| Year |
Citation |
Score |
| 2024 |
Moon SJ, Chiappino-Pepe A, Dong W, Kelleher JK, Vander Heiden M, Stephanopoulos G, Sikes HD. NADPH composite index analysis quantifies the relationship between compartmentalized NADPH dynamics and growth rates in cancer cells. Biorxiv : the Preprint Server For Biology. PMID 38746234 DOI: 10.1101/2024.04.27.591477 |
0.745 |
|
| 2024 |
Ma Y, Shang Y, Stephanopoulos G. Engineering peroxisomal biosynthetic pathways for maximization of triterpene production in . Proceedings of the National Academy of Sciences of the United States of America. 121: e2314798121. PMID 38261612 DOI: 10.1073/pnas.2314798121 |
0.321 |
|
| 2022 |
Ma Y, Zu Y, Huang S, Stephanopoulos G. Engineering a universal and efficient platform for terpenoid synthesis in yeast. Proceedings of the National Academy of Sciences of the United States of America. 120: e2207680120. PMID 36577077 DOI: 10.1073/pnas.2207680120 |
0.318 |
|
| 2022 |
Ma Y, Liu N, Greisen P, Li J, Qiao K, Huang S, Stephanopoulos G. Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica. Nature Communications. 13: 572. PMID 35102143 DOI: 10.1038/s41467-022-28277-w |
0.577 |
|
| 2021 |
Keibler MA, Dong W, Korthauer KD, Hosios AM, Moon SJ, Sullivan LB, Liu N, Abbott KL, Arevalo OD, Ho K, Lee J, Phanse AS, Kelleher JK, Iliopoulos O, Coloff JL, ... ... Stephanopoulos G, et al. Differential Substrate Use in EGF- and Oncogenic KRAS-Stimulated Human Mammary Epithelial Cells. The Febs Journal. PMID 33811729 DOI: 10.1111/febs.15858 |
0.305 |
|
| 2021 |
Santala S, Santala V, Liu N, Stephanopoulos G. Partitioning metabolism between growth and product synthesis for coordinated production of wax esters in Acinetobacter baylyi ADP1. Biotechnology and Bioengineering. PMID 33666232 DOI: 10.1002/bit.27740 |
0.334 |
|
| 2020 |
Zu Y, Prather KL, Stephanopoulos G. Metabolic engineering strategies to overcome precursor limitations in isoprenoid biosynthesis. Current Opinion in Biotechnology. 66: 171-178. PMID 32853882 DOI: 10.1016/J.Copbio.2020.07.005 |
0.432 |
|
| 2020 |
Luo Z, Liu N, Lazar Z, Chatzivasileiou A, Ward V, Chen J, Zhou J, Stephanopoulos G. Enhancing isoprenoid synthesis in Yarrowia lipolytica by expressing the isopentenol utilization pathway and modulating intracellular hydrophobicity. Metabolic Engineering. PMID 32758537 DOI: 10.1016/J.Ymben.2020.07.010 |
0.4 |
|
| 2020 |
Abdel-Mawgoud AM, Stephanopoulos G. Improving CRISPR/Cas9-mediated genome editing efficiency in Yarrowia lipolytica using direct tRNA-sgRNA fusions. Metabolic Engineering. 62: 106-115. PMID 32758536 DOI: 10.1016/J.Ymben.2020.07.008 |
0.308 |
|
| 2020 |
Daletos G, Stephanopoulos G. Protein engineering strategies for microbial production of isoprenoids. Metabolic Engineering Communications. 11: e00129. PMID 32612930 DOI: 10.1016/J.Mec.2020.E00129 |
0.381 |
|
| 2020 |
Yusuf R, Saez B, Sharda A, van Gastel N, Yu V, Baryawno N, Scadden EW, Acharya SS, Chattophadhyay S, Huang C, Viswanathan V, S'aulis D, Cobert J, Sykes DB, Keibler MA, ... ... Stephanopoulos G, et al. Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers. Blood. PMID 32458004 DOI: 10.1182/Blood.2019001808 |
0.344 |
|
| 2020 |
Daletos G, Katsimpouras C, Stephanopoulos G. Novel Strategies and Platforms for Industrial Isoprenoid Engineering. Trends in Biotechnology. PMID 32359971 DOI: 10.1016/J.Tibtech.2020.03.009 |
0.425 |
|
| 2020 |
Liu Y, Low ZJ, Ma X, Liang H, Stephanopoulos G, Sinskey AJ, Zhou K. Using biopolymer bodies for encapsulation of hydrophobic products in bacterium. Metabolic Engineering. PMID 32339760 DOI: 10.1016/J.Ymben.2020.04.006 |
0.322 |
|
| 2020 |
Dong W, Moon SJ, Kelleher JK, Stephanopoulos G. Dissecting mammalian cell metabolism through 13C- and 2H-isotope tracing: Interpretations at the molecular and systems levels Industrial & Engineering Chemistry Research. 59: 2593-2610. DOI: 10.1021/Acs.Iecr.9B05154 |
0.391 |
|
| 2019 |
Park JO, Liu N, Holinski KM, Emerson DF, Qiao K, Woolston BM, Xu J, Lazar Z, Islam MA, Vidoudez C, Girguis PR, Stephanopoulos G. Synergistic substrate cofeeding stimulates reductive metabolism. Nature Metabolism. 1: 643-651. PMID 32694804 DOI: 10.1038/s42255-019-0077-0 |
0.585 |
|
| 2019 |
Kuroda K, Hammer SK, Watanabe Y, Montaño López J, Fink GR, Stephanopoulos G, Ueda M, Avalos JL. Critical Roles of the Pentose Phosphate Pathway and GLN3 in Isobutanol-Specific Tolerance in Yeast. Cell Systems. PMID 31734159 DOI: 10.1016/J.Cels.2019.10.006 |
0.398 |
|
| 2019 |
Mano J, Liu N, Hammond JH, Currie DH, Stephanopoulos G. Engineering Yarrowia lipolytica for the utilization of acid whey. Metabolic Engineering. PMID 31562926 DOI: 10.1016/J.Ymben.2019.09.010 |
0.364 |
|
| 2019 |
Liu N, Santala S, Stephanopoulos G. Mixed carbon substrates: a necessary nuisance or a missed opportunity? Current Opinion in Biotechnology. 62: 15-21. PMID 31513988 DOI: 10.1016/J.Copbio.2019.07.003 |
0.384 |
|
| 2019 |
Ward VCA, Chatzivasileiou AO, Stephanopoulos G. Cell free biosynthesis of isoprenoids from isopentenol. Biotechnology and Bioengineering. PMID 31429926 DOI: 10.1002/Bit.27146 |
0.446 |
|
| 2019 |
Cheng F, Yu H, Stephanopoulos G. Engineering Corynebacterium glutamicum for high-titer biosynthesis of hyaluronic acid. Metabolic Engineering. PMID 31301358 DOI: 10.1016/J.Ymben.2019.07.003 |
0.415 |
|
| 2019 |
Emerson DF, Stephanopoulos G. Limitations in converting waste gases to fuels and chemicals. Current Opinion in Biotechnology. 59: 39-45. PMID 30856509 DOI: 10.1016/J.Copbio.2019.02.004 |
0.347 |
|
| 2019 |
Vasdekis AE, Alanazi H, Silverman AM, Williams CJ, Canul AJ, Cliff JB, Dohnalkova AC, Stephanopoulos G. Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging. Nature Communications. 10: 848. PMID 30783105 DOI: 10.1038/S41467-019-08717-W |
0.392 |
|
| 2019 |
Chatzivasileiou AO, Ward V, Edgar SM, Stephanopoulos G. Two-step pathway for isoprenoid synthesis. Proceedings of the National Academy of Sciences of the United States of America. 116: 506-511. PMID 30584096 DOI: 10.1073/Pnas.1812935116 |
0.421 |
|
| 2019 |
Man C, Scadden DT, Mercier F, Liu N, Dong W, Stephanopoulos G, Jiang L, Jung Y, Lin C, Leung AY. Epigenetic Activation of the pH Regulator MCT4 in Acute Myeloid Leukemia Exploits a Fundamental Metabolic Process of Enhancing Cell Growth through Proton Shifting Blood. 134: 3765-3765. DOI: 10.1182/Blood-2019-123604 |
0.365 |
|
| 2019 |
Park JO, Liu N, Holinski KM, Emerson DF, Qiao K, Woolston BM, Xu J, Lazar Z, Islam MA, Vidoudez C, Girguis PR, Stephanopoulos G. Synergistic substrate cofeeding stimulates reductive metabolism Nature Metabolism. 1: 643-651. DOI: 10.1038/s42255-019-0077-0 |
0.534 |
|
| 2018 |
Uranukul B, Woolston BM, Fink GR, Stephanopoulos G. Biosynthesis of monoethylene glycol in Saccharomyces cerevisiae utilizing native glycolytic enzymes. Metabolic Engineering. 51: 20-31. PMID 30268818 DOI: 10.1016/J.Ymben.2018.09.012 |
0.43 |
|
| 2018 |
Abdel-Mawgoud AM, Markham KA, Palmer CM, Liu N, Stephanopoulos G, Alper HS. Metabolic engineering in the host Yarrowia lipolytica. Metabolic Engineering. PMID 30056205 DOI: 10.1016/J.Ymben.2018.07.016 |
0.448 |
|
| 2018 |
Lazar Z, Liu N, Stephanopoulos G. Holistic Approaches in Lipid Production by Yarrowia lipolytica. Trends in Biotechnology. PMID 30006239 DOI: 10.1016/J.Tibtech.2018.06.007 |
0.407 |
|
| 2018 |
Abdel-Mawgoud AM, Stephanopoulos G. Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering. Synthetic and Systems Biotechnology. 3: 3-19. PMID 29911195 DOI: 10.1016/J.Synbio.2017.12.001 |
0.395 |
|
| 2018 |
Woolston BM, Emerson DF, Currie DH, Stephanopoulos G. Rediverting carbon flux in Clostridium ljungdahlii using CRISPR Interference (CRISPRi). Metabolic Engineering. PMID 29906505 DOI: 10.1016/j.ymben.2018.06.006 |
0.303 |
|
| 2018 |
Li ZJ, Hong PH, Da YY, Li LK, Stephanopoulos G. Metabolic engineering of Escherichia coli for the production of L-malate from xylose. Metabolic Engineering. PMID 29800611 DOI: 10.1016/J.Ymben.2018.05.010 |
0.36 |
|
| 2018 |
Ward VCA, Chatzivasileiou AO, Stephanopoulos G. Metabolic engineering of Escherichia coli for the production of isoprenoids. Fems Microbiology Letters. 365. PMID 29718190 DOI: 10.1093/Femsle/Fny079 |
0.444 |
|
| 2018 |
