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Nathaniel A. Hathaway, Ph.D. - Publications

Affiliations: 
2007 Harvard University, Cambridge, MA, United States 
Area:
Cell Biology, Biochemistry
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25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Yan X, Williams MR, Barboza Castillo AD, Kireev D, Hathaway NA. Relationship between lysine methyltransferase levels and heterochromatin gene repression in living cells and in silico. Pnas Nexus. 2: pgad062. PMID 37020498 DOI: 10.1093/pnasnexus/pgad062  0.307
2020 Skrajna A, Goldfarb D, Kedziora KM, Cousins EM, Grant GD, Spangler CJ, Barbour EH, Yan X, Hathaway NA, Brown NG, Cook JG, Major MB, McGinty RK. Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding. Nucleic Acids Research. PMID 32658293 DOI: 10.1093/Nar/Gkaa544  0.369
2020 Chiarella AM, Lu D, Hathaway NA. Epigenetic Control of a Local Chromatin Landscape. International Journal of Molecular Sciences. 21. PMID 32023873 DOI: 10.3390/Ijms21030943  0.354
2019 Gryder BE, Pomella S, Sayers C, Wu XS, Song Y, Chiarella AM, Bagchi S, Chou HC, Sinniah RS, Walton A, Wen X, Rota R, Hathaway NA, Zhao K, Chen J, et al. Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma. Nature Genetics. 51: 1714-1722. PMID 31784732 DOI: 10.1038/S41588-019-0534-4  0.337
2019 Chiarella AM, Butler KV, Gryder BE, Lu D, Wang TA, Yu X, Pomella S, Khan J, Jin J, Hathaway NA. Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Nature Biotechnology. PMID 31712774 DOI: 10.1038/S41587-019-0296-7  0.38
2019 Madigan VJ, Yuziuk JA, Chiarella AM, Tyson TO, Meganck RM, Elmore ZC, Tse LV, Hathaway NA, Asokan A. Ring finger protein 121 is a potent regulator of adeno-associated viral genome transcription. Plos Pathogens. 15: e1007988. PMID 31386698 DOI: 10.1371/Journal.Ppat.1007988  0.399
2019 Vignaux PA, Bregio C, Hathaway NA. Contribution of promoter DNA sequence to heterochromatin formation velocity and memory of gene repression in mouse embryo fibroblasts. Plos One. 14: e0217699. PMID 31269077 DOI: 10.1371/Journal.Pone.0217699  0.366
2019 Headley KM, Kedziora KM, Alejo A, Lai EZ, Purvis JE, Hathaway NA. Chemical screen for epigenetic barriers to single allele activation of Oct4. Stem Cell Research. 38: 101470. PMID 31170660 DOI: 10.1016/J.Scr.2019.101470  0.387
2019 MacDonald IA, Butler KV, Herring LE, Clinkscales SE, Yelagandula R, Stecher K, Bell O, Graves LM, Jin J, Hathaway NA. Pathway-Based High-Throughput Chemical Screen Identifies Compounds That Decouple Heterochromatin Transformations. Slas Discovery : Advancing Life Sciences R & D. 2472555219849838. PMID 31145866 DOI: 10.1177/2472555219849838  0.31
2019 Khodaverdian V, Tapadar S, MacDonald IA, Xu Y, Ho PY, Bridges A, Rajpurohit P, Sanghani BA, Fan Y, Thangaraju M, Hathaway NA, Oyelere AK. Deferiprone: Pan-selective Histone Lysine Demethylase Inhibition Activity and Structure Activity Relationship Study. Scientific Reports. 9: 4802. PMID 30886160 DOI: 10.1038/S41598-019-39214-1  0.372
2019 Chory EJ, Calarco JP, Hathaway NA, Bell O, Neel DS, Crabtree GR. Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome. Molecular Cell. 73: 61-72.e3. PMID 30472189 DOI: 10.1016/J.Molcel.2018.10.028  0.34
