| Year |
Citation |
Score |
| 2021 |
Campbell JE, Newgard CB. Mechanisms controlling pancreatic islet cell function in insulin secretion. Nature Reviews. Molecular Cell Biology. PMID 33398164 DOI: 10.1038/s41580-020-00317-7 |
0.416 |
|
| 2020 |
Zhang GF, Jensen MV, Gray SM, El K, Wang Y, Lu D, Becker TC, Campbell JE, Newgard CB. Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion. Cell Metabolism. PMID 33321098 DOI: 10.1016/j.cmet.2020.11.020 |
0.44 |
|
| 2020 |
White PJ, Lapworth AL, McGarrah RW, Kwee LC, Crown SB, Ilkayeva O, An J, Carson MW, Christopher BA, Ball JR, Davies MN, Kjalarsdottir L, George T, Muehlbauer MJ, Bain JR, ... ... Newgard CB, et al. Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion. Cell Reports. 33: 108375. PMID 33176135 DOI: 10.1016/j.celrep.2020.108375 |
0.32 |
|
| 2020 |
Huynh FK, Peterson BS, Anderson KA, Lin Z, Coakley AJ, Llaguno FMS, Nguyen TN, Campbell JE, Stephens SB, Newgard CB, Hirschey MD. Beta-cell specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice. American Journal of Physiology. Endocrinology and Metabolism. PMID 32865009 DOI: 10.1152/Ajpendo.00170.2020 |
0.498 |
|
| 2020 |
Liu Y, Kuang A, Talbot O, Bain JR, Muehlbauer MJ, Hayes MG, Ilkayeva OR, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL. Metabolomic and genetic associations with insulin resistance in pregnancy. Diabetologia. PMID 32556615 DOI: 10.1007/S00125-020-05198-1 |
0.368 |
|
| 2020 |
Hohmeier HE, Zhang L, Taylor B, Stephens S, Lu D, McNamara P, Laffitte B, Newgard CB. Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells. Plos One. 15: e0224344. PMID 32176701 DOI: 10.1371/Journal.Pone.0224344 |
0.406 |
|
| 2020 |
Liu Y, Kuang A, Bain JR, George T, Ilkayeva O, Mincey A, Muehlbauer M, Lowe LP, Metzger BE, Newgard CB, Scholtens D, Lowe W. 1344-P: Metabolomics Reveals Broad Scale Metabolic Changes in Gestational Diabetes Diabetes. 69. DOI: 10.2337/Db20-1344-P |
0.388 |
|
| 2019 |
McGarrah RW, Zhang GF, Christopher BA, Deleye Y, Walejko JM, Page S, Ilkayeva OR, White PJ, Newgard CB. Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats. American Journal of Physiology. Endocrinology and Metabolism. PMID 31794262 DOI: 10.1152/Ajpendo.00334.2019 |
0.407 |
|
| 2019 |
Softic S, Meyer JG, Wang GX, Gupta MK, Batista TM, Lauritzen HPMM, Fujisaka S, Serra D, Herrero L, Willoughby J, Fitzgerald K, Ilkayeva O, Newgard CB, Gibson BW, Schilling B, et al. Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins. Cell Metabolism. 30: 735-753.e4. PMID 31577934 DOI: 10.1016/J.Cmet.2019.09.003 |
0.44 |
|
| 2019 |
Kavanagh K, Day SM, Pait MC, Mortiz WR, Newgard CB, Ilkayeva O, Mcclain DA, Macauley SL. Type-2-Diabetes Alters CSF but Not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys. Frontiers in Neuroscience. 13: 843. PMID 31555072 DOI: 10.3389/Fnins.2019.00843 |
0.398 |
|
| 2019 |
Kadakia R, Talbot O, Kuang A, Bain JR, Muehlbauer MJ, Stevens RD, Ilkayeva OR, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL. Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries. The Journal of Clinical Endocrinology and Metabolism. 104: 4459-4472. PMID 31498869 DOI: 10.1210/Jc.2019-00238 |
0.313 |
|
| 2019 |
Wang G, Meyer JG, Cai W, Softic S, Li ME, Verdin E, Newgard C, Schilling B, Kahn CR. Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation. Molecular Cell. PMID 31000437 DOI: 10.1016/J.Molcel.2019.03.021 |
0.35 |
|
| 2019 |
Hohmeier HE, An J, Newgard CB. Improving human β-cell maturation in vitro. Nature Cell Biology. 21: 119-121. PMID 30710149 DOI: 10.1038/S41556-019-0277-6 |
0.341 |
|
| 2018 |
Meyer JG, Softic S, Basisty N, Rardin MJ, Verdin E, Gibson BW, Ilkayeva O, Newgard CB, Kahn CR, Schilling B. Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose. Plos One. 13: e0208973. PMID 30586434 DOI: 10.1371/Journal.Pone.0208973 |
0.362 |
|
| 2018 |
Ravi S, Parry TL, Willis MS, Lockyer P, Patterson C, Bain JR, Stevens RD, Ilkayeva OR, Newgard CB, Schisler JC. Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP. Journal of Cardiovascular Development and Disease. 5. PMID 30111698 DOI: 10.3390/Jcdd5030043 |
0.326 |
|
| 2018 |
Peterson BS, Campbell JE, Ilkayeva O, Grimsrud PA, Hirschey MD, Newgard CB. Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition. Cell Reports. 24: 209-223.e6. PMID 29972782 DOI: 10.1016/J.Celrep.2018.05.088 |
0.5 |
|
| 2018 |
Shantavasinkul PC, Muehlbauer MJ, Bain JR, Ilkayeva OR, Craig DM, Newgard CB, Svetkey LP, Shah SH, Torquati A. Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid. Surgery For Obesity and Related Diseases : Official Journal of the American Society For Bariatric Surgery. PMID 29805089 DOI: 10.1016/J.Soard.2018.03.033 |
0.305 |
|
| 2018 |
White PJ, McGarrah RW, Grimsrud PA, Tso SC, Yang WH, Haldeman JM, Grenier-Larouche T, An J, Lapworth AL, Astapova I, Hannou SA, George T, Arlotto M, Olson LB, Lai M, ... ... Newgard CB, et al. The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase. Cell Metabolism. PMID 29779826 DOI: 10.1016/J.Cmet.2018.04.015 |
0.451 |
|
| 2018 |
Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR. Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. The Journal of Clinical Investigation. 128: 1199. PMID 29493547 DOI: 10.1172/JCI99009 |
0.353 |
|
| 2018 |
Chondronikola M, Magkos F, Yoshino J, Okunade AL, Patterson BW, Muehlbauer MJ, Newgard CB, Klein S. Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. Obesity (Silver Spring, Md.). PMID 29476613 DOI: 10.1002/Oby.22129 |
0.466 |
|
| 2018 |
Sugi K, Hsieh PN, Ilkayeva O, Shelkay S, Moroney B, Baadh P, Haynes B, Pophal M, Fan L, Newgard CB, Prosdocimo DA, Jain MK. Kruppel-like factor 15 is required for the cardiac adaptive response to fasting. Plos One. 13: e0192376. PMID 29408889 DOI: 10.1371/Journal.Pone.0192376 |
0.302 |
|
| 2018 |
WHITE PJ, MCGARRAH RW, GRIMSRUD PA, YANG W, ZHANG G, HALDEMAN JM, ARLOTTO M, ILKAYEVA O, WYNN RM, CHUANG DT, NEWGARD CB. Integration of BCAA and Lipid Metabolism by the BCKDH Kinase and Phosphatase Diabetes. 67: 1874-P. DOI: 10.2337/Db18-1874-P |
0.421 |
|
| 2017 |
Jensen BC, Parry TL, Huang W, Beak JY, Ilaiwy A, Bain JR, Newgard CB, Muehlbauer MJ, Patterson C, Johnson GL, Willis MS. Effects of the Kinase Inhibitor Sorafenib on Heart, Muscle, Liver, and Plasma Metabolism In Vivo using Non-Targeted Metabolomics Analysis. British Journal of Pharmacology. PMID 28977680 DOI: 10.1111/Bph.14062 |
0.326 |
|
| 2017 |
Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR. Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. The Journal of Clinical Investigation. PMID 28972537 DOI: 10.1172/Jci94585 |
0.497 |
|
| 2017 |
Jensen MV, Gooding JR, Ferdaoussi M, Dai XQ, Peterson BS, MacDonald PE, Newgard CB. Metabolomics applied to islet nutrient sensing mechanisms. Diabetes, Obesity & Metabolism. 19: 90-94. PMID 28880482 DOI: 10.1111/Dom.13010 |
0.456 |
|
| 2017 |
Stephens SB, Edwards RJ, Sadahiro M, Lin WJ, Jiang C, Salton SR, Newgard CB. The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis. Cell Reports. 20: 2480-2489. PMID 28877479 DOI: 10.1016/J.Celrep.2017.08.050 |
0.416 |
|
| 2017 |
Abdullah M, Kornegay JN, Honcoop A, Parry TL, Balog-Alvarez CJ, O'Neal SK, Bain JR, Muehlbauer MJ, Newgard CB, Patterson C, Willis MS. Non-Targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo. Metabolites. 7. PMID 28758940 DOI: 10.3390/Metabo7030038 |
0.301 |
|
| 2017 |
Jacob S, Nodzenski M, Reisetter AC, Bain JR, Muehlbauer MJ, Stevens RD, Ilkayeva OR, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL. Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups. Diabetes Care. 40: 911-919. PMID 28637889 DOI: 10.2337/Dc16-2453 |
0.393 |
|
| 2017 |
Lowe WL, Bain JR, Nodzenski M, Reisetter AC, Muehlbauer MJ, Stevens RD, Ilkayeva OR, Lowe LP, Metzger BE, Newgard CB, Scholtens DM. Maternal BMI and Glycemia Impact the Fetal Metabolome. Diabetes Care. 40: 902-910. PMID 28637888 DOI: 10.2337/Dc16-2452 |
0.301 |
|
| 2017 |
Fu J, Dai X, Plummer G, Suzuki K, Bautista A, Githaka JM, Senior L, Jensen M, Greitzer-Antes D, Manning Fox JE, Gaisano HY, Newgard CB, Touret N, MacDonald PE. Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction. Diabetes. PMID 28607108 DOI: 10.2337/Db16-1170 |
0.39 |
|
| 2017 |
Dean ED, Li M, Prasad N, Wisniewski SN, Von Deylen A, Spaeth J, Maddison L, Botros A, Sedgeman LR, Bozadjieva N, Ilkayeva O, Coldren A, Poffenberger G, Shostak A, Semich MC, ... ... Newgard C, et al. Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation. Cell Metabolism. 25: 1362-1373.e5. PMID 28591638 DOI: 10.1016/J.Cmet.2017.05.011 |
0.352 |
|
| 2017 |
Hayes HL, Peterson BS, Haldeman JM, Newgard CB, Hohmeier HE, Stephens SB. Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival. Plos One. 12: e0172567. PMID 28212395 DOI: 10.1371/Journal.Pone.0172567 |
0.32 |
|
| 2016 |
Ilaiwy A, Liu M, Parry TL, Bain JR, Newgard CB, Schisler JC, Muehlbauer MJ, Despa F, Willis MS. Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo. Metabolomics : Official Journal of the Metabolomic Society. 12. PMID 28775675 DOI: 10.1007/S11306-016-1022-9 |
0.307 |
|
| 2016 |
Sandler V, Reisetter AC, Bain JR, Muehlbauer MJ, Nodzenski M, Stevens RD, Ilkayeva O, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL. Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes. Diabetologia. PMID 27981358 DOI: 10.1007/S00125-016-4182-2 |
0.31 |
|
| 2016 |
Ribel-Madsen A, Hellgren LI, Brøns C, Ribel-Madsen R, Newgard CB, Vaag AA. Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short-term high-fat overfeeding. Physiological Reports. 4. PMID 27956466 DOI: 10.14814/Phy2.13044 |
0.447 |
|
| 2016 |