Marlow JJ, Kumar A, Enalls B, Reynard LM, Tuross N, Stephanopoulos G, Girguis P. Harnessing a Methane-Fueled, Sediment-Free Mixed Microbial Community for Utilization of Distributed Sources of Natural Gas. Biotechnology and Bioengineering. PMID 29460958 DOI: 10.1002/Bit.26576 |
0.343 |
|
| 2017 |
Hung YP, Teragawa C, Kosaisawe N, Gillies TE, Pargett M, Minguet M, Distor K, Rocha-Gregg BL, Coloff JL, Keibler MA, Stephanopoulos G, Yellen G, Brugge JS, Albeck JG. Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells. Elife. 6. PMID 29239720 DOI: 10.7554/Elife.27293 |
0.377 |
|
| 2017 |
Li ZJ, Qiao K, Che XM, Stephanopoulos G. Metabolic engineering of Escherichia coli for the synthesis of the quadripolymer poly(glycolate-co-lactate-co-3-hydroxybutyrate-co-4-hydroxybutyrate) from glucose. Metabolic Engineering. PMID 28916461 DOI: 10.1016/J.Ymben.2017.09.003 |
0.607 |
|
| 2017 |
Cheng F, Luozhong S, Guo Z, Yu H, Stephanopoulos G. Enhanced biosynthesis of hyaluronic acid using engineered Corynebacterium glutamicum via metabolic pathway regulation. Biotechnology Journal. PMID 28869338 DOI: 10.1002/Biot.201700191 |
0.423 |
|
| 2017 |
Xu J, Liu N, Qiao K, Vogg S, Stephanopoulos G. Application of metabolic controls for the maximization of lipid production in semicontinuous fermentation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28630295 DOI: 10.1073/Pnas.1703321114 |
0.605 |
|
| 2017 |
Ahsanul Islam M, Hadadi N, Ataman M, Hatzimanikatis V, Stephanopoulos G. Exploring Biochemical Pathways for Mono-Ethylene Glycol (MEG) Synthesis from Synthesis Gas. Metabolic Engineering. PMID 28433737 DOI: 10.1016/J.Ymben.2017.04.005 |
0.403 |
|
| 2017 |
King JR, Woolston BM, Stephanopoulos G. Designing a new entry point into isoprenoid metabolism by exploiting fructose-6-phosphate aldolase side-reactivity of Escherichia coli. Acs Synthetic Biology. PMID 28375628 DOI: 10.1021/Acssynbio.7B00072 |
0.448 |
|
| 2017 |
Okazaki A, Gameiro PA, Christodoulou D, Laviollette L, Schneider M, Chaves F, Stemmer-Rachamimov A, Yazinski SA, Lee R, Stephanopoulos G, Zou L, Iliopoulos O. Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers. The Journal of Clinical Investigation. PMID 28346230 DOI: 10.1172/Jci87800 |
0.354 |
|
| 2017 |
Xu P, Qiao K, Stephanopoulos G. Engineering oxidative stress defense pathways to build a robust lipid production platform in Yarrowia lipolytica. Biotechnology and Bioengineering. PMID 28295166 DOI: 10.1002/Bit.26285 |
0.63 |
|
| 2017 |
Dong W, Keibler MA, Stephanopoulos G. Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis. Metabolic Engineering. PMID 28192215 DOI: 10.1016/J.Ymben.2017.02.002 |
0.38 |
|
| 2017 |
Qiao K, Wasylenko TM, Zhou K, Xu P, Stephanopoulos G. Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism. Nature Biotechnology. PMID 28092657 DOI: 10.1038/Nbt.3763 |
0.623 |
|
| 2017 |
Vasdekis AE, Silverman AM, Stephanopoulos G. Exploiting Bioprocessing Fluctuations to Elicit the Mechanistics of De Novo Lipogenesis in Yarrowia lipolytica. Plos One. 12: e0168889. PMID 28052085 DOI: 10.1371/Journal.Pone.0168889 |
0.343 |
|
| 2016 |
Berrios C, Padi M, Keibler MA, Park DE, Molla V, Cheng J, Lee SM, Stephanopoulos G, Quackenbush J, DeCaprio JA. Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. Plos Pathogens. 12: e1006020. PMID 27880818 DOI: 10.1371/Journal.Ppat.1006020 |
0.33 |
|
| 2016 |
Li ZJ, Qiao K, Liu N, Stephanopoulos G. Engineering Yarrowia lipolytica for poly-3-hydroxybutyrate production. Journal of Industrial Microbiology & Biotechnology. PMID 27826725 DOI: 10.1007/S10295-016-1864-1 |
0.573 |
|
| 2016 |
Edgar S, Li FS, Qiao K, Weng JK, Stephanopoulos G. Engineering of Taxadiene Synthase for Improved Selectivity and Yield of a Key Taxol Biosynthetic Intermediate. Acs Synthetic Biology. PMID 27794603 DOI: 10.1021/Acssynbio.6B00206 |
0.594 |
|
| 2016 |
Xu P, Qiao K, Ahn WS, Stephanopoulos G. Engineering Yarrowia lipolytica as a platform for synthesis of drop-in transportation fuels and oleochemicals. Proceedings of the National Academy of Sciences of the United States of America. PMID 27621436 DOI: 10.1073/Pnas.1607295113 |
0.597 |
|
| 2016 |
Keibler MA, Wasylenko TM, Kelleher JK, Iliopoulos O, Vander Heiden MG, Stephanopoulos G. Metabolic requirements for cancer cell proliferation. Cancer & Metabolism. 4: 16. PMID 27540483 DOI: 10.1186/S40170-016-0156-6 |
0.368 |
|
| 2016 |
Shaw AJ, Lam FH, Hamilton M, Consiglio A, MacEwen K, Brevnova EE, Greenhagen E, LaTouf WG, South CR, van Dijken H, Stephanopoulos G. Metabolic engineering of microbial competitive advantage for industrial fermentation processes. Science (New York, N.Y.). 353: 583-6. PMID 27493184 DOI: 10.1126/Science.Aaf6159 |
0.387 |
|
| 2016 |
Xu P, Rizzoni EA, Sul SY, Stephanopoulos G. Improving metabolic pathway efficiency by statistical model based multivariate regulatory metabolic engineering (MRME). Acs Synthetic Biology. PMID 27490704 DOI: 10.1021/Acssynbio.6B00187 |
0.455 |
|
| 2016 |
Zhou K, Edgar S, Stephanopoulos G. Engineering Microbes to Synthesize Plant Isoprenoids. Methods in Enzymology. 575: 225-45. PMID 27417931 DOI: 10.1016/Bs.Mie.2016.03.007 |
0.359 |
|
| 2016 |
Liu N, Qiao K, Stephanopoulos G. (13)C Metabolic Flux Analysis of acetate conversion to lipids by Yarrowia lipolytica. Metabolic Engineering. PMID 27387605 DOI: 10.1016/J.Ymben.2016.06.006 |
0.635 |
|
| 2016 |
Zhang H, Stephanopoulos G. Co-culture engineering for microbial biosynthesis of 3-amino-benzoic acid in Escherichia coli. Biotechnology Journal. PMID 27168529 DOI: 10.1002/Biot.201600013 |
0.405 |
|
| 2016 |
King JR, Edgar S, Qiao K, Stephanopoulos G. Accessing Nature's diversity through metabolic engineering and synthetic biology. F1000research. 5. PMID 27081481 DOI: 10.12688/F1000Research.7311.1 |
0.629 |
|
| 2016 |
Friedlander J, Tsakraklides V, Kamineni A, Greenhagen EH, Consiglio AL, MacEwen K, Crabtree DV, Afshar J, Nugent RL, Hamilton MA, Joe Shaw A, South CR, Stephanopoulos G, Brevnova EE. Engineering of a high lipid producing Yarrowia lipolytica strain. Biotechnology For Biofuels. 9: 77. PMID 27034715 DOI: 10.1186/S13068-016-0492-3 |
0.384 |
|
| 2016 |
Biggs BW, Lim CG, Sagliani K, Shankar S, Stephanopoulos G, De Mey M, Ajikumar PK. Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. PMID 26951651 DOI: 10.1073/Pnas.1515826113 |
0.39 |
|
| 2016 |
Hu P, Chakraborty S, Kumar A, Woolston B, Liu H, Emerson D, Stephanopoulos G. Integrated bioprocess for conversion of gaseous substrates to liquids. Proceedings of the National Academy of Sciences of the United States of America. PMID 26951649 DOI: 10.1073/Pnas.1516867113 |
0.348 |
|
| 2016 |
Silverman AM, Qiao K, Xu P, Stephanopoulos G. Functional overexpression and characterization of lipogenesis-related genes in the oleaginous yeast Yarrowia lipolytica. Applied Microbiology and Biotechnology. PMID 26915993 DOI: 10.1007/S00253-016-7376-0 |
0.616 |
|
| 2016 |
Zhang C, Chen X, Stephanopoulos G, Too HP. Efflux transporter engineering markedly improves amorphadiene production in Escherichia coli. Biotechnology and Bioengineering. PMID 26804325 DOI: 10.1002/Bit.25943 |
0.33 |
|
| 2016 |
Li ZJ, Qiao K, Shi W, Pereira B, Zhang H, Olsen BD, Stephanopoulos G. Biosynthesis of poly(glycolate-co-lactate-co-3-hydroxybutyrate) from glucose by metabolically engineered Escherichia coli. Metabolic Engineering. PMID 26778413 DOI: 10.1016/J.Ymben.2016.01.004 |
0.622 |
|
| 2015 |
Pereira B, Li ZJ, De Mey M, Giaw Lim C, Zhang H, Hoeltgen C, Stephanopoulos G. Efficient utilization of pentoses for bioproduction of the renewable two-carbon compounds ethylene glycol and glycolate. Metabolic Engineering. PMID 26711083 DOI: 10.1016/J.Ymben.2015.12.004 |
0.345 |
|
| 2015 |
Cheng F, Gong Q, Yu H, Stephanopoulos G. High-titer biosynthesis of hyaluronic acid by recombinant Corynebacterium glutamicum. Biotechnology Journal. PMID 26709615 DOI: 10.1002/Biot.201500404 |
0.357 |
|
| 2015 |
Edgar S, Zhou K, Qiao K, King JR, Simpson JH, Stephanopoulos G. Mechanistic Insights into Taxadiene Epoxidation by Taxadiene-5α-Hydroxylase. Acs Chemical Biology. PMID 26677870 DOI: 10.1021/Acschembio.5B00767 |
0.567 |
|
| 2015 |
Vasdekis AE, Silverman AM, Stephanopoulos G. Origins of Cell-to-Cell Bioprocessing Diversity and Implications of the Extracellular Environment Revealed at the Single-Cell Level. Scientific Reports. 5: 17689. PMID 26657999 DOI: 10.1038/Srep17689 |
