependent oxidase in the biosynthesis of notoamide indole alkaloids. Journal of the American Chemical Society. 134: 788-91. PMID 22188465 DOI: 10.1021/Ja2093212  0.651
2012 Gehret JJ, Gu L, Geders TW, Brown WC, Gerwick L, Gerwick WH, Sherman DH, Smith JL. Structure and activity of DmmA, a marine haloalkane dehalogenase. Protein Science : a Publication of the Protein Society. 21: 239-48. PMID 22124946 DOI: 10.1002/Pro.2009  0.575
2012 Busche A, Gottstein D, Hein C, Ripin N, Pader I, Tufar P, Eisman EB, Gu L, Walsh CT, Sherman DH, Löhr F, Güntert P, Dötsch V. Characterization of molecular interactions between ACP and halogenase domains in the Curacin A polyketide synthase. Acs Chemical Biology. 7: 378-86. PMID 22103656 DOI: 10.1021/Cb200352Q  0.682
2012 Li S, Finefield JM, Sunderhaus JD, McAfoos TJ, Williams RM, Sherman DH. Correction to “Biochemical Characterization of NotB as an FAD-Dependent Oxidase in the Biosynthesis of Notoamide Indole Alkaloids” Journal of the American Chemical Society. 134: 20565-20565. DOI: 10.1021/Ja3107753  0.604
2012 Nah JH, Choi SS, Kim D, Shin HS, Sherman DH, Kim ES. Biosynthesis of an engineered tautomycetin analogue via disruption of tmcK-encoding terminal decarboxylase in Streptomyces CK4412 Process Biochemistry. 47: 1773-1778. DOI: 10.1016/J.Procbio.2012.05.022  0.428
2012 Buchholz TJ, Kittendorf JD, Sherman DH. Modular Polyketide Synthases Natural Products in Chemical Biology. 163-187. DOI: 10.1002/9781118391815.ch7  0.755
2011 Finefield JM, Greshock TJ, Sherman DH, Tsukamoto S, Williams RM. Notoamide E: Biosynthetic incorporation into notoamides C and D in cultures of Aspergillus versicolor NRRL 35600. Tetrahedron Letters. 52: 1987-1989. PMID 22140279 DOI: 10.1016/J.Tetlet.2011.02.078  0.315
2011 Cruz PG, Auld DS, Schultz PJ, Lovell S, Battaile KP, MacArthur R, Shen M, Tamayo-Castillo G, Inglese J, Sherman DH. Titration-based screening for evaluation of natural product extracts: identification of an aspulvinone family of luciferase inhibitors. Chemistry & Biology. 18: 1442-52. PMID 22118678 DOI: 10.1016/J.Chembiol.2011.08.011  0.327
2011 Bonnett SA, Rath CM, Shareef AR, Joels JR, Chemler JA, Håkansson K, Reynolds K, Sherman DH. Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS. Chemistry & Biology. 18: 1075-81. PMID 21944746 DOI: 10.1016/J.Chembiol.2011.07.016  0.803
2011 Akey DL, Li S, Konwerski JR, Confer LA, Bernard SM, Anzai Y, Kato F, Sherman DH, Smith JL. A new structural form in the SAM/metal-dependent o‑methyltransferase family: MycE from the mycinamicin biosynthetic pathway. Journal of Molecular Biology. 413: 438-50. PMID 21884704 DOI: 10.1016/J.Jmb.2011.08.040  0.651
2011 Rath CM, Janto B, Earl J, Ahmed A, Hu FZ, Hiller L, Dahlgren M, Kreft R, Yu F, Wolff JJ, Kweon HK, Christiansen MA, Håkansson K, Williams RM, Ehrlich GD, ... Sherman DH, et al. Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. Acs Chemical Biology. 6: 1244-56. PMID 21875091 DOI: 10.1021/Cb200244T  0.819
2011 Fribley AM, Cruz PG, Miller JR, Callaghan MU, Cai P, Narula N, Neubig RR, Showalter HD, Larsen SD, Kirchhoff PD, Larsen MJ, Burr DA, Schultz PJ, Jacobs RR, Tamayo-Castillo G, ... ... Sherman DH, et al. Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response. Journal of Biomolecular Screening. 16: 825-35. PMID 21844328 DOI: 10.1177/1087057111414893  0.575
2011 Ding Y, Rath CM, Bolduc KL, Håkansson K, Sherman DH. Chemoenzymatic synthesis of cryptophycin anticancer agents by an ester bond-forming non-ribosomal peptide synthetase module. Journal of the American Chemical Society. 133: 14492-5. PMID 21823639 DOI: 10.1021/Ja204716F  0.82
2011 Sunderhaus JD, Sherman DH, Williams RM. Studies on the Biosynthesis of the Stephacidin and Notoamide Natural Products: A Stereochemical and Genetic Conundrum. Israel Journal of Chemistry. 51: 442-452. PMID 21818159 DOI: 10.1002/Ijch.201100016  0.436
2011 Carlson JC, Li S, Gunatilleke SS, Anzai Y, Burr DA, Podust LM, Sherman DH. Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes. Nature Chemistry. 3: 628-33. PMID 21778983 DOI: 10.1038/Nchem.1087  0.749
2011 Finefield JM, Kato H, Greshock TJ, Sherman DH, Tsukamoto S, Williams RM. Biosynthetic studies of the notoamides: isotopic synthesis of stephacidin A and incorporation into notoamide B and sclerotiamide. Organic Letters. 13: 3802-5. PMID 21714564 DOI: 10.1021/Ol201284Y  0.328
2011 Singh S, Chang A, Goff RD, Bingman CA, Grüschow S, Sherman DH, Phillips GN, Thorson JS. Structural characterization of the mitomycin 7-O-methyltransferase. Proteins. 79: 2181-8. PMID 21538548 DOI: 10.1002/Prot.23040  0.346
2011 Finefield JM, Sherman DH, Tsukamoto S, Williams RM. Studies on the biosynthesis of the notoamides: synthesis of an isotopomer of 6-hydroxydeoxybrevianamide E and biosynthetic incorporation into notoamide J. The Journal of Organic Chemistry. 76: 5954-8. PMID 21504234 DOI: 10.1021/Jo200218A  0.37
2011 Gu L, Eisman EB, Dutta S, Franzmann TM, Walter S, Gerwick WH, Skiniotis G, Sherman DH. Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect. Angewandte Chemie (International Ed. in English). 50: 2795-8. PMID 21387490 DOI: 10.1002/Anie.201005280  0.548
2011 Gehret JJ, Gu L, Gerwick WH, Wipf P, Sherman DH, Smith JL. Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase. The Journal of Biological Chemistry. 286: 14445-54. PMID 21357626 DOI: 10.1074/Jbc.M110.214635  0.622
