Mortimer Poncz - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biochemistry, Molecular Biology

281 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Poncz M, Zaitsev SV, Ahn H, Kowalska MA, Bdeir K, Camire RM, Cines DB, Stepanova V. Packaging of supplemented urokinase into naked alpha-granules of -grown megakaryocytes for targeted therapeutic delivery. Biorxiv : the Preprint Server For Biology. PMID 38106191 DOI: 10.1101/2023.12.05.570278  0.445
2023 Singh A, Ghosh R, Asuru TR, Prajapat SK, Joshi G, Gaur KK, Shrimali NM, Ojha A, Vikram NK, Poncz M, Kalia M, Guchhait P. Inhibition of cellular activation induced by platelet factor 4 via the CXCR3 pathway ameliorates Japanese encephalitis and dengue viral infections. Journal of Thrombosis and Haemostasis : Jth. PMID 38029855 DOI: 10.1016/j.jtha.2023.11.015  0.316
2023 Ngo AT, Skidmore A, Oberg J, Yarovoi I, Sarkar A, Levine N, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, et al. Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury. Jci Insight. 8. PMID 37991024 DOI: 10.1172/jci.insight.171054  0.349
2023 Carpio-Cano FD, Mao G, Goldfinger LE, Wurtzel J, Guan L, Alam AM, Lee K, Poncz ME, Rao AK. Altered Platelet-Megakaryocyte Endocytosis and Trafficking of Albumin and Fibrinogen in Haplodeficiency. Medrxiv : the Preprint Server For Health Sciences. PMID 37961544 DOI: 10.1101/2023.10.23.23297335  0.435
2023 Sarkar A, Khandelwal S, Koma G, Kim H, Gruel Y, Rollin J, Passam FH, Wool GD, Arepally GM, Cines DB, Rauova L, Poncz M. Prevention of thrombocytopenia and thrombosis in HIT using deglycosylated KKO: a novel therapeutic? Blood Advances. PMID 37196641 DOI: 10.1182/bloodadvances.2023009661  0.387
2023 Lee K, Poncz M. SLFN14 ribosomopathy and platelet dysfunction. Blood. 141: 2170-2172. PMID 37140956 DOI: 10.1182/blood.2023019949  0.415
2023 Ngo ATP, Sarkar A, Yarovoi I, Levine ND, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, Gollomp K. Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury. Biorxiv : the Preprint Server For Biology. PMID 36711969 DOI: 10.1101/2023.01.09.522931  0.316
2022 Cai Z, Bdeir K, Yarovoi SV, Rauova L, Arepally GM, Khandelwal S, Rollin J, Gruel Y, Zaitsev S, Poncz M, Greene MI, Cines DB. Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia. Journal of Thrombosis and Haemostasis : Jth. PMID 36696211 DOI: 10.1016/j.jtha.2022.11.043  0.357
2022 Lee K, Ahn H, Estevez B, Poncz M. RUNX1-deficient human megakaryocytes demonstrate thrombopoietic, and platelet half-life and functional defects. Blood. PMID 36219879 DOI: 10.1182/blood.2022017561  0.436
2022 Jalagadugula G, Mao G, Goldfinger LE, Wurtzel JG, Del Carpio-Cano F, Lambert MP, Estevez B, French DL, Poncz M, Rao AK. Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in RUNX1 deficiency. Blood Advances. PMID 35839075 DOI: 10.1182/bloodadvances.2021006945  0.348
2022 Apostolidis SA, Sarkar A, Giannini HM, Goel RR, Mathew D, Suzuki A, Baxter AE, Greenplate AR, Alanio C, Abdel-Hakeem M, Oldridge DA, Giles JR, Wu JE, Chen Z, Huang YJ, ... ... Poncz M, et al. Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19. Frontiers in Immunology. 13: 834988. PMID 35309299 DOI: 10.3389/fimmu.2022.834988  0.404
2021 Zhou J, Wu Y, Rauova L, Koma G, Wang L, Poncz M, Li H, Liu T, Fong KP, Bennett JS, Kunapuli SP, Essex DW. A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice. Blood. PMID 34752599 DOI: 10.1182/blood.2021012055  0.447
2021 Khandelwal S, Barnes A, Rauova L, Sarkar A, Rux AH, Yarovoi SV, Zaitsev S, Lambris JD, Myoung SS, Johnson A, Lee GM, Duarte M, Poncz M, Arepally GM, Cines DB. Complement mediates binding and procoagulant effects of ultra-large HIT immune complexes. Blood. PMID 34189574 DOI: 10.1182/blood.2020009487  0.351
2021 Apostolidis SA, Sarkar A, Giannini HM, Goel RR, Mathew D, Suzuki A, Baxter AE, Greenplate AR, Alanio C, Abdel-Hakeem M, Oldridge DA, Giles J, Wu JE, Chen Z, Huang YJ, ... ... Poncz M, et al. Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19. Biorxiv : the Preprint Server For Biology. PMID 33972943 DOI: 10.1101/2021.05.01.442279  0.408
2020 Wang X, Fu RY, Li C, Chen CY, Firrman J, Konkle BA, Zhang J, Li L, Xiao W, Poncz M, Miao CH. Enhancing therapeutic efficacy of in vivo platelet-targeted gene therapy in hemophilia A mice. Blood Advances. 4: 5722-5734. PMID 33216891 DOI: 10.1182/bloodadvances.2020002479  0.399
2020 Oved JH, Paris AJ, Gollomp K, Dai N, Rubey K, Wang P, Spruce L, Seeholzer SH, Poncz M, Worthen GS. Neutrophils promote clearance of nuclear debris following acid-induced lung injury. Blood. PMID 32959045 DOI: 10.1182/Blood.2020005505  0.317
2020 DeHelian DJ, Gupta S, Wu J, Thorsheim CL, Estevez B, Cooper M, Litts K, Lee-Sundlov MM, Hoffmeister K, Poncz M, Ma P, Brass LF. RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival. Blood. PMID 32542378 DOI: 10.1182/Blood.2019003251  0.551
2020 Cines DB, Zaitsev S, Rauova L, Rux AH, Stepanova V, Krishnaswamy S, Sarkar A, Kowalska MA, Zhao G, Mast AE, Blumberg LJ, McCrae KR, Poncz M, Hubbard JJ, Pyzik M, et al. FcRn augments induction of tissue factor activity by IgG-containing immune complexes. Blood. PMID 32187355 DOI: 10.1182/Blood.2019001133  0.362
2020 Johnston IH, Sarkar A, Hayes VM, Koma G, Arepally GM, Chen J, Chung DW, Lopez J, Cines DB, Rauova L, Poncz M. Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contribute to thrombus propagation. Blood. PMID 32077913 DOI: 10.1182/Blood.2018881607  0.464
2020 Adair BD, Alonso JL, van Agthoven J, Hayes V, Ahn HS, Yu IS, Lin SW, Xiong JP, Poncz M, Arnaout MA. Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis. Nature Communications. 11: 398. PMID 31964886 DOI: 10.1038/S41467-019-13928-2  0.488
2019 Patel A, Clementelli CM, Jarocha D, Mosoyan G, Else C, Kintali M, Fong H, Tong J, Gordon R, Gillespie V, Keyzner A, Poncz M, Hoffman R, Iancu-Rubin C. Pre-clinical development of a cryopreservable megakaryocytic cell product capable of sustained platelet production in mice. Transfusion. 59: 3698-3713. PMID 31802511 DOI: 10.1111/Trf.15546  0.432
2019 Gollomp K, Sarkar A, Arepally G, Cines DB, Kowalska MA, Rauova L, Poncz M. Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis. Blood. 134: 10. PMID 31723995 DOI: 10.1182/Blood-2019-123132  0.303
2019 Gollomp K, Sarkar A, Harikumar S, Seeholzer SH, Arepally GM, Hudock KM, Rauova L, Kowalska MA, Poncz M. Understanding how Fc-modification transforms a pathogenic HIT-like monoclonal antibody into a novel treatment for sepsis. Blood. PMID 31722003 DOI: 10.1182/Blood.2019002329  0.38
2019 Lyde RB, Ahn HS, Vo KK, Jarocha DJ, Tkaczynski J, Treffeisen E, Sullivan SK, Camire RM, Sabatino DE, French DL, Poncz M. Infused factor VIII-expressing platelets or megakaryocytes as a novel therapeutic strategy for hemophilia A. Blood Advances. 3: 1368-1378. PMID 31036722 DOI: 10.1182/Bloodadvances.2017007914  0.531
2019 Scanlon VM, Teixeira AM, Tyagi T, Zou S, Zhang PX, Booth CJ, Kowalska MA, Bao J, Hwa J, Hayes V, Marks MS, Poncz M, Krause DS. Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot Stability. Thrombosis and Haemostasis. PMID 30861547 DOI: 10.1055/S-0039-1679908  0.53
2019 Gollomp K, Poncz M. or : pick your poison. Blood. 133: 287-288. PMID 30679234 DOI: 10.1182/Blood-2018-11-887513  0.333
2019 Estevez B, Borst S, Jarocha DJ, Sudunagunta V, Gonzalez M, Gao P, Tan K, French DL, Gadue P, Poncz M. The Inherited Platelet Disorder of RUNX1 Haploinsufficiency (Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM)) Has a Marked Deficiency of Megakaryocyte-Biased Hematopoietic Progenitor Cells: Mechanistic Studies and Drug Correction Blood. 134: 220-220. DOI: 10.1182/Blood-2019-124851  0.416
2019 Tkaczynski J, Lyde R, Ahn H, Ayombil F, Borst S, Gadue P, French DL, Sabatino D, Camire RM, Poncz M. A Novel Approach for Generating Platelet-Delivered FVIII: Role of Transient LRP1 Expression during Megakaryopoiesis Blood. 134: 1102-1102. DOI: 10.1182/Blood-2019-124788  0.566
2019 Ahn H, Tkaczynski J, Bdeir K, Stepanova V, Cines DB, Poncz M, Zaitsev S. A Novel Platelet-Targeting Fibrinolytic Strategy: Endocytosed Urokinase By Megakaryocytes Is Stored in α-Granules and Is Functional In Vivo in a Murine Model of Thrombosis Blood. 134: 3627-3627. DOI: 10.1182/Blood-2019-124501  0.578
2018 Gollomp K, Friedman DF, Poncz M. Platelets Can Soak It Up and Then Spit It Out. Arteriosclerosis, Thrombosis, and Vascular Biology. 38: 2544-2545. PMID 30354233 DOI: 10.1161/Atvbaha.118.311863  0.517
2018 Khandelwal S, Ravi J, Rauova L, Johnson A, Lee GM, Gilner JB, Gunti S, Notkins AL, Kuchibhatla M, Frank M, Poncz M, Cines DB, Arepally GM. Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway. Blood. PMID 30309891 DOI: 10.1182/Blood-2018-03-834598  0.415
2018 Gollomp K, Kim M, Johnston I, Hayes V, Welsh J, Arepally GM, Kahn M, Lambert MP, Cuker A, Cines DB, Rauova L, Kowalska MA, Poncz M. Neutrophil accumulation and NET release contribute to thrombosis in HIT. Jci Insight. 3. PMID 30232279 DOI: 10.1172/Jci.Insight.99445  0.457