0.379 |
|
| 2015 |
Zhang H, Li Z, Pereira B, Stephanopoulos G. Engineering E. coli-E. coli cocultures for production of muconic acid from glycerol. Microbial Cell Factories. 14: 134. PMID 26369810 DOI: 10.1186/S12934-015-0319-0 |
0.328 |
|
| 2015 |
Pereira B, Zhang H, De Mey M, Lim CG, Li ZJ, Stephanopoulos G. Engineering a novel biosynthetic pathway in Escherichia coli for production of renewable ethylene glycol. Biotechnology and Bioengineering. PMID 26221864 DOI: 10.1002/Bit.25717 |
0.415 |
|
| 2015 |
Tsakraklides V, Brevnova E, Stephanopoulos G, Shaw AJ. Improved Gene Targeting through Cell Cycle Synchronization. Plos One. 10: e0133434. PMID 26192309 DOI: 10.1371/Journal.Pone.0133434 |
0.321 |
|
| 2015 |
Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 524: 361-5. PMID 26168401 DOI: 10.1038/Nature14587 |
0.386 |
|
| 2015 |
Zhang H, Pereira B, Li Z, Stephanopoulos G. Engineering Escherichia coli coculture systems for the production of biochemical products. Proceedings of the National Academy of Sciences of the United States of America. PMID 26111796 DOI: 10.1073/Pnas.1506781112 |
0.403 |
|
| 2015 |
Islam MA, Zengler K, Edwards EA, Mahadevan R, Stephanopoulos G. Investigating Moorella thermoacetica metabolism with a genome-scale constraint-based metabolic model. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 25994252 DOI: 10.1039/C5Ib00095E |
0.606 |
|
| 2015 |
Wasylenko TM, Ahn WS, Stephanopoulos G. The oxidative pentose phosphate pathway is the primary source of NADPH for lipid overproduction from glucose in Yarrowia lipolytica. Metabolic Engineering. 30: 27-39. PMID 25747307 DOI: 10.1016/J.Ymben.2015.02.007 |
0.424 |
|
| 2015 |
Qiao K, Imam Abidi SH, Liu H, Zhang H, Chakraborty S, Watson N, Kumaran Ajikumar P, Stephanopoulos G. Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica. Metabolic Engineering. 29: 56-65. PMID 25732624 DOI: 10.1016/J.Ymben.2015.02.005 |
0.619 |
|
| 2015 |
Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, ... ... Stephanopoulos G, et al. A roadmap for interpreting (13)C metabolite labeling patterns from cells. Current Opinion in Biotechnology. 34: 189-201. PMID 25731751 DOI: 10.1016/J.Copbio.2015.02.003 |
0.643 |
|
| 2015 |
Zhou K, Qiao K, Edgar S, Stephanopoulos G. Distributing a metabolic pathway among a microbial consortium enhances production of natural products. Nature Biotechnology. 33: 377-83. PMID 25558867 DOI: 10.1038/Nbt.3095 |
0.595 |
|
| 2015 |
Vasdekis AE, Stephanopoulos G. Review of methods to probe single cell metabolism and bioenergetics. Metabolic Engineering. 27: 115-35. PMID 25448400 DOI: 10.1016/J.Ymben.2014.09.007 |
0.386 |
|
| 2015 |
Wasylenko TM, Stephanopoulos G. Metabolomic and (13)C-metabolic flux analysis of a xylose-consuming Saccharomyces cerevisiae strain expressing xylose isomerase. Biotechnology and Bioengineering. 112: 470-83. PMID 25311863 DOI: 10.1002/Bit.25447 |
0.412 |
|
| 2015 |
Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, Haas W, et al. Abstract NG08: Transcriptional mechanisms for autophagy regulation and metabolic reprogramming in pancreatic cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Ng08 |
0.402 |
|
| 2015 |
Okazaki A, Gameiro P, Stephanopoulos G, Iliopoulos O. Abstract 1123: Glutaminase inhibitors suppress pyrimidine synthesis and promote DNA replication stress inVHL-deficient human renal cancer cells Cancer Research. 75: 1123-1123. DOI: 10.1158/1538-7445.Am2015-1123 |
0.307 |
|
| 2015 |
Vasdekis AE, Stephanopoulos G. Mapping Bioprocessing Dynamics and Noise at the Single Cell Level using Microfluidics Biophysical Journal. 108: 149a. DOI: 10.1016/J.Bpj.2014.11.820 |
0.367 |
|
| 2014 |
Lam FH, Ghaderi A, Fink GR, Stephanopoulos G. Biofuels. Engineering alcohol tolerance in yeast. Science (New York, N.Y.). 346: 71-5. PMID 25278607 DOI: 10.1126/Science.1257859 |
0.311 |
|
| 2014 |
Xu P, Li L, Zhang F, Stephanopoulos G, Koffas M. Improving fatty acids production by engineering dynamic pathway regulation and metabolic control. Proceedings of the National Academy of Sciences of the United States of America. 111: 11299-304. PMID 25049420 DOI: 10.1073/Pnas.1406401111 |
0.691 |
|
| 2014 |
Zhang J, Ahn WS, Gameiro PA, Keibler MA, Zhang Z, Stephanopoulos G. 13C isotope-assisted methods for quantifying glutamine metabolism in cancer cells. Methods in Enzymology. 542: 369-89. PMID 24862276 DOI: 10.1016/B978-0-12-416618-9.00019-4 |
0.408 |
|
| 2014 |
Yadav VG, Stephanopoulos G. Metabolic engineering: the ultimate paradigm for continuous pharmaceutical manufacturing. Chemsuschem. 7: 1847-53. PMID 24719301 DOI: 10.1002/Cssc.201301219 |
0.366 |
|
| 2014 |
Wang BL, Ghaderi A, Zhou H, Agresti J, Weitz DA, Fink GR, Stephanopoulos G. Microfluidic high-throughput culturing of single cells for selection based on extracellular metabolite production or consumption. Nature Biotechnology. 32: 473-8. PMID 24705516 DOI: 10.1038/Nbt.2857 |
0.408 |
|
| 2014 |
Keibler M, Wasylenko T, Kelleher J, Stephanopoulos G. Quantifying the demand for central carbon metabolism precursors for biosynthesis in proliferating cells Cancer & Metabolism. 2. DOI: 10.1186/2049-3002-2-S1-P35 |
0.45 |
|
| 2014 |
Nicolay BN, Danielian PS, Haas W, Stephanopoulos G, Lees JA, Dyson NJ. Metabolic analysis of the loss of Rb1 in vivo Cancer & Metabolism. 2. DOI: 10.1186/2049-3002-2-S1-O4 |
0.388 |
|
| 2013 |
Zou R, Zhou K, Stephanopoulos G, Too HP. Combinatorial engineering of 1-deoxy-D-xylulose 5-phosphate pathway using cross-lapping in vitro assembly (CLIVA) method. Plos One. 8: e79557. PMID 24223968 DOI: 10.1371/Journal.Pone.0079557 |
0.372 |
|
| 2013 |
Zhang C, Chen X, Zou R, Zhou K, Stephanopoulos G, Too HP. Combining genotype improvement and statistical media optimization for isoprenoid production in E. coli. Plos One. 8: e75164. PMID 24124471 DOI: 10.1371/Journal.Pone.0075164 |
0.395 |
|
| 2013 |
Wasylenko TM, Stephanopoulos G. Kinetic isotope effects significantly influence intracellular metabolite (13) C labeling patterns and flux determination. Biotechnology Journal. 8: 1080-9. PMID 23828762 DOI: 10.1002/Biot.201200276 |
0.349 |
|
| 2013 |
Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, et al. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 153: 840-54. PMID 23663782 DOI: 10.1016/J.Cell.2013.04.023 |
0.384 |
|
| 2013 |
Carlsen S, Ajikumar PK, Formenti LR, Zhou K, Phon TH, Nielsen ML, Lantz AE, Kielland-Brandt MC, Stephanopoulos G. Heterologous expression and characterization of bacterial 2-C-methyl-D-erythritol-4-phosphate pathway in Saccharomyces cerevisiae. Applied Microbiology and Biotechnology. 97: 5753-69. PMID 23636690 DOI: 10.1007/S00253-013-4877-Y |
0.359 |
|
| 2013 |
Woolston BM, Edgar S, Stephanopoulos G. Metabolic engineering: past and future. Annual Review of Chemical and Biomolecular Engineering. 4: 259-88. PMID 23540289 DOI: 10.1146/Annurev-Chembioeng-061312-103312 |
0.408 |
|
| 2013 |
Gameiro PA, Laviolette LA, Kelleher JK, Iliopoulos O, Stephanopoulos G. Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle. The Journal of Biological Chemistry. 288: 12967-77. PMID 23504317 DOI: 10.1074/Jbc.M112.396796 |
0.35 |
|
| 2013 |
Gameiro PA, Yang J, Metelo AM, Pérez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O. In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation. Cell Metabolism. 17: 372-85. PMID 23473032 DOI: 10.1016/J.Cmet.2013.02.002 |
0.306 |
|
| 2013 |
Avalos JL, Fink GR, Stephanopoulos G. Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols. Nature Biotechnology. 31: 335-41. PMID 23417095 DOI: 10.1038/Nbt.2509 |
0.415 |
|
| 2013 |
Nicolay BN, Gameiro PA, Tschöp K, Korenjak M, Heilmann AM, Asara JM, Stephanopoulos G, Iliopoulos O, Dyson NJ. Loss of RBF1 changes glutamine catabolism. Genes & Development. 27: 182-96. PMID 23322302 DOI: 10.1101/Gad.206227.112 |
0.363 |
|
| 2013 |
Zhang H, Stephanopoulos G. Engineering E. coli for caffeic acid biosynthesis from renewable sugars. Applied Microbiology and Biotechnology. 97: 3333-41. PMID 23179615 DOI: 10.1007/S00253-012-4544-8 |
0.351 |
|
| 2013 |
Tai M, Stephanopoulos G. Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production Metabolic Engineering. 15: 1-9. PMID 23026119 DOI: 10.1016/J.Ymben.2012.08.007 |
0.378 |
|
| 2013 |