2010 McAfoos TJ, Li S, Tsukamoto S, Sherman DH, Williams RM. STUDIES ON THE BIOSYNTHESIS OF THE STEPHACIDINS AND NOTOAMIDES. TOTAL SYNTHESIS OF NOTOAMIDE S. Heterocycles. 82: 461-472. PMID 21796227 DOI: 10.3987/Com-10-S(E)19  0.62
2010 Buchholz TJ, Rath CM, Lopanik NB, Gardner NP, Håkansson K, Sherman DH. Polyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthase. Chemistry & Biology. 17: 1092-100. PMID 21035732 DOI: 10.1016/J.Chembiol.2010.08.008  0.813
2010 Himpsl SD, Pearson MM, Arewång CJ, Nusca TD, Sherman DH, Mobley HL. Proteobactin and a yersiniabactin-related siderophore mediate iron acquisition in Proteus mirabilis. Molecular Microbiology. 78: 138-57. PMID 20923418 DOI: 10.1111/J.1365-2958.2010.07317.X  0.786
2010 Mortison JD, Sherman DH. Frontiers and opportunities in chemoenzymatic synthesis. The Journal of Organic Chemistry. 75: 7041-51. PMID 20882949 DOI: 10.1021/Jo101124N  0.813
2010 Ding Y, de Wet JR, Cavalcoli J, Li S, Greshock TJ, Miller KA, Finefield JM, Sunderhaus JD, McAfoos TJ, Tsukamoto S, Williams RM, Sherman DH. Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived Aspergillus sp. Journal of the American Chemical Society. 132: 12733-40. PMID 20722388 DOI: 10.1021/Ja1049302  0.738
2010 Khare D, Wang B, Gu L, Razelun J, Sherman DH, Gerwick WH, HÃ¥kansson K, Smith JL. Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 14099-104. PMID 20660778 DOI: 10.1073/Pnas.1006738107  0.754
2010 Scaglione JB, Akey DL, Sullivan R, Kittendorf JD, Rath CM, Kim ES, Smith JL, Sherman DH. Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase. Angewandte Chemie (International Ed. in English). 49: 5726-30. PMID 20623733 DOI: 10.1002/Anie.201000032  0.736
2010 Carlson PE, Dixon SD, Janes BK, Carr KA, Nusca TD, Anderson EC, Keene SE, Sherman DH, Hanna PC. Genetic analysis of petrobactin transport in Bacillus anthracis. Molecular Microbiology. 75: 900-9. PMID 20487286 DOI: 10.1111/J.1365-2958.2009.07025.X  0.78
2010 Jones AC, Monroe EA, Eisman EB, Gerwick L, Sherman DH, Gerwick WH. The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria. Natural Product Reports. 27: 1048-65. PMID 20442916 DOI: 10.1039/C000535E  0.401
2010 Tsukada S, Anzai Y, Li S, Kinoshita K, Sherman DH, Kato F. Gene targeting for O-methyltransferase genes, mycE and mycF, on the chromosome of Micromonospora griseorubida producing mycinamicin with a disruption cassette containing the bacteriophage phi C31 attB attachment site. Fems Microbiology Letters. 304: 148-56. PMID 20158522 DOI: 10.1111/J.1574-6968.2010.01899.X  0.624
2010 Akey DL, Razelun JR, Tehranisa J, Sherman DH, Gerwick WH, Smith JL. Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway. Structure (London, England : 1993). 18: 94-105. PMID 20152156 DOI: 10.1016/J.Str.2009.10.018  0.42
2010 Carlson JC, Fortman JL, Anzai Y, Li S, Burr DA, Sherman DH. Identification of the tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9. Chembiochem : a European Journal of Chemical Biology. 11: 564-72. PMID 20127927 DOI: 10.1002/Cbic.200900658  0.811
2010 Ding Y, Sherman DH. The role of synthesis and biosynthetic logic Comprehensive Natural Products Ii: Chemistry and Biology. 2: 559-579.  0.438
2010 Rath CM, Scaglione JB, Kittendorf JD, Sherman DH. NRPS/PKS hybrid enzymes and their natural products Comprehensive Natural Products Ii: Chemistry and Biology. 1: 453-492.  0.729
2009 Carlson JC, Li S, Burr DA, Sherman DH. Isolation and characterization of tirandamycins from a marine-derived Streptomyces sp. Journal of Natural Products. 72: 2076-9. PMID 19883065 DOI: 10.1021/Np9005597  0.709
2009 Sherman DH. Biochemistry: Enzyme's black box cracked open. Nature. 461: 1068-9. PMID 19847256 DOI: 10.1038/4611068A  0.325
2009 Gu L, Wang B, Kulkarni A, Gehret JJ, Lloyd KR, Gerwick L, Gerwick WH, Wipf P, HÃ¥kansson K, Smith JL, Sherman DH. Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. Journal of the American Chemical Society. 131: 16033-5. PMID 19835378 DOI: 10.1021/Ja9071578  0.745
2009 Li S, Chaulagain MR, Knauff AR, Podust LM, Montgomery J, Sherman DH. Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase. Proceedings of the National Academy of Sciences of the United States of America. 106: 18463-8. PMID 19833867 DOI: 10.1073/Pnas.0907203106  0.652
2009 Mortison JD, Kittendorf JD, Sherman DH. Synthesis and biochemical analysis of complex chain-elongation intermediates for interrogation of molecular specificity in the erythromycin and pikromycin polyketide synthases. Journal of the American Chemical Society. 131: 15784-93. PMID 19810731 DOI: 10.1021/Ja9060596  0.828
2009 Kim BG, Lee MJ, Seo J, Hwang YB, Lee MY, Han K, Sherman DH, Kim ES. Identification of functionally clustered nystatin-like biosynthetic genes in a rare actinomycetes, Pseudonocardia autotrophica. Journal of Industrial Microbiology & Biotechnology. 36: 1425-34. PMID 19697072 DOI: 10.1007/S10295-009-0629-5  0.388
2009 Li MH, Ung PM, Zajkowski J, Garneau-Tsodikova S, Sherman DH. Automated genome mining for natural products. Bmc Bioinformatics. 10: 185. PMID 19531248 DOI: 10.1186/1471-2105-10-185  0.381
2009 Gu L, Wang B, Kulkarni A, Geders TW, Grindberg RV, Gerwick L, HÃ¥kansson K, Wipf P, Smith JL, Gerwick WH, Sherman DH. Metamorphic enzyme assembly in polyketide diversification. Nature. 459: 731-5. PMID 19494914 DOI: 10.1038/Nature07870  0.735