2018 Rauova L, Arepally G, Poncz M, Cines DB. Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT). Autoimmunity Reviews. PMID 30103043 DOI: 10.1016/J.Autrev.2018.05.003  0.334
2018 Dai J, Madeeva D, Hayes V, Ahn HS, Tutwiler V, Arepally GM, Cines DB, Poncz M, Rauova L. Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia. Blood. PMID 29914979 DOI: 10.1182/Blood-2018-02-830737  0.554
2018 Tkaczynski E, Arulselvan A, Tkaczynski J, Avery S, Xiao L, Torok-Storb B, Abrams K, Rao NV, Johnson G, Kennedy TP, Poncz M, Lambert MP. 2-O, 3-O desulfated heparin mitigates murine chemotherapy- and radiation-induced thrombocytopenia. Blood Advances. 2: 754-761. PMID 29599195 DOI: 10.1182/Bloodadvances.2017013672  0.454
2018 Jarocha D, Vo KK, Lyde RB, Hayes V, Camire RM, Poncz M. Enhancing functional platelet release in vivo from in vitro-grown megakaryocytes using small molecule inhibitors. Blood Advances. 2: 597-606. PMID 29545255 DOI: 10.1182/Bloodadvances.2017010975  0.519
2018 Villa CH, Pan DC, Johnston IH, Greineder CF, Walsh LR, Hood ED, Cines DB, Poncz M, Siegel DL, Muzykantov VR. Biocompatible coupling of therapeutic fusion proteins to human erythrocytes. Blood Advances. 2: 165-176. PMID 29365311 DOI: 10.1182/Bloodadvances.2017011734  0.413
2018 Oved JH, Lambert MP, Kowalska MA, Poncz M, Karczewski K. Analysis of the Frequency of Spontaneous, Functionally-Significant Mutations in Genes Associated with Platelet Disorders in >120,000 Healthy Individuals Blood. 132: 2438-2438. DOI: 10.1182/Blood-2018-99-115567  0.424
2018 Jarocha DJ, Gadue P, Tong W, Newton RC, Poncz M. Janus Kinase (Jak) 1 Inhibition Affects Both Megakaryopoiesis and Thrombopoiesis Blood. 132: 2559-2559. DOI: 10.1182/Blood-2018-99-115407  0.437
2018 Lyde R, Ahn H, Hayes V, Zaistev S, Lin S, Ruggeri ZM, Li R, Muzykantov V, Cines DB, Poncz M. A Novel Anti-Glycoprotein (GP) Iba-Targeting Chimeric Fibrinolytic Agent Demonstrates In Vivo Efficacy Against Human Platelet-Enriched Thrombi in Mice Blood. 132: 990-990. DOI: 10.1182/Blood-2018-99-115262  0.436
2018 Sarkar A, Arepally G, Kowalska MA, Cines DB, Rauova L, Poncz M, Gollomp K. Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia Blood. 132: 271-271. DOI: 10.1182/Blood-2018-99-111381  0.446
2018 An HH, Poncz M, Chou ST. Induced Pluripotent Stem Cell-Derived Red Blood Cells, Megakaryocytes, and Platelets: Progress and Challenges Current Stem Cell Reports. 4: 310-317. DOI: 10.1007/S40778-018-0144-6  0.459
2017 Greineder CF, Johnston IH, Villa CH, Gollomp K, Esmon CT, Cines DB, Poncz M, Muzykantov VR. ICAM-1-targeted thrombomodulin mitigates tissue factor-driven inflammatory thrombosis in a human endothelialized microfluidic model. Blood Advances. 1: 1452-1465. PMID 29296786 DOI: 10.1182/Bloodadvances.2017007229  0.401
2017 Gollomp K, Lambert MP, Poncz M. Current status of blood 'pharming': megakaryoctye transfusions as a source of platelets. Current Opinion in Hematology. 24: 565-571. PMID 28985194 DOI: 10.1097/Moh.0000000000000378  0.51
2017 Borst S, Sim X, Poncz M, French DL, Gadue P. Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Clinical Use. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 28982668 DOI: 10.1161/Atvbaha.117.309197  0.517
2017 Hanby HA, Bao J, Noh JY, Jarocha D, Poncz M, Weiss MJ, Marks MS. Platelet dense granules begin to selectively accumulate mepacrine during proplatelet formation. Blood Advances. 1: 1478-1490. PMID 28936487 DOI: 10.1182/Bloodadvances.2017006726  0.476
2017 Rao AK, Poncz M. Defective acid hydrolase secretion in RUNX1 haplodeficiency: Evidence for a global platelet secretory defect. Haemophilia : the Official Journal of the World Federation of Hemophilia. PMID 28662545 DOI: 10.1111/Hae.13280  0.444
2017 Zhou J, Wu Y, Chen F, Wang L, Rauova L, Hayes VM, Poncz M, Li H, Liu T, Liu J, Essex DW. The disulfide isomerase ERp72 supports arterial thrombosis in mice. Blood. PMID 28576878 DOI: 10.1182/Blood-2016-12-755587  0.539
2017 Johnston I, Hayes V, Poncz M. Threading an elephant through the eye of a needle: Where are platelets made? Cell Research. PMID 28485368 DOI: 10.1038/Cr.2017.65  0.44
2017 Sim X, Jarocha D, Hayes V, Hanby HA, Marks MS, Camire RM, French DL, Poncz M, Gadue P. Identifying and enriching the platelet-producing human stem cell-derived megakaryocytes using factor V uptake. Blood. PMID 28455282 DOI: 10.1182/Blood-2017-01-761049  0.535
2017 Vo KK, Jarocha DJ, Lyde RB, Hayes V, Thom CS, Sullivan SK, French DL, Poncz M. FLI1 level during megakaryopoiesis affects thrombopoiesis and platelet biology. Blood. PMID 28432223 DOI: 10.1182/Blood-2017-02-770958  0.504
2017 Hayes V, Johnston I, Arepally GM, McKenzie SE, Cines DB, Rauova L, Poncz M. Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia. The Journal of Clinical Investigation. PMID 28218620 DOI: 10.1172/Jci90958  0.503
2016 Cines DB, Yarovoi SV, Zaitsev SV, Lebedeva T, Rauova L, Poncz M, Arepally GM, Khandelwal S, Stepanova V, Rux AH, Cuker A, Guo C, Ocariza LM, Travers RJ, Smith SA, et al. Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia. Blood Advances. 1: 62-74. PMID 29296696 DOI: 10.1182/Bloodadvances.2016000877  0.516
2016 Bdeir K, Gollomp K, Stasiak M, Mei J, Papiewska-Pajak I, Zhao G, Worthen GS, Cines DB, Poncz M, Kowalska MA. Platelet-specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury. American Journal of Respiratory Cell and Molecular Biology. PMID 27755915 DOI: 10.1165/Rcmb.2015-0245Oc  0.471
2016 Wang Q, You T, Fan H, Wang Y, Chu T, Poncz M, Zhu L. Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis. Platelets. 1-8. PMID 27534900 DOI: 10.1080/09537104.2016.1204436  0.424
2016 Madeeva D, Cines DB, Poncz M, Rauova L. Role of monocytes and endothelial cells in heparin-induced thrombocytopenia. Thrombosis and Haemostasis. 116. PMID 27487857 DOI: 10.1160/Th16-02-0162  0.5
2016 Khandelwal S, Lee GM, Hester CG, Poncz M, McKenzie S, Sachais BS, Rauova L, Kelsoe G, Cines DB, Frank M, Arepally GM. The antigenic complex in HIT binds to B-cells via complement and complement receptor 2 (CD21). Blood. PMID 27412887 DOI: 10.1182/Blood-2016-04-709634  0.382
2016 Ostertag EM, Bdeir K, Kacir S, Thiboutot M, Gulendran G, Yunk L, Hayes VM, Motto DG, Poncz M, Zheng XL, Cines DB, Siegel DL. ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model. Transfusion. PMID 27040023 DOI: 10.1111/Trf.13583  0.391
2016 Greineder CF, Hood ED, Yao A, Khoshnejad M, Brenner JS, Johnston IH, Poncz M, Gottstein C, Muzykantov VR. Molecular engineering of high affinity single-chain antibody fragment for endothelial targeting of proteins and nanocarriers in rodents and humans. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 26855052 DOI: 10.1016/J.Jconrel.2016.02.006  0.349
2016 Sim X, Poncz M, Gadue P, French DL. Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets. Blood. 127: 1227-33. PMID 26787738 DOI: 10.1182/Blood-2015-08-607929  0.543
2016 Villa CH, Pan D, Johnston I, Greineder CF, Reid ME, Cines DB, Poncz M, Siegel DL, Muzykantov VR. Coupling Therapeutics to Human Erythrocytes Demonstrates Target-Dependent Effects on Red Cell Physiology While Preserving Efficacy Blood. 128: 701-701. DOI: 10.1182/Blood.V128.22.701.701  0.369
2016 Vo KK, Jarocha DJ, Lyde RB, Sullivan SK, French D, Poncz M. Fli1 Expression Level Affects Megakaryopoiesis and Thrombopoiesis: More Is Not Always a Bad Thing Blood. 128: 3876-3876. DOI: 10.1182/Blood.V128.22.3876.3876  0.511
2016 Greineder CF, Johnston I, Villa CH, Cines DB, Poncz M, Muzykantov VR. Simultaneous Replacement of Endothelial Thrombomodulin and Plasma Protein C: A Novel Therapeutic Strategy for Sepsis-Induced Disseminated Intravascular Coagulation Blood. 128: 2613-2613. DOI: 10.1182/Blood.V128.22.2613.2613  0.41
2016 Lyde RB, Ahn H, Vo KK, Jarocha DJ, Zhai L, Sullivan SK, Arruda VR, Sabatino DE, Camire RM, French D, Poncz M. Infusion of Coagulation Factor VIII-Containing Induced Pluripotent Stem Cell (iPSC)-Derived Megakaryocytes (iMks) Shows Potential As Hemophilia a Treatment Blood. 128: 2559-2559. DOI: 10.1182/Blood.V128.22.2559.2559  0.464
2016 Johnston I, Hayes VM, Dai J, Jarocha DJ, Kubes P, Poncz M, Rauova L. Platelet Release from Infused CD34+-Derived Human Megakaryocytes: Lessons from a Natural-Occurring Platelet Bioreactor Blood. 128: 1375-1375. DOI: 10.1182/Blood.V128.22.1375.1375  0.501
2016 Jarocha DJ, Vo KK, Lyde RB, Hayes VM, Poncz M. Enhancing Functional Platelet Release In Vivo from in Vitro-Grown Megakaryocytes Using the Protein Kinase Inhibitor SU6656 Blood. 128: 1029-1029. DOI: 10.1182/Blood.V128.22.1029.1029  0.526
2016 Gollomp K, Johnston I, Rauova L, Cines DB, Kowalska MA, Poncz M. A Special Role for Neutrophil Extracellular Traps (NETs) and Neutrophils in the Prothombotic Nature of Heparin-Induced Thrombocytopenia Blood. 128: 1023-1023. DOI: 10.1182/Blood.V128.22.1023.1023  0.45