Fendt S, Stephanopoulos G. Insight out: Advances in understanding metabolism achieved by high-throughput mass spectrometry Biomedical Spectroscopy and Imaging. 2: 1-8. DOI: 10.3233/Bsi-120032 |
0.389 |
|
| 2013 |
Gameiro P, Metelo A, Pérez-Carro R, Alexandra A, Wang Z, Rathmell KW, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O. Abstract B1: Hypoxia inducible factor (HIF) promotes reductive carboxylation by regulating citrate levels and renders VHL-deficient and hypoxic cells sensitive to glutamine deprivation Cancer Research. 73: 1881-1881. DOI: 10.1158/1538-7445.Tim2013-B1 |
0.335 |
|
| 2013 |
Hu P, Rismani-Yazdi H, Stephanopoulos G. Anaerobic CO2fixation by the acetogenic bacteriumMoorella thermoacetica Aiche Journal. 59: 3176-3183. DOI: 10.1002/Aic.14127 |
0.344 |
|
| 2012 |
Jia G, Stephanopoulos G, Gunawan R. Ensemble kinetic modeling of metabolic networks from dynamic metabolic profiles. Metabolites. 2: 891-912. PMID 24957767 DOI: 10.3390/Metabo2040891 |
0.359 |
|
| 2012 |
Stephanopoulos G. Synthetic biology and metabolic engineering. Acs Synthetic Biology. 1: 514-25. PMID 23656228 DOI: 10.1021/Sb300094Q |
0.414 |
|
| 2012 |
Zhou K, Zou R, Stephanopoulos G, Too HP. Metabolite profiling identified methylerythritol cyclodiphosphate efflux as a limiting step in microbial isoprenoid production. Plos One. 7: e47513. PMID 23133596 DOI: 10.1371/journal.pone.0047513 |
0.354 |
|
| 2012 |
Keibler MA, Fendt SM, Stephanopoulos G. Expanding the concepts and tools of metabolic engineering to elucidate cancer metabolism. Biotechnology Progress. 28: 1409-18. PMID 22961737 DOI: 10.1002/btpr.1629 |
0.307 |
|
| 2012 |
Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, ... ... Stephanopoulos G, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nature Chemical Biology. 8: 839-47. PMID 22922757 DOI: 10.1038/Nchembio.1060 |
0.337 |
|
| 2012 |
Zhou H, Cheng JS, Wang BL, Fink GR, Stephanopoulos G. Xylose isomerase overexpression along with engineering of the pentose phosphate pathway and evolutionary engineering enable rapid xylose utilization and ethanol production by Saccharomyces cerevisiae. Metabolic Engineering. 14: 611-22. PMID 22921355 DOI: 10.1016/J.Ymben.2012.07.011 |
0.409 |
|
| 2012 |
Santos CN, Xiao W, Stephanopoulos G. Rational, combinatorial, and genomic approaches for engineering L-tyrosine production in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 109: 13538-43. PMID 22869698 DOI: 10.1073/Pnas.1206346109 |
0.395 |
|
| 2012 |
Hvid H, Fendt SM, Blouin MJ, Birman E, Voisin G, Svendsen AM, Frank R, Vander Heiden MG, Stephanopoulos G, Hansen BF, Pollak M. Stimulation of MC38 tumor growth by insulin analog X10 involves the serine synthesis pathway. Endocrine-Related Cancer. 19: 557-74. PMID 22685267 DOI: 10.1530/Erc-12-0125 |
0.302 |
|
| 2012 |
Yadav VG, De Mey M, Lim CG, Ajikumar PK, Stephanopoulos G. The future of metabolic engineering and synthetic biology: towards a systematic practice. Metabolic Engineering. 14: 233-41. PMID 22629571 DOI: 10.1016/J.Ymben.2012.02.001 |
0.431 |
|
| 2012 |
Jiang M, Stephanopoulos G, Pfeifer BA. Downstream reactions and engineering in the microbially reconstituted pathway for Taxol. Applied Microbiology and Biotechnology. 94: 841-9. PMID 22460591 DOI: 10.1007/S00253-012-4016-1 |
0.38 |
|
| 2012 |
Jiang M, Stephanopoulos G, Pfeifer BA. Toward biosynthetic design and implementation of Escherichia coli-derived paclitaxel and other heterologous polyisoprene compounds. Applied and Environmental Microbiology. 78: 2497-504. PMID 22287010 DOI: 10.1128/Aem.07391-11 |
0.389 |
|
| 2012 |
Walther JL, Metallo CM, Zhang J, Stephanopoulos G. Optimization of 13C isotopic tracers for metabolic flux analysis in mammalian cells. Metabolic Engineering. 14: 162-71. PMID 22198197 DOI: 10.1016/J.Ymben.2011.12.004 |
0.406 |
|
| 2012 |
Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia Nature. 481: 380-384. PMID 22101433 DOI: 10.1038/Nature10602 |
0.419 |
|
| 2012 |
Boghigian BA, Salas D, Ajikumar PK, Stephanopoulos G, Pfeifer BA. Analysis of heterologous taxadiene production in K- and B-derived Escherichia coli. Applied Microbiology and Biotechnology. 93: 1651-61. PMID 21850432 DOI: 10.1007/S00253-011-3528-4 |
0.386 |
|
| 2012 |
Davison BH, San KY, Stephanopoulos G. Stable competitive coexistence in a continuous fermentor with size-selective properties. Biotechnology Progress. 1: 260-9. PMID 20568174 DOI: 10.1002/Btpr.5420010410 |
0.322 |
|
| 2012 |
Zupke C, Stephanopoulos G. Intracellular flux analysis in hybridomas using mass balances and in vitro (13)C nmr. Biotechnology and Bioengineering. 45: 292-303. PMID 18623182 DOI: 10.1002/Bit.260450403 |
0.325 |
|
| 2012 |
Grosz R, Stephanopoulos G. Physiological, biochemical, and mathematical studies of micro-aerobic continuous ethanol fermentation by Saccharomyces cerevisiae. III: mathematical model of cellular energetics and catabolism. Biotechnology and Bioengineering. 36: 1030-40. PMID 18595041 DOI: 10.1002/Bit.260361008 |
0.347 |
|
| 2012 |
Grosz R, Stephanopoulos G. Physiological, biochemical, and mathematical studies of micro-aerobic continuous ethanol fermentation by Saccharomyces cerevisiae. II: intracellular metabolite and enzyme assays at steady state chemostat cultures. Biotechnology and Bioengineering. 36: 1020-9. PMID 18595040 DOI: 10.1002/Bit.260361007 |
0.333 |
|
| 2012 |
Grosz R, Stephanopoulos G. Physiological, biochemical, and mathematical studies of micro-aerobic continuous ethanol fermentation by Saccharomyces cerevisiae. I: hysteresis, oscillations, and maximum specific ethanol productivities in chemostat culture. Biotechnology and Bioengineering. 36: 1006-19. PMID 18595039 DOI: 10.1002/Bit.260361006 |
0.334 |
|
| 2012 |
Davison BH, Stephanopoulos G. Coexistence of S. cerevisiae and E. coli in chemostat under substrate competition and product inhibition. Biotechnology and Bioengineering. 28: 1742-52. PMID 18555289 DOI: 10.1002/Bit.260281119 |
0.325 |
|
| 2012 |
San KY, Stephanopoulos G. Studies on on-line bioreactor identification. IV. Utilization of pH measurements for product estimation. Biotechnology and Bioengineering. 26: 1209-18. PMID 18551638 DOI: 10.1002/Bit.260261009 |
0.335 |
|
| 2012 |
Grosz R, Stephanopoulos G, San KY. Studies on on-line bioreactor identification. III. Sensitivity problems with respiratory and heat evolution measurements. Biotechnology and Bioengineering. 26: 1198-208. PMID 18551637 DOI: 10.1002/Bit.260261008 |
0.315 |
|
| 2012 |
Wirth GJ, Fendt S, Bell EL, Keibler MA, Stephanopoulos G, Olumi AF. Abstract 3234: Metformin shifts prostate cancer metabolism towards a less malignant phenotype Cancer Research. 72: 3234-3234. DOI: 10.1158/1538-7445.Am2012-3234 |
0.384 |
|
| 2012 |
Yang J, Gameiro PA, Stephanopoulos G, Iliopoulos O. Abstract 1132: Regulation of the glutamine-to-lipid pathway by HIF: Reductive TCA cycle is a metabolic signature of VHL deficiency Cancer Research. 72: 1132-1132. DOI: 10.1158/1538-7445.Am2012-1132 |
0.387 |
|
| 2012 |
Young JD, Shastri AA, Stephanopoulos G, Morgan JA. Corrigendum to “Mapping photoautotrophic metabolism with isotopically nonstationary 13C flux analysis” [Metab. Eng. 13 (2011) 656–665] Metabolic Engineering. 14: 185. DOI: 10.1016/J.Ymben.2012.01.005 |
0.347 |
|
| 2012 |
Zhang J, Babtie A, Stephanopoulos G. Metabolic engineering: enabling technology of a bio-based economy Current Opinion in Chemical Engineering. 1: 355-362. DOI: 10.1016/J.Coche.2012.09.003 |
0.373 |
|
| 2011 |
Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM, Locasale JW. Metabolic pathway alterations that support cell proliferation. Cold Spring Harbor Symposia On Quantitative Biology. 76: 325-34. PMID 22262476 DOI: 10.1101/Sqb.2012.76.010900 |
0.448 |
|
| 2011 |
Dugar D, Stephanopoulos G. Relative potential of biosynthetic pathways for biofuels and bio-based products. Nature Biotechnology. 29: 1074-8. PMID 22158355 DOI: 10.1038/Nbt.2055 |
0.349 |
|
| 2011 |
Young JD, Shastri AA, Stephanopoulos G, Morgan JA. Mapping photoautotrophic metabolism with isotopically nonstationary (13)C flux analysis. Metabolic Engineering. 13: 656-65. PMID 21907300 DOI: 10.1016/J.Ymben.2011.08.002 |
0.4 |
|
| 2011 |
Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes & Development. 25: 1716-33. PMID 21852536 DOI: 10.1101/Gad.16771811 |