2009 Yan J, Gupta S, Sherman DH, Reynolds KA. Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules by using a matched pair of heterologous docking domains. Chembiochem : a European Journal of Chemical Biology. 10: 1537-43. PMID 19437523 DOI: 10.1002/Cbic.200900098  0.373
2009 Hu PJ, Sherman DH. DANSing with Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 106: 7685-6. PMID 19416852 DOI: 10.1073/Pnas.0903021106  0.322
2009 Li S, Anzai Y, Kinoshita K, Kato F, Sherman DH. Functional analysis of MycE and MycF, two O-methyltransferases involved in the biosynthesis of mycinamicin macrolide antibiotics. Chembiochem : a European Journal of Chemical Biology. 10: 1297-301. PMID 19415708 DOI: 10.1002/Cbic.200900088  0.602
2009 Park SH, Choi SS, Kim YJ, Chang YK, Sherman DH, Kim ES. Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412. Journal of Industrial Microbiology & Biotechnology. 36: 993-8. PMID 19408025 DOI: 10.1007/S10295-009-0580-5  0.357
2009 Jones AC, Gu L, Sorrels CM, Sherman DH, Gerwick WH. New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria. Current Opinion in Chemical Biology. 13: 216-23. PMID 19307147 DOI: 10.1016/J.Cbpa.2009.02.019  0.626
2009 Sharp K, Arthur KE, Gu L, Ross C, Harrison G, Gunasekera SP, Meickle T, Matthew S, Luesch H, Thacker RW, Sherman DH, Paul VJ. Phylogenetic and chemical diversity of three chemotypes of bloom-forming lyngbya species (Cyanobacteria: Oscillatoriales) from reefs of southeastern Florida. Applied and Environmental Microbiology. 75: 2879-88. PMID 19270119 DOI: 10.1128/Aem.02656-08  0.563
2009 Chamberland S, Grüschow S, Sherman DH, Williams RM. Synthesis of potential early-stage intermediates in the biosynthesis of FR900482 and mitomycin C. Organic Letters. 11: 791-4. PMID 19161340 DOI: 10.1021/Ol802631C  0.337
2009 Buchholz TJ, Geders TW, Bartley FE, Reynolds KA, Smith JL, Sherman DH. Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains. Acs Chemical Biology. 4: 41-52. PMID 19146481 DOI: 10.1021/Cb8002607  0.777
2009 Li S, Ouellet H, Sherman DH, Podust LM. Analysis of transient and catalytic desosamine-binding pockets in cytochrome P-450 PikC from Streptomyces venezuelae. The Journal of Biological Chemistry. 284: 5723-30. PMID 19124459 DOI: 10.1074/Jbc.M807592200  0.625
2009 Kittendorf JD, Sherman DH. The methymycin/pikromycin pathway: a model for metabolic diversity in natural product biosynthesis. Bioorganic & Medicinal Chemistry. 17: 2137-46. PMID 19027305 DOI: 10.1016/J.Bmc.2008.10.082  0.442
2009 Gu L, Wang B, Sherman D, Håkansson K. IRMPD-based quantification of ER-catalyzed saturation and cyclopropanation reactions Nature Protocols. DOI: 10.1038/Nprot.2009.131  0.685
2009 Park SH, Choi SS, Sherman DH, Kim ES. A global positive regulator afsR2 stimulates tautomycetin production via pathway-specific regulatory gene over-expression in Streptomyces sp. CK4412 Process Biochemistry. 44: 1298-1301. DOI: 10.1016/J.Procbio.2009.08.005  0.341
2008 Lopanik NB, Shields JA, Buchholz TJ, Rath CM, Hothersall J, Haygood MG, Håkansson K, Thomas CM, Sherman DH. In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont. Chemistry & Biology. 15: 1175-86. PMID 19022178 DOI: 10.1016/J.Chembiol.2008.09.013  0.814
2008 Pfleger BF, Kim Y, Nusca TD, Maltseva N, Lee JY, Rath CM, Scaglione JB, Janes BK, Anderson EC, Bergman NH, Hanna PC, Joachimiak A, Sherman DH. Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 17133-8. PMID 18955706 DOI: 10.1073/Pnas.0808118105  0.806
2008 Ding Y, Greshock TJ, Miller KA, Sherman DH, Williams RM. Premalbrancheamide: synthesis, isotopic labeling, biosynthetic incorporation, and detection in cultures of Malbranchea aurantiaca. Organic Letters. 10: 4863-6. PMID 18844365 DOI: 10.1021/Ol8019633  0.511
2008 Hur YA, Choi SS, Sherman DH, Kim ES. Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412. Microbiology (Reading, England). 154: 2912-9. PMID 18832298 DOI: 10.1099/Mic.0.2008/018903-0  0.401
2008 Anzai Y, Li S, Chaulagain MR, Kinoshita K, Kato F, Montgomery J, Sherman DH. Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics. Chemistry & Biology. 15: 950-9. PMID 18804032 DOI: 10.1016/J.Chembiol.2008.07.014  0.663
2008 Smith JL, Sherman DH. Biochemistry. An enzyme assembly line. Science (New York, N.Y.). 321: 1304-5. PMID 18772425 DOI: 10.1126/Science.1163785  0.316
2008 Ding Y, Gruschow S, Greshock TJ, Finefield JM, Sherman DH, Williams RM. Detection of VM55599 and preparaherquamide from Aspergillus japonicus and Penicillium fellutanum: biosynthetic implications. Journal of Natural Products. 71: 1574-8. PMID 18754595 DOI: 10.1021/Np800292N  0.496
2008 Jayapal KP, Philp RJ, Kok YJ, Yap MG, Sherman DH, Griffin TJ, Hu WS. Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. Plos One. 3: e2097. PMID 18461186 DOI: 10.1371/Journal.Pone.0002097  0.333
2008 Ding Y, Williams RM, Sherman DH. Molecular analysis of a 4-dimethylallyltryptophan synthase from Malbranchea aurantiaca. The Journal of Biological Chemistry. 283: 16068-76. PMID 18390548 DOI: 10.1074/Jbc.M801991200  0.622
2008 Ding Y, Seufert WH, Beck ZQ, Sherman DH. Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity. Journal of the American Chemical Society. 130: 5492-8. PMID 18366166 DOI: 10.1021/Ja710520Q  0.588