2015 Fuentes RE, Zaitsev S, Ahn HS, Hayes V, Kowalska MA, Lambert MP, Wang Y, Siegel DL, Bougie DW, Aster RH, Myers DD, Stepanova V, Cines DB, Muzykantov VR, Poncz M. A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation. The Journal of Clinical Investigation. PMID 26690701 DOI: 10.1172/Jci81470  0.818
2015 Zhang N, Zhi H, Curtis BR, Rao S, Jobaliya C, Poncz M, French DL, Newman PJ. CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes. Blood. PMID 26634302 DOI: 10.1182/Blood-2015-10-675751  0.424
2015 Zhou J, Wu Y, Wang L, Rauova L, Hayes VM, Poncz M, Essex DW. The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis. The Journal of Clinical Investigation. 2015. PMID 26529254 DOI: 10.1172/Jci80319  0.542
2015 Tutwiler V, Madeeva D, Ahn HS, Andrianova I, Hayes V, Zheng XL, Cines DB, McKenzie SE, Poncz M, Rauova L. Platelet transactivation by monocytes promotes the prothrombotic state in heparin-induced thrombocytopenia. Blood. PMID 26518435 DOI: 10.1182/Blood-2013-11-539262  0.551
2015 Cai Z, Yarovoi SV, Zhu Z, Rauova L, Hayes V, Lebedeva T, Liu Q, Poncz M, Arepally G, Cines DB, Greene MI. Atomic description of the immune complex involved in heparin-induced thrombocytopenia. Nature Communications. 6: 8277. PMID 26391892 DOI: 10.1038/Ncomms9277  0.441
2015 Lambert MP, Meng R, Xiao L, Harper DC, Marks MS, Kowalska AM, Poncz M. Intramedullary megakaryocytes internalize released platelet factor 4 (PF4) and store it in alpha granules. Journal of Thrombosis and Haemostasis : Jth. PMID 26256688 DOI: 10.1111/Jth.13069  0.429
2015 Chacko AM, Han J, Greineder CF, Zern BJ, Mikitsh JL, Nayak M, Menon D, Johnston IH, Poncz M, Eckmann DM, Davies PF, Muzykantov VR. Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement. Acs Nano. 9: 6785-93. PMID 26153796 DOI: 10.1021/Nn505672X  0.37
2015 Lyde R, Sabatino D, Sullivan SK, Poncz M. Platelet-delivered therapeutics. Journal of Thrombosis and Haemostasis : Jth. 13: S143-50. PMID 26149015 DOI: 10.1111/Jth.12938  0.488
2015 Noh JY, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan SK, Chou ST, Machlus KR, Italiano JE, Kyba M, Finkelstein D, Ulirsch JC, Sankaran VG, French DL, ... Poncz M, et al. Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. The Journal of Clinical Investigation. 125: 2369-74. PMID 25961454 DOI: 10.1172/Jci77670  0.454
2015 Joglekar M, Khandelwal S, Cines DB, Poncz M, Rauova L, Arepally GM. Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages. Journal of Thrombosis and Haemostasis : Jth. 13: 1416-27. PMID 25960020 DOI: 10.1111/Jth.13003  0.487
2015 Wang Y, Hayes V, Jarocha D, Sim X, Harper DC, Fuentes R, Sullivan SK, Gadue P, Chou ST, Torok-Storb BJ, Marks MS, French DL, Poncz M. Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale. Blood. 125: 3627-36. PMID 25852052 DOI: 10.1182/Blood-2014-08-593053  0.829
2015 Pickens B, Mao Y, Li D, Siegel DL, Poncz M, Cines DB, Zheng XL. Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models. Blood. 125: 3326-34. PMID 25800050 DOI: 10.1182/Blood-2014-07-587139  0.539
2015 Meng R, Wu J, Harper DC, Wang Y, Kowalska MA, Abrams CS, Brass LF, Poncz M, Stalker TJ, Marks MS. Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models. Blood. 125: 1623-32. PMID 25477496 DOI: 10.1182/Blood-2014-07-586727  0.416
2015 Villa CH, Greineder CF, Johnston I, Pan D, Carnemolla R, Cines DB, Poncz M, Siegel DL, Muzykantov VR. Thrombomodulin Fusion Proteins Coupled to Human Erythrocytes Demonstrate Anti-Thrombotic and Anti-Inflammatory Activity Blood. 126: 3493-3493. DOI: 10.1182/Blood.V126.23.3493.3493  0.394
2015 Greineder CF, Johnston I, Villa CH, Cines DB, Poncz M, Muzykantov VR. A Microfluidic Model of Microvascular Inflammation: Characterization and Testing of Endothelial-Targeted Therapeutics Blood. 126: 3454-3454. DOI: 10.1182/Blood.V126.23.3454.3454  0.411
2015 Vo KK, Jarocha DJ, Lyde RB, Sullivan S, French D, Poncz M. The Influence of FLI1 Expression Levels on Megakaryopoiesis: Studies Using iPSCs Blood. 126: 2352-2352. DOI: 10.1182/Blood.V126.23.2352.2352  0.319
2015 Lyde RB, Zhai L, Vo K, Jarocha DJ, Sullivan S, Arruda VR, Camire RM, French D, Poncz M. Towards the Care of Hemophilia a Patients Using Induced Pluripotent Stem Cell (iPSC)-Derived Megakaryocytes (iMks) Expressing Coagulation Factor (F) VIII Blood. 126: 2266-2266. DOI: 10.1182/Blood.V126.23.2266.2266  0.504
2015 Andrianova I, Hayes VM, Madeeva D, Litvinov RI, Cines DB, Poncz M, Weisel JW, Rauova L. Membrane Remodeling By Pathogenic Antibodies Underlies Monocyte Activation in Heparin-Induced Thrombocytopenia Blood. 126: 2244-2244. DOI: 10.1182/Blood.V126.23.2244.2244  0.482
2015 Gollomp K, Ian J, Fatoumata D, Zhao G, Krishnaswamy S, Poncz M, Kowalska MA. The NET Effect: Platelet Factor 4 and DNA-Histone Interactions in Sepsis Blood. 126: 2197-2197. DOI: 10.1182/Blood.V126.23.2197.2197  0.328
2015 Johnston I, Hayes VM, Cines DB, Poncz M. A Targeted Photochemical Microfluidic Vascular Injury Model for in Vitro Thrombosis Studies: Usage in Heparin-Induced Thrombocytopenia (HIT) Blood. 126: 212-212. DOI: 10.1182/Blood.V126.23.212.212  0.453
2015 Zhou J, Wu Y, Wang L, Rauova L, Hayes VM, Poncz M, Essex DW. The Second CGHC Motif of Protein Disulfide Isomerase Mediates Thrombosis Blood. 126: 1032-1032. DOI: 10.1182/Blood.V126.23.1032.1032  0.545
2015 Joglekar M, Khandelwal S, Cines DB, Poncz M, Rauova L, Arepally GM. Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages Journal of Thrombosis and Haemostasis. 13: 1416-1427. DOI: 10.1111/jth.13003  0.314
2014 Bruns I, Lucas D, Pinho S, Ahmed J, Lambert MP, Kunisaki Y, Scheiermann C, Schiff L, Poncz M, Bergman A, Frenette PS. Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nature Medicine. 20: 1315-20. PMID 25326802 DOI: 10.1038/Nm.3707  0.386
2014 Greene TK, Lyde RB, Bailey SC, Lambert MP, Zhai L, Sabatino DE, Camire RM, Arruda VR, Poncz M. Apoptotic effects of platelet factor VIII on megakaryopoiesis: implications for a modified human FVIII for platelet-based gene therapy. Journal of Thrombosis and Haemostasis : Jth. 12: 2102-12. PMID 25287191 DOI: 10.1111/Jth.12749  0.832
2014 Zhou J, Wu Y, Wang L, Rauova L, Hayes VM, Poncz M, Essex DW. The disulfide isomerase ERp57 is required for fibrin deposition in vivo. Journal of Thrombosis and Haemostasis : Jth. 12: 1890-7. PMID 25156521 DOI: 10.1111/Jth.12709  0.434
2014 Skewis LR, Lebedeva T, Papkov V, Thayer EC, Massefski W, Cuker A, Nagaswami C, Litvinov RI, Kowalska MA, Rauova L, Poncz M, Weisel JW, Lowery TJ, Cines DB. T2 magnetic resonance: a diagnostic platform for studying integrated hemostasis in whole blood--proof of concept. Clinical Chemistry. 60: 1174-82. PMID 24958814 DOI: 10.1373/Clinchem.2014.223735  0.386
2014 Sullivan SK, Poncz M. A(nother) day in the life of neonatal platelets. Blood. 123: 3372-3. PMID 24876525 DOI: 10.1182/Blood-2014-03-562132  0.422
2014 Noh JY, Weiss MJ, Poncz M. Personalized platelet transfusions: one step closer to the clinic. Cell Stem Cell. 14: 425-6. PMID 24702993 DOI: 10.1016/J.Stem.2014.03.012  0.44
2014 Cuker A, Rauova L, Bolgiano D, Matthai WH, Poncz M, Konkle BA. Atherosclerosis is not a risk factor for anti-platelet factor 4/heparin antibody formation after cardiopulmonary bypass surgery. Thrombosis and Haemostasis. 111: 1191-3. PMID 24477578 DOI: 10.1160/Th13-12-1012  0.394
2014 Shi G, Field DJ, Ko KA, Ture S, Srivastava K, Levy S, Kowalska MA, Poncz M, Fowell DJ, Morrell CN. Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection. The Journal of Clinical Investigation. 124: 543-52. PMID 24463452 DOI: 10.1172/Jci71858  0.404
2014 Sullivan SK, Mills JA, Koukouritaki SB, Vo KK, Lyde RB, Paluru P, Zhao G, Zhai L, Sullivan LM, Wang Y, Kishore S, Gharaibeh EZ, Lambert MP, Wilcox DA, French DL, ... Poncz M, et al. High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. Blood. 123: 753-7. PMID 24335497 DOI: 10.1182/Blood-2013-10-530725  0.449
2014 Lian L, Suzuki A, Hayes V, Saha S, Han X, Xu T, Yates JR, Poncz M, Kashina A, Abrams CS. Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation. Haematologica. 99: 554-60. PMID 24293517 DOI: 10.3324/Haematol.2013.093047  0.503
2014 Kowalska MA, Zhao G, Zhai L, David G, Marcus S, Krishnaswamy S, Poncz M. Modulation of protein C activation by histones, platelet factor 4, and heparinoids: new insights into activated protein C formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 120-6. PMID 24177324 DOI: 10.1161/Atvbaha.113.302236  0.434
2014 Kowalska MA, Zhao G, Johnston I, Treffeisen E, Diarra F, Krishnaswamy S, Poncz M. A Proposed Role for Platelet Factor 4 in Histone Pathobiology in Sepsis Blood. 124: 98-98. DOI: 10.1182/Blood.V124.21.98.98  0.366
2014 Ahn HS, Fuentes R, Hayes V, Cines DB, Muzykantov VR, Zaytsev SV, Poncz M. A Human-Specific, Platelet-Targeted, Thrombin-Activatable Urokinase (PLT/uPA-T) Demonstrates Selective Thromboprophylactic Properties in Two in Vivo Models Blood. 124: 579-579. DOI: 10.1182/Blood.V124.21.579.579  0.804
