Area:
Drosophila Cell cycle & Growth
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High-probability grants
According to our matching algorithm, Laura Buttitta is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2015 — 2016 |
Buttitta, Laura A |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Cell Cycle Re-Entry in the Aging Adult Brain
? DESCRIPTION (provided by applicant): Aging-associated cognitive decline has serious public health and economic consequences, which will increase as the percentage of aged Americans rises. Thus far there is little effective treatment to combat this problem, in part because the underlying causes remain unclear. The aged mammalian brain exhibits evidence of cell cycle de-regulation and aberrant cell cycle re-entry of postmitotic cells in the brain has been proposed to be both a cause and a consequence of neurodegeneration. Most of the research on cell cycle re-entry in the aging brain has been limited to correlative studies due to difficulty in obtaining aged samples, inconsistencies in measuring cell cycle re-entry and difficulty in manipulating cell cycle regulators specifically in the brain during aging in mammalian model systems. We have observed that the brain of the fruit fly Drosophila melanogaster exhibits evidence of age-associated cell cycle re-entry and this project seeks to establish Drosophila as a genetically tractable and quickly aging model system to study and manipulate cell cycle re-entry in the aging brain. In Aim 1, we establish when and where cell cycle re-entry occurs in the aged fly brain, under normal physiological aging conditions. In Aim 2, we determine the biological outcomes of manipulating cell cycle re-entry in the brain on aging phenotypes. Successful completion of the proposed work will establish a new genetically tractable model system to study the relationship of aging and cell cycle re-entry in the brain and resolve the cause-effect relationship of cell cycle re-entry in the brain and behavioral decline with age. This research may indicate new avenues to treat aging related neural decline by targeting cell cycle machinery. Longer-term future directions for this research will include filling in the molecular details that link aging and cell cycle de-regulation in the brain.
|
0.958 |
2018 — 2020 |
Buttitta, Laura A |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Chromatin Remodeling At Cell Cycle Exit @ University of Michigan At Ann Arbor
Project Summary/Abstract Cell proliferation must be precisely controlled during development to produce tissues of the correct shape, composition and size. Terminal differentiation is often associated with exit from the cell cycle and coupled with a switch to a permanently postmitotic state. This is an important developmental process, as permanent exit from the cell cycle is likely to represent the most common cellular state in adult animals. Our data indicates a critical role for specific nucleosome remodelers in proper initiation and maintenance of cell cycle exit. This is consistent with our finding that accessibility at many gene regulatory elements also changes during cell cycle exit. The goal of our proposed research is to understand how cell cycle gene expression is shut down at the right places and times during development to establish and maintain a stable postmitotic state in differentiating tissues. To accomplish this, we propose three aims: 1. To define the specific gene expression and regulatory element accessibility changes that are due to cell cycle exit and how they are altered upon forced cell cycle re-entry 2. To determine how developmental signals coordinate cell cycle exit with differentiation events and 3. To understand the role of specific nucleosome remodelers in promoting cell cycle exit.
|
0.958 |