Ribel-Madsen A, Ribel-Madsen R, Brøns C, Newgard CB, Vaag AA, Hellgren LI. Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men. Physiological Reports. 4. PMID 27694528 DOI: 10.14814/Phy2.12977 |
0.395 |
|
| 2016 |
Gurley JM, Ilkayeva O, Jackson RM, Griesel BA, White P, Matsuzaki S, Qaisar R, Van Remmen H, Humphries KM, Newgard CB, Olson AL. Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism. Diabetes. PMID 27679559 DOI: 10.2337/Db16-0709 |
0.467 |
|
| 2016 |
Hayes HL, Zhang L, Becker TC, Haldeman J, Stephens SB, Arlotto M, Moss LG, Newgard CB, Hohmeier HE. A Pdx-1-regulated soluble factor activates rat and human islet cell proliferation. Molecular and Cellular Biology. PMID 27620967 DOI: 10.1128/Mcb.00103-16 |
0.376 |
|
| 2016 |
Guthrie G, Kulkarni M, Vlaardingerbroek H, Stoll B, Ng K, Martin C, Belmont J, Hadsell D, Heird W, Newgard CB, Olutoye O, van Goudoever J, Lauridsen C, He X, Schuchman EH, et al. Multi-Omic Profiles of Hepatic Metabolism in TPN-fed Preterm Pigs Administered New Generation Lipid Emulsions. Journal of Lipid Research. PMID 27474222 DOI: 10.1194/Jlr.M069526 |
0.36 |
|
| 2016 |
White PJ, Lapworth AL, An J, Wang L, McGarrah RW, Stevens RD, Ilkayeva O, George T, Muehlbauer MJ, Bain JR, Trimmer JK, Brosnan MJ, Rolph TP, Newgard CB. Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export. Molecular Metabolism. 5: 538-51. PMID 27408778 DOI: 10.1016/J.Molmet.2016.04.006 |
0.416 |
|
| 2016 |
Kucejova B, Duarte J, Satapati S, Fu X, Ilkayeva O, Newgard CB, Brugarolas J, Burgess SC. Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity. Cell Reports. PMID 27346353 DOI: 10.1016/J.Celrep.2016.06.006 |
0.47 |
|
| 2016 |
Scholtens DM, Bain JR, Reisetter AC, Muehlbauer MJ, Nodzenski M, Stevens RD, Ilkayeva O, Lowe LP, Metzger BE, Newgard CB, Lowe WL. Metabolic networks and metabolites underlie associations between maternal glucose during pregnancy and newborn size at birth. Diabetes. PMID 27207545 DOI: 10.2337/Db15-1748 |
0.404 |
|
| 2016 |
Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn JY, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui WJ, Williams NS, ... ... Newgard CB, et al. Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. Circulation. PMID 27059949 DOI: 10.1161/Circulationaha.115.020226 |
0.36 |
|
| 2016 |
Zhang W, Bu SY, Mashek MT, O-Sullivan I, Sibai Z, Khan SA, Ilkayeva O, Newgard CB, Mashek DG, Unterman TG. Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins. Cell Reports. PMID 27050511 DOI: 10.1016/J.Celrep.2016.03.021 |
0.447 |
|
| 2016 |
Marcelo KL, Ribar T, Means CR, Tsimelzon A, Stevens RD, Ilkayeva O, Bain JR, Hilsenbeck SG, Newgard CB, Means AR, York B. Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism. Molecular Endocrinology (Baltimore, Md.). me20161021. PMID 27003444 DOI: 10.1210/Me.2016-1021 |
0.42 |
|
| 2016 |
Sommer F, Ståhlman M, Ilkayeva O, Arnemo JM, Kindberg J, Josefsson J, Newgard CB, Fröbert O, Bäckhed F. The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos. Cell Reports. 14: 1655-61. PMID 26854221 DOI: 10.1016/J.Celrep.2016.01.026 |
0.367 |
|
| 2016 |
White PJ, Lapworth AL, An J, Wang L, McGarrah RW, Stevens RD, Ilkayeva O, George T, Muehlbauer MJ, Bain JR, Trimmer JK, Brosnan MJ, Rolph TP, Newgard CB. Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export Molecular Metabolism. DOI: 10.1016/j.molmet.2016.04.006 |
0.329 |
|
| 2015 |
Banerjee R, He J, Spaniel C, Quintana MT, Wang Z, Bain J, Newgard CB, Muehlbauer MJ, Willis MS. Non-targeted metabolomics analysis of cardiac Muscle Ring Finger-1 (MuRF1), MuRF2, and MuRF3 in vivo reveals novel and redundant metabolic changes. Metabolomics : Official Journal of the Metabolomic Society. 11: 312-322. PMID 28325996 DOI: 10.1007/S11306-014-0695-1 |
0.321 |
|
| 2015 |
Gooding JR, Jensen MV, Dai X, Wenner BR, Lu D, Arumugam R, Ferdaoussi M, MacDonald PE, Newgard CB. Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism. Cell Reports. PMID 26411681 DOI: 10.1016/J.Celrep.2015.08.072 |
0.508 |
|
| 2015 |
Banerjee R, Bultman SJ, Holley D, Hillhouse C, Bain JR, Newgard CB, Muehlbauer MJ, Willis MS. Non-targeted metabolomics of Brg1/Brm double-mutant cardiomyocytes reveals a novel role for SWI/SNF complexes in metabolic homeostasis. Metabolomics : Official Journal of the Metabolomic Society. 11: 1287-1301. PMID 26392817 DOI: 10.1007/S11306-015-0786-7 |
0.354 |
|
| 2015 |
Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, ... ... Newgard CB, et al. Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells. The Journal of Clinical Investigation. PMID 26389676 DOI: 10.1172/Jci82498 |
0.514 |
|
| 2015 |
Wagner M, Choi S, Panzitt K, Mamrosh JL, Man Lee J, Zaufel A, Xiao R, Wooton-Kee R, Ståhlman M, Newgard CB, Borén J, Moore DD. LRH-1 is a critical determinant of methyl-pool metabolism. Hepatology (Baltimore, Md.). PMID 26267291 DOI: 10.1002/Hep.28124 |
0.309 |
|
| 2015 |
Glynn EL, Piner LW, Huffman KM, Slentz CA, Elliot-Penry L, AbouAssi H, White PJ, Bain JR, Muehlbauer MJ, Ilkayeva OR, Stevens RD, Porter Starr KN, Bales CW, Volpi E, Brosnan MJ, ... ... Newgard CB, et al. Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans. Diabetologia. 58: 2324-35. PMID 26254576 DOI: 10.1007/S00125-015-3705-6 |
0.384 |
|
| 2015 |
He J, Quintana MT, Sullivan J, L Parry T, J Grevengoed T, Schisler JC, Hill JA, Yates CC, Mapanga RF, Essop MF, Stansfield WE, Bain JR, Newgard CB, Muehlbauer MJ, Han Y, et al. MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet. Cardiovascular Diabetology. 14: 97. PMID 26242235 DOI: 10.1186/S12933-015-0252-X |
0.354 |
|
| 2015 |
Shang J, Li J, Keller MP, Hohmeier HE, Wang Y, Feng Y, Zhou HH, Shen X, Rabaglia M, Soni M, Attie AD, Newgard CB, Thornberry NA, Howard AD, Zhou YP. Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells. Molecular Endocrinology (Baltimore, Md.). 29: 1243-53. PMID 26218441 DOI: 10.1210/Me.2014-1335 |
0.349 |
|
| 2015 |
Quintana MT, He J, Sullivan J, Grevengoed T, Schisler J, Han Y, Hill JA, Yates CC, Stansfield WE, Mapanga RF, Essop MF, Muehlbauer MJ, Newgard CB, Bain JR, Willis MS. Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet. Bmc Endocrine Disorders. 15: 36. PMID 26215257 DOI: 10.1186/S12902-015-0028-Z |
0.321 |
|
| 2015 |
Rodríguez JE, Liao JY, He J, Schisler JC, Newgard CB, Drujan D, Glass DL, Frederick CB, Yoder BC, Lalush DS, Patterson C, Willis MS. The Ubiquitin Ligase MuRF1 Regulates PPARα Activity in the Heart by Enhancing Nuclear Export via Monoubiquitination. Molecular and Cellular Endocrinology. PMID 26116825 DOI: 10.1016/J.Mce.2015.06.008 |
0.311 |
|
| 2015 |
Gooding JR, Jensen MV, Newgard CB. Metabolomics applied to the pancreatic islet. Archives of Biochemistry and Biophysics. PMID 26116790 DOI: 10.1016/J.Abb.2015.06.013 |
0.352 |
|
| 2015 |
Kang YK, Putluri N, Maity S, Tsimelzon A, Ilkayeva O, Mo Q, Lonard D, Michailidis G, Sreekumar A, Newgard CB, Wang M, Tsai SY, Tsai MJ, O'Malley BW. CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC. Plos Genetics. 11: e1005116. PMID 25830341 DOI: 10.1371/Journal.Pgen.1005116 |
0.351 |
|
| 2015 |
Ali S, Ussher JR, Baggio LL, Kabir MG, Charron MJ, Ilkayeva O, Newgard CB, Drucker DJ. Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction. Molecular Metabolism. 4: 132-43. PMID 25685700 DOI: 10.1016/J.Molmet.2014.11.005 |
0.31 |
|
| 2015 |
Guo C, Ludvik AE, Arlotto ME, Hayes MG, Armstrong LL, Scholtens DM, Brown CD, Newgard CB, Becker TC, Layden BT, Lowe WL, Reddy TE. Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1. Nature Communications. 6: 6069. PMID 25648650 DOI: 10.1038/Ncomms7069 |
0.424 |
|
| 2015 |
Gerriets VA, Kishton RJ, Nichols AG, Macintyre AN, Inoue M, Ilkayeva O, Winter PS, Liu X, Priyadharshini B, Slawinska ME, Haeberli L, Huck C, Turka LA, Wood KC, Hale LP, ... ... Newgard CB, et al. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. The Journal of Clinical Investigation. 125: 194-207. PMID 25437876 DOI: 10.1172/Jci76012 |
0.307 |
|
| 2015 |
Palmer ND, Stevens RD, Antinozzi PA, Anderson A, Bergman RN, Wagenknecht LE, Newgard CB, Bowden DW. Metabolomic profile associated with insulin resistance and conversion to diabetes in the Insulin Resistance Atherosclerosis Study. The Journal of Clinical Endocrinology and Metabolism. 100: E463-8. PMID 25423564 DOI: 10.1210/Jc.2014-2357 |
0.416 |
|
| 2015 |
Teh JT, Zhu WL, Ilkayeva OR, Li Y, Gooding J, Casey PJ, Summers SA, Newgard CB, Wang M. Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism. Oncogene. 34: 3296-304. PMID 25151967 DOI: 10.1038/Onc.2014.260 |
0.354 |
|
| 2015 |
Li LO, Grevengoed TJ, Paul DS, Ilkayeva O, Koves TR, Pascual F, Newgard CB, Muoio DM, Coleman RA. Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis. Diabetes. 64: 23-35. PMID 25071025 DOI: 10.2337/Db13-1070 |
0.44 |
|
| 2014 |
Baskin KK, Grueter CE, Kusminski CM, Holland WL, Bookout AL, Satapati S, Kong YM, Burgess SC, Malloy CR, Scherer PE, Newgard CB, Bassel-Duby R, Olson EN. MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver. Embo Molecular Medicine. 6: 1610-21. PMID 25422356 DOI: 10.15252/Emmm.201404218 |
0.313 |
|
| 2014 |
Muoio DM, Newgard CB. Diabetes: The good in fat. Nature. 516: 49-50. PMID 25409152 DOI: 10.1038/Nature14070 |
0.369 |
|
| 2014 |
Shin AC, Fasshauer M, Filatova N, Grundell LA, Zielinski E, Zhou JY, Scherer T, Lindtner C, White PJ, Lapworth AL, Ilkayeva O, Knippschild U, Wolf AM, Scheja L, Grove KL, ... ... Newgard CB, et al. Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. Cell Metabolism. 20: 898-909. PMID 25307860 DOI: 10.1016/J.Cmet.2014.09.003 |
0.46 |
|
| 2014 |