2008 Miller KA, Welch TR, Greshock TJ, Ding Y, Sherman DH, Williams RM. Biomimetic total synthesis of malbrancheamide and malbrancheamide B. The Journal of Organic Chemistry. 73: 3116-9. PMID 18345688 DOI: 10.1021/Jo800116Y  0.524
2008 Lian W, Jayapal KP, Charaniya S, Mehra S, Glod F, Kyung YS, Sherman DH, Hu WS. Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2). Bmc Genomics. 9: 56. PMID 18230178 DOI: 10.1186/1471-2164-9-56  0.791
2008 Miller KA, Welch TR, Greshock TJ, Ding Y, Sherman DH, Williams RM. ChemInform Abstract: Biomimetic Total Synthesis of Malbrancheamide (IVa) and Malbrancheamide B (IVb). Cheminform. 39. DOI: 10.1002/chin.200835187  0.419
2007 Gu L, Geders TW, Wang B, Gerwick WH, Håkansson K, Smith JL, Sherman DH. GNAT-like strategy for polyketide chain initiation. Science (New York, N.Y.). 318: 970-4. PMID 17991863 DOI: 10.1126/Science.1148790  0.718
2007 Seufert W, Beck ZQ, Sherman DH. Enzymatic release and macrolactonization of cryptophycins from a safety-catch solid support. Angewandte Chemie (International Ed. in English). 46: 9298-300. PMID 17979172 DOI: 10.1002/Anie.200703665  0.375
2007 Geders TW, Gu L, Mowers JC, Liu H, Gerwick WH, Håkansson K, Sherman DH, Smith JL. Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching. The Journal of Biological Chemistry. 282: 35954-63. PMID 17928301 DOI: 10.1074/Jbc.M703921200  0.756
2007 Li S, Podust LM, Sherman DH. Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain. Journal of the American Chemical Society. 129: 12940-1. PMID 17915876 DOI: 10.1021/Ja075842D  0.609
2007 Kittendorf JD, Beck BJ, Buchholz TJ, Seufert W, Sherman DH. Interrogating the molecular basis for multiple macrolactone ring formation by the pikromycin polyketide synthase. Chemistry & Biology. 14: 944-54. PMID 17719493 DOI: 10.1016/J.Chembiol.2007.07.013  0.776
2007 Jayapal KP, Lian W, Glod F, Sherman DH, Hu WS. Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans. Bmc Genomics. 8: 229. PMID 17623098 DOI: 10.1186/1471-2164-8-229  0.545
2007 Beck ZQ, Burr DA, Sherman DH. Characterization of the beta-methylaspartate-alpha-decarboxylase (CrpG) from the cryptophycin biosynthetic pathway. Chembiochem : a European Journal of Chemical Biology. 8: 1373-5. PMID 17600793 DOI: 10.1002/Cbic.200700162  0.513
2007 Kwon SJ, Lee MY, Ku B, Sherman DH, Dordick JS. High-throughput, microarray-based synthesis of natural product analogues via in vitro metabolic pathway construction. Acs Chemical Biology. 2: 419-25. PMID 17530734 DOI: 10.1021/Cb700033S  0.452
2007 Sitachitta N, Lopanik NB, Mao Y, Sherman DH. Analysis of a parallel branch in the mitomycin biosynthetic pathway involving the mitN-encoded aziridine N-methyltransferase. The Journal of Biological Chemistry. 282: 20941-7. PMID 17507379 DOI: 10.1074/Jbc.M702456200  0.583
2007 Grüschow S, Chang LC, Mao Y, Sherman DH. Hydroxyquinone O-methylation in mitomycin biosynthesis. Journal of the American Chemical Society. 129: 6470-6. PMID 17461583 DOI: 10.1021/Ja0700193  0.538
2007 Grüschow S, Buchholz TJ, Seufert W, Dordick JS, Sherman DH. Substrate profile analysis and ACP-mediated acyl transfer in Streptomyces coelicolor Type III polyketide synthases. Chembiochem : a European Journal of Chemical Biology. 8: 863-8. PMID 17440908 DOI: 10.1002/Cbic.200700026  0.793
2007 Passalacqua KD, Bergman NH, Lee JY, Sherman DH, Hanna PC. The global transcriptional responses of Bacillus anthracis Sterne (34F2) and a Delta sodA1 mutant to paraquat reveal metal ion homeostasis imbalances during endogenous superoxide stress. Journal of Bacteriology. 189: 3996-4013. PMID 17384197 DOI: 10.1128/Jb.00185-07  0.31
2007 Choi SS, Hur YA, Sherman DH, Kim ES. Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412. Microbiology (Reading, England). 153: 1095-102. PMID 17379718 DOI: 10.1099/Mic.0.2006/003194-0  0.418
2007 Pfleger BF, Lee JY, Somu RV, Aldrich CC, Hanna PC, Sherman DH. Characterization and analysis of early enzymes for petrobactin biosynthesis in Bacillus anthracis. Biochemistry. 46: 4147-57. PMID 17346033 DOI: 10.1021/Bi6023995  0.62
2007 Li S, Grüschow S, Dordick JS, Sherman DH. Molecular analysis of the role of tyrosine 224 in the active site of Streptomyces coelicolor RppA, a bacterial type III polyketide synthase. The Journal of Biological Chemistry. 282: 12765-72. PMID 17331946 DOI: 10.1074/Jbc.M700393200  0.66
2007 Liu H, Håkansson K, Lee JY, Sherman DH. Collision-activated dissociation, infrared multiphoton dissociation, and electron capture dissociation of the Bacillus anthracis siderophore petrobactin and its metal ion complexes. Journal of the American Society For Mass Spectrometry. 18: 842-9. PMID 17331739 DOI: 10.1016/J.Jasms.2007.01.005  0.596
2007 Sudek S, Lopanik NB, Waggoner LE, Hildebrand M, Anderson C, Liu H, Patel A, Sherman DH, Haygood MG. Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina. Journal of Natural Products. 70: 67-74. PMID 17253852 DOI: 10.1021/Np060361D  0.365
2007 Lee JY, Janes BK, Passalacqua KD, Pfleger BF, Bergman NH, Liu H, Håkansson K, Somu RV, Aldrich CC, Cendrowski S, Hanna PC, Sherman DH. Biosynthetic analysis of the petrobactin siderophore pathway from Bacillus anthracis. Journal of Bacteriology. 189: 1698-710. PMID 17189355 DOI: 10.1128/Jb.01526-06  0.714
