Christopher R. Gault, Ph.D.
Affiliations: | 2012 | Medical University of South Carolina, Charleston, SC, United States |
Area:
Molecular Biology, Cell Biology, OncologyGoogle:
"Christopher Gault"Parents
Sign in to add mentor| Lina M. Obeid | grad student | 2012 | MUSC | |
| (Ras regulates bioactive sphingolipids in a sphingosine kinase 1 dependent manner to affect oncogenesis.) | ||||
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| Trayssac M, Clarke CJ, Stith JL, et al. (2021) Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides. Cell Death & Disease. 12: 27 |
| Gault CR, Eblen ST, Neumann CA, et al. (2012) Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner. The Journal of Biological Chemistry. 287: 31794-803 |
| Gault CR, Obeid LM. (2011) Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy. Critical Reviews in Biochemistry and Molecular Biology. 46: 342-51 |
| Salas A, Ponnusamy S, Senkal CE, et al. (2011) Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood. 117: 5941-52 |
| Jenkins RW, Clarke CJ, Canals D, et al. (2011) Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. The Journal of Biological Chemistry. 286: 13292-303 |
| Gault CR, Obeid LM, Hannun YA. (2010) An overview of sphingolipid metabolism: from synthesis to breakdown. Advances in Experimental Medicine and Biology. 688: 1-23 |
| Anelli V, Gault CR, Snider AJ, et al. (2010) Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2727-38 |
| Mahdy AE, Cheng JC, Li J, et al. (2009) Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 430-8 |
| Anelli V, Gault CR, Cheng AB, et al. (2008) Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2. The Journal of Biological Chemistry. 283: 3365-75 |