Tannour-Louet M, York B, Tang K, Stashi E, Bouguerra H, Zhou S, Yu H, Wong LJ, Stevens RD, Xu J, Newgard CB, O'Malley BW, Louet JF. Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis. Molecular Endocrinology (Baltimore, Md.). 28: 1707-18. PMID 25148457 DOI: 10.1210/Me.2014-1083 |
0.373 |
|
| 2014 |
Newgard CB, Pessin JE. Recent progress in metabolic signaling pathways regulating aging and life span. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 69: S21-7. PMID 24833582 DOI: 10.1093/Gerona/Glu058 |
0.367 |
|
| 2014 |
Tripathy S, Lytle KA, Stevens RD, Bain JR, Newgard CB, Greenberg AS, Huang LS, Jump DB. Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice. Journal of Lipid Research. 55: 1448-1464. PMID 24814977 DOI: 10.1194/Jlr.M050062 |
0.359 |
|
| 2014 |
Tessem JS, Moss LG, Chao LC, Arlotto M, Lu D, Jensen MV, Stephens SB, Tontonoz P, Hohmeier HE, Newgard CB. Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. Proceedings of the National Academy of Sciences of the United States of America. 111: 5242-7. PMID 24706823 DOI: 10.1073/Pnas.1320953111 |
0.716 |
|
| 2014 |
Seiler SE, Martin OJ, Noland RC, Slentz DH, DeBalsi KL, Ilkayeva OR, An J, Newgard CB, Koves TR, Muoio DM. Obesity and lipid stress inhibit carnitine acetyltransferase activity. Journal of Lipid Research. 55: 635-44. PMID 24395925 DOI: 10.1194/Jlr.M043448 |
0.413 |
|
| 2014 |
Thalacker-Mercer AE, Ingram KH, Guo F, Ilkayeva O, Newgard CB, Garvey WT. BMI, RQ, diabetes, and sex affect the relationships between amino acids and clamp measures of insulin action in humans. Diabetes. 63: 791-800. PMID 24130332 DOI: 10.2337/Db13-0396 |
0.436 |
|
| 2014 |
Scholtens DM, Muehlbauer MJ, Daya NR, Stevens RD, Dyer AR, Lowe LP, Metzger BE, Newgard CB, Bain JR, Lowe WL. Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy. Diabetes Care. 37: 158-66. PMID 23990511 DOI: 10.2337/Dc13-0989 |
0.385 |
|
| 2014 |
Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y, Ilkayeva OR, Gooding J, Ching J, Zhou J, Martinez L, Xie S, Bay BH, Summers SA, Newgard CB, et al. Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. Hepatology (Baltimore, Md.). 59: 1366-80. PMID 23929677 DOI: 10.1002/Hep.26667 |
0.372 |
|
| 2014 |
Khoo CM, Muehlbauer MJ, Stevens RD, Pamuklar Z, Chen J, Newgard CB, Torquati A. Postprandial metabolite profiles reveal differential nutrient handling after bariatric surgery compared with matched caloric restriction. Annals of Surgery. 259: 687-93. PMID 23787216 DOI: 10.1097/Sla.0B013E318296633F |
0.313 |
|
| 2014 |
McGarrah R, Craig DM, Haynes C, Hauser E, Newgard CB, Gregory SG, Kraus W, Shah S. Omics Profiling Highlights Endoplasmic Reticulum-Associated Degradation And Ubiquitin Proteasome Pathways In Insulin Resistance And Glycemic Control Journal of the American College of Cardiology. 63. DOI: 10.1016/S0735-1097(14)61603-X |
0.352 |
|
| 2013 |
Lamonte G, Tang X, Chen JL, Wu J, Ding CK, Keenan MM, Sangokoya C, Kung HN, Ilkayeva O, Boros LG, Newgard CB, Chi JT. Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress. Cancer & Metabolism. 1: 23. PMID 24359630 DOI: 10.1186/2049-3002-1-23 |
0.358 |
|
| 2013 |
Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, ... ... Newgard CB, et al. SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metabolism. 18: 920-33. PMID 24315375 DOI: 10.1016/J.Cmet.2013.11.013 |
0.358 |
|
| 2013 |
Patel MJ, Batch BC, Svetkey LP, Bain JR, Turer CB, Haynes C, Muehlbauer MJ, Stevens RD, Newgard CB, Shah SH. Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults. Omics : a Journal of Integrative Biology. 17: 627-35. PMID 24117402 DOI: 10.1089/Omi.2013.0031 |
0.301 |
|
| 2013 |
Peek CB, Affinati AH, Ramsey KM, Kuo HY, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C, Levine DC, Bacsik DJ, Gius D, Newgard CB, Goetzman E, et al. Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science (New York, N.Y.). 342: 1243417. PMID 24051248 DOI: 10.1126/Science.1243417 |
0.305 |
|
| 2013 |
Hayes HL, Moss LG, Schisler JC, Haldeman JM, Zhang Z, Rosenberg PB, Newgard CB, Hohmeier HE. Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2. Molecular and Cellular Biology. 33: 4017-29. PMID 23938296 DOI: 10.1128/Mcb.00469-13 |
0.358 |
|
| 2013 |
Jing E, O'Neill BT, Rardin MJ, Kleinridders A, Ilkeyeva OR, Ussar S, Bain JR, Lee KY, Verdin EM, Newgard CB, Gibson BW, Kahn CR. Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes. 62: 3404-17. PMID 23835326 DOI: 10.2337/Db12-1650 |
0.388 |
|
| 2013 |
Jensen MV, Haldeman JM, Zhang H, Lu D, Huising MO, Vale WW, Hohmeier HE, Rosenberg P, Newgard CB. Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion. The Journal of Biological Chemistry. 288: 23128-40. PMID 23788641 DOI: 10.1074/Jbc.M113.491654 |
0.413 |
|
| 2013 |
Klett EL, Chen S, Edin ML, Li LO, Ilkayeva O, Zeldin DC, Newgard CB, Coleman RA. Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion. The Journal of Biological Chemistry. 288: 21618-29. PMID 23766516 DOI: 10.1074/Jbc.M113.481077 |
0.522 |
|
| 2013 |
Magkos F, Bradley D, Schweitzer GG, Finck BN, Eagon JC, Ilkayeva O, Newgard CB, Klein S. Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism. Diabetes. 62: 2757-61. PMID 23610059 DOI: 10.2337/Db13-0185 |
0.422 |
|
| 2013 |
Johnson ES, Lindblom KR, Robeson A, Stevens RD, Ilkayeva OR, Newgard CB, Kornbluth S, Andersen JL. Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis. The Journal of Biological Chemistry. 288: 14463-75. PMID 23553630 DOI: 10.1074/Jbc.M112.437210 |
0.322 |
|
| 2013 |
York B, Sagen JV, Tsimelzon A, Louet JF, Chopra AR, Reineke EL, Zhou S, Stevens RD, Wenner BR, Ilkayeva O, Bain JR, Xu J, Hilsenbeck SG, Newgard CB, O'Malley BW. Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family. Molecular Endocrinology (Baltimore, Md.). 27: 366-80. PMID 23315938 DOI: 10.1210/Me.2012-1324 |
0.37 |
|
| 2013 |
Coppola A, Wenner BR, Ilkayeva O, Stevens RD, Maggioni M, Slotkin TA, Levin ED, Newgard CB. Branched-chain amino acids alter neurobehavioral function in rats. American Journal of Physiology. Endocrinology and Metabolism. 304: E405-13. PMID 23249694 DOI: 10.1152/Ajpendo.00373.2012 |
0.331 |
|
| 2013 |
Li XN, Herrington J, Petrov A, Ge L, Eiermann G, Xiong Y, Jensen MV, Hohmeier HE, Newgard CB, Garcia ML, Wagner M, Zhang BB, Thornberry NA, Howard AD, Kaczorowski GJ, et al. The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. The Journal of Pharmacology and Experimental Therapeutics. 344: 407-16. PMID 23161216 DOI: 10.1124/Jpet.112.199083 |
0.442 |
|
| 2013 |
Patel SG, Hsu JW, Jahoor F, Coraza I, Bain JR, Stevens RD, Iyer D, Nalini R, Ozer K, Hampe CS, Newgard CB, Balasubramanyam A. Pathogenesis of Aâ»Î²âº ketosis-prone diabetes. Diabetes. 62: 912-22. PMID 23160531 DOI: 10.2337/Db12-0624 |
0.322 |
|
| 2012 |
Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin MJ, An D, Lee KY, Ilkayeva OR, Zingaretti CM, Emanuelli B, Smyth G, Cinti S, Newgard CB, Gibson BW, et al. Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. Cell Metabolism. 16: 765-76. PMID 23168219 DOI: 10.1016/J.Cmet.2012.10.016 |
0.345 |
|
| 2012 |
Chao LC, Wroblewski K, Ilkayeva OR, Stevens RD, Bain J, Meyer GA, Schenk S, Martinez L, Vergnes L, Narkar VA, Drew BG, Hong C, Boyadjian R, Hevener AL, Evans RM, ... ... Newgard CB, et al. Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. Journal of Lipid Research. 53: 2610-9. PMID 23028113 DOI: 10.1194/Jlr.M029355 |
0.346 |
|
| 2012 |
Shah SH, Kraus WE, Newgard CB. Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function. Circulation. 126: 1110-20. PMID 22927473 DOI: 10.1161/Circulationaha.111.060368 |
0.337 |
|
| 2012 |
Ku BJ, Kim TH, Lee JH, Buras ED, White LD, Stevens RD, Ilkayeva OR, Bain JR, Newgard CB, DeMayo FJ, Jeong JW. Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis. Plos One. 7: e42915. PMID 22912762 DOI: 10.1371/Journal.Pone.0042915 |
0.311 |
|
| 2012 |
Stephens SB, Schisler JC, Hohmeier HE, An J, Sun AY, Pitt GS, Newgard CB. A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function. Cell Metabolism. 16: 33-43. PMID 22768837 DOI: 10.1016/J.Cmet.2012.05.011 |
0.434 |
|
| 2012 |
Kim DH, Sartor MA, Bain JR, Sandoval D, Stevens RD, Medvedovic M, Newgard CB, Woods SC, Seeley RJ. Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium. Diabetes. 61: 2299-310. PMID 22733798 DOI: 10.2337/Db11-1579 |
0.434 |
|
| 2012 |
Sampey BP, Freemerman AJ, Zhang J, Kuan PF, Galanko JA, O'Connell TM, Ilkayeva OR, Muehlbauer MJ, Stevens RD, Newgard CB, Brauer HA, Troester MA, Makowski L. Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. Plos One. 7: e38812. PMID 22701716 DOI: 10.1371/Journal.Pone.0038812 |
0.337 |
|
| 2012 |
Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM. Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. The Journal of Clinical Investigation. 122: 2428-38. PMID 22684107 DOI: 10.1172/Jci60580 |
0.349 |
|
| 2012 |
York B, Reineke EL, Sagen JV, Nikolai BC, Zhou S, Louet JF, Chopra AR, Chen X, Reed G, Noebels J, Adesina AM, Yu H, Wong LJ, Tsimelzon A, Hilsenbeck S, ... ... Newgard CB, et al. Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy. Cell Metabolism. 15: 752-63. PMID 22560224 DOI: 10.1016/J.Cmet.2012.03.020 |
0.419 |
|
| 2012 |
Newgard CB. Interplay between lipids and branched-chain amino acids in development of insulin resistance. Cell Metabolism. 15: 606-14. PMID 22560213 DOI: 10.1016/J.Cmet.2012.01.024 |
0.418 |
|
| 2012 |
Farese RV, Zechner R, Newgard CB, Walther TC. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance Cell Metabolism. 15: 570-573. PMID 22560209 DOI: 10.1016/J.Cmet.2012.03.004 |
0.336 |
|
| 2012 |
Huffman KM, Redman LM, Landerman LR, Pieper CF, Stevens RD, Muehlbauer MJ, Wenner BR, Bain JR, Kraus VB, Newgard CB, Ravussin E, Kraus WE. Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial. Plos One. 7: e28190. PMID 22523532 DOI: 10.1371/Journal.Pone.0028190 |