2007 Oh HS, Yun JS, Nah KH, Kang HY, Sherman DH. Synthesis of the tetraketide lactones from the pikromycin biosynthetic pathway European Journal of Organic Chemistry. 3369-3379. DOI: 10.1002/Ejoc.200700254  0.314
2006 Magarvey NA, Beck ZQ, Golakoti T, Ding Y, Huber U, Hemscheidt TK, Abelson D, Moore RE, Sherman DH. Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts. Acs Chemical Biology. 1: 766-79. PMID 17240975 DOI: 10.1021/Cb6004307  0.772
2006 Venkatraman L, Salomon CE, Sherman DH, Fecik RA. Total synthesis of narbonolide and biotransformation to pikromycin. The Journal of Organic Chemistry. 71: 9853-6. PMID 17168607 DOI: 10.1021/Jo062047U  0.348
2006 Sherman DH, Smith JL. Clearing the skies over modular polyketide synthases. Acs Chemical Biology. 1: 505-9. PMID 17168537 DOI: 10.1021/Cb600376R  0.402
2006 Kittendorf JD, Sherman DH. Developing tools for engineering hybrid polyketide synthetic pathways. Current Opinion in Biotechnology. 17: 597-605. PMID 17046237 DOI: 10.1016/J.Copbio.2006.09.005  0.406
2006 Giraldes JW, Akey DL, Kittendorf JD, Sherman DH, Smith JL, Fecik RA. Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels. Nature Chemical Biology. 2: 531-6. PMID 16969373 DOI: 10.1038/Nchembio822  0.443
2006 Akey DL, Kittendorf JD, Giraldes JW, Fecik RA, Sherman DH, Smith JL. Structural basis for macrolactonization by the pikromycin thioesterase. Nature Chemical Biology. 2: 537-42. PMID 16969372 DOI: 10.1038/Nchembio824  0.416
2006 Ku B, Cha J, Srinivasan A, Kwon SJ, Jeong JC, Sherman DH, Dordick JS. Chip-based polyketide biosynthesis and functionalization. Biotechnology Progress. 22: 1102-7. PMID 16889386 DOI: 10.1021/Bp050413+  0.423
2006 Gu L, Jia J, Liu H, Håkansson K, Gerwick WH, Sherman DH. Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair. Journal of the American Chemical Society. 128: 9014-5. PMID 16834357 DOI: 10.1021/Ja0626382  0.755
2006 Sherman DH, Li S, Yermalitskaya LV, Kim Y, Smith JA, Waterman MR, Podust LM. The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae. The Journal of Biological Chemistry. 281: 26289-97. PMID 16825192 DOI: 10.1074/Jbc.M605478200  0.667
2006 Flatt PM, O'Connell SJ, McPhail KL, Zeller G, Willis CL, Sherman DH, Gerwick WH. Characterization of the initial enzymatic steps of barbamide biosynthesis. Journal of Natural Products. 69: 938-44. PMID 16792414 DOI: 10.1021/Np050523Q  0.412
2006 Lee SK, Park JW, Kim JW, Jung WS, Park SR, Choi CY, Kim ES, Kim BS, Ahn JS, Sherman DH, Yoon YJ. Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae. Journal of Natural Products. 69: 847-9. PMID 16724858 DOI: 10.1021/Np060026P  0.399
2006 Jung WS, Lee SK, Hong JS, Park SR, Jeong SJ, Han AR, Sohng JK, Kim BG, Choi CY, Sherman DH, Yoon YJ. Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae. Applied Microbiology and Biotechnology. 72: 763-9. PMID 16493552 DOI: 10.1007/S00253-006-0318-5  0.378
2006 Nishizawa T, Grüschow S, Jayamaha DH, Nishizawa-Harada C, Sherman DH. Enzymatic assembly of the bis-indole core of rebeccamycin. Journal of the American Chemical Society. 128: 724-5. PMID 16417354 DOI: 10.1021/Ja056749X  0.385
2006 Mehra S, Lian W, Jayapal KP, Charaniya SP, Sherman DH, Hu WS. A framework to analyze multiple time series data: a case study with Streptomyces coelicolor. Journal of Industrial Microbiology & Biotechnology. 33: 159-72. PMID 16217633 DOI: 10.1007/S10295-005-0034-7  0.549
2005 Beck ZQ, Aldrich CC, Magarvey NA, Georg GI, Sherman DH. Chemoenzymatic synthesis of cryptophycin/arenastatin natural products. Biochemistry. 44: 13457-66. PMID 16216069 DOI: 10.1021/Bi051140U  0.786
2005 Venkatraman L, Aldrich CC, Sherman DH, Fecik RA. Formal total synthesis of the polyketide macrolactone narbonolide. The Journal of Organic Chemistry. 70: 7267-72. PMID 16122247 DOI: 10.1021/Jo050924A  0.565
2005 Aldrich CC, Venkatraman L, Sherman DH, Fecik RA. Chemoenzymatic synthesis of the polyketide macrolactone 10-deoxymethynolide. Journal of the American Chemical Society. 127: 8910-1. PMID 15969542 DOI: 10.1021/Ja0504340  0.59
2005 Aldrich CC, Beck BJ, Fecik RA, Sherman DH. Biochemical investigation of pikromycin biosynthesis employing native penta- and hexaketide chain elongation intermediates. Journal of the American Chemical Society. 127: 8441-52. PMID 15941278 DOI: 10.1021/Ja042592H  0.574
2005 Fortman JL, Sherman DH. Utilizing the power of microbial genetics to bridge the gap between the promise and the application of marine natural products. Chembiochem : a European Journal of Chemical Biology. 6: 960-78. PMID 15880675 DOI: 10.1002/Cbic.200400428  0.789
2005 Nishizawa T, Aldrich CC, Sherman DH. Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243. Journal of Bacteriology. 187: 2084-92. PMID 15743957 DOI: 10.1128/Jb.187.6.2084-2092.2005  0.594
2005 Jeong JC, Srinivasan A, Grüschow S, Bach H, Sherman DH, Dordick JS. Exploiting the reaction flexibility of a type III polyketide synthase through in vitro pathway manipulation. Journal of the American Chemical Society. 127: 64-5. PMID 15631450 DOI: 10.1021/Ja0441559  0.31
2005 Lee S, Basnet D, Hong J, Jung W, Choi C, Lee H, Sohng J, Ryu K, Kim D, Ahn J, Kim B, Oh H, Sherman D, Joon Yoon Y. Structural Diversification of Macrolactones by Substrate-Flexible Cytochrome P450 Monooxygenases Advanced Synthesis & Catalysis. 347: 1369-1378. DOI: 10.1002/Adsc.200404354  0.396