0.401 |
|
| 2011 |
Gaglio D, Metallo CM, Gameiro PA, Hiller K, Danna LS, Balestrieri C, Alberghina L, Stephanopoulos G, Chiaradonna F. Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Molecular Systems Biology. 7: 523. PMID 21847114 DOI: 10.1038/Msb.2011.56 |
0.367 |
|
| 2011 |
Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, ... ... Stephanopoulos G, et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genetics. 43: 869-74. PMID 21804546 DOI: 10.1038/Ng.890 |
0.378 |
|
| 2011 |
Hiller K, Metallo C, Stephanopoulos G. Elucidation of cellular metabolism via metabolomics and stable-isotope assisted metabolomics Current Pharmaceutical Biotechnology. 12: 1075-1086. PMID 21466455 DOI: 10.2174/138920111795909096 |
0.377 |
|
| 2011 |
Antoniewicz MR, Kelleher JK, Stephanopoulos G. Measuring deuterium enrichment of glucose hydrogen atoms by gas chromatography/mass spectrometry. Analytical Chemistry. 83: 3211-6. PMID 21413777 DOI: 10.1021/Ac200012P |
0.556 |
|
| 2011 |
Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G. Tracking cellular metabolomics in lipoapoptosis- and steatosis-developing liver cells. Molecular Biosystems. 7: 1409-19. PMID 21327189 DOI: 10.1039/C0Mb00309C |
0.359 |
|
| 2011 |
Santos CN, Koffas M, Stephanopoulos G. Optimization of a heterologous pathway for the production of flavonoids from glucose. Metabolic Engineering. 13: 392-400. PMID 21320631 DOI: 10.1016/J.Ymben.2011.02.002 |
0.665 |
|
| 2011 |
Grassian AR, Metallo CM, Stephanopoulos G, Brugge JS. Abstract 2802: Evaluation of metabolic changes induced by loss of extracellular matrix attachment using 13C Flux analysis Cancer Research. 71: 2802-2802. DOI: 10.1158/1538-7445.Am2011-2802 |
0.394 |
|
| 2010 |
Lam FH, Hartner FS, Fink GR, Stephanopoulos G. Enhancing stress resistance and production phenotypes through transcriptome engineering. Methods in Enzymology. 470: 509-32. PMID 20946823 DOI: 10.1016/S0076-6879(10)70020-3 |
0.359 |
|
| 2010 |
Ajikumar PK, Xiao WH, Tyo KE, Wang Y, Simeon F, Leonard E, Mucha O, Phon TH, Pfeifer B, Stephanopoulos G. Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli. Science (New York, N.Y.). 330: 70-4. PMID 20929806 DOI: 10.1126/Science.1191652 |
0.674 |
|
| 2010 |
Noguchi Y, Nishikata N, Shikata N, Kimura Y, Aleman JO, Young JD, Koyama N, Kelleher JK, Takahashi M, Stephanopoulos G. Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice. Plos One. 5: e12057. PMID 20706589 DOI: 10.1371/Journal.Pone.0012057 |
0.301 |
|
| 2010 |
Jung SC, Smith CL, Lee KS, Hong ME, Kweon DH, Stephanopoulos G, Jin YS. Restoration of growth phenotypes of Escherichia coli DH5alpha in minimal media through reversal of a point mutation in purB. Applied and Environmental Microbiology. 76: 6307-9. PMID 20675450 DOI: 10.1128/Aem.01210-10 |
0.471 |
|
| 2010 |
Leonard E, Ajikumar PK, Thayer K, Xiao WH, Mo JD, Tidor B, Stephanopoulos G, Prather KLJ. Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control Proceedings of the National Academy of Sciences of the United States of America. 107: 13654-13659. PMID 20643967 DOI: 10.1073/Pnas.1006138107 |
0.712 |
|
| 2010 |
Fischer CR, Tseng HC, Tai M, Prather KLJ, Stephanopoulos G. Assessment of heterologous butyrate and butanol pathway activity by measurement of intracellular pathway intermediates in recombinant Escherichia coli Applied Microbiology and Biotechnology. 88: 265-275. PMID 20625717 DOI: 10.1007/S00253-010-2749-2 |
0.404 |
|
| 2010 |
Hiller K, Metallo CM, Kelleher JK, Stephanopoulos G. Nontargeted elucidation of metabolic pathways using stable-isotope tracers and mass spectrometry. Analytical Chemistry. 82: 6621-8. PMID 20608743 DOI: 10.1021/Ac1011574 |
0.393 |
|
| 2010 |
Klein-Marcuschamer D, Stephanopoulos G. Method for designing and optimizing random-search libraries for strain improvement. Applied and Environmental Microbiology. 76: 5541-6. PMID 20581192 DOI: 10.1128/Aem.00828-10 |
0.325 |
|
| 2010 |
Yadav VG, Stephanopoulos G. Reevaluating synthesis by biology. Current Opinion in Microbiology. 13: 371-6. PMID 20447859 DOI: 10.1016/J.Mib.2010.04.002 |
0.427 |
|
| 2010 |
Klein-Marcuschamer D, Yadav VG, Ghaderi A, Stephanopoulos GN. De Novo metabolic engineering and the promise of synthetic DNA. Advances in Biochemical Engineering/Biotechnology. 120: 101-31. PMID 20186529 DOI: 10.1007/10_2009_52 |
0.339 |
|
| 2010 |
Tyo KE, Fischer CR, Simeon F, Stephanopoulos G. Analysis of polyhydroxybutyrate flux limitations by systematic genetic and metabolic perturbations. Metabolic Engineering. 12: 187-95. PMID 19879956 DOI: 10.1016/J.Ymben.2009.10.005 |
0.428 |
|
| 2010 |
Vallino JJ, Stephanopoulos G. Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction. Biotechnology and Bioengineering. 41: 633-46. PMID 18609599 DOI: 10.1002/Bit.260410606 |
0.411 |
|
| 2010 |
Kiss RD, Stephanopoulos G. Culture instability of auxotrophic amino acid producers. Biotechnology and Bioengineering. 40: 75-85. PMID 18601047 DOI: 10.1002/Bit.260400112 |
0.321 |
|
| 2010 |
Kiss RD, Stephanopoulos G. Metabolic characterization of a L-lysine-producing strain by continuous culture. Biotechnology and Bioengineering. 39: 565-74. PMID 18600983 DOI: 10.1002/Bit.260390512 |
0.375 |
|
| 2010 |
Stephanopoulos G, Metallo C. Developing an integrated picture of tumor cell physiology using isotope tracer data and metabolic flux analysis Journal of Biotechnology. 150: 91-92. DOI: 10.1016/J.Jbiotec.2010.08.236 |
0.349 |
|
| 2009 |
Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G. Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis. The Journal of Biological Chemistry. 284: 33425-36. PMID 19758988 DOI: 10.1074/Jbc.M109.049478 |
0.328 |
|
| 2009 |
Alper H, Stephanopoulos G. Engineering for biofuels: exploiting innate microbial capacity or importing biosynthetic potential? Nature Reviews. Microbiology. 7: 715-23. PMID 19756010 DOI: 10.1038/Nrmicro2186 |
0.429 |
|
| 2009 |
Tyo KE, Ajikumar PK, Stephanopoulos G. Stabilized gene duplication enables long-term selection-free heterologous pathway expression. Nature Biotechnology. 27: 760-5. PMID 19633654 DOI: 10.1038/Nbt.1555 |
0.382 |
|
| 2009 |
Metallo CM, Walther JL, Stephanopoulos G. Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells. Journal of Biotechnology. 144: 167-74. PMID 19622376 DOI: 10.1016/J.Jbiotec.2009.07.010 |
0.407 |
|
| 2009 |
Tyo KE, Jin YS, Espinoza FA, Stephanopoulos G. Identification of gene disruptions for increased poly-3-hydroxybutyrate accumulation in Synechocystis PCC 6803. Biotechnology Progress. 25: 1236-43. PMID 19606467 DOI: 10.1002/Btpr.228 |
0.566 |
|
| 2009 |
Moxley JF, Jewett MC, Antoniewicz MR, Villas-Boas SG, Alper H, Wheeler RT, Tong L, Hinnebusch AG, Ideker T, Nielsen J, Stephanopoulos G. Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p. Proceedings of the National Academy of Sciences of the United States of America. 106: 6477-82. PMID 19346491 DOI: 10.1073/Pnas.0811091106 |
0.674 |
|
| 2009 |
Klein-Marcuschamer D, Santos CN, Yu H, Stephanopoulos G. Mutagenesis of the bacterial RNA polymerase alpha subunit for improvement of complex phenotypes. Applied and Environmental Microbiology. 75: 2705-11. PMID 19251886 DOI: 10.1128/Aem.01888-08 |
0.333 |
|
| 2008 |
Stephanopoulos G. Metabolic engineering: enabling technology for biofuels production. Metabolic Engineering. 10: 293-4. PMID 19059122 DOI: 10.1016/J.Ymben.2008.10.003 |
0.384 |
|
| 2008 |
Fischer CR, Klein-Marcuschamer D, Stephanopoulos G. Selection and optimization of microbial hosts for biofuels production. Metabolic Engineering. 10: 295-304. PMID 18655844 DOI: 10.1016/J.Ymben.2008.06.009 |
0.358 |
|
| 2008 |
Yoo H, Antoniewicz MR, Stephanopoulos G, Kelleher JK. Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line. The Journal of Biological Chemistry. 283: 20621-7. PMID 18364355 DOI: 10.1074/Jbc.M706494200 |
0.654 |
|
| 2008 |
Ajikumar PK, Tyo K, Carlsen S, Mucha O, Phon TH, Stephanopoulos G. Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms. Molecular Pharmaceutics. 5: 167-90. PMID 18355030 DOI: 10.1021/Mp700151B |
0.403 |
|
| 2008 |
Santos CN, Stephanopoulos G. Combinatorial engineering of microbes for optimizing cellular phenotype. Current Opinion in Chemical Biology. 12: 168-76. PMID 18275860 DOI: 10.1016/J.Cbpa.2008.01.017 |
0.356 |