0.313 |
|
| 2012 |
Kimple ME, Moss JB, Brar HK, Rosa TC, Truchan NA, Pasker RL, Newgard CB, Casey PJ. Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. The Journal of Biological Chemistry. 287: 20344-55. PMID 22457354 DOI: 10.1074/Jbc.M112.359745 |
0.47 |
|
| 2012 |
Anderson KA, Lin F, Ribar TJ, Stevens RD, Muehlbauer MJ, Newgard CB, Means AR. Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse. Molecular Endocrinology (Baltimore, Md.). 26: 281-91. PMID 22240810 DOI: 10.1210/Me.2011-1299 |
0.456 |
|
| 2012 |
Shah SH, Crosslin DR, Haynes CS, Nelson S, Turer CB, Stevens RD, Muehlbauer MJ, Wenner BR, Bain JR, Laferrère B, Gorroochurn P, Teixeira J, Brantley PJ, Stevens VJ, Hollis JF, ... ... Newgard CB, et al. Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss. Diabetologia. 55: 321-30. PMID 22065088 DOI: 10.1007/S00125-011-2356-5 |
0.345 |
|
| 2012 |
Newgard CB. Finding mechanisms from metabolic signatures of disease Bmc Proceedings. 6: 1-1. DOI: 10.1186/1753-6561-6-S3-O19 |
0.417 |
|
| 2011 |
Brunner MP, Shah SH, Craig DM, Stevens RD, Muehlbauer MJ, Bain JR, Newgard CB, Kraus WE, Granger CB, Sketch MH, Newby LK. Effect of heparin administration on metabolomic profiles in samples obtained during cardiac catheterization. Circulation. Cardiovascular Genetics. 4: 695-700. PMID 22010138 DOI: 10.1161/Circgenetics.111.960575 |
0.324 |
|
| 2011 |
Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, StanÄáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, ... ... Newgard CB, et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Molecular Cell. 44: 177-90. PMID 21856199 DOI: 10.1016/J.Molcel.2011.07.019 |
0.369 |
|
| 2011 |
Monetti M, Levin MC, Watt MJ, Hubbard BK, Newgard C, Farese RV, Hevener AL, Farese RV. Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 108: E523; author reply E. PMID 21807991 DOI: 10.1073/Pnas.1108505108 |
0.414 |
|
| 2011 |
Laferrère B, Reilly D, Arias S, Swerdlow N, Gorroochurn P, Bawa B, Bose M, Teixeira J, Stevens RD, Wenner BR, Bain JR, Muehlbauer MJ, Haqq A, Lien L, Shah SH, ... ... Newgard CB, et al. Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss. Science Translational Medicine. 3: 80re2. PMID 21525399 DOI: 10.1126/Scitranslmed.3002043 |
0.414 |
|
| 2011 |
Sampey BP, Vanhoose AM, Winfield HM, Freemerman AJ, Muehlbauer MJ, Fueger PT, Newgard CB, Makowski L. Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Obesity (Silver Spring, Md.). 19: 1109-17. PMID 21331068 DOI: 10.1038/Oby.2011.18 |
0.357 |
|
| 2011 |
Redman LM, Huffman KM, Landerman LR, Pieper CF, Bain JR, Muehlbauer MJ, Stevens RD, Wenner BR, Kraus VB, Newgard CB, Kraus WE, Ravussin E. Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women. The Journal of Clinical Endocrinology and Metabolism. 96: E312-21. PMID 21123443 DOI: 10.1210/Jc.2010-1971 |
0.307 |
|
| 2011 |
Haqq AM, Muehlbauer MJ, Newgard CB, Grambow S, Freemark M. The metabolic phenotype of Prader-Willi syndrome (PWS) in childhood: heightened insulin sensitivity relative to body mass index. The Journal of Clinical Endocrinology and Metabolism. 96: E225-32. PMID 20962018 DOI: 10.1210/Jc.2010-1733 |
0.401 |
|
| 2011 |
Haqq A, Muehlbauer M, Newgard C, Svetkey L, Sharma A, Richer L, Mackenzie M, Mager D, Grambow S, Freemark M. Unique metabolic profile in children with Prader-Willi Syndrome: Heightened insulin sensitivity relative to body mass index Canadian Journal of Diabetes. 35: 145. DOI: 10.1016/S1499-2671(11)52031-3 |
0.366 |
|
| 2011 |
Newgard CB, Matschinsky FM. Substrate Control of Insulin Release Comprehensive Physiology. DOI: 10.1002/Cphy.Cp070205 |
0.52 |
|
| 2010 |
Louet JF, Chopra AR, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, Bain JR, Zhou S, DeMayo F, Xu J, Newgard CB, et al. The coactivator SRC-1 is an essential coordinator of hepatic glucose production. Cell Metabolism. 12: 606-18. PMID 21109193 DOI: 10.1016/J.Cmet.2010.11.009 |
0.436 |
|
| 2010 |
Civitarese AE, MacLean PS, Carling S, Kerr-Bayles L, McMillan RP, Pierce A, Becker TC, Moro C, Finlayson J, Lefort N, Newgard CB, Mandarino L, Cefalu W, Walder K, Collier GR, et al. Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL. Cell Metabolism. 11: 412-26. PMID 20444421 DOI: 10.1016/J.Cmet.2010.04.004 |
0.381 |
|
| 2010 |
Odegaard ML, Joseph JW, Jensen MV, Lu D, Ilkayeva O, Ronnebaum SM, Becker TC, Newgard CB. The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion. The Journal of Biological Chemistry. 285: 16530-7. PMID 20356834 DOI: 10.1074/Jbc.M109.092593 |
0.808 |
|
| 2010 |
Kelly P, Bailey CL, Fueger PT, Newgard CB, Casey PJ, Kimple ME. Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation. The Journal of Biological Chemistry. 285: 15777-85. PMID 20339002 DOI: 10.1074/Jbc.M109.069112 |
0.411 |
|
| 2010 |
Healy JA, Nilsson KR, Hohmeier HE, Berglund J, Davis J, Hoffman J, Kohler M, Li LS, Berggren PO, Newgard CB, Bennett V. Cholinergic augmentation of insulin release requires ankyrin-B. Science Signaling. 3: ra19. PMID 20234002 DOI: 10.1126/Scisignal.2000771 |
0.443 |
|
| 2010 |
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, ... Newgard CB, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 464: 121-5. PMID 20203611 DOI: 10.1038/Nature08778 |
0.358 |
|
| 2010 |
Wang MY, Chen L, Clark GO, Lee Y, Stevens RD, Ilkayeva OR, Wenner BR, Bain JR, Charron MJ, Newgard CB, Unger RH. Leptin therapy in insulin-deficient type I diabetes. Proceedings of the National Academy of Sciences of the United States of America. 107: 4813-9. PMID 20194735 DOI: 10.1073/Pnas.0909422107 |
0.452 |
|
| 2010 |
Lavine JA, Raess PW, Davis DB, Rabaglia ME, Presley BK, Keller MP, Beinfeld MC, Kopin AS, Newgard CB, Attie AD. Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note. Molecular Endocrinology (Baltimore, Md.). 24: 464-7. PMID 20081104 DOI: 10.1210/Me.2009-0384 |
0.31 |
|
| 2010 |
Tai ES, Tan ML, Stevens RD, Low YL, Muehlbauer MJ, Goh DL, Ilkayeva OR, Wenner BR, Bain JR, Lee JJ, Lim SC, Khoo CM, Shah SH, Newgard CB. Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men. Diabetologia. 53: 757-67. PMID 20076942 DOI: 10.1007/S00125-009-1637-8 |
0.402 |
|
| 2010 |
Maynard JC, Pham T, Zheng T, Jockheck-Clark A, Rankin HB, Newgard CB, Spana EP, Nicchitta CV. Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. Developmental Biology. 339: 295-306. PMID 20044986 DOI: 10.1016/J.Ydbio.2009.12.023 |
0.319 |
|
| 2010 |
Shah SH, Sun J, Pieper K, Haynes C, Muehlbauer M, Bain JR, Hauser ER, Kraus WE, Newgard CB, Granger CB, Califf RM, Newby LK. INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN (IGFBP) 2: A NOVEL METABOLIC BIOMARKER STRONGLY PREDICTIVE OF FUTURE CARDIOVASCULAR EVENTS Journal of the American College of Cardiology. 55: A97.E914. DOI: 10.1016/S0735-1097(10)60915-1 |
0.363 |
|
| 2009 |
Bain JR, Stevens RD, Wenner BR, Ilkayeva O, Muoio DM, Newgard CB. Metabolomics applied to diabetes research: moving from information to knowledge. Diabetes. 58: 2429-43. PMID 19875619 DOI: 10.2337/Db09-0580 |
0.377 |
|
| 2009 |
Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD. Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 18831-6. PMID 19850873 DOI: 10.1073/Pnas.0909731106 |
0.474 |
|
| 2009 |
Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L. Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. The Journal of Biological Chemistry. 284: 31236-48. PMID 19759004 DOI: 10.1074/Jbc.M109.048694 |
0.334 |
|
| 2009 |
Chao LC, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva OR, Ding SY, Reue K, Watt MJ, Newgard CB, Pilch PF, Hevener AL, Tontonoz P. Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes. 58: 2788-96. PMID 19741162 DOI: 10.2337/Db09-0763 |
0.474 |
|
| 2009 |
Huffman KM, Shah SH, Stevens RD, Bain JR, Muehlbauer M, Slentz CA, Tanner CJ, Kuchibhatla M, Houmard JA, Newgard CB, Kraus WE. Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. Diabetes Care. 32: 1678-83. PMID 19502541 DOI: 10.2337/Dc08-2075 |
0.492 |
|
| 2009 |
Rathmell JC, Newgard CB. Biochemistry. A glucose-to-gene link. Science (New York, N.Y.). 324: 1021-2. PMID 19460991 DOI: 10.1126/Science.1174665 |
0.425 |
|
| 2009 |
Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, Haqq AM, Shah SH, Arlotto M, Slentz CA, Rochon J, Gallup D, Ilkayeva O, Wenner BR, Yancy WS, et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metabolism. 9: 311-26. PMID 19356713 DOI: 10.1016/J.Cmet.2009.02.002 |
0.412 |
|
| 2009 |
Lien LF, Haqq AM, Arlotto M, Slentz CA, Muehlbauer MJ, McMahon RL, Rochon J, Gallup D, Bain JR, Ilkayeva O, Wenner BR, Stevens RD, Millington DS, Muoio DM, Butler MD, ... Newgard CB, et al. The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain. Omics : a Journal of Integrative Biology. 13: 21-35. PMID 19290809 DOI: 10.1089/Omi.2008.0035 |
0.332 |
|
| 2009 |
Malakauskas SM, Kourany WM, Zhang XY, Lu D, Stevens RD, Koves TR, Hohmeier HE, Muoio DM, Newgard CB, Le TH. Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha. Molecular Endocrinology (Baltimore, Md.). 23: 881-92. PMID 19246514 DOI: 10.1210/Me.2008-0274 |
0.483 |
|
| 2009 |
Moss LG, Newgard CB. The liver--a potential new player in islet regeneration? Cell Metabolism. 9: 5-6. PMID 19117540 DOI: 10.1016/J.Cmet.2008.12.009 |
0.376 |
|
| 2009 |
Wardell SE, Ilkayeva OR, Wieman HL, Frigo DE, Rathmell JC, Newgard CB, McDonnell DP. Glucose metabolism as a target of histone deacetylase inhibitors. Molecular Endocrinology (Baltimore, Md.). 23: 388-401. PMID 19106193 DOI: 10.1210/Jcem.94.2.9997 |
0.456 |
|
| 2009 |
