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Spencer A Freeman - Publications

Affiliations: 
The Hospital for Sick Children / University of Toronto, Toronto, Ontario, Canada 
Area:
Cell Biology
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Le T, Ferling I, Qiu L, Nabaile C, Assunção L, Roskelley CD, Grinstein S, Freeman SA. Redistribution of the glycocalyx exposes phagocytic determinants on apoptotic cells. Developmental Cell. PMID 38359833 DOI: 10.1016/j.devcel.2024.01.020  0.454
2024 Chadwick SR, Barreda D, Wu JZ, Ye G, Yusuf B, Ren D, Freeman SA. Two-pore channels regulate endomembrane tension to enable remodeling and resolution of phagolysosomes. Proceedings of the National Academy of Sciences of the United States of America. 121: e2309465121. PMID 38354262 DOI: 10.1073/pnas.2309465121  0.333
2023 Barreda D, Grinstein S, Freeman SA. Target lysis by cholesterol extraction is a rate limiting step in the resolution of phagolysosomes. European Journal of Cell Biology. 103: 151382. PMID 38171214 DOI: 10.1016/j.ejcb.2023.151382  0.494
2023 de Paz Linares GA, Freeman SA, Cai R. Using Ion Substitution and Fluid Indicators to Monitor Macropinosome Dynamics in Live Cells. Methods in Molecular Biology (Clifton, N.J.). 2692: 375-384. PMID 37365480 DOI: 10.1007/978-1-0716-3338-0_24  0.702
2023 Wu JZ, Zeziulia M, Kwon W, Jentsch TJ, Grinstein S, Freeman SA. ClC-7 drives intraphagosomal chloride accumulation to support hydrolase activity and phagosome resolution. The Journal of Cell Biology. 222. PMID 37010469 DOI: 10.1083/jcb.202208155  0.418
2023 Hirata Y, Cai R, Volchuk A, Steinberg BE, Saito Y, Matsuzawa A, Grinstein S, Freeman SA. Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis. Current Biology : Cb. PMID 36898371 DOI: 10.1016/j.cub.2023.02.060  0.715
2022 Freeman SA, Grinstein S, Orlowski J. Determinants, Maintenance and Function of Organellar pH. Physiological Reviews. PMID 35981302 DOI: 10.1152/physrev.00009.2022  0.419
2022 Yazdani S, Bilan PJ, Jaldin-Fincati JR, Pang J, Ceban F, Saran E, Brumell JH, Freeman SA, Klip A. Dynamic glucose uptake, storage and release by human microvascular endothelial cells. Molecular Biology of the Cell. mbcE22040146. PMID 35921166 DOI: 10.1091/mbc.E22-04-0146  0.485
2022 Mylvaganam S, Plumb J, Yusuf B, Li R, Lu CY, Robinson LA, Freeman SA, Grinstein S. The spectrin cytoskeleton integrates endothelial mechanoresponses. Nature Cell Biology. PMID 35817960 DOI: 10.1038/s41556-022-00953-5  0.445
2021 Freeman S, Grinstein S. Promoters and Antagonists of Phagocytosis: A Plastic and Tunable Response. Annual Review of Cell and Developmental Biology. PMID 34152790 DOI: 10.1146/annurev-cellbio-120219-055903  0.455
2021 Mylvaganam S, Freeman SA, Grinstein S. The cytoskeleton in phagocytosis and macropinocytosis. Current Biology : Cb. 31: R619-R632. PMID 34033794 DOI: 10.1016/j.cub.2021.01.036  0.529
2021 Chadwick SR, Grinstein S, Freeman SA. From the inside out: Ion fluxes at the centre of endocytic traffic. Current Opinion in Cell Biology. 71: 77-86. PMID 33706237 DOI: 10.1016/j.ceb.2021.02.006  0.473
2020 Imbert PRC, Saric A, Pedram K, Bertozzi CR, Grinstein S, Freeman SA. An Acquired and Endogenous Glycocalyx Forms a Bidirectional "Don't Eat" and "Don't Eat Me" Barrier to Phagocytosis. Current Biology : Cb. PMID 33096038 DOI: 10.1016/j.cub.2020.09.082  0.44
2020 Westman J, Freeman SA, Grinstein S. Unconventional role of lysosomes in phagocytosis. Cell Calcium. 91: 102269. PMID 32818767 DOI: 10.1016/J.Ceca.2020.102269  0.421
2020 Mylvaganam S, Riedl M, Vega A, Collins RF, Jaqaman K, Grinstein S, Freeman SA. Stabilization of Endothelial Receptor Arrays by a Polarized Spectrin Cytoskeleton Facilitates Rolling and Adhesion of Leukocytes. Cell Reports. 31: 107798. PMID 32579925 DOI: 10.1016/J.Celrep.2020.107798  0.432
2020 Freeman SA, Grinstein S. Phagocytosis: Mechanosensing, Traction Forces, and a Molecular Clutch. Current Biology : Cb. 30: R24-R26. PMID 31910372 DOI: 10.1016/J.Cub.2019.11.047  0.459
2019 Freeman SA, Uderhardt S, Saric A, Collins RF, Buckley CM, Mylvaganam S, Boroumand P, Plumb J, Germain RN, Ren D, Grinstein S. Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance. Science (New York, N.Y.). PMID 31806695 DOI: 10.1126/Science.Aaw9544  0.518
2019 Ostrowski PP, Freeman SA, Fairn G, Grinstein S. Dynamic Podosome-Like Structures in Nascent Phagosomes Are Coordinated by Phosphoinositides. Developmental Cell. PMID 31231039 DOI: 10.1016/J.Devcel.2019.05.028  0.656