2014 Madeeva D, Tutwiler V, Cines DB, Poncz M, Rauova L. FcγRIIA Mediates the Prothrombotic Role of Monocytes in HIT Blood. 124: 575-575. DOI: 10.1182/Blood.V124.21.575.575  0.544
2014 Hayes V, Johnston I, Cines DB, Rauova L, Poncz M. New Insights into the Prothrombotic State of Heparin-Induced Thrombocytopenia (HIT) Using a Novel Microfluidic System: The Endothelial Lining and “Rolling Barrage” of Activation Blood. 124: 574-574. DOI: 10.1182/Blood.V124.21.574.574  0.527
2014 Cai Z, Yarovoi SV, Zhu Z, Rauova L, Lebedeva T, Poncz M, Arepally GM, Cines DB, Greene MI. Atomic Level Description of the Immune Complex That Causes Heparin-Induced Thrombocytopenia (HIT) Blood. 124: 465-465. DOI: 10.1182/Blood.V124.21.465.465  0.397
2014 Joglekar MV, Khandelwal S, Poncz M, Rauova L, Arepally GM. Understanding the Underlying Immune Response in HIT: Uptake of PF4/Heparin Complexes By Monocytes & Dendritic Cells Blood. 124: 4197-4197. DOI: 10.1182/Blood.V124.21.4197.4197  0.361
2014 Lambert MP, Xiao L, Poncz M. Conditional Knockout of LRP1 in Murine Megakaryocytes and Its Affects on Platelet Factor 4 Biology in Megakaryocytes Blood. 124: 4150-4150. DOI: 10.1182/Blood.V124.21.4150.4150  0.514
2014 Noh J, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan S, Chou ST, Paralkar VR, Machlus KR, Italiano JE, Kyba M, French DL, Poncz M, Weiss MJ. Inducible Gata1 Suppression As a Novel Strategy to Expand Physiologic Megakaryocyte Production from Embryonic Stem Cells Blood. 124: 3846-3846. DOI: 10.1182/Blood.V124.21.3846.3846  0.46
2014 Wang Y, Hayes V, Jarocha D, Poncz M. Comparative Analysis of Infused “Static”, Ex Vivo-Generated Platelets Vs. Infused Megakaryocytes-Generated Platelets: A Cautionary Tale Blood. 124: 2881-2881. DOI: 10.1182/Blood.V124.21.2881.2881  0.525
2014 Lambert MP, Meng R, Harper D, Xiao L, Marks MS, Poncz M. Megakaryocytes Exchange Significant Levels of Their Alpha-Granular PF4 with Their Environment Blood. 124: 1432-1432. DOI: 10.1182/Blood.V124.21.1432.1432  0.389
2013 Lambert MP, Poncz M. They're not your daddy's inherited platelet disorders anymore Journal of Thrombosis and Haemostasis. 11: 2037-2038. PMID 24103021 DOI: 10.1111/Jth.12405  0.404
2013 Siner JI, Iacobelli NP, Sabatino DE, Ivanciu L, Zhou S, Poncz M, Camire RM, Arruda VR. Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype. Blood. 121: 4396-403. PMID 23372167 DOI: 10.1182/Blood-2012-10-464164  0.365
2013 Lambert MP, Sullivan SK, Fuentes R, French DL, Poncz M. Challenges and promises for the development of donor-independent platelet transfusions. Blood. 121: 3319-24. PMID 23321255 DOI: 10.1182/Blood-2012-09-455428  0.828
2013 Zhi H, Rauova L, Hayes V, Gao C, Boylan B, Newman DK, McKenzie SE, Cooley BC, Poncz M, Newman PJ. Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood. 121: 1858-67. PMID 23264598 DOI: 10.1182/Blood-2012-07-443325  0.496
2013 Rauova L, Madeeva D, Tutwiler V, Bailey S, Hayes VM, Cines DB, Poncz M. Role Of Monocyte Fcγ Receptors In The Prothrombotic State Of Heparin Induced Thrombocytopenia (HIT) Blood. 122: 570-570. DOI: 10.1182/Blood.V122.21.570.570  0.517
2013 Rauova L, Zhang Y, Hayes VM, Nagaswami C, Cines DB, Dong J, Poncz M, Weisel JW. Imaging Morphologic Changes On Platelet and Monocyte Surfaces In Heparin-Induced Thrombocytopenia (HIT) Blood. 122: 3533-3533. DOI: 10.1182/Blood.V122.21.3533.3533  0.531
2013 Bruns I, Lucas D, Pinho S, Ahmed J, Lambert MP, Scheiermann C, Kunisaki Y, Poncz M, Frenette PS. Megakaryocytes Regulate Hematopoietic Stem Cell Quiescence Via PF4 Secretion Blood. 122: 3-3. DOI: 10.1182/Blood.V122.21.3.3  0.438
2013 Vadasz B, Chen P, Issaka Y, Zhu G, Jonathan F, Poncz M, Freedman JJ, Ni H. Novel Murine Models Of Fetal and Neonatal Alloimmune Thrombocytopenia Established In αIIb Deficient and Human αIIb Transgenic Mice Blood. 122: 2314-2314. DOI: 10.1182/Blood.V122.21.2314.2314  0.465
2013 Suzuki A, Zhao L, Wang Y, Lian L, Min SH, Poncz M, Abrams CS. Loss Of Phosphatidylinositol Transfer Proteins (PITPs) Causes Thrombocytopenia Due To a Defect In Thrombopoiesis Blood. 122: 2313-2313. DOI: 10.1182/Blood.V122.21.2313.2313  0.509
2013 Wang Y, Hayes VM, Paluru P, Chou ST, French DL, Poncz M. Insights Into Thrombopoiesis From Infused Human Megakaryocytes Into Mice Blood. 122: 1165-1165. DOI: 10.1182/Blood.V122.21.1165.1165  0.425
2013 Lambert MP, Sullivan S, Poncz M. Making Platelets Ex Vivo Platelets. 1305-1311. DOI: 10.1016/B978-0-12-387837-3.00063-8  0.414
2012 Love MS, Millholland MG, Mishra S, Kulkarni S, Freeman KB, Pan W, Kavash RW, Costanzo MJ, Jo H, Daly TM, Williams DR, Kowalska MA, Bergman LW, Poncz M, DeGrado WF, et al. Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. Cell Host & Microbe. 12: 815-23. PMID 23245326 DOI: 10.1016/J.Chom.2012.10.017  0.409
2012 Ono Y, Wang Y, Suzuki H, Okamoto S, Ikeda Y, Murata M, Poncz M, Matsubara Y. Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf. Blood. 120: 3812-21. PMID 22855609 DOI: 10.1182/Blood-2012-02-413617  0.429
2012 Meng R, Wang Y, Yao Y, Zhang Z, Harper DC, Heijnen HF, Sitaram A, Li W, Raposo G, Weiss MJ, Poncz M, Marks MS. SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models. Blood. 120: 404-14. PMID 22611153 DOI: 10.1182/Blood-2011-11-389551  0.483
2012 Sachais BS, Litvinov RI, Yarovoi SV, Rauova L, Hinds JL, Rux AH, Arepally GM, Poncz M, Cuker A, Weisel JW, Cines DB. Dynamic antibody-binding properties in the pathogenesis of HIT. Blood. 120: 1137-42. PMID 22577175 DOI: 10.1182/Blood-2012-01-407262  0.363
2012 Lambert MP, Reznikov A, Grubbs A, Nguyen Y, Xiao L, Aplenc R, Rauova L, Poncz M. Platelet factor 4 platelet levels are inversely correlated with steady-state platelet counts and with platelet transfusion needs in pediatric leukemia patients Journal of Thrombosis and Haemostasis. 10: 1442-1446. PMID 22564375 DOI: 10.1111/J.1538-7836.2012.04767.X  0.526
2012 Zaitsev S, Kowalska MA, Neyman M, Carnemolla R, Tliba S, Ding BS, Stonestrom A, Spitzer D, Atkinson JP, Poncz M, Cines DB, Esmon CT, Muzykantov VR. Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis. Blood. 119: 4779-85. PMID 22493296 DOI: 10.1182/Blood-2011-12-398149  0.471
2012 Basani RB, Richberg M, Poncz M. Molecular biological identification and characterization of inherited platelet receptor disorders. Methods in Molecular Medicine. 31: 313-36. PMID 21341008 DOI: 10.1385/1-59259-248-1:313  0.532
2012 Tutwiler V, Ahn HS, Fuentes R, Hayes VM, Zaytsev SV, Zheng XL, Cines DB, McKenzie SE, Weisel JW, Poncz M, Rauova L. Fibrin Generation in Heparin-Induced Thrombocytopenia (HIT): Pathomechanistic Background for Novel Therapy and Prophylaxis Blood. 120: 635-635. DOI: 10.1182/Blood.V120.21.635.635  0.84
2012 Lambert M, Xiao L, Meng R, Marks MS, Poncz M. Platelet Factor 4 (PF4) Is Selectively Recycled During Megakaryopoiesis Blood. 120: 388-388. DOI: 10.1182/Blood.V120.21.388.388  0.413
2012 Sullivan SK, Mills JA, Zhai L, Paluru P, Vo K, Lambert M, Koukouritaki SB, Fang J, Wilcox DA, French DL, Poncz M, Gadue P. Tissue-Specific Transgene Expression in Induced Pluripotent Stem (iPS) Cell-Derived Megakaryocytes: Correction of Glanzmann Thrombasthenia (GT) Blood. 120: 387-387. DOI: 10.1182/Blood.V120.21.387.387  0.49
2012 Lambert M, Sharma SS, Xiao L, Marcus S, Poncz M. 2-O, 3-O-Desulfated Heparin (ODSH) Mitigates Chemotherapy-Induced Thrombocytopenia (CIT) by Blocking the Negative Paracrine Effect of Platelet Factor 4 (PF4) On Megakaryopoiesis Blood. 120: 386-386. DOI: 10.1182/Blood.V120.21.386.386  0.494
2012 Suzuki A, Shin J, Wang Y, Poncz M, Choi JK, Discher DE, Carpenter CL, Lian L, Zhao L, Wang Y, Abrams CS. RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy Distribution and Platelet Generation Blood. 120: 385-385. DOI: 10.1182/Blood.V120.21.385.385  0.534
2012 Wang Y, Hayes VM, Lu L, Chen X, Fuentes R, Wen QJ, Chou ST, Crispino J, Paddison P, French DL, Torok-Storb B, Poncz M. Aryl Hydrocarbon Receptor (AhR) Antagonist Stemregenin 1 (SR1) Enhances in Vitro- and in Vivo-Derived Platelets (PLTs) From Human Megakaryocytes (MKs) Blood. 120: 3450-3450. DOI: 10.1182/Blood.V120.21.3450.3450  0.791
2012 Rauova L, Tutwiler V, Ahn HS, Hayes VM, Aster RH, Cines DB, Poncz M. The Two Phases of Heparin-Induced Thrombocytopenia (HIT): Early Monocyte/Tissue Factor (TF) Phase and Late Platelet Phase Blood. 120: 270-270. DOI: 10.1182/Blood.V120.21.270.270  0.568
2012 Siner JI, Iacobelli NP, Ivanciu L, Sabatino DE, Poncz M, Camire RM, Arruda VR. Bioengineering Factor VIII B-Domain Sequences Improves Function and Efficacy in Hemophilia A Models. Blood. 120: 2208-2208. DOI: 10.1182/Blood.V120.21.2208.2208  0.386
2012 Greene TK, Zhai L, Razzo B, Vo K, Sabatino DE, Camire RM, Arruda VR, Poncz M. Platelet Factor VIII-Induced Megakaryocyte Apoptosis: Implications for Hemophilia A Gene Therapy Blood. 120: 2051-2051. DOI: 10.1182/Blood.V120.21.2051.2051  0.831