|
| 2008 |
Klein-Marcuschamer D, Stephanopoulos G. Assessing the potential of mutational strategies to elicit new phenotypes in industrial strains. Proceedings of the National Academy of Sciences of the United States of America. 105: 2319-24. PMID 18252819 DOI: 10.1073/Pnas.0712177105 |
0.33 |
|
| 2008 |
Alper H, Stephanopoulos G. Uncovering the gene knockout landscape for improved lycopene production in E. coli Applied Microbiology and Biotechnology. 78: 801-810. PMID 18239914 DOI: 10.1007/S00253-008-1373-X |
0.39 |
|
| 2008 |
Yu H, Stephanopoulos G. Metabolic engineering of Escherichia coli for biosynthesis of hyaluronic acid. Metabolic Engineering. 10: 24-32. PMID 17959405 DOI: 10.1016/J.Ymben.2007.09.001 |
0.384 |
|
| 2008 |
Young JD, Walther JL, Antoniewicz MR, Yoo H, Stephanopoulos G. An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis. Biotechnology and Bioengineering. 99: 686-99. PMID 17787013 DOI: 10.1002/Bit.21632 |
0.634 |
|
| 2007 |
Lütke-Eversloh T, Stephanopoulos G. Combinatorial pathway analysis for improved L-tyrosine production in Escherichia coli: identification of enzymatic bottlenecks by systematic gene overexpression. Metabolic Engineering. 10: 69-77. PMID 18243023 DOI: 10.1016/J.Ymben.2007.12.001 |
0.33 |
|
| 2007 |
Santos CN, Stephanopoulos G. Melanin-based high-throughput screen for L-tyrosine production in Escherichia coli. Applied and Environmental Microbiology. 74: 1190-7. PMID 18156325 DOI: 10.1128/Aem.02448-07 |
0.325 |
|
| 2007 |
Lütke-Eversloh T, Santos CNS, Stephanopoulos G. Perspectives of biotechnological production of l -tyrosine and its applications Applied Microbiology and Biotechnology. 77: 751-762. PMID 17968539 DOI: 10.1007/S00253-007-1243-Y |
0.33 |
|
| 2007 |
Antoniewicz MR, Kelleher JK, Stephanopoulos G. Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis. Analytical Chemistry. 79: 7554-9. PMID 17822305 DOI: 10.1021/Ac0708893 |
0.641 |
|
| 2007 |
Klein-Marcuschamer D, Ajikumar PK, Stephanopoulos G. Engineering microbial cell factories for biosynthesis of isoprenoid molecules: beyond lycopene. Trends in Biotechnology. 25: 417-24. PMID 17681626 DOI: 10.1016/J.Tibtech.2007.07.006 |
0.405 |
|
| 2007 |
Jin YS, Stephanopoulos G. Multi-dimensional gene target search for improving lycopene biosynthesis in Escherichia coli. Metabolic Engineering. 9: 337-47. PMID 17509919 DOI: 10.1016/J.Ymben.2007.03.003 |
0.531 |
|
| 2007 |
Antoniewicz MR, Kraynie DF, Laffend LA, González-Lergier J, Kelleher JK, Stephanopoulos G. Metabolic flux analysis in a nonstationary system: fed-batch fermentation of a high yielding strain of E. coli producing 1,3-propanediol. Metabolic Engineering. 9: 277-92. PMID 17400499 DOI: 10.1016/J.Ymben.2007.01.003 |
0.69 |
|
| 2007 |
Alper H, Stephanopoulos G. Global transcription machinery engineering: A new approach for improving cellular phenotype Metabolic Engineering. 9: 258-267. PMID 17292651 DOI: 10.1016/J.Ymben.2006.12.002 |
0.364 |
|
| 2007 |
Stephanopoulos G. Challenges in engineering microbes for biofuels production. Science (New York, N.Y.). 315: 801-4. PMID 17289987 DOI: 10.1126/Science.1139612 |
0.346 |
|
| 2007 |
Lütke-Eversloh T, Stephanopoulos G. L-tyrosine production by deregulated strains of Escherichia coli. Applied Microbiology and Biotechnology. 75: 103-110. PMID 17221195 DOI: 10.1007/S00253-006-0792-9 |
0.328 |
|
| 2007 |
Antoniewicz MR, Kelleher JK, Stephanopoulos G. Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions. Metabolic Engineering. 9: 68-86. PMID 17088092 DOI: 10.1016/J.Ymben.2006.09.001 |
0.639 |
|
| 2007 |
Nevoigt E, Fischer C, Mucha O, Matthäus F, Stahl U, Stephanopoulos G. Engineering promoter regulation. Biotechnology and Bioengineering. 96: 550-8. PMID 16964624 DOI: 10.1002/Bit.21129 |
0.325 |
|
| 2006 |
Alper H, Moxley J, Nevoigt E, Fink GR, Stephanopoulos G. Engineering yeast transcription machinery for improved ethanol tolerance and production. Science (New York, N.Y.). 314: 1565-8. PMID 17158319 DOI: 10.1126/Science.1131969 |
0.325 |
|
| 2006 |
Antoniewicz MR, Stephanopoulos G, Kelleher JK. Evaluation of regression models in metabolic physiology: predicting fluxes from isotopic data without knowledge of the pathway. Metabolomics : Official Journal of the Metabolomic Society. 2: 41-52. PMID 17066125 DOI: 10.1007/S11306-006-0018-2 |
0.644 |
|
| 2006 |
Nevoigt E, Kohnke J, Fischer CR, Alper H, Stahl U, Stephanopoulos G. Engineering of promoter replacement cassettes for fine-tuning of gene expression in Saccharomyces cerevisiae Applied and Environmental Microbiology. 72: 5266-5273. PMID 16885275 DOI: 10.1128/Aem.00530-06 |
0.319 |
|
| 2006 |
Antoniewicz MR, Kelleher JK, Stephanopoulos G. Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements. Metabolic Engineering. 8: 324-37. PMID 16631402 DOI: 10.1016/J.Ymben.2006.01.004 |
0.643 |
|
| 2006 |
Alper H, Miyaoku K, Stephanopoulos G. Characterization of lycopene-overproducing E. coli strains in high cell density fermentations Applied Microbiology and Biotechnology. 72: 968-974. PMID 16502313 DOI: 10.1007/S00253-006-0357-Y |
0.374 |
|
| 2005 |
Jin YS, Alper H, Yang YT, Stephanopoulos G. Improvement of xylose uptake and ethanol production in recombinant Saccharomyces cerevisiae through an inverse metabolic engineering approach. Applied and Environmental Microbiology. 71: 8249-56. PMID 16332810 DOI: 10.1128/Aem.71.12.8249-8256.2005 |
0.57 |
|
| 2005 |
Alper H, Fischer C, Nevoigt E, Stephanopoulos G. Tuning genetic control through promoter engineering Proceedings of the National Academy of Sciences of the United States of America. 102: 12678-12683. PMID 16123130 DOI: 10.1073/Pnas.0504604102 |
0.371 |
|
| 2005 |
Koffas M, Stephanopoulos G. Strain improvement by metabolic engineering: lysine production as a case study for systems biology. Current Opinion in Biotechnology. 16: 361-6. PMID 15961038 DOI: 10.1016/J.Copbio.2005.04.010 |
0.666 |
|
| 2005 |
Alper H, Jin YS, Moxley JF, Stephanopoulos G. Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli. Metabolic Engineering. 7: 155-64. PMID 15885614 DOI: 10.1016/J.Ymben.2004.12.003 |
0.575 |
|
| 2005 |
Alper H, Miyaoku K, Stephanopoulos G. Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets Nature Biotechnology. 23: 612-616. PMID 15821729 DOI: 10.1038/Nbt1083 |
0.379 |
|
| 2005 |
Villas-Bôas SG, Moxley JF, Akesson M, Stephanopoulos G, Nielsen J. High-throughput metabolic state analysis: the missing link in integrated functional genomics of yeasts. The Biochemical Journal. 388: 669-77. PMID 15667247 DOI: 10.1042/Bj20041162 |
0.419 |
|
| 2005 |
Styczynski MP, Stephanopoulos G. Overview of computational methods for the inference of gene regulatory networks Computers & Chemical Engineering. 29: 519-534. DOI: 10.1016/J.Compchemeng.2004.08.029 |
0.314 |
|
| 2005 |
Stephanopoulos G, Jensen KL. Metabolic engineering: Developing new products and processes by constructing functioning biosynthetic pathwaysin vivo Aiche Journal. 51: 3091-3093. DOI: 10.1002/Aic.10725 |
0.397 |
|
| 2004 |
Heijnen JJ, van Gulik WM, Shimizu H, Stephanopoulos G. Metabolic flux control analysis of branch points: an improved approach to obtain flux control coefficients from large perturbation data. Metabolic Engineering. 6: 391-400. PMID 15491867 DOI: 10.1016/J.Ymben.2004.07.002 |
0.346 |
|
| 2004 |
Stephanopoulos G, Alper H, Moxley J. Exploiting biological complexity for strain improvement through systems biology. Nature Biotechnology. 22: 1261-7. PMID 15470466 DOI: 10.1038/Nbt1016 |
0.301 |
|
| 2004 |
Lynch MD, Gill RT, Stephanopoulos G. Mapping phenotypic landscapes using DNA micro-arrays. Metabolic Engineering. 6: 177-85. PMID 15256207 DOI: 10.1016/J.Ymben.2004.01.002 |
0.622 |
|
| 2004 |
Yoo H, Stephanopoulos G, Kelleher JK. Quantifying carbon sources for de novo lipogenesis in wild-type and IRS-1 knockout brown adipocytes. Journal of Lipid Research. 45: 1324-32. PMID 15102881 DOI: 10.1194/Jlr.M400031-Jlr200 |
0.35 |
|
| 2004 |
Jung GY, Stephanopoulos G. A functional protein chip for pathway optimization and in vitro metabolic engineering. Science (New York, N.Y.). 304: 428-31. PMID 15087547 DOI: 10.1126/Science.1096920 |
0.6 |
|
| 2004 |