Torres TP, Catlin RL, Chan R, Fujimoto Y, Sasaki N, Printz RL, Newgard CB, Shiota M. Restoration of Hepatic Glucokinase Expression Corrects Hepatic Glucose Flux and Normalizes Plasma Glucose in Zucker Diabetic Fatty Rats Diabetes. 58: 78-86. PMID 18952838 DOI: 10.2337/Db08-1119 |
0.4 |
|
| 2009 |
Malakauskas SM, Kourany WM, Zhang XY, Lu D, Stevens RD, Koves TR, Hohmeier HE, Muoio DM, Newgard CB, Le TH. Increased Insulin Sensitivity in Mice Lacking Collectrin, a Downstream Target of HNF-1α Endocrine Reviews. 30: 1837-1837. DOI: 10.1210/Edrv.30.3.9987 |
0.36 |
|
| 2008 |
Chopra AR, Louet JF, Saha P, An J, Demayo F, Xu J, York B, Karpen S, Finegold M, Moore D, Chan L, Newgard CB, O'Malley BW. Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science (New York, N.Y.). 322: 1395-9. PMID 19039140 DOI: 10.1126/Science.1164847 |
0.44 |
|
| 2008 |
Lavine JA, Raess PW, Davis DB, Rabaglia ME, Presley BK, Keller MP, Beinfeld MC, Kopin AS, Newgard CB, Attie AD. Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function. Molecular Endocrinology (Baltimore, Md.). 22: 2716-28. PMID 18845673 DOI: 10.1210/Me.2008-0255 |
0.426 |
|
| 2008 |
Ronnebaum SM, Jensen MV, Hohmeier HE, Burgess SC, Zhou YP, Qian S, MacNeil D, Howard A, Thornberry N, Ilkayeva O, Lu D, Sherry AD, Newgard CB. Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets. The Journal of Biological Chemistry. 283: 28909-17. PMID 18755687 DOI: 10.1074/Jbc.M804665200 |
0.807 |
|
| 2008 |
Jensen MV, Joseph JW, Ronnebaum SM, Burgess SC, Sherry AD, Newgard CB. Metabolic cycling in control of glucose-stimulated insulin secretion. American Journal of Physiology. Endocrinology and Metabolism. 295: E1287-97. PMID 18728221 DOI: 10.1152/Ajpendo.90604.2008 |
0.805 |
|
| 2008 |
Muoio DM, Newgard CB. Fatty acid oxidation and insulin action: when less is more. Diabetes. 57: 1455-6. PMID 18511446 DOI: 10.2337/Db08-0281 |
0.495 |
|
| 2008 |
Ronnebaum SM, Joseph JW, Ilkayeva O, Burgess SC, Lu D, Becker TC, Sherry AD, Newgard CB. Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism. The Journal of Biological Chemistry. 283: 14248-56. PMID 18381287 DOI: 10.1074/Jbc.M800119200 |
0.819 |
|
| 2008 |
Ferrara CT, Wang P, Neto EC, Stevens RD, Bain JR, Wenner BR, Ilkayeva OR, Keller MP, Blasiole DA, Kendziorski C, Yandell BS, Newgard CB, Attie AD. Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. Plos Genetics. 4: e1000034. PMID 18369453 DOI: 10.1371/Journal.Pgen.1000034 |
0.78 |
|
| 2008 |
Schisler JC, Fueger PT, Babu DA, Hohmeier HE, Tessem JS, Lu D, Becker TC, Naziruddin B, Levy M, Mirmira RG, Newgard CB. Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. Molecular and Cellular Biology. 28: 3465-76. PMID 18347054 DOI: 10.1128/Mcb.01791-07 |
0.735 |
|
| 2008 |
Fueger PT, Schisler JC, Lu D, Babu DA, Mirmira RG, Newgard CB, Hohmeier HE. Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function. Molecular Endocrinology (Baltimore, Md.). 22: 1251-9. PMID 18258687 DOI: 10.1210/Me.2007-0500 |
0.442 |
|
| 2008 |
Muoio DM, Newgard CB. Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nature Reviews. Molecular Cell Biology. 9: 193-205. PMID 18200017 DOI: 10.1038/Nrm2327 |
0.351 |
|
| 2008 |
Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD, Muoio DM. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metabolism. 7: 45-56. PMID 18177724 DOI: 10.1016/J.Cmet.2007.10.013 |
0.451 |
|
| 2008 |
Kimple ME, Joseph JW, Bailey CL, Fueger PT, Hendry IA, Newgard CB, Casey PJ. Galphaz negatively regulates insulin secretion and glucose clearance. The Journal of Biological Chemistry. 283: 4560-7. PMID 18096703 DOI: 10.1074/Jbc.M706481200 |
0.488 |
|
| 2007 |
Levin MC, Monetti M, Watt MJ, Sajan MP, Stevens RD, Bain JR, Newgard CB, Farese RV, Farese RV. Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. American Journal of Physiology. Endocrinology and Metabolism. 293: E1772-81. PMID 17940217 DOI: 10.1152/Ajpendo.00158.2007 |
0.424 |
|
| 2007 |
Joseph JW, Odegaard ML, Ronnebaum SM, Burgess SC, Muehlbauer J, Sherry AD, Newgard CB. Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion. The Journal of Biological Chemistry. 282: 31592-600. PMID 17823126 DOI: 10.1074/Jbc.M706080200 |
0.794 |
|
| 2007 |
Haqq AM, Muehlbauer M, Svetkey LP, Newgard CB, Purnell JQ, Grambow SC, Freemark MS. Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones. Clinical Endocrinology. 67: 944-51. PMID 17666087 DOI: 10.1111/J.1365-2265.2007.02991.X |
0.342 |
|
| 2007 |
Monetti M, Levin MC, Watt MJ, Sajan MP, Marmor S, Hubbard BK, Stevens RD, Bain JR, Newgard CB, Farese RV, Hevener AL, Farese RV. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metabolism. 6: 69-78. PMID 17618857 DOI: 10.1016/J.Cmet.2007.05.005 |
0.454 |
|
| 2007 |
Montori-Grau M, Guitart M, Lerin C, Andreu AL, Newgard CB, García-Martínez C, Gómez-Foix AM. Expression and glycogenic effect of glycogen-targeting protein phosphatase 1 regulatory subunit GL in cultured human muscle. Biochemical Journal. 405: 107-113. PMID 17555403 DOI: 10.1042/Bj20061572 |
0.478 |
|
| 2007 |
Nagle CA, An J, Shiota M, Torres TP, Cline GW, Liu ZX, Wang S, Catlin RL, Shulman GI, Newgard CB, Coleman RA. Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. The Journal of Biological Chemistry. 282: 14807-15. PMID 17389595 DOI: 10.1074/Jbc.M611550200 |
0.442 |
|
| 2007 |
Zhang YM, Chohnan S, Virga KG, Stevens RD, Ilkayeva OR, Wenner BR, Bain JR, Newgard CB, Lee RE, Rock CO, Jackowski S. Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis. Chemistry & Biology. 14: 291-302. PMID 17379144 DOI: 10.1016/J.Chembiol.2007.01.013 |
0.428 |
|
| 2007 |
Gleason CE, Lu D, Witters LA, Newgard CB, Birnbaum MJ. The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. The Journal of Biological Chemistry. 282: 10341-51. PMID 17287212 DOI: 10.1074/Jbc.M610631200 |
0.524 |
|
| 2007 |
Hardy OT, Hohmeier HE, Becker TC, Manduchi E, Doliba NM, Gupta RK, White P, Stoeckert CJ, Matschinsky FM, Newgard CB, Kaestner KH. Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents. Molecular Endocrinology (Baltimore, Md.). 21: 765-73. PMID 17185391 DOI: 10.1210/Me.2006-0411 |
0.484 |
|
| 2007 |
Pedersen KB, Zhang P, Doumen C, Charbonnet M, Lu D, Newgard CB, Haycock JW, Lange AJ, Scott DK. The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions. American Journal of Physiology. Endocrinology and Metabolism. 292: E788-801. PMID 17106062 DOI: 10.1152/Ajpendo.00510.2006 |
0.456 |
|
| 2007 |
Nagle CA, An J, Newgard CB, Coleman RA. Hepatic overexpression of glycerol‐sn‐3‐phosphate acyltransferase‐1 causes insulin resistance The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A699-B |
0.375 |
|
| 2006 |
Li LO, Mashek DG, An J, Doughman SD, Newgard CB, Coleman RA. Overexpression of rat long chain acyl-coa synthetase 1 alters fatty acid metabolism in rat primary hepatocytes. The Journal of Biological Chemistry. 281: 37246-55. PMID 17028193 DOI: 10.1074/Jbc.M604427200 |
0.375 |
|
| 2006 |
Joseph JW, Jensen MV, Ilkayeva O, Palmieri F, Alárcon C, Rhodes CJ, Newgard CB. The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion. The Journal of Biological Chemistry. 281: 35624-32. PMID 17001083 DOI: 10.1074/Jbc.M602606200 |
0.524 |
|
| 2006 |
Ronnebaum SM, Ilkayeva O, Burgess SC, Joseph JW, Lu D, Stevens RD, Becker TC, Sherry AD, Newgard CB, Jensen MV. A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion. The Journal of Biological Chemistry. 281: 30593-602. PMID 16912049 DOI: 10.1074/Jbc.M511908200 |
0.815 |
|
| 2006 |
Raum JC, Gerrish K, Artner I, Henderson E, Guo M, Sussel L, Schisler JC, Newgard CB, Stein R. FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Molecular and Cellular Biology. 26: 5735-43. PMID 16847327 DOI: 10.1128/Mcb.00249-06 |
0.32 |
|
| 2006 |
Qi L, Heredia JE, Altarejos JY, Screaton R, Goebel N, Niessen S, Macleod IX, Liew CW, Kulkarni RN, Bain J, Newgard C, Nelson M, Evans RM, Yates J, Montminy M. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science (New York, N.Y.). 312: 1763-6. PMID 16794074 DOI: 10.1126/Science.1123374 |
0.379 |
|
| 2006 |
Muoio DM, Newgard CB. Obesity-related derangements in metabolic regulation. Annual Review of Biochemistry. 75: 367-401. PMID 16756496 DOI: 10.1146/Annurev.Biochem.75.103004.142512 |
0.328 |
|
| 2006 |
Jensen MV, Joseph JW, Ilkayeva O, Burgess S, Lu D, Ronnebaum SM, Odegaard M, Becker TC, Sherry AD, Newgard CB. Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion. The Journal of Biological Chemistry. 281: 22342-51. PMID 16740637 DOI: 10.1074/Jbc.M604350200 |
0.796 |
|
| 2006 |
Chen S, Ding JH, Bekeredjian R, Yang BZ, Shohet RV, Johnston SA, Hohmeier HE, Newgard CB, Grayburn PA. Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology. Proceedings of the National Academy of Sciences of the United States of America. 103: 8469-74. PMID 16709667 DOI: 10.1073/Pnas.0602921103 |
0.442 |
|
| 2006 |
Collier JJ, Fueger PT, Hohmeier HE, Newgard CB. Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines. Diabetes. 55: 1398-406. PMID 16644697 DOI: 10.2337/Db05-1000 |
0.341 |
|
| 2005 |
Haqq AM, Lien LF, Boan J, Arlotto M, Slentz CA, Muehlbauer MJ, Rochon J, Gallup D, McMahon RL, Bain JR, Stevens R, Millington D, Butler MD, Newgard CB, Svetkey LP. The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design. Contemporary Clinical Trials. 26: 616-25. PMID 16239128 DOI: 10.1016/J.Cct.2005.09.003 |
0.322 |
|
| 2005 |
Koves TR, Li P, An J, Akimoto T, Slentz D, Ilkayeva O, Dohm GL, Yan Z, Newgard CB, Muoio DM. Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. The Journal of Biological Chemistry. 280: 33588-98. PMID 16079133 DOI: 10.1074/Jbc.M507621200 |
0.358 |
|
| 2005 |