2012 Xiao L, Poncz M, Lambert M. Platelet Factor 4 (PF4) Causes Cell Cycle Arrest in Megakaryocytes (Megs) by Inactivating CDC2 (CDK1) and CDK2 Blood. 120: 1238-1238. DOI: 10.1182/Blood.V120.21.1238.1238  0.404
2012 Fuentes R, Ahn HS, Hayes VM, Tutwiler V, Wang Y, Bougie DW, Kowalska MA, Rauova L, Aster RH, Cines DB, Muzykantov VR, Poncz M, Zaitsev S. Platelet-Targeted, Thrombin-Activatable Fibrinolytic Pro-Drugs As Novel Therapies: Application to the Prothrombotic Disorder of Heparin-Induced Thrombocytopenia (HIT) Blood. 120: 1171-1171. DOI: 10.1182/Blood.V120.21.1171.1171  0.82
2012 Cines DB, Lebedeva T, Kowalska MA, Poncz M, Rauova L, Cuker A, Weisel JW, Massefski W, Papkov V, Thayer EC, Lowery TJ. Miniaturized T2MR Magnetic Resonance System for Analysis of Hemostasis and Detection of Impaired and Prothrombotic Blood Disorders Blood. 120: 1118-1118. DOI: 10.1182/Blood.V120.21.1118.1118  0.504
2011 Greene TK, Lambert MP, Poncz M. Ectopic platelet-delivered factor (F) VIII for the treatment of Hemophilia A: Plasma and platelet FVIII, is it all the same? Journal of Genetic Syndromes & Gene Therapy. PMID 24319630 DOI: 10.4172/2157-7412.S1-001  0.817
2011 Wang Y, Meng R, Hayes V, Fuentes R, Yu X, Abrams CS, Heijnen HF, Blobel GA, Marks MS, Poncz M. Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction. Blood. 118: 6183-91. PMID 21989988 DOI: 10.1182/Blood-2011-06-363580  0.827
2011 Ahmad F, Boulaftali Y, Greene TK, Ouellette TD, Poncz M, Feske S, Bergmeier W. Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis. Journal of Thrombosis and Haemostasis : Jth. 9: 2077-86. PMID 21848641 DOI: 10.1111/J.1538-7836.2011.04474.X  0.8
2011 Kowalska MA, Krishnaswamy S, Rauova L, Zhai L, Hayes V, Amirikian K, Esko JD, Bougie DW, Aster RH, Cines DB, Poncz M. Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT. Blood. 118: 2882-8. PMID 21772054 DOI: 10.1182/Blood-2011-02-335208  0.388
2011 Lambert MP, Xiao L, Nguyen Y, Kowalska MA, Poncz M. The role of platelet factor 4 in radiation-induced thrombocytopenia. International Journal of Radiation Oncology, Biology, Physics. 80: 1533-40. PMID 21740995 DOI: 10.1016/J.Ijrobp.2011.03.039  0.466
2011 DiCarlo AL, Poncz M, Cassatt DR, Shah JR, Czarniecki CW, Maidment BW. Medical countermeasures for platelet regeneration after radiation exposure. Report of a workshop and guided discussion sponsored by the National Institute of Allergy and Infectious Diseases, Bethesda, MD, March 22–23, 2010. Radiation Research. 176: e0001-15. PMID 21545291 DOI: 10.1667/Rrol01.1  0.303
2011 DiCarlo AL, Poncz M, Cassatt DR, Shah JR, Czarniecki CW, Maidment BW. Development and licensure of medical countermeasures for platelet regeneration after radiation exposure. Radiation Research. 176: 134-7. PMID 21545289 DOI: 10.1667/Rr2610.1  0.343
2011 Stolla M, Stefanini L, Roden RC, Chavez M, Hirsch J, Greene T, Ouellette TD, Maloney SF, Diamond SL, Poncz M, Woulfe DS, Bergmeier W. The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy. Blood. 117: 1005-13. PMID 20971951 DOI: 10.1182/Blood-2010-07-297713  0.822
2011 Wang Y, Ono Y, Ikeda Y, Okamoto S, Murata M, Poncz M, Matsubara Y. Induction of Megakaryocytes From Fibroblasts by p45NF-E2/Maf Blood. 118: 908-908. DOI: 10.1182/Blood.V118.21.908.908  0.413
2011 Tutwiler V, Ahn HS, Cines DB, Camire RM, Poncz M, McKenzie S, Rauova L. Microfluidic and Flow Cytometric Studies Support a Role for Monocytes and Coated Platelets in the Prothrombotic State in Heparin-Induced Thrombocytopenia (HIT) Blood. 118: 539-539. DOI: 10.1182/Blood.V118.21.539.539  0.53
2011 Hayes VM, Cines DB, Poncz M, Rauova L. “Rolling Recruitment” of Endothelial Cell (EC) Activation in the Prothrombotic Nature of Heparin-Induced Thrombocytopenia (HIT) Blood. 118: 536-536. DOI: 10.1182/Blood.V118.21.536.536  0.496
2011 Kowalska MA, Zhao G, David G, Poncz M. Histones, Like Platelet Factor 4 (PF4), Affect Generation of Activated Protein C: Implications for the Pathogenesis of Severe Sepsis Blood. 118: 530-530. DOI: 10.1182/Blood.V118.21.530.530  0.365
2011 Sullivan S, Mills JA, Zhai L, Paluru P, Zhao G, Lu L, Lambert M, French DL, Poncz M, Gadue P. Targeted Gene Correction of Glanzmann Thrombasthenia Induced Pluripotent Stem Cells Restores Surface Expression and Fibrinogen Binding of Integrin αIIbβ3, Blood. 118: 4173-4173. DOI: 10.1182/Blood.V118.21.4173.4173  0.493
2011 Lambert M, Reznikov A, Xiao L, Poncz M. Platelet Factor 4 (PF4) Levels Are Inversely Correlated with Steady-State Platelet Counts and with Nadir Counts in Chemotherapy-Induced Thrombocytopenia (CIT), Blood. 118: 3527-3527. DOI: 10.1182/Blood.V118.21.3527.3527  0.508
2011 Andre P, Stolla M, Woulfe D, Chavez M, Bergmeier W, Rauova L, Cines DB, Poncz M, McKenzie S. Formation of Procoagulant Platelets in Heparin-Induced Thrombocytopenia (HIT) Follows a Unique Signaling Pathway Blood. 118: 197-197. DOI: 10.1182/Blood.V118.21.197.197  0.549
2011 Zhi H, Rauova L, Hayes VM, Crockett J, Gao C, Boylan B, Newman DK, McKenzie S, Cooley BC, Poncz M, Newman PJ. FcγRIIa Enhances Thrombus Growth in Vitro and in Vivo Blood. 118: 191-191. DOI: 10.1182/Blood.V118.21.191.191  0.562
2010 Greene TK, Schiviz A, Hoellriegl W, Poncz M, Muchitsch EM. Towards a standardization of the murine tail bleeding model. Journal of Thrombosis and Haemostasis : Jth. 8: 2820-2. PMID 21138523 DOI: 10.1111/J.1538-7836.2010.04084.X  0.754
2010 Fuentes R, Wang Y, Hirsch J, Wang C, Rauova L, Worthen GS, Kowalska MA, Poncz M. Infusion of mature megakaryocytes into mice yields functional platelets. The Journal of Clinical Investigation. 120: 3917-22. PMID 20972336 DOI: 10.1172/Jci43326  0.834
2010 Greene TK, Wang C, Hirsch JD, Zhai L, Gewirtz J, Thornton MA, Miao HZ, Pipe SW, Kaufman RJ, Camire RM, Arruda VR, Kowalska MA, Poncz M. In vivo efficacy of platelet-delivered, high specific activity factor VIII variants. Blood. 116: 6114-22. PMID 20852129 DOI: 10.1182/Blood-2010-06-293308  0.816
2010 Rauova L, Hirsch JD, Greene TK, Zhai L, Hayes VM, Kowalska MA, Cines DB, Poncz M. Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia. Blood. 116: 5021-31. PMID 20724543 DOI: 10.1182/Blood-2010-03-276964  0.836
2010 Mei J, Liu Y, Dai N, Favara M, Greene T, Jeyaseelan S, Poncz M, Lee JS, Worthen GS. CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity. 33: 106-17. PMID 20643340 DOI: 10.1016/J.Immuni.2010.07.009  0.793
2010 Zaitsev S, Spitzer D, Murciano JC, Ding BS, Tliba S, Kowalska MA, Marcos-Contreras OA, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR. Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. Blood. 115: 5241-8. PMID 20410503 DOI: 10.1182/Blood-2010-01-261610  0.408
2010 Gregory GD, Miccio A, Bersenev A, Wang Y, Hong W, Zhang Z, Poncz M, Tong W, Blobel GA. FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment. Blood. 115: 2156-66. PMID 20065294 DOI: 10.1182/Blood-2009-10-251280  0.356
2010 Kowalska MA, Rauova L, Poncz M. Role of the platelet chemokine platelet factor 4 (PF4) in hemostasis and thrombosis. Thrombosis Research. 125: 292-6. PMID 20004006 DOI: 10.1016/J.Thromres.2009.11.023  0.521
2010 Zaitsev S, Zaitzev S, Spitzer D, Murciano JC, Ding BS, Tliba S, Kowalska MA, Bdeir K, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR. Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis. The Journal of Pharmacology and Experimental Therapeutics. 332: 1022-31. PMID 19952305 DOI: 10.1124/Jpet.109.159194  0.413
2010 Miccio A, Wang Y, Hong W, Gregory GD, Wang H, Yu X, Choi JK, Shelat S, Tong W, Poncz M, Blobel GA. NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. The Embo Journal. 29: 442-56. PMID 19927129 DOI: 10.1038/Emboj.2009.336  0.352
2010 Fuentes R, Wang Y, Poncz M. Expansion of Platelets for Transfusion Blood. 116: SCI-47-SCI-47. DOI: 10.1182/Blood.V116.21.Sci-47.Sci-47  0.837
2010 Lambert M, Reznikov A, Nguyen Y, Rauova L, Poncz M. Platelet Factor 4 Levels Inversely Correlate with Platelet Transfusion Needs In Pediatric Patients Treated for Standard Risk Acute Lymphoblastic Leukemia Blood. 116: 725-725. DOI: 10.1182/Blood.V116.21.725.725  0.531
2010 Kowalska MA, Rauova L, Hayes V, Cines DB, Bougie DW, Aster RH, Krishnaswamy S, Poncz M. Heparin-Induced Thrombocytopenia Antibodies Inhibit PF4-Dependent Enhancement of Activated Protein C Formation by Binding to Antigenic Complexes Formed with the Chondroitin Sulfate Side-Chain of Thrombomodulin Blood. 116: 721-721. DOI: 10.1182/Blood.V116.21.721.721  0.397
2010 Suzuki A, Lian L, Zhao L, Min SH, Wang Y, Poncz M, Choi JK, Carpenter CL, Abrams CS. Mice That Lack RhoA In Their Platelets Have Normal Actin Dynamics, but Have Macrothrombocytopenia Blood. 116: 549-549. DOI: 10.1182/Blood.V116.21.549.549  0.555
2010 Wang Y, Meng R, Blobel G, Marks MS, Poncz M. Defective Production, Turnover, and Secretion of the Platelet α-Granule Protein P-Selectin In Mice with Disrupted FOG1-NuRD Interaction Blood. 116: 547-547. DOI: 10.1182/Blood.V116.21.547.547  0.51