Padilla L, Krämer R, Stephanopoulos G, Agosin E. Overproduction of trehalose: heterologous expression of Escherichia coli trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase in Corynebacterium glutamicum. Applied and Environmental Microbiology. 70: 370-6. PMID 14711665 DOI: 10.1128/Aem.70.1.370-376.2004 |
0.4 |
|
| 2004 |
Alper H, Stephanopoulos G. Metabolic engineering challenges in the post-genomic era Chemical Engineering Science. 59: 5009-5017. DOI: 10.1016/J.Ces.2004.09.027 |
0.429 |
|
| 2003 |
Klapa MI, Aon JC, Stephanopoulos G. Systematic quantification of complex metabolic flux networks using stable isotopes and mass spectrometry. European Journal of Biochemistry / Febs. 270: 3525-42. PMID 12919317 DOI: 10.1046/J.1432-1033.2003.03732.X |
0.384 |
|
| 2003 |
Koffas MA, Jung GY, Stephanopoulos G. Engineering metabolism and product formation in Corynebacterium glutamicum by coordinated gene overexpression. Metabolic Engineering. 5: 32-41. PMID 12749842 DOI: 10.1016/S1096-7176(03)00002-8 |
0.766 |
|
| 2003 |
Klapa MI, Aon JC, Stephanopoulos G. Ion-trap mass spectrometry used in combination with gas chromatography for high-resolution metabolic flux determination. Biotechniques. 34: 832-6, 838, 840 pass. PMID 12703309 DOI: 10.2144/03344Pt02 |
0.352 |
|
| 2003 |
Chan C, Hwang D, Stephanopoulos GN, Yarmush ML, Stephanopoulos G. Application of multivariate analysis to optimize function of cultured hepatocytes. Biotechnology Progress. 19: 580-98. PMID 12675604 DOI: 10.1021/Bp025660H |
0.367 |
|
| 2003 |
Varela C, Agosin E, Baez M, Klapa M, Stephanopoulos G. Metabolic flux redistribution in Corynebacterium glutamicum in response to osmotic stress. Applied Microbiology and Biotechnology. 60: 547-55. PMID 12536254 DOI: 10.1007/S00253-002-1120-7 |
0.388 |
|
| 2003 |
Stephanopoulos G. Metabolic engineering by genome shuffling. Nature Biotechnology. 20: 666-8. PMID 12089547 DOI: 10.1038/Nbt0702-666 |
0.337 |
|
| 2002 |
Yuk IH, Wildt S, Jolicoeur M, Wang DI, Stephanopoulos G. A GFP-based screen for growth-arrested, recombinant protein-producing cells. Biotechnology and Bioengineering. 79: 74-82. PMID 17590933 DOI: 10.1002/Bit.10293 |
0.307 |
|
| 2002 |
Koffas MA, Jung GY, Aon JC, Stephanopoulos G. Effect of pyruvate carboxylase overexpression on the physiology of Corynebacterium glutamicum. Applied and Environmental Microbiology. 68: 5422-8. PMID 12406733 DOI: 10.1128/Aem.68.11.5422-5428.2002 |
0.732 |
|
| 2002 |
Gill RT, Katsoulakis E, Schmitt W, Taroncher-Oldenburg G, Misra J, Stephanopoulos G. Genome-wide dynamic transcriptional profiling of the light-to-dark transition in Synechocystis sp. strain PCC 6803. Journal of Bacteriology. 184: 3671-81. PMID 12057963 DOI: 10.1128/Jb.184.13.3671-3681.2002 |
0.561 |
|
| 2002 |
Gill RT, Wildt S, Yang YT, Ziesman S, Stephanopoulos G. Genome-wide screening for trait conferring genes using DNA microarrays. Proceedings of the National Academy of Sciences of the United States of America. 99: 7033-8. PMID 11997466 DOI: 10.1073/Pnas.102154799 |
0.587 |
|
| 2002 |
Stafford DE, Yanagimachi KS, Lessard PA, Rijhwani SK, Sinskey AJ, Stephanopoulos G. Optimizing bioconversion pathways through systems analysis and metabolic engineering. Proceedings of the National Academy of Sciences of the United States of America. 99: 1801-6. PMID 11854482 DOI: 10.1073/Pnas.032681699 |
0.429 |
|
| 2002 |
Stafford DE, Yanagimachi KS, Stephanopoulos G. Metabolic engineering of indene bioconversion in Rhodococcus sp. Advances in Biochemical Engineering/Biotechnology. 73: 85-101. PMID 11816813 DOI: 10.1007/3-540-45300-8_5 |
0.318 |
|
| 2002 |
Stephanopoulos G, Gill RT. After a decade of progress, an expanded role for metabolic engineering. Advances in Biochemical Engineering/Biotechnology. 73: 1-8. PMID 11816808 DOI: 10.1007/3-540-45300-8_1 |
0.639 |
|
| 2002 |
Koffas M, Roberge C, Lee K, Stephanopoulos G. Metabolic engineering. Annual Review of Biomedical Engineering. 1: 535-57. PMID 11701499 DOI: 10.1146/annurev.bioeng.1.1.535 |
0.33 |
|
| 2002 |
Stephanopoulos G, Stafford DE. Metabolic engineering: a new frontier of chemical reaction engineering Chemical Engineering Science. 57: 2595-2602. DOI: 10.1016/S0009-2509(02)00088-X |
0.44 |
|
| 2002 |
Stephanopoulos G. The Jay Bailey Young Investigator Best Paper Award in Metabolic Engineering Metabolic Engineering. 4: 107-110. DOI: 10.1006/Mben.2002.0223 |
0.373 |
|
| 2002 |
Stephanopoulos G. Metabolic engineering: Perspective of a chemical engineer Aiche Journal. 48: 920-926. DOI: 10.1002/Aic.690480502 |
0.393 |
|
| 2001 |
Yanagimachi KS, Stafford DE, Dexter AF, Sinskey AJ, Drew S, Stephanopoulos G. Application of radiolabeled tracers to biocatalytic flux analysis. European Journal of Biochemistry. 268: 4950-60. PMID 11559364 DOI: 10.1046/J.0014-2956.2001.02426.X |
0.351 |
|
| 2001 |
Stephanopoulos G, Kelleher J. Biochemistry: How to make a superior cell Science. 292: 2024-2025. PMID 11408647 DOI: 10.1126/Science.1062556 |
0.417 |
|
| 2001 |
Balcarcel RR, Stephanopoulos G. Rapamycin reduces hybridoma cell death and enhances monoclonal antibody production. Biotechnology and Bioengineering. 76: 1-10. PMID 11400101 DOI: 10.1002/Bit.1020 |
0.33 |
|
| 2001 |
Stafford DE, Stephanopoulos G. Metabolic engineering as an integrating platform for strain development. Current Opinion in Microbiology. 4: 336-40. PMID 11378489 DOI: 10.1016/S1369-5274(00)00214-9 |
0.415 |
|
| 2001 |
Taroncher-Oldenburg G, Stephanopoulos G. Targeted, PCR-based gene disruption in cyanobacteria: inactivation of the polyhydroxyalkanoic acid synthase genes in Synechocystis sp. PCC6803. Applied Microbiology and Biotechnology. 54: 677-80. PMID 11131394 DOI: 10.1007/S002530000450 |
0.323 |
|
| 2000 |
Stephanopoulos G. Bioinformatics and metabolic engineering Metabolic Engineering. 2: 157-158. PMID 11056058 DOI: 10.1006/Mben.2000.0157 |
0.387 |
|
| 2000 |
Taroncher-Oldenburg G, Nishina K, Stephanopoulos G. Identification and analysis of the polyhydroxyalkanoate-specific beta-ketothiolase and acetoacetyl coenzyme A reductase genes in the cyanobacterium Synechocystis sp. strain PCC6803. Applied and Environmental Microbiology. 66: 4440-8. PMID 11010896 DOI: 10.1128/Aem.66.10.4440-4448.2000 |
0.309 |
|
| 2000 |
Shanks JV, Stephanopoulos G. Biochemical engineering. Bridging the gap between gene and product. Current Opinion in Biotechnology. 11: 169-70. PMID 10809544 DOI: 10.1016/S0958-1669(00)00076-8 |
0.429 |
|
| 1999 |
Stephanopoulos G. Metabolic fluxes and metabolic engineering. Metabolic Engineering. 1: 1-11. PMID 10935750 DOI: 10.1006/Mben.1998.0101 |
0.422 |
|
| 1999 |
Simpson TW, Follstad BD, Stephanopoulos G. Analysis of the pathway structure of metabolic networks. Journal of Biotechnology. 71: 207-23. PMID 10483107 DOI: 10.1016/S0168-1656(99)00023-1 |
0.371 |
|
| 1999 |
Lee K, Berthiaume F, Stephanopoulos GN, Yarmush ML. Metabolic flux analysis: A powerful tool for monitoring tissue function Tissue Engineering. 5: 347-368. PMID 10477857 DOI: 10.1089/Ten.1999.5.347 |
0.318 |
|
| 1999 |
Treadway SL, Yanagimachi KS, Lankenau E, Lessard PA, Stephanopoulos G, Sinskey AJ. Isolation and characterization of indene bioconversion genes from Rhodococcus strain I24. Applied Microbiology and Biotechnology. 51: 786-93. PMID 10422226 DOI: 10.1007/S002530051463 |
0.302 |
|
| 1999 |
Follstad BD, Balcarcel RR, Stephanopoulos G, Wang DI. Metabolic flux analysis of hybridoma continuous culture steady state multiplicity. Biotechnology and Bioengineering. 63: 675-83. PMID 10397824 DOI: 10.1002/(Sici)1097-0290(19990620)63:6<675::Aid-Bit5>3.0.Co;2-R |
0.369 |
|
| 1999 |
Shaw-Reid CA, McCormick MM, Sinskey AJ, Stephanopoulos G. Flux through the tetrahydrodipicolinate succinylase pathway is dispensable for L-lysine production in Corynebacterium glutamicum. Applied Microbiology and Biotechnology. 51: 325-33. PMID 10222581 DOI: 10.1007/S002530051398 |
0.344 |
|
| 1999 |
Klapa MI, Park SM, Sinskey AJ, Stephanopoulos G. Metabolite and isotopomer balancing in the analysis of metabolic cycles: I. Theory. Biotechnology and Bioengineering. 62: 375-391. PMID 10099550 DOI: 10.1002/(Sici)1097-0290(19990220)62:4<375::Aid-Bit1>3.0.Co;2-O |
0.351 |
|
| 1999 |
Nyberg GB, Balcarcel RR, Follstad BD, Stephanopoulos G, Wang DI. Metabolism of peptide amino acids by Chinese hamster ovary cells grown in a complex medium. Biotechnology and Bioengineering. 62: 324-35. PMID 10099544 DOI: 10.1002/(Sici)1097-0290(19990205)62:3<324::Aid-Bit9>3.0.Co;2-C |