2018 Chiarella AM, Wang TA, Butler KV, Jin J, Hathaway NA. Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers. Journal of Visualized Experiments : Jove. PMID 30295665 DOI: 10.3791/58222  0.386
2018 Chiarella AM, Quimby AL, Mehrab-Mohseni M, Velasco B, Kasoji SK, Davis I, Dayton PA, Hathaway NA, Pattenden S. Cavitation enhancement increases the efficiency and consistency of chromatin fragmentation from fixed cells for downstream quantitative applications. Biochemistry. PMID 29658277 DOI: 10.1021/Acs.Biochem.8B00075  0.346
2017 Butler KV, Chiarella AM, Jin J, Hathaway NA. TARGETED GENE REPRESSION USING NOVEL BIFUNCTIONAL MOLECULES TO HARNESS ENDOGENOUS HISTONE DEACETYLATION ACTIVITY. Acs Synthetic Biology. PMID 29073761 DOI: 10.1021/Acssynbio.7B00295  0.421
2017 Butler KV, MacDonald IA, Hathaway NA, Jin J. Report And Application Of A Tool Compound Dataset. Journal of Chemical Information and Modeling. PMID 29035535 DOI: 10.1021/Acs.Jcim.7B00343  0.309
2017 Ren J, Hathaway NA, Crabtree GR, Muegge K. Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes. Epigenetics. 0. PMID 28621576 DOI: 10.1080/15592294.2017.1338234  0.377
2015 MacDonald IA, Hathaway NA. Epigenetic roots of immunologic disease and new methods for examining chromatin regulatory pathways. Immunology and Cell Biology. 93: 261-70. PMID 25533290 DOI: 10.1038/Icb.2014.105  0.325
2012 Hathaway NA, Bell O, Hodges C, Miller EL, Neel DS, Crabtree GR. Dynamics and memory of heterochromatin in living cells. Cell. 149: 1447-60. PMID 22704655 DOI: 10.1016/J.Cell.2012.03.052  0.354
2012 Dimova NV, Hathaway NA, Lee BH, Kirkpatrick DS, Berkowitz ML, Gygi SP, Finley D, King RW. APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1. Nature Cell Biology. 14: 168-76. PMID 22286100 DOI: 10.1038/Ncb2425  0.655
2010 Zeng X, Sigoillot F, Gaur S, Choi S, Pfaff KL, Oh DC, Hathaway N, Dimova N, Cuny GD, King RW. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 18: 382-95. PMID 20951947 DOI: 10.1016/J.Ccr.2010.08.010  0.609
2007 Kleijnen MF, Roelofs J, Park S, Hathaway NA, Glickman M, King RW, Finley D. Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites. Nature Structural & Molecular Biology. 14: 1180-8. PMID 18026118 DOI: 10.1038/Nsmb1335  0.604
2006 Crosas B, Hanna J, Kirkpatrick DS, Zhang DP, Tone Y, Hathaway NA, Buecker C, Leggett DS, Schmidt M, King RW, Gygi SP, Finley D. Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell. 127: 1401-13. PMID 17190603 DOI: 10.1016/J.Cell.2006.09.051  0.594
2006 Hanna J, Hathaway NA, Tone Y, Crosas B, Elsasser S, Kirkpatrick DS, Leggett DS, Gygi SP, King RW, Finley D. Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell. 127: 99-111. PMID 17018280 DOI: 10.1016/J.Cell.2006.07.038  0.607
2006 Kirkpatrick DS, Hathaway NA, Hanna J, Elsasser S, Rush J, Finley D, King RW, Gygi SP. Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nature Cell Biology. 8: 700-10. PMID 16799550 DOI: 10.1038/Ncb1436  0.642
2005 Hathaway NA, King RW. Dissecting cell biology with chemical scalpels. Current Opinion in Cell Biology. 17: 12-9. PMID 15661514 DOI: 10.1016/J.Ceb.2004.12.004  0.593
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