2010 Fuentes R, Kowalska MA, Tliba S, Bougie DW, Aster RH, Cines DB, Muzykantov VR, Poncz M, Zaitsev S. Platelet-Targeted Pro-Urokinase as a Novel Thromboprophylaxis Fibrinolytic Strategy Blood. 116: 3339-3339. DOI: 10.1182/Blood.V116.21.3339.3339  0.823
2009 Rauova L, Arepally G, McKenzie SE, Konkle BA, Cines DB, Poncz M. Platelet and monocyte antigenic complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT). Journal of Thrombosis and Haemostasis : Jth. 249-52. PMID 19630810 DOI: 10.1111/J.1538-7836.2009.03373.X  0.48
2009 Lambert MP, Wang Y, Bdeir KH, Nguyen Y, Kowalska MA, Poncz M. Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes. Blood. 114: 2290-8. PMID 19605848 DOI: 10.1182/Blood-2009-04-216473  0.474
2009 Blue R, Kowalska MA, Hirsch J, Murcia M, Janczak CA, Harrington A, Jirouskova M, Li J, Fuentes R, Thornton MA, Filizola M, Poncz M, Coller BS. Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist. Blood. 114: 195-201. PMID 19414864 DOI: 10.1182/Blood-2008-08-169243  0.794
2009 Basani RB, Zhu H, Thornton MA, Soto CS, Degrado WF, Kowalska MA, Bennett JS, Poncz M. Species differences in small molecule binding to alpha IIb beta 3 are the result of sequence differences in 2 loops of the alpha IIb beta propeller. Blood. 113: 902-10. PMID 18987357 DOI: 10.1182/Blood-2008-09-177337  0.352
2009 Bougie DW, Birenbaum J, Rasmussen M, Poncz M, Aster RH. Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia. Blood. 113: 1105-11. PMID 18948570 DOI: 10.1182/Blood-2008-09-177279  0.367
2009 Greene TK, Wang C, Hirsch J, Miao H, Pipe SW, Kowalska MA, Poncz M. Strategies to Enhance the Efficacy of Platelet-Derived Factor (F) VIII: Studies with Inactivation Resistant FVIII (IR8) and Canine FVIII in Hemophilia A Mice. Blood. 114: 3496-3496. DOI: 10.1182/Blood.V114.22.3496.3496  0.844
2009 Rauova L, Hirsch J, Greene T, Nagaswami C, Cines DB, Weisel JW, Poncz M. Visualizing the Molecular and Cellular Basis of Heparin Induced Thrombocytopenia. Blood. 114: 228-228. DOI: 10.1182/Blood.V114.22.228.228  0.836
2009 Fuentes R, Wang Y, Hirsh J, Poncz M. Infusing Mature Megakaryocytes Into Mice Yields Functional Platelets: Biological and Clinical Implications. Blood. 114: 225-225. DOI: 10.1182/Blood.V114.22.225.225  0.807
2009 Stolla M, Stefanini L, Hirsch J, Roden C, Ouellette TD, Poncz M, Bergmeier W. The Signaling Molecule CalDAG-GEFI Represents a Novel Target for Antithrombotic Therapy. Blood. 114: 1077-1077. DOI: 10.1182/Blood.V114.22.1077.1077  0.498
2008 Neyman M, Gewirtz J, Poncz M. Analysis of the spatial and temporal characteristics of platelet-delivered factor VIII-based clots. Blood. 112: 1101-8. PMID 18559671 DOI: 10.1182/Blood-2008-04-152959  0.496
2008 Gewirtz J, Thornton MA, Rauova L, Poncz M. Platelet-delivered factor VIII provides limited resistance to anti-factor VIII inhibitors. Journal of Thrombosis and Haemostasis : Jth. 6: 1160-6. PMID 18433455 DOI: 10.1111/J.1538-7836.2008.02992.X  0.455
2008 Rauova L, Arepally GM, Cines DB, Poncz M. Monocytes Are a Particularly Favorable Target for Surface Platelet Factor 4 (PF4) Antigenic Complex Formation in Heparin-Induced Thrombocytopenia: New Insights into the Thrombotic Risk in HIT Blood. 112: 271-271. DOI: 10.1182/Blood.V112.11.271.271  0.505
2008 Kowalska MA, Amirikian K, Mosnier LO, Weiler H, Krishnaswamy S, Poncz M. Structural and Functional Studies to Define the Molecular Basis by Which Platelet Factor 4 (PF4) Increases Survival of Mice in Lipopolysaccharide (LPS)-Induced Endotoxicity Blood. 112: 19-19. DOI: 10.1182/Blood.V112.11.19.19  0.439
2008 Gregory GD, Wang Y, Hong W, Miccio A, Bersenev A, Yu X, Wang H, Choi J, Shelat S, Tong W, Poncz M, Blobel G. The GATA-1 Cofactor FOG-1 Recruits NuRD to Promote Normal Erythroid and Megakaryocyte Development and Maintain Lineage Fidelity by Restricting Mast Cell Gene Expression. Blood. 112: 1373-1373. DOI: 10.1182/Blood.V112.11.1373.1373  0.353
2007 Suvarna S, Espinasse B, Qi R, Lubica R, Poncz M, Cines DB, Wiesner MR, Arepally GM. Determinants of PF4/heparin immunogenicity. Blood. 110: 4253-60. PMID 17848616 DOI: 10.1182/Blood-2007-08-105098  0.379
2007 Kowalska MA, Mahmud SA, Lambert MP, Poncz M, Slungaard A. Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge. Blood. 110: 1903-5. PMID 17540840 DOI: 10.1182/Blood-2007-03-081901  0.469
2007 Lambert MP, Rauova L, Bailey M, Sola-Visner MC, Kowalska MA, Poncz M. Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications. Blood. 110: 1153-60. PMID 17495129 DOI: 10.1182/Blood-2007-01-067116  0.544
2007 Muntean AG, Pang L, Poncz M, Dowdy SF, Blobel GA, Crispino JD. Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization. Blood. 109: 5199-207. PMID 17317855 DOI: 10.1182/Blood-2006-11-059378  0.772
2007 Cines DB, Rauova L, Arepally G, Reilly MP, McKenzie SE, Sachais BS, Poncz M. Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly. Journal of Clinical Apheresis. 22: 31-6. PMID 17285619 DOI: 10.1002/Jca.20109  0.511
2007 Lambert MP, Wang Y, Kowalska MA, Poncz M. Negative Paracrine Effect of Platelet Factor 4 on Megakaryopoiesis Occurs through Lipoprotein Related Protein Receptor-1 on Megakaryocytes. Blood. 110: 97-97. DOI: 10.1182/Blood.V110.11.97.97  0.523
2007 Gewirtz JE, Rauova L, Poncz M. Characterizing Factor VIII Inhibitor Resistance of Platelet-Delivered Factor VIII in the Treatment of Hemophilia A. Blood. 110: 781-781. DOI: 10.1182/Blood.V110.11.781.781  0.486
2007 Hong W, Wang H, Wang Y, Choi JK, Shelat SG, Poncz M, Blobel GA. The GATA-1/FOG-1/NuRD Axis Is Essential for Normal Hematopoiesis. Blood. 110: 375-375. DOI: 10.1182/Blood.V110.11.375.375  0.393
2007 Rauova L, Cines DB, Poncz M. Defining the Role of Monocytes in Heparin-Induced Thrombocytopenia (HIT): Insights from a Murine HIT Model. Blood. 110: 280-280. DOI: 10.1182/Blood.V110.11.280.280  0.535
2007 Muntean A, Pang L, Poncz M, Dowdy S, Blobel G, Crispino J. Cyclin D/CDK4/6 kinase activity, regulated by GATA1, is required for megakaryocyte polyploidization Blood Cells, Molecules, and Diseases. 38: 133. DOI: 10.1182/Blood.V108.11.780.780  0.782
2006 Poncz M, Rauova L, Cines DB. The role of surface PF4: glycosaminoglycan complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT). Pathophysiology of Haemostasis and Thrombosis. 35: 46-9. PMID 16855346 DOI: 10.1159/000093543  0.312
2006 Pang L, Xue HH, Szalai G, Wang X, Wang Y, Watson DK, Leonard WJ, Blobel GA, Poncz M. Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. Blood. 108: 2198-206. PMID 16757682 DOI: 10.1182/Blood-2006-04-019760  0.785
2006 Schlachterman A, Schuettrumpf J, Liu JH, Furlan Freguia C, Freguia CF, Toso R, Poncz M, Camire RM, Arruda VR. Factor V Leiden improves in vivo hemostasis in murine hemophilia models. Journal of Thrombosis and Haemostasis : Jth. 3: 2730-7. PMID 16359510 DOI: 10.1111/J.1538-7836.2005.01639.X  0.378
2006 Rauova L, Zhai L, Kowalska MA, Arepally GM, Cines DB, Poncz M. Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. Blood. 107: 2346-53. PMID 16304054 DOI: 10.1182/Blood-2005-08-3122  0.485
2006 Rauova L, Cines DB, Poncz M. Platelet Factor 4 (PF4) Antigenic Complexes on the Macrophage Surface: Implications for the Pathogenesis of Heparin Induced Thrombocytopenia (HIT). Blood. 108: 94-94. DOI: 10.1182/Blood.V108.11.94.94  0.456
2006 Lambert MP, Rauova L, Kowalska MA, Poncz M. Murine In Vivo Studies Support Platelet Factor 4 as a Negative Autocrine of Megakaryopoiesis with Clinical and Therapeutic Implications. Blood. 108: 93-93. DOI: 10.1182/Blood.V108.11.93.93  0.481
2006 Kowalska MA, Lambert MP, Rauova L, Smith WJ, Mahmud SA, Poncz M, Slungaard A. Release of High Levels of Platelet Factor 4 (PF4) from Platelets Improves Survival after a Lethal Lipopolysaccharide (LPS) Challenge. Blood. 108: 61-61. DOI: 10.1182/Blood.V108.11.61.61  0.459
2006 Thornton MA, Poncz M, Badejogbin V. Peroxisome Proliferator-Activated Receptor gamma (PPARγ) Regulates CD36 Gene Expression in Megakaryocytic Cell Lines. Blood. 108: 4200-4200. DOI: 10.1182/Blood.V108.11.4200.4200  0.385
2006 Neyman M, Gewitz J, Poncz M. Platelet-Delivered Factor VIII (FVIII) Decreases Thrombus Stability. Blood. 108: 1602-1602. DOI: 10.1182/Blood.V108.11.1602.1602  0.45
2005 Pang L, Weiss MJ, Poncz M. Megakaryocyte biology and related disorders. The Journal of Clinical Investigation. 115: 3332-8. PMID 16322777 DOI: 10.1172/Jci26720  0.812
2005 Poncz M. Mechanistic basis of heparin-induced thrombocytopenia. Seminars in Thoracic and Cardiovascular Surgery. 17: 73-9. PMID 16104364 DOI: 10.1053/J.Semtcvs.2004.12.007  0.485
2005 Suvarna S, Rauova L, McCracken EK, Goss CM, Sachais BS, McKenzie SE, Reilly MP, Gunn MD, Cines DB, Poncz M, Arepally G. PF4/heparin complexes are T cell-dependent antigens. Blood. 106: 929-31. PMID 15845897 DOI: 10.1182/Blood-2004-12-4955  0.469