0.391 |
|
| 1999 |
Park SM, Klapa MI, Sinskey AJ, Stephanopoulos G. Metabolite and isotopomer balancing in the analysis of metabolic cycles: II. Applications Biotechnology and Bioengineering. 62: 392-401. PMID 9921151 DOI: 10.1002/(Sici)1097-0290(19990220)62:4<392::Aid-Bit2>3.0.Co;2-S |
0.391 |
|
| 1998 |
Simpson TW, Shimizu H, Stephanopoulos G. Experimental determination of group flux control coefficients in metabolic networks Biotechnology and Bioengineering. 58: 149-53. PMID 10191384 DOI: 10.1002/(Sici)1097-0290(19980420)58:2/3<149::Aid-Bit6>3.0.Co;2-L |
0.356 |
|
| 1998 |
Follstad BD, Stephanopoulos G. Effect of reversible reactions on isotope label redistribution--analysis of the pentose phosphate pathway. European Journal of Biochemistry. 252: 360-71. PMID 9546650 DOI: 10.1046/J.1432-1327.1998.2520360.X |
0.367 |
|
| 1997 |
Park SM, Sinskey AJ, Stephanopoulos G. Metabolic and physiological studies of Corynebacterium glutamicum mutants. Biotechnology and Bioengineering. 55: 864-79. PMID 18636597 DOI: 10.1002/(Sici)1097-0290(19970920)55:6<864::Aid-Bit5>3.0.Co;2-E |
0.427 |
|
| 1997 |
Stephanopoulos G, Simpson TW. Flux amplification in complex metabolic networks Chemical Engineering Science. 52: 2607-2627. DOI: 10.1016/S0009-2509(97)00077-8 |
0.34 |
|
| 1997 |
Park SM, Shaw-Reid C, Sinskey AJ, Stephanopoulos G. Elucidation of anaplerotic pathways in Corynebacterium glutamicum via 13 C-NMR spectroscopy and GC-MS Applied Microbiology and Biotechnology. 47: 430-440. DOI: 10.1007/S002530050952 |
0.348 |
|
| 1996 |
Grampp GE, Applegate MA, Stephanopoulos G. Cyclic operation of ceramic-matrix animal cell bioreactors for controlled secretion of an endocrine hormone. A comparison of single-pass and recycle modes of operation Biotechnology Progress. 12: 837-846. PMID 8983208 DOI: 10.1021/Bp960066R |
0.313 |
|
| 1995 |
Zupke C, Sinskey AJ, Stephanopoulos G. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Applied Microbiology and Biotechnology. 44: 27-36. PMID 8579834 DOI: 10.1007/Bf00164476 |
0.315 |
|
| 1995 |
Colón GE, Jetten MS, Nguyen TT, Gubler ME, Follettie MT, Sinskey AJ, Stephanopoulos G. Effect of inducible thrB expression on amino acid production in Corynebacterium lactofermentum ATCC 21799. Applied and Environmental Microbiology. 61: 74-8. PMID 7887627 DOI: 10.1128/Aem.61.1.74-78.1995 |
0.362 |
|
| 1995 |
Simpson TW, Colón GE, Stephanopoulos G. Two paradigms of metabolic engineering applied to amino acid biosynthesis. Biochemical Society Transactions. 23: 381-7. PMID 7672413 DOI: 10.1042/Bst0230381 |
0.374 |
|
| 1995 |
Colón GE, Nguyen TT, Jetten MS, Sinskey AJ, Stephanopoulos G. Production of isoleucine by overexpression of ilvA in a Corynebacterium lactofermentum threonine producer. Applied Microbiology and Biotechnology. 43: 482-8. PMID 7632398 DOI: 10.1007/Bf00218453 |
0.368 |
|
| 1994 |
Chung JD, Stephanopoulos G, Ireton K, Grossman AD. Gene expression in single cells of Bacillus subtilis: evidence that a threshold mechanism controls the initiation of sporulation. Journal of Bacteriology. 176: 1977-84. PMID 8144465 DOI: 10.1128/Jb.176.7.1977-1984.1994 |
0.312 |
|
| 1994 |
Stephanopoulos G. Metabolic engineering. Current Opinion in Biotechnology. 5: 196-200. PMID 7764800 DOI: 10.1016/s0958-1669(05)80036-9 |
0.313 |
|
| 1994 |
Vallino JJ, Stephanopoulos G. Carbon Flux Distributions at the Glucose 6-Phosphate Branch Point in Corynebacterium glutamicum during Lysine Overproduction Biotechnology Progress. 10: 327-334. DOI: 10.1021/Bp00027A014 |
0.368 |
|
| 1994 |
Vallino JJ, Stephanopoulos G. Carbon Flux Distributions at the Pyruvate Branch Point in Corynebacterium glutamicum during Lysine Overproduction Biotechnology Progress. 10: 320-326. DOI: 10.1021/Bp00027A013 |
0.408 |
|
| 1994 |
Gubler M, Park SM, Jetten M, Stephanopoulos G, Sinskey AJ. Effects of phosphoenol pyruvate carboxylase deficiency on metabolism and lysine production in Corynebacterium glutamicum Applied Microbiology and Biotechnology. 40: 857-863. DOI: 10.1007/Bf00173988 |
0.363 |
|
| 1993 |
Park S, Stephanopoulos G. Packed bed bioreactor with porous ceramic beads for animal cell culture. Biotechnology and Bioengineering. 41: 25-34. PMID 18601242 DOI: 10.1002/Bit.260410105 |
0.3 |
|
| 1993 |
Stephanopoulos G, Sinskey AJ. Metabolic engineering — methodologies and future prospects Trends in Biotechnology. 11: 392-396. PMID 7764086 DOI: 10.1016/0167-7799(93)90099-U |
0.432 |
|
| 1992 |
Grampp GE, Sambanis A, Stephanopoulos GN. Use of regulated secretion in protein production from animal cells: an overview Advances in Biochemical Engineering/Biotechnology. 46: 35-62. PMID 1636482 |
0.581 |
|
| 1991 |
Stephanopoulos G, Vallino JJ. Network rigidity and metabolic engineering in metabolite overproduction. Science. 252: 1675-1681. PMID 1904627 DOI: 10.1126/Science.1904627 |
0.442 |
|
| 1991 |
Kiss RD, Stephanopoulos G. Metabolic activity control of the L-lysine fermentation by restrained growth fed-batch strategies Biotechnology Progress. 7: 501-509. DOI: 10.1021/Bp00012A004 |
0.339 |
|
| 1991 |
Sambanis A, Lodish HF, Stephanopoulos G. A model of secretory protein trafficking in recombinant AtT-20 cells Biotechnology and Bioengineering. 38: 280-295. DOI: 10.1002/Bit.260380310 |
0.59 |
|
| 1990 |
Mavrovouniotis ML, Stephanopoulos G, Stephanopoulos G. Computer-Aided Synthesis Of Biochemical Pathways Biotechnology and Bioengineering. 36: 1119-1132. PMID 18595053 DOI: 10.1002/Bit.260361107 |
0.349 |
|
| 1990 |
Sambanis A, Stephanopoulos G, Lodish HF. Multiple episodes of induced secretion of human growth hormone from recombinant AtT-20 cells Cytotechnology. 4: 111-119. PMID 1367038 DOI: 10.1007/Bf00365091 |
0.588 |
|
| 1990 |
Hannoun BJM, Stephanopoulos G. Growth and fermentation model for alginate-entrapped Saccharomyces cerevisiae Biotechnology Progress. 6: 349-356. DOI: 10.1021/Bp00005A006 |
0.319 |
|
| 1990 |
Hannoun BJM, Stephanopoulos G. Intrinsic growth and fermentation rates of alginate-entrapped Saccharomyces cerevisiae Biotechnology Progress. 6: 341-348. DOI: 10.1021/Bp00005A005 |
0.328 |
|
| 1990 |
Sambanis A, Stephanopoulos G, Sinskey AJ, Lodish HF. Use of regulated secretion in protein production from animal cells: An evaluation with the AtT-20 model cell line Biotechnology and Bioengineering. 35: 771-780. DOI: 10.1002/Bit.260350804 |
0.591 |
|
| 1988 |
Stephanopoulos G, Lapudis GR. Chemostat dynamics of plasmid-bearing, plasmid-free mixed recombinant cultures Chemical Engineering Science. 43: 49-57. DOI: 10.1016/0009-2509(88)87125-2 |
0.308 |
|
| 1985 |
Stephanopoulos G, San K-, Davison BH. A novel bioreactor-cell precipitator combination for high-cell density, high-flow fermentations. Biotechnology Progress. 1: 250-259. PMID 20568173 DOI: 10.1002/Btpr.5420010409 |
0.312 |
|
| 1981 |
Stephanopoulos G, Fredrickson AG. Extinction probabilities in microbial predation: A birth and death approach Bulletin of Mathematical Biology. 43: 165-181. DOI: 10.1016/S0092-8240(81)90014-8 |
0.581 |
|
| 1979 |
Stephanopoulos G, Fredrickson AG. Coexistence of photosynthetic microorganisms with growth rates depending on the spectral quality of light Bulletin of Mathematical Biology. 41: 525-542. DOI: 10.1016/S0092-8240(79)80006-3 |
0.581 |
|
| 1979 |
STEPHANOPOULOS G, FREDRICKSON A. Coexistence of photosynthetic microorganisms with growth rates depending on the spectral quality of light Bulletin of Mathematical Biology. 41: 525-542. DOI: 10.1016/S0092-8240(79)80006-3 |
0.526 |
|
| 1979 |
Stephanopoulos G, Aris R, Fredrickson AG. A stochastic analysis of the growth of competing microbial populations in a continuous biochemical reactor Mathematical Biosciences. 45: 99-135. DOI: 10.1016/0025-5564(79)90098-1 |
0.659 |
|
| 1979 |
Stephanopoulos G, Fredrickson AG. Effect of spatial inhomogeneities on the coexistence of competing microbial populations Biotechnology and Bioengineering. 21: 1491-1498. DOI: 10.1002/Bit.260210817 |
0.553 |
|
| 1979 |
Stephanopoulos G, Frederickson AG, Aris R. The growth of competing microbial populations in a CSTR with periodically varying inputs Aiche Journal. 25: 863-872. DOI: 10.1002/Aic.690250515 |
0.5 |
|
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