2004 Magarvey NA, Keller JM, Bernan V, Dworkin M, Sherman DH. Isolation and characterization of novel marine-derived actinomycete taxa rich in bioactive metabolites. Applied and Environmental Microbiology. 70: 7520-9. PMID 15574955 DOI: 10.1128/Aem.70.12.7520-7529.2004  0.682
2004 Hildebrand M, Waggoner LE, Liu H, Sudek S, Allen S, Anderson C, Sherman DH, Haygood M. bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina. Chemistry & Biology. 11: 1543-52. PMID 15556005 DOI: 10.1016/J.Chembiol.2004.08.018  0.37
2004 Srinivasan A, Bach H, Sherman DH, Dordick JS. Bacterial P450-catalyzed polyketide hydroxylation on a microfluidic platform. Biotechnology and Bioengineering. 88: 528-35. PMID 15459906 DOI: 10.1002/Bit.20285  0.322
2004 Chang Z, Sitachitta N, Rossi JV, Roberts MA, Flatt PM, Jia J, Sherman DH, Gerwick WH. Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 67: 1356-67. PMID 15332855 DOI: 10.1021/Np0499261  0.423
2004 Kim BS, Sherman DH, Reynolds KA. An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases. Protein Engineering, Design & Selection : Peds. 17: 277-84. PMID 15067106 DOI: 10.1093/Protein/Gzh032  0.359
2004 Salomon CE, Magarvey NA, Sherman DH. Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery. Natural Product Reports. 21: 105-21. PMID 15039838 DOI: 10.1039/B301384G  0.677
2004 Podust LM, Bach H, Kim Y, Lamb DC, Arase M, Sherman DH, Kelly SL, Waterman MR. Comparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways. Protein Science : a Publication of the Protein Society. 13: 255-68. PMID 14691240 DOI: 10.1110/Ps.03384804  0.422
2003 Beck BJ, Aldrich CC, Fecik RA, Reynolds KA, Sherman DH. Substrate recognition and channeling of monomodules from the pikromycin polyketide synthase. Journal of the American Chemical Society. 125: 12551-7. PMID 14531700 DOI: 10.1021/Ja034841S  0.585
2003 Beck BJ, Aldrich CC, Fecik RA, Reynolds KA, Sherman DH. Iterative chain elongation by a pikromycin monomodular polyketide synthase. Journal of the American Chemical Society. 125: 4682-3. PMID 12696866 DOI: 10.1021/Ja029974C  0.602
2003 Podust LM, Kim Y, Arase M, Neely BA, Beck BJ, Bach H, Sherman DH, Lamb DC, Kelly SL, Waterman MR. The 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systems. The Journal of Biological Chemistry. 278: 12214-21. PMID 12519772 DOI: 10.1074/Jbc.M212210200  0.307
2002 Cropp TA, Kim BS, Beck BJ, Yoon YJ, Sherman DH, Reynolds KA. Recent developments in the production of novel polyketides by combinatorial biosynthesis. Biotechnology & Genetic Engineering Reviews. 19: 159-72. PMID 12520877 DOI: 10.1080/02648725.2002.10648028  0.351
2002 Chang Z, Flatt P, Gerwick WH, Nguyen VA, Willis CL, Sherman DH. The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. Gene. 296: 235-47. PMID 12383521 DOI: 10.1016/S0378-1119(02)00860-0  0.341
2002 Sherman DH. New enzymes for "warheads". Nature Biotechnology. 20: 984-5. PMID 12355111 DOI: 10.1038/Nbt1002-984  0.415
2002 Kim BS, Cropp TA, Florova G, Lindsay Y, Sherman DH, Reynolds KA. An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis. Biochemistry. 41: 10827-33. PMID 12196022 DOI: 10.1021/Bi0256779  0.399
2002 Martin TW, Dauter Z, Devedjiev Y, Sheffield P, Jelen F, He M, Sherman DH, Otlewski J, Derewenda ZS, Derewenda U. Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein. Structure (London, England : 1993). 10: 933-42. PMID 12121648 DOI: 10.1016/S0969-2126(02)00778-5  0.466
2002 Beck BJ, Yoon YJ, Reynolds KA, Sherman DH. The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase. Chemistry & Biology. 9: 575-83. PMID 12031664 DOI: 10.1016/S1074-5521(02)00146-1  0.363
2002 Yoon YJ, Beck BJ, Kim BS, Kang HY, Reynolds KA, Sherman DH. Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae. Chemistry & Biology. 9: 203-14. PMID 11880035 DOI: 10.1016/S1074-5521(02)00095-9  0.445
2001 Kyung YS, Sherman DH, Hu WS. Simultaneous analysis of spatio-temporal gene expression for cephamycin biosynthesis in Streptomyces clavuligerus. Biotechnology Progress. 17: 1000-7. PMID 11735432 DOI: 10.1021/Bp0101076  0.725
2001 Zhang Q, Sherman DH. Isolation and structure determination of novamethymycin, a new bioactive metabolite of the methymycin biosynthetic pathway in Streptomyces venezuelae. Journal of Natural Products. 64: 1447-50. PMID 11720530 DOI: 10.1021/Np010146R  0.424
2001 Penketh PG, Hodnick WF, Belcourt MF, Shyam K, Sherman DH, Sartorelli AC. Inhibition of DNA cross-linking by mitomycin C by peroxidase-mediated oxidation of mitomycin C hydroquinone. The Journal of Biological Chemistry. 276: 34445-52. PMID 11457837 DOI: 10.1074/Jbc.M104263200  0.3
2001 Varoglu M, Mao Y, Sherman DH. Mapping the mitomycin biosynthetic pathway by functional analysis of the MitM aziridine N-methyltransferase. Journal of the American Chemical Society. 123: 6712-3. PMID 11439066 DOI: 10.1021/Ja015646L  0.451
2001 Kyung YS, Hu WS, Sherman DH. Analysis of temporal and spatial expression of the CcaR regulatory element in the cephamycin C biosynthetic pathway using green fluorescent protein. Molecular Microbiology. 40: 530-41. PMID 11359561 DOI: 10.1046/J.1365-2958.2001.02386.X  0.733
2001 Wilson DJ, Xue Y, Reynolds KA, Sherman DH. Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. Journal of Bacteriology. 183: 3468-75. PMID 11344155 DOI: 10.1128/Jb.183.11.3468-3475.2001  0.573