2005 Yarovoi H, Nurden AT, Montgomery RR, Nurden P, Poncz M. Intracellular interaction of von Willebrand factor and factor VIII depends on cellular context: lessons from platelet-expressed factor VIII. Blood. 105: 4674-6. PMID 15731176 DOI: 10.1182/Blood-2004-12-4701  0.576
2005 Lian L, Wang Y, Draznin J, Eslin D, Bennett JS, Poncz M, Wu D, Abrams CS. The relative role of PLCbeta and PI3Kgamma in platelet activation. Blood. 106: 110-7. PMID 15705797 DOI: 10.1182/Blood-2004-05-2005  0.521
2005 Rauova L, Poncz M, McKenzie SE, Reilly MP, Arepally G, Weisel JW, Nagaswami C, Cines DB, Sachais BS. Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood. 105: 131-8. PMID 15304392 DOI: 10.1182/Blood-2004-04-1544  0.479
2005 Reilly MP, Dessain SK, Taylor SM, Kowalska MA, Poncz M, Sachais BS, Cines DB, Arepally G, Williams KJ, McKenzie SE. Dietary Hypercholesterolemia Enhances Heparin-Induced Thrombocytopenia/Thrombosis: A Prothrombotic Risk Factor in a Transgenic Mouse Model. Blood. 106: 56-56. DOI: 10.1182/Blood.V106.11.56.56  0.46
2005 Rauova L, Zhai L, Kowalska MA, Arepally GM, Cines DB, Poncz M. Pathogenic Role of Surface Platelet Factor 4 Complexes in Heparin-Induced Thrombocytopenia: Diagnostic and Therapeutic Implications. Blood. 106: 55-55. DOI: 10.1182/Blood.V106.11.55.55  0.523
2005 Lambert MP, Kowalska MA, Poncz M. Platelet Factor 4 Regulates Platelet Count In Vivo: Implications for Platelet Recovery after Cytotoxic Therapy. Blood. 106: 3144-3144. DOI: 10.1182/Blood.V106.11.3144.3144  0.491
2005 Kowalska MA, Mahmud SA, Poncz M, Slungaard A. Endogenous Platelet PF4 Promotes In Vivo Activated Protein C (APC) Generation and Survival after Lethal Lipopolysaccharide Challenge in Mice: A Potential Physiologic Role for PF4. Blood. 106: 27-27. DOI: 10.1182/Blood.V106.11.27.27  0.421
2005 Basani RB, Thornton MA, Sachais BS, Kowalska MA, Degrado WF, Bennett JS, Poncz M. Two Specific Domains on the Upper Surface of the αIib β Propeller Determine the Sensitivity of αIibβ3 for RGD-Containing Peptides. Blood. 106: 2653-2653. DOI: 10.1182/Blood.V106.11.2653.2653  0.34
2004 Sachais BS, Higazi AA, Cines DB, Poncz M, Kowalska MA. Interactions of platelet factor 4 with the vessel wall. Seminars in Thrombosis and Hemostasis. 30: 351-8. PMID 15282658 DOI: 10.1055/S-2004-831048  0.509
2004 Eslin DE, Zhang C, Samuels KJ, Rauova L, Zhai L, Niewiarowski S, Cines DB, Poncz M, Kowalska MA. Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin. Blood. 104: 3173-80. PMID 14764524 DOI: 10.1182/Blood-2003-11-3994  0.507
2004 Perkowski SZ, Kowalska MA, Albelda SM, Bdeir K, Cines DB, Poncz M. Expression of Urokinase-Type Plasminogen Activator in Platelets Decreases Oxygen-Induced Lung Injury in Mice. Blood. 104: 688-688. DOI: 10.1182/Blood.V104.11.688.688  0.426
2004 Yarovoi H, Nurden P, Nurden AT, Montgomery RR, Poncz M. Factor (F) VIII Is Stored in Platelets Independent of Von Willebrand Factor (VWF). Blood. 104: 3524-3524. DOI: 10.1182/Blood.V104.11.3524.3524  0.534
2003 Pitsilos S, Hunt J, Mohler ER, Prabhakar AM, Poncz M, Dawicki J, Khalapyan TZ, Wolfe ML, Fairman R, Mitchell M, Carpenter J, Golden MA, Cines DB, Sachais BS. Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters. Thrombosis and Haemostasis. 90: 1112-20. PMID 14652645 DOI: 10.1160/Th03-02-0069  0.405
2003 Yarovoi HV, Kufrin D, Eslin DE, Thornton MA, Haberichter SL, Shi Q, Zhu H, Camire R, Fakharzadeh SS, Kowalska MA, Wilcox DA, Sachais BS, Montgomery RR, Poncz M. Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment. Blood. 102: 4006-13. PMID 12881300 DOI: 10.1182/Blood-2003-05-1519  0.5
2003 Kufrin D, Eslin DE, Bdeir K, Murciano JC, Kuo A, Kowalska MA, Degen JL, Sachais BS, Cines DB, Poncz M. Antithrombotic thrombocytes: Ectopic expression of urokinase-type plasminogen activator in platelets Blood. 102: 926-933. PMID 12689937 DOI: 10.1182/Blood-2003-01-0054  0.543
2003 Rozmyslowicz T, Majka M, Kijowski J, Murphy SL, Conover DO, Poncz M, Ratajczak J, Gaulton GN, Ratajczak MZ. Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. Aids (London, England). 17: 33-42. PMID 12478067 DOI: 10.1097/00002030-200301030-00006  0.4
2003 Nassar T, Sachais BS, Akkawi S, Kowalska MA, Bdeir K, Leitersdorf E, Hiss E, Ziporen L, Aviram M, Cines D, Poncz M, Higazi AA. Platelet factor 4 enhances the binding of oxidized low-density lipoprotein to vascular wall cells. The Journal of Biological Chemistry. 278: 6187-93. PMID 12466273 DOI: 10.1074/Jbc.M208894200  0.38
2003 Poncz M. Platelet message and microarrays Blood. 101: 2078-2078. DOI: 10.1182/Blood-2003-01-0138  0.503
2002 Thornton MA, Zhang C, Kowalska MA, Poncz M. Identification of distal regulatory regions in the human alpha IIb gene locus necessary for consistent, high-level megakaryocyte expression. Blood. 100: 3588-96. PMID 12393463 DOI: 10.1182/Blood-2002-05-1307  0.35
2002 Wang X, Crispino JD, Letting DL, Nakazawa M, Poncz M, Blobel GA. Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors. The Embo Journal. 21: 5225-34. PMID 12356738 DOI: 10.1093/Emboj/Cdf527  0.331
2002 Sachais BS, Kuo A, Nassar T, Morgan J, Kariko K, Williams KJ, Feldman M, Aviram M, Shah N, Jarett L, Poncz M, Cines DB, Higazi AA. Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic machinery, resulting in retention of low-density lipoprotein on the cell surface. Blood. 99: 3613-22. PMID 11986215 DOI: 10.1182/Blood.V99.10.3613  0.383
2002 Fang J, Hsu BY, MacMullen CM, Poncz M, Smith TJ, Stanley CA. Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations. The Biochemical Journal. 363: 81-7. PMID 11903050 DOI: 10.1042/0264-6021:3630081  0.303
2002 Li ZQ, Liu W, Park KS, Sachais BS, Arepally GM, Cines DB, Poncz M. Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody. Blood. 99: 1230-6. PMID 11830470 DOI: 10.1182/Blood.V99.4.1230  0.359
2001 Reilly MP, Taylor SM, Hartman NK, Arepally GM, Sachais BS, Cines DB, Poncz M, McKenzie SE. Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcγRIIA Blood. 98: 2442-2447. PMID 11588041 DOI: 10.1182/Blood.V98.8.2442  0.542
2001 Zhang C, Thornton MA, Anna Kowalska M, Sachis BS, Feldman M, Poncz M, McKenzie SE, Reilly MP. Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus Blood. 98: 610-617. PMID 11468158 DOI: 10.1182/Blood.V98.3.610  0.418
2001 Konkle BA, Bauer TL, Arepally G, Cines DB, Poncz M, McNulty S, Edie RN, Mannion JD. Heparin-induced thrombocytopenia: bovine versus porcine heparin in cardiopulmonary bypass surgery. The Annals of Thoracic Surgery. 71: 1920-4. PMID 11426769 DOI: 10.1016/S0003-4975(01)02534-6  0.407
2001 Derrick J, Shattil S, Poncz M, Gruppo R, Gartner K. Distinct Domains of αIIbβ3 Support Different Aspects of Outside-In Signal Transduction and Platelet Activation Induced by LSARLAF, an αIIbβ3 Interacting Peptide Thrombosis and Haemostasis. 86: 894-901. DOI: 10.1055/S-0037-1616147  0.492
2000 Yang J, Wu J, Kowalska MA, Dalvi A, Prevost N, O'Brien PJ, Manning D, Poncz M, Lucki I, Blendy JA, Brass LF. Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proceedings of the National Academy of Sciences of the United States of America. 97: 9984-9. PMID 10954748 DOI: 10.1073/Pnas.180194597  0.38
2000 Nichols KE, Crispino JD, Poncz M, White JG, Orkin SH, Maris JM, Weiss MJ. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA 1 Nature Genetics. 24: 266-270. PMID 10700180 DOI: 10.1038/73480  0.329
2000 Majka M, Janowska-Wieczorek A, Ratajczak J, Kowalska MA, Vilaire G, Pan ZK, Honczarenko M, Marquez LA, Poncz M, Ratajczak MZ. Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis Blood. 96: 4142-4151. DOI: 10.1182/Blood.V96.13.4142.H8004142_4142_4151  0.34
2000 Kowalska MA, Ratajczak MZ, Majka M, Jin J, Kunapuli S, Brass L, Poncz M. Stromal cell–derived factor-1 and macrophage-derived chemokine: 2 chemokines that activate platelets Blood. 96: 50-57. DOI: 10.1182/Blood.V96.1.50.013K40_50_57  0.534
2000 Kowalska MA, Ratajczak MZ, Majka M, Jin J, Kunapuli S, Brass L, Poncz M. Stromal cell–derived factor-1 and macrophage-derived chemokine: 2 chemokines that activate platelets Blood. 96: 50-57. DOI: 10.1182/blood.V96.1.50.013k40_50_57  0.441
2000 Arepally GM, Kamei S, Park KS, Kamei K, Li ZQ, Liu W, Siegel DL, Kisiel W, Cines DB, Poncz M. Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies Blood. 95: 1533-1540. DOI: 10.1182/Blood.V95.5.1533.005K01_1533_1540  0.37
2000 Basani RB, French DL, Vilaire G, Brown DL, Chen F, Coller BS, Derrick JM, Gartner TK, Bennett JS, Poncz M. A naturally occurring mutation near the amino terminus of αIIb defines a new region involved in ligand binding to αIIbβ3 Blood. 95: 180-188. DOI: 10.1182/Blood.V95.1.180.001K16_180_188  0.38
1999 Shou Y, Poncz M. Molecular biology studies with primary megakaryocytes. Methods in Molecular Medicine. 31: 347-54. PMID 21341010 DOI: 10.1385/1-59259-248-1:347  0.449
1999 Thornton MA, Poncz M. In vitro expansion of megakaryocytes from peripheral blood hematopoietic progenitors. Methods in Molecular Medicine. 31: 337-45. PMID 21341009 DOI: 10.1385/1-59259-248-1:337  0.32
