Stephen H. Safe

Affiliations:	1973-1981		University of Guelph, Guelph, Ontario, Canada
	1981-		Texas A & M University, College Station, TX, United States

Area:

Molecular Biology, Biochemistry

Parents

Ewart Ray Herbert Jones	grad student	1965	Oxford
(Plant acetylenes)
Viktor N Thaller	grad student	1965	Oxford

Children

Andrew Parkinson	grad student	1981	University of Guelph
James P. Landers	grad student	1990	University of Guelph
Timothy R. Zacharewski	grad student	1990	Texas A & M (Cell Biology Tree)
Andrew J. McDougal	grad student	2000	Texas A & M
Gulan Sun	grad student	2000	Texas A & M
Emely Castro Rivera	grad student	2001	Texas A & M
Chunhua Qin	grad student	2001	Texas A & M
Carrie A. Vyhlidal	grad student	2001	Texas A & M
Wen Xie	grad student	2001	Texas A & M
Ismael J. Samudio	grad student	2002	Texas A & M
Bradley M. Saville	grad student	2002	Texas A & M
Matthew A. Stoner	grad student	2002	Texas A & M
Mark T. Wormke	grad student	2002	Texas A & M
Kyounghyun Kim	grad student	2004	Texas A & M
Ma'en A. Rahim	grad student	2004	Texas A & M
Kelcey M. Walker	grad student	2004	Texas A & M
Shaheen M. Khan	grad student	2005	Texas A & M
Sharon K. Ngwenya	grad student	2005	Texas A & M
Charles R. Partridge	grad student	2005	Texas A & M
Maya M. Scott	grad student	2005	Texas A & M
Qian Wu	grad student	2005	Texas A & M
Chien-Cheng Chen	grad student	2006	Texas A & M
Sudhakar R. Chintharlapalli	grad student	2006	Texas A & M
Kelly J. Higgins	grad student	2006	Texas A & M
Leela Kotha	grad student	2006	Texas A & M
Wan-Ru Lee	grad student	2006	Texas A & M
Kathryn E. Vanderlaag	grad student	2007	Texas A & M
Sabitha Papineni	grad student	2008	Texas A & M
Indira D. Jutooru	grad student	2010	Texas A & M
Satya S. Pathi	grad student	2012	Texas A & M
Larry W. Robertson	post-doc		Texas A & M (PHTree)

Collaborators

BETA: Related publications

Publications

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Zhang L, Gatlin V, Gupta S, et al. (2025) Expression of Prooncogenic Nuclear Receptor 4A (NR4A)-Regulated Genes β1-Integrin and G9a Inhibited by Dual NR4A1/2 Ligands. International Journal of Molecular Sciences. 26
Safe S, Oany AR, Upadhyay S, et al. (2025) Orphan Nuclear Receptor 4A1 (NR4A1) and NR4A2are Endogenous Regulators of CD71 and TheirLigands Induce Ferroptosis in Breast Cancer. Research Square
Hailemariam A, Upadhyay S, Srivastava V, et al. (2025) Perfluorooctane Sulfonate (PFOS) and Related Compounds Induce Nuclear Receptor 4A1 (NR4A1)-Dependent Carcinogenesis. Chemical Research in Toxicology
Safe S, Farkas E, Hailemariam AE, et al. (2025) Activation of Genes by Nuclear Receptor/Specificity Protein (Sp) Interactions in Cancer. Cancers. 17
Upadhyay S, Lee M, Zhang L, et al. (2024) Dual nuclear receptor 4A1 (NR4A1/NR4A2) ligands inhibit glioblastoma growth and target TWIST1. Molecular Pharmacology. 107: 100009
Johnson S, Yu Z, Li X, et al. (2024) A novel NR4A2-HuR axis promotes pancreatic cancer growth and tumorigenesis that is inhibited by NR4A2 antagonists. American Journal of Cancer Research. 14: 4337-4352
Zhang L, Martin G, Mohankumar K, et al. (2023) Piperlongumine is a ligand for the orphan nuclear receptor 4A1 (NR4A1). Frontiers in Pharmacology. 14: 1223153
Zhang L, Mohankumar K, Martin G, et al. (2023) Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice. Endocrinology
Safe S, Zhang L. (2022) The Role of the Aryl Hydrocarbon Receptor (AhR) and Its Ligands in Breast Cancer. Cancers. 14
Schoeller A, Karki K, Jayaraman A, et al. (2022) Short chain fatty acids exhibit selective estrogen receptor downregulator (SERD) activity in breast cancer. American Journal of Cancer Research. 12: 3422-3436

Stephen H. Safe

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