Muoio DM, Newgard CB. Metabolism: A is for adipokine. Nature. 436: 337-8. PMID 16034406 DOI: 10.1038/436337A |
0.36 |
|
| 2005 |
Samli KN, McGuire MJ, Newgard CB, Johnston SA, Brown KC. Peptide-mediated targeting of the islets of langerhans Diabetes. 54: 2103-2108. PMID 15983211 DOI: 10.2337/Diabetes.54.7.2103 |
0.349 |
|
| 2005 |
Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB. The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells Proceedings of the National Academy of Sciences of the United States of America. 102: 7297-7302. PMID 15883383 DOI: 10.1073/Pnas.0502168102 |
0.461 |
|
| 2005 |
Iype T, Francis J, Garmey JC, Schisler JC, Nesher R, Weir GC, Becker TC, Newgard CB, Griffen SC, Mirmira RG. Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: Application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes Journal of Biological Chemistry. 280: 16798-16807. PMID 15743769 DOI: 10.1074/Jbc.M414381200 |
0.419 |
|
| 2005 |
Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB, Spiegelman BM. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell. 120: 261-73. PMID 15680331 DOI: 10.1016/J.Cell.2004.11.043 |
0.333 |
|
| 2004 |
Hohmeier HE, Newgard CB. Cell lines derived from pancreatic islets Molecular and Cellular Endocrinology. 228: 121-128. PMID 15541576 DOI: 10.1016/J.Mce.2004.04.017 |
0.378 |
|
| 2004 |
Muoio DM, Newgard CB. Biomedicine. Insulin resistance takes a trip through the ER. Science (New York, N.Y.). 306: 425-6. PMID 15486283 DOI: 10.1126/Science.1104680 |
0.396 |
|
| 2004 |
Bain JR, Schisler JC, Takeuchi K, Newgard CB, Becker TC. An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans. Diabetes. 53: 2190-4. PMID 15331526 DOI: 10.2337/Diabetes.53.9.2190 |
0.358 |
|
| 2004 |
Newgard CB, Hohmeier HE, Lu D, Jensen MV, Tran VV, Chen G, Burgess S, Sherry AD. Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies Cell Biochemistry and Biophysics. 40: 159-168. PMID 15289651 DOI: 10.1385/Cbb:40:3:159 |
0.389 |
|
| 2004 |
Boucher A, Lu D, Burgess SC, Telemaque-Potts S, Jensen MV, Mulder H, Wang MY, Unger RH, Sherry AD, Newgard CB. Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue. The Journal of Biological Chemistry. 279: 27263-71. PMID 15073188 DOI: 10.1074/Jbc.M401167200 |
0.518 |
|
| 2004 |
An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, Koves TR, Stevens R, Millington D, Newgard CB. Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance Nature Medicine. 10: 268-274. PMID 14770177 DOI: 10.1038/Nm995 |
0.427 |
|
| 2003 |
Hohmeier HE, Tran VV, Chen G, Gasa R, Newgard CB. Inflammatory mechanisms in diabetes: lessons from the beta-cell. International Journal of Obesity. 27. PMID 14704737 DOI: 10.1038/Sj.Ijo.0802493 |
0.31 |
|
| 2003 |
Ramanadham S, Song H, Hsu FF, Zhang S, Crankshaw M, Grant GA, Newgard CB, Bao S, Ma Z, Turk J. Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript. Biochemistry. 42: 13929-40. PMID 14636061 DOI: 10.1021/Bi034843P |
0.38 |
|
| 2003 |
Lerín C, Montell E, Nolasco T, Clark C, Brady MJ, Newgard CB, Gómez-Foix AM. Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content. Diabetes. 52: 2221-2226. PMID 12941760 DOI: 10.2337/Diabetes.52.9.2221 |
0.313 |
|
| 2003 |
Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Developmental Cell. 5: 73-83. PMID 12852853 DOI: 10.1016/S1534-5807(03)00170-9 |
0.486 |
|
| 2003 |
Lin J, Tarr PT, Yang R, Rhee J, Puigserver P, Newgard CB, Spiegelman BM. PGC-1beta in the regulation of hepatic glucose and energy metabolism. The Journal of Biological Chemistry. 278: 30843-8. PMID 12807885 DOI: 10.1074/Jbc.M303643200 |
0.368 |
|
| 2003 |
Tran VV, Chen G, Newgard CB, Hohmeier HE. Discrete and Complementary Mechanisms of Protection of β-Cells Against Cytokine-Induced and Oxidative Damage Achieved by bcl-2 Overexpression and a Cytokine Selection Strategy Diabetes. 52: 1423-1432. PMID 12765953 DOI: 10.2337/Diabetes.52.6.1423 |
0.344 |
|
| 2003 |
St-Pierre J, Lin J, Krauss S, Tarr PT, Yang R, Newgard CB, Spiegelman BM. Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. The Journal of Biological Chemistry. 278: 26597-603. PMID 12734177 DOI: 10.1074/Jbc.M301850200 |
0.319 |
|
| 2003 |
Yang R, Newgard CB. Hepatic expression of a targeting subunit of protein phosphatase-1 in streptozotocin-diabetic rats reverses hyperglycemia and hyperphagia despite depressed glucokinase expression. The Journal of Biological Chemistry. 278: 23418-25. PMID 12697773 DOI: 10.1074/Jbc.M213112200 |
0.442 |
|
| 2002 |
Newgard CB, Lu D, Jensen MV, Schissler J, Boucher A, Burgess S, Sherry AD. Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: Insights gained from a multidisciplinary approach Diabetes. 51: S389-S393. PMID 12475781 DOI: 10.2337/Diabetes.51.2007.S389 |
0.496 |
|
| 2002 |
Newgard CB. While Tinkering With the β-Cell… Metabolic Regulatory Mechanisms and New Therapeutic Strategies: American Diabetes Association Lilly Lecture, 2001 Diabetes. 51: 3141-3150. PMID 12401704 DOI: 10.2337/Diabetes.51.11.3141 |
0.39 |
|
| 2002 |
Guan HP, Li Y, Jensen MV, Newgard CB, Steppan CM, Lazar MA. A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nature Medicine. 8: 1122-8. PMID 12357248 DOI: 10.1038/Nm780 |
0.472 |
|
| 2002 |
Lu D, Mulder H, Zhao P, Burgess SC, Jensen MV, Kamzolova S, Newgard CB, Sherry AD. 13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS). Proceedings of the National Academy of Sciences of the United States of America. 99: 2708-13. PMID 11880625 DOI: 10.1073/Pnas.052005699 |
0.522 |
|
| 2002 |
Antinozzi PA, Ishihara H, Newgard CB, Wollheim CB. Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues. The Journal of Biological Chemistry. 277: 11746-55. PMID 11821387 DOI: 10.1074/Jbc.M108462200 |
0.478 |
|
| 2002 |
n JCJ, Telemaque-Potts S, s A, Anderson P, Newgard CB, mez-Foix AMG. Glucokinase gene transfer to skeletal muscle of diabetic Zucker fatty rats improves insulin-sensitive glucose uptake Metabolism-Clinical and Experimental. 51: 121-126. PMID 11782883 DOI: 10.1053/Meta.2002.29028 |
0.485 |
|
| 2002 |
Wu C, Okar DA, Newgard CB, Lange AJ. Increasing fructose 2,6-bisphosphate overcomes hepatic insulin resistance of type 2 diabetes. American Journal of Physiology. Endocrinology and Metabolism. 282: E38-45. PMID 11739081 DOI: 10.1152/Ajpendo.2002.282.1.E38 |
0.462 |
|
| 2002 |
Montell E, Lerı́n C, Newgard CB, Gómez-Foix AM. Effects of Modulation of Glycerol Kinase Expression on Lipid and Carbohydrate Metabolism in Human Muscle Cells Journal of Biological Chemistry. 277: 2682-2686. PMID 11714702 DOI: 10.1074/Jbc.M107227200 |
0.358 |
|
| 2002 |
Gasa R, Clark C, Yang R, DePaoli-Roach AA, Newgard CB. Reversal of diet-induced glucose intolerance by hepatic expression of a variant glycogen-targeting subunit of protein phosphatase-1. The Journal of Biological Chemistry. 277: 1524-30. PMID 11707447 DOI: 10.1074/Jbc.M107744200 |
0.37 |
|
| 2002 |
Yang R, Cao L, Gasa R, Brady MJ, Sherry AD, Newgard CB. Glycogen-targeting subunits and glucokinase differentially affect pathways of glycogen metabolism and their regulation in hepatocytes. The Journal of Biological Chemistry. 277: 1514-23. PMID 11600496 DOI: 10.1074/Jbc.M107001200 |
0.422 |
|
| 2001 |
Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 413: 131-8. PMID 11557972 DOI: 10.1038/35093050 |
0.462 |
|
| 2001 |
Sonenberg N, Newgard CB. Protein synthesis. The perks of balancing glucose. Science (New York, N.Y.). 293: 818-9. PMID 11486079 DOI: 10.1126/Science.1062937 |
0.474 |
|
| 2001 |
An J, Li Y, van De Werve G, Newgard CB. Overexpression of the P46 (T1) translocase component of the glucose-6-phosphatase complex in hepatocytes impairs glycogen accumulation via hydrolysis of glucose 1-phosphate. The Journal of Biological Chemistry. 276: 10722-9. PMID 11148207 DOI: 10.1074/Jbc.M009525200 |
0.428 |
|
| 2001 |
Wu C, Okar DA, Newgard CB, Lange AJ. Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production. Journal of Clinical Investigation. 107: 91-98. PMID 11134184 DOI: 10.1172/Jci11103 |
0.428 |
|
| 2001 |
Mulder H, Lu D, Finley IV J, An J, Cohen J, Antinozzi PA, McGarry JD, Newgard CB. Overexpression of a Modified Human Malonyl-CoA Decarboxylase Blocks the Glucose-induced Increase in Malonyl-CoA Level but Has No Impact on Insulin Secretion in INS-1-derived (832/13) β-Cells Journal of Biological Chemistry. 276: 6479-6484. PMID 11113153 DOI: 10.1074/Jbc.M010364200 |
0.704 |
|
| 2001 |
Chen G, Hohmeier HE, Newgard CB. Expression of the Transcription Factor STAT-1α in Insulinoma Cells Protects against Cytotoxic Effects of Multiple Cytokines Journal of Biological Chemistry. 276: 766-772. PMID 11024034 DOI: 10.1074/Jbc.M008330200 |
0.348 |
|
| 2001 |
Jensen PB, Knop FK, Chen G, Hohmeier HE, Mulder H, Newgard CB. Identification of genes involved in glucose-stimulated insulin secretion Diabetes. 50. DOI: 10.2337/Diabetes.50.2007.S134 |
0.485 |
|
| 2000 |
Newgard CB, Brady MJ, O'Doherty RM, Saltiel AR. Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1. Diabetes. 49: 1967-77. PMID 11117996 DOI: 10.2337/Diabetes.49.12.1967 |
0.485 |
|
| 2000 |
Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Burke TR, Quon MJ, Reed BC, Dikic I, Noel LE, Newgard CB, Farese R. Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter. The Journal of Biological Chemistry. 275: 40817-26. PMID 11007796 DOI: 10.1074/Jbc.M007920200 |
0.437 |
|
| 2000 |
Lerı́n C, Montell E, Berman HK, Newgard CB, Gómez-Foix AM. Overexpression of protein targeting to glycogen in cultured human muscle cells stimulates glycogen synthesis independent of glycogen and glucose 6-phosphate levels. Journal of Biological Chemistry. 275: 39991-39995. PMID 10998419 DOI: 10.1074/Jbc.M006251200 |
0.466 |
|
| 2000 |