1999 Song WJ, Sullivan MG, Legare RD, Hutchings S, Tan X, Kufrin D, Ratajczak J, Resende IC, Haworth C, Hock R, Loh M, Felix C, Roy DC, Busque L, Kurnit D, ... ... Poncz M, et al. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nature Genetics. 23: 166-75. PMID 10508512 DOI: 10.1038/13793  0.369
1999 Kowalska MA, Ratajczak J, Hoxie J, Brass LF, Gewirtz A, Poncz M, Ratajczak MZ. Megakaryocyte precursors, megakaryocytes and platelets express the HIV co-receptor CXCR4 on their surface: Determination of response to stromal- derived factor-1 by megakaryocytes and platelets British Journal of Haematology. 104: 220-229. PMID 10050701 DOI: 10.1046/J.1365-2141.1999.01169.X  0.504
1999 Thornton MA, Poncz M. Characterization of the Murine Platelet IIb Gene and Encoded cDNA Blood. 94: 3947-3950. DOI: 10.1182/Blood.V94.11.3947  0.373
1998 Shou Y, Baron S, Poncz M. An Sp1-binding silencer element is a critical negative regulator of the megakaryocyte-specific alphaIIb gene. The Journal of Biological Chemistry. 273: 5716-26. PMID 9488704 DOI: 10.1074/Jbc.273.10.5716  0.303
1998 Ziporen L, Li Z, Park K, Sabnekar P, Liu W, Arepally G, Shoenfeld Y, Kieber-Emmons T, Cines D, Poncz M. Defining an Antigenic Epitope on Platelet Factor 4 Associated With Heparin-Induced Thrombocytopenia Blood. 92: 3250-3259. DOI: 10.1182/Blood.V92.9.3250.421K23_3250_3259  0.396
1998 Arepally G, Rebbeck TR, Song W, Gilliland G, Maris JM, Poncz M. Evidence for Genetic Homogeneity in a Familial Platelet Disorder With Predisposition to Acute Myelogenous Leukemia (FPD/AML) Blood. 92: 2600-2602. DOI: 10.1182/Blood.V92.7.2600  0.318
1997 Zhang C, Gadue P, Scott E, Atchison M, Poncz M. Activation of the megakaryocyte-specific gene platelet basic protein (PBP) by the Ets family factor PU.1. The Journal of Biological Chemistry. 272: 26236-46. PMID 9334192 DOI: 10.1074/Jbc.272.42.26236  0.461
1997 Basani RB, Brown DL, Vilaire G, Bennett JS, Poncz M. A Leu117 → Trp Mutation Within the RGD-Peptide Cross-Linking Region of β3 Results in Glanzmann Thrombasthenia by Preventing αIIbβ3 Export to the Platelet Surface Blood. 90: 3082-3088. DOI: 10.1182/Blood.V90.8.3082  0.315
1997 Arepally G, McKenzie SE, Jiang X, Poncz M, Cines DB. FcγRIIA H/R131 Polymorphism, Subclass-Specific IgG Anti-Heparin/Platelet Factor 4 Antibodies and Clinical Course in Patients With Heparin-Induced Thrombocytopenia and Thrombosis Blood. 89: 370-375. DOI: 10.1182/Blood.V89.2.370  0.379
1997 Brass LF, Poncz M, Manning DR. G Proteins and the Early Events of Platelet Activation Advances in Molecular and Cell Biology. 18: 179-195. DOI: 10.1016/S1569-2558(08)60415-4  0.37
1996 Block KL, Shou Y, Thorton M, Poncz M. The regulated expression of a TATA-less, platelet-specific gene, alphaIIb. Stem Cells (Dayton, Ohio). 14: 38-47. PMID 11012201 DOI: 10.1002/Stem.5530140705  0.356
1996 Kahn MJ, Kieber-Emmons T, Vilaire G, Murali R, Poncz M, Bennett JS. Effect of mutagenesis of GPIIb amino acid 273 on the expression and conformation of the platelet integrin GPIIb-IIIa. Biochemistry. 35: 14304-11. PMID 8916916 DOI: 10.1021/Bi961702X  0.373
1996 Arepally G, Reynolds C, Tomaski A, Amiral J, Jawad A, Poncz M, Cines DB. Comparison of PF4/heparin ELISA assay with the 14C-serotonin release assay in the diagnosis of heparin-induced thrombocytopenia. American Journal of Clinical Pathology. 104: 648-54. PMID 8526207 DOI: 10.1093/Ajcp/104.6.648  0.435
1996 Block K, Shou Y, Poncz M. An Ets/Sp1 interaction in the 5'-flanking region of the megakaryocyte- specific alpha IIb gene appears to stabilize Sp1 binding and is essential for expression of this TATA-less gene Blood. 88: 2071-2080. DOI: 10.1182/Blood.V88.6.2071.Bloodjournal8862071  0.347
1996 Amiral J, Marfaing-Koka A, Wolf M, Alessi M, Tardy B, Boyer-Neumann C, Vissac A, Fressinaud E, Poncz M, Meyer D. Presence of autoantibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia Blood. 88: 410-416. DOI: 10.1182/Blood.V88.2.410.Bloodjournal882410  0.37
1995 Block KL, Poncz M. Platelet glycoprotein IIb gene expression as a model of megakaryocyte-specific expression. Stem Cells (Dayton, Ohio). 13: 135-45. PMID 7787779 DOI: 10.1002/Stem.5530130205  0.381
1995 Gewirtz A, Zhang J, Ratajczak J, Ratajczak M, Park K, Li C, Yan Z, Poncz M. Chemokine regulation of human megakaryocytopoiesis Blood. 86: 2559-2567. DOI: 10.1182/Blood.V86.7.2559.Bloodjournal8672559  0.396
1994 Poncz M, Rifat S, Coller BS, Newman PJ, Shattil SJ, Parrella T, Fortina P, Bennett JS. Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb. The Journal of Clinical Investigation. 93: 172-9. PMID 8282784 DOI: 10.1172/Jci116942  0.367
1994 Block KL, Ravid K, Phung QH, Poncz M. Characterization of regulatory elements in the 5'-flanking region of the rat GPIIb gene by studies in a primary rat marrow culture system. Blood. 84: 3385-93. PMID 7949093 DOI: 10.1182/Blood.V84.10.3385.3385  0.362
1994 Yan Z, Zhang J, Holt J, Stewart G, Niewiarowski S, Poncz M. Structural requirements of platelet chemokines for neutrophil activation Blood. 84: 2329-2339. DOI: 10.1182/Blood.V84.7.2329.2329  0.358
1993 Brass LF, Hoxie JA, Kieber-Emmons T, Manning DR, Poncz M, Woolkalis M. Agonist receptors and G proteins as mediators of platelet activation Advances in Experimental Medicine and Biology. 344: 17-36. PMID 8209785 DOI: 10.1007/978-1-4615-2994-1_2  0.462
1991 Burk CD, Newman PJ, Lyman S, Gill J, Coller BS, Poncz M. A deletion in the gene for glycoprotein IIb associated with Glanzmann's thrombasthenia. The Journal of Clinical Investigation. 87: 270-6. PMID 1702098 DOI: 10.1172/Jci114982  0.463
1991 Kolodziej M, Vilaire G, Rifat S, Poncz M, Bennett J. Effect of deletion of glycoprotein IIb exon 28 on the expression of the platelet glycoprotein IIb/IIIa complex Blood. 78: 2344-2353. DOI: 10.1182/Blood.V78.9.2344.Bloodjournal7892344  0.447
1991 Gagnon A, Manning D, Catani L, Gewirtz A, Poncz M, Brass L. Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes Blood. 78: 1247-1253. DOI: 10.1182/Blood.V78.5.1247.1247  0.373
1991 Goldberger A, Kolodziej M, Poncz M, Bennett J, Newman P. Effect of single amino acid substitutions on the formation of the PlA and Bak alloantigenic epitopes Blood. 78: 681-687. DOI: 10.1182/Blood.V78.3.681.681  0.379
1990 Heidenreich R, Eisman R, Surrey S, Delgrosso K, Bennett JS, Schwartz E, Poncz M. Organization of the gene for platelet glycoprotein IIb. Biochemistry. 29: 1232-44. PMID 2322558 DOI: 10.1021/Bi00457A020  0.359
1990 Eisman R, Surrey S, Ramachandran B, Schwartz E, Poncz M. Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. Blood. 76: 336-44. PMID 1695112 DOI: 10.1182/Blood.V76.2.336.336  0.402
1990 Park K, Rifat S, Eck H, Adachi K, Surrey S, Poncz M. Biologic and biochemic properties of recombinant platelet factor 4 demonstrate identity with the native protein Blood. 75: 1290-1295. DOI: 10.1182/Blood.V75.6.1290.1290  0.41
1990 Poncz M, Newman P. Analysis of rodent platelet glycoprotein IIb: evidence for evolutionarily conserved domains and alternative proteolytic processing Blood. 75: 1282-1289. DOI: 10.1182/Blood.V75.6.1282.1282  0.341
1988 Burk C, Ingram C, Weiner M, Rappaport EF, Schwartz E, Poncz M. A Taq 1 polymorphism for the human platelet glycoprotein IIIa gene (GP3A). Nucleic Acids Research. 16: 7216. PMID 2900503 DOI: 10.1093/Nar/16.14.7216  0.432
1988 Zimrin AB, Eisman R, Vilaire G, Schwartz E, Bennett JS, Poncz M. Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors. The Journal of Clinical Investigation. 81: 1470-5. PMID 2452834 DOI: 10.1172/Jci113478  0.381
1988 Fitzgerald LA, Poncz M, Steiner B, Rall SC, Bennett JS, Phillips DR. Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb. Biochemistry. 26: 8158-65. PMID 2450560 DOI: 10.1021/Bi00399A021  0.333
1987 Guzzo C, Weiner M, Rappaport E, Larocco P, Surrey S, Poncz M, Schwartz E. An Eco R1 polymorphism of a human platelet factor 4 (PF4) gene Nucleic Acids Research. 15: 380. PMID 2881257 DOI: 10.1093/Nar/15.1.380  0.394
1987 Heidenreich RA, Schwartz E, Surrev S, Bennett J, Larocco P, Eisman R, Poncz M. CDNA AND GENOMIC CLONES FOR HUMAN PLATELET GLYCOPROTEIN lib (GPIIb) Pediatric Research. 21: 290A-290A. DOI: 10.1203/00006450-198704010-00739  0.399
1987 Poncz M, Surrey S, LaRocco P, Weiss M, Rappaport E, Conway T, Schwartz E. Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line Blood. 69: 219-223. DOI: 10.1182/Blood.V69.1.219.219  0.311
1982 Poncz M, Solowiejczyk D, Harpel B, Mory Y, Schwartz E, Surrey S. Construction of human gene libraries from small amounts of peripheral blood: analysis of beta-like globin genes. Hemoglobin. 6: 27-36. PMID 7068433 DOI: 10.3109/03630268208996930  0.307
1981 Poncz M, Groenberg J, Russell MO, Schwartz E, Cohen AR. 852 THROMBOCYTOSIS IN PATIENTS WITH SICKLE CELL ANEMIA AND PNEUMONIA Pediatric Research. 15: 584-584. DOI: 10.1203/00006450-198104001-00877  0.474
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