2001 Chen S, Roberts JB, Xue Y, Sherman DH, Reynolds KA. The Streptomyces venezuelae pikAV gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide. Gene. 263: 255-64. PMID 11223265 DOI: 10.1016/S0378-1119(00)00560-6  0.568
2001 Xue Y, Sherman DH. Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae. Metabolic Engineering. 3: 15-26. PMID 11162229 DOI: 10.1006/Mben.2000.0167  0.558
2001 He M, Sheldon PJ, Sherman DH. Characterization of a quinone reductase activity for the mitomycin C binding protein (MRD): Functional switching from a drug-activating enzyme to a drug-binding protein. Proceedings of the National Academy of Sciences of the United States of America. 98: 926-31. PMID 11158572 DOI: 10.1073/Pnas.98.3.926  0.494
2000 Chen S, Xue Y, Sherman DH, Reynolds KA. Mechanisms of molecular recognition in the pikromycin polyketide synthase. Chemistry & Biology. 7: 907-18. PMID 11137814 DOI: 10.1016/S1074-5521(00)00039-9  0.556
2000 Khetan A, Hu WS, Sherman DH. Heterogeneous distribution of lysine 6-aminotransferase during cephamycin C biosynthesis in Streptomyces clavuligerus demonstrated using green fluorescent protein as a reporter. Microbiology (Reading, England). 146: 1869-80. PMID 10931891 DOI: 10.1099/00221287-146-8-1869  0.303
2000 He M, Varoglu M, Sherman DH. Structural modeling and site-directed mutagenesis of the actinorhodin beta-ketoacyl-acyl carrier protein synthase. Journal of Bacteriology. 182: 2619-23. PMID 10762267 DOI: 10.1128/Jb.182.9.2619-2623.2000  0.476
2000 Xue Y, Wilson D, Sherman DH. Genetic architecture of the polyketide synthases for methymycin and pikromycin series macrolides. Gene. 245: 203-11. PMID 10713461 DOI: 10.1016/S0378-1119(00)00003-2  0.569
2000 Xue Y, Sherman DH. Alternative modular polyketide synthase expression controls macrolactone structure. Nature. 403: 571-5. PMID 10676969 DOI: 10.1038/35000624  0.599
1999 Borisova SA, Zhao L, Sherman DH, Liu HW. Biosynthesis of desosamine: construction of a new macrolide carrying a genetically designed sugar moiety. Organic Letters. 1: 133-6. PMID 10822548 DOI: 10.1021/Ol9906007  0.372
1999 Han L, Khetan A, Hu WS, Sherman DH. Time-lapsed confocal microscopy reveals temporal and spatial expression of the lysine epsilon-aminotransferase gene in Streptomyces clavuligerus. Molecular Microbiology. 34: 878-86. PMID 10594815 DOI: 10.1046/J.1365-2958.1999.01638.X  0.336
1999 Khetan A, Malmberg LH, Kyung YS, Sherman DH, Hu WS. Precursor and cofactor as a check valve for cephamycin biosynthesis in Streptomyces clavuligerus. Biotechnology Progress. 15: 1020-7. PMID 10585184 DOI: 10.1021/Bp990090F  0.742
1999 Belcourt MF, Penketh PG, Hodnick WF, Johnson DA, Sherman DH, Rockwell S, Sartorelli AC. Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA. Proceedings of the National Academy of Sciences of the United States of America. 96: 10489-94. PMID 10468636 DOI: 10.1073/Pnas.96.18.10489  0.333
1999 Sheldon PJ, Mao Y, He M, Sherman DH. Mitomycin resistance in Streptomyces lavendulae includes a novel drug-binding-protein-dependent export system. Journal of Bacteriology. 181: 2507-12. PMID 10198016 DOI: 10.1128/Jb.181.8.2507-2512.1999  0.582
1999 Mao Y, Varoglu M, Sherman DH. Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564. Chemistry & Biology. 6: 251-63. PMID 10099135 DOI: 10.1016/S1074-5521(99)80040-4  0.569
1999 Mao Y, Varoglu M, Sherman DH. Genetic localization and molecular characterization of two key genes (mitAB) required for biosynthesis of the antitumor antibiotic mitomycin C. Journal of Bacteriology. 181: 2199-208. PMID 10094699 DOI: 10.1128/Jb.181.7.2199-2208.1999  0.572
1999 Zhao L, Ahlert J, Xue Y, Thorson JS, Sherman DH, Liu HW. Engineering a methymycin/pikromycin-calicheamicin hybrid: Construction of two new macrolides carrying a designed sugar moiety [6] Journal of the American Chemical Society. 121: 9881-9882. DOI: 10.1021/Ja992810K  0.47
1998 Williams MD, Rahn JA, Smith S, Joshi AK, Sherman DH. Production of a polyhydroxyalkanoate biopolymer in insect cells with a modified eucaryotic Fatty Acid synthase. Applied and Environmental Microbiology. 64: 383. PMID 16349493 DOI: 10.1128/Aem.64.1.383-383.1998  0.391
1998 Xue Y, Wilson D, Zhao L, Liu Hw, Sherman DH. Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae. Chemistry & Biology. 5: 661-7. PMID 9831532 DOI: 10.1016/S1074-5521(98)90293-9  0.597
1998 Bedekar A, Zink RM, Sherman DH, Line TV, Van Pilsum JF. The comparative amino acid sequences, substrate specificities and gene or cDNA nucleotide sequences of some prokaryote and eukaryote amidinotransferases: implications for evolution. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 119: 677-90. PMID 9787760 DOI: 10.1016/S0305-0491(98)00043-1  0.307
1998 Xue Y, Zhao L, Liu HW, Sherman DH. A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity. Proceedings of the National Academy of Sciences of the United States of America. 95: 12111-6. PMID 9770448 DOI: 10.1073/Pnas.95.21.12111  0.587
1998 Zhao L, Que NLS, Xue Y, Sherman DH, Liu H. Mechanistic Studies of Desosamine Biosynthesis:  C-4 Deoxygenation Precedes C-3 Transamination Journal of the American Chemical Society. 120: 12159-12160. DOI: 10.1021/Ja982942Y  0.469
1998 Zhao L, Sherman DH, Liu H. Biosynthesis of Desosamine:  Construction of a New Methymycin/Neomethymycin Analogue by Deletion of a Desosamine Biosynthetic Gene Journal of the American Chemical Society. 120: 10256-10257. DOI: 10.1021/Ja981782N  0.316
