2021 |
Brown, Gregory K [⬀] |
P50Activity Code Description: To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These grants differ from program project grants in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes. |
Administrative Core @ University of Pennsylvania
The Administrative (Admin) Core of the Penn INSPIRE Center will lead senior and emerging investigators in establishing, implementing, and evaluating a cutting-edge, interdisciplinary scientific agenda that leverages implementation science to optimize suicide prevention for underserved populations. Based at the Penn Perelman School of Medicine, INSPIRE will have interdisciplinary collaborations from the Penn Center for Clinical Epidemiology and Biostatistics, Children?s Hospital of Philadelphia, and the Penn School of Nursing. INSPIRE will integrate perspectives from psychology, implementation science, psychiatry, machine learning, health economics, and health information technology. Realizing the benefit of such a rich, interdisciplinary research endeavor requires strong and creative centralized leadership as well as efficient and effective coordination of services, logistics, and resources. Led by Center Co-Directors G. Brown and Oquendo, the Admin Core will be INSPIRE?s organizational, governance, and strategic-planning hub and will address three Aims. First, the Core will provide scientific and programmatic leadership to maximize integration, rigor, and synergy across Center components, investigators, and external affiliates. It will institute and coordinate an internal Center Steering Committee and Stakeholder Committee and an External Advisory Committee for transparency and input on governance, planning, and evaluation. Centralized administrative, fiscal, and organizational coordination of INSPIRE Cores and Research Projects will be effected by an experienced, efficient Administrative Support Team. Second, the Admin Core will ensure scientific innovation and responsiveness to evolving research, practice, and policy needs through the INSPIRE Pilot Studies Program that will support 10 pilot studies over the course of the Center. The Core also will establish the INSPIRE Suicide Prevention Scholars Program to engage and build capacity of both early-stage and established investigators who can make novel interdisciplinary contributions to the suicide prevention research evidence base. Third, the Admin Core will amplify the impact of our research and make INSPIRE resources available across scientific, practice, and policy communities through a dynamic INSPIRE website as well as other targeted mechanisms for wide, multi-sector dissemination of Center findings, research tools, and other products. Thus, through the Admin Core, INSPIRE Leadership will maximize generation of high-impact knowledge about suicide prevention strategies designed to be rapidly deployable in a wide range of settings serving the most vulnerable, and often disenfranchised, populations. The Core?s management strategy will emphasize shared leadership, investigator support and mentoring, and intensive engagement of stakeholders at every level (planning, evaluation, research, and dissemination) to maximize impact.
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0.964 |
2021 |
Brown, Gregory K [⬀] |
P50Activity Code Description: To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These grants differ from program project grants in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes. |
Signature Project @ University of Pennsylvania
The Signature Project of the Penn Innovation in Suicide Prevention Implementation Research (INSPIRE) Center is a large-scale research study designed to examine the effectiveness and implementation of an evidence-based intervention to lower suicide risk in health care settings. The Project will leverage the methodological and administrative support of the INSPIRE Center with its focus on optimizing implementation of practice-based suicide prevention interventions for minority and disadvantaged populations. Individuals at high risk for suicide often present to acute care settings, such as emergency departments (EDs), and then typically are hospitalized or referred for outpatient mental health treatment. Yet, despite being at increased risk of suicidal behavior and suicide following an ED visit, many patients do not attend outpatient treatment. Brief evidenced-based interventions such as the Safety Planning Intervention and follow-up services (SPI+) are available to mitigate this risk and engage patients in outpatient treatment. However, such practices often can be challenging for busy ED clinicians to provide for suicidal patients. Our interdisciplinary team of suicide, implementation, health services, qualitative and quantitative researchers as well as diverse stakeholder groups of ED clinicians, health systems leaders, mental health clinicians, and patients will collaborate to improve the delivery of ED-based suicide prevention efforts. We propose a novel delivery model in which ED staff will connect patients at risk for suicide to mental health clinicians who are located external to the ED. These off-site licensed and credentialed clinicians will provide SPI+ via telehealth for ED patients prior to discharge and provide follow-up services after ED discharge as part of an innovative Suicide Prevention Consultation Center (SPCC). The Project has three Specific Aims. Aim 1 will use a stepped-wedge cluster-randomized design to evaluate the effectiveness of SPI+ delivered by SPCC clinicians via telehealth compared to SPI+ delivered by SPI+-trained ED clinicians on rates of suicidal behavior and engagement in care following ED discharge. Aim 2 will evaluate the implementation of SPI+ delivered by SPCC clinicians compared to SPI+ delivered by ED clinicians on key implementation outcomes including adoption, fidelity, acceptability, and feasibility and will also explore the mediation of clinician intentions, norms, and self-efficacy on the fidelity of SPI+. Aim 3 will evaluate the costs to ED and SPCC practices and examine potential cost offsets to the health system to provide evidence of SPCC scalability and sustainability. If successful and cost effective, use of a SPCC, external to EDs, could become a scalable model for providing suicide prevention evidenced-based practices to those at risk for suicide presenting for emergency care with the potential to save lives.
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0.964 |