2019 Marques PE, Nyegaard S, Collins RF, Troise F, Freeman SA, Trimble WS, Grinstein S. Multimerization and Retention of the Scavenger Receptor SR-B1 in the Plasma Membrane. Developmental Cell. PMID 31231038 DOI: 10.1016/J.Devcel.2019.05.026  0.471
2018 Mylvaganam SM, Grinstein S, Freeman SA. Picket-fences in the plasma membrane: functions in immune cells and phagocytosis. Seminars in Immunopathology. PMID 30209546 DOI: 10.1007/S00281-018-0705-X  0.516
2018 Freeman SA, Grinstein S. Resolution of macropinosomes, phagosomes, and autolysosomes: osmotically-driven shrinkage enables tubulation and vesiculation. Traffic (Copenhagen, Denmark). PMID 30159984 DOI: 10.1111/Tra.12614  0.497
2018 Schlam D, Grinstein S, Freeman SA. Screening for Rho GTPase Modulators in Actin-Dependent Processes Exemplified by Phagocytosis. Methods in Molecular Biology (Clifton, N.J.). 1821: 107-127. PMID 30062408 DOI: 10.1007/978-1-4939-8612-5_8  0.441
2018 Vega AR, Freeman SA, Grinstein S, Jaqaman K. Multistep Track Segmentation and Motion Classification for Transient Mobility Analysis. Biophysical Journal. 114: 1018-1025. PMID 29539390 DOI: 10.1016/J.Bpj.2018.01.012  0.359
2018 Freeman SA, Vega A, Riedl M, Collins RF, Ostrowski PP, Woods EC, Bertozzi CR, Tammi MI, Lidke DS, Johnson P, Mayor S, Jaqaman K, Grinstein S. Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement. Cell. 172: 305-317.e10. PMID 29328918 DOI: 10.1016/J.Cell.2017.12.023  0.455
2018 Grinstein S, Freeman SA. Receptor Mobility is Regulated by the Cytoskeleton Connected to an Exoskeleton via Transmembrane Pickets: Role in Phagocytosis Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.081  0.432
2017 Sharfe N, Karanxha A, Dadi H, Merico D, Chitayat D, Herbrick JA, Freeman S, Grinstein S, Roifman CM. Dual loss of p110δ PI3-kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features. The Journal of Allergy and Clinical Immunology. PMID 29180244 DOI: 10.1016/J.Jaci.2017.10.033  0.334
2017 Marques PE, Grinstein S, Freeman SA. SnapShot:Macropinocytosis. Cell. 169: 766-766.e1. PMID 28475901 DOI: 10.1016/j.cell.2017.04.031  0.4
2017 Hua R, Cheng D, Coyaud É, Freeman S, Di Pietro E, Wang Y, Vissa A, Yip CM, Fairn GD, Braverman N, Brumell JH, Trimble WS, Raught B, Kim PK. VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis. The Journal of Cell Biology. PMID 28108526 DOI: 10.1083/Jcb.201608128  0.674
2016 Saric A, Grinstein S, Freeman SA. Measurement of Autolysosomal pH by Dual-Wavelength Ratio Imaging. Methods in Enzymology. 588: 15-29. PMID 28237098 DOI: 10.1016/bs.mie.2016.09.073  0.383
2016 Freeman SA, Grinstein S. Phagocytosis: How Macrophages Tune Their Non-professional Counterparts. Current Biology : Cb. 26: R1279-R1282. PMID 27997839 DOI: 10.1016/J.Cub.2016.10.059  0.403
2016 Ostrowski PP, Grinstein S, Freeman SA. Diffusion Barriers, Mechanical Forces, and the Biophysics of Phagocytosis. Developmental Cell. 38: 135-46. PMID 27459066 DOI: 10.1016/J.Devcel.2016.06.023  0.529
2016 Schlam D, Canton J, Carreño M, Kopinski H, Freeman SA, Grinstein S, Fairn GD. Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis. Mbio. 7. PMID 27048806 DOI: 10.1128/Mbio.02242-15  0.677
2016 Wong HS, Jaumouillé V, Freeman SA, Doodnauth SA, Schlam D, Canton J, Mukovozov IM, Saric A, Grinstein S, Robinson LA. Chemokine Signaling Enhances CD36 Responsiveness toward Oxidized Low-Density Lipoproteins and Accelerates Foam Cell Formation. Cell Reports. PMID 26997267 DOI: 10.1016/j.celrep.2016.02.071  0.453
2016 Freeman SA, Goyette J, Furuya W, Woods EC, Bertozzi CR, Bergmeier W, Hinz B, van der Merwe PA, Das R, Grinstein S. Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis. Cell. 164: 128-140. PMID 26771488 DOI: 10.1016/J.Cell.2015.11.048  0.437
2015 Schlam D, Bagshaw RD, Freeman SA, Collins RF, Pawson T, Fairn GD, Grinstein S. Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins. Nature Communications. 6: 8623. PMID 26465210 DOI: 10.1038/Ncomms9623  0.638
2015 Freeman SA, Jaumouillé V, Choi K, Hsu BE, Wong HS, Abraham L, Graves ML, Coombs D, Roskelley CD, Das R, Grinstein S, Gold MR. Erratum: Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor. Nature Communications. 6: 7015. PMID 25881569 DOI: 10.1038/ncomms8015  0.422
2015 Freeman SA, Jaumouillé V, Choi K, Hsu BE, Wong HS, Abraham L, Graves ML, Coombs D, Roskelley CD, Das R, Grinstein S, Gold MR. Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor. Nature Communications. 6: 6168. PMID 25644899 DOI: 10.1038/Ncomms7168  0.48
2014 Freeman SA, Grinstein S. Phagocytosis: receptors, signal integration, and the cytoskeleton. Immunological Reviews. 262: 193-215. PMID 25319336 DOI: 10.1111/imr.12212  0.49
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