1997 Sheldon PJ, Johnson DA, August PR, Liu HW, Sherman DH. Characterization of a mitomycin-binding drug resistance mechanism from the producing organism, Streptomyces lavendulae. Journal of Bacteriology. 179: 1796-804. PMID 9045843 DOI: 10.1128/Jb.179.5.1796-1804.1997  0.347
1997 Williams MD, Fieno AM, Grant RA, Sherman DH. Expression and analysis of a bacterial poly(hydroxyalkanoate) synthase in insect cells using a baculovirus system. Protein Expression and Purification. 7: 203-11. PMID 8812862 DOI: 10.1006/Prep.1996.0028  0.385
1996 August PR, Rahn JA, Flickinger MC, Sherman DH. Inducible synthesis of the mitomycin C resistance gene product (MCRA) from Streptomyces lavendulae. Gene. 175: 261-7. PMID 8917108 DOI: 10.1016/0378-1119(96)00172-2  0.396
1996 Khetan A, Malmberg LH, Sherman DH, Hu WS. Metabolic engineering of cephalosporin biosynthesis in Streptomyces clavuligerus. Annals of the New York Academy of Sciences. 782: 17-24. PMID 8659893 DOI: 10.1111/J.1749-6632.1996.Tb40543.X  0.4
1996 Malmberg LH, Hu WS, Sherman DH. Effects of enhanced lysine epsilon-aminotransferase activity on cephamycin biosynthesis in Streptomyces clavuligerus. Applied Microbiology and Biotechnology. 44: 198-205. PMID 8579831 DOI: 10.1007/Bf00164502  0.399
1995 Kim ES, Cramer KD, Shreve AL, Sherman DH. Heterologous expression of an engineered biosynthetic pathway: functional dissection of type II polyketide synthase components in Streptomyces species. Journal of Bacteriology. 177: 1202-7. PMID 7868592 DOI: 10.1128/Jb.177.5.1202-1207.1995  0.388
1995 Crosby J, Sherman DH, Bibb MJ, Revill WP, Hopwood DA, Simpson TJ. Polyketide synthase acyl carrier proteins from Streptomyces: expression in Escherichia coli, purification and partial characterisation. Biochimica Et Biophysica Acta. 1251: 32-42. PMID 7647090 DOI: 10.1016/0167-4838(95)00053-W  0.343
1994 Bibb MJ, Sherman DH, Omura S, Hopwood DA. Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin. Gene. 142: 31-9. PMID 8181754 DOI: 10.1016/0378-1119(94)90351-4  0.362
1994 Kim ES, Bibb MJ, Butler MJ, Hopwood DA, Sherman DH. Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus. Gene. 141: 141-2. PMID 8163168 DOI: 10.1016/0378-1119(94)90144-9  0.322
1994 Kim ES, Hopwood DA, Sherman DH. Analysis of type II polyketide beta-ketoacyl synthase specificity in Streptomyces coelicolor A3(2) by trans complementation of actinorhodin synthase mutants. Journal of Bacteriology. 176: 1801-4. PMID 8132481 DOI: 10.1128/Jb.176.6.1801-1804.1994  0.313
1993 Khosla C, McDaniel R, Ebert-Khosla S, Torres R, Sherman DH, Bibb MJ, Hopwood DA. Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins. Journal of Bacteriology. 175: 2197-204. PMID 8468280 DOI: 10.1128/Jb.175.8.2197-2204.1993  0.44
1993 Malmberg LH, Hu WS, Sherman DH. Precursor flux control through targeted chromosomal insertion of the lysine epsilon-aminotransferase (lat) gene in cephamycin C biosynthesis. Journal of Bacteriology. 175: 6916-24. PMID 8226634 DOI: 10.1128/Jb.175.21.6916-6924.1993  0.372
1992 Arrowsmith TJ, Malpartida F, Sherman DH, Birch A, Hopwood DA, Robinson JA. Characterisation of actI-homologous DNA encoding polyketide synthase genes from the monensin producer Streptomyces cinnamonensis. Molecular & General Genetics : Mgg. 234: 254-64. PMID 1508151 DOI: 10.1007/Bf00283846  0.326
1992 Sherman DH, Kim ES, Bibb MJ, Hopwood DA. Functional replacement of genes for individual polyketide synthase components in Streptomyces coelicolor A3(2) by heterologous genes from a different polyketide pathway. Journal of Bacteriology. 174: 6184-90. PMID 1400167 DOI: 10.1128/Jb.174.19.6184-6190.1992  0.389
1991 Hopwood DA, Sherman DH. Molecular genetics of polyketides and its comparison to fatty acid biosynthesis. Annual Review of Genetics. 24: 37-66. PMID 2088174 DOI: 10.1146/Annurev.Ge.24.120190.000345  0.308
1991 Sherman DH, Bibb MJ, Simpson TJ, Johnson D, Malpartida F, Fernandez-Moreno M, Martinez E, Hutchinson C, Hopwood DA. Molecular genetic analysis reveals a putative bifunctional polyketide cyclase/dehydrase gene from Streptomycea coelicolor and Streptomyces violoceoruber, and a cyclase/O-methyltransferase from Streptomyces glaucescens. Tetrahedron. 47: 6029-6043. DOI: 10.1016/S0040-4020(01)86494-2  0.384
1989 Sherman DH, Malpartida F, Bibb MJ, Kieser HM, Hopwood DA. Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22. The Embo Journal. 8: 2717-2725. DOI: 10.1002/J.1460-2075.1989.Tb08413.X  0.438
1984 Kranz DM, Sherman DH, Sitkovsky MV, Pasternack MS, Eisen HN. Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera. Proceedings of the National Academy of Sciences of the United States of America. 81: 573-7. PMID 6607474 DOI: 10.1073/Pnas.81.2.573  0.526
1984 Sherman DH, Kranz DM, Eisen HN. Expression of structurally diverse Qa-2-encoded molecules on the surface of cloned cytotoxic T lymphocytes. The Journal of Experimental Medicine. 160: 1421-30. PMID 6333483 DOI: 10.1084/Jem.160.5.1421  0.55
1982 Stork G, Sherman DH. Efficient de novo construction of the indanpropionic acid precursor of 11-keto steroids. An improved internal Diels-Alder sequence Journal of the American Chemical Society. 104: 3758-3759. DOI: 10.1021/Ja00377A052  0.419
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