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Alexander Varshavsky

Affiliations: 
Biology and Biological Engineering California Institute of Technology, Pasadena, CA 
Area:
Protein degradation, ubiquitin
Website:
http://www.bbe.caltech.edu/content/alexander-j-varshavsky
Google:
"Alexander Varshavsky"
Bio:

http://www.nasonline.org/member-directory/members/67746.html

Mean distance: 18.4 (cluster 18)
 
Cross-listing: Cell Biology Tree - Chemistry Tree

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Parents

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Children

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Daniel Finley grad student Caltech (Cell Biology Tree)
Mark Solomon grad student 1986 MIT (Cell Biology Tree)
Bonnie Bartel grad student 1990 MIT (Chemistry Tree)
Anna Shemorry grad student 2013 Caltech
Brandon Wadas grad student 2008-2016 Caltech (Cell Biology Tree)
Michael Ellison post-doc MIT (Cell Biology Tree)
Stefan Jentsch post-doc MIT
Mark W. Hochstrasser post-doc 1990 MIT (Chemistry Tree)
Jixi Li post-doc 2006-2008 Caltech (Chemistry Tree)

Collaborators

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Hyun Kyu Song collaborator Caltech (Chemistry Tree)
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Publications

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Kim BH, Kim MK, Oh SJ, et al. (2022) Crystal structure of the Ate1 arginyl-tRNA-protein transferase and arginylation of N-degron substrates. Proceedings of the National Academy of Sciences of the United States of America. 119: e2209597119
Chen SJ, Kim L, Song HK, et al. (2021) Aminopeptidases trim Xaa-Pro proteins, initiating their degradation by the Pro/N-degron pathway. Proceedings of the National Academy of Sciences of the United States of America. 118
Vu TTM, Mitchell DC, Gygi SP, et al. (2020) The Arg/N-degron pathway targets transcription factors and regulates specific genes. Proceedings of the National Academy of Sciences of the United States of America
Vu TTM, Varshavsky A. (2020) The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway. Biochemistry
Dong C, Chen SJ, Melnykov A, et al. (2020) Recognition of nonproline N-terminal residues by the Pro/N-degron pathway. Proceedings of the National Academy of Sciences of the United States of America
Oh JH, Hyun JY, Chen SJ, et al. (2020) Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling. Proceedings of the National Academy of Sciences of the United States of America
Chen SJ, Melnykov A, Varshavsky A. (2020) Evolution of Substrates and Components of the Pro/N-Degron Pathway. Biochemistry
Melnykov A, Chen SJ, Varshavsky A. (2019) Gid10 as an alternative N-recognin of the Pro/N-degron pathway. Proceedings of the National Academy of Sciences of the United States of America
Varshavsky A. (2019) On the cause of sleep: Protein fragments, the concept of sentinels, and links to epilepsy. Proceedings of the National Academy of Sciences of the United States of America
Varshavsky A. (2019) N-degron and C-degron pathways of protein degradation. Proceedings of the National Academy of Sciences of the United States of America. 116: 358-366
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