Roduit R, Morin J, Massé F, Segall L, Roche E, Newgard CB, Assimacopoulos-Jeannet F, Prentki M. Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell. The Journal of Biological Chemistry. 275: 35799-806. PMID 10967113 DOI: 10.1074/Jbc.M006001200 |
0.523 |
|
| 2000 |
Chen G, Hohmeier HE, Gasa R, Tran VV, Newgard CB. Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity. Diabetes. 49: 562-570. PMID 10871193 DOI: 10.2337/Diabetes.49.4.562 |
0.327 |
|
| 2000 |
Hohmeier HE, Mulder H, Chen G, Henkel-Rieger R, Prentki M, Newgard CB. Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion Diabetes. 49: 424-430. PMID 10868964 DOI: 10.2337/Diabetes.49.3.424 |
0.482 |
|
| 2000 |
Gasa R, Jensen PB, Berman HK, Brady MJ, Depaoli-Roach AA, Newgard CB. Distinctive regulatory and metabolic properties of glycogen-targeting subunits of protein phosphatase-1 (PTG, G(L), G(M)/R(G1)) expressed in hepatocytes Journal of Biological Chemistry. 275: 26396-26403. PMID 10862764 DOI: 10.1074/Jbc.M002427200 |
0.357 |
|
| 2000 |
Werve GVD, Lange AJ, Newgard C, Méchin MC, Li Y, Berteloot A. New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. Febs Journal. 267: 1533-1549. PMID 10712583 DOI: 10.1046/J.1432-1327.2000.01160.X |
0.451 |
|
| 2000 |
Buettner R, Newgard CB, Rhodes CJ, O'Doherty RM. Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia American Journal of Physiology-Endocrinology and Metabolism. 278. PMID 10710512 DOI: 10.1152/Ajpendo.2000.278.3.E563 |
0.421 |
|
| 2000 |
O’Doherty RM, Jensen PB, Anderson P, Jones JG, Berman HK, Kearney D, Newgard CB. Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen Journal of Clinical Investigation. 105: 479-488. PMID 10683377 DOI: 10.1172/Jci8673 |
0.493 |
|
| 2000 |
Newgard CB, Mulder H, Gasa R, Jensen PB, Potts ST, Sherry D. Metabolic regulatory mechanisms in liver and pancreatic islets revealed by genetic engineering Biochemical Society Transactions. 28. DOI: 10.1042/Bst028A099B |
0.32 |
|
| 1999 |
Jiménez-Chillarón JC, Newgard CB, Gómez-Foix AM. Increased glucose disposal induced by adenovirus-mediated transfer of glucokinase to skeletal muscle in vivo. The Faseb Journal. 13: 2153-2160. PMID 10593862 DOI: 10.1096/Fasebj.13.15.2153 |
0.476 |
|
| 1999 |
Seoane J, Barberà A, Télémaque-Potts S, Newgard CB, Guinovart JJ. Glucokinase Overexpression Restores Glucose Utilization and Storage in Cultured Hepatocytes from Male Zucker Diabetic Fatty Rats Journal of Biological Chemistry. 274: 31833-31838. PMID 10542207 DOI: 10.1074/Jbc.274.45.31833 |
0.46 |
|
| 1999 |
O'Doherty RM, Lehman DL, Télémaque-Potts S, Newgard CB. Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia. Diabetes. 48: 2022-2027. PMID 10512368 DOI: 10.2337/Diabetes.48.10.2022 |
0.483 |
|
| 1999 |
O’Doherty RM, Anderson PR, Zhao AZ, Bornfeldt KE, Newgard CB. Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition. American Journal of Physiology-Endocrinology and Metabolism. 277. PMID 10484368 DOI: 10.1152/Ajpendo.1999.277.3.E544 |
0.317 |
|
| 1999 |
Aiston S, Trinh KY, Lange AJ, Newgard CB, Agius L. Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase. Journal of Biological Chemistry. 274: 24559-24566. PMID 10455119 DOI: 10.1074/Jbc.274.35.24559 |
0.466 |
|
| 1999 |
Antinozzi PA, Berman HK, O'Doherty RM, Newgard CB. Metabolic engineering with recombinant adenoviruses Annual Review of Nutrition. 19: 511-544. PMID 10448535 DOI: 10.1146/Annurev.Nutr.19.1.511 |
0.456 |
|
| 1999 |
Gaisano HY, Huang X, Sheu L, Ghai M, Newgard CB, Trinh KY, Trimble WS. Snare protein expression and adenoviral transfection of amphicrine AR42J Biochemical and Biophysical Research Communications. 260: 781-784. PMID 10403842 DOI: 10.1006/Bbrc.1999.0987 |
0.302 |
|
| 1999 |
Seijffers R, Ben-David O, Cohen Y, Karasik A, Berezin M, Newgard CB, Ferber S. Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells. Endocrinology. 140: 3311-7. PMID 10385428 DOI: 10.1210/Endo.140.7.6796 |
0.468 |
|
| 1999 |
Gasa R, Trinh KY, Yu K, Wilkie TM, Newgard CB. Overexpression of G11alpha and isoforms of phospholipase C in islet beta-cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion. Diabetes. 48: 1035-1044. PMID 10331408 DOI: 10.2337/Diabetes.48.5.1035 |
0.447 |
|
| 1999 |
Wang MY, Shimabukuro M, Lee Y, Trinh KY, Chen JL, Newgard CB, Unger RH. Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves β- cell function Diabetes. 48: 1020-1025. PMID 10331406 DOI: 10.2337/Diabetes.48.5.1020 |
0.494 |
|
| 1999 |
Zhou YT, Wang ZW, Higa M, Newgard CB, Unger RH. Reversing adipocyte differentiation: Implications for treatment of obesity Proceedings of the National Academy of Sciences of the United States of America. 96: 2391-2395. PMID 10051652 DOI: 10.1073/Pnas.96.5.2391 |
0.359 |
|
| 1998 |
Shimabukuro M, Higa M, Zhou YT, Wang MY, Newgard CB, Unger RH. Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression Journal of Biological Chemistry. 273: 32487-32490. PMID 9829981 DOI: 10.1074/Jbc.273.49.32487 |
0.368 |
|
| 1998 |
Trinh KY, O’Doherty RM, Anderson P, Lange AJ, Newgard CB. Perturbation of Fuel Homeostasis Caused by Overexpression of the Glucose-6-phosphatase Catalytic Subunit in Liver of Normal Rats Journal of Biological Chemistry. 273: 31615-31620. PMID 9813078 DOI: 10.1074/Jbc.273.47.31615 |
0.503 |
|
| 1998 |
Berman HK, O’Doherty RM, Anderson P, Newgard CB. Overexpression of Protein Targeting to Glycogen (PTG) in Rat Hepatocytes Causes Profound Activation of Glycogen Synthesis Independent of Normal Hormone- and Substrate-mediated Regulatory Mechanisms Journal of Biological Chemistry. 273: 26421-26425. PMID 9756875 DOI: 10.1074/Jbc.273.41.26421 |
0.417 |
|
| 1998 |
Wang MY, Koyama K, Shimabukuro M, Mangelsdorf D, Newgard CB, Unger RH. Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose- stimulated insulin secretion Proceedings of the National Academy of Sciences of the United States of America. 95: 11921-11926. PMID 9751766 DOI: 10.1073/Pnas.95.20.11921 |
0.47 |
|
| 1998 |
Scott DK, O'Doherty RM, Stafford JM, Newgard CB, Granner DK. The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism. The Journal of Biological Chemistry. 273: 24145-51. PMID 9727036 DOI: 10.1074/Jbc.273.37.24145 |
0.484 |
|
| 1998 |
Baqué S, Montell E, Guinovart JJ, Newgard CB, Gómez-Foix AM. Expression of glucokinase in cultured human muscle cells confers insulin-independent and glucose concentration-dependent increases in glucose disposal and storage. Diabetes. 47: 1392-1398. PMID 9726226 DOI: 10.2337/Diabetes.47.9.1392 |
0.499 |
|
| 1998 |
Koyama K, Shimabukuro M, Chen G, Wang MY, Lee Y, Kalra PS, Dube MG, Kalra SP, Newgard CB, Unger RH. Resistance to adenovirally induced hyperleptinemia in rats: Comparison of ventromedial hypothalamic lesions and mutated leptin receptors Journal of Clinical Investigation. 102: 728-733. PMID 9710441 DOI: 10.1172/Jci3353 |
0.34 |
|
| 1998 |
Shimabukuro M, Wang MY, Zhou YT, Newgard CB, Unger RH. Protection against lipoapoptosis of β cells through leptin-dependent maintenance of Bcl-2 expression Proceedings of the National Academy of Sciences of the United States of America. 95: 9558-9561. PMID 9689119 DOI: 10.1073/Pnas.95.16.9558 |
0.396 |
|
| 1998 |
Zhou YT, Shimabukuro M, Wang MY, Lee Y, Higa M, Milburn JL, Newgard CB, Unger RH. Role of peroxisome proliferator-activated receptor α in disease of pancreatic β cells Proceedings of the National Academy of Sciences of the United States of America. 95: 8898-8903. PMID 9671776 DOI: 10.1073/Pnas.95.15.8898 |
0.369 |
|
| 1998 |
Antinozzi PA, Segall L, Prentki M, McGarry JD, Newgard CB. Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis. The Journal of Biological Chemistry. 273: 16146-54. PMID 9632669 DOI: 10.1074/jbc.273.26.16146 |
0.698 |
|
| 1998 |
Hohmeier H-, Thigpen A, Tran VV, Davis R, Newgard CB. Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production. Journal of Clinical Investigation. 101: 1811-1820. PMID 9576743 DOI: 10.1172/Jci1489 |
0.372 |
|
| 1998 |
Berman HK, Newgard CB. Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression. Biochemistry. 37: 4543-4552. PMID 9521775 DOI: 10.1021/Bi9726133 |
0.502 |
|
| 1998 |
Wang MY, Koyama K, Shimabukuro M, Newgard CB, Uncer RH. OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype Proceedings of the National Academy of Sciences of the United States of America. 95: 714-718. PMID 9435258 DOI: 10.1073/Pnas.95.2.714 |
0.379 |
|
| 1997 |
Seoane J, Trinh K, O’Doherty RM, Gómez-Foix AM, Lange AJ, Newgard CB, Guinovart JJ. Metabolic Impact Of Adenovirus-Mediated Overexpression Of The Glucose-6-Phosphatase Catalytic Subunit In Hepatocytes Journal of Biological Chemistry. 272: 26972-26977. PMID 9341134 DOI: 10.1074/Jbc.272.43.26972 |
0.51 |
|
| 1997 |
Trinh K, Minassian C, Lange AJ, O’Doherty RM, Newgard CB. Adenovirus-mediated Expression of the Catalytic Subunit of Glucose-6-phosphatase in INS-1 Cells EFFECTS ON GLUCOSE CYCLING, GLUCOSE USAGE, AND INSULIN SECRETION Journal of Biological Chemistry. 272: 24837-24842. PMID 9312082 DOI: 10.1074/Jbc.272.40.24837 |
0.534 |
|
| 1997 |
Newgard CB, Clark S, BeltrandelRio H, Hohmeier HE, Quaade C, Normington K. Engineered cell lines for insulin replacement in diabetes: current status and future prospects Diabetologia. 40. PMID 9248700 DOI: 10.1007/S001250051398 |
0.442 |
|
| 1997 |
Koyama K, Chen G, Wang MY, Lee Y, Shimabukuro M, Newgard CB, Unger RH. β-Cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy Diabetes. 46: 1276-1280. PMID 9231651 DOI: 10.2337/Diab.46.8.1276 |
0.465 |
|
| 1997 |
Noel RJ, Antinozzi PA, McGarry JD, Newgard CB. Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling Journal of Biological Chemistry. 272: 18621-18627. PMID 9228030 DOI: 10.1074/jbc.272.30.18621 |
0.694 |
|
| 1997 |
Zhou YT, Shimabukuro M, Koyama K, Lee Y, Wang MY, Trieu F, Newgard CB, Unger RH. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation Proceedings of the National Academy of Sciences of the United States of America. 94: 6386-6390. PMID 9177227 DOI: 10.1073/Pnas.94.12.6386 |
0.398 |
|
| 1997 |
Hohmeier HE, BeltrandelRio H, Clark SA, Henkel-Rieger R, Normington K, Newgard CB. Regulation of insulin secretion from novel engineered insulinoma cell lines. Diabetes. 46: 968-77. PMID 9166667 DOI: 10.2337/Diab.46.6.968 |
0.501 |
|
| 1997 |
Clark SA, Quaade C, Constandy H, Hansen P, Halban P, Ferber S, Newgard CB, Normington K. Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression. Diabetes. 46: 958-67. PMID 9166666 DOI: 10.2337/Diab.46.6.958 |
0.405 |
|
| 1997 |
Noel LE, Newgard CB. Structural Domains That Contribute to Substrate Specificity in Facilitated Glucose Transporters Are Distinct from Those Involved in Kinetic Function: Studies with GLUT-1/GLUT-2 Chimeras† Biochemistry. 36: 5465-5475. PMID 9154929 DOI: 10.1021/Bi9630624 |
0.375 |
|
| 1997 |
Argaud D, Kirby TL, Newgard CB, Lange AJ. Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate. The Journal of Biological Chemistry. 272: 12854-61. PMID 9139747 DOI: 10.1074/Jbc.272.19.12854 |
0.485 |
|
| 1997 |
Shimabukuro M, Koyama K, Chen G, Wang MY, Trieu F, Lee Y, Newgard CB, Unger RH. Direct antidiabetic effect of leptin through triglyceride depletion of tissues Proceedings of the National Academy of Sciences of the United States of America. 94: 4637-4641. PMID 9114043 DOI: 10.1073/Pnas.94.9.4637 |
0.423 |
|
| 1997 |
Newgard CB, Becker TC, Berman HK, O'Doherty RM. Regulation of overexpressed hexokinases in liver and islet cells Biochemical Society Transactions. 25: 118-122. PMID 9056855 DOI: 10.1042/Bst0250118 |
0.334 |
|
| 1996 |
Chen G, Koyama K, Yuan X, Lee YH, Zhou YT, O'Doherty R, Newgard CB, Unger RH. Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy Proceedings of the National Academy of Sciences of the United States of America. 93: 14795-14799. PMID 8962134 DOI: 10.1073/Pnas.93.25.14795 |
0.368 |
|
| 1996 |
Agius L, Peak M, Newgard CB, Gomez-Foix AM, Guinovart JJ. Evidence for a role of glucose-induced translocation of glucokinase in the control of hepatic glycogen synthesis Journal of Biological Chemistry. 271: 30479-30486. PMID 8940014 DOI: 10.1074/Jbc.271.48.30479 |
0.439 |
|
| 1996 |
Seoane J, Gómez-Foix AM, O'Doherty RM, Gómez-Ara C, Newgard CB, Guinovart JJ. Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase. The Journal of Biological Chemistry. 271: 23756-60. PMID 8798601 DOI: 10.1074/Jbc.271.39.23756 |
0.461 |
|
| 1996 |
O'Doherty RM, Lehman DL, Seoane J, Gómez-Foix AM, Guinovart JJ, Newgard CB. Differential metabolic effects of adenovirus-mediated glucokinase and hexokinase I overexpression in rat primary hepatocytes. The Journal of Biological Chemistry. 271: 20524-30. PMID 8702794 DOI: 10.1074/Jbc.271.34.20524 |
0.503 |
|
| 1996 |
Becker TC, Noel RJ, Johnson JH, Lynch RM, Hirose H, Tokuyama Y, Bell GI, Newgard CB. Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes. The Journal of Biological Chemistry. 271: 390-4. PMID 8550593 DOI: 10.1074/Jbc.271.1.390 |
0.544 |
|
| 1996 |
Schnedl WJ, Hohmeier HE, Newgard CB. Insulinsezernierende Zellen zur Therapie des Diabetes mellitus Naturwissenschaften. 83: 1-5. DOI: 10.1007/Bf01139303 |
0.442 |
|
| 1995 |
Milburn JL, Hirose H, Lee YH, Nagasawa Y, Ogawa A, Ohneda M, BeltrandelRio H, Newgard CB, Johnson JH, Unger RH. Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids. The Journal of Biological Chemistry. 270: 1295-9. PMID 7836394 DOI: 10.1074/Jbc.270.3.1295 |
0.498 |
|
| 1995 |
Argaud D, Lange AJ, Becker TC, Okar DA, El-Maghrabi MR, Newgard CB, Pilkis SJ. Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells: Paradoxical effect on Fru-2,6-P2 levels Journal of Biological Chemistry. 270: 24229-24236. PMID 7592629 DOI: 10.1074/Jbc.270.41.24229 |
0.364 |
|
| 1995 |
Newgard CB, McGarry JD. Metabolic coupling factors in pancreatic beta-cell signal transduction. Annual Review of Biochemistry. 64: 689-719. PMID 7574498 DOI: 10.1146/annurev.bi.64.070195.003353 |
0.7 |
|
| 1994 |
Newgard CB. Cellular Engineering and Gene Therapy Strategies for Insulin Replacement in Diabetes Diabetes. 43: 341-350. PMID 8314006 DOI: 10.2337/Diab.43.3.341 |
0.443 |
|
| 1994 |
Schnedl WJ, Ferber S, Johnson JH, Newgard CB. STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. Diabetes. 43: 1326-33. PMID 7926307 DOI: 10.2337/Diab.43.11.1326 |
0.425 |
|
| 1994 |
Becker TC, Noel RJ, Coats WS, Gómez-Foix AM, Alam T, Gerard RD, Newgard CB. Use of recombinant adenovirus for metabolic engineering of mammalian cells Methods in Cell Biology. 43: 161-189. PMID 7823861 DOI: 10.1016/S0091-679X(08)60603-2 |
0.308 |
|
| 1994 |
Baqué S, Newgard CB, Gerard RD, Guinovart JJ, Gómez-Foix AM. Adenovirus-mediated delivery into myocytes of muscle glycogen phosphorylase, the enzyme deficient in patients with glycogen-storage disease type V. Biochemical Journal. 304: 1009-1014. PMID 7818463 DOI: 10.1042/Bj3041009 |
0.311 |
|
| 1993 |
Inman LR, McAllister CT, Chen L, Hughes S, Newgard CB, Kettman JR, Unger RH, Johnson JH. Autoantibodies to the GLUT-2 glucose transporter of beta cells in insulin-dependent diabetes mellitus of recent onset. Proceedings of the National Academy of Sciences of the United States of America. 90: 1281-4. PMID 8433987 DOI: 10.1073/Pnas.90.4.1281 |
0.473 |
|
| 1993 |
Hughes S, Quaade C, Johnson J, Ferber S, Newgard C. Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism Journal of Biological Chemistry. 268: 15205-15212. DOI: 10.1016/s0021-9258(18)82457-7 |
0.421 |
|
| 1992 |
Chen L, Appel MC, Alam T, Miyaura C, Sestak A, O’Neil J, Unger RH, Newgard CB. Factors regulating islet regeneration in the post-insulinoma NEDH rat. Advances in Experimental Medicine and Biology. 321: 71-84. PMID 1449084 DOI: 10.1007/978-1-4615-3448-8_9 |
0.352 |
|
| 1992 |
Hughes SD, Johnson JH, Quaade C, Newgard CB. Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells. Proceedings of the National Academy of Sciences of the United States of America. 89: 688-692. PMID 1309953 DOI: 10.1073/Pnas.89.2.688 |
0.515 |
|
| 1991 |
Miyaura C, Chen L, Appel M, Alam T, Inman L, Hughes SD, Milburn JL, Unger RH, Newgard CB. Expression of reg/PSP, a Pancreatic Exocrine Gene: Relationship to Changes in Islet β-Cell Mass Molecular Endocrinology. 5: 226-234. PMID 2038344 DOI: 10.1210/Mend-5-2-226 |
0.311 |
|
| 1991 |
Quaade C, Hughes SD, Coats WS, Sestak AL, Iynedjian PB, Newgard CB. Analysis of the protein products encoded by variant glucokinase transcripts via expression in bacteria Febs Letters. 280: 47-52. PMID 2009966 DOI: 10.1016/0014-5793(91)80201-D |
0.36 |
|
| 1990 |
Orci L, Ravazzola M, Baetens D, Inman L, Amherdt M, Peterson RG, Newgard CB, Johnson JH, Unger RH. Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia. Proceedings of the National Academy of Sciences of the United States of America. 87: 9953-9957. PMID 2263645 DOI: 10.1073/Pnas.87.24.9953 |
0.468 |
|
| 1990 |
Johnson JH, Ogawa A, Chen L, Orci L, Newgard CB, Alam T, Unger RH. Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes Science. 250: 546-549. PMID 2237405 DOI: 10.1126/SCIENCE.250.4985.1195-B |
0.494 |
|
| 1990 |
Chen L, Alam T, Johnson JH, Hughes S, Newgard CB, Unger RH. Regulation of beta-cell glucose transporter gene expression. Proceedings of the National Academy of Sciences of the United States of America. 87: 4088-4092. PMID 2190214 DOI: 10.1073/Pnas.87.11.4088 |
0.47 |
|
| 1990 |
Newgard CB, Quaade C, Hughes SD, Milburn JL. Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homoeostasis. Biochemical Society Transactions. 18: 851-853. PMID 2083694 DOI: 10.1042/Bst0180851 |
0.521 |
|
| 1989 |
Iynedjian PB, Pilot P, Nouspikel T, Milburn JL, Quaade C, Hughes S, Ucla C, Newgard CB. Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans. Proceedings of the National Academy of Sciences of the United States of America. 86: 7838-7842. PMID 2682629 DOI: 10.1073/Pnas.86.20.7838 |
0.373 |
|
| 1989 |
Leffert JD, Newgard CB, Okamoto H, Milburn JL, Luskey KL. Rat amylin: cloning and tissue-specific expression in pancreatic islets. Proceedings of the National Academy of Sciences of the United States of America. 86: 3127-3130. PMID 2654937 DOI: 10.1073/Pnas.86.9.3127 |
0.303 |
|
| 1987 |
Rath VL, Newgard CB, Sprang SR, Goldsmith EJ, Fletterick RJ. Modeling the biochemical differences between rabbit muscle and human liver phosphorylase. Proteins. 2: 225-35. PMID 3447179 DOI: 10.1002/Prot.340020307 |
0.3 |
|
| 1987 |
McGarry JD, Kuwajima M, Newgard CB, Foster DW, Katz J. From dietary glucose to liver glycogen: the full circle round. Annual Review of Nutrition. 7: 51-73. PMID 3038155 DOI: 10.1146/Annurev.Nu.07.070187.000411 |
0.677 |
|
| 1984 |
Newgard CB, Moore SV, Foster DW, McGarry JD. Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway. The Journal of Biological Chemistry. 259: 6958-63. PMID 6725277 |
0.646 |
|
| 1984 |
Kuwajima M, Newgard CB, Foster DW, McGarry JD. Time course and significance of changes in hepatic fructose-2,6-bisphosphate levels during refeeding of fasted rats. The Journal of Clinical Investigation. 74: 1108-11. PMID 6547962 DOI: 10.1172/Jci111479 |
0.598 |
|
| 1984 |
Newgard CB, Foster DW, McGarry JD. Evidence for suppression of hepatic glucose-6-phosphatase with carbohydrate feeding. Diabetes. 33: 192-5. PMID 6319214 DOI: 10.2337/Diab.33.2.192 |
0.674 |
|
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